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Cancer Heterogeneity And Mitochondrial-Targeted Therapies In Cancer Cachexia, Francielly Morena Clark
Cancer Heterogeneity And Mitochondrial-Targeted Therapies In Cancer Cachexia, Francielly Morena Clark
Graduate Theses and Dissertations
Cancer Cachexia (CC) is a multifactorial and complex syndrome affecting up to 80% of cancer patients and contributing to approximately 40% of cancer-related deaths. Given its relationship with patients' quality of life and prognosis, there has been increasing emphasis on understanding the underlying mechanisms of CC using pre-clinical models. However, the mechanisms of cachexia vary depending on several factors, including tumor type, model, and biological variables such as sex. RNA-sequencing technology is a crucial tool for investigating CC heterogeneity, enabling the analysis of the transcriptome across different models, conditions, and sexes using publicly available data. Aim 1 of this dissertation …
The Impact Of Ectopic Expression Of A Plant Elicitor Peptide In Bacillus Subtilis On Nematode Resistance In Soybean Through Seed Treatment, Abeer Alnasrawi
The Impact Of Ectopic Expression Of A Plant Elicitor Peptide In Bacillus Subtilis On Nematode Resistance In Soybean Through Seed Treatment, Abeer Alnasrawi
Graduate Theses and Dissertations
Soybean (Glycine max) is the most beneficial legume crop because it is a source of protein as well as oil for humans and livestock. Soybean is the second most planted crop in the United States following corn and it is also the fourth planted crop worldwide. However, the soybean cyst nematode (Heterodera glycines, SCN) is the most damaging pest of soybean in the United States, accounting for more than twice as much yield loss as the following cause of yield loss in soybean. Therefore, there is a pressing need to develop alternative management strategies to control SCN infection in soybeans. …
Proton-Coupled Electron Transfer To Drive Biomass Conversion, Cody Canote
Proton-Coupled Electron Transfer To Drive Biomass Conversion, Cody Canote
Graduate Theses and Dissertations
Meeting rising demands for commodity chemicals while simultaneously easing reliance on fossil fuels presents one of the most substantial challenges for chemistry to date. Biomass has emerged as a sustainable precursor to commodity chemicals but requires substantial deoxygenation to displace petrochemicals. Development of efficient catalysts to achieve these transformations remains one of the central goals of inorganic and organometallic chemistry. Electrochemical strategies to propel biomass conversion are attractive, providing the driving force for reactivity and insights into catalyst mechanism. This work focuses on proton-coupled electron transfer (PCET) to facilitate redox catalysis in biomass up conversion and homolytic bond cleavage in …
A Two-Part Validation Study Of The Sexual Minority Identity Emotion Scale, Henrietta Kadi Tettey-Tawiah
A Two-Part Validation Study Of The Sexual Minority Identity Emotion Scale, Henrietta Kadi Tettey-Tawiah
Graduate Theses and Dissertations
A number of existing studies indicate that there is some correlation between pride and shame and various behavioral health outcomes like anxiety, depression, and self-harm in the general population. Research also confirms that this relationship is true among sexual minorities as well. This study sets itself up to interrogate this assertion vis-à-vis sexual minority adolescents (SMAs). Consequently, confirmatory factor analysis (CFA) and differential item functioning (DIF) detection analysis were performed on the 35-item Sexual Minority Identity Emotion Scale (SMIES) for SMAs. A tree-based modeling technique, specifically conditional inference trees (CIT), was then employed to explore and make predictions about the …
Ideological Becoming During Student, Preservice Teacher, And First-Year Teacher Experiences, Holly Sheppard Riesco
Ideological Becoming During Student, Preservice Teacher, And First-Year Teacher Experiences, Holly Sheppard Riesco
Graduate Theses and Dissertations
In the first manuscript in Chapter 2, this study examines two teachers’ talk about literacy as they describe literacy events and practices throughout multiple contexts. Drawing the theoretical framework of discourse and literacy as a social practice, this research illustrates the potential ways these first-year English teachers talk and have talked about literacy during their time as English methods students to their student teaching experience in their current contexts. Findings illustrate that the teachers assimilated and adapted their literacy ideologies early but continued evolving their understanding of literacy across various contexts. Implications for teacher education include considering literacy events through …
