Digital Commons Network^™

Utilizing The Zebrafish Model To Determine Anti-Epileptic Properties Of Mistletoe And Cannabis, Collin Dietrich

Honors Theses

Epilepsy affects around 50 million people in the world, therefore improving treatment efficacy and safety for epileptics is imperative. In this study we sought to screen the effectiveness and safety of cannabis constituents (delta-9-tetrahydrocannabinol and cannabidiol) and Tapinanthus globiferus extracts in treating epilepsy. We used a zebrafish model wherein seizures were induced by treatment with pentylenetetrazol. Our results showed that Tapinanthus globiferus dose-dependently reduced seizure activity, and no toxicities were seen at the concentrations used. In contrast delta-9-tetrahydrocannabinol and cannabidiol did not significantly reduce seizure activity and some toxicities were seen at the higher concentrations tested. We conclude that extracts …

How To Be A Girl: The Discourse Of Compulsory Heterosexuality, Desire, And Adolescent Female Sexuality In Seventeen And Cosmopolitan Magazines From The Late 20th Century, Danielle Keiser

Honors Theses

This work explores the discourse of adolescent sexuality and desire presented to readers by Seventeen and Cosmopolitan magazines published between 1970 and 1989. The essay draws distinctions between articles and advertisements, pointing to those articles and ads that promote what Adrienne Rich called compulsory heterosexuality and those that encourage a less restrictive kind of femininity. The essay claims that Seventeen, because it targets a younger audience than Cosmopolitan does, promotes a more sexually normative framework of heterosexual relationships, compulsory matrimony, and motherhood for young readers. Cosmopolitan, on the other hand, teaches readers to embrace female sexuality and desire without needing …

Cadmium Disruption Of Calcium-Dependent Dimerization Of Neural Cadherin, Dylan Ritter

Honors Theses

Cadherins are a family of transmembrane proteins that dimerize to form junctions between cells in the presence of calcium. Due to the necessity for proper cell adhesion during cell differentiation in development, we are examining whether binding of other metallic divalent cations would disrupt calcium-sensitive dimerization of neural cadherin in vitro. Specifically, we are studying the effect of cadmium(II) on the linkage between calcium binding, dimerization, and dimer disassembly. Cadmium toxicity became recognized during the Industrial Revolution, with particular attention gained during the Itai-Itai disease outbreak in China during the 1910s. This toxicity, partnered with the role of cadherin in …

Pituitary Gland Functional Connectivity And Bmi, E. Paige Rucker

Honors Theses

This study examined the link between pituitary gland functional connectivity and BMI. The pituitary gland plays various roles in the body through the secretion of hormones, but its direct role in development of obesity and BMI management is unknown. Resting state functional Magnetic Resonance Imaging (rsfMRI) brain data of individuals with diverse BMIs were analyzed by voxel-wise analysis to determine the functional connectivities of the pituitary gland to other regions of the brain. A significant negative correlation was found between BMI and pituitary gland functional connectivity in eleven different brain regions. These regions include the posterior thalamus, lingual gyrus, precuneus, …

The Sociological And Economic Factors Impacting A Workforce Development Program In An Impoverished Community, Elena Bauer

Honors Theses

The purpose of this study is to inform about the best practices of workforce development, and to consider the sociological and economic factors in impoverished areas that are to be considered for successful traditional business principles to work. Through an in-depth study of eight African American male respondents who were participants in a job training program in Clarksdale, Mississippi, this study explores the impact of the vestiges of past discrimination embedded in the institutions and culture to make a Mississippi community particularly challenging for providing equitable opportunities for low income residents (Cobb, 1992; Duncan & Blackwell, 2014; Myers Asch, 2011). …

Spatial Variation Of Bacterial Communities On The Leaves Of A Southern Magnolia Tree, Emily Q. Nguyen

