Digital Commons Network^™

A Program Evaluation Of The West Virginia University Health Science Center Interprofessional Education First-Year Curriculum, Kathryn Lynn Smalley

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: The Interprofessional Education (IPE) First-Year Program was started at the West Virginia University Health Sciences Center in 2013 with the goal of providing participants introductory knowledge of the IPE Core Competencies as defined by the Interprofessional Education Collaborative (IPEC). This program transfers 16 different disciplines out of their isolated educational silos and allows them to learn about, for, and with one another. Participants are introduced to foundational knowledge through several didactic sessions over the course of an academic year. Although the program has been increasingly incorporated by many health sciences disciplines since its inception, it has never officially …

Cell Signaling And Stress Response In The Yeast Saccharomyces Cerevisiae: A Study Of Snf1, Scott E. Arbet Ii

Graduate Theses, Dissertations, and Problem Reports (ETD)

Saccharomyces cerevisiae are yeast that are unicellular eukaryotic organisms that are well studied as a model organism for understanding fundamental cellular processes. The ability of yeast to sense nutrient availability is crucial for their survival, growth, and reproduction. Yeast cells use various mechanisms to sense and respond to nutrient availability, including transporter-mediated uptake, receptor-mediated signaling, and sensing of metabolites. The subcellular localization of nutrient-sensing components is crucial for yeast function in nutrient sensing and signaling. Protein complexes, such as the AMP-activated protein kinase (AMPK) pathway, in nutrient sensing and response, as well as the downstream effects of these pathways …

Businesses Supposedly Held The Key To The Ada, But They Dropped The Ball: Can Marketing Be The Shot In The Arm America Needs To Bring The Spirit Of The Ada Back To Life?, Elizabeth T. Gratz

Graduate Theses, Dissertations, and Problem Reports (ETD)

This research investigates the historical and current focus of the field of marketing on the disability community and considers whether marketers can positively impact attitudes toward the group through their firm media content. My first essay uses the Rocky Road to Policy Pavers model to discuss the importance of this large and underserved consumer group, and highlights several opportunities for the marketing community to reduce existing barriers to disabled consumers in the marketplace. One way that marketers can reduce stigma and improve attitudes toward the disability community is by strategically portraying individuals with disabilities in their firm media content. My …

Elucidation Of The Role Of Agouti-Signaling Protein Throughout Folliculogenesis And Early Embryonic Development In Cattle, Heather L. Chaney

Graduate Theses, Dissertations, and Problem Reports (ETD)

The oocyte expresses certain genes during folliculogenesis to regulate the acquisition of oocyte competence. Oocyte competence, which refers to the presence of imperative molecular factors in the oocyte that are critical for high oocyte quality, is directly related to the ability of the oocyte to result in a successful pregnancy following fertilization. Over the past few decades, the development and optimization of assisted reproductive technologies, particularly in vitrofertilization, have enabled the beef and dairy industries to advance cattle genetics and productivity. However, only approximately 40% of bovine embryos will develop to the blastocyst stage in vitro. In addition, bovine embryos …

A Neo-Aristotelian Criticism Of Trump’S “Save America Speech” Utilizing The Five Canons Of Rhetoric, Jade Ruggieri

Graduate Theses, Dissertations, and Problem Reports (ETD)

Riddled with fake news, the 2020 election is a unique moment in history where fake news, stemming from former President Donald Trump, led to a public demonstration that quickly devolved into a violent and controversial event. Through the lens of a Neo-Aristotelian rhetorical criticism, the five canons of rhetoric will analyze Trump’s “Save America” speech he held hours prior to the rally providing insights into how the power of words can precipitate people to incite action. Through a verbatim examination of the first and last 10 minutes of the speech, with the middle portion summarized, Trump’s speech provides insights to …

Gender Inclusivity In Italian: Can Gender Neutrality Be Reached In A Gendered Language? Difficulties, Proposals And Public Perception Of The Phenomenon, Gaia Prunotto

Graduate Theses, Dissertations, and Problem Reports (ETD)

Italian is a gendered language in which reference to grammatical gender has been constant and inevitable. As language reflects and shapes society, grammatical gender reinforces binary views of social gender and the invizibilization of non-binary identities. Movements for social justice have inspired gender-fair linguistic innovations, such as the feminization of job titles and gender-neutral markers, to promote gender equity and challenge hierarchies of power and dominance in society. This research aimed to explore gender-neutral forms in the Italian grammatical system and public perceptions of these innovations through two studies with two groups of participants.