Motives For And Consequences Of Deception In Romantic Relationships, Breanna De Leeuw
Motives For And Consequences Of Deception In Romantic Relationships, Breanna De Leeuw
Graduate Theses and Dissertations
The goals of this study are twofold. First, I examined the influence of sex, relational intimacy, and face concerns on deploying deceptive communication within romantic relationships. Second, I investigated the impact of deceptive communication on relational commitment and relationship satisfaction. Two hundred twenty-two college-aged students completed self-report measures assessing the variables of interest. Results demonstrated that men and women deceive their romantic relationship partners at similar rates; however, deception is differentially motivated across the sexes. In addition, results indicated that relational intimacy was negatively associated with the frequency of deceit, although relational intimacy was not significantly associated with specific motives …
Diversity Equity And Inclusion Education: An Evaluation Of The Safe Zone Allies Program, Shannon E. Hart
Diversity Equity And Inclusion Education: An Evaluation Of The Safe Zone Allies Program, Shannon E. Hart
Graduate Theses and Dissertations
Diversity, Equity, and Inclusion gained unprecedented popularity from 2019 to 2022. The tide turned in 2023, and Anti-DEI legislation continues to gain momentum nationwide. This backlash may be warranted, as research demonstrates that DEI can backfire. DEI programs remain unregulated, understudied, and often paradoxically under-supported despite their potential to catalyze positive social change. Two studies were conducted to begin creating standardized, accessible, and evidence-based DEI best practices. Safe Zone Allies, a LGBTQIA+ specific DEI program was selected for program review because; (a) it was not developed hastily, (b) it was not siloed, and (c) the curriculum is evidence-based. The first …
What Is A Person? How Does One Become A Morally Good Person? The Intuitive View!, Tancredo Tivane
What Is A Person? How Does One Become A Morally Good Person? The Intuitive View!, Tancredo Tivane
Graduate Theses and Dissertations
This thesis centers around two philosophical problems: the concept of a person and the process by which one becomes a morally good person. Drawing on the works of philosophers such as Harry Frankfurt, Strawson, and A.J. Ayer, it begins with an inquiry into what it means to be a person. It argues that while humanhood, with its rational capacities, is a contingent rather than a necessary condition, it can serve as an accurate predictor of personhood. The thesis posits that personhood is an achievement rather than an inherent state, facilitated by interactions within a social framework that refine these rational …
Beyond Single Connections: An Exploration Of How Overlapping Networks Drive Policy Change Among State Legislators, Melanie B. Hoskins
Beyond Single Connections: An Exploration Of How Overlapping Networks Drive Policy Change Among State Legislators, Melanie B. Hoskins
Graduate Theses and Dissertations
Current research on policy diffusion and innovation primarily focuses on the policy idea as the unit of analysis. While diffusion studies incorporating social network theory often examine networks at the collective entity-level, they tend to neglect the actions of individual members. This study investigates how state legislators' exposure to novel policy ideas through their multiplex network ties influences their sponsorship of related bills and how legislators’ collaboration and coordination within these networks may significantly impact public policy outcomes. This three-article dissertation addresses three key areas by: 1) examining Arkansas legislators' participation within the American Legislative Exchange Council (ALEC) network; 2) …
Investigating The Detection And Transport Of Low Molecular Weight Species To Better Understand Their Impact On Disease Pathology And Treatment, Haley Michelle Duncan
Investigating The Detection And Transport Of Low Molecular Weight Species To Better Understand Their Impact On Disease Pathology And Treatment, Haley Michelle Duncan
Graduate Theses and Dissertations
Due to the drastic differences in the projects involved, this dissertation will be split into two sections: Alzheimer’s disease and chronic kidney disease. Each chapter will contain an introduction, materials and methods section, results and discussion, conclusions, and works cited section. The Alzheimer’s disease chapter will also have a supplemental figures section containing the polyacrylamide gels that were silver stained and quantified via ImageJ. The presence of elevated levels of amyloid beta oligomeric species in the brain has been related to the pathology of Alzheimer’s disease. As these oligomeric species are transient in nature, their kinetics pose a challenge to …
