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Association Of Individual And Combined Metabolic Risk Factors With Cancer, Ruchi Bhandari
Association Of Individual And Combined Metabolic Risk Factors With Cancer, Ruchi Bhandari
Graduate Theses, Dissertations, and Problem Reports (ETD)
Introduction: The prevalence of metabolic risk factors (MRFs), individually and in the aggregate, is growing rapidly. There is limited biologic and epidemiologic evidence indicating an association between MRFs and cancer. The goal of this dissertation was to examine the association between individual and combined MRFs with subsequent risk of overall and site-specific cancers of the breast, digestive system, and lung.;Methods: A systematic review with meta-analysis on the association between metabolic syndrome (a cluster of MRFs) and breast cancer was conducted. In addition, associations between MRFs and risk of overall and site-specific cancers were assessed by multivariable Cox proportional hazards regression …
Influence Of Weight Loss On Metabolic And Mitochondrial Function In The Mature Horse, Jennie L. Zambito
Influence Of Weight Loss On Metabolic And Mitochondrial Function In The Mature Horse, Jennie L. Zambito
Graduate Theses, Dissertations, and Problem Reports (ETD)
Obesity causes a multitude of metabolic issues in the horse, yet stepwise alterations in glucose and lipid metabolism, mitochondrial capacity and oxidant status during weight loss have yet to be analyzed. Skeletal muscle contains subsarcolemmal (SSM) and interfibrillar (IFM) mitochondria, which respond differently to physiological stimuli, impacting tissue and whole body oxidant status. We hypothesized that 8 light-type horses would display improvements in skeletal muscle mitochondrial subpopulation function and decreases in circulating oxidant status markers during weight loss from an obese (7 to 8) to moderate (5) body condition score (BCS). Additionally, we hypothesized improvements in morphometric measurements, circulating metabolic …
Characterizing Peripheral Cellular And Humoral Immune Responses To Haemonchus Contortus In Sheep, Jesica Rae Jacobs
Characterizing Peripheral Cellular And Humoral Immune Responses To Haemonchus Contortus In Sheep, Jesica Rae Jacobs
Graduate Theses, Dissertations, and Problem Reports (ETD)
Gastrointestinal nematode parasitism is the most widely reported health concern among sheep producers worldwide. The most concerning of which is Haemonchus contortus; a blood-sucking nematode found in the abomasum of sheep. Worldwide anthelminthic resistance has prompted exploration of alternative methods of parasite control. Many studies have shown St. Croix hair sheep posses an immunologically mediated resistance to H. contortus infection, however no studies have utilized a true parasite naive animal for immune characterization. In this study, development of peripheral immune response was characterized in parasite resistant St. Croix lambs and parasite susceptible Suffolk crossbred Lambs. Lambs were separated into three …
The Effects Of Artificial Photoperiod On Age At Puberty In Fall-Born Ewe Lambs, Matthew Lewis Deacon
The Effects Of Artificial Photoperiod On Age At Puberty In Fall-Born Ewe Lambs, Matthew Lewis Deacon
Graduate Theses, Dissertations, and Problem Reports (ETD)
A study, conducted in two replicates, examined the effects of an artificial photoperiod on puberty in fall-born ewe lambs. Replicate I was initiated in December 2011 with prepubertal Dorset ewe lambs (n = 44). Replicate II was initiated beginning in December 2012 and included prepubertal Dorset, Suffolk x Dorset and Texel x Dorset ewe lambs (n = 52). All lambs were weighed at the initiation of each replicate and randomized to one of two treatments, control or treated, based on age, weight, breed and type of birth and rearing. Control ewe lambs were housed in a barn with exposure to …
Evaluation Of A Nurse-Led Intervention To Improve Palliative Care For Select Medical Intensive Care Patients, Lori A. Constantine
Evaluation Of A Nurse-Led Intervention To Improve Palliative Care For Select Medical Intensive Care Patients, Lori A. Constantine
