Digital Commons Network^™

Gaba Transporter Loss-Of-Function Mutations In Pediatric Epilepsy: Neural Mechanisms And A Novel Fatty Acid Based Therapeutic Approach, Alessandra G. Jester

Graduate Student Theses, Dissertations, & Professional Papers

An increasing number of spontaneous mutations in the GABA transporter gene SLC6A1 (GAT-1) have been associated with pediatric epilepsy and neurodevelopmental disorders. The molecular mechanisms and impact of mutations on GABA homeostasis and neuronal circuit function are poorly understood. Furthermore, there are currently no validated therapeutic approaches to treat patients. A de novo mutation (S295L) in the GABA transporter gene SLC6A1 that was identified in a pediatric patient was introduced into a human cDNA construct, and mutant and wild-type transporters were expressed and studied in Xenopus oocytes by voltage clamp and radiolabeled GABA flux measurement. In addition, the effect of …

Impact Of Emotion Regulation On Prospective Memory, Hannes Heppner

Graduate Student Theses, Dissertations, & Professional Papers

Prospective memory necessitates the deliberate formation and timely execution of preplanned intentions. The degree of cognitive demand required is thought to be lower for focal compared to non-focal prospective memory cues. While negatively evocative focal cues have been shown to improve prospective memory performance, it is unclear if and to what extent the cognitive reappraisal of negative emotion impacts prospective memory performance. Cognitive reappraisal is often utilized to help individuals effortfully attenuate negative emotions and reduces the chronic burden on cognitive resources. In the present study, we hypothesized that more effective cognitive reappraisal is associated with better prospective memory performance. …

Niipáitapiiyssin: How Blackfeet Ways Of Knowing Impact Identity And Well-Being, Mikalen Running Fisher

Graduate Student Theses, Dissertations, & Professional Papers

This thesis explores the vital role of history, traditional knowledge, traditional ecological knowledge, artifacts, and language in shaping the identity and well-being of Indigenous communities. It emphasizes how these components are vital for the survival and growth of Indigenous cultures. Using the Blackfoot Confederacy as a case study, the research highlights the significance of these elements in maintaining cultural continuity and resilience. The analysis is grounded in literature authored from an Indigenous perspective, ensuring an authentic representation of the values and insights inherent in these communities. This work aims to bridge existing gaps in the literature by demonstrating the profound …

Ai-Powered Educational Tools And Their Effect On Student Motivation In Online Learning Environments: A Preliminary Study, Caitlin M. Byers

Graduate Student Theses, Dissertations, & Professional Papers

This thesis investigates the impact of an AI-powered educational tool on high school student motivation in asynchronous online courses using Self-Determination Theory (SDT) to examine perceived competence, autonomy, and relatedness. A pilot study involving 129 students utilized an AI-powered automated feedback (AF) writing review tool. Data was collected using the Autonomy and Competence in Technology Adoption (ACTA) Questionnaire and teacher communications. Findings indicate that AI tools can enhance perceived competence through immediate, personalized feedback. Still, the effectiveness is significantly influenced by the level of teacher communication, underscoring the need for a blended approach in online learning environments. Limitations include a …

Sequence Similarity Search Optimization: Prefiltering Strategies And Exact Matching Techniques For Biological Sequence Data, Tim Anderson

Graduate Student Theses, Dissertations, & Professional Papers

Sequence similarity search is one of the most important tasks in the field of bioinformatics. The identification of regions of similarity between one protein or DNA sequence and a separate collection of sequences or models of sequence families has wide-ranging applications. These range from mapping of RNA sequence reads to a given genome to the annotation of gene-encoding regions and the reconstruction of evolutionary relationships of species. As genetic sequencing technologies have improved over the last few decades, the size of genetic sequence databases has grown exponentially. With this growth of sequence databases, more efficient algorithmic approaches are needed to …

Leaving Them In Stitches: Novel Methods For Splice-Aware Sequence Annotation, Alexander Nord

