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Articles 4681 - 4710 of 5931
Full-Text Articles in Entire DC Network
Novel Neuroprotective Function Of Apical-Basal Polarity Gene Crumbs In Amyloid Beta 42 (Aβ42) Mediated Neurodegeneration, Andrew Steffensmeier
Novel Neuroprotective Function Of Apical-Basal Polarity Gene Crumbs In Amyloid Beta 42 (Aβ42) Mediated Neurodegeneration, Andrew Steffensmeier
Honors Theses
Alzheimer’s disease (AD, OMIM: 104300), a progressive neurodegenerative disorder with no cure to date, is caused by the generation of amyloid-beta-42 (Aβ42) aggregates that trigger neuronal cell death by unknown mechanism(s). We have developed a transgenic Drosophila eye model where misexpression of human Aβ42 results in AD like neuropathology in the neural retina. We have identified an apical-basal polarity gene crumbs (crb) as a genetic modifier of Aβ42-mediated-neuropathology. Misexpression of Aβ42 caused upregulation of Crb expression, whereas, downregulation of Crb either by RNAi or null allele approach rescued the Aβ42-mediated-neurodegeneration. Co-expression of full length Crb with Aβ42 increased severity …
The Dayton Food System: Current Access To Food In Dayton And Future Possibilities, Katherine A. Liutkus
The Dayton Food System: Current Access To Food In Dayton And Future Possibilities, Katherine A. Liutkus
Honors Theses
Downtown Dayton and its surrounding areas are considered to be a food desert by the USDA, which means there is limited access to healthy foods within a .5 mile radius. The implications of this include driving further for groceries or turning to convenience stores for highly processed foods. This has created health concerns for the residents of Dayton, including obesity and diabetes. The purpose of this study was to understand the food system issues, their complexity and implications, and to understand what groups are currently doing to support the food system, and what is necessary to push the issues forward …
Designing And Evaluating Playground Equipment For Compliance With The Americans With Disabilities Act, Leigha R. Brisco
Designing And Evaluating Playground Equipment For Compliance With The Americans With Disabilities Act, Leigha R. Brisco
Honors Theses
The need for accessible playgrounds is more prevalent than ever before, with approximately 3 million children having disabilities and health issues that limit their ability to partake in play and school. The Americans with Disabilities Act (ADA) recently provided, for the first time, specific accessible design standards for playgrounds. All playgrounds must now comply with these rules that went into place on March 15, 2012. As it is vital that playgrounds undergo the necessary changes to come up to compliance, there is an opportunity to develop an accessible playground design which satisfies all ADA playground standards and requirements. The objective …
Resettled: A Portrait Of Bhutanese Refugees In Dayton, Ohio, Molly R. Winslow
Resettled: A Portrait Of Bhutanese Refugees In Dayton, Ohio, Molly R. Winslow
Honors Theses
75 Bhutanese refugees have been resettled in Dayton, Ohio. Through an intensive case study with one Bhutanese refugee family and interviews with local refugee service providers the topics of English language acquisition, issues surrounding the job search and religion as both a community builder and insulator are examined.
Tissi, Anna Demmitt
Tissi, Anna Demmitt
Honors Theses
Tissi is a series of short stories depicting the lives of children living in Sudan through the genocide. There are three stories of pain and suffering that depict the lives of Yaya, Abit, and Tahir. Each child is forced to deal with the ill effects of the genocide. The stories conclude with a story of hope of one child who was able to get help in a refugee camp located in Tissi.