Honors Theses

The leaf surface, or phylloplane, is a dynamic environment for its microbial inhabitants, which can be subjected to many environmental factors. Existing phylloplane studies have focused on differences in bacterial community structure between trees of the same species, in different geographical locations, or between trees of different species. Few studies have examined the spatial distribution of bacterial communities on the leaves of a single tree. In this study, leaf samples from different areas of the canopy were obtained from a single Magnolia grandiflora tree. Samples were taken from the high (3.5-4.0 m above the ground), middle (1.5 m), inner middle …

Idealizing Patriarchy: Patterns Of Hierarchy And Patriarchal Values In English Household Literature, 1520-1600, Conor Howard

Honors Theses

This thesis examines English household literature of the sixteenth century to assess normative patterns of masculinity and patriarchy. Throughout that century, in spite of prolific changes having occurred in the realm of English material and intellectual culture, the patterns of masculinity observed in these texts show a remarkable pattern of consistency. This lack of change is in keeping with the works of other historians who have argued that the most salient feature of the norms of English masculinity throughout the early modern period was in fact continuity. Chapter one of this thesis shows how this body of literature prescribed access …

Occupational Differences In Play Between Monolingual And Bilingual Children In Kentucky, Miranda Massey

Honors Theses

This study looked at the occupational differences between monolingual and bilingual children in the state of Kentucky. The children were ages 7-12 years old and were divided into three categories: monolingual English-speaking, monolingual Spanish-speaking, and bilingual English and Spanish-speaking. Each child and their parent/guardian was interviewed to collect data on play habits to determine if language was a factor in the play choices. Subjects were selected through convenience sampling over social media and by word-of-mouth. From all possible participants collected, one child from each category was chosen for the interview process.

The process itself consisted of a 50 question child …

“Keeping Down The Underground:” The Underrated Value Of Indie Music Scenes As Economic Development Tools For Small American Cities, Meghan Mckinney

Honors Theses

Indie music holds the largest share of the global music market and is a multibillion-dollar industry. On a more local scale, indie music can contribute significant revenue to small American cities through locally owned independent record stores, live venues, and festivals. Each of these elements, with the addition of the people involved in indie music in a variety of capacities, interacts within a centralized location known as an indie music scene. Collectively, these scenes can generate massive amounts of revenue through music sales, ticket sales, tourism, and various other business offerings. To the small cities in which these scenes operate, …

"Literally Psycho"--Empathy For Those Who Have None, Through The Use Of Literature, Tyla Poindexter

Honors Theses

In today’s society, the word “Psychopath” gets thrown around very easily. But does society really know what it means to truly be a clinically diagnosed Psychopath? This thesis is all about uncovering the truth about what Psychopathy looks like, how Psychopathy is handled in the courtroom, and why people should not despise, but have empathy for Psychopaths. This was accomplished by writing a thrilling short story about a young clinical psychologist by the name of Dr. T Campbell who is assigned to interview a very charismatic man named Peter Vetrov for the court. Peter has been deemed guilty of 3 …

The Theoretical Application And Comparison Of The Olfactory Sensory Organs In Swine Vs Canines For Accelerant And Explosives Detection, Naomi M. Sigler

Honors Theses

Swine may be able to work alongside scent detection canines, or replace them completely, in the scent detection field. Miniature pigs are the focus of this study since their larger counterparts can cause damage to potential evidence and to the scene itself. Ignitable Liquid Residues (ILRs) are searched for in post-fire conditions, and unconsumed explosives are searched for in major transportation hubs. Swine have more functional olfactory genes and less pseudogenes than humans, canines, and mice. Swine also have a highly functioning and exceedingly organized olfactory system. Swine are social creatures, which allows them to bond with a distinct handler. …

Retinal Ganglion Cell Neuroprotection Induced By Neuropharmacological Agents In An In-Vivo Model Of Glaucoma, Quinn Ameel

