Digital Commons Network^™

The Role Of A-Layer In Polyunsaturated Fatty Acid (Pufa)-Mediated Effects On Aeromonas Salmonicida Subsp. Salmonicida, Allen Lin

Honors Theses

Aeromonas salmonicida subsp. salmonicida is a Gram-negative bacterium that infects salmonids and non-salmonids worldwide leading to an infection known as furunculosis, which is characterized by skin lesions and hemorrhages of the fish epidermis. This infection is carried out by a A+ (virulent strain) of A. salmonicida containing an important virulent factor known as the A-layer, which is a 2D paracrystalline structure that binds to the basement membrane and functions to promote adherence to host membranes and resistance to host defense. The purpose of this study was to examine the ability of the A+ A. salmonicida to incorporate exogenous fatty acids …

The Indirect Effect Of Childhood Trauma On Body Mass Index Through Exercise Frequency, Andreana Durham

Honors Theses

Objective: Research pertaining to Body Mass Index (BMI) and Childhood Trauma (CT) is very limited, with the main focus being on how these two variables correlate, disregarding other possible covariates. The purpose of the current study was to examine the effects of CT on BMI while including Exercise Frequency as a mediator of this relationship and sex as a moderator for both the direct and indirect relationships among these variables. Methods: Participants included 1,812 individuals (57.9% female and 42.1% male) who completed the Behavior Health Questionnaire, which included questions looking at exercise frequency, CT, and BMI. Results: CT was related …

Biofortification As A Sustainable Solution For 'Hidden Hunger': Evaluating Its Impact On The Environment, Nutrition, Culture, And Ethics, Elysia Lewis

Honors Theses

Micronutrient malnutrition, also referred to as ‘hidden hunger’, negatively impacts the health of millions of people around the world. Because of this, several strategies to reduce malnutrition have been proposed, one of which is biofortification. The process of biofortification increases the nutrient content of plants during their vegetative life cycle. Research has been conducted that shows the ability of biofortification to increase micronutrient content in crops, so the next step is successful implementation and adoption by consumers. This paper reviews several publications that look at biofortification with respect to the environment, sustainability, human nutrition, culture, and ethics from a variety …

Techniques For The Enantioselective Asymmetric Synthesis Of Benzyl Substituted Malonic Acid Esters, Madison Hansen

Honors Theses

A popular method for the enantioselective synthesis of substituted malonic half esters is hydrolysis via Pig Liver Esterase (PLE), however some substrates produce low enantiomeric excess, namely benzyl-substituted malonic esters. Presented here are alternative methods explored for this synthesis, the first being phase-transfer catalyzed hydrolysis via N-benzyl quaternary ammonium salts derived from cinchona alkaloids. The second method utilized chiral auxiliary directed benzylation with auxiliaries including menthol and oxazolidinones. Though unsuccessful, this research provided valuable groundwork in the investigation for the enantioselective asymmetric synthesis of benzyl-substituted malonic acid esters.

Keywords: Pig Liver Esterase, Enantioselectivity, Phase-Transfer Catalysis, Cinchona Alkaloids, Quaternary Ammonium …

The Relationship Between Status Motives And Social Activism, Olajuwon Olagbegi

Honors Theses

Numerous social and cultural events have resulted in increased interest and participation in social activism in the United States, stemming from mounting dissatisfaction with social inequality. Though explanations have previously included increased issue exposure and awareness due to the proliferation of digital media and increases in progressive ideology amongst the nation’s younger generation, the current study tests the hypothesis that social activism may in part be motivated by interest in status acquisition, given the evolutionary value of status for securing access to resources and mates. To test this hypothesis, participants were randomly assigned to a status versus control priming condition …

Investigation Of N-Sulfonyliminium Ion Triggered Cyclizations For The Synthesis Of Piperidine Scaffolds, Kaitlyn Birkhoff

Honors Theses

In consideration of the on-going global pandemic, immediate access to Food and Drug Administration approved pharmaceutical medications and vaccines is a matter of utmost priority to our national healthcare system. One significant modality in managed care is the dispensation of prescription drugs for the prevention or treatment of illnesses and diseases. According to the Centers for Disease Control and Prevention, physicians order and provide over 2.9 billion prescriptions each year with analgesics, antihyperlipidemics, and dermatological agents being the most prescribed therapeutic classes. Within those classes exists a disparate variety of chemical structures that must be prepared on a metric ton …