Discrimination Against Disabled Persons In Malawi And The United States: A Comparative Study, Stephen Crum
Discrimination Against Disabled Persons In Malawi And The United States: A Comparative Study, Stephen Crum
Honors Theses
Physically disabled individuals experience hardships that are more severe than the general public in both Malawi, African and in the United States. Disabled Malawians and Americans experience lower employment rates and lower annual incomes than the general public. Additionally, there is a lower educational attendance rate among disabled individuals in each country. This study sought to determine what factors contributed to these educational and employment deficiencies in both countries. Possible factors for the deficit may include discrimination, poor infrastructure, or the severity of the physical disability. A survey was administered to students (N = 52) at the University of Dayton …
Examining Acculturative Stressors Of The International Student: Following Study Abroad Students In South Korea And Morocco, Chin Yi Chen
Examining Acculturative Stressors Of The International Student: Following Study Abroad Students In South Korea And Morocco, Chin Yi Chen
Honors Theses
International students, particularly students studying abroad for a limited period of time, face certain challenges in entering and adjusting to a new cultural environment. This research focuses on different acculturative stressors including language, differences in nonverbal communication, discrimination, and academic pressure. By comparing and contrasting the perspectives of various students with the researcher’s experience, this qualitative study provides insight into the lived experience of international students and the research through on-site fieldwork conducted over a year on university campuses in South Korea and Morocco. It discusses the results of the undertaken research and offers suggestions for resolving or minimizing these …
Transit As An Alternative Mode Of Transportation: A Case Study Of Its Usage, Availability, Patterns And Value For Non-Commuter Trips, Sara Hardman
Honors Theses
The mode of transportation a user picks impacts the environment, the social environment, and the user himself/herself. While research on alternative modes of transportation is prevalent in both the engineering and sociology fields, little attention has been given to the choices people make concerning how they run errands and other social trips, focusing instead on commuter trips. This case study examines three different shopping malls and the surrounding bus stops in order to determine the role distance plays in bus usage and the value that shopping centers place on access to local bus routes. Determination of the value and potential …
Sex-Dependent Electrophysiological Responses Of Lucilia Sericata To Concentration Gradient Of Indole, Erin T. Filbrandt
Sex-Dependent Electrophysiological Responses Of Lucilia Sericata To Concentration Gradient Of Indole, Erin T. Filbrandt
Honors Theses
I investigated the responses to specific concentrations of indole in the adult stage of Lucilia sericata, the common green bottle fly. Indole is a commonly used attractant at concentrations between 0 and .04% that has a floral scent at low concentrations and a fecal odor at high concentrations (Cragg, 1950). There were three treatment cages: one all male, one all female, and one mixed male and female. The purpose of these conditions was to observe the difference between sensory responses of males, non-mated females, and mated females. All cages were placed in an incubator to maintain uniform temperatures and …
Impact Of Amur Honeysuckle (Lonicera Maackii) Leachate On Culex Pipiens Life History Attributes, Lauren Shewhart
Impact Of Amur Honeysuckle (Lonicera Maackii) Leachate On Culex Pipiens Life History Attributes, Lauren Shewhart
Honors Theses
The purpose of this study was to look at the impact of a highly invasive plant, Lonicera maackii, on the primary vector of West Nile Virus in the Eastern United States, Culex pipiens. Three different assays using two different microcosms experiments were conducted to determine the rate of survivorship, pupation, emergence, and larval growth of mosquito larvae in native (Platanus occidentalis and Acer saccharum) and invasive (L. maackii leaf and flower) leachates. It was found that L. maackii has the potential to increase mosquito populations due to the fast decaying nature of its leaves and …
Investigating Bacterial Replication Restart: Can D.Rad Pria Load D.Rad Dnab Onto Dna Forks With A Leading Strand Gap?, Michael Ryan
Investigating Bacterial Replication Restart: Can D.Rad Pria Load D.Rad Dnab Onto Dna Forks With A Leading Strand Gap?, Michael Ryan
Honors Theses
The bacteria Deinococcus radiodurans (D. rad) is able to survive multiple double stranded breaks to its DNA with no detriment to its health as its genome can be fully repaired in a matter of hours. During bacterial DNA replication, points of DNA damage can cause replication to cease, requiring an origin independent replisome loading pathway to resume the replication. This pathway is called replication restart , a highly conserved pathway in bacteria. In the E. coli replication restart pathway primosome proteins function by binding to the DNA fork and facilitating the loading of the DnaB helicase onto the replication fork. …
Epinephrine Regulates Aquaglyceroporin Hc-3 Expression And Subcellular Localization In Cultured Erythrocytes From The Freeze-Tolerant Treefrog, Hyla Chrysoscelis, Connor J. Ratycz
Epinephrine Regulates Aquaglyceroporin Hc-3 Expression And Subcellular Localization In Cultured Erythrocytes From The Freeze-Tolerant Treefrog, Hyla Chrysoscelis, Connor J. Ratycz
Honors Theses
Cope’s gray treefrog Hyla chrysoscelis, accumulates and distributes glycerol as a cryoprotectant in anticipation of freezing. Transmembrane glycerol and water flux in H. chysoscelis erythrocytes likely occurs through HC-3, an ortholog of mammalian aquaporin 3. HC-3 protein is in higher abundance and is preferentially localized to the plasma membrane in RBCs from cold-acclimated treefrogs as compared to warmacclimated animals. It is hypothesized that neuroendocrine agonists via receptor mediated second messenger pathways integrate signals derived from fasting, dehydration, diurnal, and/or temperature changes during cold-acclimation to regulate HC-3 expression as part of the mechanism of freeze tolerance. In this study, cultured …
