Digital Commons Network^™

The Effects Of Marine Natural Products On The Microenvironment Of Pancreatic Cancer, Whitney D. Davis, Esther Guzman

Honors Theses

Pancreatic cancer is the 4th leading cause of cancer deaths in the United States, with that number increasing each year. New drugs need to be developed to treat this disease. One source of new drugs is marine natural products. Two compounds—HB-131 and HB-018—were tested for potential anti-cancer properties. Pancreatic cancer cells were exposed to these compounds for six hours and the conditioned media from this treatment was used to further our understanding of the effects of these compounds. A western blot was used to determine matrix metalloproteinase (MMP) expression, while a zymogram was used to determine MMP activity. A sandwich …

Analysis Of Change In The Biodiversity Of Fish And Macroinvertebrates Following Low Dam Modification And Kayak Chute Installation In The Great Miami River In Downtown Dayton, Ohio, Madison E. Conway

Honors Theses

Over two years, from 2015-2017, the Miami Conservancy District and Five Rivers Metroparks completed a project to modify the low dam above Monument Avenue into a kayak chute and constructed a second, entirely new kayak chute about one-half mile upstream near Riverscape Metropark in downtown Dayton, Ohio. Low dams have a negative impact on river habitat by decreasing water velocity in the impoundment behind the dam. Physical habitat, which should consist of alternating pools and riffles, is disturbed and replaced by deeper, slower-moving water that accumulates deposits of sediment on the river bottom degrading its value as habitat. The conditions …

Energy Analysis And Orbit Simulation Of Actuating Cubesat Solar Arrays, Justin T. Ehren

Honors Theses

CubeSats are used in space research to explore new technologies and detect data to gain a better understanding of various areas of research and subjects affecting human life. CubeSats rely on a solar array to generate energy from the sun and perform their various functions in space. This research studies the energy capturing potential of various solar array configurations and positioning devices for CubeSats. The location and orientation of a CubeSat is simulated with MATLAB for both geo-synchronous and sunsynchronous orbits. Two degree-of-freedom (DoF) positioning devices are sufficient to continuously adjust the photovoltaic array to face towards the sun. Lower …

Poverty Redemption: Why Those Affected Stay Affected, Claudia M. Hampel

Honors Theses

This paper looks at why those in poverty have not taken advantage of self-sufficiency programs that are offered through Miami Valley Works along with other self-sufficiency programs offered. This paper looks at the general reasons why those in poverty do not go through self-sufficiency programs, whether they chose not to participate or leave a program prior to completion. This paper delves into multiple factors that could contribute to why an individual would forgo to participate in the program or would choose to leave the program before completing it. The study examines how governmental policies, the culture of poverty, race, housing, …

Drosophila Tumor Mosaic Models To Study Intercellular Interaction, Minh T.D. Ho

Honors Theses

Drosophila is a powerful genetic model system to study cancer. In patients, a small number of mutations accumulate in cells that change their growth characteristics and eventually lead to the formation of tumors. These tumors are clonal in origin, meaning the cancer arose from the proliferation of a single rogue cell. We have developed similar "clonal" cancer models in the Drosophila brain to study how tumor cells interact among each other and with their neighbors. To study such interactions, we need to tag the tumor cells and their neighboring cells. Such differentially marked clone-pairs or ‘twin-spots’ are ideal for genetic …

Flourishing The Urban Environment: How Urban Gardens Affect Pollinators, Emily Ann Rickert

Honors Theses

The order of Hymenoptera is classified as bees, wasps, and ants and are widely recognized as pollinators. Some species of bees (family Apoidea) and hoverflies tend to focus on certain types of flowers and are attracted to patterns and colors. Native plants and crops that are specifically bee-friendly can encourage bees and other pollinators that are decreasing in biodiversity and population to come back. Urban gardens work to provide vegetables and organic produce to its communities and subsequently are also growing pollinator-friendly food. This study focuses on whether the biodiversity of Hymenoptera, hoverflies, and other significant pollinators are affected by …

Boron Dipyrromethenes: Synthesis And Computational Analysis, Eduardo Rivé Lockwood

Honors Theses

Recently, there has been a growing interest in the boron dipyrromethene (BODIPY, 4,4′- difluoro-4-bora-3a,4a-diaza-s-indacene) compounds. BODIPY compounds have fascinating properties that allow for the absorption and emission of light in the near infrared region of the electromagnetic spectrum. These molecules are highly modifiable making them ideal chemicals for the use of photoelectric energy conversion such as for commercial use in dye sensitized solar cells (DSSCs). It has been previously shown that different meso compounds have only a slight effect on the absorptive capabilities of these BODIPY compounds. We believe that the BODIPY compounds’ lack of planarity is one of the …