Cover-Crop Effects On Near-Surface Soil Properties Over Time In The Lower Mississippi River Valley, Cooper Fanning
Cover-Crop Effects On Near-Surface Soil Properties Over Time In The Lower Mississippi River Valley, Cooper Fanning
Graduate Theses and Dissertations
Human population growth and climate change are present stressors that continue to put pressure on current agricultural production systems, where typical row-crop agricultural practices can negatively impact soil health. Extensive use of cover crops (CC) to increase soil health remains widely unrealized. Soil health in Arkansas is a major concern for sustaining agricultural output, therefore research into CC implementation across Arkansas to maintain or improve soil health is needed. The objective of this study was to evaluate the effects of CC (i.e., with and without CC) across various physical, hydraulic, biological, and chemical soil indicators in the Lower Mississippi River …
Leveraging Machine Learning And Stochastic Programming To Address Vaccine Hesitancy In Public Health Resource Allocation, Hieu Trung Bui
Leveraging Machine Learning And Stochastic Programming To Address Vaccine Hesitancy In Public Health Resource Allocation, Hieu Trung Bui
Graduate Theses and Dissertations
Infectious disease outbreaks highlight the urgent need for effective strategies to distribute vaccines and allocate critical healthcare resources to contain the disease and reduce its negative impacts on the population. Managing these allocations is a significant challenge, especially in marginalized communities facing uncertainty in healthcare demand and logistical constraints. This dissertation addresses these challenges by investigating factors that influence dynamic changes in vaccine hesitancy (VH) and its implications for disease spread and healthcare resource demand. It develops optimization models for vaccine distribution and resource allocation under uncertainty, validated with data from the COVID-19 pandemic in the U.S. The first study …
Modeling Enterococcus Cecorum Horizontal Transmission To Investigate The Impact Of Perinatal Exposure On Extraintestinal Colonization, Disease Presentation, And Performance In Young Broiler Chickens, James Y. Higuita Valle
Modeling Enterococcus Cecorum Horizontal Transmission To Investigate The Impact Of Perinatal Exposure On Extraintestinal Colonization, Disease Presentation, And Performance In Young Broiler Chickens, James Y. Higuita Valle
Graduate Theses and Dissertations
Enterococcus cecorum (EC) has primarily been associated with osteomyelitis and lameness in older chickens. The recent emergence of pathogenic EC causing morbidity and mortality in young broiler chicken flocks requires further investigation. The purpose of this thesis was to develop a model to simulate horizontal transmission of virulent EC during the hatching phase in small scale hatchet cabinets. The model will be used to investigate novel pre- and post-hatch strategies to mitigate EC infections in young broiler chickens. The current thesis contains four chapters. Chapter I includes the thesis introduction. A literature review focusing on EC-associated disease in chickens, with …
Essays On Empirical Investigation Of Extended Warranties Of Consumer Electronics, Vasavi Rayachoty
Essays On Empirical Investigation Of Extended Warranties Of Consumer Electronics, Vasavi Rayachoty
Graduate Theses and Dissertations
Extended warranties (EW) have gained significant traction as a powerful revenue stream for retailers, boasting substantial profit margins ranging from 50% to 70% (Bloomberg week). These warranties offer consumers peace of mind by providing additional protection beyond the standard manufacturer warranty and are to be purchased at an additional cost. By offering extended warranties, retailers can differentiate themselves in a competitive market, build stronger customer relationships, and enhance their overall profitability. However, effectively capitalizing on their potential necessitates a strategic approach. The extant literature is focused on studying extended warranties from the perspective of a consumer and lacks a retailer …
Three Essays Examining Technology Adoption And The Role Of Physicians In Improving Efficiency, Quality And Reducing Risk In Healthcare Supply Chains, Rajib Dutta
Graduate Theses and Dissertations
Hospitals across the USA are operating under extreme financial stress and looking for opportunities to improve financial stability and maximize bottom-line savings. As supply chain function accounts for up to 40 percent of total hospital operating cost, hospital leaders are increasingly viewing the healthcare supply chain as a potential area for efficiency gain and cost reduction. The recipe for effective and efficient care delivery is to synchronize the flow of supplies with patient needs by integrating products, processes, and information while complying with government regulations. Therefore, proper management of inventory, role of government policies in shaping hospital strategies, adoption of …
