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Artificial Light At Night Disrupts Pain Behavior And Cerebrovascular Structure In Mice, Jacob Raymond Bumgarner

Graduate Theses, Dissertations, and Problem Reports (ETD)

Artificial Light at Night Disrupts Pain Behavior and Cerebrovascular Structure in Mice

Jacob R. Bumgarner

Circadian rhythms are intrinsic biological processes that fluctuate in function with a period of approximately 24 hours. These rhythms are precisely synchronized to the 24- hour day of the Earth by external rhythmic signaling cues. Solar light-dark cycles are the most potent environmental signaling cue for terrestrial organisms to align internal rhythms with the external day. Proper alignment and synchrony of internal circadian rhythms with external environmental rhythms are essential for health and optimal biological function.

The modern human environment on Earth is no longer …

Investigating The Effects Of Flotation Restricted Environment Stimulation Therapy On Neural Networks In Chronic Pain Patients Via Functional Magnetic Resonance Imaging And Other Modalities, Tyler Austin Mcgaughey

Graduate Theses, Dissertations, and Problem Reports (ETD)

Chronic lower back pain (CLBP) is one of the leading causes of disability worldwide, with an estimated direct cost of over 600 billion dollars in the US alone. CLBP profoundly impacts the patient, their support team, and the healthcare system. Widespread changes to the patient's well-being, including mental health, are seen in CLBP and contribute to a downward spiral that often leads to disability. Chronic pain is poorly understood and is difficult to treat because of its subjective nature. Recent improvements in pain assessment in the clinic and in biomedical research have had a profoundly impacted the field. More than …

The Transmission Of Saga At West Virginia University, James Froemel

Graduate Theses, Dissertations, and Problem Reports (ETD)

Changes in the higher education landscape continue to bring new regulations which enforce standardization and similarities in organizational behavior. Because of these pressures, institutional identities and differentiations are more dependent on the unique way students experience an institution rather than the structure of the organization. Through focus groups and interviews, this phenomenological study seeks to understand the ways in which the traditional undergraduate experience impacts the transmission of organizational saga at West Virginia University. To do so, it examines stories told by students through thematic analysis to connect student experiences with symbols of the university. Focusing on these connections and …

Empowering Elderpreneurs Scommerce For Genx Consignment Store Owners In West Virginia, Joyita Sarkar

Graduate Theses, Dissertations, and Problem Reports (ETD)

In an ever-evolving digital landscape, this research explores Generation X (GenX) consignment store owners in West Virginia and the transformative power of Social commerce (sCommerce). Despite the ubiquity of Social media platforms, little attention has been given to the impact of sCommerce on the consignment store industry. Drawing from the Technology Acceptance Model (TAM) and the Diffusion of Innovation Theory (DIT), this study examines the factors influencing sCommerce adoption decisions for GenX consignment store owners.

Through qualitative research, this study uncovers untold stories within this entrepreneurial landscape. Purposeful sampling of 11 women and 20-60 minutes of in-depth interviews reveal the …

Not A Do-Or-Die Affair: Freelance Journalists In Nigeria And Ethical Dilemmas, Tolulope O. Olasoji

Graduate Theses, Dissertations, and Problem Reports (ETD)

This study explores the ethical dilemmas Nigerian freelance journalists face and their implications for their work. It will use in-depth interviews with select freelance journalists. Several studies have established that ethical concerns are rife in—and indeed the bane of—journalism in Nigeria. However, these pieces of research reflect the reality across conventional newsrooms, where, ideally, there is some organizational structure and support. No scholarly attention has been given to freelance journalists, otherwise known as entrepreneurial journalists, due to their autonomous nature, to understand the ethical dilemmas they may be entangled in primarily. This study seeks to address this gap in research. …

Effects Of Interdependent Group Contingencies On Physical Activity, Katherine A. Cucinotta

Graduate Theses, Dissertations, and Problem Reports (ETD)

Physical inactivity amongst adults in the United States is increasing. In West Virginia, 28.5% of adults 18 years of age or older report not engaging in leisure-time physical activity (West Virginia Department of Health and Human Resources, Health Statistics Center, 2020). Physical inactivity costs $117 billion annually in health-related expenses in the United States and is associated with 10% of premature deaths (Department of Health and Human Services, 2018). As the number of physically inactive adults increases, it is important to find interventions that increase physical activity. Behavioral interventions, such as contingency management and group contingencies, have been employed to …

One Voice Training To Enable Nurses And Anesthesia Providers To Mitigate Pediatric Presurgical Anxiety, Sarah E. Hinnant