The Effect Of Remote Ischemic Preconditioning On Exercise Hyperemia In Multiple Sclerosis, Jane E. Rosmarin

Honors Theses

Remote ischemic preconditioning (RIPC) is a non-invasive technique in which blood flow is cut off to a limb for a short period of time which produces a protective effect throughout the whole body to subsequent low oxygen conditions. One of the prominent cardiovascular limitations to exercise in individuals with multiple sclerosis (MS) is fatigue, which may stem from the decreased delivery of oxygen to muscle tissue during exercise. The purpose of this study was to test the hypothesis that RIPC would increase forearm blood flow (FBF) and utilization of oxygen at the level of the muscle tissue in individuals with …

Leaving A Legacy: Empowering Students To Give Back, Eric Schutter

Honors Theses

Most college universities struggle to convince alumni to give back to their former institutions. Currently, only 19.9% of college alumni give back to their former colleges (Alumni Factor, 2018). Despite the amount of time and energy that schools invest in their students, many of the students are not making any sort of commitment in return. However, there is a solution. If college programs found ways to create avenues for students, both current and former, to give back outside of just university general funds, they could see an increase in student giving from both parties. While there is a notion that …

Disclosing Virtue, Michael Zahorec

Honors Theses

This project is about the shape of our moral understanding and discourse. Herein, I describe the moral discourse and understanding afforded through narrative. I understand narrative as both a medium of discourse (i.e. storytelling) and a mode of understanding (i.e. a way to understand oneself, others, and the world(s) in which we find ourselves). In order to describe the ethical understanding and discourse constructed through narrative, I use the meta-ethical framework of Aristotelian virtue theory. The language of virtue theory constitutes the framework upon which I construct my argument regarding the irreplaceable and efficacious nature of narrative. The preface tells …

Challenges Remain In Conducting Adequate Congressional Oversight, Alexander Crouch

Honors Theses

No abstract provided.

Stigma Mitigation Through Fine Arts, Kendall Owens

Honors Theses

Social stigma has plagued our society for centuries. It isolates groups of people based on erroneously defined characteristics causing stigmatized persons to be viewed as socially “abnormal”. This debarment from full social acceptance results in poor population health and well-being. Fine arts have been an integral component of society since the beginning of civilization; current and past research have found involvement in fine arts to improve health and well-being in many ways. In this project, relevant studies related to stigma, fine arts, and population health will be reviewed to support the argument that “fine arts combat and mitigate the …

Against The Young, Starry Background: A Critical Analysis Of A Creative Work In The Context Of Its Genres, Todd Kleiboer

Honors Theses

No abstract provided.

A Qualitative Study Of The Possible Link Between Masculinity And Aggression Among College Football Players, Leanna Brown

Honors Theses

No abstract provided.

Preparing College Graduates For Work Success In A Rapid Changing Modern-Day Business Landscape., Benito Vavra

Honors Theses

The goal of this thesis is to provide a well-developed and hypothetical course curriculum overview that could serve as a course for students in business school.

The course itself will contain three core phases:

1. Getting a job – How to get a job, more specifically covering the complexity in navigating through the process of attaining a job after college. Some of the topics will be getting hired, the interview process, job hunting, wage negotiation and its importance, setting up goals, and selecting a career path. (Readings: What Color is your Parachute)

2. Your Hired – Once a graduate is …

"Let Bartlet Be Bartlet:" The Presidential Politics Of Aaron Sorkin's The West Wing, Marjory Madeline Zuk

Honors Theses

From 1999-2006, Aaron Sorkin’s television show The West Wing entertained audiences with a weekly backstage pass to life in the White House. While the show featured plotlines regarding the characters’ personal lives, it also centered the policy decisions of President Bartlet and his staffers, and it informed audiences about political issues and tools. With background research, I confirmed that the style of the show was a valuable educational tool, as it used both episodic and thematic framing devices when discussing different political issues. My understanding of its ability to influence audiences’ understandings of political issues lead my interest in understanding …

Analyzing Access To Higher Education: Through The Lens Of Socioeconomic Factors At Bucknell University, Autumn J. Patterson

Honors Theses

Access to higher education in the United States greatly varies depending on numerous characteristics; especially an applicant’s race and financial status. This thesis aims to answer the following questions regarding access to higher education at Bucknell University: How have socioeconomic factors affecting access evolved in the past twelve years? Has this change increased or decreased access for Bucknell students? Does the level of access change when gender and race are analyzed? Is Bucknell successfully leveling the playing field for all students regarding their earning potential after they graduate? Lastly, does the mismatch hypothesis apply to Bucknell? By utilizing data from …

