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Mechanisms Of Neuroprotection Against Retinal Ganglion Cell Loss Using An In Vivo Glaucoma Model, Kevin Heinze

Honors Theses

Glaucoma is an incurable ocular disease characterized by apoptotic cell death and degeneration of retinal ganglion cells (RGCs), and is one of the leading causes of blindness worldwide (Quigley and Broman, 2006; Quigley et al., 1995). While current treatments are effective at slowing vision loss, glaucoma’s multifactorial etiology has made it difficult for researchers to identify a target for treatment that will permanently halt RGC degeneration. Previous studies have proposed a glutamate-induced excitotoxic mechanism of RGC death in glaucoma, and neuroprotective agents have been investigated to prevent this effect. One agent, acetylcholine, has been shown to initiate pro-survival signaling cascades …

"Effects Of A Specific Acetylcholine Receptor Agonist In A Rat Glaucoma Model", Maha Alfaidi

Honors Theses

PURPOSE: This study was designed to investigate the neuroprotective effects of a specific nicotinic ACh agonist, PNU-282987, on the loss of retinal ganglion cells (RGCs) in a rat glaucoma model. A time-dependent study using 2 mM PNU-282987 was performed to determine the neuroprotective effect in the vertebrate retina.

METHODS: Hypertonic saline solution (2M NaCl) was injected into the episcleral vein of the rat’s eye to reduce the numbers of RGCs and mimic the effect of glaucoma. In one set of studies, PNU-282987 was applied to the right eye of each experimental animal as eye drops in combination with the NaCl …

Transgender Representation In The Media, Jessica N. Jobe

Honors Theses

The media is pervasive in American society – more people have television sets than college degrees. For this reason, media is crucial in the spread of information. The way groups of people are represented in the media can be both reflective of and influential on society's (possibly stereotypical) perceptions of these groups. The transgender community often gets misrepresented in the media. As a whole, the transgender community faces a lot of prejudice in American society, and current transgender representation in the media has the power to reinforce negative stereotypes. Twelve examples of news, television, and movies from as early as …

The Separate And Combined Effects Of Heredity And Environment Predicting Alcohol Use Disorder Symptoms And Antisocial Personality Disorder Symptoms, Jaylee R. Gill

Honors Theses

The current study examined genetic and environmental influences in relation to alcohol use pathology. The 756 participants (378 adoptive, 378 non-adoptive) came from the 2001-2002 NESARC conducted by the NIAAA. A factorial ANOVA was used to measure the effects that the three grouping variables had on each dependent variable for a total of seven datasets. Results showed that biological parents’ drinking did pose a risk in participants for Loss of Control (p = .000) and Dangerous Behavior (p = .00). Adoption status was correlated with Conduct Disorder (p = .007) and Antisocial Personality Disorder (p = .014). This suggests that …

Developmental Expression Profile Of Bric Á Brac 2, Midline And H15 In The Developing Eye And Central Nervous System Of Drosophila Melanogaster, Petra Visic

Honors Theses

Aberrant activity of a single gene can lead towards development of cancerous cells. Drosophila melanogaster is a useful model system to study cancer because there is high degree of evolutionary conservation in signaling pathways between humans and flies that play major roles in regulating cell proliferation and growth (Miles et al., 2011). At The University of Southern Mississippi (USM), Dr. Leal’s lab has gathered evidence suggesting that bab1 and bab2 interact with the T-box gene midline (mid) and its paralog H15, while the early developmental function of bab1 and bab2 remains unknown. That is why elucidating the early …

Abuse Of Spice, Bath Salts, And Steroids, Rebecca Coburn

Honors Theses

The abuse of three different drugs and whether or not they should continue to be banned in the United States is looked at. These three drugs are spice, bath salts, and steroids. In conclusion, spice and bath salts should continue to be banned in the United States due to the little knowledge known on the drugs and how they affect the body. Steroids on the other hand should only be banned in the use of sports, due to the unfair advantage that it gives users. For individuals not in sports, steroids should be legal since it is their choice to …

