Digital Commons Network^™

Lgd-4033 And Mk-677 Use Impacts Body Composition, Circulating Biomarkers, And Skeletal Muscle Androgenic Hormone And Receptor Content: A Case Report, Thomas D. Cardaci, Steven B. Machek, Dylan T. Wilburn, Jeffrey L. Heileson, Dillon R. Harris, Harry P. Cintineo, Darryn S. Willoughby

Faculty Scholarship

LGD-4033, a selective androgen receptor modulator, and MK-677, a growth hormone secretagogue, are becoming increasingly used amongst recreationally-active demographics. However, limited data exist describing their effects on health- and androgen-related biomarkers. The purpose of this case study is to report changes in body composition and biomarkers during and after continued co-administration of LGD-4033 and MK-677. We additionally aimed to examine muscular strength and intramuscular androgen-associated biomarkers relative to non-users. A 25-year-old male ingested LGD-4033 [10 mg] and MK-677 [15 mg] daily for 5 weeks. Blood and body composition metrics were obtained pre-, on-, and post-cycle. One repetition maximum (1RM) leg …

The Impact Of Obesity And Adipokines On Breast And Gynecologic Malignancies, Surabhi Tewari, Roberto Vargas, Ofer Reizes

Faculty Scholarship

The link between obesity and multiple disease comorbidities is well established. In 2003, Calle and colleagues presented the relationship between obesity and several cancer types, including breast, ovarian, and endometrial malignancies. Nearly, 20% of cancer-related deaths in females can be accounted for by obesity. Identifying obesity as a risk factor for cancer led to a focus on the role of fat-secreted cytokines, known as adipokines, on carcinogenesis and tumor progression. Early studies indicated that the adipokine leptin increases cell proliferation, invasion, and inhibition of apoptosis in multiple cancer types. As a greater appreciation of the obesity–cancer link has amassed, we …

Aster La Vista: Unraveling The Biochemical Basis Of Carotenoid Homeostasis In The Human Retina, Sepalika Swarnamali Bandara Bathana Mudiyanselage, Johannes Von Lintig

Faculty Scholarship

Carotenoids play pivotal roles in vision as light filters and precursor of chromophore. Many vertebrates also display the colorful pigments as ornaments in bare skin parts and feathers. Proteins involved in the transport and metabolism of these lipids have been identified including class B scavenger receptors and carotenoid cleavage dioxygenases. Recent research implicates members of the Aster protein family, also known as GRAM domain-containing (GRAMD), in carotenoid metabolism. These multi-domain proteins facilitate the intracellular movement of carotenoids from their site of cellular uptake by scavenger receptors to the site of their metabolic processing by carotenoid cleavage dioxygenases. We provide a …

Screening Families In Primary Care For Social And Economic Needs: Patients’ Urgency And Activation For Social Care Navigation, Sarah D. Ronis, Marie Masotya, Kurt C. Stange

Faculty Scholarship

Introduction: Social determinants of health (SDoH) screening and intervention in primary care aim to alleviate adverse influences on health, but its efficacy may be diluted when offered supports are not well matched to families’ desire for such services. The purpose of this prospective cohort study was to provide guidance to social care navigation teams regarding which families would be most likely to make use of services. Methods: Analysis of registry data collected in April 1–September 30, 2021 from a social care navigation program embedded in a medical home was conducted. Multivariable regression models explored (1) whether family-reported urgency of needs, …

Combinations Of Chronic Conditions, Functional Limitations And Geriatric Syndromes Associated With Periodontal Disease, Hussam M. Alqahtani, Siran M. Koroukian, Kurt C. Stange, Nabil F. Bissada, Nicholas K. Schiltz

Faculty Scholarship

Objective To identify complex multimorbid conditions, including chronic conditions, functional limitations and geriatric syndromes, associated with the presence and severity of periodontal disease (PD), after accounting for a series of demographic and behavioural characteristics. Design This cross-sectional study used secondary data from a nationally representative sample, classification and regression tree analysis and random forest identified combinations of specific conditions constituting complex multimorbidity associated with the presence and severity of PD. Setting US National Health and Nutritional Examination Survey (2013-2014). Participants Individuals 60 years of age or older who completed a periodontal examination. Results Among 937 participants aged 60 and over, …

Update On The Management Of Vitamins And Minerals In Cystic Fibrosis, Senthilkumar Sankararaman