Graduate Theses, Dissertations, and Problem Reports (ETD)

ABSTRACT

ONE VOICE Training to Enable Nurses and Anesthesia Providers to Mitigate Pediatric Presurgical Anxiety

Sarah E. Hinnant

Background: Children in the preoperative area experience presurgical anxiety at rates of up to seventy-five percent. Increased pediatric anxiety is directly linked to increased anesthetic requirements, increased risk for development of emergence delirium, and increased time spent in the post anesthesia care unit. Numerous high-quality studies show that intervention by a certified child life specialist mitigates preoperative pediatric anxiety. Often child life specialists are not available to meet with all children prior to surgery. Registered nurses (RNs) and certified registered nurse anesthesiologists …

Negative Forces In Consumption: Their Unpleasant But Undeniable Influence On Consumers, Yumei Mu

Graduate Theses, Dissertations, and Problem Reports (ETD)

An unfortunate reality of consumer behavior is that it has a negative side: Consumers can experience negative emotions (Harrison-Walker, 2019); firm-consumer relationships can grow sour (Do, 2019); and so on. Already quite prevalent, negative forces in consumption have only increased lately because of the COVID-19 pandemic (Gaydos, 2020). Given the pervasiveness of negative forces in consumer behavior, it is very important for consumer psychologists to study them. To that end, the three essays in this dissertation explore wide-ranging facets of negative forces in consumer behavior and, collectively, greatly augment the field’s understanding of the behaviors, processes, and outcomes comprising the …

Community And Key Player Detection For Disrupting Illicit Drug Supply Networks In Social Media Platforms – Especially On Instagram, Akassi Rachel Niamke Aman

Graduate Theses, Dissertations, and Problem Reports (ETD)

This thesis focuses on the pressing issue of illicit drug trafficking and its impact on public health and safety at a global level. With the advent of digital technologies and social media platforms, combating drug trafficking has become increasingly challenging for law enforcement and researchers alike. Among these platforms, Instagram, a popular photo and video-sharing social networking platform, has emerged as a prominent hub for drug trafficking activities.

In this study, we delve into the effectiveness of community and key player detection algorithms in identifying and disrupting illicit drug supply networks on Instagram. To conduct our research, we collected real …

Specialized Metabolism In Retina, Retinal Pigmented Epithelium, And Testis, Siyan Zhu

Graduate Theses, Dissertations, and Problem Reports (ETD)

The retina and its neighboring retinal pigmented epithelium (RPE) are high energy-demanding and metabolically active tissues with specialized and complementary metabolism. They are metabolically interdependent and impact each other’s viability. Interestingly, many of the metabolic features in the retina and RPE are shared with the testis. For example, testis is also energy costly due to continuous sperm differentiation and it has similar metabolic inter-dependence between different testis cells. Both the retina and testis are vulnerable to mitochondrial metabolic impairments.

We conducted three research projects to understand 1) the nutrient utilization and communication in retina and RPE; 2) The profiling of …

Unconventional Wisdom In Resonating Echoes Of The Past: A Memoir On The Life And Music Of Royal Hartigan, Joseph Elias Boulos

Graduate Theses, Dissertations, and Problem Reports (ETD)

Unconventional Wisdom in Resonating Echoes of the Past:

A Memoir on the Life and Music of royal hartigan

Joseph Elias Boulos

Detailed fieldwork achieved by people in the discipline of social/humanistic studies, specifically ethnomusicologists, in any form: book, biography, documentary, etc., have contributed to the strengthening the understanding of any group of people, community, or culture. This research project is a co-authored memoir grounded in oral history and collaborative ethnography on, and with, Dr. royal hartigan. The purpose of this ethnographic research is to fill in the lack of information readily available on royal, from his sole perspective, and to …

Effects Of Invasive Species On Ohio River Zooplankton, Samuel John Johnston

Graduate Theses, Dissertations, and Problem Reports (ETD)

Invasive species have the potential to dramatically change both aquatic and terrestrial ecosystems with rates of introduction only expected to increase across the Globe. In the Mississippi River basin filter feeding silver (Hypophthalmichthys molitrix) and bighead carp (Hypophthalmichthys nobilis) collectively known as invasive carp were introduced into aquaculture ponds where they subsequently escaped and spread to interconnected basins. Invasive carp have not yet completely established throughout the entire Ohio River. Managers recognize three distinct phases of carp invasion: establishment front, invasion front and presence front. In the Illinois River invasive carp are very well established and …

