Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Law (21488)
- Constitutional Law (2015)
- Criminal Law (1294)
- International Law (1136)
- Social and Behavioral Sciences (1123)
-
- Intellectual Property Law (1108)
- Health Law and Policy (1073)
- Business Organizations Law (1067)
- Civil Rights and Discrimination (1041)
- Law and Economics (897)
- Banking and Finance Law (804)
- Law and Society (803)
- Environmental Law (800)
- Criminal Procedure (757)
- Legal Education (684)
- Courts (682)
- Medicine and Health Sciences (671)
- Law and Politics (639)
- Administrative Law (635)
- Law and Gender (622)
- Law and Race (610)
- Securities Law (591)
- Legal History (584)
- Other Law (583)
- Comparative and Foreign Law (565)
- Contracts (553)
- Family Law (527)
- Tax Law (502)
- Legal Profession (488)
- Legal Ethics and Professional Responsibility (482)
- Institution
-
- Columbia Law School (4162)
- Duke Law (3817)
- Boston University School of Law (3117)
- UC Law SF (2083)
- Texas A&M University School of Law (1720)
-
- Brooklyn Law School (1597)
- Case Western Reserve University (1468)
- University of Maryland Francis King Carey School of Law (1459)
- Fordham Law School (1355)
- University of New Mexico (922)
- Mitchell Hamline School of Law (530)
- Penn State Dickinson Law (498)
- California Western School of Law (466)
- Nova Southeastern University (345)
- Lindenwood University (340)
- Western New England University (338)
- Brigham Young University Law School (252)
- Widener University Commonwealth Law School (252)
- Barry University School of Law (245)
- Florida Atlantic University (108)
- Colby College (75)
- James Madison University (49)
- Belmont University (33)
- University of San Diego (25)
- Wofford College (18)
- University of Arkansas Little Rock (12)
- University of Louisiana at Lafayette (11)
- Lesley University (8)
- Otterbein University (8)
- University of Southern Maine (4)
- Keyword
-
- Constitutional law (517)
- SSRN (395)
- Supreme Court (290)
- International law (284)
- Columbia Law Review (271)
-
- Criminal law (267)
- Corporate governance (265)
- Law (259)
- Intellectual property (258)
- Copyright (219)
- Civil rights (214)
- Privacy (213)
- Race (209)
- Human rights (200)
- Discrimination (184)
- Legal education (184)
- Administrative law (180)
- Climate change (177)
- Courts (176)
- United States (173)
- Artificial intelligence (164)
- Judicial review (162)
- Regulation (162)
- Federalism (160)
- Constitution (155)
- First Amendment (146)
- Contracts (145)
- Separation of powers (140)
- Jurisprudence (130)
- Empirical (126)
- Publication Year
- File Type
Articles 1411 - 1440 of 25324
Full-Text Articles in Entire DC Network
The Transformation Of Social Work In Ukraine Before And During The War, Jaroslaw Richard Romaniuk, Kathleen J. Farkas
The Transformation Of Social Work In Ukraine Before And During The War, Jaroslaw Richard Romaniuk, Kathleen J. Farkas
Faculty Scholarship
Background: This article aims to review the development of the social work profession in Ukraine and to describe the impact of social, economic and political changes on social work practices and education. Methods: A comprehensive literature review and participant observation methods informed this study. A case study of a Polish community’s response to Ukrainian war refugees illustrates how social workers might capitalize on current social structures to continue strengthening civil society in Ukraine. Findings and Discussion: Social Work, focusing on the fit between person and environment, is shaped by knowledge, culture and belief systems. Ukraine’s history and transition from communist/centralized …
Preserving Linguistic Diversity In The Digital Age: A Scalable Model For Cultural Heritage Continuity, James Hutson, Pace Ellsworth, Matt Ellsworth
Preserving Linguistic Diversity In The Digital Age: A Scalable Model For Cultural Heritage Continuity, James Hutson, Pace Ellsworth, Matt Ellsworth
Faculty Scholarship
In the face of the rapid erosion of both tangible and intangible cultural heritage globally, the urgency for effective, wide-ranging preservation methods has never been greater. Traditional approaches in cultural preservation often focus narrowly on specific niches, overlooking the broader cultural tapestry, particularly the preservation of everyday cultural elements. This article addresses this critical gap by advocating for a comprehensive, scalable model for cultural preservation that leverages machine learning and big data analytics. This model aims to document and archive a diverse range of cultural artifacts, encompassing both extraordinary and mundane aspects of heritage. A central issue highlighted in the …
