Digital Commons Network^™

The Spectre Of “Overpopulation” In Climate Change, Kris Mann

Honors Theses

Malthusian overpopulation remains a popular idea across the globe as something that needs to be combated, especially with the anthropogenic impact on the environment. The central guiding question is: To what extent is “overpopulation” a valid notion with regards to the present climate crisis, and should action be taken regarding population reduction? This research concludes that the notion of overpopulation itself is racist, classist, and has caused senseless amounts of suffering in its wake. The inherent notion of overpopulation can only be reductively applied to our current global status with regards to fighting climate change. While the climate crisis is …

The Mechanistic Basis For The Toxicity Difference Between Juvenile Rats And Mice Following Exposure To The Agricultural Insecticide Chlorpyrifos, Katelyn Sette

Honors Theses

No abstract provided.

Assay Development For Investigating The Contributions Of P75 Neurotrophin Receptor (P75ntr) Signaling To Neurodegeneration Associated With Parkinson’S Disease, Samantha A. Radomski

Honors Theses

The p75 neurotrophin receptor (p75^NTR) possesses the ability to promote cell survival or apoptosis upon activation. The specific signaling cascades regulated by p75^NTR in neurodegenerative pathologies are poorly understood due to the multifaceted nature of the receptor. Prior studies associate oxidative stress, a cellular condition induced by an overwhelming presence of reactive oxygen species, with promoting proteolysis and subsequent activation of p75^NTR in dopaminergic neurons. Dopaminergic neurons express p75^NTR and are of interest in neurodegenerative research. The degeneration of these neurons occur during the progression of Parkinson’s Disease. Here, we optimized an in vivo and …

Nectar Source Preferences Of The Hummingbird: A Field Study From South Texas, Jasmine Benavidez

Honors Theses

With the rise of urbanization, comes a rise in urban-like activities—most notable is birdfeeding. Given the increasing popularity of bird-feeding, especially in hummingbird feeding, concern for implications, if any, has mounted. There is reason to believe that artificial feeders can impact the surrounding environment; that is, it is possible that feeders could attract pollinators away from flowering plants, which, in turn, could bring repercussions for pollination and all associated with it. However, literature, on the matter, is rather limited. To add to this, past studies provide two opposing arguments. This study aims to explore the nectar source preferences of hummingbirds …

Establishing A Drosophila Colon Cancer Model To Study Interactions And Therapeutic Targets Of Oncogenic Pathways, Kathleen T. Mccaslin

Honors Theses

The objective of this project is to develop an in vivo colorectal cancer (CRC) model in Drosophila melanogaster to test the role of Ras and Wnt pathways in gastrointestinal cancer as potential therapeutic targets. To do so, we have (a) developed a CRC model in flies, (b) tested the levels of Ras and Wnt pathway activity in this model, and (c) will use drugs to find inhibitors of these pathways. Using fly mutants and transgenic flies we have created small patches of cancerous cells in the fly intestine in which have activated oncogenic Ras (mutation RasV12) and dominant negative p53 …

The Impact Of Anaerobic Exposure And Propionate On The Kinetics And Pathogenesis Of Listeria Monocytogenes, Mackenzie T. Martin

Honors Theses

Listeria monocytogenes is a foodborne pathogen commonly found in ready-to-eat deli and dairy products. This foodborne pathogen is responsible for the disease listeriosis, which disproportionately impacts immunocompromised individuals. This research aims to evaluate how natural intestinal environments influence the pathogenesis of Listeria. One particular environmental condition that has a well-documented effect on Listeria is varying levels of oxygen. Specifically, anaerobic exposure during the growth of Listeria greatly impacts subsequent intracellular pathogenesis. When grown and adapted under anaerobic conditions, Listeria overall exhibits decreased intracellular survival and decreased cell to cell spread. However, the presence of propionate, a natural byproduct of fermentation …

Narratives Of The Black Mother In The U.S.: Exploring The Black Maternalist Framework In Black Activism, Anna Biesecker-Mast