Graduate Theses, Dissertations, and Problem Reports (ETD)
Body: Twenty percent of all Americans die in an intensive care unit (ICU) or shortly thereafter. For most of these patients, relentless and distressing symptoms are commonplace. Review of local data reveals opportunity for improvement in the palliative care offered to hospitalized patients. To address this need for improved palliative care, the Volunteer Hospital Association's (VHA) Communication and Care Bundle will be implemented in a local medical ICU, using Roger's (2003) diffusion of innovations (DOI) as the theoretical base.;Evaluation: Communication and Care Bundle within a given time frames, for select medical ICU patients. ICU length of stay and patient mortality …
Parents' Perspectives, Observations, And Interpretations Of: Cancer-Related Fatigue And How The Symptom Shapes Their Child's Day-To-Day Quality Of Life, Tina Antill Keener
Parents' Perspectives, Observations, And Interpretations Of: Cancer-Related Fatigue And How The Symptom Shapes Their Child's Day-To-Day Quality Of Life, Tina Antill Keener
Graduate Theses, Dissertations, and Problem Reports (ETD)
Fatigue is a common and distressing symptom of childhood cancer that is often viewed as an inevitable part of cancer treatment and under assessed in clinical practice. Yet, cancer-related fatigue can disrupt normal childhood development and family functioning, as well as, signal serious complications of cancer and its treatment. Little is known about fatigue and quality of life among children undergoing cancer treatment in outpatient settings. This qualitative descriptive study explored parents' observations and interpretations of cancer-related fatigue and how it shaped their child's day-to-day quality of life during cancer treatment. Eleven participant interviews were gathered from parents of children …
Implementation And Evaluation Of A Practice Change Incorporating A Weight Loss Strategy For Adolescent Patients With A Bmi Percentile In The Overweight And/Or Obese Category, Anita C. Fouch
Graduate Theses, Dissertations, and Problem Reports (ETD)
Background: Adolescent obesity has become an epidemic nationwide and globally. In Ohio, rates of obesity among African American, Hispanic and other minority students continues to rise. Adolescent obesity increases the risk of developing co-morbid health issues, such as Type II Diabetes Mellitus (T2DM), hypertension (HTN) and fatty liver disease.;Objective: To implement and evaluate a practice change incorporating a weight loss strategy in a large pediatric gastroenterology clinic for adolescent patients with a body mass index percentile (BMI) in the overweight and/or obese category.;Method: The capstone project practice change involved the use of a nosugaradded beverages weight loss strategy used by …
Evaluation Of The Effectiveness Of Healthy Me A Nutritional And Exercise Program For African American Adolescents In An Urban School Utilizing The Cope/Teen Program, Patricia D Setlow
Evaluation Of The Effectiveness Of Healthy Me A Nutritional And Exercise Program For African American Adolescents In An Urban School Utilizing The Cope/Teen Program, Patricia D Setlow
Graduate Theses, Dissertations, and Problem Reports (ETD)
Background.;Obesity, a preventable and reversible condition, increases the risk of type 2 diabetes, hypertension, and hyperlipidemia, while decreasing both life expectancy and quality of life (U.S. Department of Health And Human Services, 2001). The national obesity rate for adolescents ages 12-19 years was 18.1% in the 2007-2008 period, a significant change from 6.1% in the early 70's (CDC, 2009). According to Barlow (2007) these figures have sounded alarms for all involved in the health care of children and adolescents.;Objectives.;The purpose of this pilot program was to assess the effectiveness of providing nutritional education and exercise opportunities for African American adolescents …
Thrombospondin: An Emerging Keystone In Skeletal Muscle Structure And Function, Gerald Nelson Audet
Thrombospondin: An Emerging Keystone In Skeletal Muscle Structure And Function, Gerald Nelson Audet