Graduate Student Theses, Dissertations, & Professional Papers

Pre-mRNA intron splicing is essential to the production of many eukaryotic proteins, but it is relatively uncommon for sequence analysis tools to account for this process in their methods. In this dissertation I present three tools for biological sequence analysis, demonstrating the benefits that they derive from their explicit awareness of intron splicing. First, I present Mirage2, an updated implementation of the Mirage multiple sequence alignment program, which produces alignments of protein isoforms according to spliced genome mapping coordinates. I then present Diviner, which synthesizes the output data produced by Mirage2 to locate novel coding regions on eukaryotic …

Defining Lgbtqia2+ Specialized Substance Use Treatment Services From A Client-Informed Approach, Chonghui (Gabriella) Ji

Graduate Student Theses, Dissertations, & Professional Papers

Background: This study explored the concept of specialized substance use treatment services among a sample of Lesbian, Gay, Bisexual, Transgender, Queer and/or Questioning, Intersex, Asexual, and Two-Spirit (LGBTQIA2+) individuals: their definition, perceived barriers to receiving these services, and ways of improving such services. Having direct input from past and potential treatment-seeking LGBTQIA2+ individuals could help to deepen our understanding of how to meet the unique treatment needs of these populations.

Method: Data were collected from 219 LGBTQIA2+ individuals within the United States through an online and anonymous survey. Inclusion criteria for participation were self-identifying as LGBTQIA2+, being 18 years of …

Comprehensive Case Report Umfc#140, Marymargaret C. Pratt

Graduate Student Theses, Dissertations, & Professional Papers

University of Montana Forensic Collections (UMFC) Case #140 was observed and recorded fall 2024. The information included are a complete biological profile, any taphonomic features or pathological conditions present, and a literature review on forensic odontology due to the severe nature of the teeth. This individual is consistent with a 5'2"-5'6" adult male ranging between the ages of 35-50 of ambiguous population affinity. Evidence of osteoarthritis and bone spurs are present along the vertebral spine, clavicle, and articulation points throughout the post-cranial skeleton. There is severe dental attrition found along the buccal view of the maxillary and mandibular molars. The …

A Narrative Map Of Fort Missoula: Silence, Stillness And Death In Living Cultural Memory, Daniel A. Goldhamer

Graduate Student Theses, Dissertations, & Professional Papers

Fort Missoula is a rare site of history, memory, and narrative. This project seeks to trace the complex web of identities and relationalities at the Fort through a narrative map: a method that combines site-based ethnography and qualitative storytelling relying on first-person perspective. This methodological framework reveals that Fort Missoula’s distinct character lies in its role as a living archive of cultural memory, accessible through the past, present, and future narratives of its places and spaces. Engaging with the theories of Foucault (1972), de Certeau (1984), and Low (2017), the narrative map of Fort Missoula is a work that investigates …

Traditional Chinese Medicine And The Argument For Future Application In The United States, Kylie Nicole Frohlich

Graduate Student Theses, Dissertations, & Professional Papers

No abstract provided.

Characterizing Mountainous Bedrock Groundwater Systems Across Gradients In Topography And Lithology In Western Montana, David L. Baude

Graduate Student Theses, Dissertations, & Professional Papers

Mountain aquifer groundwater systems remain one of the least understood hydrologic systems in upland hydrology. In this study, we aim to characterize bedrock groundwater system dynamics and bedrock-saprolite interactions across a variety of landscape positions and lithology. We investigate groundwater hydraulics, recharge temperature and elevation, residence times, and bedrock recharge rates across two mountainous headwater catchments in west central Montana. We used a suite of environmental tracers (³H, CFCs, SF₆, and ⁴He) and residence time distribution models to estimate groundwater mean residence times over a range of timescales from decades to millennia. Tracers were sampled …

Where The Framework Ends: Equity Considerations And Limitations During Agency River Permit Allocation Decision Making Processes, Kelsey Ellen Phillips

Graduate Student Theses, Dissertations, & Professional Papers

River recreation in the U.S. increased dramatically in the 1970s as boating technology and recreational skill level shifted, thus a number of federally- and state-managed river areas instituted use limits over the years to prevent the environmental and social impacts perceived to have stemmed from increased use. These river managers were then faced with the task of allocating this use between private and commercial users (allotment) and within these groups (rationing), complicated by the fact that members of the public perceive equity differently. Early recreation use allocation research explored how different rationing techniques favor different groups, for example those with …