Development Of Machine Learning Based Approach To Predict Fuel Consumption And Maintenance Cost Of Heavy-Duty Vehicles Using Diesel And Alternative Fuels, Sasanka Katreddi

Graduate Theses, Dissertations, and Problem Reports (ETD)

One of the major contributors of human-made greenhouse gases (GHG) namely carbon dioxide (CO2), methane (CH4), and nitrous oxide (NOX) in the transportation sector and heavy-duty vehicles (HDV) contributing to about 27% of the overall fraction. In addition to the rapid increase in global temperature, airborne pollutants from diesel vehicles also present a risk to human health. Even a small improvement that could potentially drive energy savings to the century-old mature diesel technology could yield a significant impact on minimizing greenhouse gas emissions. With the increasing focus on reducing emissions and operating costs, there is a need for efficient and …

Source Credibility And Trust Of Media Information Based On Gender Of Reporter, Madison R. Urse

Graduate Theses, Dissertations, and Problem Reports (ETD)

An experiment was used for this study to explore if the gender of a reporter impacts perceived source credibility and thus trust in information. Previous research has shown how gender biases can affect how topics are covered, reported on, perceived and marketed in the journalistic world. Modern media and newsrooms are meant to mirror reality as they convey information to the public, yet women continue to be gatekept out of reporting on certain types of news. Further, changes in the mode of delivery of news are also impacting the journalism landscape. Thus, this study employed a digital stimulus to explore …

Synthesis And Pharmacology Of Illudalic Acid And Analogous Chemical Structures, Robert Gaston Jr

Graduate Theses, Dissertations, and Problem Reports (ETD)

Natural products are the foundation of modern medicine and an inspiration for chemical innovation. Developing new synthetic strategies to complex natural products drives synthetic innovation and promotes pharmacological exploration. As bioactive secondary metabolites of fungi, illudalic acid and associated analogs have unrealized medicinal potential due to synthetic limitations. Illudalic acid is notably the first selective covalent inhibitor of the LAR-PTPs, a class of enzymes linked to many human illnesses, including stimulant addiction. The chemistry herein focuses on optimizing synthetic routes to illudalic acid and associated analogs toward exploring their pharmaceutical potential. We report a second-generation synthesis of illudinine (55% overall …

You've Got A Friend: Social Factors And Depressive Symptoms In Older Adults, Erika A. Fenstermacher

Graduate Theses, Dissertations, and Problem Reports (ETD)

Depression in late life has been associated with disability, lower quality of life, increased mortality, and increased risk of suicide (Fiske et al., 2009; Rodda et al., 2011). Research suggests that functional disability, which is often brought about by a medical condition, may precede depressive symptoms and may be a major factor for older adults developing depression (Ormel et al., 2002). Social support can be beneficial for both emotional and physical health (Fiori & Jager, 2021). Numerous studies found evidence that social networks, perceived and subjective social support, and satisfaction with support received moderated the relation between health problems and …

Queer Ways Of Seeing Queer Ways Of Depicting: Ellsworth Kelly’S Afterlives And The Liberatory Burden Of Modernist Formalism, J. Zach Hunley

Graduate Theses, Dissertations, and Problem Reports (ETD)

Ellsworth Kelly (1923-2015) was a prolific artist whose career spanned six decades. During that time, Kelly forged new ground stylistically through his unwavering devotion to formalism. Derived from his keen eye for observing his quotidian surroundings, the masking of readymade sources via abstraction has become the understanding central to scholarship on the artist. Kelly’s practice of veiling the subject also reveals a vast, complex matrix of sociohistorical forces related to and stemming from his positionality as a gay man—the significance of which has been generally discounted or omitted from understandings of Kelly within the art historical canon.

This thesis probes …

Assessing Forest Features And Nocturnal Flying Insect Diversity As Predictors Of Eastern Whip-Poor-Will Occupancy In Foraging Habitat, Clark D. Alexander

Graduate Theses, Dissertations, and Problem Reports (ETD)

Eastern whip-poor-will (Antrostomus vociferus), an insectivorous caprimulgid, have seen an approximate 2.76% annual population decrease since the 1960s, with their breeding and foraging ecology largely unknown due to their nocturnal and cryptic behavior. I conducted research to assess abiotic and biotic variables correlated with detection, and occupancy probability, and prey species diversity on ~104,000 hectares of forest in West Virginia, owned by the private timber company Weyerhaeuser. Previous literature indicates that Eastern whip-poor-will, and their prey, require ephemeral habitat such as recently cleared and early successional forests, like those historically created by forest fires, wind shears, hurricanes, and …