The first group of participants (n=27) …

Intercultural Competence In The Esl Classroom: Challenges And Successes, Breno Santos Rodrigues Pereira

Graduate Theses, Dissertations, and Problem Reports (ETD)

This action-based research study investigated the challenges and successes involved in the teaching of intercultural competence in the English as a Second Language (ESL) classroom. Most studies on intercultural competence take place in English as a foreign language classroom, and very few are centered on ESL instruction. It is this gap in the research that motivated the present study, in which the following research questions were posed: 1) How do targeted training practices in the classroom promote the development of intercultural competence as demonstrated by quantitative data?; 2) What challenges are associated with teaching intercultural competence to ESL learners?; 3) …

How Do College Student-Athletes’ Understanding And Expectations Of Mindfulness And Self-Compassion Change Through An Intervention?, Blake Costalupes

Graduate Theses, Dissertations, and Problem Reports (ETD)

In the last two decades, mindfulness has permeated sport, exercise, and performance psychology (SEPP). Mindfulness research in SEPP primarily focuses on the efficacy of manualized protocols on various outcomes related to performance and wellbeing; how athletes understand this complex construct, though, is largely unexplored in the literature. Additionally, some researchers suggest that the potentially paradoxical adoption of mindfulness in Western psychology may be contributing to limited outcomes, low engagement in, and poor adherence to mindfulness-based interventions (MBIs). In addition, the exploration of self-compassion as a mechanism for change through mindfulness practice has increased in recent years, making it an important …

Giving Power To Corporate Social Responsibility: A Case Study Of The Organization-Public Relationship Between A Public Utility And Its Community Stakeholders, Rhyanna C. Wiethe

Graduate Theses, Dissertations, and Problem Reports (ETD)

The purpose of this research is to examine how, if at all, relationships between public utility companies and their stakeholders changes following a corporate social responsibility (CSR) initiative, and based on the results, how can companies restructure their initiatives to better serve their publics in order to build stronger, more positive relationships. A multi-method case study using in-depth interviews and two content analyses (a social media analysis and a news coverage analysis) was used to explore the relationship between a public utility company and a community affected by the implementation of a CSR initiative. The findings suggest that the relationship …

Visual Sensing For Comprehensive Granular Traffic Data Collection In Support Of Intelligent Transportation Applications, Linjun Lu

Graduate Theses, Dissertations, and Problem Reports (ETD)

Comprehensive granular traffic data collection has been identified as one of the most essential tasks in the development of intelligent transportation systems (ITS). With the recent advances in electro-optical sensors and computational capacities, machine vision is regarded as cost-efficient for traffic data collection. However, the existing vision-based methods are only applicable for collecting limited types of traffic data, and a unified method allowing for comprehensive traffic data collection is still missing in the existing literature. Moreover, there are still challenges that exist for the use of the existing vision-based methods in real settings, including low accuracy and compromised applicability due …

Examining The Use Of Social Media Applications By West Virginia Agriculture Producers, Mikayla Rae Hargis

Graduate Theses, Dissertations, and Problem Reports (ETD)

Social media has become part of the typical individual’s everyday routine, with no exception to those in the agricultural industry. The purpose of this study was to examine social media usage by West Virginia agricultural producers. The population for this study consisted of agricultural producers in West Virginia. The study yielded 44 responses from those who attended the 2022 West Virginia Farm Bureau meeting. An explanatory sequential design methodology was employed for this study. After the initial quantitative phase, a qualitative phase was conducted with producers who use social media in their operations. Based on the results, there is much …

Il-27 Negatively Impacts Immunity Developed Following Bcg Administration, Shelby D. Bradford

Graduate Theses, Dissertations, and Problem Reports (ETD)

Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis (TB), a predominantly respiratory pathogen responsible for over ten million infections and one million deaths last year. Despite it being a primary objective of the World Health Organization (WHO) for several decades to irradicate TB, progress toward this objective has fallen short of the 2020 target to end TB by 2035. Meeting this goal will require advancements in diagnostic tools, education, healthcare access, and treatments and preventatives. Regarding prevention, the primary tool for this strategy is through vaccination. Currently, the only licensed vaccine for protection against TB is the century old …

An Assessment Of The Forensic Aspects Of Genetic Genealogy, Sarah Hester

Graduate Theses, Dissertations, and Problem Reports (ETD)

