Digital Commons Network^™

Examining The Effects Of Mental Health And Parent–Youth Relationship On The Associations Between Childhood Violence Exposure And Adolescent Dating Violence Perpetration, Laura A. Voith

Faculty Scholarship

Background/objectives: Adolescent dating violence (ADV) is a serious public health concern affecting youth worldwide. Potential risk factors of ADV include child maltreatment (CM) and intimate partner violence exposure (eIPV), though existing research on ADV perpetration specifically is inconsistent. There is limited research on co-occurring eIPV and CM, despite co-occurrence in 30–60% of homes where there is one. This study aims to address these gaps by testing the impact of childhood violence exposure on ADV perpetration and assessing two potential, theory-informed mitigating factors—mental health and parent–youth relationship. Methods: This study utilizes moderated-mediation structural equation modeling with longitudinal data from a sample …

Apolipoprotein E (Apoe) And Alzheimer's Disease Risk In A Ugandan Population: A Pilot Case-Control Study, Martha Sajatovic

Faculty Scholarship

Alzheimer's disease (AD) is a neurodegenerative disorder that is characterized by cognitive decline and progressive functional impairment. The Apolipoprotein E (APOE) gene, particularly its ϵ2, ϵ3, and ϵ4 alleles, plays a crucial role in lipid metabolism, and has been implicated in AD pathogenesis. Although the APOE ϵ4 status is associated with an increased risk of AD, its impact varies across populations. This study investigated the prevalence of and association between APOE alleles and AD risk in a Ugandan cohort. This case-control study was conducted in Uganda, and included 87 participants (45 patients with AD and 42 healthy controls). Cognitive assessment …

On Metric Choice In Dimension Reduction For Fréchet Regression, Abdul Nasah Soale, Congli Ma, Siyu Chen

Faculty Scholarship

Fréchet regression is becoming a mainstay in modern data analysis for analysing non-traditional data types belonging to general metric spaces. This novel regression method is especially useful in the analysis of complex health data such as continuous monitoring and imaging data. Fréchet regression utilises the pairwise distances between the random objects, which makes the choice of metric crucial in the estimation. In this paper, existing dimension reduction methods for Fréchet regression are reviewed, and the effect of metric choice on the estimation of the dimension reduction subspace is explored for the regression between random responses and Euclidean predictors. An extensive …

Predicting Sorption Of Diverse Organic Compounds In Soil-Water Systems: Meta-Analysis, Machine Learning Modeling, And Global Soil Mapping, Jiachun Sun, Kai Zhang, Huichun Zhang

Faculty Scholarship

In recent decades, the environmental detection of various organic compounds (OCs) has highlighted the limitations of conventional soil-water sorption models, which simplify complex experimental conditions and often overlook OCs with polyfunctional and ionizable structures. To address these shortcomings, we compiled a comprehensive soil-water sorption dataset encompassing 20,945 data points for 419 OCs with various functional groups and 1037 different soils. Meta-analysis of the dataset revealed the trends of soil sorption associated with OC substructures, soil properties, and solution conditions. Machine learning models employing the XGBoost algorithm, in conjunction with MACCS fingerprints and experimental conditions, were developed to cover the entire …

Tnf-Α-Driven Changes In Polarized Egf Receptor Trafficking Facilitate Phosphatidylinositol 3-Kinase/Protein Kinase B Signaling From The Apical Surface Of Mdck Epithelial Cells, Syntyche Ngalula, Cathleen R. Carlin

Faculty Scholarship

This manuscript describes a novel unconventional secretory pathway that facilitates EGF receptor (EGFR) signaling from apical membranes in polarized epithelial cells responding to immune cell mediators. Epithelial tissues provide a physical barrier between our bodies and the external environment and share an intimate relationship with circulating and local immune cells. Our studies describe an unexpected connection between the proinflammatory cytokine tumor necrosis factor-alpha (TNF-α) and EGFR typically localized to basolateral membranes in polarized epithelial cells. These two molecules sit atop complex biological networks with a long history of shared investigative interest from the vantage point of signaling pathway interactions. We …

The Rising Returns To R&D: Ideas Are Not Getting Harder To Find, Yoshiki Ando, James Bessen, Xiupeng Wang

Faculty Scholarship

R&D investment has grown robustly, yet aggregate productivity growth has stagnated. Is this because “ideas are getting harder to find”? This paper uses micro-data from the US Census Bureau to explore the relationship between R&D and productivity in the manufacturing sector from 1976 to 2018. We find that both the elasticity of output (TFP) with respect to R&D and the marginal returns to R&D have risen sharply. Exploring factors affecting returns, we conclude that R&D obsolescence rates must have risen. Using a novel estimation approach, we find consistent evidence of sharply rising technological rivalry. These findings suggest that R&D has …