Honors Theses

My historical research seeks to reveal how exactly White European notions of Blackness, womanhood, and motherhood (and the intersections of all three) were inscribed onto the lived experiences of enslaved women and mothers from the early Atlantic period through the antebellum era. What emerges from a critical analysis of archival omissions are Black women’s voices and experiences—who demonstrate over and over that they resisted and are resisting. I will demonstrate how other people’s rhetorical use of Black motherhood constructs and shapes the lived experience of these women and creates a tension between the ‘ideal’ Black mother and those that don’t …

Microwave-Assisted Synthesis Of Quinoxaline Derivatives, Eric Horsting

Honors Theses

Quinoxaline and its derivatives have been studied extensively for their relevant biological activity and transition metal selectivity. These compounds are commonly used for their antimicrobial, antifungal, antiparasitic activity, and relevance in the treatment of metabolic diseases [6]. More recently, quinoxaline’s ability to inhibit gram-positive bacterial growth has been found especially in oxygen- containing compounds, yielding promising candidates to prevent cancerous tumor growth [5]. The breadth of quinoxaline makes it a valuable tool within the research community However, its synthesis requires complex solvents, extended reaction times, and often produces a low yield. By using a microwave-assisted synthesis, this novel methodology offers …

Dayton Is Burning: A Survey Of Drag History And Performance In Southwest And Central Ohio, Katie Schreyer

Honors Theses

The history of gender performance is long and complex, spanning across different times and places that are each fascinating in their right and worth being studied. This thesis focuses specifically on the drag performances that take place in and around Dayton, Ohio. The research presented here is based on explorations of two distinct time periods 100 years apart from each other, the turn of the 20th century and the modern day. These two distinct times and cultures are each characterized by the performances that occurred, how they were received by audiences, the identities of the performers and the degree of …

Independent Investigations Of The Relationships Between Altruistic Behavior And Empathy With Depression, Colton Watson

Honors Theses

Depressive symptoms can influence a variety of individual factors, including altruism and empathy. The nature of that relationship, however, is poorly understood. Cross-sectional studies examining the empathetic and altruistic abilities of people with varying levels of depressive symptoms have produced mixed results, as both the magnitude and direction of any correlations between empathy or altruism and depression are varied. Thus, we aimed to examine the impact of depressive symptoms on self-report measures of altruistic behavior and empathy. Using the Quick Inventory of Depressive Symptoms-Self Report (QIDS-SR) to measure depressive symptoms, the Interpersonal Reactivity Index (IRI) to measure empathy, and the …

Substituent Effect Analysis Of The Synthesis Of 1-Azabicyclo[2.2.1]Heptan-2-One Using Diels-Alder Reactions, Vida Robertson

Honors Theses

No abstract provided.

A Starling In A Pear Tree: Assessing The Influence Of Bird Dispersal On Callery Pear (Pyrus Calleryana), Olivia Clark

Honors Theses

Invasive species can disrupt ecosystems and negatively affect other species. Callery pear (Pyrus calleryana) is an invasive ornamental tree that is spreading quickly throughout the United States. It is possible that birds are responsible for spreading Callery pear by eating the fruit and depositing seeds in new areas. European starlings (Sturnus vulgaris) and American robins (Turdus migratorius) are mentioned in most studies as responsible for the dispersal of Callery pear. However, there is also evidence that Cedar waxwings (Bombycilla cedrorum) also feed on the tree. Invasive plants can impact avian health, reproduction, and migration. Additionally, there are many aspects of …

In Other Words, Socialized Medicine: Journal Of The American Medical Association Versus The International Labour Organization, Tanner Deyoung

Honors Theses

In the summer of 1952, the International Labour Organization—an agency of the United Nations—adopted the Social Security (Minimum Standards) Convention. It detailed and defined the minimum acceptable standards for social security in nine different areas, including medical care, in the nations which ratified the convention. However, in order to ratify the convention, nations need only prove compliance with four of the nine areas, possibly eliminating medical care reform entirely. This provision did not prevent the American Medical Association, through its published journal, from attacking the recommendations related to healthcare as “socialized medicine.” Through these attacks, the AMA continued its pattern …

