Digital Commons Network^™

Methods To Detect Forgeries In Static Signatures, Jennifer Lauriello

Honors Theses

Statistical and machine learning approaches to forgery detection in offline sig- natures are attempted and evaluated. Offline signatures are static signatures found on physical media, mainly a piece of paper. A dataset of 330 signatures for 33 people is used, containing five genuine and five forged signatures for each person. The statistical analysis approach proves more successful than a machine learning approach, likely due to the size of the dataset.

Approaches Towards The Synthesis Of Ketamine Metabolites, Ann K. Patrick

Honors Theses

Major Depressive disorder (MDD) plagues society and stands at the forefront of research as MDD affects approximately 16% of the population. Pharmaceutical drugs, including the selective serotonin reuptake inhibitors (SSRIs), have been used for MDD treatment and remain a popular option today. However, current antidepressant treatments have proven to be ineffective in just less than half of the patients. Research continues with the goal to better understand the mechanisms of the pathology of depression and to search for other treatment options. For example, the stress-neurogenesis hypothesis investigates the role of stress and decreased neuroplasticity within MDD.

Supporting the stress-neurogenesis hypothesis, …

Success And Failure Of Indigenous Social Movements: A Comparative Case Study Of Ecuador And Chile, Jenna White

Honors Theses

This thesis is a comparative case study of the social movements of the Mapuche in Chile and the fourteen indigenous tribes in Ecuador. I study their social movements by utilizing the structural strain theory of social movements. This theory states that people in society experience deprivation, the people recognize the deprivation, a solution is proposed and this ideology is diffused to the society, events occur to begin motion of the movement, the society (including government) need to be open to change, and eventually there will be mobilization of resources in order to form a successful social movement. The dependent variable …

Investigating The Link Between Executive Function And Creativity In School Aged Children, Katherine Crenshaw

Honors Theses

The primary purpose of this research was to examine links between executive function (i.e., EF or conscious control) and creativity in school aged children. To accomplish this, participants completed measurements of creativity (i.e., Alternative Uses) and EF (i.e., the Backwards Digit Span to test working memory, the Delay of Gratification task to test inhibition). I also examined whether a creative manipulation (i.e., free coloring or coloring task-relevant materials) would impact EF performance in the Dimensional Card Change Sort (DCCS) focused on cognitive flexibility. While I did not find evidence for a relationship between my measures of EF and creativity, I …

Unplanned Pregnancy In The Mississippi Delta: Causes And Implications, Julia Grant

Honors Theses

This study seeks to understand the causes and implications of the abundance of adolescent pregnancy in the region known as the Mississippi Delta, where teenage childbearing is among the highest in the nation. To do so, this study reports and analyzes twelve interviews with young, African American, single mothers conducted by the author in the summer of 2019. This study relies on a narrative approach to research and analysis and employs the theoretical framework of Afrocentrism. As a result of the interviews, the author concludes that a blatant lack of sex education in the region is a powerful influence on …

The Relationship Between Glucocorticoids And The Humoral Immune Response To Mycoplasma Gallisepticum Challenges In Eastern Bluebirds, Joshua Smith

Honors Theses

Numerous studies have examined relationships between adrenal glucocorticoids and the immune system’s ability to fight disease. The relationship can vary, with glucocorticoids having either stimulatory or inhibitory effects. The pathogenic bacterium Mycoplasma gallisepticum (MG) elicits an adaptive immune response in birds, in which B cells produce MG-specific antibodies to fight the infection and prevent reoccurrence. Previous research found that Eastern Bluebirds that produce the most antibodies in response to MG infection also have the highest glucocorticoid levels. This finding led to the current study investigating whether corticosterone, the primary glucocorticoid in birds, stimulates production of antibodies in response to immune …

An Investigation Of The Practical Challenges To Using Molecular Genetic Techniques To Identify The Parasite Burdens Of Vertebrate Animals From Non-Invasive Sampling, Keely Ann Cox