Investigation Of Rare Earth Element Binding To A Surface-Bound Affinity Peptide Derived From Ef-Hand Loop I Of Lanmodulin, Geeta Verma, Jacob D. Hostert, Alex A. Summerville, Christine E. Duval, Julie N. Renner
Investigation Of Rare Earth Element Binding To A Surface-Bound Affinity Peptide Derived From Ef-Hand Loop I Of Lanmodulin, Geeta Verma, Jacob D. Hostert, Alex A. Summerville, Christine E. Duval, Julie N. Renner
Faculty Scholarship
Bioinspired strategies have been given extensive attention for the recovery of rare earth elements (REEs) from waste streams because of their high selectivity, regeneration potential, and sustainability as well as low cost. Lanmodulin protein is an emerging biotechnology that is highly selective for REE binding. Mimicking lanmodulin with shorter peptides is advantageous because they are simpler and potentially easier to manipulate and optimize. Lanmodulin-derived peptides have been found to bind REEs, but their properties have not been explored when immobilized on solid substrates, which is required for many advanced separation technologies. Here, two peptides, LanM1 and scrambled LanM1, are designed …
Bipolar Symptoms, Somatic Burden And Functioning In Older-Age Bipolar Disorder: A Replication Study From The Global Aging & Geriatric Experiments In Bipolar Disorder Database (Gage-Bd) Project, Martha Sajatovic, Farren B.S Briggs, Kaylee Sarna, Joy Yala
Bipolar Symptoms, Somatic Burden And Functioning In Older-Age Bipolar Disorder: A Replication Study From The Global Aging & Geriatric Experiments In Bipolar Disorder Database (Gage-Bd) Project, Martha Sajatovic, Farren B.S Briggs, Kaylee Sarna, Joy Yala
Faculty Scholarship
Objectives: The Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE-BD) project pools archival datasets on older age bipolar disorder (OABD). An initial Wave 1 (W1; n = 1369) analysis found both manic and depressive symptoms reduced among older patients. To replicate this finding, we gathered an independent Wave 2 (W2; n = 1232, mean ± standard deviation age 47.2 ± 13.5, 65% women, 49% aged over 50) dataset. Design/Methods: Using mixed models with random effects for cohort, we examined associations between BD symptoms, somatic burden and age and the contribution of these to functioning in W2 and the …
Outcomes Of Hepatic Artery-Based Therapies And Systemic Multiagent Chemotherapy In Unresectable Colorectal Liver Metastases: A Systematic Review And Meta-Analysis, Henry Stitzel, Victoria Wu, David Bajor, Sakti Chakrabarti, Madison Conces, Lauren Henke, Melissa Lumish, Amit Mahipal, Amr Mohamed, Jordan M. Winter, Jeffrey M. Hardacre, John B. Ammori, Jennifer E. Selfridge, Lee M. Ocuin
Outcomes Of Hepatic Artery-Based Therapies And Systemic Multiagent Chemotherapy In Unresectable Colorectal Liver Metastases: A Systematic Review And Meta-Analysis, Henry Stitzel, Victoria Wu, David Bajor, Sakti Chakrabarti, Madison Conces, Lauren Henke, Melissa Lumish, Amit Mahipal, Amr Mohamed, Jordan M. Winter, Jeffrey M. Hardacre, John B. Ammori, Jennifer E. Selfridge, Lee M. Ocuin
Faculty Scholarship
Background: Treatment of unresectable colorectal liver metastases (UCRLM) includes locoregional and systemic therapy. A comprehensive analysis capturing long-term outcomes of these treatment options has not been performed. Objective: A systematic review and meta-analysis was performed to calculate pooled outcomes of hepatic artery infusion with systemic chemotherapy (HAI-S), transarterial chemoembolization with systemic chemotherapy (TACE-S), transarterial radioembolization with systemic chemotherapy (TARE-S), doublet (FOLFOX, FOLFIRI), and triplet chemotherapy (FOLFOXIRI). Methods: Outcomes included overall survival (OS), progression-free survival (PFS), rate of conversion to resection (CTR), and response rate (RR). Results: A total of 32, 7, 9, and 14 publications were included in the HAI-S, …
Seeking Sufficient And Appropriate Care During The First Year After Spinal Cord Injury: A Qualitative Study, Anne M. Bryden, Brian Gran
Seeking Sufficient And Appropriate Care During The First Year After Spinal Cord Injury: A Qualitative Study, Anne M. Bryden, Brian Gran
Faculty Scholarship