Faculty Scholarship

Advancements in respiratory and nutrition management have significantly improved the survival of patients with cystic fibrosis (CF). With the availability of several nutrition interventions such as oral/enteral nutrition supplements, enteric-coated pancreatic enzymes, and water-miscible CF-specific vitamin supplements, frank vitamin deficiencies—with the exception of vitamin D—are rarely encountered in current clinical practice. Whereas they were previously considered as micronutrients, our current understanding of fat-soluble vitamins and minerals as antioxidants, immunomodulators, and disease biomarkers has been evolving. The impact of highly effective modulators on the micronutrient status of patients with CF remains elusive. This narrative review focuses on the updates on the …

Temporal And Sex-Linked Protein Expression Dynamics In A Familial Model Of Alzheimer's Disease, Filipa Blasco Tavares Pereira Lopes, Daniela M. Schlatzer, Rihua Wang, Xiaolin Li, Emily Feng, Mehmet Koyutürk, Xin Qi, Mark R. Chance

Faculty Scholarship

Mouse models of Alzheimer's disease (AD) show progression through stages reflective of human pathology. Proteomics identification of temporal and sex-linked factors driving AD-related pathways can be used to dissect initiating and propagating events of AD stages to develop biomarkers or design interventions. In the present study, we conducted label-free proteome measurements of mouse hippocampus tissue with variables of time (3, 6, and 9 months), genetic background (5XFAD versus WT), and sex (equal males and females). These time points are associated with well-defined phenotypes with respect to the following: Aβ42 plaque deposition, memory deficits, and neuronal loss, allowing correlation of proteome-based …

Pathways From Exposure To Community Violence To Bullying Victimization Among African American Adolescents In Chicago’S Southside, Dexter R. Voisin

Faculty Scholarship

The present study proposes and examines the pathways from exposure to community violence to bullying victimization through the influences of depression, exposure to peer delinquency, and drug use among 638 African American adolescents (aged 12–22) from low-resourced neighborhoods in Chicago’s Southside. The study found that African American adolescents who were exposed to community violence were likely at risk of bullying victimization, depression, exposure to peer delinquency, and drug use. Depression can heighten the risk of bullying victimization. These findings have implications for future research.

Riverine Plastic Pollution In Asia: Results From A Bibliometric Assessment, Peter Yang

Faculty Scholarship

Rivers are important ecosystems, vital to the livelihoods of hundreds of millions of humans and other species. Despite their environmental, social, and economic importance, current use of rivers is unsustainable, due to a combination of solid waste and high levels of pollutants. Plastic materials are among the most predominant of such pollutants. Based on the need for additional research in this area, this study examines pressures put to rivers and explores trends related to riverine plastic pollution, with a focus on Asia. Apart from the bibliometric analysis, and relying on the collected information, examples describing the drivers of riverine plastic …

Increased Cytokine Gene Expression And Cognition Risk Associated With Androgen Deprivation Therapy, Shiv Verma, Prem Prakash Kushwaha, Eswar Shankar, Lee E. Ponsky, Sanjay Gupta

Faculty Scholarship

Background: Androgen deprivation therapy (ADT) is a standard treatment modality for locally advanced, high-risk, and metastatic hormone-sensitive prostate cancer. Long-term ADT treatment likely develops side-effects that include changes in cognition or onset of dementia. However, the molecular understanding of this effect remains elusive. We attempt to establish a link between ADT and changes in cognitive function using patient databases and bioinformatics analyses. Methods: Gene expression profiling was performed using RNA sequencing data from Alzheimer patient cohort and compared with the data from advanced-stage prostate cancer patients receiving neoadjuvant antiandrogen therapy. Differentially expressed genes (DEGs) were analyzed using the Ingenuity knowledge …

Effects Of Standardized Hops (Humulus Lupulus L.) Extract On Joint Health: A Randomized, Placebo-Controlled, Double-Blind, Multiple Dose Study, Ralf Jäger, Brett Bernier, Jason Theodosakis, Gregory Bonfilio, Chad Kerksick, Martin Purpura

Faculty Scholarship

Background: This study’s aim was to evaluate the efficacy and safety of 14-days oral supplementation of a standardized hops extract containing 30% alpha acids, Humulus lupulus L. on individuals with osteoarthritis of the knee.