“Building The Roots”: A Delphi Study Examining The Aims Of A Multicultural Competency Graduate Course In Sport And Exercise Psychology, Matthew Paul Gonzalez

Graduate Theses, Dissertations, and Problem Reports (ETD)

Historically, opportunities to develop cultural competency in sport and exercise psychology graduate programs have been limited (Lee, 2015). Recently, major sport psychology organizations across the world have started to require cultural competency in their credentialing requirements. While this represents progress, these requirements can be met with a single course, which falls below the ideal of integrated cultural competency education (Martens et al., 2000). The present study investigated how to maximize the quality of a single course by coming to agreement on a proposed set of impactful and feasible learning outcomes and assessments in that proposed single course related to cultural …

Analysis Of The Psychological And Production Effects Of The Use Of Gamification For Manufacturing Assembly, Makenzie Dolly

Graduate Theses, Dissertations, and Problem Reports (ETD)

In this dissertation, the applications of gamification for manufacturing with a focus on effects to workers and productivity were studied. Gamification is a relatively new research area, with the term being officially defined in 2010. Since then, several fields (education, health, and marketing) have benefitted from its application. Despite exhibiting strong potential, the application of gamification had remained rather unexplored in the manufacturing domain. To explore this further, by employing a comprehensive literature review, four research gaps were identified: the need for i) the use and acceptance of Deterding’s definition of gamification, ii) a clearer definition for various game element …

Another Covid Causality: Media Landscape In Bangladesh, Ershad Komal Khan

Graduate Theses, Dissertations, and Problem Reports (ETD)

This study seeks to understand the pressure from both advertisers and the Bangladesh government on the local mass media between March 2020 and December 2021 concurrent with the impacts of the COVID-19 pandemic. Thus, this study aims to explore whether the local mass media compromised more with advertisers amid the COVID recession to earn advertising-based revenue and whether the Bangladesh government mounted more pressure on the press during the period as well as to analyze the influence of the aforementioned factors on newsrooms. To guide this work, this study employs the Market Theory of News Production (McManus, 1994), the Authoritarian …

The Truth-Default, Diagnostic Utility, And The Value Of Contextual Knowledge In Deceptive Interactions, Heath A. Howard

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation describes and reports an experimental study examining the predictions of truth-default theory (TDT). TDT is an expansive, modular theory of deception detection which explains the processes by which people abandon the truth-default state and navigate judgments of message veracity in conversations. The first goal of this study was to test TDT’s seventh proposition, which explains how communicators abandon the truth-default state through trigger events (i.e., actions which prompt communicators to be uncertain about the accuracy of the message) such as decreased sender believability and message coherence. The second goal of this study was to test the predictions of …

Hypoxia Regulates Vessel-Modifying Macrophages And Vice Versa In Tumors, Kayla Jo Steinberger

Graduate Theses, Dissertations, and Problem Reports (ETD)

Hypoxia, or low oxygen, is a common feature of solid tumors correlating with poor survival in cancer patients. Growing tumors need a blood supply to deliver oxygen. Tumors attempt to re-acquire oxygen by forming new blood vessels from nearby, pre-existing vessels, a process known as angiogenesis. Past treatments aimed at preventing this process yielded not only disappointing results in the clinic but sometimes worsened the patient’s prognosis making the tumor more hypoxic, emphasizing the urgent need for novel targets. In tumors, angiogenesis is notoriously dysfunctional resulting in leaky, under-perfused blood vessels which cannot adequately deliver oxygen and exacerbates hypoxia. Emerging …

Working With Community Partners In Wv: Learning How To Frame Health Equity In Physical Activity Interventions, Karly Marie Casanave-Phillips

Graduate Theses, Dissertations, and Problem Reports (ETD)

Developing physical activity interventions that reach underserved populations and increase equitable access requires knowledge of health equity (Bantham et al., 2021). Thus, as funding organizations push for use of community engaged approaches, it becomes important to gauge what community leaders know about health equity. The present study employed surveys and semi-structured interviews to explore community partners’ understanding and perceptions of health equity, as well as benefits and barriers to promoting health equity in their communities. Participants (n = 20) were capacity-building grant applicants recruited through the Center for ActiveWV. Reflexive thematic analysis was used to develop two higher order …

A Longitudinal Study Of Factors That Affect User Interactions With Social Media And Email Spam, Wojciech M. Mazurek