The Magic Of Books: A History Of Medieval Magic And Literature, Ana Maria Lavado

Honors Theses

Narrative binds people together with a common language and experience. It provides a singular manner for communication and interaction. Without this interaction, there would be no society or culture to speak of; with no way to articulate and control sounds, humans would be forced to communicate through the use of motions and gestures, deprived of the beauty and magic of language. Words can somehow capture pain, joy, beauty, awe, sadness, excitement, emotion and the very thrill that comes from being alive in a way that nothing else can. Language can inspire and influence as much as it can inflict pain …

A Case Study Of Polycystic Ovarian Syndrome, Rebecca Lynch

Honors Theses

Polycystic Ovarian Syndrome (PCOS) is a physiological disorder that causes many negative effects involving a variety of systems in the body, such as the endocrine, metabolic, psychological, and reproductive systems. This paper will explore the complex mechanisms behind the manifestation of PCOS and how these, and other factors, may make diagnosis difficult. In order to thoroughly understand these aspects of PCOS, the causes, symptoms, and treatments were explored. The diversity of causes and symptoms of the disease add to the difficulty in diagnosis and treatment of PCOS. The best treatment option varies among individuals, and the effectiveness of each treatment …

The Effects Of Testosterone On Leydig Cell Development In Male Yhr+ Mice, Steven D. Ebers

Honors Theses

Leydig cells (LC) are specialized cells in the testis that develop during puberty and are responsible for producing testosterone. Luteinizing Hormone (LH) and testosterone are important for LC development. Binding of LH to its receptor (LHR) initiates the production of testosterone. Constitutively active mutations in LHR have been identified in humans resulting in puberty in males as young as 3 or 4 years of age. A transgenic mouse (YHR⁺), was generated which mimics the constitutively active LHR by fusing the hormone, human chorionic gonadotropin, to LHR to continually activate the receptor. Testosterone levels in YHR⁺ mice are …

Women And The Epistemologies Of Pleasure: An Analysis Of Female Sexual Appetites And Practices At Bucknell University, Heather Wakeman

Honors Theses

Using an epistemological and feminist lens, this thesis analyzes the political and social forces that actively construct both knowledge and ignorance around female sexual pleasure. It draws from interviews and a focus group, all conducted at Bucknell Unviersity to explore the journeys that women take to gain knowledge about sexual pleasure, and how the sources and cultural mores that women in the twenty-first century rely on or go up against in order to gain such knowledge are often limited, unauthorized or phallocentric. This aids in the construction and perpetuation of ignorance. This thesis looks at how women feel shame or …

Chinese Whiteness: The Discourse Of Race In Modern And Contemporary Chinese Culture, Kirstin Clouser

Honors Theses

This thesis chronicles the development of western forms of race and racism in China. It then studies contemporary China using theories derived from whiteness studies in order to explain the unique position that whites (Caucasians) have in China today. In Chapter I, I break down the definition of race and introduce a foundation for a whiteness studies approach to research. In Chapter II, I analyze how Chinese classified themselves and other humans prior to the western system of race. In Chapter III, I chronicle the introduction of western forms of race and racism to China, and the appropriation of these …

Dads, Daughters, And Disney: The Historical Trajectory Of Fairy Tale Fathers And Daughters, Katie Mancino

Honors Theses

In my thesis I use a historical approach to close readings of fairy tale texts and movies to study the evolution of fathers, daughters, and marriage within three landmark tales: ¿Cinderella,¿ ¿Sleeping Beauty,¿ and ¿Snow White.¿ Using the works of Giambattista Basile, Charles Perrault, Jacob and Wilhelm Grimm, and Walt Disney and his cohort of animators, I trace the historical trajectory of these three elements, analyzing both the ways they change and develop as history progresses as well as the ways they remain consistent. Through close and comparative readings of primary sources and films, I demonstrate the power structures and …