Comparative Genome Analysis Of Fungal Antagonists Marinomonas Ostreistagni 398 And M. Spartinae 468., Jessie L. Fields

Honors Theses

Under certain conditions, the Spartina alterniflora and Juncus roemerianus grasses in marshes undergo progressive decline in an event known as Saltwater Marsh Dieback, which may be attributed to the presence of the plant pathogenic fungi Fusarium. The microbiomes of S. alterniflora and J. roemerianus from Deer Island, MS were characterized and Fusarium suppressing bacteria were identified. Among isolates capable of antagonizing Fusarium were Marinomonas ostreistagni 398 and M. spartinae 468. Despite the progress in understanding the diversity of Marinomonas, our ability to explain ecological, metabolic, and biochemical traits of marinomonads at the genomic sequence level remains limited. Analysis …

Test Transferability Of 3d-Mot Training On Soccer Specific Parameters, Micaela Dusseault

Honors Theses

Objective: The benefits of perceptual-cognitive training in elite level athletes has recently been investigated in multiple sports such as basketball, soccer, and archery, but conclusive evidence proving test transferability of 3D-MOT training is lacking. The purpose of this research is to examine the transferability of perceptual-cognitive training to on-field soccer performance parameters. Participants: NCAA Division I women’s soccer players (n=22) between the ages of 18-25 who were placed into either the experimental group (n=10) or control group (n=12). After baseline testing for both groups to determine visual tracking speed (VTS), the experimental group completed 10 3D-MOT training sessions with NeuroTracker …

A Case For The Decriminalization Of Simple Possession Of Narcotics In Mississippi, Stroud Tolleson

Honors Theses

Through its incarceration of simple possession offenders, Mississippi is failing to acknowledge the severity of addiction and importance of mental health. In this paper, I will examine Mississippi’s history of opinion and policy on drug use. In order to gain a better understanding of addiction and Mississippi’s criminal justice system, I interview several individuals with experience in varying aspects of these issues. Mississippi has one of the highest rates of incarceration in the United States, with stringent laws regarding the possession of narcotics. Mississippi’s mental health resources have been deemed unconstitutionally deficient on more than one occasion, and addicts are …

Strategies For Socioeconomic Development: A Study Of Nonprofit Practices, Alexis L. Dahl Walls

Honors Theses

This project seeks to examine methods in which nonprofit organizations (NPOs) are able to further their impact, specifically in regard to the socioeconomic development of their communities. This is done through examining consequences of socioeconomic disparities such as health disparities and increased crime rates, reviewing a number of commonly used NPO strategies, and emphasizing the importance of performance measurement tactics. All information was gathered through the combination of a complete literature review and a case study on a local nonprofit organization: MadisonHome Inc. It is important for nonprofit organizations to implement a variety of measurement tactics in order to determine …

Pollinator Gardens And Their Significance, Emma Lee

Honors Theses

Abstract description: Pollinator populations are declining, leading to a global issue. This is due to human interference through intense agricultural production, habitat fragmentation, and pesticide use. Pollinators, mostly insects, are important for the reproductive success of plants and also provide many other benefits to humans like helping produce the foods we commonly eat. To be able to survive, pollinators need to have proper shelter and nectar. One way to supplement these needs for pollinators is creating pollinator gardens. Pollinator gardens should include a mix of trees, shrubs, and flowers that have large nectar rewards and are species that are preferred …

The Puerto Rican Diaspora: Evaluating Constructions Of Race And Ethnicity, Megan E. Walter

Honors Theses

The Spanish first colonized Puerto Rico in the 16^th century. The implementation of slavery shaped cultural traditions, agricultural practices, and established a socio-racial hierarchy. When Puerto Rico was acquired by the United States, legal and economic changes intensified race relations and classism. These global powers established notions of race and ethnicity which continue to dominate diasporic and identity discourse. Nearly a century later, the lasting effects of imperialism have converged with two decades of recurrent calamities, resulting in mass migration off the island and growing Puerto Rican communities within the U.S., notably in New York and Florida. By tracing …

