Digital Commons Network^™

Sensitivity Of Wavelet-Based Optical Flow Velocimetry (Wofv) To Common Experimental Error Sources, Bryan E. Schmidt, Gauresh Raj Jassal

Faculty Scholarship

The influence of several potential error sources and non-ideal experimental effects on the accuracy of a wavelet-based optical flow velocimetry (wOFV) method when applied to tracer particle images is evaluated using data from a series of synthetic flows. Out-of-plane particle displacements, severe image noise, laser sheet thickness reduction, and image intensity non-uniformity are shown to decrease the accuracy of wOFV in a similar manner to correlation-based particle image velocimetry (PIV). For the error sources tested, wOFV displays a similar or slightly increased sensitivity compared to PIV, but the wOFV results are still more accurate than PIV when the magnitude of …

Nanobubble Contrast Enhanced Ultrasound Imaging: A Review, Pinunta Nittayacharn, Felipe M. Berg, Dorian Durig, Agata A. Exner

Faculty Scholarship

Contrast-enhanced ultrasound is currently used worldwide with clinical indications in cardiology and radiology, and it continues to evolve and develop through innovative technological advancements. Clinically utilized contrast agents for ultrasound consist of hydrophobic gas microbubbles stabilized with a biocompatible shell. These agents are used commonly in echocardiography, with emerging applications in cancer diagnosis and therapy. Microbubbles are a blood pool agent with diameters between 1 and 10 μm, which precludes their use in other extravascular applications. To expand the potential use of contrast-enhanced ultrasound beyond intravascular applications, sub-micron agents, often called nanobubbles or ultra-fine bubbles, have recently emerged as a …

Trisc: Low-Cost Design Of Trigonometric Functions With Quasi Stochastic Computing, Mehran Shoushtari Moghadam, M. Hassan Najafi

Faculty Scholarship

Low-cost and hardware-efficient design of trigonometric functions is challenging. Stochastic computing (SC), an emerging computing model processing random bit-streams, offers promising solutions for this problem. The existing implementations, however, often overlook the importance of the data converters necessary to generate the needed bit-streams. While recent advancements in SC bit-stream generators focus on basic arithmetic operations such as multiplication and addition, energy-efficient SC design of non-linear functions demands attention to both the computation circuit and the bit-stream generator. This work introduces TriSC, a novel approach for SC-based design of trigonometric functions enjoying state-of-the-art (SOTA) quasi-random bit-streams. Unlike SOTA SC designs of …

The Role Of Accountability In Preserving Judicial Independence: Examining The Ethical Infrastructure Of The Federal Judicial Workplace, Susan Saab Fortney

Faculty Scholarship

After news reports of sexual harassment allegations involving federal judges, U.S. Supreme Court Chief Justice John Roberts asked the Director of the Administrative Office of the U.S. Courts to assemble a working group to address concerns related to misconduct in the federal judicial workplace. Following the working group’s report, the judiciary adopted recommendations relating to discrimination and harassment in the federal judiciary. Using the ethical infrastructure framework, this article reviews what changes have been made and what is missing. It explains how the steps taken largely focus on formal aspects of communicating and monitoring standards of conduct. Notably missing are …

Juror Privacy Via Anonymity, Jayne S. Ressler

Faculty Scholarship

No abstract provided.

Environmental Law In Trump’S Second Term, Michael B. Gerrard

Faculty Scholarship

Donald Trump’s victory in the Nov. 5, 2024 election and Republican control of both the Senate and the House (if that happens) will mean a reversal of much of the environmental progress under the Biden administration, just as the 2016 election reversed large parts of the Obama environmental legacy. However, rapid advances in the technology and economics of clean energy have created a momentum that can be slowed but not stopped. States can adopt their own stronger standards despite what happens in Washington, with a few exceptions, and can use their procurement power and their pension funds’ investment clout to …

Seeing The Whole Together Through Relational Mapping: A Method For Engaging In Complex Systems Change, John Paul Stephens

Faculty Scholarship

Complex global challenges cut across organizational and sectoral boundaries, increasing calls for holistic responses. Seeing the whole across diverse stakeholders is challenging for participants in complex systems, yet doing so is essential for engaging effectively in systems change. A promising new method known as relational mapping, based on relational coordination theory, has been used to facilitate complex systems change. Here, we propose that relational mapping can be applied to help participants (1) see the whole in relation to the parts, (2) share their explicit and tacit knowledge, (3) engage in dialogue across distinct perspectives supported by the map as a …