Graduate Theses, Dissertations, and Problem Reports (ETD)
Our objective was to elucidate the effects of TSP-1 on skeletal muscle structure and function, and its potential role in the progression of skeletal muscle dysfunction. The central hypothesis was that TSP-1 is a critical negative regulator of skeletal muscle angiogenesis. In chapter 3, we used a TSP-1 mimetic delivered by mini osmotic pumps to show that TSP-1 can reduce capillarity across three distinct muscle types. We found that those given the mimetic had a 35% decrease in soleus capillarity, a 20% decrease in the gastrocnemius, and an 11% decrease in the plantaris. This confirmed the critical role that TSP-1 …
Examination Of Factors Associated With Obesity, Physical Activity And Income In Metropolitan Areas Of The United States, Ahadu T. Tekle
Examination Of Factors Associated With Obesity, Physical Activity And Income In Metropolitan Areas Of The United States, Ahadu T. Tekle
Graduate Theses, Dissertations, and Problem Reports (ETD)
The prevalence of obesity has increased significantly in the past three decades. Obesity and inadequate physical activity are the major contributors to health problems. In addition to understanding the contribution of biological and psychological factors in the growth of obesity rates, there is a growing interest in understanding the impact of environmental factors on obesity. This study examines the relationship between obesity, socioeconomic factors, environmental factors and physical activity. The study is focused on metropolitan areas and relied on metropolitan county level built environment, natural amenities and outdoor recreational opportunities measures. Individual level socioeconomic and location information is from the …
Effects Of A Gonadotropin Mixture On Reproductive Success In Progesterone- Treated Non-Lactating Anestrous Ewes, Kellie Nicole D'Souza
Effects Of A Gonadotropin Mixture On Reproductive Success In Progesterone- Treated Non-Lactating Anestrous Ewes, Kellie Nicole D'Souza
Graduate Theses, Dissertations, and Problem Reports (ETD)
Using exogenous gonadotropins as part of an estrous induction protocol can have beneficial effects on fertility in ewes bred out-of-season. Few studies have evaluated the efficacy of P.G. 600RTM, a mixture of gonadotropins with FSH-like and LH-like activity, to increase fertility in anestrous ewes and, in particular, following pre-treatment with progesterone delivered via controlled internal drug releasing (CIDR) devices. The objective of this study was to evaluate the effects of P.G. 600RTM on reproductive success in progesterone-treated non-lactating anestrous ewes. Ewes, which had been separated from rams for at least one month prior to the beginning of the experiment, received …
The Effect Of Melatonin Or Maternal Nutrient Restriction On Cell Proliferation In The Ovine Placenta, Adam Walter Eifert
The Effect Of Melatonin Or Maternal Nutrient Restriction On Cell Proliferation In The Ovine Placenta, Adam Walter Eifert
Graduate Theses, Dissertations, and Problem Reports (ETD)
Our objectives were to assess melatonin receptor dependent modulation of placental cell proliferation following treatment with either melatonin, luzindole (melatonin receptor 1 and 2 antagonist), or vehicle. In addition, a second study was conducted to assess placental cell proliferation following dietary melatonin treatment in a maternal nutrient restriction model. For the first experiment, 14 primiparous ewes were fitted with Alzet mini osmotic pumps attached to a catheter and infused with vehicle, melatonin, or luzindole from d 62 to 90 of gestation. Ewes were euthanized and placentomes collected for analysis at the end of the 4 week infusion. For the second …
Absorption Of Marine Vs Non-Marine Sources Of Epa And Dha, John S. Ketz
Absorption Of Marine Vs Non-Marine Sources Of Epa And Dha, John S. Ketz
Graduate Theses, Dissertations, and Problem Reports (ETD)