Pro-Understanding: Understanding The Pro-Choice Catholic, Natalie Eilerman

Honors Theses

Abortion is a widely debated and polarizing topic in the United States. While many Catholic leaders and members tend to hold beliefs against abortion, some Catholics are pro-choice. This study explores the perspectives and experiences of this often-under-recognized group. Mixed methods research was conducted to analyze 1) how perspectives towards abortion are changing among Catholics in the United States (using data from the General Social Survey from 1977-2018), and 2) the experiences of college students at a private, predominately white, Catholic university in the Midwest who identify as pro-choice and Catholic. Quantitative analysis shows that Catholics’ attitudes towards abortion are …

Ain't No Sunshine When They're Gone: Pollinators In A Solar Prarie, Brigid M. Morgan

Honors Theses

Around the world, pollinator populations are decreasing due to climate change, habitat loss and fragmentation, invasive species, pesticide use, and disease. A solar prairie can provide that habitat space with native plants to attract and promote the growth of native pollinator populations. In this study at the University of Dayton in Dayton, Ohio, I sought to find out if native pollinators were using the habitats inside and around the solar panels at Curran Place. By using pan traps weekly throughout the summer months to collect the insects, I found that native pollinators are using the habitats between the rows of …

Evaluation Of Patellar Tendon Load Across Sports-Related Activities, Breven Perry

Honors Theses

Osgood Schlatter’s Disease (OSD) is a disease that results in a painful inflammation of the tibial tuberosity caused from overuse of the knee as the apophyseal growth plate is continuing to close in adolescence. As this condition arises from too much tension on a closing growth plate, it is most prevalent in children 8-15 years old, and especially common in athletes. The purpose of this study is to examine the peak patellar tendon force experienced from a variety of movements common in sport. 30 subjects performed a walk, run, hop, single-leg hop (SLH), countermovement jump (CMJ), single-leg CMJ, drop vertical …

Defining The Leading Edge Of The Marine – Non-Marine Transition In The Pee Dee Basin: Influences, And Dynamic Parameters Of A Highly Dynamic System, Nicole Mchugh

Honors Theses

Among estuaries, there is a large block of co-dependent and independent variables shaping habitat and environmental conditions within a critical area. Historical data proxies and indexes from seven different stations were assessed to consider temporal and spatial variability of the marine and non-marine transition along the South Carolina Pee Dee River Basin. Historical datasets from the upper reaches of Winyah Bay and lower section of the Pee Dee River basin were compiled along with shorter termed deployments of a new instrument station installed near Georgetown, SC. This area is representative of the marine-non-marine transition in drowned river mouth estuaries. Water …

Synthesis Of Alpha Domain Of Metallothionein For Hydrogen Production, Aditya Surakanti

Honors Theses

The world relies on nonrenewable resources for a significant portion of its usable energy, the most common being fossil fuels. Fossil fuels release many unwanted byproducts during their extractions and conversion processes. As a result, this excessive use leads to harsh consequences upon the environment, including rapid global warming, release of numerous water and air pollutants, and it could possibly lead to an increased risk of death in those who are exposed to these toxins. In response to this scenario, the goal of my project is to design an artificial hydrogen catalyst, which can absorb sunlight and oxidize H2O into …

Providing Culturally Competent Eldercare For Asian Americans, Britney Ngo

Honors Theses

As the Asian American elderly population continues to grow, it is important to acknowledge cultural factors that may impact their behavior, attitudes, preferences, and decisions in the context of eldercare. Cultural competency acknowledges and considers these factors while providing care that includes biophysical factors of healthcare as well as non-medical dimensions of care such as language and culture.