Methods: Thirty-three subjects (26 female, 7 male, 57.0 ± 6.9 years) participated in this randomized, double-blind, multi-dose study. Perceived pain (WOMAC), 20-meter walking performance and clinical safety markers (metabolic panel) was evaluated after 0 and 14 days of standardized hops extract (Perluxan®, 1 g/day [HOPS1G], n = 11 or 2 g/day [HOPS2G], n = 10 or placebo [PLA], n = 12). Changes in WOMAC …

International Society Of Sports Nutrition Position Stand: Tactical Athlete Nutrition, Drew E. Gonzalez, Matthew J. Mcallister, Hunter S. Waldman, Arny A. Ferrando, Jill Joyce, Nicholas D. Barringer, J. Jay Dawes, Adam J. Kieffer, Travis Harvey, Chad M. Kerksick, Jeffrey R. Stout, Tim N. Ziegenfuss, Annette Zapp, Jamie L. Tartar, Jeffrey L. Heileson, Trisha A. Vandusseldorp, Douglas S. Kalman, Bill I. Campbell, Jose Antonio, Richard B. Kreider

Faculty Scholarship

This position stand aims to provide an evidence-based summary of the energy and nutritional demands of tactical athletes to promote optimal health and performance while keeping in mind the unique challenges faced due to work schedules, job demands, and austere environments. After a critical analysis of the literature, the following nutritional guidelines represent the position of the International Society of Sports Nutrition (ISSN).

Obesity Accelerates Acute Promyelocytic Leukemia In Mice And Reduces Sex Differences In Latency And Penetrance, John W. R. Kincaid, Gretchen Weiss, Anne E. Hill-Baskin, Heidi M. Schmidt, Ovwoioise Omoijuanfo, Cheryl L. Thompson, Rose C. Beck, Nathan A. Berger

Faculty Scholarship

Objective: Obesity has emerged as a prominent risk factor for multiple serious disease states, including a variety of cancers, and is increasingly recognized as a primary contributor to preventable cancer risk. However, few studies of leukemia have been conducted in animal models of obesity. This study sought to characterize the impact of obesity, diet, and sex in a murine model of acute promyelocytic leukemia (APL). Methods: Male and female C57BL/6J.mCG+/PR mice, genetically predisposed to sporadic APL development, and C57BL/6J (wild type) mice were placed on either a high-fat diet (HFD) or a low-fat diet (LFD) for up to 500 days. …

Urate-Lowering Therapy For Patients With Gout On Hemodialysis, Reem Alkilany, Douglas Einstadter, Maria Antonelli

Faculty Scholarship

Objective: Gout is the most common form of inflammatory arthritis and is caused by deposition of monosodium urate crystals resulting from a high burden of uric acid (UA). High UA burden also has been associated with increased morbidity and mortality in the general population and progression to chronic kidney disease. In persons with gout and end-stage renal disease (ESRD), prior studies suggest that UA levels decrease after initiation of hemodialysis (HD). We evaluated UA level and the use of urate-lowering therapies (ULTs) in patients with gout and ESRD on HD. Methods: We performed a retrospective review of patients with gout …

Training The Next Generation Of Translational Scientists: The Case Western Reserve University Translational Fellows Program, Cheryl L. Thompson, Tessianna A. Misko, Mark R. Chance

Faculty Scholarship

Background: An important part of biomedical research is the translation of discoveries into clinical or community applications that impact patient health. For a vast majority of clinical applications and sustainable community interventions, a time-tested way to get innovations to patients is through licensing of the technology and commercial development, often through startups. While biomedical scientists and trainees are schooled in discovery research, the processes of commercialization are foreign or intimidating. Further, many trainees will not aspire to a faculty position, and other avenues of advancement are desirable. Methods: At Case Western Reserve University, we developed and launched a Translational Fellows …

No Hiding From Justice: Universal Jurisdiction In Domestic Courts, Heidi R. Gilchrist

Faculty Scholarship

No abstract provided.