Honors Theses

Molecular genetic techniques have become popular methods in ecology and wildlife conservation research. Advances in molecular genetic methods, particularly PCR (polymerase chain reaction), make it possible to amplify the numbers of specific DNA sequences from a sample with only a few original copies. Theoretically, the specificity of this approach should make it possible for wildlife biologists to identify and quantify the parasite and disease burden of endangered animals without being limited by the rarity of collaborators with expertise in the taxonomy of obscure parasite taxa. Because PCR requires just a small amount of DNA, the added benefit of a molecular …

The Embark® Protocol: Dog Genomics In Genetics Laboratories, Alexandra Kissel

Honors Theses

In a world of ever-advancing technology, it is imperative that young pre-health professionals are educated according to the most relevant research. One of the most fundamental, foundational concepts of health is genetics. This field is rapidly expanding, and quickly engraining itself into the realm of healthcare. Genetic testing and gene therapies, once subjects of science fiction, have become commonplace. It is more important than ever that health professionals have a concrete knowledge of genetics, and this begins with the proper education of pre-health students.

With this idea in mind, a laboratory protocol was designed for students of the Bisc 336 …

Regulating Neuronal Growth With Structurally Defined Glycans, Gabriella D. Hartman

Honors Theses

Chondroitin sulfate proteoglycans (CSPGs) and keratan sulfate proteoglycans (KSPGs) play an important role in neural development. Aggrecan, a CSPG, operates in the neural extracellular matrix where it negatively regulates neurite outgrowth to prevent aberrant process formation. Unfortunately, this aggrecan or CSPG-rich/KSPG-rich barrier can also prevent neuronal regeneration, which contributes to the inability to repair brain and spinal cord injuries. Removal of CSPGs and KSPGs has been shown to increase neurite outgrowth. We extend these findings by testing the ability of structurally-defined glycans to outcompete aggrecan and allow neurite outgrowth. Our overall goal is to determine if there is a particular …

Beat The Church Crowd, Evelyn Alston Tyer

Honors Theses

Beat the Church Crowd is a collection of poems that explores a variety of topics and themes, from personal family legacy and natural disasters to bestiary, ekphrastic, and southern locale poems. It is divided into four sections: “Blue Danube,” “Anecdotes,” “Urban Legends,” and “Something Worth Protecting.” While the subject matter and forms of the poems vary, the common thread weaving each poem to the next is the slight touch of the macabre.

Little Girl In The Country: A Children's Book, Holly Mcginnis

Honors Theses

A Work of Children’s Literature to Address Realities of Childhood in the Southern United States

This thesis investigated the intersection of life’s realities and children’s literature. Representation is an oft-talked-about area of children’s literature. It is coming to light that many groups are underrepresented in writings for children, and recent works are attempting to broaden the types and backgrounds of characters to represent the diversity of readers and authors. This thesis is the author’s attempt to accurately represent the types of students she encountered in student teaching experiences in the Oxford-area. Using inspiration from her own childhood and knowledge of …

Lead In Drinking Water And The Effectiveness Of Point-Of-Use Filtration, Donald Hopper

Honors Theses

Lead in drinking water has been proven harmful to human health and is an ongoing problem in the state of Mississippi. The goal of this thesis is to analyze lead contamination data in Mississippi, its implications, and possible short-term solutions for remediation. This was done through community outreach events and voluntary sampling in the Jackson, MS area, analyzing published data from the Mississippi State Department of Health, and conducting controlled sampling and testing in Lafayette County, MS.