Low-Frequency Stimulation Of Corpus Callosum Suppresses Epileptiform Activity In The Cortex Through Γ-Aminobutyric Acid Type B Receptor And Slow Afterhyperpolarization-Mediated Reduction In Tissue Excitability, Nrupen Pakalapati, Chia Chu Chiang, Dominique M. Durand

Faculty Scholarship

Objective: Deep brain stimulation, particularly low-frequency stimulation (LFS) targeting fiber tracts, has emerged as a potential therapy for drug-resistant epilepsy (DRE) and for generalized epilepsy, both of which pose significant treatment challenges. LFS diffusely suppresses seizures in the cortex when applied to fiber tracts like the corpus callosum (CC). Nevertheless, the specific processes responsible for suppressing epileptic activity in the cortex induced by LFS remain unclear. This study investigates the mechanisms underlying the antiepileptic effect in the cortex of LFS of the CC in coronal rodent brain slices. Methods: An in vitro 4-aminopyridine (4-AP) seizure model of cortical seizures was …

Searching For The Radical Constitution, Robert L. Tsai

Faculty Scholarship

Due to its length and richness, The Constitutional Bind could be considered several books in one. It is a socialist critique of American political development that highlights the tradeoffs from incremental rather than transformational progress. It is also a partial intellectual history of radical and alternative constitutional theories marginalized by the set of ideas that came to rule. Finally, the book serves as an urgent plea for fellow citizens to give up the mesmerizing, yet frustratingly confining rhetoric of twentieth-century liberal constitutionalism.

Given Rana’s central objective of investigating the rise of the “creedal” approach to American constitutionalism, I believe it …

A Simple And Fast Optical Clearing Method For Whole-Mount Fluorescence In Situ Hybridization (Fish) Imaging, Junwoo Suh, Yehe Liu, Jordan Smith, Michiko Watanabe, Andrew M. Rollins, Michael W. Jenkins

Faculty Scholarship

We report a single-step optical clearing method that is compatible with RNA fluorescence in situ hybridization (FISH) imaging. We previously demonstrated microscopy imaging with immunohistochemistry and genetic reporters using a technique called lipid-preserving refractive index matching for prolonged imaging depth (LIMPID). Our protocol reliably produces high-resolution three-dimensional (3D) images with minimal aberrations using high magnification objectives, captures large field-of-view images of whole-mount tissues, and supports co-labeling with antibody and FISH probes. We also custom-designed FISH probes for quail embryos, demonstrating the ease of fabricating probes for use with less common animal models. Furthermore, we show high-quality 3D images using a …

Study Of Am Electrodeposition From Amcl₃-Licl-Kci Molten Salt, Rohan Akolkar, Christine E. Duval

Faculty Scholarship

In this work, the electrodeposition reaction of Am in AmCl₃LiCl-KCl molten salt was studied using voltammetry and chronoamperometry. Electrodeposition of Am was shown to proceed via a two − step reaction scheme, involving the one-electron transfer reduction of Am³⁺ to Am²⁺, followed by the two-electron transfer reduction of intermediate Am²⁺ to Am⁰. A low Coulombic efficiency of Am deposition was measured despite the Am deposition occurring within the thermodynamic stability window of the supporting LiCl-KCl electrolyte. We hypothesize that the low efficiency is due to out-diffusion of the intermediate Am²⁺ species away from the electrode surface. Experimental observations provide evidence …

Fail Fast, Fail Small: Designing Resilient Systems For The Future Of Software Engineering, Jill Willard, James Hutson

Faculty Scholarship

The principles of "fail fast, fail small" have emerged as critical in modern software and system design. By planning for minor, manageable failures instead of catastrophic breakdowns, developers can ensure that systems degrade gracefully, maintaining functionality even when encountering issues. This article delves into strategies for designing resilient systems, beginning with the concept of slow degradation and distributed systems that prioritize core functions while allowing non-critical components to fail without significant user impact. The Netflix recommendation engine serves as a prime example of a system that continues to operate under failure conditions. Chaos engineering, a proactive methodology for stress-testing system …

The False Choice Between Digital Regulation And Innovation, Anu Bradford

Faculty Scholarship

This Article challenges the common view that more stringent regulation of the digital economy inevitably compromises innovation and undermines technological progress. This view, vigorously advocated by the tech industry, has shaped the public discourse in the United States, where the country’s thriving tech economy is often associated with a staunch commitment to free markets. U.S. lawmakers have also traditionally embraced this perspective, which explains their hesitancy to regulate the tech industry to date. The European Union has chosen another path, regulating the digital economy with stringent data privacy, antitrust, content moderation, and other digital regulations designed to shape the evolution …

Taxing The Ten Percent, Alex Raskolnikov

Faculty Scholarship

The United States government is rapidly approaching the point when it will have no choice but to raise taxes. But whose taxes should go up, and why? The argument for higher taxes on the top one percent is well known. The case for higher taxes on the next nine percent is not. This Article makes that case.