Study design: Longitudinal qualitative study, based on a constructivist grounded theory and transformative approach. Objectives: This study investigated experiences of individuals with spinal cord injury (SCI) while navigating rehabilitation, resources for recovery, and community reintegration during the first year after injury. Setting: An acute inpatient rehabilitation facility in the Midwest United States. Methods: In-depth, semi-structured interviews were conducted with 20 individuals with newly-acquired SCI. Interviews were conducted approximately every other month for one year, beginning at acute inpatient rehabilitation. Data were analyzed and interpreted using a constructivist grounded theory approach and transformative paradigm, which examines power and social structures within …
Bst1047+1156: A (Failing) Ultradiffuse Tidal Dwarf In The Leo I Group, J. Christopher Mihos, Stacy S. Mcgaugh
Bst1047+1156: A (Failing) Ultradiffuse Tidal Dwarf In The Leo I Group, J. Christopher Mihos, Stacy S. Mcgaugh
Faculty Scholarship
We use deep Hubble Space Telescope imaging to study the resolved stellar populations in BST1047+1156, a gas-rich, ultradiffuse dwarf galaxy found in the intragroup environment of the Leo I galaxy group. While our imaging reaches approximately two magnitudes below the tip of the red giant branch at the Leo I distance of 11 Mpc, we find no evidence for an old red giant sequence that would signal an extended star formation history for the object. Instead, we clearly detect the red and blue helium-burning sequences of its stellar populations, as well as the fainter blue main sequence, all indicative of …
Bridging The Divide: Improving Digital Humanities Pedagogy By Networking Higher Education And Secondary Education Faculty In St. Louis, Geremy Carnes, Margaret K. Smith
Bridging The Divide: Improving Digital Humanities Pedagogy By Networking Higher Education And Secondary Education Faculty In St. Louis, Geremy Carnes, Margaret K. Smith
Faculty Scholarship
In 2021, faculty at Lindenwood University and Southern Illinois University Edwardsville (SIUE) led the formation of a Saint Louis Digital Humanities (STL DH) Network of faculty and scholars at area universities, schools, and cultural institutions.1 The Lindenwood and SIUE campuses bookend the St. Louis metro area, a region whose strong geospatial presence offers fruitful opportunities for digital humanities (DH) education but which also suffers from long, deeply ingrained economic and racial segregation. While other regional DH networks exist, the STL DH Network is unique in taking undergraduate education and secondary education— and particularly equitable access to education—as its chief focus. …
Association Of Semaglutide With Reduced Incidence And Relapse Of Cannabis Use Disorder In Real-World Populations: A Retrospective Cohort Study, William Wang, Nathan A. Berger, Pamela B. Davis, David C. Kaelber, Rong Xu
Association Of Semaglutide With Reduced Incidence And Relapse Of Cannabis Use Disorder In Real-World Populations: A Retrospective Cohort Study, William Wang, Nathan A. Berger, Pamela B. Davis, David C. Kaelber, Rong Xu
Faculty Scholarship
Cannabis is the most frequently used illicit drug in the United States with more than 45 million users of whom one-third suffer from a cannabis use disorder (CUD). Despite its high prevalence, there are currently no FDA-approved medications for CUD. Patients treated with semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA) approved for treating type 2 diabetes (T2D) and for weight management have reported reduced desire to drink and smoke. Preclinical studies have shown that semaglutide decreased nicotine and alcohol consumption. Preclinical and preliminary clinical evidence of semaglutide’s potential beneficial effects on various substance use disorders led us to evaluate if …
Multispecies Comparative Prostate Anatomy By Imaging: Implications For Experimental Models Of Prostatic Disease, Felipe M. Berg, Eduardo T.O. Correia, Eric C. Abenojar, James P. Basilion, Agata A. Exner, Leonardo K. Bittencourt
Multispecies Comparative Prostate Anatomy By Imaging: Implications For Experimental Models Of Prostatic Disease, Felipe M. Berg, Eduardo T.O. Correia, Eric C. Abenojar, James P. Basilion, Agata A. Exner, Leonardo K. Bittencourt
Faculty Scholarship