Community engagement events were executed in which researchers informed citizens in the Jackson, MS area about the impacts of lead in drinking water …

More Than A Language: A Detailed Look At The English Major, Hannah Woods

Honors Theses

This thesis analyzes the perceptions of the English Major in order to come up with suggestions for the Univeristy of Mississippi English Department with the purpose of increasing enrollment in the English Program. The last decade has seen a large decrease in the number of English Majors throughout the country, and this decrease has been reflected in the University of Mississippi. This thesis looks at recent opinions of the English Major in society, including popular criticisms of the major and responces from the English community. It was found that the two main criticisms of the English Major are that graduates …

The Effects Of Insulin-Like Growth Factor-1 (Igf-1) And Insulin-Like Growth Factor Receptor (Igfr) Regulation On Cognition And Structure Of Astrocytes, Sariya Khan

Honors Theses

Insulin-like growth factor-1 (IGF-1) is a neuroendocrine signaling hormone that plays an integral role in bone and tissue growth and development. Inhibition of this hormone is known to disrupt the chemistry of the brain, resulting in cognitive impairments such as those seen in many common neurodegenerative diseases. While much research has been conducted on neurons and their relation with IGF-1, the role of astrocytes still needs to be explored. Our research investigates how astrocytes are affected as a result of IGF-1 regulation. Preliminary studies in our laboratory established a connection between IGF-1 and glial fibrillary acidic protein (GFAP), and in …

Electronic Health Records And Health Information Exchange And Their Impact On International Healthcare System Efficiency, David Pfaehler

Honors Theses

The 19th century epidemiological transition in healthcare caused a major shift in physician focus from curing one-time, deadly illness to managing chronic disease. Now, even the most advanced international healthcare systems must find a way to increase their efficiency in order to compensate for heightened strains on medical systems and swelling costs of healthcare delivery. Fortunately, recent technological innovation and, chiefly, the growth of Electronic Health Records (EHRs) provide a potential solution to this looming threat. EHRs are digital charts with the potential to store and share patient health data among providers to offer the most informed, streamlined care available. …

Facebook: A Contemporary Analysis Of The Influential Global Power Of Facebook And How It Affects Our Society (And Recommendations On How To Fix It), Jayde Taylor

Honors Theses

This thesis analyzes the global influence of the major social media platform Facebook, in real time. The text reviews Facebook’s guidelines and regulations and provides examples of significant social influence. It also analyzes possible solutions, why these solutions provide barriers, and recommendations for current Facebook users.

This information was collected by the individual during months of research. It started with a broader focus on the spread of false information and media literacy. After getting an in-depth understanding, it was decided to focus more specifically on Facebook. All information was collected from scholarly journals, news articles, books, and Facebook. The research …

A Nonanthropocentric Response To The Cosmic Perspective Problem, Eveanne Eason

Honors Theses

This paper responds to issues that have been raised for environmental philosophy in light of developments in astrobiology and exoplanet science. In recent years, we have moved much closer to confronting evidence of life beyond Earth. Pairing such a discovery with a certain theoretical understanding of the universe, we might be motivated to address a question: with knowledge of abundant, potentially infinite alien life on Earth-like planets, why must we save our planet? In anticipation of this discovery, we can use this scenario, the Cosmic Perspective Problem, to refine a widely-held position with substantial implications for our environmental ethics. The …

Studies Of Salvinorin-Based Antagonists To Elucidate Pertinent Interactions For Kappa Opioid Receptor Antagonism, Madeline Keane

Honors Theses

Opioid abuse, leading to addiction and related deaths, has created a chronic epidemic in the United States for the past 30 years. This crisis has sprung from reliance on the prescription of opioid analgesics as the primary method for the management of pain in the 1990s. At that time, these drugs, specifically Purdue Pharma’s OxyContin, were marketed as non-addictive. Due to this systemic minimization of the addictive properties of opioid analgesics, as prescription rates increased, opioid-related mortality rates climbed. This epidemic continues to be pervasive, as opioid-related overdose resulted in 47,600 deaths in 2017. In addition to the opioid epidemic, …

Elucidating The Functional Location Of Platelet-Derived Growth Factor Receptor Alpha, Creation Of A Review Chapter On The Use Of Zebrafish In Studying Congenital Heart Defects, And Using 3d Printing To Create Laboratory Tools, Jaret Lieberth