Forensic genetic genealogy has grown in both popularity and controversy in recent years. The genetic information comes from large numbers of single nucleotide polymorphism (SNP) markers. Polymorphism variations can be traced through familial lineage, determining how closely individuals are related to each other based on the similarities and differences in SNPs within their DNA. Polymorphisms account for approximately 85% of human variation. Genealogy and ancestry determination companies trace the lineage of a person back through multiple generations using polymorphisms. As more individuals submit their DNA for analysis the genealogical profile databases continue to grow in size. Law enforcement uses genealogical …

The Investigation Of Novel Bovine Oocyte-Specific Long Non-Coding Rnas And Their Roles In Oocyte Maturation And Early Embryonic Development, Jaelyn Zoe Current

Graduate Theses, Dissertations, and Problem Reports (ETD)

Early embryonic loss is a significant factor in livestock species' infertility, resulting in an economic deficit. In cattle, the in vivo fertilization rate is ~90%, with an average calving rate of about 55%, indicating an embryonic-fetal mortality rate of roughly 35%. Further, 70-80% of total embryonic loss in cattle occurs during the first three weeks after insemination, particularly between days 7-16. Growing evidence indicates that the oocyte plays an active role in regulating critical aspects of the reproductive process required for successful fertilization, embryo development, and pregnancy. However, defining oocyte quality remains enigmatic. Recently, many have abandoned the notion that …

Composers At War: A Study Of Composers Who Fought In World War I And World War Ii, Jason T. Hoffmann

Graduate Theses, Dissertations, and Problem Reports (ETD)

This research document explores the connections between the war experiences of four composers and whether the possibility existed that any of the composers had posttraumatic stress disorder (PTSD), moral injury, mild traumatic brain injuries (mTBI), traumatic brain injury (TBI) or chronic traumatic encephalopathy (CTE). Scholars have not thoroughly examined the music of composers written before, during, and after war experiences and any potential changes to musical styles or compositional techniques. In my research I look at the effects that war can have on composers through autobiographical and biographical accounts of Ivor Gurney (WWI), Olivier Messiaen (WWII), Maurice Ravel (WWI), and …

What Gives? Leveraging Marketing Knowledge To Increase Consumers’ Charitable Giving, Caitlin Michael

Graduate Theses, Dissertations, and Problem Reports (ETD)

Marketing plays a central role in nonprofit organizations that compete for the donations of individual consumers to achieve their respective missions. To this end, marketing researchers and practitioners have devoted much attention to the antecedents of charitable giving and ways in which solicitations may be made more effective and efficient. This gives rise to the questions: “What has the field learned?” and, relatedly, “What novel effects have not yet been explored?” Within this dissertation, three essays address these questions through the use of multiple methodologies.

The first essay seeks to outline what the marketing field has learned about consumers’ charitable …

Localization Of People In Gnss-Denied Environments Using Neural-Inertial Prediction And Kalman Filter Correction, Lauren N. Cash

Graduate Theses, Dissertations, and Problem Reports (ETD)

This thesis presents a method based on neural networks and Kalman filters for estimating the position of a person carrying a mobile device (i.e., cell phone or tablet) that can communicate with static UWB sensors or is carried in an environment with known landmark positions. This device is used to collect and share inertial measurement unit (IMU) information — which includes data from sensors such as accelerometers, gyroscopes, and magnetometers — and UWB and landmark information. The collected data, in combination with other necessary initial condition information, is input into a pre-trained deep neural network (DNN) which predicts the movement …

Gut-Lung Axis Of The Microbiome Alterations After Ultrafine Particles And Ozone Inhalation, Md Habibul Hasan Mazumder

Graduate Theses, Dissertations, and Problem Reports (ETD)

Air pollution poses a significant threat to public health. It is a mixture of particulate matter, gaseous substances, and other secondary substances. Despite epidemiological research indicating the interactive effects of various components of air pollution, existing studies and regulatory limits often focus on single-exposure scenarios. The emerging understanding of the microbiome’s role in regulating immune response, metabolism, and pathophysiology of various diseases points towards interactions between environmental exposures and microbial dysbiosis. In this dissertation, mice were exposed to relevant deposited doses of carbon black (CB) and ozone (O3), and lung inflammation as well as the lung-gut axis of the microbiome …

Application Of Computational Biophysics Techniques To Characterize Cell Membrane-Associated Events, Kyle Billings

Graduate Theses, Dissertations, and Problem Reports (ETD)

Cell membranes are crowded environments which can modulate protein structure-function relationships through interaction with lipids, other proteins, carbohydrate structures and so on. This work focuses the impact of the membrane environment on two varieties of peptides: Microbial rhodopsin proteins, and cyclic peptides.