Plato's Doctrine Of Forms: Modern Misunderstandings, Chris Renaud

Honors Theses

Among the philosophical ideas of Plato, perhaps the most famous is his doctrine of forms. This doctrine has faced harsh criticism due, in large part, to the interpretations of this position by modern philosophers such as René Descartes, John Locke, and Immanuel Kant. For example, Plato has been interpreted as presenting a ¿two-worlds¿ approach to form and thing and as advancing a rationalist approach to epistemology. His forms have often been interpreted as ideas and as perfect copies of the things of the visible world. In this thesis, I argue that these, along with other interpretations of Plato presented by …

A Social Network Analysis Of Hamadryas Baboons, Christian Treat

Honors Theses

The study of animal sociality investigates the immediate and long-term consequences that a social structure has on its group members. Typically, social behavior is observed from interactions between two individuals at the dyadic level. However, a new framework for studying social behavior has emerged that allows the researcher to assess social complexity at multiple scales. Social Network Analysis has been recently applied in the field of ethology, and this novel tool enables an approach of focusing on social behavior in context of the global network rather than limited to dyadic interactions. This new technique was applied to a group of …

A Study Of The Niche Structure And Habitat Utilization Of Urban Dwelling Winter Birds, Thomas Huff

Honors Theses

A study was conducted to evaluate the distribution of urban birds relative to differences in habitat as determined by zoning type. A total of 1,948 individual birds and a total of 33 species were sampled across the four different zones (industrial, commercial, residential, and public use.) The industrial use zone contained the highest number of individuals whereas commercial zones contained the fewest. However, the four zones contained approximately equal species richness.

Industrial zones supported the greatest number of cavity nesting and seed eating species. Residential and public use zones contained greater numbers of insectivorous and cup nesting species. In the …

Culture Flock, Rachael M. Huszar

Honors Theses

Details of the research, planning, and execution behind the exhibit "Culture Flock" which opened in the University Museum on April 2nd, 2013, and ran through May 10th, 2013. Final text panels and images of the exhibit in progress are included.

The Portraiture Of Women During The Italian Renaissance, Rachel D. Masters

Honors Theses

From research, it is clear that gender is one of the greatest influences on Italian Renaissance portraiture. Gender affects multiple aspects of portraiture including its function, position of sitter, emphasis of costume, and the degree to which a sitter is idealized. Until recent years, art historians performed little research on the subject of women as seen in Italian Renaissance paintings. In the 1970s, scholars began to assess the representation of women from this time period using Renaissance treatises, recorded debates, and paintings.

This study of the portraiture of women during the Italian Renaissance seeks to interpret the function of portraiture, …

An Examination Of The Social Functions Of Mouth Behaviors In Bottlenose Dolphins (Tursiops Truncatus), Kirsten E. Lapuyade

Honors Theses

This project examines the social functions of mouthing behaviors in bottlenose dolphins (Tursiops truncatus). The Roatan Institute for Marine Sciences (RIMS) houses dolphins which are captive but in a natural habitat. The twenty-six dolphins are used in human interactions, but for the rest of their time they are allowed to roam naturally. These dolphins make it possible to examine natural social behavior in a captive setting. The following study examines video data of these dolphins obtained by Dr. Stan Kuczaj in 2009. Behavior of the dolphins in these videos was recorded, the primary focus being mouthing behaviors.