The Other Identity Politics: Political Turning Points And Political Identity Development In College-Going Emerging Adults, Kaetlyn Jeanette Cordingley

Graduate Student Theses, Dissertations, & Professional Papers

Emerging adulthood is a critical developmental period, especially for identity– the development of our sense of who we are internally and relative to others. This research sought to investigate one understudied aspect of identity development: political identity. Five questions guided this research: first, is political identity related to broader identity development? Second, does political identity development differ based on political ideology (liberal, moderate, conservative)? Third, do individuals’ self-identified political turning point events differ based on political ideology? Fourth, how is political identity development related to political turning point narratives? Fifth, how does meaning making interact with political identity development and …

The Blackfeet Nation’S Bison Conservation Herd Management Plan, Brandon Kittson

Graduate Student Theses, Dissertations, & Professional Papers

This document is meant to act as a guide to understanding Bison reintroduction on the Blackfeet reservation and serve as a resource for bison management. This report and plan will: 1) review bison ecology and the history of reintroduction efforts on the reservation; 2) identify potential issues and barriers to successful reintroduction; 3) present a summary of current land policies and patterns of land use on the reservation; and 4) provide recommendations for dealing with those potential issues. Recommendations will be based on analyses of previous knowledge of bison and bison behavior.

Farey Recursion And Hyperbolic Dehn Filling, Jose Ebenezer Martinez

Graduate Student Theses, Dissertations, & Professional Papers

In this work, we present a solution to William Thurston's edge gluing equations for Dehn fillings of hyperbolic 3-manifolds. This is done for triangulations that involve the layered solid torus. Our approach uses Farey recursive functions, and we present a Farey recursive function that provides a solution to the gluing equations for any hyperbolic Dehn filling admitting a triangulation by the layered solid torus. We provide examples that demonstrate our solution for multiple 3-manifolds, and study the roots of the corresponding Farey recursive polynomials. As an additional application of our solution, we provide a formula for the complex length of …

Foreign Expert: A Memoir Manuscript, Jenny L. Rowe

Graduate Student Theses, Dissertations, & Professional Papers

This is a full memoir manuscript that I wrote for my MFA thesis, which is tentatively titled Foreign Expert. In this manuscript, we follow myself as narrator as I struggle to adapt to life in Beijing (prior to the pandemic) while also recovering from a recent divorce. The man I’d been married to for five years back in Iowa had become violently mentally ill, and though I’d been fortunate enough to remove myself from him, I quickly learned that being a foreign expert in China—my residential visa title—required more work than basic survival. By the end of my two years …

Big Sky Above, Big Space Below: Montana Is A Frontier For Deep Carbon Storage, Najifa Farhat

Graduate Student Theses, Dissertations, & Professional Papers

The Snowy River Carbon Sequestration Project in southeastern Montana aims to store carbon dioxide emissions from two Wyoming power plants deep underground. This project aligns with new federal pollution regulations emphasizing carbon storage. Previously, carbon capture and storage (CCS) was mainly used to enhance oil production, but it's now transitioning to focus solely on emission reduction due to government incentives. The project represents Montana's first venture into using public lands for carbon storage, a trend expected to grow significantly with future federal mandates. Fossil fuel companies are investing heavily in CCS technology, with an eye on emission reduction rather than …

Reimagining The Accuracy Of The Lovejoy Et Al. (1985) Age Estimation Method Of The Auricular Surface Of The Ilium Through Modern Color Photographs, Alyssa L. Edwards

Graduate Student Theses, Dissertations, & Professional Papers

The ability to accurately estimate the age at time-of-death of an individual is crucial in numerous fields, particularly in a biological or forensic context. There are various methods, features, and bones that are utilized for determining the estimated age of an individual. This study dives into the Lovejoy et al. (1985) age estimation method of the auricular surface of the ilium by using the current age phase descriptions against different reference photos. The study tests whether updated color photos, when working collaboratively with the current age phase descriptions, increases the age estimation accuracy when estimating age based on the auricular …