Honors Theses

Recent discoveries from this lab have demonstrated that activation of alpha7 nicotinic acetylcholine receptors (α7 nAChRs) on retinal ganglion cells (RGCs) in the retina is linked to neuroprotection of RGCs that are typically lost in glaucoma-like conditions. Various chemical agents have been produced to increase overall neurotransmission of ACh from cholinergic neurons. DMP-543 is an agent that increases calcium release from cholinergic synaptic terminals. Donepezil is an acetylcholinesterase inhibitor that inhibits the breakdown of ACh in the synaptic cleft, prolonging ACh’s effect. In this study, the neuroprotective activity of these two agents was analyzed at the synapse between starburst amacrine …

Calculating And Analyzing Night Sky Brightness For The Commerce/Greenville, Texas Area, Rebecca Bosmans

Honors Theses

No abstract provided.

Prison Stories: A Qualitative Study Of Women’S Experiences In Prison, Lizeth Chapa

Honors Theses

The purpose of this study to provide a meaningful profile of women offenders that will deliver a comprehensive understanding on the problems women face while in prison so that treatment can address these issues. Qualitative methodology, specifically the use of an open-ended questionnaire is used to examine the lives and issues that women in prison face. The sample consists of females who have previously been incarcerated in the state of Texas. They completed a semi-structured open-ended questionnaire in order to assess their perceptions of: (a) factors that contributed to their criminal behaviors, (b) how being incarcerated has positively or negatively …

Sedimentology Of A Small Estuarine Marsh Along East (Pensacola) Bay, Florida, Jesse Pfadenhauer

Honors Theses

Sediment samples from a marsh along East (Pensacola) Bay were analyzed using various laboratory techniques. The color, magnetic susceptibility, organic content, carbonate content, and sediment size distribution of each sample was measured to attain an overall profile of the sedimentary characteristics of the area. Using the GPS coordinates of each collection site, samples were categorized into sub-environments based on their position within the marsh. The trends within the study area and sub-environments were evaluated and interpreted. The data indicate that this marsh is a siliciclastic, fining-inland area that is frequently inundated with tidal fluctuations and storm surges. These storm surges …

Functional Significance Of Branch Points In Mirtrons, Britton A. Strickland

Honors Theses

MicroRNAs are a heterogeneous group of small regulatory RNAs generated by many pathways. Mirtrons (miR) are a class of microRNAs produced by splicing, and some mirtrons contain a 3’ tail located downstream from the self-complementary hairpin. During RNA splicing, a loop-like “lariat” intermediate structure is created when the 5’ end of the RNA is attached to an adenine called the branch point. The goal of this project is to uncover the contribution of branch point location to the processing of tailed mirtrons into functional gene regulators. This project approaches this issue from two directions. First, branch points were identified by …

Expression Of Glycine-Rich Proteins Found In Salivary Glands Of The Lone Star Tick (Amblyomma Americanum) Using A Mammalian Cell Line, Annabelle Clark

Honors Theses

Ticks play an important ecological role as well as a growing role in human health and veterinary care. Ticks are hosts to a plethora of microbial pathogens that can be transferred during feeding to cause tick-borne diseases in humans and many animals. Ticks may in large part owe the success of the transfer of these pathogens between hosts to their complex saliva. The saliva secreted upon a tick’s attachment to a host serves the following, among other, functions: anti-hemostasis of the blood pool, preventing an inflammatory response at the bite site, and serving as a natural anti-microbial substance. An important …

Gender Roles And Gender Stereotypes In Four Newbery Award-Winning Books, Alex P. Brower

Honors Theses

This research project examined the presentation of traditional gender roles and representation in four books that were awarded the Newbery Medal. The four books that were examined are the award recipients from 1922, 1923, 2014 and 2015. It was predicted that as gender equality has become a more prominent issue, and men and women have become more equal, one would expect this change to be reflected in children’s literature. A close reading was performed of these works, and special attention was paid to how the authors present the genders of the main characters in terms of personal interests, the roles …