High-Power Power Conditioning Systems For Medium-Voltage Applications, Ahmed Rahouma Fares Rahouma
High-Power Power Conditioning Systems For Medium-Voltage Applications, Ahmed Rahouma Fares Rahouma
Graduate Theses and Dissertations
The purpose of this dissertation is to address the background, theoretical analyses, design methodologies, and evaluation techniques relevant to high-power power conditioning systems (PCSs) tailored for medium-voltage (MV) applications. Conventional PCSs, reliant on line-frequency transformers (LFTs), suffer from many problems including low power densities, inflexible designs, and scalability constraints. Employing multilevel converters (MLCs), particularly cascaded H-bridge topology, eliminates the need for these LFTs. A key focus lies in minimizing the number of cascaded building blocks by harnessing MV power switching modules. The dissertation makes two primary contributions: firstly, it offers a design methodology for MV-PCS, facilitating the selection of the …
Essays On Membership Retailing In Omnichannel World, Aashish Pandey
Essays On Membership Retailing In Omnichannel World, Aashish Pandey
Graduate Theses and Dissertations
The retail industry in the United States has experienced significant and sustained growth, with sales surpassing $7 trillion in 2022, reflecting a dynamic and competitive landscape. This growth has been particularly evident in the evolution of retail formats over the past four decades, marked by a decline in the market share of grocery stores and a corresponding increase in the dominance of supercenters and membership clubs. Membership club stores such as Sam’s Club, Costco, and BJ’s have emerged as key players, offering consumers access to large quantities of goods at lower prices, albeit requiring an annual membership fee. This dissertation …
Investigating The Applications Of Peps To The Measurement Of The Stabilities Of Staphylococcal Nuclease (Stw) And Human Acidic Fibroblast Growth Factor (Hfgf1), Motolani Omolade Matthew
Investigating The Applications Of Peps To The Measurement Of The Stabilities Of Staphylococcal Nuclease (Stw) And Human Acidic Fibroblast Growth Factor (Hfgf1), Motolani Omolade Matthew
Graduate Theses and Dissertations
This dissertation presents a detailed investigation into the applications of Protein Equilibrium Population Snapshot H/D Exchange Electrospray Ionization Mass Spectrometry (PEPS-H/D exchange or PEPS) method. This method is based on protein equilibrium unfolding, and its fundamental capability is to capture a "snapshot" of the protein's state, allowing us to monitor the ratio of the unfolded to folded populations at different chemical denaturant concentrations. First, to increase the accuracy of PEPS data analysis for assessing protein stability, the traditional linear extrapolation method (LEM) was replaced. Instead of using LEM, which calculates free energy change based on the peak ratio of unfolded …
Partial Immunity To Mycoplasma Gallisepticum After An Initial Infection Is Long-Lasting And Reduces Transmission In Flocks Of Canaries, Madeline Sudnick
Partial Immunity To Mycoplasma Gallisepticum After An Initial Infection Is Long-Lasting And Reduces Transmission In Flocks Of Canaries, Madeline Sudnick
Graduate Theses and Dissertations
Pathology during a second infection can be influenced by immunity and an increase in resistance or tolerance of individuals. Population-level differences in the ability to maintain immunity can lead to contrasting survival outcomes between groups and determine how future outbreaks will spread. However, long term wildlife disease surveillance can be challenging due to lack of infrastructure and host-pathogen specific tests. Calculating disease transmission likelihood requires understanding individual-level heterogeneity in pathology and behavior, and there is limited knowledge in understanding how populations in different stages of an epidemic will transmit disease. In Chapter I, we aim to help fill a gap …
Parallel Degree Planning In The Pursuit Of Academic Success For Pre-Nursing Students In A Competitive Entry Baccalaureate Nursing Programs, Elizabeth L. Mckinley
Parallel Degree Planning In The Pursuit Of Academic Success For Pre-Nursing Students In A Competitive Entry Baccalaureate Nursing Programs, Elizabeth L. Mckinley
Graduate Theses and Dissertations