There …

What’S Love Got To Do With It? A Content Analysis Of English And Spanish Idiomatic Expressions, Allie R. Solomon

Honors Theses

Idiomatic expressions are figurative in nature and vary from language to language, offering valuable insight toward understanding cultural connotations concerning the topics expressed. This study focused on idiomatic expressions that contain the word “love” or its grammatical variants found in the English and Spanish languages. The aim of this study was to conduct a qualitative analysis of these idiomatic expressions in order to identify cultural connotations, insight, and patterns regarding the communication of love within these expressions. A sample population of these expressions was obtained from a collection of available idiom and phrasal dictionaries and books written in English and …

Popularity Of Virtual Reality Immersion In Theme Park Attractions Of North America, Jessica A. Jelinski

Honors Theses

Theme parks continually change to incorporate new technology. Since the development of virtual reality, designers of theme park attractions have utilized several different immersion technology systems. Most of the current attractions are based on the Head-Mounted Display system and the Cave Automatic Virtual Environment system. To date, few studies or papers have been published concerning the effect virtual reality and the accompanying immersion technology may have on theme park attractions. One hundred and seventy-eight attractions from eight theme parks were categorized based on level of immersion and then analyzed for this study. Wait times for these attractions were used to …

The Trap-Neuter-Return Program As A Means For Collecting, Analyzing, And Comparing Data In Animal Care Facilities In Florida, Louisiana, And Mississippi, Stephanie T. Doty

Honors Theses

The TNR program has been met with both scrutiny and approval as a result of conflicting data from studies that examine its usefulness as a means of controlling the free-roaming cat population explosion (Levy & Crawford, 2004). Though the differing opinions will be discussed, it is not the intention of this paper to provide evidence in support of one or the other; instead, the purpose is to examine the various clinics’ implementation of the TNR program and its usefulness in providing data. In addition, an analysis of the data was done to determine what they may suggest about the free-roaming …

Effectiveness Of Individualizing Interventions Informed By The Hierarchic Dementia Scale (Hds), Used By Nursing Staff, To Reduce Aggressive Behaviors In An Individual With Alzheimer’S Disease, Nicki E. Relan

Honors Theses

Alzheimer’s disease (AD) is the most common form of dementia, representing 60 percent of all cases, and is described as a chronic, progressive, degenerative cognitive disorder. With loss of independence due to cognitive impairment, AD patients become more confused and anxious, which leads to a higher incidence of aggression towards nursing staff. It is paramount that the nursing community seeks new evidence-based healthcare innovations to reduce aggression and to protect caregivers. The aim of this study was to determine the effectiveness of individualizing interventions informed by the Hierarchic Dementia Scale (HDS) to reduce aggressive behaviors in people with Alzheimer’s disease. …

Water Simulation On Webgl And Three.Js, Kerim J. Pereira

Honors Theses

Technology is constantly moving forward. Computers are getting better and better every single day. Processors, memory, hard drives, and video cards are getting more powerful and more accessible to the users. With all of this hardware progressing, it is also logical that users want software to evolve as fast as the hardware.

Since this new hardware is available to the user, the easiest way to make graphics even more accessible to everyone is through the web browser. This move to the browser simplifies the life of the end user so that he does not have to install any additional software. …

Plasmodium Prevalence In Northern Cardinals Over An Eight Month Period, Kaylee M. Gentry

Honors Theses

This study implemented microscopic assays on field collected data to assess the prevalence of avian malaria in a non-migratory species, Cardinalis cardinalis. Following capture, blood smears were collected from birds at the University of Southern Mississippi’s Lake Thoreau Environmental Education and Research Center over an eight month period from September 2012 to March 2013. These smears were then stained using a Hema 3 stain set and microscopically assessed for the presence of Plasmodium relictum (avian malaria). Stained blood smear samples from a migrant species, Junco hyemalis, were used for comparisons of malarial infection. Additionally, corticosterone (CORT) assays were …

Drosophila T-Box Transcription Factor Midline Functions In The Notch-Delta Signaling Pathway To Regulate Sensory Organ Precursor Cell Fate And Cell Survival And Embryonic Development Profile Of Midline, Senseless, And Achaete In The Cns And Pns, Joseph D. Saucier