Mating Behaviors Exhibited By A Captive Male Pacific Walrus (Odobenus Rosmarus Divergens), Jessica M. Mccord

Honors Theses

Understanding mating behaviors of a species can be utilized to help protect the species. Results of population surveys have shown the walrus population to be on the decline, and over the history of walruses being held in captivity, few pups have been born or survived. Not much is known about Pacific walruses (Odobenus rosmarus divergens) due to the isolated Arctic habitats in which walruses live making wild population studies difficult. Few studies have examined wild observations of walrus mating behaviors and virtually none for captivity. The purpose of this study was to observe a captive male Pacific walrus for mating …

Marketing Ideas That Could Improve Adoptions And Reduce Return Rates Of Dogs In Shelters In The State Of Michigan, Bryan Klemett

Honors Theses

Dogs have always been something that attracts people’s attention. It is hard to decide whether it is their fur, their cuteness, or their personality that makes them lovable. The area I chose to conduct my research is in marketing. Since dogs are man’s best friend, what other better way is there to do a thesis than on something so lovable? This research entails marketing ideas that could increase adoption rates while reducing return rates of animals at shelters in the State of Michigan.

I chose this topic because as it is stated earlier, I am a dog lover. I have …

Curiosity Beyond The Classroom: Developing Engaging Education Programming At The Grand Rapids Public Museum, Sara Forman

Honors Theses

This project was designed to examine the impact of museums as authentic learning environments for traditional students, and analyze the role of student-centered educational programming in such an environment has upon student’s growth and connection to social studies content. The aim of this project was to develop an education program for secondary students, implement the program in a museum setting, and assess its effectiveness in encouraging student growth. The education program was created and taught at the Grand Rapids Public Museum (GRPM) in relation to the exhibit, Whales: Giants of the Deep. The program was developed under the supervision of …

Research Methods Used To Study Pharmacological Intervention Of Nicotine-Induced Breast Cancer Formation And Metastasis, Bethany Breakall

Honors Theses

The effects of iPLA₂β (Ca²⁺-independent Phospholipase A₂β) and MMP-9 (Matrix Metalloproteinase-9) have been a recent focus of research in the progression of cancer cell proliferation and migration. However, their roles are not entirely known, especially concerning nicotine-induced breast cancer cell advancement. The purpose of this study was to determine the involvement of iPLA₂β in nicotine-induced breast cancer cell proliferation. BEL (bromoenol lactone), a suicide inhibitor of iPLA₂β, was hypothesized to attenuate nicotine-induced breast cancer cell proliferation and tumor growth. Following the BEL treatment, the in-vitro results exhibited a significant decrease …

Winter Ecology And Behavior Of Eastern Towhees At Taylor Fork Ecological Area, Megan Martin

Honors Theses

The Eastern Towhee (Pipilo erythropthalmus) is a type of sparrow, which has declined in number by about 50% since the mid-1960s. Since both their summer and winter habitat use is affected by changes in the prevailing vegetation, it is possible that the declining populations are a result of factors in both breeding and nonbreeding seasons. The objective of the study was to describe the behavior, habitat use, and foraging habits of the Eastern Towhee during the winter at a site in central Kentucky. Nine Towhees were captured, radio-tagged, and tracked using homing and triangulation for a total of …

The Calusa And Early Spanish Settlement: An Archaeological-Historic Analysis Of Early European Contact In Southern Florida, Rylan Cromer

Honors Theses

In 1513 Juan Ponce de León led an expedition force to explore the western coastline of Florida as part of a mission for the Spanish Crown to map the Gulf of Mexico and determine the capability of the area to potentially support Spanish colonization attempts. Instead, León established first contact with a powerful native society that successfully drove León and his fleet of three ships from their shores with nothing more than bows and basic dugout canoes. For nearly a century afterward, the mere presence of these people, the Calusa, was enough to limit Spanish settlement to the Eastern coastline …

Fanfiction Communities And Plagiarism: An Academic Inquiry, Claudia I. Hicks

Honors Theses

Fanfiction communities give would-be authors a place to practice their craft. This study focused on how fanfiction community members defined and policed plagiarism. The aim of this study was to conduct qualitative analysis of plagiarism cases in online fanfiction communities. The data sources were analyzed using Grounded Theory. Analysis found that fanfiction communities use certain protocols to police plagiarism except when it violates their highest value, popularity. This study contributes to our understanding of plagiarism in a digital age.