Life on Earth is dependent on the ability of plants and microbes to harness sunlight for energy production. Their ability to transform light into carbohydrates requires tailor-made machinery, and for a wealth of microorganisms, microbial rhodopsin proteins (MR) are critical for maintaining the concentration gradients used to produce the energy molecule Adenosine triphosphate (ATP). The central retinal molecule …

Exploiting The Advantages And Overcoming The Challenges Of The Cable In A Tethered Drone System, Rogerio Rodrigues Lima

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation proposes solutions for motion planning, localization, and landing of tethered drones using only tether variables. A tether-based multi-model localization framework for tethered drones is proposed. This framework comprises three independent localization strategies based on a different model. The first strategy uses simple trigonometric relations assuming that the tether is taut; the second method relies on a set of catenary equations for the slack tether case; the third estimator is a neural network-based predictor that can cover different tether shapes. Multi-layer perceptron networks previously trained with a dataset comprised of the tether variables (i.e., length, tether angles on the …

Examining The Relations Among Academic And Non-Cognitive Factors And Student Achievement, Dona Sachini Hasanjalie Hewagallage

Graduate Theses, Dissertations, and Problem Reports (ETD)

Since the 1980s, Physics Education Research (PER) has explored the factors influencing students' success in college. This manuscript reports three different studies to understand the impact of different factors on students' college physics achievement. The first study explored several academic (high school physics preparation, high school preparation, math readiness, and ACT or SAT verbal and mathematics scores) and non-cognitive (self-efficacy, personality, belonging, grade expectation, and demographic) factors using correlation and linear regression analysis to understand their relation to students' physics conceptual understanding measured by the Force and Motion Conceptual Evaluation (FMCE). High school preparation was found to be the most …

Investigating The Interactions Of The Iron-Sulfur Mitochondrial Protein, Mitoneet With Its Binding Partners, Ebenezer Osei Newton

Graduate Theses, Dissertations, and Problem Reports (ETD)

MitoNEET belongs to the CDGSH Iron-Sulfur Domain (CISD)-gene family of proteins and is a [2Fe-2S] cluster-containing protein found on the outer membrane of mitochondria. The specific functions of mitoNEET/CISD1 remain to be fully elucidated, but the protein is involved in regulating mitochondrial bioenergetics in several metabolic diseases. Unfortunately, drug discovery efforts targeting mitoNEET to improve metabolic disorders are hampered by the lack of ligand-binding assays for this mitochondrial protein. We have developed a protocol amenable for high-throughput screening (HTS) assay, by modifying an ATP fluorescence polarization method to facilitate drug discovery targeting mitoNEET. Based on our observation that adenosine triphosphate …

Relationships Among Racism, Dental Care-Related Fear/Anxiety And Dental Care Utilization Among Black And African American Women In Appalachia, Kalo Sokoto

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation is a study of the implications of racism in oral health care settings for dental care-related fear/anxiety, and dental care utilization. One in five adults in the US have experienced discrimination while receiving health care. Even though racism is the most reported type of discrimination in health care, little is known about its impact on dental outcomes. There is a paucity of prior studies measuring experiences of racism in dental settings. The current study proposed the application of Krieger’s Ecosocial Theory of Health Equity to explore relationships among racism in oral health care settings, dental care-related fear/anxiety, and …

Measuring And Modeling How Plant-Microbe Interactions Control Soil Carbon And Nitrogen Cycling In Managed And Unmanaged Ecosystems, Joanna Ridgeway

Graduate Theses, Dissertations, and Problem Reports (ETD)

Our understanding of how plant-microbe interactions regulate carbon (C) and nitrogen (N) retention in soil organic matter (SOM) remains uncertain. Conflicting evidence suggests that microbial decomposition can lead to the loss of unprotected particulate SOM, but also that microbial decomposition produces simpler compounds that preferentially form more persistent aggregate- or mineral-protected SOM pools. Further, uncertainty remains in how plant-microbe interactions alter SOM retention in these different pools through litter chemistry controls on microbial decomposition traits and rhizosphere priming. As a result, this uncertainty limits our ability to sustainably manage ecosystems and understand future feedbacks between terrestrial ecosystems and the global …

Xanthine Oxidase-Induced Vascular Dysfunction In Nano-Tio2 Inhalation, Xena Marie Williams

Graduate Theses, Dissertations, and Problem Reports (ETD)