This study sought to understand the student perceptions of parallel academic degree planning for the competitive entry undergraduate Nursing program at a case study university. Parallel degree planning is a relatively new term of alternative curricular planning. The qualitative study includes nine students and their experiences in planning for their intended major while simultaneously planning courses that meet another major or degree program, and understanding how parallel degree planning aided their retention and student satisfaction as well as their academic advisor interaction. The study was completed at a research university where the Nursing program has a very lower acceptance rate, …
Friendship Intimacy: A New Approach To Valuing Friendship, Benjamin Lugo
Friendship Intimacy: A New Approach To Valuing Friendship, Benjamin Lugo
Graduate Theses and Dissertations
There is a tradition in moral theory that holds that friendship is necessary for living well. That is, if our aim is to live a good life or a flourishing life, then that life will include building and maintaining friendships. Aristotle and Plato both share this view and express similar claims about the necessity of friendship for the pursuer of a good life. Contemporaries of both have spent time interpreting their claims and have long commented on the intrinsic value of friendship. I pick up on a strand of the debate by exploring the purported value of friendship. While considerable …
Desire Lines: Reading Queerly Through The Forests Of Medieval Love Literature, Brianna Skye Oliver
Desire Lines: Reading Queerly Through The Forests Of Medieval Love Literature, Brianna Skye Oliver
Graduate Theses and Dissertations
This dissertation conducts queer eco-sensitive readings of a selection of medieval love texts in Middle English and Old French. Informed in turns by the works of feminist, queer, and ecocritical scholars, each chapter engages with a different iteration of literary queerness by bringing the representation of natural spaces and objects (especially the forest) to the fore and reading through nature depicted in the texts. The readings all share a broad goal of inviting modern audiences to play with desire and its manifestations within each text to make meaning and compel intimacy between the work and its current audience. Chapter 1 …
An Exploratory Multiple Case Study Of Special Education Transition Program Structures In Virtual Public Charter Schools, Krystle Merry
An Exploratory Multiple Case Study Of Special Education Transition Program Structures In Virtual Public Charter Schools, Krystle Merry
Graduate Theses and Dissertations
This dissertation research is an exploratory multiple-case study of special education transition program structures in three virtual public charter schools in a southern state in the United States. Virtual public charter schools are extensions of public school systems or districts that are required to comply with state and federal-mandated special education transition services to ensure students with disabilities receive a Free Appropriate Public Education (FAPE) under the Individuals with Disabilities Education Act (IDEA, 2004). This study aims to explore transition Program Structures within the Taxonomy for Transition Programming 2.0 (Kohler et al., 2016) at the systemic level based on the …
To Be Framed: Investigating The Influence Of American Media Frames On Gun Control, William C. Chamblee
To Be Framed: Investigating The Influence Of American Media Frames On Gun Control, William C. Chamblee
Graduate Theses and Dissertations
Gun control may be one of the most polarizing political issues facing America today. While there are many factors that contribute to gun control controversy, one may be how it is framed by news organizations. Research suggests that the emergence of partisan news media, differing levels of issue salience, and the public’s increased willingness to selectively expose could widen the gap between both Republicans and Democrats through their opinions on the issue of gun control, causing polarization. Using a survey, this study found that both Republicans and Democrats are likely to selectively expose to partisan media outlets and that a …
Effects Of Land Cover And Land Change On Monarch Butterfly Presence Across The Conus, Chris R. Burkhart
Effects Of Land Cover And Land Change On Monarch Butterfly Presence Across The Conus, Chris R. Burkhart
Graduate Theses and Dissertations
The decline of monarch butterfly populations (Danaus plexippus L.) over the past four decades, particularly in their overwintering habitats, has raised concerns about the species' conservation. Habitat loss and modification, particularly within the contiguous United States, are attributed as one of the key drivers of this decline. However, the specific impact of land use and land cover (LULC) changes on monarch distributions remains inadequately documented. This study integrates monarch observations from multiple sources spanning 2008 to 2019 with LULC data to analyze the relationship between habitat configuration and monarch presence. Using a randomized grid sampling approach, habitat configuration metrics were …