Background: There is an increasing interest in using preclinical models for development and assessment of medical devices and imaging techniques for prostatic disease care. Still, a comprehensive assessment of the prostate's radiological anatomy in primary preclinical models such as dogs, rabbits, and mice utilizing human anatomy as a reference point remains necessary with no optimal model for each purpose being clearly defined in the literature. Therefore, this study compares the anatomical characteristics of different animal models to the human prostatic gland from the imaging perspective. Methods: We imaged five Beagle laboratory dogs, five New Zealand White rabbits, and five mice, …
Vibrational Spectrum Of Granular Packings With Random Matrices, Harsh Mathur
Vibrational Spectrum Of Granular Packings With Random Matrices, Harsh Mathur
Faculty Scholarship
Abstract: The vibrational spectrum of granular packings can be used as a signature of the jamming transition, with the density of states at zero frequency becoming nonzero at the transition. It has been proposed previously that the vibrational spectrum of granular packings can be approximately obtained from random matrix theory. Here, we show that the autocorrelation function of the density of states shows good agreement between dynamical numerical simulations of frictionless bead packs near the jamming point and the analytic predictions of the Laguerre orthogonal ensemble of random matrices; there is clear disagreement with the Gaussian orthogonal ensemble, establishing that …
Reclaiming The Symbol: Ethics, Rhetoric, And The Humanistic Integration Of Gai - A Burkean Perspective, Daniel Plate, James Hutson
Reclaiming The Symbol: Ethics, Rhetoric, And The Humanistic Integration Of Gai - A Burkean Perspective, Daniel Plate, James Hutson
Faculty Scholarship
This study delves into the intersection of generative artificial intelligence (GAI) and the Humanities, guided by the critical insights of Kenneth Burke, a seminal figure in the study of rhetoric and a vocal critic of scientism and positivism. The skepticism of the American literary theorist towards an uncritical embrace of science and technology, and his concerns over the inclination of the Humanities to adopt scientific methodologies at the expense of traditional forms of inquiry, provide a critical framework for examining the new role played by GAI within the Humanities. By framing these tools in the context of Burkean rhetorical theory, …
Pathological Mechanisms And Novel Testing Methods In Thrombotic Thrombocytopenic Purpura, Robert W. Maitta
Pathological Mechanisms And Novel Testing Methods In Thrombotic Thrombocytopenic Purpura, Robert W. Maitta
Faculty Scholarship
Thrombotic thrombocytopenic purpura (TTP) is an uncommon, but potentially disabling or even deadly, thrombotic microangiopathy with a well-studied mechanism of ADAMTS13 deficiency or dysfunction. While established treatments are largely effective, the standard ADAMTS13 testing required to definitively diagnose TTP may cause delays in diagnosis and treatment, highlighting the need for rapid and effective diagnostic methods. Additionally, the heterogeneous presentation and varied inciting events of TTP suggest more variation in its mechanism than previously thought, implying three potential pathways rather than the accepted two. The recent discovery of ADAMTS13 conformation as a potential contributor to TTP in addition to the proposal …
Rapid Measurement Of Hemoglobin-Oxygen Dissociation By Leveraging Bohr Effect And Soret Band Bathochromic Shift, Zoe Sekyonda, Ran An, Utku Goreke, Yuncheng Man, Karamoja Monchamp, Allison Bode, Qiaochu Zhang, Ozan Akkus, Umut A. Gurkan
Rapid Measurement Of Hemoglobin-Oxygen Dissociation By Leveraging Bohr Effect And Soret Band Bathochromic Shift, Zoe Sekyonda, Ran An, Utku Goreke, Yuncheng Man, Karamoja Monchamp, Allison Bode, Qiaochu Zhang, Ozan Akkus, Umut A. Gurkan
Faculty Scholarship
Oxygen (O2) binds to hemoglobin (Hb) in the lungs and is then released (dissociated) in the tissues. The Bohr effect is a physiological mechanism that governs the affinity of Hb for O2 based on pH, where a lower pH results in a lower Hb-O2 affinity and higher Hb-O2 dissociation. Hb-O2 affinity and dissociation are crucial for maintaining aerobic metabolism in cells and tissues. Despite its vital role in human physiology, Hb-O2 dissociation measurement is underutilized in basic research and in clinical laboratories, primarily due to the technical complexity and limited throughput of existing methods. We present a rapid Hb-O2 dissociation …