The Built Environment And Adverse Cardiovascular Events In Us Veterans With Cardiovascular Disease, Skanda Moorthy, Zhuo Chen, Tong Zhang, Sai Rahul Ponnana, Santosh Kumar Sirasapalli, Kanimozhi Shivanantham, Haitham Khraishah, Jean Eudes Dazard, Sadeer G. Al-Kindi, Salil V. Deo, Sanjay Rajagopalan

Faculty Scholarship

Question: Can AI-extracted interpretable built environment features predict major adverse cardiovascular events (MACE) in a national veteran population? Findings: In this cohort study of 770,990 U.S. veterans, seven built environment features were significantly associated with an increased risk of MACE. Two features, old/dilapidated buildings and visible wire, were associated with a decreased risk. Greenery was only linked to increased risk in higher social deprivation index quartiles. Meaning: Built environment features can serve as predictors of MACE, highlighting the potential role of neighborhood characteristics in cardiovascular risk stratification beyond traditional factors. Importance: The relationship between built environment features and major adverse …

Role Of Fluid-Structure Interactions In Mechanosensation During Hovering Flapping Flight, Menglong Lei, Chengyu Li

Faculty Scholarship

Insect wings, known for their intricate structure and function, inherently deform during flapping motion. These deformations can be classified into chordwise cambering, spanwise bending, and root-to-tip twisting, arising from non-uniform venation distribution, aerodynamic loading, and wing inertia. Crucially, such deformations play a vital role in enhancing both aerodynamic performance and mechanosensory function. To investigate the complex interplay between wing structure, unsteady aerodynamics, and mechanosensation, we developed a fully coupled three-dimensional fluid-structure interaction (FSI) solver. This framework integrates an in-house Navier-Stokes equations solver for resolving the flow field with the open-source Vega FEM code to solve the solid structure dynamics. Our …

A Continuous-Heat-Flux Phase Change Model For Simulating Realistic Two-Phase Unsaturated Evaporation Processes, Thanh Hoang Phan, Cho Ning Huang, Chirag R. Kharangate

Faculty Scholarship

Accurately modeling liquid-vapor mass transfer rates is essential for optimizing cryogenic fluid management processes critical to advancing future space missions. This study introduces a continuous-heat-flux phase change model proposed to simulate conditions observed in realistic two-phase unsaturated evaporation phenomena. The mass transfer rate across the two-phase interface is calculated directly based on the local interfacial continuous heat flux on both liquid and vapor phases, effectively accounting for superheated, saturated, and subcooled liquid effects without requiring any empirical tuning parameters. Moreover, phase change occurs exclusively within interfacial cells, ensuring the sharp representation of deformed evaporating interfaces with high accuracy. The proposed …

Letter To The Fda Proposing Major Changes In The Us Clozapine Package Insert Supported By Clozapine Experts Worldwide. Part Ii A Review Of Fatal Outcomes In Us Pharmacovigilance Data And Proposed Changes, Martha Sajatovic

Faculty Scholarship

Purpose/Background: This is the second part of a 2-part article that proposes improving the United States (US) clozapine package insert. Part II focuses on fatal outcomes and the 5 boxed warnings, 4 specifically for clozapine: severe neutropenia, seizure, orthostatic hypotension and myocarditis, and 1 for all antipsychotics (elderly with dementia). Methods: US reports to the World Health Organization's global pharmacovigilance database were analyzed from clozapine's introduction to January 15, 2023. Findings/Results: The US was the top reporter worldwide for clozapine with 56,003 reports and 9587 associated fatal outcomes. The 4 clozapine boxed warnings were associated with 534 fatal outcomes (218 …

Pv Backsheets Survey Protocol: A Framework For Geo-Spatial Field Surveys For Bulk Material Characterization And Reliability Analysis Applied Across 41 Pv Systems, Raymond J. Wieser, Zelin Li, Xuanji Yu, Laura S. Bruckman

Faculty Scholarship

As widespread adoption of photovoltaic (PV) technologies continues, understanding the lifetime of modules is paramount to the viability of the industry as an environmentally conscious alternative to traditional energy generation. Although power degradation can affect the total energy production of a module over its lifetime, module safety failures necessitate the removal of a module leading to a loss of not only the particular asset, but the earning potential of the device. Therefore, it is critical to ensure that the components that provide essential safety functions for PV module operate for their entire rated lifetime. PV backsheets provide necessary electrical insulation …