Structural Investigations Using Theoretical Approaches : A Study Of Metal Halides, Borylenes, Phenalenyl Complexes And Σ-Hole Interactions, Supreeth Prasad

Honors Theses

The anomalous bending in the group 2 binary dihalides and the absence of this behavior in group 12 systems is well established. Their structuralpreferences contradict simple bonding models, yet they have received little to no attention in the literature. In this work, for the first time, the gas phase structuralpreferences of the groups 2 and 12 mixed (ternary) dihalides MXY (M=Be, Mg, Ca, Sr, Ba, Ra, Zn, Cd and Hg,and X, Y=F, Cl, Br, I, At) are investigated at high levels of theory. I extend a previously established softness criterion for bending to the mixed systems and I find that …

A Comprehensive Analysis Of Financial Reporting Through Case Studies, Cole Conner

Honors Theses

This paper serves as an investigation and analysis of the financial reporting practices of publicly traded companies, in addition to addressing a number of other selected accounting topics. This was accomplished through the analysis of a number of accounting case studies. Each of these studies addresses a specific topic related to financial reporting such as the accounting for income taxes, the treatment of plant property and equipment, and the treatment of investments in securities. The cases provide background related to the topic and organization(s) discussed as well present a series of questions which guide in the discussion and analysis of …

Twelve Cases Of Accounting, Caroline Cantrell

Honors Theses

The honors accounting students at the University of Mississippi are given the option to participate in an alternative thesis track; we partake in a year-long class junior year in which we are given a case study every other week to complete by the following week. We are also required to participate in accounting case competitions sponsored by Big Four accounting firms, in which we give oral presentations of our business solutions to partners at the firms. In this thesis, I have investigated twelve case studies of accounting. The topics in these cases include generally accepted accounting principles, bad debt expense, …

Before Disaster Strikes: An Analysis Of Emergency Management Planning, Reagan Moody

Honors Theses

I have always been inspired by the outpouring number of volunteers that arrive to the scene of a natural disaster, ready to help in any way possible. With or without adequate training, these people arrive with warm hearts and helping hands. I admire their valiant efforts, however, it has prompted me to ask the question: If our citizens can respond so quickly in times of adversity, how are city governments preparing spontaneous volunteers for emergency management planning? The intent of this thesis is to properly evaluate the emergency management plans implemented in the cities of Baton Rouge, LA, Spokane, WA, …

Hit Me With Your Best Shot: A Critical Analysis Of The Resistance To Vaccine Utilization, Katherine Coleman Sistrunk

Honors Theses

Vaccines have provided humans protection from infectious diseases for centuries, yet the vaccination rate in the United States fails to come near one-hundred percent, allowing vaccine-preventable diseases to re-emerge in communities across the nation. Vaccines have proven to be a safe and effective method in preventing the spread of infectious disease, but vaccine resistance remains high due to false information perpetuated by anti-vaxxers, greatly impacting the vaccination rate in our country. This thesis, by means of a literature review, provides a critical analysis the resistance to vaccine utilization in the United States to determine what policy recommendations and interventions can …

Investigating The Response Criteria Shift Account For The Verbal Overshadowing Effect, Matthew C. Dean

Honors Theses

The present study investigated the impact of response criteria shift effects within the verbal overshadowing effect (VOE). Participants watched a video recording of a burglary and were then given one of two tasks: either 1.) a recall task or 2.) a non- recall task (Tetris). Participants were then shown a two-person lineup and forced to identify the burglar. The results of the experiment indicated that participants who engage in the recall task demonstrate verbal overshadowing, despite being forced to identify from a lineup. Essentially, verbal overshadowing occurs without a shift in response criteria.

Investigating The Binding Of Fentanyl And Fentanyl Analogs To The Μ-Opioid Receptor, Marissa Anne Teske

Honors Theses

In 1960, Dr. Paul Janssen of the Janssen Company synthesized fentanyl. It is a rapid-acting analgesic that, unlike similar analgesics around that time, did not have negative cardiovascular effects. Fentanyl, and its derivatives, are strong μ-opioid receptor agonists. Rates of fatal opioid overdoses involving fentanyl have increases rapidly over the past two decades Due to these increasing concerns related to fentanyl and its derivatives, it is important to not only study fentanyl and its known derivatives, but to also study and understand potential new derivatives and how all these compounds interact with the opioid receptors. This study examined the interactions …