This thesis seeks to address the applications of providing culturally competent eldercare to Asian Americans and offer future recommendations to care settings that have limited resources by utilizing a multidisciplinary review of literature accompanied by interviews with representatives from On Lok, a …

The Role Of The Prodomain In The Folding Of Carboxypeptidase A1, Masy Domecillo

Honors Theses

Carboxypeptidase A1 (CPA1) is an enzyme utilized in digestion. CPA1 contains a prodomain region, which must be cleaved for enzymatic function. The prodomain region has been hypothesized to be necessary for structural stability, as previous studies were unable to produce a functional CPA1 protein without the prodomain region. However, the recent discovery of a related enzyme, Carboxypeptidase 0 (CP0), which does not have a prodomain yet functions enzymatically, challenges this assertion. To determine if the prodomain is essential to the folding of CPA1, an HA-tag was added for detection, and the prodomain was deleted via PCR. A Western blot was …

Interspecific And Ontogenic Differences In The Molar Occlusal Surfaces Of Manatees (Sirenia: Trichechidae), Lyle Goulbourne

Honors Theses

While much is known regarding limitless horizontal replacement of manatee teeth, the morphology and topography of the teeth have not been formally described, nor have interspecific differences and ontogenic changes in relative tooth size been described in detail. To physically describe the teeth, photographs of the molars from West Indian manatees (Trichechus manatus) and Amazonian manatees (T. inunguis) were taken and the features of the teeth were identified. To compare tooth size differences, the area of the posterior-most molar in occlusion was measured from both the upper and lower molars of the manatee skulls from West Indian and Amazonian manatees. …

Analysis Of Invasion Proteins Mmp2, Mmp9, Adam12, And Adam17 In Glioblastoma U87mg Cells Treated With Anti-Cancer Compound 3,4-Dimethoxybenzaldehyde, Andras Muranyi

Honors Theses

This research tested the effectiveness of novel compound 3,4-dimethoxybenzaldehyde, demonstrated to have anti-cancer properties. U87MG Glioblastoma cells were exposed to the compound at its LC50 concentration, then processed to collect proteins from the cells. Proteins were analyzed via Western blotting for specific protein levels of matrix metalloproteinase 2 and 9 (MMP) and disintegrin and metalloprotease 12 and 17 (ADAM). Previous research indicates these proteins are involved in the invasive properties of glioblastoma cells. Westerns were quantified with ImageJ and compared using a one-way ANOVA. Results indicate the compound has minimal effect upon the expression of MMP2, MMP9, ADAM12, ADAM17 proteins.

Classifying Pretzel Links Obtained By Strong Fusion, Jonathan Homan

Honors Theses

A link is a collection of circles embedded into 3-dimensional space. Pretzel links are an important family of links which comprises those links that fit a general form that includes many of the most common links. The strong fusion of a link joins two components of the link via a band and adds an unknotted circle about the band [4]; this naturally arises in the study of concordance and has been used to model biological phenomena such as site specific recombination in DNA [2]. Here we present a complete and original classification of those pretzel links which can be obtained …

"A Woman's Lot To Suffer" : Recognizing The Intersectionality Of Oppression And Resistance In Min Jin Lee's Pachinko, Elianna Srikureja

Honors Theses

Min Jin Lee's novel Pachinko (2017) portrays the historically based lives of a displaced Korean family during Japan's colonization of Korea from 1905-1945. The novel's attention to the ways that colonial endeavors complicate Confucian family and national structures exemplifies the interrelation between gender and racial oppression facing Lee's Korean women in both the public and private domain.