Docosahexaenoic acid (DHA) from algae oil has been incorporated into tissues at a lower level and has been less effective than fish oil (FO) at reducing body fat. Our objective was to determine fecal excretion of eicosapentaenoic acid (EPA) and DHA from different dietary sources. Male mice (n=100) were fed a 12% lipid diet containing soy oil (SO), FO, yeast oil (YO) algae oil (AO), or AO+YO. The AO diet was fed to contain amounts of DHA equal to the FO diet, and the YO diet was fed to contain amounts of EPA equal to the FO diet. To measure …
Evaluation Of Growth And Survival Of Hardwood Trees On Brown And Gray Sandstone, Lindsay M. Wilson-Kokes
Evaluation Of Growth And Survival Of Hardwood Trees On Brown And Gray Sandstone, Lindsay M. Wilson-Kokes
Graduate Theses, Dissertations, and Problem Reports (ETD)
Deciduous forests in the Appalachian region have been greatly disrupted due to surface coal mining since the 1930's. After the passage of the Surface Mining Control and Reclamation Act (SMCRA) in 1977, coal mine operators began planting a variety of grasses and legumes as a fast and economical way to re-establish a permanent vegetative cover in order to meet erosion and site stabilization requirements. However, soil compaction and competitive forage species have arrested the re-colonization of native hardwood tree species on these reclaimed sites. In an effort to evaluate tree growth on selected spoils and determine the effects of compaction, …
Is Postural Stability Compromised In Women With Urinary Incontinence?, Samantha K. Rondini
Is Postural Stability Compromised In Women With Urinary Incontinence?, Samantha K. Rondini
Graduate Theses, Dissertations, and Problem Reports (ETD)
Women with urinary incontinence (UI) have an increased risk of falling compared to their age-matched peers without UI. Due to the anatomical location of the pelvic floor muscles, they are suspected to contribute to the maintenance of postural stability during everyday activities. Women with UI have weak or dysfunctional pelvic floor muscles. The purpose of this study was to determine if women with UI, specifically stress, urge, and mixed UI, have deficits in postural stability during static tasks and in response to postural perturbations of the support surface.;Methods: To measure static stability, 14 women (7 with UI: age 51.75 +/- …
Characterization Of Genes Involved In Sumoylation During Embryogenesis In Rainbow Trout (Oncorhynchus Mykiss), Xiaowei Zang
Characterization Of Genes Involved In Sumoylation During Embryogenesis In Rainbow Trout (Oncorhynchus Mykiss), Xiaowei Zang
Graduate Theses, Dissertations, and Problem Reports (ETD)
SUMOylation is the post-translational modification of proteins by the addition of the small ubiquitin-like modifier (SUMO), which plays an important role in various cellular processes. It has been reported that SUMO and its related proteins are important in diverse reproductive functions such as ovulation, gametogenesis, and embryogenesis. Modification of target proteins by SUMO is an ATP-dependent enzymatic cascade involving three key enzymes: E1 activating enzyme (the heterodimer SAE1-SAE2), E2 conjugating enzyme (UBC9) and several E3 ligating enzymes (PIAS, RanBP2/Nup358 and Pc2). The objectives of this study were to characterize the genes involved in SUMOylation and determine their expression profiles during …
An Evaluation Of The Idaho Plate Method For Adults With Type 2 Diabetes And Limited Health Literacy In Rural West Virginia, Pamela L. Edens
An Evaluation Of The Idaho Plate Method For Adults With Type 2 Diabetes And Limited Health Literacy In Rural West Virginia, Pamela L. Edens
Graduate Theses, Dissertations, and Problem Reports (ETD)
This capstone project evaluated the Idaho Plate Method (IPM) as an effective nutrition self-management program for adults with type 2 diabetes mellitus (T2DM) with limited health literacy (LHL) in one rural clinic in West Virginia. A one-way pretest-posttest design was used to evaluate the effects of the program on food choices, confidence, and HbA1c. A convenience sample of 30 volunteers participated in the program with 3-month follow-up data collected on 22 volunteers. A Wilcoxon test was conducted to evaluate choices of fruits, vegetables, and fatty foods and participant confidence in making healthful food choices. Data analysis found significant differences in …