Factors That Influence The Choice To Major In Stem For Latino And Non-Latino Students And Professionals, Ivan Olivas

Honors Theses

Latinos are the largest minority group in the United States, with 18.5 percent of the nation’s population. However, when it comes to Latinos in STEM, they represent only 8 percent of all STEM workers. This disparity can be largely traced to disproportionally low numbers in graduation rates in high school and college, in conjunction with the lack of exposure to STEM fields and access to rigorous K-12 curriculums associated with STEM pathways. The survey incorporated into this research investigates which factors influence Latinos in choosing a STEM major. The survey questions focused on high school academics, parental educational attainment, home …

Shy Or Anxious? Examining The Efficacy Of School-Based Interventions For Childhood Social Anxiety, Samantha Neuhaus

Honors Theses

Social anxiety disorder and shyness share many overlapping features, leading to debate over where they become distinctive from each other. The theory of a shyness and social anxiety continuum has been suggested, depicting shyness on one end and social anxiety disorder as the more severe and maladaptive opposite end. Considering additional factors such as comorbidity and cultural differences, school based interventions can be implemented as a preventative and treatment measure for social anxiety across the continuum. Multiple intervention methods are utilized across school based interventions, and of eleven interventions specifically analyzed, it was found that the interventions are most often …

Peeling Off The Proof: Using Peel-Away Polymer Technology In The Collection Of Ignitable Liquids During Arson Investigations, Cassidy Laney

Honors Theses

Determining the presence of ignitable liquids at the scene of a fire is a key part of any arson investigation. Residues of ignitable liquids are most often found in absorbent or porous material as there is a chance that some liquid will remain in the pores of the substrate after a fire. Unfortunately, the collection of ignitable liquids from porous surfaces such as concrete is especially difficult given the fixed nature of the substrate. Several on-site collection techniques have been developed to collect the ignitable liquid from the concrete directly at the scene, however they each have their own drawbacks …

The Influence Of Bottom Type And Water Column Stratification On Reef Fish Community Structure At Gray’S Reef National Marine Sanctuary, Bridget Campbell

Honors Theses

Understanding the physical and oceanographic differences across reef habitats can help researchers assess how those differences influence fish distribution and community structure, which leads to a better understanding of what a healthy reef system looks like. The traditional methods used to assess fish communities on temperate reefs are limited and often focus solely on either the reef structure or water column conditions alone. An assessment of both data sets yields a more complete understanding of the ecosystem as a whole. In this study, Gray’s Reef National Marine Sanctuary (GRNMS) was surveyed both inside and outside a Marine Protected Area (MPA) …

Microglia Polarize In Response To Transactive Response Dna-Binding Protein-43 (Tdp-43) And Display Partial Recovery After Removal Of The Stimulus, Alicen Wilcox

Honors Theses

The proper response to protein signals is necessary for a healthy central nervous system (CNS), and protein dysregulation is a feature of neurodegenerative diseases. Transactive response DNA-binding protein-43 (TDP-43) is an intranuclear protein, but mislocalization is associated with amyotrophic lateral sclerosis (ALS). TDP-43 is released into the extracellular space where it is sensed by microglia, the CNS-resident immune cells. Our data and the literature suggest that microglia respond to TDP-43 dysregulation by increasing CNS inflammation. The goal of this study was to determine the impact of TDP-43 on microglial function and the extent to which microglia recovery. To study the …

Lost In Time And Lost In Space: Chronotopes In Thomas Pynchon’S Against The Day, Stephen Margavio

Honors Theses

In his 1937 essay “Forms of Time and of the Chronotope in the Novel,” Russian literary theorist Mikhail Bakhtin coins the term “chronotope” to discuss the inherently interconnected nature of time and space in narrative constructions. According to Bakhtin, there are a number of specific chronotopes (or space/time configurations) that help to define literary genres. Applying Bakhtin’s concepts to Thomas Pynchon’s novel Against the Day (2006), this thesis examines how the idea of narrative space/time can clarify Pynchon’s use of genre to make socio-political commentary. The first chapter of this thesis focuses on Bakhtin’s “road chronotope,” which is characterized by …