Foodway Comparions And Patterns Of Consumer Behavior: The Use Of Orphan And Salvage Archaeological Collections From Historic Missoula, Montana, Emily Thea Meick

Graduate Student Theses, Dissertations, & Professional Papers

The goal of this project is to better understand and test theories about consumer behavior and meat consumption through faunal remains using orphaned and salvaged historic archaeological collections from three sites across Missoula, Montana, from the 1860s through the 1920s. Previous research underscored the need for properly defined units of analysis that represent what was being purchased and consumed. Using a consumer behavior framework and meat quality index, as indicated by price and meat yield, foodways comparisons between a Euromerican household that maintained renters, occupants of a Chinese store, Joss House, and residential dwellings within Missoula’s Red-Light District, and enlisted …

Paragenesis Of The Austin Chalk Formation In Southwest Texas, Mitchell C. Sherry

Graduate Student Theses, Dissertations, & Professional Papers

Presented in this study is a detailed investigation of the paragenesis and diagenetic processes of the Austin Chalk Formation in southwest Texas, utilizing a combination of core-based, petrographic, mineralogic, SEM, and geochemical based analyses. This study is conducted on a single whole rock core from an oil and gas producing well in Webb County, Texas. At this distal shelf location within the Maverick Basin, the Austin Chalk Formation consists of foraminiferal wackestones, siliceous wackestones, foraminiferal mudstones, bentonites, and foraminiferal packstone facies. These facies were deposited below wave base through pelagic, hemipelagic, and gravity driven processes. Petrographic and SEM analyses reveal …

A Soil-Plant-Atmosphere Continuum Model To Simulate Seedling Response To Water Stress, Michael Kurt Kendree Jr.

Graduate Student Theses, Dissertations, & Professional Papers

Most current ecohydrologic models simplify the hydraulics that are at play in plant-water relationships by assuming that the water content within the plant is static. In reality, plants have a relative water content that varies with time in response to environmental stresses. To some extent, variations in plant relative water content are regulated by changes in the osmotic potential of water within plant cells, which contributes to the resilience of plants during periods of water shortage. We present a model that simulates plant water transport and storage within the soil-plant-atmosphere continuum. The model incorporates the role of osmotic regulation in …

A Sport Coach's Role In Motivating Athletes, Tarek Farouk

Graduate Student Theses, Dissertations, & Professional Papers

Athlete motivation, sport psychology, and coaching are intricately connected through the purpose of increasing athletic performance, persistence, and overall success. As mentors, sport coaches play an integral role in affecting an athlete’s motivation by tending to their psychological needs to perform optimally. This paper explores how coaches can leverage visualization, verbal encouragement, mental imagery, and goal setting as ways to enhance athlete motivation and improve performance. By integrating these techniques, coaches can create a supportive and motivating environment that fosters both physical and psychological development in athletes. The paper also examines the principles of sport psychology, emphasizing the importance of …

Forbidden Substructure Problems In Graphs And Hypergraphs, Van Miller Magnan

Graduate Student Theses, Dissertations, & Professional Papers

No abstract provided.

Representing High-Fidelity Geospatial Data In Unreal Engine: Establishing A Foundation For Numerical Computation And Simulation In A Virtual Reality Environment, Hannah E. Gedlaman

Graduate Student Theses, Dissertations, & Professional Papers

This thesis presents a method for integrating high-fidelity geospatial data into Unreal Engine, creating a foundation for numerical computation and simulation in a virtual reality (VR) environment. The research focuses on developing tools that facilitate the incorporation of geospatial data into Unreal Engine, essential for visualizing and accessing data needed to develop training resources for high-risk professions, such as wildland firefighting. This includes the creation of custom plugins for both QGIS and Unreal Engine, forming a data pipeline that establishes a robust data foundation within Unreal Engine. This groundwork enables the development of simulation applications in a VR environment. By …

Genomic And Phenotypic Insights Into The Mechanisms Of Adaptation In High-Elevation Deer Mice, Keely R. Corder