Honors Theses

The gene mid of Drosophila is a highly conserved gene that codes for a T-box transcription factor with similar functionality to its vertebrate homolog Tbx20. Mid and Tbx20 are important for their roles in heart and CNS development. Additionally, these transcription factors aid in proper eye development but this area of research is vastly understudied. This study uses the eye of Drosophila to report that mid and its paralog H15 expression aid in the specification of sensory organ precursor (SOP) cell fates and cell survival in the pupal eye imaginal disc. Using RNAi interference to reduce mid expression resulted in …

Changing The Nature Of The Beast: An Analysis Of Significant Variations From Madame De Beaumont’S La Belle Et La Bête In Disney’S Beauty And The Beast, Heather A. Stevens

Honors Theses

Madame Jeanne-Marie LePrince de Beaumont wrote and published La Belle et La Bête while working as a governess and educator in 1757. She told the tale to a young female audience as a means of teaching important life lessons. Walt Disney’s animated film Beauty and the Beast, released in 1991, is clearly inspired by Beaumont’s story, yet Disney makes many alterations to her characters. This thesis locates and analyzes these changes, arguing that they greatly alter the message of Beaumont’s story from one that is empowering to women to one that is harmful and ultimately anti-woman. This thesis also examines …

Characterization Of The Function Of A Mold Specific Gene, Ms95, In The Pathogenic Dimorphic Fungus, Histoplasma Capsulatum, Danielle J. Williamson

Honors Theses

Histoplasma capsulatum is a dimorphic fungus that causes the respiratory disease histoplasmosis. At 25°C, the fungus grows as a multicellular mold in soils contaminated by bird and bat excreta. Once the soil is disturbed, spores are released and inhaled into the lungs. The fungus shifts to a unicellular, pathogenic yeast within the lungs at 37°C. Our laboratory’s main objective is to characterize the genes that are involved in the mold-to-yeast dimorphism. This study focuses on the mold-specific gene, MS95. According to The Broad Institute Histoplasma capsulatum GenBank Blastx search, MS95 has several homologs, including the well-studied Saccharomyces cerevisiae. …

Identification Of An Unknown Intracellular Organism In Karenia Brevis, Daniel O. Mcarthur

Honors Theses

The dinoflagellate K. brevis is a mixotrophic marine alga that is of ecological importance in coastal waters especially along the Gulf of Mexico. They are one of a few species of algae responsible for the production of “harmful algae blooms” or HABs in which they release neurotoxins called brevetoxins which negatively impact fishing industries, local wildlife, tourism, and coastal health. Because of the danger these algae pose their lifecycle and characteristics merit intensive study.

During a previous experiment in Dr. McLean’s lab involving salinity stressing cultured K. brevis, the stressed cultures exhibited an unusual data pattern when having their …

Intergenic Regions And Repeating Gene Sequences In The Dinoflagellate Karenia Brevis, Colleen A. Gregg

Honors Theses

Karenia brevis is a species of dinoflagellates that is responsible for “red tides” (more formally known as harmful algal blooms) found in the Gulf of Mexico. The blooms have adverse effects on humans and marine animals. Karenia brevis produces toxins that, in humans, can cause upper and lower respiratory problems as well as nausea and vomiting. For marine mammals, birds, fish, and other marine organisms, exposure to brevetoxins can result in morbidity and even death.

Even with the technology and resources we have today, scientist do not fully understand the mechanisms behind toxin production and bloom initiation. Because cellular processes …

Assessing Behavior Change Related To Acute Stress Exposure In The Zebrafish, Christine E. Breazeale

Honors Theses

Stress affects how we function in all aspects of our lives. It is our physiological response to a threat. In fact, its origins were very adaptive. Stress can cause an animal to flee a predator and avoid being eaten. In today’s society, stress can prompt us to work harder to achieve a good education or promotion at work so that we can afford food, shelter, and entertainment. But stress can also impair performance at work, on tests, and even can cause long-term bodily harm. In order to fully understand the deleterious effects of stress and thereby properly treat it, it …