The Streptococcal Collagen-Like Protein-1 (Scl1) Is A Multifunctional Adhesin In Extracellular Matrix Interactions, Biofilm Formation, And Host Colonization By Group A Streptococcus, Heaven A. Oliver-Kozup
The Streptococcal Collagen-Like Protein-1 (Scl1) Is A Multifunctional Adhesin In Extracellular Matrix Interactions, Biofilm Formation, And Host Colonization By Group A Streptococcus, Heaven A. Oliver-Kozup
Graduate Theses, Dissertations, and Problem Reports (ETD)
Group A Streptococcus (GAS) is responsible for over 100 million skin infections annually that may lead to invasive episodes and autoimmune sequelaes. Wounds and unapparent skin infringements are susceptible to the introduction of GAS and serve as a portal of entry. The nutritional nature of a wound and the accessibility to exposed host cell surfaces and extracellular matrix components create a model milieu for successful host colonization and potential biofilm formation. The initiation of biofilm is often mediated by bacterial surface adhesins and has been shown to interfere with wound healing by blocking critical host cellular interactions. However, the underlying …
Differences In Early Childhood Environmental Rating Scale Scores In Collaborative And Non-Collaborative West Virginia Pre-K Classrooms Located In Child Care Facilities, Jessica S. Day
Graduate Theses, Dissertations, and Problem Reports (ETD)
Quality of pre-k collaborative and non-collaborative classrooms was investigated for differences in environmental quality between the two types of classrooms. Data was collected through the West Virginia Department of Health and Human Resources grant titled, "Quality Rating and Improvement for West Virginia Child Care." Quality was measured using the Early Childhood Environmental Rating Scale-Revised (ECERS-R), which has 43 items across seven subscales: Space and Furnishings, Personal Care Routines, Language-Reasoning, Activities, Interaction, Program Structure, and Parents and Staff. Thirty-six pre-k collaborative programs participated and 136 non-collaborative programs participated in the study. Non-collaborative pre-k classrooms had lower mean scores on all subscales …
Project Knowledge Of 4-H Members Who Participated In The Equine Skillathon At The West Virginia State Fair, Kolby Denae Wyant
Project Knowledge Of 4-H Members Who Participated In The Equine Skillathon At The West Virginia State Fair, Kolby Denae Wyant
Graduate Theses, Dissertations, and Problem Reports (ETD)
An Equine Skillathon is conducted annually at the West Virginia State Fair in Department F that is open to 4-H and FFA members. At the 2012 West Virginia State Fair, a descriptive research study was done utilizing the Equine Skillathon as the method of instrumentation. The study was conducted to assess the fundamental equine knowledge of junior and senior 4-H members who participated in the 2012 State Fair Equine Skillathon in the five categories of breed identification, conformation, body and hoof parts, as well as feed identification. The data was collected from the participating 4-H members' score sheets and used …
Mechanisms Of Cadmium Tolerance In Populus, Brahma Reddy Induri
Mechanisms Of Cadmium Tolerance In Populus, Brahma Reddy Induri
Graduate Theses, Dissertations, and Problem Reports (ETD)
Cadmium (Cd), a known carcinogen and one of the leading heavy metal pollutants on a global scale, is released to the atmosphere through various industrial processes such as smelting and mining and other applications including manufacture of batteries and phosphate fertilizers. It causes many deleterious effects in plants, and is harmful to humans through its entry into the food chain. Traditional methods of remediating Cd-contaminated soils, such as excavation and land-filling, are expensive and disturb the natural topography. The emerging method of phytoremediation in which plants are employed to remediate contaminated soils has become increasingly popular because of its cost …