Advanced Design And Manufacturing Of Composite High-Powered Rockets, Matthew Whitfield

Honors Theses

This thesis covers aspects related to the design and manufacturing of high-powered composite competition rockets. Research related to the project was performed over the course of three years of participation on the University of Mississippi Rocket Rebels competition team. Areas of the project covered include project definition, rocket design, and rocket manufacturing. Project definition covers how to build a team, select a competition, and establish communication, among others. The rocket design portion discusses the work that goes into meeting competition performance requirements, and includes simulations from the 2018-19 Rocket Rebels rocket. The rocket manufacturing portion includes a summary of manufacturing …

The Water Changed Me As A Person: How Childhood Experiences With Water Affect Behavior And Attitudes Towards Water As An Adult, Victoria Heim

Honors Theses

This research serves to identify how childhood experiences with water impact a person’s attitudes and behaviors towards water issues later in life. Current research looks at more one-dimensional studies, such as only attitudes and behaviors from childhood, or not exploring multiple variables such as gender and community type and childhood experiences. By interviewing two distinct groups of students in terms of typical environmental attitudes and behaviors expressed by members of each group or political party, the College Republicans and the Office of Sustainability, we can see how the individual respondents from each group may have had childhood experiences that shaped …

Time- And Ph- Dependent Proteolysis Of Engineered Proteins By Collagenase, Hunter Berry

Honors Theses

Pleiotropic effects from oral administration of anti-inflammatory drugs limit their effectiveness. The ultimate goal of this project is to develop a novel self-assembling protein-based hydrogel for in situ delivery of NSAIDs at the site of chronic inflammation. Since inflammation causes acidification and activation of collagenases in the inflamed tissue, we have designed the hydrogel to respond to both of these queues to effectively deliver drug at the site. Self-assembly of the protein hydrogel exploits the high affinity and specific interaction between the protein calmodulin (CaM) and its specific binding peptide, M13. The two components of the hydrogel, CCLP and PCLP …

Hydrogen Production By His Mutants Of Artificial Hydrogenase, Emory Elizabeth Wills

Honors Theses

Nickel enzymes are relatively new to be studied, but they have been found to be useful in creating artificial hydrogenases. Nickel alone can be harmful, but when combined with proteins to create an enzyme, the hope is that through catalysts, hydrogen can be produced for viable energy. The proteins used in the experiments had respective mutations at points 113 and 26. The cysteine at both of these points was replaced by a histidine to hopefully enhance metal binding. To create artificial hydrogenases and produce energy, the proteins were induced by various metals including nickel, copper, and cobalt. After experimentation and …

Expansion Of An Ultracold Neutral Plasma, Yin Li

Honors Theses

Ultracold neutral plasmas (UNP) exhibit interesting behavior and are more feasible to control than hot plasmas. Physicists would like to lower the temperature of a UNP to achieve a higher Coulomb coupling parameter, Γ for both electrons and ions. However, the three body recombination (TBR) between ions and electrons produces Rydberg atoms and heats up the plasma electrons, thereby ionizing them to Γe < 0.2. Adding Rydberg atoms to the plasma will reduce the temperature of a UNP in certain situations. In this honors project, we tried to achieve a Γe value greater than 0.5 by embedding Rydberg atoms multiple times in the plasma. We did extensive numerical simulations, but we were unable to replicate previous results from another group which obtained Γe = 0.5 in the first 1 µ s of plasma evolution. However, we were able to use the simulation results to test various different experiment scenarios. For experiments, we created a UNP of Rubidium atoms in the magneto-optical trap by laser cooling and photoionization. We figured out a nice way to zero the electric field within the field meshes by looking at the plasma expansion very late in its evolution through the micro-channel plate. We set the voltage and delay on the field mesh bias to find expansion velocity of the plasma for time t > 50 µs, and we used different methods to deduce the expansion velocity from the ion time of flight signals. However, we found that there was no relation of Γe at 1 µ s and the expansion velocity …

Game Theory In Cricket, Shabab Ahmed

Honors Theses

The paper uses the natural setting of cricket to test theoretical predictions in game theory. In this setting, the agents play a one-shot-two-person constant sum game. The paper assesses whether trained professionals in cricket follow the `mix' of strategies predicted by Nash equilibria. The test uses a unique dataset derived from commentary data comprising of bowler and batsman strategies and outcomes. The paper creates a model for bowler-bastman interactions in cricket and uses this in conjunction with the data to generate predicted Nash equilibrium frequencies. These predicted frequencies are then compared with the actual frequencies from the data. My study …