Graduate Student Theses, Dissertations, & Professional Papers

The study of adaptation to extreme environments offers a lens to explore the fundamental processes of evolution. Organisms living in challenging conditions, such as high elevation, must evolve a suite of physiological and genetic adaptations to survive and thrive. However, our understanding of the mechanisms underlying such adaptations and the processes driving their evolution remains incomplete. This dissertation aims to expand our knowledge of adaptive evolution in extreme environments by integrating genomic, phenotypic, and demographic data in the North American deer mouse (Peromyscus maniculatus), a model system for high-altitude adaptation. The dissertation addresses three main gaps in knowledge: (1) the …

Flower Bases In Full Bloom: Intersecting Families And A Generalization Of Diversity, Ryan Wood

Graduate Student Theses, Dissertations, & Professional Papers

In this work, we present results employing the flower base method. We work in the field of extremal set theory, focusing our attention on r-uniform intersecting families. The classic Erd˝os-Ko-Rado Theorem states that, for n large enough, the largest runiform intersecting family, a so-called maximum star, consists of taking all r-sets containing a fixed element. Lemons and Palmer [31] investigated the diversity function, showing that the largest intersecting family that is the most “un-star-like” consists of taking all r-sets containing at least two members of a set of size three. Our main problem, that of C-weighted diversity, unifies these two …

Seeing, Thinking, Doing – A Multifaceted Model To Embrace Uncertainty In Mine Planning, Christopher James Roos

Graduate Student Theses, Dissertations, & Professional Papers

This dissertation summarizes a multifaceted model for embracing uncertainty within the modern mine planning process. This model – Seeing, Thinking, Doing – aims to introduce technical staff within the mining industry to modern visualization and quantification tools that can aid with understanding and communicating the impact of uncertainty on the optimization of their mine plans.

The dissertation follows the “three-paper” format with the first paper, Modern Visualization to Aid in Communication of Mine Planning Uncertainty, presenting the first aspect of the multifaceted model – seeing. With complex, spatial data, such as the geologic estimate of a mineral deposit, …

Brat Olympics, Caroline Ganci Patterson

Graduate Student Theses, Dissertations, & Professional Papers

brat olympics is an exploration of feminine disgust, apprehension, and disorientation contextualized through interpersonal relationships and societal shapeshifting. It pays particular attention to gender performance, surburban queerness, and strangerness. The manuscript plays on the history of the bildungsroman, but instead of one consistent singular timeline, it provides three separate attempts at a characterization of a life. These disparate approaches to a singular life’s characterization stress the mundanity of documentation.

This multinarrative approach satirizes the ideal of the singular confessional, and presents a discursive approach to the way we choose to build our worlds. Building off the works of the New …

Siksikaitsitapi Returning The Gaze On Human & Wildlife Interactions, Celina C. Gray

Graduate Student Theses, Dissertations, & Professional Papers

In Niitawahsii–our home territory, the ecoregion of the Siksikaitsitapi–Blackfoot Confederacy, a Traditional Ecological Knowledge Application (TEKA) for socio-ecological research was developed. Aawaaahsskataiks–elders and extant literature identified a need to develop shared understanding regarding strong connections to wildlife niksokowaiks–relatives, through Siksikaitsitapi Traditional Ecological Knowledge (S-TEK). Multistage chain referral sampling, semi-structured interviews and grounded theory coding & analysis from Western science, i.e. Napikowaiks–non-natives’ research methods, were adjusted like to align with kipaitapiwahsinnooni–the Blackfoot paradigm of traditional knowledge; and more generally, Indigenous Research Methods. The result was a rigorous qualitative human-dimension of wildlife research TEKA; for use by Siksikaitsitapi and others interested in …

Nurture Through Nature – The Impact Of The Environment On Prospective Memory, Emily Catherine Hicks

Graduate Student Theses, Dissertations, & Professional Papers

There is a need for brief, accessible interventions to improve cognitive functioning, including prospective memory. Previous research has found that exposure to nature is linked to benefits for cognition and mood, including improved executive function, working memory, creativity, attention, and mood. However, there is a dearth of literature exploring the relationship between nature exposure and prospective memory. Additionally, benefits for cognition and mood have been observed with direct nature exposure and indirect exposure through videos and images. The present study sought to evaluate the impact of natural setting versus urban setting video exposure on prospective memory, creativity, hope, and affect. …