Knowledge And Awareness Of Sickle Cell Trait Among Ncaa Division I Fbs, Division I Fcs, Division Ii, And Division Iii Head Football Coaches And Strength And Conditioning Specialists, Timothy D. Yates
Graduate Theses, Dissertations, and Problem Reports (ETD)
Objective: The purpose of this study is to examine the knowledge of Sickle Cell Trait among head football coaches and strength and conditioning specialists within all three NCAA Divisions. Additionally, a second purpose is to identify whether or not head football coaches and strength and conditioning specialists present awareness and confidence to provide the proper treatment and/or referral for an athlete suffering from an exercise-related event due to Sickle Cell Trait. Design: This study is a descriptive prospective questionnaire analysis of the knowledge and awareness of Sickle Cell Trait among collegiate head football coaches and strength and conditioning specialists. Results: …
Evaluation Of The Effectiveness Of The International Index Of Erectile Function (Iief-5) (Shim) Questionnaire On The Diagnosis And Treatment Of Erectile Dysfunction, Evelyn Martin
Graduate Theses, Dissertations, and Problem Reports (ETD)
Thirty million or 52% of males between 40 and 70 years of age in the United States have some degree of erectile dysfunction (ED) (Feldman et al., 1994; Hakim, Subit, Kandzari, & ZasLau, 2002; Tsertsvadze et al., 2009). The American Urology Association (AUA) outlines measures to slow the rate of, control, and treat ED. To decrease the prevalence, ED must be diagnosed, identified, and the major risk factors aggressively controlled. Utilization of clinical practice guidelines (CPGs) may improve identification and documentation of treatment, but questions remain about how to implement CPGs in practice. The purpose of this pilot project was …
The Effect Of Non-Marine Vs. Marine Sources Of The Omega-3 Fatty Acids, Dha And Epa, On Serum Lipoproteins, Mary C. Rodavich
The Effect Of Non-Marine Vs. Marine Sources Of The Omega-3 Fatty Acids, Dha And Epa, On Serum Lipoproteins, Mary C. Rodavich
Graduate Theses, Dissertations, and Problem Reports (ETD)
Background: Fish oil (FO) is a marine source of n-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexanaenoic acid (DHA), and has been shown to improve heart health.;Objective: The purpose of this study was to determine the cardiovascular effects of non-marine sources of n-3 fatty acids, algae oil (AO) and yeast oil (YO), as compared to fish oil (FO).;Methods: Male ICR mice (8 wk old, n=100) were randomly assigned to dietary treatment groups: soy oil (SO; 0 g/kg DHA or EPA), FO (7.03 g/kg DHA + 12.64 g/kg EPA), AO (7.03 g/kg DHA + 0.13 g/kg EPA), YO (0.018 g/kg DHA …
The Effects Of Feeding Growing Female Rats Different Sources Of Omega-3 Polyunsaturated Fatty Acids On Lipogenic Gene Expression And Lipid Metabolism In Liver And Adipose Tissues, Kaitlin Mock
Graduate Theses, Dissertations, and Problem Reports (ETD)
Omega-3 polyunsaturated fatty acid (n-3 PUFA) consumption has increased through diet and supplementation due to reports of health benefits. The objective of this study was to determine whether different n-3 PUFA sources play a role in lipid metabolism by altering lipogenic gene expression, serum lipids and lipoproteins, and inflammation. Young (aged 28 days) female Sprague-Dawley rats were assigned to one of six diets: corn oil (CO, control), flaxseed oil (FO), krill oil (KO), menhaden oil (MO), salmon oil (SO), or tuna oil (TO). qPCR was used to analyze relative gene expression. Only MO-fed rats had down-regulated gene expression of the …
Characterization Of Coconut Oil And Cla Induced Lipolysis, Siri Manasa Ippagunta
Characterization Of Coconut Oil And Cla Induced Lipolysis, Siri Manasa Ippagunta
Graduate Theses, Dissertations, and Problem Reports (ETD)
Obesity is a main health concern and leads to many other health complications. Conjugated linoleic acid (CLA) has been shown to cause a reduction in obesity in several species. CLAinduced body fat loss is enhanced when mice are fed coconut oil (CO). The objectives were to determine if the CLA-induced lipolysis in different oil source-fed mice was time-dependent and to determine the effect of cell signaling inhibitors on CO+CLA-induced lipolysis. Study 1: Male mice (ICR; n=80; 3wk) were fed 7% soybean oil (SO) or CO diets for 6wk and then supplemented with 0 or 0.5% CLA for 3, 7, 10 …