A Mechanochemical Approach To Recycle Thermosets Containing Carbonate And Thiourethane Linkages, Rasoul Rahimzadeh, Yazhe Han, Ica Manas-Zloczower
A Mechanochemical Approach To Recycle Thermosets Containing Carbonate And Thiourethane Linkages, Rasoul Rahimzadeh, Yazhe Han, Ica Manas-Zloczower
Faculty Scholarship
Over the past decades, various industries shifted from traditional materials such as glass and metals to thermoset polymers due to their excellent chemical resistance, thermal stability, reduced weight, and affordability. However, at the end of their life cycle, these highly crosslinked polymers end up as environmental pollutants due to their non-recyclability. To tackle this issue, researchers are exploring vitrimer-type polymers with recyclable qualities, supporting a circular economy and sustainable management of thermoset wastes. This study investigates a new promising method of recycling two commonly used thermosets in commercial applications, poly allyl diglycol carbonate (PADC) and poly thiourethane (PTU), via a …
When And Why Ecological Systems Respond To The Rate Rather Than The Magnitude Of Environmental Changes, Karen C. Abbott
When And Why Ecological Systems Respond To The Rate Rather Than The Magnitude Of Environmental Changes, Karen C. Abbott
Faculty Scholarship
Ecologists and conservation biologists have become quite familiar with the concept of tipping points: abrupt changes in an ecosystem's state that occur after a period of relative stasis. Most of the familiar ecological examples of tipping points occur either because a once-stable state has lost stability, or the system has been subjected to a particularly large perturbation and transitions to an alternative stable state, distinct from the pre-perturbed state. A different class of tipping points, known as rate-induced tipping (or r-tipping) points, are likely present in many ecological communities but remain little known in the field. Rate-induced tipping occurs when …
Depletion Of Complement Factor 3 Delays The Neuroinflammatory Response To Intracortical Microelectrodes, Sydney S. Song, Lindsey N. Druschel, Jacob H. Conard, Jaime J. Wang, Niveda M. Kasthuri, E. Ricky Chan, Jeffrey R. Capadona
Depletion Of Complement Factor 3 Delays The Neuroinflammatory Response To Intracortical Microelectrodes, Sydney S. Song, Lindsey N. Druschel, Jacob H. Conard, Jaime J. Wang, Niveda M. Kasthuri, E. Ricky Chan, Jeffrey R. Capadona
Faculty Scholarship
The neuroinflammatory response to intracortical microelectrodes (IMEs) used with brain-machine interfacing (BMI) applications is regarded as the primary contributor to poor chronic performance. Recent developments in high-plex gene expression technologies have allowed for an evolution in the investigation of individual proteins or genes to be able to identify specific pathways of upregulated genes that may contribute to the neuroinflammatory response. Several key pathways that are upregulated following IME implantation are involved with the complement system. The complement system is part of the innate immune system involved in recognizing and eliminating pathogens – a significant contributor to the foreign body response …
Smart Cities And Aging Well: Exploring The Links Between Technological Models And Social Models For Promoting Daily Social Interaction For Geriatric Care, Jocelyne Kiss, Lindenwood University
Smart Cities And Aging Well: Exploring The Links Between Technological Models And Social Models For Promoting Daily Social Interaction For Geriatric Care, Jocelyne Kiss, Lindenwood University
Faculty Scholarship
The aging global population requires a new social model to meet the growing social, economic, and physical needs of seniors. Western social models need to be reconsidered in light of examples that support communal ways of living, which are sustainable through smart city design for more supportive geriatric care systems. To address the complex problems of geriatric care in this growing aging population with specific needs related to increased lifespan and limited financial resources, the use of emerging technologies, such as artificial intelligence (AI) and the Internet of Things (IoT), should be considered. As retirement ages rise and funds for …
Community Responsive Public Defense, Alexis Hoag-Fordjour
Community Responsive Public Defense, Alexis Hoag-Fordjour
Faculty Scholarship
No abstract provided.