Bodies Unbroken: Disability In Indra Sinha's Animal's People And Katherine Dunn's Geek Love, Hannah C. Baker

Honors Theses

This project explored the representation of physical disability in modern fiction with the hope to prove that disabled characters are receiving more complex and complete treatment in fiction as a reflection of social change, progress that is also supported by the growing field of disability scholarship. I will explore how two contemporary novels depart from older conventions of representing the disabled as static symbols of good or evil or as broken persons who need to be fixed. Scholars in both English and Disability Studies have commented on these problems, and their insights informed my argument.

Furthermore, I will explore the …

The Phenology And Compatibility Of Hazelnut (Corylus Avellana) Cultivars In Tennessee, Ben Nigel Heard

Honors Theses

The European hazelnut (Corylus avellana L.), is an important temperate zone nut tree species for which there is an expanding demand worldwide. Historically, the Eastern filbert blight disease (EFB), caused by the ascomycete fungus Anisogramma anomala, has prevented commercial hazelnut growing in Tennessee. As part of a UTC hazelnut cultivar trial, EFB resistant hazelnut cultivars and numbered selections from Oregon State University and Burnt Ridge Nursery were planted in 2003 at Smith Farm in Ooltewah, TN. Hazelnut trees are wind-pollinated, dichogamous, and self-incompatible, which means they are not self-fertile, their male and female blossoms may open at different times, and …

Private Vs. Public Healthcare In South Africa, Montgomery Young

Honors Theses

This paper explores the South African healthcare system in regards to the gap between the private and public healthcare sectors. Public healthcare is government funded and offered to all citizens of South Africa, but there are many disadvantages such as long wait times, rushed appointments, old facilities, and poor disease control and prevention practices. Citizens can opt to purchase private insurance in order to be treated at private hospitals and health clinics. The private healthcare sector has many perks that set it apart from public healthcare, such as short wait times, appointments are not rushed, better facilities, and proper disease …

(Mis)Representation By Bravo: Maintaining/Countering Stereotypes Of Black Women On Reality Television, Michelle Mayfield

Honors Theses

This honors thesis investigates the use of stereotypes used to portray Black women on reality television.  Focusing on Bravo’s Blood Sweat and Heels, this project utilizes an Afrosemiotic framework, which is a combination of Afrocentricity and Semiotics.  Afrocentricity focuses on the agency and consciousness of Africans and African Americans.  Semiotics focuses on the study of signs and the explicit and implicit markers of these signs.  The first season’s narrative focuses on the positive lives of single, successful Black women but shifts to mainly negative portrayals inspired by Bravo’s Real Housewives franchise.  This project focuses on stereotypes associated with Black …

Learning And Memory In A Drosophila Melanogaster Model Of Alzheimer's Disease, Eric Robles

Honors Theses

Human Alzheimer's disease (AD) is the most prevalent and lethal neurodegenerative disease; it involves the accumulation of neurofibrillary tangles, loss of synapses and neurons in specific areas of the brain, and the presence of extracellular amyloid plaques, particularly Amyloid beta-42 (AP-42). In this study, two Drosophila transgenic fly lines carrying either elav-GAL4 driver or UAS-AP-42 transgene, were crossed to generate AD flies that expressed low levels of human Ap-42. Male AD flies (experimental) and elav-GAL4 flies (as parental control without AP-42) were tested for learning and short-term memory using the courtship suppression assay (Siegal and Hall, 1979). The courtship suppression …