Americans with incomes in the top ten percent but not the top one percent are not rich, but they are not middle class either—they are affluent. These affluent Americans have seen mostly tax cuts over the past three decades. Yet today, as progressive …

The International Legal Framework Of Oceanic Shipping Of Carbon Dioxide For Permanent Storage, Carolina Arlota, Michael B. Gerrard

Faculty Scholarship

The Intergovernmental Panel on Climate Change defines carbon dioxide capture and storage (CCS) as “a process in which a relatively pure stream of carbon dioxide (CO2) from industrial and energy-related sources is separated (captured), conditioned, compressed, and transported to a storage location for long-term isolation from the atmosphere.” Therefore, CCS encompasses a series of steps, at minimum: capturing carbon dioxide, its transportation to a storage site, and its injection into the subsurface for permanent storage. As such, CCS does not refer to any single activity or technology. This Article focuses on the transportation aspect of CCS and, more precisely, …

The Intangible Divide: Why Do So Few Firms Invest In Innovation?, James Bessen, Xiupeng Wang

Faculty Scholarship

Investments in software, R&D, and advertising have grown rapidly, now approaching half of U.S. private nonresidential investment. Yet just a few hundred firms account for almost all this growth. Most firms, including many large ones, regularly invest little in capitalized software and R&D, and this "intangible divide" has surprisingly deepened as intangible prices have fallen relative to other assets. Using comprehensive US Census microdata, we document these patterns and explore a variety of factors associated with intangible investment. We find that firms invest significantly less in innovation-related intangibles when their rivals invest more. One firm's investment can obsolesce rivals' investments, …

The 2023 Merger Guidelines: An Assessment, Herbert Hovenkamp, Tim Wu, James Keyte

Faculty Scholarship

The 2023 Merger Guidelines1 are ten months old, but they still need some unpacking. To help our readers think through the issues that the Guidelines raise, Antitrust magazine asked two experienced legal scholars — Professors Tim Wu and Herbert Hovenkamp — to discuss the Guidelines with Antitrust editorial board member James Keyte. This discussion took place on May 28, 2024. The transcript has been edited for length and readability.

Synergistic Effects Of Biological Stimuli And Flexion Induce Microcavities Promote Hypertrophy And Inhibit Chondrogenesis During In Vitro Culture Of Human Mesenchymal Stem Cell Aggregates, Bo Zhang, Jim Berilla, Sungwoo Cho, Rodrigo A. Somoza, Jean F. Welter, Harihara Baskaran

Faculty Scholarship

Interzone/cavitation are key steps in early stage joint formation that have not been successfully developed in vitro. Further, current models of endochondral ossification, an important step in early bone formation, lack key morphology morphological structures such as microcavities found during development in vivo. This is possibly due to the lack of appropriate strategies for incorporating chemical and mechanical stimuli that are thought to be involved in joint development. We designed a bioreactor system and investigated the synergic effect of chemical stimuli (chondrogenesis-inducing [CIM] and hypertrophy-inducing medium [HIM]) and mechanical stimuli (flexion) on the growth of human mesenchymal stem cells (hMSCs) …

Lamellipodia-Mediated Osteoblast Haptotaxis Guided By Fibronectin Ligand Concentrations On A Multiplex Chip, Xiaotian Feng, Seoyoung Jeong, Melissa L. Carr, Radhika P. Atit, Samuel E. Senyo

Faculty Scholarship

Skull morphogenesis is a complex, dynamic process involving two different germ layers and progressing to the coordinated, directional growth of individual bones. The mechanisms underlying directional growth toward the apex are not completely understood. Here, a microfluidic chip-based approach is utilized to test whether calvarial osteoblast progenitors undergo haptotaxis on a gradient of Fibronectin1 (FN1) via lamellipodia. Mimicking the embryonic cranial mesenchyme's FN1 pattern, FN1 gradients is established in the chip using computer modeling and fluorescent labeling. Primary mouse calvarial osteoblast progenitors are plated in the chip along an array of segmented gradients of adsorbed FN1. The study performs single-cell …