Building Layered Defenses To Reduce Illegal Gun Violence, Samuel Kan

Faculty Scholarship

This article examines a multifaceted approach to reducing illegal gun violence in the United States through the implementation of layered defense strategies. While acknowledging the constitutional protections afforded by the Second Amendment, the author argues that targeted legislative and community-based interventions can effectively reduce gun violence without infringing on lawful gun ownership rights. The analysis explores several key defensive measures, including extreme risk laws (risk protection orders), which allow for temporary firearm removal from individuals posing credible threats to themselves or others—a practice recently upheld by the Supreme Court in United States v. Rahimi. The article further examines the constitutional …

The 100-Year Life And The New Family Law, Naomi Cahn, Clare Huntington, Elizabeth S. Scott

Faculty Scholarship

This chapter reflects on the future of family law in an era of longer lives. Our analysis leads us to conclude that the 100-year life is indeed likely to have an impact on the nature, scope, and definition of family law, but that families will continue to function as the primary setting for intimacy and for caregiving and caretaking, whatever form those families take. Further, the importance to both individual and social welfare of family support throughout life points to a need for reform of current family law doctrine. The impact of longer life on doctrines regulating the relationship of …

Administrative Law And The Pandemic, Gillian E. Metzger

Faculty Scholarship

American administrative law’s relationship to change is, as they say, compli­cated. On the one hand, continual evolution has been an endemic feature of American administrative law. Doctrines such as Chevron deference to agency statutory interpretations were born, grew, and declined in just the period from the 1980s to today. On the other, the United States (US) Supreme Court regularly rejects such common law development in administrative law as illegitimate and insists that federal judges must adhere to the original terms of the 1946 Administrative Procedure Act (APA) and other statutes, unless the Constitution requires otherwise. And to this day scholars …

1785 Parisian Salon Project: New Methods And Practical Innovations In Digital Heritage Reconstruction, James Hutson, Charles O'Brien, Wesley Wolfe, Kayla Kraff, Trent Olsen

Faculty Scholarship

The 1785 Salon Unreal Engine Reconstruction Project represents a significant advance in digital heritage and immersive art historical research by combining generative AI-based asset creation, modular user experience (UX) design, and historically informed workflows. During the Spring 2025 phase, the project achieved major milestones, including the successful development of a replicable pipeline for transforming 2D reference images into period-accurate 3D sculpture models using generative AI and digital sculpting tools. Simultaneously, a robust and adaptable Inspection System was engineered within Unreal Engine, offering granular interaction controls, bilingual (English/French) content integration, dynamic metadata display, and enhanced accessibility. These innovations collectively enabled historically …

Deepfakes In Domestic And International Perspective, Jane C. Ginsburg, Graeme W. Austin

Faculty Scholarship

Have you always (or ever) yearned to produce your own recording of Elvis Presley singing great baritone arias from Italian opera? Or to make a movie starring Nicole Kidman as Lady Macbeth? Or a videogame featuring the bully who tormented you in high school suffering repeated tortures worthy of the Christian martyrdoms recounted with gusto in The Golden Legend? You can fulfill all these wishes, and more, thanks to the AI technology enabling the creation of “deepfakes” — known in legal documents as “digital replicas” — capable of simulating the visual and vocal appearance of real people, living or …

Letter To The Fda Proposing Major Changes In The Us Clozapine Package Insert Supported By Clozapine Experts Worldwide. Part I A Review Of The Pharmacokinetic Literature And Proposed Changes, Martha Sajatovic

Faculty Scholarship

Purpose/Background: Clozapine was approved in the United States (US) using 1989 regulations and knowledge. After 30 years, many sections of the US package insert (PI) are outdated. Methods: We comprehensively reviewed the literature to propose PI updates. We present the information in 2 articles. In Part I, we focus on basic pharmacology based on 407 relevant articles. Part II focuses on clinical aspects and pharmacovigilance. Findings/Results: Based on more recent expectations of Food and Drug Administration regulations, we reviewed clozapine basic pharmacology including the following: 1) clearance, 2) pharmacokinetics and pharmacodynamics, and 3) monitoring tools. We identified 9 major problems …

The Right To Grow Old, Jamal Greene

Faculty Scholarship

This chapter considers the status of a constitutional “right to grow old” under the US Constitution. Understood as a “positive” right – ensuring a certain minimum quality of life to people as they face the challenges of aging – such a right may seem unavailing given the austerity in respect to such rights that many lawyers associate with the US constitutional tradition. This chapter shows this view to be premature, at least. Unlike the kinds of positive rights overtly rejected in prior cases, such as rights to certain forms of social welfare or to racial equality, a right to grow …

Constraining The Family Regulation System: The Contribution Of The Restatement Of The Law, Children And The Law, Clare Huntington

Faculty Scholarship

Advocates, policymakers, and scholars have argued for years that the family regulation system (also known as the child welfare system) fails families. Critics rightly note that the system does far too little to support families proactively and does not address the poverty and structural racism underlying many allegations of child abuse and neglect. The overrepresentation of Black, Native American, and Native Alaskan children in foster care is a stark and disturbing manifestation of these failings.