The Effect Of Organic Acids On Compositional Characteristic Of Protein And Lipid Recovered During Isoelectric Solubilization/Precipitation Processing Of Silver Carp And The Effectiveness Of These Organic Acids On The Reduction Of Staphylococcus Aureus, Maryam Ronaghi
Graduate Theses, Dissertations, and Problem Reports (ETD)
An effective method to recover protein, called ISP processing, uses extreme pH shifts to solubilize protein and then recover it by precipitation and centrifugation. The objective of this study was to determine the proximate composition of the recovered materials from ISP after processing with different acid concentrations and the bactericidal effectiveness of these acids in comparison with hydrochloric acid (HCl) and acetic acid against Staphylococcus aureus during isoelectric solubilization and precipitation (ISP) processing. Headed and gutted silver carp were homogenized and brought to the protein solubilization pH (2.5, 3.0, 11.5, or 12.5) using the acids (glacial L-lactic acid and formic …
Spatial Relationship Between The Trichloroethylene Degrading Bacteria Dehalococcoides Sp., Sulfate Reducers And Archaea During Reductive Dechlorination, Pujya Wagle Gautam
Spatial Relationship Between The Trichloroethylene Degrading Bacteria Dehalococcoides Sp., Sulfate Reducers And Archaea During Reductive Dechlorination, Pujya Wagle Gautam
Graduate Theses, Dissertations, and Problem Reports (ETD)
Trichloroethylene (TCE) released to the environment is of great concern due to its toxicity and carcinogencity. The microorganisms involved in bioremediation of TCE such as methanogens (organisms within the domain Archaea), sulfate reducing bacteria (SRB) and Dehalococcoides sp. (DHC) are of particular interest in this study. Three different types of bench scale reactors were constructed to model different aquifer types such as sandy, silty and fractured bedrock aquifers (hereafter type 1, 2 or 3 reactors, respectively). This study evaluated the effect of TCE concentration in different types of reactors on the distribution of selected microorganisms with distance from the source …
Skeletal Muscle Regeneration And The Role Of Sirtuin 1, Brian T. Bennett
Skeletal Muscle Regeneration And The Role Of Sirtuin 1, Brian T. Bennett
Graduate Theses, Dissertations, and Problem Reports (ETD)
The main objective of this master's thesis project was to elucidate the role of the deacetylase Sirtuin 1 (Sirt1) in skeletal muscle regeneration. We developed two specific aims to accomplish this task, which involved separate studies in order to study the effects of Sirt1 in multiple models of regeneration. The results from these studies may potentially lead to the development of novel therapies to treat various clinical conditions which require muscle regeneration.;Specific aim 1 utilized resveratrol, a Sirt1 activator, as a supplement to improve muscle regeneration following a period of disuse in aged animals. Aged Fisher 344 x Brown Norway …
An Examination Of Non-Exercise Activity Thermogenesis In Rural Youth, Molly R. Matthews-Ewald
An Examination Of Non-Exercise Activity Thermogenesis In Rural Youth, Molly R. Matthews-Ewald
Graduate Theses, Dissertations, and Problem Reports (ETD)
Weight gain among United States' children, adolescents and adults has become a pandemic problem, and is of great public health concern, given the increased risk for myriad chronic health problems and associated medical expenditures. It is well established that increased energy expenditure through physical activity may reduce weight and improve health. However, the predominant focus of this research has been with moderate to vigorous levels of activity (MVPA). A growing body of evidence suggests that activity levels below this (i.e., light levels), may also be beneficial. Specific to light activity, a recent area of focus has been on non-exercise activity …