False Conscience: Sustainability And Smart Evolution—Between Law And Power, Ugo Mattei
False Conscience: Sustainability And Smart Evolution—Between Law And Power, Ugo Mattei
Faculty Scholarship
The contribution describes the legal phenomenon as a playing field characterized by a progressive regression of the law, understood as a sovereign will from top to bottom, both in the vision of formalist legal positivisms in continental Europe and in realist terms, in the United States. Soft law represents the main strategy to subordinate the law to the interests of the economy, elasticizing environmental law, making it favorable to the market, reducing ecology to the simplistic metric of CO2 emissions. The consequence is a retreat of the statist vertical normativity of law which is not replaced by a de facto …
It’S Dead! Can Postbiotics Really Help Performance And Recovery? A Systematic Review, Chad M. Kerksick, Jessica M. Moon, Ralf Jäger
It’S Dead! Can Postbiotics Really Help Performance And Recovery? A Systematic Review, Chad M. Kerksick, Jessica M. Moon, Ralf Jäger
Faculty Scholarship
In recent years, postbiotics have increased in popularity, but the potential relevancy of postbiotics for augmenting exercise performance, recovery, and health is underexplored. A systematic literature search of Google Scholar and PubMed databases was performed with the main objective being to identify and summarize the current body of scientific literature on postbiotic supplementation and outcomes related to exercise performance and recovery. Inclusion criteria for this systematic review consisted of peer-reviewed, randomized, double-blind, and placebo-controlled trials, with a population including healthy men or women >18 years of age. Studies required the incorporation of a postbiotic supplementation regimen and an outcome linked …
Milk Or Kefir, In Comparison To Water, Do Not Enhance Running Time-Trial Performance In Endurance Master Athletes, Kristen N. Gross, Patrick S. Harty, Joesi M. Krieger, Petey W. Mumford, Kyle L. Sunderland, Anthony M. Hagele, Chad Kerksick
Milk Or Kefir, In Comparison To Water, Do Not Enhance Running Time-Trial Performance In Endurance Master Athletes, Kristen N. Gross, Patrick S. Harty, Joesi M. Krieger, Petey W. Mumford, Kyle L. Sunderland, Anthony M. Hagele, Chad Kerksick
Faculty Scholarship
This study compared flavored kefir (KFR) and flavored milk (MLK) as a recovery drink in endurance master athletes. Using a randomized, placebo-controlled, non-blinded crossover design, 11 males and females completed three testing visits whilst acutely ingesting either KFR, MLK, or water as a placebo (PLA). KFR supplementation occurred for 14 days before the KFR-testing day, followed by a 3-week washout period. Testing visits consisted of an exhausting-exercise (EE) bout, a 4-h rest period where additional carbohydrate feeding was provided, and a treadmill 5 km time trial (TT). The Gastrointestinal Symptom Rating Scale (GSRS) survey was assessed at four timepoints. Blood …
Sex Differences Among Older Adults With Bipolar Disorder: Results From The Global Aging & Geriatric Experiments In Bipolar Disorder (Gage-Bd) Project, Kaylee Sarna, Joy Yala, Farren B.S. Briggs, Martha Sajatovic
Sex Differences Among Older Adults With Bipolar Disorder: Results From The Global Aging & Geriatric Experiments In Bipolar Disorder (Gage-Bd) Project, Kaylee Sarna, Joy Yala, Farren B.S. Briggs, Martha Sajatovic
Faculty Scholarship
Objective: Sex-specific research in adult bipolar disorder (BD) is sparse and even more so among those with older age bipolar disorder (OABD). Knowledge about sex differences across the bipolar lifespan is urgently needed to target and improve treatment. To address this gap, the current study examined sex differences in the domains of clinical presentation, general functioning, and mood symptoms among individuals with OABD. Methods: This Global Aging & Geriatric Experiments in Bipolar Disorder (GAGE-BD) study used data from 19 international studies including BD patients aged ≥50 years (N = 1,185: 645 women, 540 men).A comparison of mood symptoms between women …