Effects Of High-Volume Versus High-Load Resistance Training On Skeletal Muscle Growth And Molecular Adaptations, Christopher G. Vann, Casey L. Sexton, Shelby C. Osburn, Morgan A. Smith, Cody T. Haun, Melissa N. Rumbley, Petey W. Mumford, Nathan T. Montgomery, Bradley A. Ruple, James Mckendry, Jonathan Mcleod, Adil Bashir, Ronald J. Beyers, Matthew S. Brook, Kenneth Smith, Philip J. Atherton, Darren T. Beck, James R. Mcdonald, Kaeilin C. Young, Stuart M. Phillips, Michael D. Roberts

Faculty Scholarship

We evaluated the effects of higher-load (HL) versus (lower-load) higher-volume (HV) resistance training on skeletal muscle hypertrophy, strength, and muscle-level molecular adaptations. Trained men (n = 15, age: 23 ± 3 years; training experience: 7 ± 3 years) performed unilateral lower-body training for 6 weeks (3× weekly), where single legs were randomly assigned to HV and HL paradigms. Vastus lateralis (VL) biopsies were obtained prior to study initiation (PRE) as well as 3 days (POST) and 10 days following the last training bout (POSTPR). Body composition and strength tests were performed at each testing session, and biochemical assays were …

Similar Mortality Among United States Veterans With Invasive And Noninvasive Pneumonia Due To Group B Streptococcus, Brigid M. Wilson, Sunah Song, Robin L.P. Jump, Federico Perez

Faculty Scholarship

Background: The nosology of noninvasive pneumonia due to group B Streptococcus (GBS) is not well defined. This study compared clinical characteristics and outcomes of patients with invasive pneumonia and noninvasive pneumonia caused by GBS. Methods: We conducted a retrospective cohort study among Veterans Affairs (VA) healthcare users between 2008 and 2017. Using data from electronic health records, we identified patients who had blood or respiratory cultures that grew GBS and had invasive pneumonia or noninvasive pneumonia. We analyzed patient and infection characteristics associated with all-cause mortality, including among the subset of patients with cultures that were monomicrobial for GBS. Results: …

Contributing Factors To Low Energy Availability In Female Athletes: A Narrative Review Of Energy Availability, Training Demands, Nutrition Barriers, Body Image, And Disordered Eating, Andrew R. Jagim, Jennifer Fields, Meghan K. Magee, Chad M. Kerksick, Margaret T. Jones

Faculty Scholarship

Relative Energy Deficiency in sport is experiencing remarkable popularity of late, particularly among female athletes. This condition is underpinned by low energy availability, which is a byproduct of high energy expenditure, inadequate energy intake, or a combination of the two. Several contributing factors exist that may predispose an athlete to low energy availability, and therefore a holistic and comprehensive assessment may be required to identify the root causes. The focus of the current narrative review is to discuss the primary contributing factors as well as known risk factors for low energy availability among female athletes to help practitioners increase awareness …

Directly Observed Weekly Fluoxetine For Major Depressive Disorder Among Hemodialysis Patients: A Single-Arm Feasibility Trial, Kelley M. Kauffman, Jacqueline Dolata, Maria Figueroa, Douglas Gunzler, Anne Huml, Julie Pencak, Martha Sajatovic, Ashwini R. Sehgal

Faculty Scholarship

Rationale & Objective: Major depressive disorder (MDD) is common among hemodialysis patients, but treatment can add to their pill burden and may be limited by nonadherence. We sought to investigate the value of directly observed, once-weekly fluoxetine dosing in MDD. Study Design: Feasibility trial of adult hemodialysis patients with untreated MDD. The diagnosis of MDD was determined using the Mini International Neuropsychiatric Interview. Setting & Participants: 16 patients at 15 hemodialysis facilities in Northeast Ohio. Intervention: Patients were initially prescribed 20 mg of fluoxetine once daily for 2 weeks to assess their tolerance. The patients took this daily fluoxetine unobserved …

Prevalence And Amounts Of Common Ingredients Found In Energy Drinks And Shots, Andrew R. Jagim, Patrick S. Harty, Abdelrahman R. Barakat, Jacob L. Erickson, Victoria Carvalho, Chinguun Khurelbaatar, Clayton L. Camic, Chad M. Kerksick

Faculty Scholarship

Background: Energy drinks are one of the most popular packaged beverage products consumed within the United States (US). Energy drinks are considered a functional beverage, a category that also includes sports drinks and nutraceutical beverages. Purpose: The focus of the current study was to examine the nutrition fact panels of the top selling commercially available energy drink and energy shot products within the US to characterize common ingredient profiles to help establish a standard definition and ingredient profile of energy drinks and energy shots for consumers, health care practitioners, and researchers. Methods: The top 75 commercially available energy drinks and …