The Acute Effects Of Aerobic And Resistance Exercise On Cardiovascular Function And Arterial Stiffness, Hayleigh Elizabeth Raiff
The Acute Effects Of Aerobic And Resistance Exercise On Cardiovascular Function And Arterial Stiffness, Hayleigh Elizabeth Raiff
Honors Theses
The cardiovascular system changes acutely to the stresses of exercise to support the increased metabolic demand of the working tissues. This is accomplished through the augmentation of several parameters including heart rate, blood pressure, and vascular tone such as arterial stiffness. Exercise training has been shown to elicit changes in arterial stiffness but the acute effects of exercise on arterial stiffness have not been thoroughly studied. The current study examined the acute effects of no (control), aerobic (30 minutes of cycling at ~70% maximum heart rate), and resistance exercise (30 minutes, 3 sets of 10 repetitions for 6 exercises) on …
As Stable As The Dollar Stretches: The Impact Of Us Foreign Aid On Social Stability In Jordan, Jasmine Renee Jordan
As Stable As The Dollar Stretches: The Impact Of Us Foreign Aid On Social Stability In Jordan, Jasmine Renee Jordan
Honors Theses
After the fall out of the Arab Spring in 2010, most of the countries in the Middle East and North Africa region suffered from extreme political, social, and economical instability. Usually, the citizens of these counties were revolting against the authoritarian regimes that have held power for decades. Jordan stands as the only obvious exception. How has Jordan maintained relative economic stability where others have failed? I have found that it is hard to judge the economic or social stability of Jordan without recognizing the large amounts of foreign aid Jordan has received from the US. This thesis asks what …
The Themes Of Catholic Social Teaching Integrated Into The Work Of Ud’S Center For Catholic Education Urban Child Development Resource Center, Julie Iuliano
Honors Theses
Schools today are challenged to meet the mental health concerns of students due to an emphasis on academic testing and a lack of communication within schools to identify and treat the needs of the students. The needs of the student travel beyond the classroom into the non-academic barriers to learning. The University of Dayton’s Urban Child Development Resource Center (UCDRC), works in five local schools in the Dayton area and strives to help students cope with these non-academic barriers to learning. This study focuses on three of the Seven Themes of Catholic Social Teaching as stated by the United States …
Auditory Information In The Form Of A Scratching Sound Enhances The Effects Of The Rubber Hand Illusion, Bridget O'Mera
Auditory Information In The Form Of A Scratching Sound Enhances The Effects Of The Rubber Hand Illusion, Bridget O'Mera
Honors Theses
The body schema describes an internal representation of the body in space, and is generated from a number of different sense modalities such as vision and proprioception. Botvinick and Cohen's rubber hand illusion (1998) demonstrates the relative contributions of vision, tactile perception and proprioception to body awareness. In this illusion, a participant's real hand is concealed from view and a prosthetic rubber hand is seen in its place. An experimenter simultaneously administers tactile stimulation to both the seen rubber hand and participant's actual hidden hand. The combination of this visual and tactile information overrides proprioceptive cues to body perception, creating …
!Que Aproveche! An American Student's Encounter With The Culture And Language Of Spanish Food, Amanda Mills
!Que Aproveche! An American Student's Encounter With The Culture And Language Of Spanish Food, Amanda Mills
Honors Theses
As a language teacher, culture is one of the most challenging things to convey to students. It is relatively straightforward to introduce grammar and vocabulary, but culture is an entirely different topic, one that adds a level of complexity that is difficult to describe and harder to convey. I wish I could give students a living, breathing experience of what it is like to visit or live in a Spanish-speaking country, but school budgets and instructional hours typically do not allow for that. To apply my knowledge of Spanish and make it accessible and meaningful to students, I designed a …
Protestantism, Liberalism, And Racial Equality, Abraham Uppal
Protestantism, Liberalism, And Racial Equality, Abraham Uppal
Honors Theses
In this paper, I will examine liberalism in Protestantism. Liberals who are Protestant, Mainline Protestants, are an interesting group who are different from the conservative, Evangelical Christian crowd. I will pay special attention to racial issues like affirmative action and racism. Liberalism in Protestantism is often called the social gospel, a theology in which Protestants believe Christian teachings mandate an active role in society in which values such as freedom, equality, and love are pursued. The social gospel contrasts with the theology called individual salvation, often identified with conservative or Evangelical Christianity, in which one’s personal relationship with God is …
Language Trends Of Spanish/English Dual Language Learners, Cailin Amundsen
Language Trends Of Spanish/English Dual Language Learners, Cailin Amundsen
Honors Theses
This honors thesis project explores past and current research on the language and literacy development and assessment of Spanish-English bilinguals. The researched differences between Spanish and English language acquisition, cross-language development patterns and phenomena found in bilingual children, and holistic approaches to accurate and authentic assessment of language acquisition of bilinguals have lent support to future research questions and methodologies. The following literature review provides clear connections from current bilingual language acquisition and literacy development studies to the future research questions and ideas they rouse. Said questions and ideas have been organized into a research proposal addressing the language trends …