In response to these concerns, there is an active debate about abolishing or radically reforming the family regulation system to direct government funding to proactive …

Simulating Chill: Exploring The Cognitive And Therapeutic Potential Of Cold Vr Environments, Jessica Turner, Piper Hutson, James Hutson

Faculty Scholarship

This study investigates the cognitive and therapeutic potential of immersive virtual reality (VR) environments designed to simulate cold conditions. Through the engagement of participants through multisensory stimuli—including vivid visual representations of the Athabasca Glacier, auditory effects of icy winds, and corresponding haptic feedback—the research evaluates neurological and physiological responses associated with attention, emotional regulation, and stress modulation. Participants experienced virtual scenarios featuring icy winds and snow, activating specific neurological pathways involving the occipital lobe, primary visual cortex, superior colliculus, and insula, thus reinforcing sensory integration. Through predictive coding, the anterior insula and hypothalamus were engaged, prompting thermoregulatory simulations and subconscious …

The "Not Seen" Effect Of International Financial Centers: Innovation In The Global Financial Ecosystem, Charlotte Ku, Andrew P. Morriss

Faculty Scholarship

International Financial Centers (IFCs) are hubs of legal and financial innovation, developing specialized frameworks that facilitate cross-border investment, enhance global capital mobility, and support economic growth. Through jurisdictional competition, professional clustering, and adaptive regulatory frameworks, IFCs have pioneered legal structures that enable enterprises of all sizes to participate in the global economy. Using case studies of the International Business Company, the Limited Liability Company, the Protected Cell Company, and advances in trust law and applying the theoretical frameworks of social scientist Richard Florida and psychologist Mihalyi Csikszentmihalyi, this Article illustrates how IFCs serve as laboratories for financial experimentation, generating widely …

Antiracist Expert Evidence, Jasmine Gonzales Rose, Asees Bhasin, Spencer Piston

Faculty Scholarship

Since 2020, when mass protests against racism swept across the United States, scholars, lawyers, and the general public have become increasingly aware that racism permeates society and the criminal legal system, from overt racial animus to the nuanced effects of structural racism. Demonstrating the influence of racism is therefore vital to the practice of criminal defense, yet many attorneys do not know how to prove racism in court. We surveyed over seven hundred criminal-defense attorneys across the United States, and nearly half had never heard of expert witnesses testifying or submitting written reports on racism—what we call “antiracist expert evidence.” …

Restating The Law Of Children And Youth: The Evolution Of Reform, Elizabeth S. Scott

Faculty Scholarship

A brief roadmap of this article may be helpful. Part I describes the emergence of the Child Wellbeing framework and its powerful role in shaping twenty-first-century youth justice reforms captured by the Restatement. Part II shows how this framework has begun to have a far broader influence on the law affecting children and how the framework and the developmental approach embodied in the Restatement can guide courts and shape the trajectory of the law in the future. Part III explores potential challenges to the Restatement’s effectiveness in attaining a fully integrated system based on the Child Wellbeing framework.

Eviction Sealing: A Lifeline In The Fight For Housing Justice, Allison Freedman

Faculty Scholarship

In January 2023, the White House released a Blueprint for a Renters Bill of Rights. The Blueprint called for immediate sealing of eviction case filings to reduce the likelihood that tenants would be locked out of future housing opportunities without the chance to defend themselves. Shortly thereafter, the Federal Trade Commission and the Consumer Financial Protection Bureau issued a request for public comment on how the use of eviction records and screening algorithms may affect tenant housing opportunities and drive discriminatory outcomes. The eviction crisis, its discriminatory effects, and the idea that sealing eviction records may provide a solution to …

Neuroarts And Neuroaesthetics, James Hutson, Piper Hutson

Faculty Scholarship

Recent advancements in neuroarts and neuroaesthetics have elucidated the relationship between artistic engagement and neural processes, emphasizing the impact of aesthetic experiences on cognitive and emotional well-being. Central to this exploration is the NeuroArts Blueprint initiative, which consolidates interdisciplinary research to better understand the impactful role of the arts on brain function and health outcomes. Empirical studies highlight how exposure to art, such as music or visual stimuli, activates neural circuits involved in emotion regulation, memory, and reward processing, particularly engaging the medial orbitofrontal cortex. Innovations such as haptic and electro-tactile devices have introduced novel sensory modalities that not only …