Altered Mitochondrial Respiration In Peripheral Blood Mononuclear Cells Of Post-Acute Sequelae Of Sars-Cov-2 Infection, Sahera Dirajlal-Fargo, Jared C. Durieux, Grace A. Mccomsey
Altered Mitochondrial Respiration In Peripheral Blood Mononuclear Cells Of Post-Acute Sequelae Of Sars-Cov-2 Infection, Sahera Dirajlal-Fargo, Jared C. Durieux, Grace A. Mccomsey
Faculty Scholarship
Peripheral blood mononuclear cells (PBMC) mitochondrial respiration was measured ex vivo from participants without a history of COVID (n = 19), with a history of COVID and full recovery (n = 20), and with PASC (n = 20). Mean mitochondrial basal respiration, ATP-linked respiration, maximal respiration, spare respiration capacity, ATP-linked respiration, and non-mitochondrial respiration were highest in COVID + PASC+ (p ≤ 0.04). Every unit increase in non-mitochondrial respiration, ATP-linked respiration, basal respiration, spare respiration capacity, and maximal respiration increased the predicted odds of PASC between 1 % and 6 %. Mitochondrial dysfunction in PBMCs may be contributing to the …
Investigation Of Flow Boiling Critical Heat Flux And Heat Transfer Within A Horizontally Oriented Channel With One-Sided Heating At Three Levels Of Subcooled Inlet, Chinmay Shingote, Cho Ning Huang, Chirag Kharangate
Investigation Of Flow Boiling Critical Heat Flux And Heat Transfer Within A Horizontally Oriented Channel With One-Sided Heating At Three Levels Of Subcooled Inlet, Chinmay Shingote, Cho Ning Huang, Chirag Kharangate
Faculty Scholarship
The aim of this study is to investigate the impact heater orientation and inlet conditions on heat transfer mechanisms during flow boiling, inside horizontally oriented rectangular channel using PF-5060. The experimental setup allows both upward and downward-facing single-sided heating configurations. Various inlet mass flux are examined, along with different levels of inlet subcooling. The impact of gravity is studied using flow visualization. During downward facing heating, vapor accumulates along the copper heater wall due to buoyancy effects resulting in notably low CHF and heat transfer values. In contrast, with upward facing heating, buoyancy assists in extraction of vapor from the …
Electronic Relaxation Mechanism Of 9-Methyl-2,6-Diaminopurine And 2,6-Diaminopurine-2′-Deoxyribose In Solution, Luis A. Ortiz-Rodríguez, Naishka E. Caldero-Rodríguez, Sourav Kanti Seth, Karitza Díaz-González, Carlos E. Crespo-Hernández
Electronic Relaxation Mechanism Of 9-Methyl-2,6-Diaminopurine And 2,6-Diaminopurine-2′-Deoxyribose In Solution, Luis A. Ortiz-Rodríguez, Naishka E. Caldero-Rodríguez, Sourav Kanti Seth, Karitza Díaz-González, Carlos E. Crespo-Hernández
Faculty Scholarship
Prolonged ultraviolet exposure results in the formation of cyclobutane pyrimidine dimers (CPDs) in RNA. Consequently, prebiotic photolesion repair mechanisms should have played an important role in the maintenance of the structural integrity of primitive nucleic acids. 2,6-Diaminopurine is a prebiotic nucleobase that repairs CPDs with high efficiency when incorporated into polymers. We investigate the electronic deactivation pathways of 2,6-diaminopurine-2′-deoxyribose and 9-methyl-2,6-diaminopurine in acetonitrile and aqueous solution to shed light on the photophysical and excited state properties of the 2,6-diaminopurine chromophore. Evidence is presented that both are photostable compounds exhibiting similar deactivation mechanisms upon the population of the S1(ππ* La) state …
A General Materials Data Science Framework For Quantitative 2d Analysis Of Particle Growth From Image Sequences, Sameera Nalin Venkat, Thomas G. Ciardi, Mingjian Lu, Preston C. Deleo, Jube Augustino, Adam Goodman, Jayvic Cristian Jimenez, Anirban Mondal, Frank Ernst, Yinghui Wu, Roger H. French, Laura S. Bruckman