Increased Incidence Of Substance Use And Substance Use Disorders Among Mexicans That Have Migrated To The United States, Emily Hock

Honors Theses

The United States is becoming increasingly older and more racially and ethnically diverse, with Mexican Americans adults aged 65 and over becoming the frontrunners in population growth. Substance use disorders are high among this particular population, with alcohol and tobacco being the most common culprits. Previous research suggests that the prevalence of drinking and smoking among Mexican Americans is increased compared to Mexicans living in Mexico, and substance use rates are highest in those most accustomed to United States culture. While acculturation may initially increase exposure to healthcare options, Mexican Americans are disproportionally uneducated and have lower socioeconomic status than …

Calibration Study Of A Bacterial Quantification Technique Using Transport Swabs And Line Inoculations On Agar Growth Medium, Seth Larue

Honors Theses

Enumeration of bacteria has been the subject of research for over a century. Some of the techniques that have been developed include viable plate counts, the most probable number assessment, and more modern molecular techniques. Many of the newer molecular-based techniques provide little or no information about the viability of the cells being counted, and are generally not quantitative. Having quantitative data for potentially pathogenic bacteria on surfaces can be very useful in many settings, particularly in healthcare facilities. Knowing the numbers of bacterial cells present on surfaces within healthcare facilities may be important to attempt to study the cause …

Discrepancies Amongst Utc Students' Diets And Their Understanding Of Their Role In Environmental Activism, Claire Reticker

Honors Theses

The present research attempts to analyze why university students claim a love for the outdoors but do not use means of dietary action to protect the environment. Through an extensive analysis of corresponding literature, the effects of gender, age, motivation, barriers, and attitudes are examined as they relate to diet. To obtain data regarding these effects, students enrolled in online or hybrid classes at University of Tennessee at Chattanooga (UTC) were sent a survey via Google Forms, with 129 students willingly responding. Previous to survey collection and statistical analysis, I hypothesized that if students rated their love of the outdoors …

Testing For Character Displacement Between Two Abundant Stream Fishes, Amber Nations

Honors Theses

Character displacement is a pattern that can be used to explain differences between similar species in sympatric and allopatric situations. Gause’s Principle explains that a niche can only be occupied by one species at a time, so character displacement may be a way for similar species in the same habitat to shift resource use and compensate in order for the species to coexist. The Southeastern United States offers a unique opportunity to study this pattern because the diversity of freshwater fauna is quite high. However, the question of “How did this region become so diverse?” remains unanswered. One way for …

Environmental Dna (Edna) Surveys For The Smalltooth Sawfish, Pristis Pectinata, In The Chandeleur Islands, Louisiana, Emma M. Humphreys

Honors Theses

The Critically Endangered smalltooth sawfish, Pristis pectinata, was historically found throughout tropical and subtropical coastal waters of the Atlantic Ocean. As a result of mortalities in fisheries and habitat degradation, they became largely restricted to southwest Florida in the U.S. and the Bahamas by the 1980s. However, recent public encounter reports of sawfish in the Florida panhandle, Mississippi, and Louisiana suggest this species is occasionally present in northern Gulf of Mexico waters. Targeted species surveys are needed to improve our understanding of the occurrence and status of this species in these waters. This research used environmental DNA (eDNA) methods …

Differences In Erosion Rates And Elevation Among Natural, Living And Hardened Shorelines In Mississippi, And Alabama, Brittany Juneau

Honors Theses

Shoreline erosion is a phenomenon that currently threatens both natural ecosystems and human settlements along the coast. With trends showing gradual sea level rise as a result of climate change, erosion is becoming an increasing threat to these communities. This research aims to provide more insight into the relationship between shoreline morphology and three shoreline protection techniques: natural marsh, living shoreline, and hardened structures. Six sites along the Alabama and Mississippi coast that had all three shoreline types were evaluated to determine what the average erosion rate and slope was for each shoreline. Erosion rates were calculated by image analysis …

Mentally Restorative Areas For Students: Impacts Of Nature On Psychophysiological State, Jesse Moore