Honors Theses

Congenital heart defects (CHDs) are currently the most prevalent form of birth defect in the United States. Their combined frequency and severity make necessary a deeper understanding of the molecular underpinnings guiding heart formation. The first major step in cardiac morphogenesis, cardiac fusion, involves the medial movement of bilateral populations of myocardial precursor cells to the embryonic midline, where they merge to form the primitive heart tube. Although crucial to subsequent organogenesis, the precise mechanisms governing cardiac fusion remain unknown. Previous studies have found that a mutation in platelet-derived growth factor receptor alpha (pdgfra), called refuse-to-fuse (ref), results …

A Raman Spectroscopic And Quantum Chemical Investigation Of Serotonin, It's Intramolecular Interactions, And The Solvent Effects Of Methanol, Ethanol, And Water, Mallory Loe

Honors Theses

Serotonin, or 5-hydroxytryptamine, is a neurotransmitter and metabolite vital to the normal function of the cardiovascular, gastrointestinal, and nervous systems. Although it might be colloquially known as the ‘happiness drug,’ malfunctions in serotoninergic pathways can result in mental health disorders, heart disease, irritable bowel syndrome, and even collateral death. Without a current method to directly measure, or even detect, serotonin in the human body, these diseases, along with many others, pose a threat of developing without proper warning. Raman spectroscopy presents a unique method to vibrationally characterize molecules based upon the inelastic scattering of light. Serotonin’s unique, amphipathic structure presents …

Ectomycorrhizal Fungi And Effects Of Soil Microbes Associated With Slash Pine Encroachment Into Native Longleaf Pine Habitat, Madison Brooke Woodruff

Honors Theses

Biological invasions can cause substantial changes to the environment: indigenous species can be reduced or even eliminated, soil characteristics shifted, and nutrient cycles altered. Ectomycorrhizal (ECM) fungi are thought to be key biological controllers of some plant invasions, especially benefiting Pinus species in invasions at exotic sites, but less is understood about the role of ECM fungi and other soil microbes in encroachment by one plant species into the habitat of another in their native ranges. In this study, soil was collected from three habitats in southern Mississippi, USA: native slash pine maritime forest, longleaf pine savanna encroached by slash …

Impacts Of Embryonic Exposure To Cannabidiol Or ∆9-Tetrahydrocannabinol On Zebrafish (Danio Rerio) Frailty In F0 And F1 Generations, Anika Faruque

Honors Theses

Exposure to cannabinoids during critical development periods has increased with epileptic children being commonly prescribed CBD for seizures and pregnant women taking it recreationally. Many studies have been done on the possible benefits and drawbacks of cannabinoid exposure on the human brain, but not much is known about how it can affect the developing brain long-term. To see the potential adverse effects of cannabinoid exposure during critical stages of development and discover potential developmental origins of disease in consuming cannabinoids during embryogenesis, zebrafish embryos (6-96 hours post fertilization) were exposed to varying concentrations of CBD (0.02, 0.1, 0.5 µM), THC …

Exploring The Role Of Ccdc141 In Zebrafish Heart Development, Luci Strong

Honors Theses

Zebrafish are a good model organism in which to identify genes important for heart development because most human genes have a zebrafish ortholog and genes in zebrafish are relatively simple to modify. ccdc141 is a gene with unknown function, which we originally found to be highly expressed in cardiac cells in mouse embryos. In this project, we are seeking to determine the function of ccdc141 using zebrafish. To perform this experiment, we are targeting ccdc141 for mutation using CRISPR/Cas9. In this project we have analyzed ccdc141 to determine regions of conservation, designed CRISPR guides to target those regions (exon 2 …

The Life And Struggles Of Red Cockaded Woodpeckers, Michaela Gay

Honors Theses

This series of paintings focuses on red cockaded woodpeckers, an endangered species of bird and the longleaf pines forests which they live in and are reliant upon. I drew my inspiration mostly from personal experience with my family’s own efforts to restore one of these forests as well as my longstanding belief in the importance of protecting the environment. However, the point of these paintings is not to preach to people, but rather to show them the beauty of these trees and birds, so they can perhaps begin to care about them themselves instead of just being told that they …