Capturing Interfacial Phase Change And Flow Physics During Vertical Downflow Condensation, Thanh Hoang Phan, Cho Ning Huang, Chirag R. Kharangate

Faculty Scholarship

Two-phase configurations can address the urgent demand for effective heat dissipation solutions in Naval power and energy systems. A better understanding of thermal transport processes in phase-change flows is critical for developing novel two-phase design tools for naval scientists and engineers. This study investigates interfacial phase change and flow dynamics during condensation flow through numerical simulations. An enhanced phase change model, incorporating a mass transfer intensity coefficient dependent on condensation film thickness, is implemented for vertical downflow condensation. A two-dimensional homogeneous two-phase Reynolds-Averaged Navier-Stokes model, coupled with the Shear-Stress Transport k-ω turbulence model, is employed. The developed solver is thoroughly …

Politics And Collection Development: Behaviors In Library Collecting Based On Political Climates, Zachary G. Stein, Lindsey M. Reno

Faculty Scholarship

Over the last several years libraries in the United States have dealt with an increasing number of book challenges and calls for censorship of materials. The challenges and calls for censorship are no longer only from library patrons, but now include national organizations and even local and state legislators. Some of these actions have moved to criminalize librarians and curtail first amendment rights. Due to this new climate, it is important to examine the effect these culture wars have on library collection development decisions. This quantitative study seeks to answer that question with a nationwide survey of library professionals.

Evaluation Of Objective Methods For Analyzing Ipsilateral Motor Evoked Potentials In Stroke Survivors With Chronic Upper Extremity Motor Impairment, Xin Li, Jayme S. Knutson, Xiaofeng Wang, Ken Uchino, Ela B. Plow, David A. Cunningham

Faculty Scholarship

Objective. Ipsilateral motor evoked potentials (iMEPs) are believed to represent cortically evoked excitability of uncrossed brainstem-mediated pathways. In the event of extensive injury to (crossed) corticospinal pathways, which can occur following a stroke, uncrossed ipsilateral pathways may serve as an alternate resource to support the recovery of the paretic limb. However, iMEPs, even in neurally intact people, can be small, infrequent, and noisy, so discerning them in stroke survivors is very challenging. This study aimed to investigate the inter-rater reliability of iMEP features (presence/absence, amplitude, area, onset, and offset) to evaluate the reliability of existing methods for objectively analyzing iMEPs …

Characterization Of The Gut Microbiome In Alzheimer Disease And Mild Cognitive Impairment Among Older Adults In Uganda: A Case-Control Study, Martha Sajatovic, Scott M. Williams

Faculty Scholarship

Alzheimer disease (AD) is associated with significant shifts in the gut microbiome and is characterized by reduced microbial diversity and changes in the abundance of specific taxa. These alterations can disrupt the gut-brain axis, leading to increased intestinal permeability ("leaky gut"), systemic inflammation, and oxidative stress. Such microbial changes are thought to contribute to neurodegenerative changes, as observed in AD and cognitive decline, thus emphasizing the role of the microbiome in aging-related neurological health. Our study in urban and rural population in Uganda recruited 104 participants aged 60 years and older, categorized into AD, mild cognitive impairment (MCI), and control …

Materials Data Science Ontology(Mds-Onto): Unifying Domain Knowledge In Materials And Applied Data Science, Balashanmuga Priyan Rajamohan, Alexander C. Harding Bradley, Van D. Tran, Jonathan E. Gordon, Hayden W. Caldwell, Redad Mehdi, Gabriel Ponon, Quynh D. Tran, Ozan Dernek, Benjamin G. Pierce, Raymond Wieser, Weiqi Yue, Kiefer Lin, Jiana Kambo, Arafath Nihar, Pawan K. Tripathi, Yinghui Wu, Laura S. Bruckman, Erika I. Barcelos, Roger H. French

Faculty Scholarship

Ontologies have gained popularity in the scientific community as a way to standardize terminologies in organizations’ data. Although certain cohorts have created frameworks with rules and guidelines on creating ontologies, there exist significant variations in how Materials Science ontologies are currently developed. We seek to provide guidance in the form of a unified automated framework for developing interoperable and modular ontologies for Materials Data Science that simplifies the ontology terms matching by establishing a semantic bridge up to the Basic Formal Ontology(BFO). This framework provides key recommendations on how ontologies should be positioned within the semantic web, what knowledge representation …