Inhalation of nano-TiO₂ is linked to adverse clinical outcomes that affect people worldwide, particularly those who work in manufacturing. For example, cardiovascular consequences and changes in microvascular responses are, in part, associated with exposure to engineered nanomaterials such as nano-TiO₂; however, the mechanism(s) driving this process is unknown. Nano-TiO₂ is an engineered nanomaterial (ENM) that is reported to, upon inhalation, impair endothelium-dependent vasodilation in several vascular beds via enhanced local oxidant generation and diminished nitric oxide bioavailability. This dissertation aims to address the health concerns generated by occupational exposure to nano-TiO₂ and identify a link …

Quantifying The Impacts Of Genetically Engineered Crops And Deep Soil C Cycling On The Sustainability Of Bioenergy Crop Production, Zoe Pagliaro

Graduate Theses, Dissertations, and Problem Reports (ETD)

Bioenergy can help mitigate climate change by providing a carbon-neutral fuel source. However, multiple challenges exist to achieving carbon neutrality including converting lignocellulosic materials to fuel and enhancing soil C sequestration during the growth of the feedstocks. To address these challenges, there have been recent efforts to genetically modify feedstocks to produce more energy dense oils that increase fuel conversion efficiency and to cultivate deep-rooted perennial feedstocks that can enhance soil C storage. However, the C consequences and efficacy of these solutions remain largely uncertain.

To examine the C consequences of enhancing oil content of bioenergy feedstocks, I examined the …

How Do Higher Education Teaching And Learning Centers Contribute To An Institutional Culture Of Assessment?, Tracey Jean Beckley

Graduate Theses, Dissertations, and Problem Reports (ETD)

Teaching and learning centers in higher education are often charged with providing faculty development programming in support of overarching institutional goals related to effective teaching and assessment of student learning. Using the theoretical frameworks of Maki and Weiner as a launch pad, this exploratory case study examines how two teaching and learning centers have provided services, implemented programming, and strategically affected cultural change among faculty and other stakeholders in support of an institutional culture of assessment. The study revealed four thematic strands to consider when developing practical ways for teaching and learning centers to contribute to a culture-building endeavor in …

Characterization Of Two Krab-Containing Zinc Finger Transcription Factors In Bovine Preimplantation Embryonic Development, Mingxiang Zhang

Graduate Theses, Dissertations, and Problem Reports (ETD)

Oocyte developmental competence or oocyte intrinsic quality describes the capability of oocytes to resume meiosis, cleave and develop to blastocyst stage after fertilization, implant and develop to term in a good health. A growing number of evidences indicate that the majority of embryonic mortality occurs during early embryonic development in different species, including human, horse and cattle primarily due to poor oocyte quality. Maternal effect genes are key aspects of oocyte quality, which are transcribed during the process of oogenesis and folliculogenesis. The maternal factors are accumulated in oocytes, orchestrating various early developmental events including fertilization, epigenetic reprogramming and zygotic …

Narrative Inquiry Of Early Career Teachers’ Experiences Teaching During The Covid-19 Pandemic, Kinsey Ann Wright

Graduate Theses, Dissertations, and Problem Reports (ETD)

This study utilized narrative inquiry to learn the stories of early career teachers of students with disabilities as they navigated teaching during a global pandemic. Five early career teachers participated in a series of three semi-structured virtual interviews. Interviews were transcribed then analyzed using a six-phase approach to thematic analysis (Braun & Clarke, 2006). Nine themes were identified: Teaching, Communication, Parents, Special Education, Workload, Resources, Training and professional development, job satisfaction, and teacher preparation. Themes were organized and presented to answer the research questions of the study. The findings contribute to understanding pandemic-related challenges faced by early career teachers of …

Similitude, Scaling, And Prediction Of Stream Dissolved Oxygen Across The Contiguous U.S., Aron Gebreslase

Graduate Theses, Dissertations, and Problem Reports (ETD)

Dissolved oxygen (DO) is a general indicator of stream water quality and ecosystem health. However, the concentration of in-stream DO is controlled by various climatic, land use/cover, hydrologic, biochemical, and ecological drivers. Observational data for stream DO are often unavailable at the desired temporal and spatial scales. Accurate and reliable prediction of stream DO concentration based on a small set of environmental drivers is important to guide the water managers and policymakers to achieve and maintain healthy streams. This dissertation focused on identifying the dominant controls of stream DO and understanding the mechanisms and environmental regimes by employing machine learning, …