Optimizing Biomedical Discoveries As An Engine Of Culture Change In An Academic Medical Center, Anne K. Dechant, Stephen Fening, Michael Haag, William Harte, Mark R. Chance

Faculty Scholarship

Academic discovery in biomedicine is a growing enterprise with tens of billions of dollars in research funding available to universities and hospitals. Protecting and optimizing the resultant intellectual property is required in order for the discoveries to have an impact on society. To achieve that, institutions must create a multidisciplinary, collaborative system of review and support, and utilize connections to industry partners. In this study, we outline the efforts of Case Western Reserve University, coordinated through its Clinical and Translational Science Collaborative (CTSC), to promote entrepreneurial culture, and achieve goals of product development and startup formation for biomedical and population …

Divest, Invest, & Mutual Aid, Cynthia Godsoe, Caitlyn Garcia

Faculty Scholarship

No abstract provided.

The Legal Role In Building Sustainable Public Health (Symposium Transcript), Joanna K. Sax

Faculty Scholarship

The article presents a discussion of food as a public health issue, beginning with why science matters and utilizing science to solve food as a public health issue, especially as it relates to sustainability and climate change. Consumer misperceptions of the risk created by new scientific technologies (e.g., GMOs), or even older scientific technologies, may thwart use of such technologies to solve sustainability problems. The talk addresses why consumers might inappropriately assign risk to certain scientific applications and ways that we might want to think about resolving that issue or closing the divide between consumer misperception of risk and evidence-based …

Paths To Downstream Innovation, Janet Freilich

Faculty Scholarship

No abstract provided.

Telemedicine Scams, Katrice B. Copeland

Faculty Scholarship

Telemedicine emerged as a lifeline during the COVID-10 pandemic. Although the technology existed long before the pandemic, its use was limited due to strict government regulations that limited reimbursement for telemedicine visits. In response to the pandemic, the Government waiver many of its restrictions for the duration of the Public Health Emergency. These changes fueled the growth of telemedicine.

The problem, however, is that telemedicine makes it easier to conduct fraud on a larger scale because without in-person visits, medical providers can reach many more beneficiaries in a short period of time. Thus, the size and scale of typical health …

Economic Influence Activities And The Strategic Location Of Investment, John M. De Figueiredo, Davin Raiha

Faculty Scholarship

This article examines the economic influence activities (EIAs) of firms. We argue that firms invest in jobs and establishments in districts of congressional committee members that have oversight over their businesses and industries. This investment increases as legislators’ power rises in Congress. Our theory makes three predictions. First, EIAs by firms will be higher in congressional districts where the legislators have substantial political influence over the firm, relative to districts where legislators have little influence over the firm. Second, EIAs will increase with the legislators’ power on the focal committee. Third, when a legislator exits the committee, EIAs will diminish, …

Moral Economies Of Family Reunification In The Trump Era: Translating Natural Affiliation, Autonomy, And Stability Arguments Into Constitutional Rights, Kerry Abrams, Daniel Pham

Faculty Scholarship

No abstract provided.

Generals Of The Resistance: Multistate Actions And Nationwide Injunctions, Elysa M. Dishman

Faculty Scholarship

State attorneys general (AGs) have become leaders of the political resistance against recent presidential administrations. They are suing the federal government with increasing frequency, seeking nationwide injunctions that thwart presidential priorities and shape national policies.

Nationwide injunctions have sparked considerable debate among jurists, scholars, and policymakers. However, the largely court-centric debate has overwhelmingly overlooked the role that state litigants and litigators play in shaping criticisms of the nationwide injunction. States and AGs have unique
attributes, advantages, and incentives that allow them to frequently seek and successfully secure nationwide injunctions. And these advantages are enhanced when states litigate together. Because states …

Actively Achieving Greater Racial Equity In The Law School Classroom, Catherine Bramble

Faculty Scholarship

2020 and 2021 continue to illustrate the pervasiveness of implicit and explicit racism in our society. Less well-acknowledged and recognized is the extent to which Socratic pedagogy also reflects those pervasive racist realities while simultaneously resulting in inferior learning based on a teaching method invented 150+ years ago. Despite this racist and outdated reality, the legal academy has been reluctant to alter the traditional method of teaching. Tangible, empirical evidence obtained from data-driven cognitive learning science research demonstrates that active learning not only improves learning outcomes for all students, but also mitigates the structural effects of racism in the classroom …