A General Materials Data Science Framework For Quantitative 2d Analysis Of Particle Growth From Image Sequences, Sameera Nalin Venkat, Thomas G. Ciardi, Mingjian Lu, Preston C. Deleo, Jube Augustino, Adam Goodman, Jayvic Cristian Jimenez, Anirban Mondal, Frank Ernst, Yinghui Wu, Roger H. French, Laura S. Bruckman
Faculty Scholarship
Phase transformations are a challenging problem in materials science, which lead to changes in properties and may impact performance of material systems in various applications. We introduce a general framework for the analysis of particle growth kinetics by utilizing concepts from machine learning and graph theory. As a model system, we use image sequences of atomic force microscopy showing the crystallization of an amorphous fluoroelastomer film. To identify crystalline particles in an amorphous matrix and track the temporal evolution of the particle dispersion, we have developed quantitative methods of 2D analysis. 700 image sequences were analyzed using a neural network …
Understanding The Utility Of Less Than Six-Month Prognosis Using Administrative Data Among U.S. Nursing Home Residents With Cancer, Long Vu, Siran M. Koroukian, Sara L. Douglas, Hannah L. Fein
Understanding The Utility Of Less Than Six-Month Prognosis Using Administrative Data Among U.S. Nursing Home Residents With Cancer, Long Vu, Siran M. Koroukian, Sara L. Douglas, Hannah L. Fein
Faculty Scholarship
Background: There is a dearth of studies evaluating the utility of reporting prognostication among nursing home (NH) residents with cancer. Objective: To study factors associated with documented less than six-month prognosis, and its relationship with end-of-life (EOL) care quality measures among residents with cancer. Methods: The Surveillance, Epidemiology, and End Results linked with Medicare, and the Minimum Data Set databases was used to identify 20,397 NH residents in the United States with breast, colorectal, lung, pancreatic, or prostate cancer who died between July 2016 and December 2018. Of these, 2205 residents (10.8%) were documented with less than six-month prognosis upon …
Expanding The Ban On Forced Arbitration To Race Claims, Michael Z. Green
Expanding The Ban On Forced Arbitration To Race Claims, Michael Z. Green
Faculty Scholarship
When Congress passed the Ending Forced Arbitration of Sexual Assault and Sexual Harassment Act (“EFASASHA”) in March 2022, it signaled a major retreat from the Supreme Court’s broad enforcement of agreements to force employees and consumers to arbitrate discrimination claims. But the failure to cover protected discriminatory classes other than sex, especially race, tempers any exuberance attributable to the passage of EFASASHA. This Article prescribes an approach for employees and consumers to rely upon EFASASHA as a tool to prevent both race and sex discrimination claims from being forced into arbitration by employers and companies. This approach relies upon procedural …
Using Imaging Modalities To Predict Nanoparticle Distribution And Treatment Efficacy In Solid Tumors: The Growing Role Of Ultrasound, Michaela B. Cooley, Dana Wegierak, Agata A. Exner
Using Imaging Modalities To Predict Nanoparticle Distribution And Treatment Efficacy In Solid Tumors: The Growing Role Of Ultrasound, Michaela B. Cooley, Dana Wegierak, Agata A. Exner
Faculty Scholarship
Nanomedicine in oncology has not had the success in clinical impact that was anticipated in the early stages of the field's development. Ideally, nanomedicines selectively accumulate in tumor tissue and reduce systemic side effects compared to traditional chemotherapeutics. However, this has been more successful in preclinical animal models than in humans. The causes of this failure to translate may be related to the intra- and inter-patient heterogeneity of the tumor microenvironment. Predicting whether a patient will respond positively to treatment prior to its initiation, through evaluation of characteristics like nanoparticle extravasation and retention potential in the tumor, may be a …