All You Need Is Unary: End-To-End Bit-Stream Processing In Hyperdimensional Computing, Mehran Shoushtari Moghadam, M. Hassan Najafi

Faculty Scholarship

Hyperdimensional Computing (HDC) is a brain-inspired computing paradigm introduced to achieve energy efficiency with a lightweight and single-pass training model. Hypervectors (HVs) at the heart of the HDC systems play a fundamental role in elevating the accuracy and obtaining the desired performance. Image-based HV encoding requires two types of HVs: Position and Level HVs. State-of-the-art approaches utilize pseudo-random methods for generating these HVs, which might degrade system performance and cause higher power consumption due to poor randomness in HV generation. These conventional methods require iteratively calculating orthogonal Positional HVs for acceptable accuracy. This work proposes a fast, ultra-lightweight, and high-quality …

Adaptive Worlds: Generative Ai In Game Design And Future Of Gaming, And Interactive Media, Jay Ratican, James Hutson

Faculty Scholarship

Generative AI is revolutionizing the field of game design, introducing unprecedented adaptability and personalization in gameplay. The latest advancements in AI-driven engines enable real-time content creation, offering dynamic, player-driven experiences that diverge from traditional pre-programmed narratives. This shift marks a transition toward "choose your own adventure" formats, with an unlimited number of variations in levels, enemies, collectibles, and weaponry, tailored to each player's decisions. Google's GameNGen, for example, showcases AI's capacity to recreate classic games like DOOM, learning and generating gameplay in real time. These innovations are not restricted to gaming alone; they extend to edutainment, television, and film, where …

Physiological Role For S-Nitrosylation Of Ryr1 In Skeletal Muscle Function And Development, Qi-An Sun, Zachary W. Grimmett, Douglas T. Hess, Zhaoxia Qian, Ruchi Chaube, Nicholas M. Venetos, Bradley N. Plummer, Kenneth R. Laurita, Richard T. Premont, Jonathan S. Stamler

Faculty Scholarship

Excitation-contraction coupling in skeletal muscle myofibers depends upon Ca2+ release from the sarcoplasmic reticulum through the ryanodine receptor/Ca2+-release channel RyR1. The RyR1 contains ∼100 Cys thiols of which ∼30 comprise an allosteric network subject to posttranslational modification by S-nitrosylation, S-palmitoylation and S-oxidation. However, the role and function of these modifications is not understood. Although aberrant S-nitrosylation of multiple unidentified sites has been associated with dystrophic diseases, malignant hyperthermia and other myopathic syndromes, S-nitrosylation in physiological situations is reportedly specific to a single (1 of ∼100) Cys in RyR1, Cys3636 in a manner gated by pO2. Using mice expressing a form …

Navigating Life: Neuroscience And Inclusive Design In Wayfinding Systems, Stephanie Jost, Piper Hutson, James Hutson

Faculty Scholarship

Wayfinding, as conceptualized by Lynch, has transformed from traditional navigation methods reliant on visual cues and landmarks to modern systems that integrate digital technologies and neuroscience. This study addresses the need for accessible and consistent wayfinding systems that accommodate diverse user abilities, particularly in complex environments such as public transit, hospitals, and large institutions. Current systems often lack coordination, clear signage, and comprehensive coverage, leading to navigation challenges. Through a multi-method approach, including literature review and case study analysis, this research evaluates best practices for inclusive wayfinding. Key findings emphasize the importance of consistent visual design, strategic sign placement, and …

Impact Of Resin Molecular Weight On Drying Kinetics And Sag Of Coatings, Marola W. Issa, Christpher L. Wirth

Faculty Scholarship

Coating performance is influenced by factors inherent to formulation design and processing conditions. Understanding the complex interplay of these attributes enables for mitigating defects, such as sag, which is a gravity-driven phenomenon that impacts the aesthetic and functionality of a coating. The work herein investigates the impact of resin molecular weight and solvent choice on the drying kinetics and sag velocity in polymer films. These films, ranging in thickness from ~60 μm to ~120 μm were formulated with 45 % by weight polymer resin in one of two solvent packages with different relative evaporation rates (RER). Gravimetry was initially used …