Graduate Theses, Dissertations, and Problem Reports (ETD)

Given the rapid growth of social media and the increasing prevalence of spam, it is crucial to understand users’ interactions with unsolicited content to develop effective countermeasures against spam. This thesis focuses on exploring the factors that influence users’ decisions to interact with spam on social media and email. It builds upon prior work, which serves as a foundation for further research and conducting a longitudinal analysis. Our results are based on the analysis of 221 responses collected through an online survey. The survey not only gathered demographic information such as age, gender, and race but also collected data on …

Study Of Capillary Channel Fiber Augmented Geobags For Accelerated Dewatering Of High Moisture Content Fine-Grained Acid Mine Drainage Precipitate, Luke William Daugherty

Graduate Theses, Dissertations, and Problem Reports (ETD)

The objective of this study was to investigate techniques to accelerate filtration and dewatering of Acid Mine Drainage precipitate using geobags augmented with Capillary Chanel Fibers and internal lateral drainage structures. Laboratory and field research investigated increasing the total solids retention of Acid Mine Drainage precipitate in geobag storage systems. Current geobag design and field application of treated AMD precipitate exhibits limited filtration and drainage efficiency due to the high moisture content (2500%) polymer amended AMD flocculated solids. Capillary channel fibers (CCFs) are geosynthetic yarns formed with microgrooves and set into bundled arrangements capable of wicking water, via capillary action, …

Component Optimization Of A Parallel P4 Hybrid Electric Vehicle Utilizing An Equivalent Consumption Minimization Strategy, Holden Ryan Fraser

Graduate Theses, Dissertations, and Problem Reports (ETD)

Advancements in battery and electric motor technology have driven the development of hybrid electric vehicles to improve fuel economy. Hybrid electric vehicles can utilize an internal combustion engine and an electric motor in many configurations, requiring the development of advanced energy management strategies for a range of component configurations. The Equivalent Consumption Minimization Strategy (ECMS) is an advanced energy management strategy that can be calculated in-vehicle in real-time operation. This energy management strategy uses an equivalence factor to equate electrical to mechanical power when performing the torque split determination between the internal combustion engine and electric motor. This equivalence factor …

An Empirical Analysis Of Approximation Algorithms For The Unweighted Tree Augmentation Problem, Jacob Thomas Restanio

Graduate Theses, Dissertations, and Problem Reports (ETD)

In this thesis, we perform an experimental study of approximation algorithms for the tree augmentation problem (TAP). TAP is a fundamental problem in network design. The goal of TAP is to add the minimum number of edges from a given edge set to a tree so that it becomes 2-edge connected. Formally, given a tree T = (V, E), where V denotes the set of vertices and E denotes the set of edges in the tree, and a set of edges (or links) L ⊆ V × V disjoint from E, the objective is to find a set of edges …

Program Evaluation Of A Type 1 Diabetes Transition Process For Emerging Adults, Anna J. Shashura

Graduate Theses, Dissertations, and Problem Reports (ETD)

Purpose: To evaluate a structured transition program, Preparing Emerging Adults with Knowledge and Skills (PEAKS), for pediatric patients with type 1 diabetes (T1D) in an outpatient pediatric endocrinology center.

Design and Methods: Program evaluation was completed following the Centers for Disease Control and Prevention Framework for Program Evaluation in Public Health, focusing on implementation adherence, glycosylated hemoglobin (HbA1C), and provider satisfaction for the first three visits of the PEAKS program. Satisfaction was assessed using the Got Transition Sample Health Care Transition Feedback Survey for Clinicians. Implementation adherence and HbA1C were gathered using retrospective chart review.

Results: Less than half …

Elucidating Mechanisms Of Proteasome Modulation By Small Molecules To Treat Neurodegenerative Diseases And Cancer, Janelle Joo Yee Chuah

Graduate Theses, Dissertations, and Problem Reports (ETD)

Maintaining protein homeostasis, or proteostasis, is crucial for cellular function, and protein degradation through the proteasome plays a pivotal role in this process. Dysregulation of the proteasome can lead to proteostasis collapse and has been linked to the development of neurodegenerative diseases and cancers. Neurodegenerative diseases often exhibit proteasome impairment, whereas proteasome upregulation is frequently observed in cancer. Although the use of proteasome inhibitors as a pharmaceutical approach has shown success in certain cancers, it has yet to demonstrate efficacy in neurodegenerative diseases due to the absence of drug-like small molecules capable of effectively reversing proteasome impairment and/or activating the …