Effects Of Repeated Intermittent Episodes Of Social Stress On The Acquisition And Extinction Of A Reward-Seeking Task, Nikki Sullivan

Honors Theses

Repeated exposure to stress is known to have a myriad of effects on the brain, contributing to the development of psychiatric disorders, such as anxiety, depression, and drug addiction. For example, rats undergoing repeated social stress develop increased cocaine self-administration. These effects of stress are not well-understood and are related to changes in the brain reward system. This study investigated the effects of repeated social stress on reward-seeking behavior via the acquisition and extinction of a discriminative stimulus (DS) task and on anxiety-like behavior in the elevated plus maze (EPM). Male rats underwent intermittent social defeat (4 sessions in 10 …

The Impact Of Age/Rage Signaling On Oxidative Stress Under Diabetic Conditions In Cardiac Fibroblasts, Christopher Dorroh

Honors Theses

Diabetes is a major health concern in the United States, with 1.5 million new cases diagnosed each year. Patients who suffer from diabetes have an increased risk of developing heart failure, a form of cardiovascular disease. Heart failure has been shown to result from increased left ventricular stiffness, which in turn is caused by increased remodeling of the extracellular matrix (ECM). This increase in ECM remodeling is a result of AGE/RAGE signaling, which occurs at a heightened level in the cardiac fibroblast cells of diabetics. Studies have shown that diabetics have elevated levels of AGEs (Advanced Glycation End-Products), which bind …

The Marduk Archives: A Take On Thresholds, Christopher Melton

Honors Theses

A fictional screenplay exploring the relationship between absurdity and convention as it pertains to the shifting cultural paradigms of our society. (Under the direction of Beth Spencer)

Implementation Of A Computer-Vision System As A Supportive Diagnostic Tool For Parkinson’S Disease, Diego Machado Reyes

Honors Theses

Parkinson’s disease is the second most common neurodegenerative disorder, affecting nearly 1 million people in the US and it is predicted that the number will keep increasing. Parkinson’s disease is difficult to diagnose due to its similarity with other diseases that share the parkinsonian symptoms and the subjectivity of its assessment, thus increasing the probabilities of misdiagnosis. Therefore, it is relevant to develop diagnostic tools that are quantitatively based and monitoring tools to improve the patient’s quality of life. Computer-based assessment systems have shown to be successful in this field through diverse approaches that can be classified into two main …

Etruscan Biophilia Viewed Through Magical Amber, Greta Rose Koshenina

Honors Theses

In this thesis, I explore the usage and purpose of amber objects in burials from Etruria, specifically from the late Villanovan Period (ca. 800-720 BCE) to the Orientalizing Period (ca. 720-580 BCE). I have followed a combination of quantitative and qualitative research approaches as well as visual analysis of amber grave goods. While there has been extensive research on the medicinal and ritual purposes of amber grave goods from excavated Etruscan tombs, I show that there was likely a specific interest in amber that contains organic inclusions likely because of the Etruscans’ interest in nature. I examine the presence and …

Receptive And Expressive Prosodic Abilities In Adults With Down Syndrome, Logan A. Kingry

Honors Theses

Individuals with Down syndrome, a population that often struggles with communication, present a unique linguistic profile of strengths and weaknesses. Almost no research has examined prosody in adults with DS, despite the important role it plays in effective communication. The present study investigated the prosodic profile of seven adults with Down syndrome (18;07-34;11 years) using the Profiling Elements of Prosody for Speech and Communication (PEPS-C), and compared the group’s expressive and receptive prosodic abilities to a group of seven adults with mixed-etiology intellectual and developmental disability (29;02-37;07 years) matched on nonverbal ability. Data analyses showed that the group with Down …