Optimization Of A Chemical Genetic Screen To Identify Druggable Targets In U138 Cells Treated With Laromustine, Kathryn Coe
Optimization Of A Chemical Genetic Screen To Identify Druggable Targets In U138 Cells Treated With Laromustine, Kathryn Coe
Honors Theses
Laromustine is an experimental sulfonylhydrazine prodrug used in late-stage clinical studies against acute myeloid leukemia (AML) and glioblastoma multiforme (GBM). Despite initial promise for both indications, clinical trials for GBM have not been as successful as those for AML. To investigate methods for improving the effectiveness of laromustine in GBM and to learn more about the mechanism of action of laromustine, a chemical genetic screen will be conducted to identify agents that sensitize GBM cells to the anti-proliferative effects of laromustine. The library, which will include approximately 450 FDA-approved drugs, will be screened using a newly optimized high throughput assay …
Influence Of The Sea Surface Microlayer On Ozone Deposition Velocity, Kathryn Moore
Influence Of The Sea Surface Microlayer On Ozone Deposition Velocity, Kathryn Moore
Honors Theses
The biogeochemical cycles of both iodine and ozone are strongly linked to human health and global climate and are tightly coupled through chemical processes occurring in the surface ocean and troposphere. The concentration and distribution of these compounds have the potential to drive the oxidizing capacity and suite of chemical reactions occurring in the marine boundary layer. However, modeling coupled ocean-atmosphere systems involving them is challenging because of a limited understanding of the magnitude and dominant mechanisms controlling the fluxes of both species, in addition to temporally and spatially heterogeneous distributions of ozone and iodine in the sea surface and …
The Role Of Underutilized Fish In New England's Seafood System, Taylor Witkin
The Role Of Underutilized Fish In New England's Seafood System, Taylor Witkin
Honors Theses
The global fisheries crisis has led to an increasing recognition for the need to relieve pressure on overfished, popular food fish stocks. Opportunities exist to shift consumer demand toward more sustainable choices, including fish that may be locally abundant. Attempts have been made to market underused fish (sometimes termed “trash fish”) that represent more sustainable alternatives; however, it is unclear whether consumers will choose to purchase these more sustainable options, particularly if underused fish are also unfamiliar. Chapter 1 reviews existing research and current issues surrounding sustainable seafood and the recent shift toward local, abundant, undervalued species in New England’s …
The Relationships Between Local Food And Food Security In Maine, Erin Love
The Relationships Between Local Food And Food Security In Maine, Erin Love
Honors Theses
There is a food systems paradox in Maine: the State has one of the highest levels of food insecurity in the nation, while simultaneously experiencing a local agriculture boom. Maine has some of the largest percentages of young farmers and women farmers in the country and is home to the second highest number of artisan cheese makers of any state in the country. Amidst this exciting, sometimes quirky, agricultural activity there is a critical need for food systems development in the state, especially in the context of serving vulnerable populations. This thesis explores the ways in which Mainers are working …
The Effect Of Azo Textile Dyes On Gross Primary Production And Community Respiration In An Artificial Environment, Theresa L. Petzoldt
The Effect Of Azo Textile Dyes On Gross Primary Production And Community Respiration In An Artificial Environment, Theresa L. Petzoldt
Honors Theses
Azo dyes are the largest category of textile dyes in production today, with over 100,000 tons of dye produced yearly in the United States. Ten to fifty percent of this dye is not fixed to the fabric during the textile production process, and is therefore discarded as effluent. Because dye waste is difficult to process in wastewater treatment facilities, it is important to understand how this waste affects aquatic systems using a whole ecosystem approach. This study used an artificial stream to model the effects of four azo dyes on benthic biofilm production and respiration. Dyes were found to have …
The Impact Of Dams On Nitrogen Cycling In The Messalonskee Stream, Rebecca K. Forgrave
The Impact Of Dams On Nitrogen Cycling In The Messalonskee Stream, Rebecca K. Forgrave
Honors Theses
The Messalonskee Stream in central Maine has five hydroelectric dams on 16.6km. Each dam drastically changes the flow regime of the stream, dividing it into segments with different patterns of sediment settling and organic matter retention. I investigated how these disruptions impact nitrogen cycling, specifically nitrification rates above and below each dam. I expected higher nitrification rates above the dams, where levels of organic matter are higher, and lower rates below the dam where scouring removes organic matter and fine sediment from the streambed. I measured sediment nitrification rates with a nitrapyrin-inhibition assay and potential drivers of nitrification including sediment …
The Economic Impact Of Shale Gas Development: A Natural Experiment Along The New York And Pennsylvania Border, Brendan Cosgrove
The Economic Impact Of Shale Gas Development: A Natural Experiment Along The New York And Pennsylvania Border, Brendan Cosgrove
Honors Theses
In the United States, the rapid increase in shale gas production has recently stimulated local economies. This paper investigates the regional economic impact of shale gas development. The border of New York and Pennsylvania provides a natural experiment for its economic impact because of the moratorium on fracking in NY and the supportive fracking regulations in PA. Using BLS data from 2001-2013, results show that shale gas development has a statistically significant impact at the industry level, but not across the entire economy. The findings contribute new evidence to the economic benefits and the boom-bust cycle of shale gas extraction.