Honors Theses

Situated in the top outdoor ranking city of Chattanooga, the campus of the University of Tennessee at Chattanooga (UTC) includes diverse areas available for student rest and recreation. This study aims to introduce UTC students into the collection of studies on the effects of natural environments on Attention Restoration Theory (ART) by using the Stroop cognitive test and portable electroencephalograph (EEG) headsets. Participants completed the Stroop test after ten-minute mental restoration sessions in environments of varying natural exposure included on campus. Through analysis of variance, location was found to significantly influence performance on Stroop testing and measures of relaxation (p=0.030). …

Literature Review Of Human Hdr Syndrome With Gata3 Haplo Insufficiency, Olivia Ambursley-Gries

Honors Theses

This literature mining project is regarding mutations that cause hearing loss in patients with human hypo parathyroid, deafness, and renal dysplasia (HDR) syndrome caused by a mutation in the GATA3 gene. The disease is unique; not all diagnosed individuals present with all symptoms of the triad. Van Esh et al. found that the haploinsufficiency of the GATA3 is found on chromosome 10p14-p15 (ref.1). The focus of this work is to condense the literature on GATA3 haploinsufficiency correlating to human HDR syndrome. Due to the lack of global healthcare access, it can be assumed that many cases remain undiagnosed; 180 have …

A Theoretical Study Of Synchronous Proton Transfer In (Hf)N, (H2O) N, And (Hcl) N Where N = 3, 4, 5, Johnny Yang

Honors Theses

For (HF)_n, (H₂O)_n, and (HCl)_n (n = 3 − 5), we have rigorously characterized the structures for the minima and transition states for synchronous proton transfer (SPT) with the CCSD(T) method and aug-cc-pVTZ basis set. The electronic barrier heights (∆E^†) associated with these transition states have also been computed with the explicitly correlated CCSD(T)-F12 method and the aug-cc-pVQZ-F12 basis set (abbreviated aQZ-F12). (HCl)_n (n = 3 − 5) SPT transition states have not been previously identified to the best of our knowledge, and they have been found …

Exploring Secondary Metabolite Profiles Of Sloth Algae, Valerie Quach, Paige Smith

Honors Theses

In this experiment, we investigated the composition of the secondary metabolites in sloth algal cultures. Additionally, we investigated the effects of secondary metabolites in sloth algal cultures on insects. The three outlets of investigation include insect avoidance tests, sending samples to the Natural Center for Natural Products Research, and analyzing sequencing data with AntiSMASH to identify secondary metabolite biosynthetic gene clusters. While our data from the Drosophila fly tests were inconclusive, we found that our samples contain many different gene clusters for terpenes, NRPS, PKS, RiPPs, which are volatile compounds with a wide array of biosynthetic functions. This research can …

Amino Acid Composition Analysis As A Means To Differentiate Hair Samples From Individuals Of Similar Demographics And The Effect Of Hair Treatments, Trisha Brady

Honors Theses

Hair is a forensically-relevant exhibit due to its ability to be shed, torn, or transferred during a crime. Current forensic hair analysis includes microscopic hair comparison and mitochondrial or nuclear DNA analyses, each with limitations. Novel methods, such as those evaluated herein, have potential to complement conventional techniques. These include evaluating functional groups with infrared (IR) spectroscopy, elements with laser induced breakdown spectroscopy (LIBS), and amino acid ratios with gas chromatography- mass spectrometry (GC-MS). Hair from two demographically similar individuals was divided into three sample groups per individual: untreated, bleached, and dyed. Spectral differences between individuals and treatments were evaluated …

Evaluation Of The Effect Of The Humic Acid Inhibitor On Forensic Genetic Investigations Of Human Skeletal Remains, Madeline King

Honors Theses

Postmortem survival of DNA in human skeletal remains occurs due to the compact microstructure of the skeleton and its ability to provide a strong, protective physical barrier to environmental insults. On a molecular level, DNA preservation in bones/teeth involves electrostatic interactions between the negatively-charged DNA backbone and positively charged calcium residues in hydroxyapatite, the latter of which is one of the main components of bone microstructure. Despite these protections, over time endogenous DNA becomes damaged, limiting our ability to detect it and affecting its utility in making a positive identification. Hence, forensic genetic investigations of unidentified human remains (UHRs) are …