Satirical Deepfakes, Surreal Dreamscapes & Nostalgic Pixels: The Rapid Evolution And Cultural Commentary Of Ai-Aesthetics, Andrew Smith, James Hutson

Faculty Scholarship

The rapid evolution of visual aesthetics driven by AI, shared globally through the internet and social media, has dramatically accelerated what once took centuries to develop. This article explores the unique visual tropes emerging from AI-generated content, characterized by surreal, uncanny, and often unsettling imagery. Examples range from the Dor Brothers' stylized narrative videos to horrifying depictions of transformations, such as people morphing into motorcycles. The article contextualizes this aesthetic within historical developments in creative experimentation, drawing parallels with David Bowie's unconventional approach to sound creation in the 1970s. It also considers how AI-driven art, free from copyright constraints in …

Ai Satire And Digital Dystopia: The Dor Brothers Crafting Imperfection And Political Commentary In Contemporary Video Art, James Hutson, Andrew Smith

Faculty Scholarship

The Dor Brothers' AI-generated video content exemplifies an inflection point in digital creativity, where technological limitations are repurposed as aesthetic tools. Drawing on recent interviews with Yonatan Dor, this article explores the innovative techniques of the brothers, such as masking visual imperfections with retro filters and embracing the unpredictability of AI outputs. Through generating numerous clips and meticulously editing selections, they create a unique aesthetic that juxtaposes surrealism with a gritty realism, often reminiscent of early CCTV or VHS footage. Their work not only transcends the typical "morphing face" trope of AI videos but also engages in satire, using deepfake-like …

Contemplating Existence: Ai And The Meaning Of Life, Emily Barnes, James Hutson

Faculty Scholarship

This article explores the intersection of artificial intelligence (AI) with existential philosophy, examining how AI technologies influence human conceptualizations of purpose and meaning. Despite rapid advancements in AI, the domain's implications for existential thought remain underexplored. By integrating interdisciplinary perspectives from psychology, philosophy, and AI ethics, this study elucidates how AI can shape, challenge, or enhance our understanding of life's purpose. It investigates theoretical frameworks and practical implementations of AI engaging in existential questions, analyzing both the capabilities and limitations of AI systems such as ChatGPT in simulating human existential thought. The ethical implications of AI's role in existential inquiries …

Prudence, Role Morality, And Restraint: Judge Wilkinson On The Separation Of Powers, Katherine Mims Crocker, Jack Goldsmith

Faculty Scholarship

Caution in reviewing the actions of the legislative and executive branches has been a hallmark of the jurisprudence of Judge J. Harvie Wilkinson III. The Constitution “at most gives judges specific authority to redress violations of specific provisions,” Judge Wilkinson writes in his book Cosmic Constitutional Theory. But even when doing so, “courts must exercise great caution before injecting themselves into the vortex of varied political questions,” for “[i]t is often far preferable to allow the political institutions under our Constitution to struggle among themselves, with each bringing to bear the respective arsenal of powers the Framers accorded them.” …

Enhancing History Education With Google Notebooklm: Case Study Of Mary Easton Sibley’S Diary For Multimedia Content And Podcast Creation, Paul Huffman, James Hutson

Faculty Scholarship

This article explores new features of Google’s NotebookLM, an AI-powered tool designed for advanced document analysis and educational content generation. Tested on the 92-page transcribed diary of Mary Easton Sibley, the founder of Lindenwood University, NotebookLM effectively generated FAQs, a study guide, a table of contents, a briefing document, and an audio overview in podcast format. By transforming static historical documents into dynamic learning materials, the document-based AI model provides a user-friendly interface for educators and students, especially those without experience in audio editing or podcasting. While successful in creating study guides and audio formats, the tool faced challenges in …

The Surprising Survival – So Far – Of The Corporate Contribution Ban, Richard Briffault

Faculty Scholarship

In Citizens United v. Federal Election Commission, the Supreme Court invalidated the longstanding ban on the expenditure of corporate funds in federal election campaigns. In so doing, the Court dismissed outright an argument that had long been the foundation for the restriction of corporate money in election campaigns — that, due to the “substantial aggregations of wealth amassed by the special advantages which go with the corporate form[,]” corporate money poses a distinct threat to the integrity of democracy. Instead, viewing corporations as essentially “associations of citizens,” Citizens United determined that “the First Amendment does not permit Congress to …