Influence Of Invasive Species, Drought, And Stream Permanence On Stream Crayfish Species With A Focus On The Imperiled Mammoth Spring Crayfish (Faxonius Marchandi), Leah Marie Bayer
Graduate Theses and Dissertations
Freshwater crayfish constitute one of the most-threatened taxonomic groups in North America. Invasion by other crayfish species as well as habitat degradation through alteration of natural flow regime are two of the most prominent threats to crayfish persistence. Additionally, extreme weather events like droughts can amplify threats posed by other stressors on crayfish populations and are expected to increase in frequency, magnitude, and/or duration in the future, which may negatively influence narrow-ranged endemic crayfish populations typical of the Southeast. The Mammoth Spring Crayfish, Faxonius marchandi, is a narrow-ranged endemic that occurs in the Spring River drainage of Arkansas and Missouri …
Strategies For Misinformation Correction: Evidence For The Power Of Negation, Angel Houts
Strategies For Misinformation Correction: Evidence For The Power Of Negation, Angel Houts
Graduate Theses and Dissertations
The current study investigated the effectiveness of different correction strategies for misinformation using a 2 (Source: no source, credible source) x 2 (Structure: negation, affirmation) within-subjects design with an additional control condition that had no corrections. Participants read 40 Twitter-like statements, which included 25 pieces of misinformation and 15 truthful statements, and rated their emotional responses on a Likert scale. After completing a distractor task, participants read additional Twitter-like statements across five different conditions. The first four conditions aimed to correct misinformation: negation with a credible source, negation without source, affirmation with a credible source, affirmation without source. The fifth …
Struvite Effects On Greenhouse Gas Emissions From Flood- And Furrow-Irrigated Rice In The Greenhouse, Chandler Arel
Struvite Effects On Greenhouse Gas Emissions From Flood- And Furrow-Irrigated Rice In The Greenhouse, Chandler Arel
Graduate Theses and Dissertations
Over time, as the influences of climate-change and declining, mineable, global phosphorus (P) reserves begin to impact agricultural production systems, alternative fertilizer sources and management practices, such as struvite (MgNH4PO4 · 6H2O) and furrow-irrigation, will be necessary to accommodate nutrient and water demands. The precipitation and use of struvite as a fertilizer-P source could reduce environmental damages caused by nutrient-rich wastewater streams, supplement domestic P supply, and improve the sustainability of flood-, and furrow-irrigated rice production by reducing greenhouse gas emissions. The study of struvite from both chemical and electrochemical precipitation processes is well documented, …
Atypical Responses To Sensory Stimuli Or Eating Environments In Children With Autism Spectrum Disorder, Lydia Rockers
Atypical Responses To Sensory Stimuli Or Eating Environments In Children With Autism Spectrum Disorder, Lydia Rockers
Graduate Theses and Dissertations
Children with autism spectrum disorder (ASD) often encounter challenges in processing sensory inputs. Children with ASD may experience feeding difficulties and over- or under- stimulation during food-related activities such as eating or shopping. These have impacts on the health and well-being of individuals with ASD in childhood and throughout their lives. Further research is needed to address the impact of ambient sound levels in a retail or restaurant setting. The main objective of this thesis was to address these gaps by identifying responses to various environmental and food related stimuli. The findings of this research addressed differences in responses between …
Understanding The Emergence Of Self-Determination In Children With Disabilities Through Family Experiences In Early Childhood: A Qualitative Study, Karen K. Lange
Graduate Theses and Dissertations
Abstract A person’s ability to be self-determined begins to develop through the earliest interactions in life within the context of the family and caregiving environments. This qualitative phenomenological study of the experiences of eight parents representing seven families of young children explored how families promote their children’s early development of the skills, abilities, and attitudes of self-determination. The critical importance of the family context for the promotion of self-determination in young children is seen in the four themes that emerged from the experiences shared by these families. (1) The family context is transformed by a child with a disability, changing …