However, by centering female voices all too often silenced, Lee also depicts resistance modes that subvert such oppression. Using feminist and postcolonial theory, historical analysis, and close reading analysis, this project examines both the construction of oppression and the subversive resistance measures taken …

Phonotactic Tuning In Female Cricket Acheta Domesticus, Jessica Rim

Honors Theses

Phonotactic behavior of female cricket Acheta domesticus has been shown to vary among individuals. While some females are finely tuned to calls with syllable periods in the natural range of conspecific males, others respond phonotactically to a wider range of syllable periods and therefore lack the ability to discriminate between attractive and unattractive calls. When females are exposed to males but prevented from mating, their ability to discriminate attractive calls is reduced, suggesting that factors other than mating alter phonotactic behavior. This study evaluated the effect of male exposure on females’ phonotactic tuning and responsiveness in relation to underlying neural …

Reassessing The Parameters Of Phonotaxis In Female Acheta Domesticus, Jewel Murray

Honors Theses

To study phonotaxis in crickets a trackball system has been traditionally used, which consists of a spherical, air supported styrofoam ball placed in a soundproof container in which crickets are tethered to. Two computer mice detect its movement. A speaker is at one end of the container, and it is connected to a computer which generates calls with pre-set parameters. Once a cricket is attached to the trackball system, it can freely navigate toward the source of the sound, while the styrofoam ball remains stationary.

This apparatus has been used to measure the walking distance and angular orientation. When evaluating …

Phonotactic Tuning In Female Cricket Acheta Domesticus, Jessica Rim

Honors Theses

Phonotactic behavior of female cricket Acheta domesticus has been shown to vary among individuals. While some females are finely tuned to calls with syllable periods in the natural range of conspecific males, others respond phonotactically to a wider range of syllable periods and therefore lack the ability to discriminate between attractive and unattractive calls. When females are exposed to males but prevented from mating, their ability to discriminate attractive calls is reduced, suggesting that factors other than mating alter phonotactic behavior.

This study evaluated the effect of male exposure on females’ phonotactic tuning and responsiveness in relation to underlying neural …

Attempted Synthesis & Antibacterial Properties Of Apt-6k Against Ndm-1 K. Pneumoniae, Alec Bofetiado

Honors Theses

NDM-1 K. pneumoniae is a highly resistant bacterial organism that is capable of causing debilitating nosocomial infections in immunocompromised patients. Only "last-resort" antibiotics--such as colistin--work against this organism. Therefore, new antibiotics are needed to help fight against these types of infections. APT-6K is a novel compound that was demonstrated to be effective against MRSA with nanomolar concentrations in a prior study. Novel methods of APT-6K synthesis and its testing for antibiotic effects against NDM-1 K. pneumoniae were attempted in this research. APT-6K synthesis was unsuccessful. Commercially-prepared APT-6K also did not demonstrate growth inhibition against NDM-1 K. pneumoniae nor against a …

Gene Expression Of Stress-Related Biomarkers And Disease Presence In Gene Expression Of Stress-Related Biomarkers And Disease Presence In Crassostrea Virginica, Jaycie Keylon

Honors Theses

Crassostrea virginica, the Eastern oyster, is an environmentally and economically important species along the East coast and in the Gulf of Mexico. Environmentally, oysters are filter feeders, cleaning the water of contaminants. They also provide habitat and shelter for other marine species. Oysters are of significant economic value as seafood to nearby communities as well. Eastern oyster populations have been significantly adversely affected by the parasite Perkinsus marinus, which causes Dermo disease. Dermo affects oysters during times of warm temperatures and high salinities and has the potential to wipe out entire populations of oysters. Throughout this study, the …

Developing A Circuit Model To Study The Mechanisms Of Dna Damage And Repair Feedback Dynamics In Cancer Cells, Thomas M. Deangelo

Honors Theses

Cancer therapies over the last decade have promoted a growing interest in the manipulation of DNA damage and repair pathways due to its beneficial consequences on cancer cell viability. Simultaneously attacking genetic code with DNA-damaging chemotherapies while eliminating mechanisms of DNA repair – the protectors of our genome – has enormous therapeutic potential. Biological circuit engineering interfaces biochemistry and systems biology with electrical engineering analyses to accurately model and simulate biological pathways such as DNA damage and repair. Circuit models can also be used to identify weaknesses within pathways, highlighting the most efficient protein targets for drugs that aim to …