Host-Specialization Of Bartonella In Flea Vectors Collected From Black-Tailed Prairie Dogs, Mark D. Massaro
Host-Specialization Of Bartonella In Flea Vectors Collected From Black-Tailed Prairie Dogs, Mark D. Massaro
Honors Theses
At least 22 species of Bartonella bacteria have been named and many are associated with one of a list of potential mammalian reservoirs and arthropod vectors. One example of such a system is the parasitism of black-tailed prairie dogs (Cynomys ludovicianus) of the Western U.S. by Oropyslla hirsuta and Pulex simulans fleas. These vectors are thought to maintain B. washoensis infection in these mammals, but little is known about their role in the specialization of this strain to this reservoir. We found that the more specialist O. hirsuta fleas were much more likely to be infected with B. washoensis than …
The Case Of "Who's Looney Now?" : Psychologists, Psychiatrists, The Public, And Contested Notions Of Insanity In Turn-Of-The-Twentieth Century America, Amanda Lynn Haislip
The Case Of "Who's Looney Now?" : Psychologists, Psychiatrists, The Public, And Contested Notions Of Insanity In Turn-Of-The-Twentieth Century America, Amanda Lynn Haislip
Honors Theses
No doubt, “eccentric” is one word that describes John Armstrong Chaloner, a lawyer, entrepreneur, anti-Spiritualist, “scientific” medium, millionaire heir to the fur-trading fortune of John Jacob Astor, and, at one point, an incurably insane paranoiac. After he married and amicably divorced the Virginian novelist Amélie Rives, in 1888 and 1895 respectively, Chaloner discovered he could communicate with his subconscious, his “X-Faculty” as he named it, using a planchette, an early form of a Ouija board. He claimed to have changed his own eye color from brown to grey using this strange X-Faculty and boasted about winning $600 off of a …
The Dual Ownership Structure: A Model To Connect The Cooperative Model With Financial Markets, Davis Seung Rok Nam
The Dual Ownership Structure: A Model To Connect The Cooperative Model With Financial Markets, Davis Seung Rok Nam
Honors Theses
In business literature, the conflicts among workers, shareholders and the management have been studied mostly in the frame of stakeholder theory. The stakeholder theory recognizes this issue as an agency problem, and tries to solve the problem by establishing a contractual relationship between the agent and principals. However, as Marcoux pointed out, the appropriateness of the contract as a medium to reduce the agency problem should be questioned. As an alternative, the cooperative model minimizes the agency costs by integrating the concept of workers, owners and management. Mondragon Corporation is a successful example of the cooperative model which grew into …
The Crystallization Kinetics Of Polylactic Acid (Pla) Processed Through Solid-State/Melt Extrusion, Brian Bernard Lynch
The Crystallization Kinetics Of Polylactic Acid (Pla) Processed Through Solid-State/Melt Extrusion, Brian Bernard Lynch
Honors Theses
Polylactic acid (PLA) is a bio-derived, biodegradable polymer with a number of similar mechanical properties to commodity plastics like polyethylene (PE) and polyethylene terephthalate (PETE). There has recently been a great interest in using PLA to replace these typical petroleum-derived polymers because of the developing trend to use more sustainable materials and technologies. However, PLA¿s inherent slow crystallization behavior is not compatible with prototypical polymer processing techniques such as molding and extrusion, and in turn inhibits its widespread use in industrial applications. In order to make PLA into a commercially-viable material, there is a need to process the material in …