Digital Commons Network^™

The Virtual Wunderkammer: Integrating Neuroinclusive Design And Ai-Augmented Technologies For Immersive Museum Experiences, Piper Hutson, James Hutson

Faculty Scholarship

The Virtual Wunderkammer represents an innovative paradigm in museum exhibition design, integrating neuroinclusive principles with artificial intelligence (AI)-augmented technologies to foster immersive and cognitively accessible visitor experiences. Historically, the Wunderkammer, or "cabinet of curiosities," served as a precursor to modern museums, offering eclectic collections that stimulated intellectual curiosity and sensory engagement. The contemporary reimagining of this concept utilizes emerging technologies such as augmented reality (AR), virtual reality (VR), haptic feedback, and olfactory-enhanced digital environments to create personalized, adaptive museum experiences. This study explores the critical intersection of neuroaesthetics, cognitive science, and AI-driven interactivity in digital exhibitions, emphasizing their potential to …

Regionalism And The Federal Reserve Banks, Kathryn Judge, Lev Menand

Faculty Scholarship

Regionalism is central to our country’s central banking system. Rather than rely on a single organization to set monetary policy and oversee banks, Congress created a multiplicity of bodies including twelve Federal Reserve Banks (FRBs), each designed to operate in a different part of the country. These FRBs are an early and undertheorized example of how the federal government uses regional bodies to formulate and administer federal policy. When they were first authorized in 1913, their regional character assuaged concerns about centralizing power over the economy. Today, the FRBs continue to play a number of important roles, helping to shape …

Shadow Banking And Securities Law, Gabriel Rauterberg, Jeffery Y. Zhang

Faculty Scholarship

Shadow banking may be the single greatest challenge facing financial regulation. Financial institutions that function like banks, but fall outside the scope of banking regulation — aptly termed “shadow banks” — were at the heart of the Global Financial Crisis and most episodes of serious financial stress since then. Scholars have largely focused on one response to this problem: extending traditional banking regulation to shadow banks. Yet more than fifteen years after the crisis, major regulatory efforts along this route have stalled.

In this Article, we explore the uneasy case for greater regulation of shadow banking through a different route …

Mainstreaming Parafamily, Elizabeth F. Emens

Faculty Scholarship

In Parafamily, Chen and Mulligan have managed to cover vast terrain, to catalogue important developments in law, to canvass insights from generations of thinkers, and to propose an ambitious yet pragmatic approach to the laws that govern human relationships, directly and indirectly. They do all this in a relatively short article composed of unusually readable prose. Quite a feat.

The focus of the piece is Chen and Mulligan’s contribution to the field of legal scholarship dedicated to relationships that go beyond the traditional nuclear family. As their title reveals, the authors contribute a new term and concept to this …

Public Funds, Public Functions, Private Actors: The Cognitive Dissonance Of Us Health Law, William M. Sage

Faculty Scholarship

This chapter begins with the evolution of American medicine from a “sovereign” self-regulating profession focused on direct patient service to a large industry that serves the social sector but that, because of its professional heritage, receives extensive public subsidies without equivalent public accountability. Next, the chapter identifies regulatory dynamics in American health care governance that structurally discourage movement from the prevailing, if dissonant, private law framework to one explicitly grounded in public law. The chapter concludes by highlighting the challenges and opportunities inherent in a private law approach to what is intuitively a public law domain.

Celebrating 70 Years Of Health Law At Bu, Christopher Robertson, Elizabeth Mccuskey, Aziza Ahmed, Dionne Lomax, Kathryn Zeiler, Dianne Mccarthy, Laura Stephens, Michael Ulrich, Lawrence Vernaglia, Danielle Pelfrey Duryea, Nicole Huberfeld, Kevin Outterson

Faculty Scholarship

This essay celebrates the BU Health Law Program upon its 70th anniversary, offering reflections on the founders of the program, Fran Miller, George Annas, and Wendy Mariner (“FGW,” endearingly), and their contributions to the field.

Current faculty offer reflections, including: Several speak to scholarly research, including Elizabeth McCuskey on health care finance, Aziza Ahmed on human rights, Dionne Lomax on antitrust, Christopher Robertson on trust, and Kathy Zeiler on the marketplace. Other contributors speak to the student experience, with Dianne McCarthy on mentorship, Laura Stephens on demanding excellence, Michael Ulrich on teaching, and Larry Vernaglia on merging law and public …

Legislating For The Future, Jonathan S. Gould, Rory Van Loo

Faculty Scholarship

Public policy must address threats that will manifest in the future. Legislation enacted today affects the severity of tomorrow’s harms arising from biotechnology, climate change, and artificial intelligence. This Essay focuses on Congress’s capacity to confront future threats. It uses a detailed case study of financial crises to show the limits and possibilities of legislation to prevent future catastrophes. By paying insufficient attention to Congress, the existing literature does not recognize the full nature and extent of the institutional challenges in regulating systemic risk. Fully recognizing those challenges reveals important design insights for future-risk legislation.

We first examine Congress as …

Psychosocial Burden And Suicidality In Epilepsy: A Public Health Concern, Martha Sajatovic

Faculty Scholarship

The increased risk for psychosocial burden and suicidality in people with epilepsy compared to the general population is a well-established global public health concern. Suicidality risk is also increased in patients with functional seizures. The timely identification of patients at highest risk for psychosocial burden and self-harm is vital. This can pose a significant challenge for multidisciplinary clinicians caring for people with epilepsy. Early identification of social stressors and comorbid psychiatric contributors via screening are required to assist with the development of predictive models for self-harm in epilepsy; and subsequent options for treatment and the provision of adjunct supports in …

Examination Of Protective Factors That Promote Prosocial Skill Development Among Children Exposed To Intimate Partner Violence, Megan R. Holmes, Anna E. Bender, Kristen A. Berg, Kylie E. Evans, Amy Korsch-Williams, Adam T. Perzynski

Faculty Scholarship

This retrospective cohort study examined prosocial skills development in child welfare-involved children, how intimate partner violence (IPV) exposure explained heterogeneity in children's trajectories of prosocial skill development, and the degree to which protective factors across children's ecologies promoted prosocial skill development. Data were from 1,678 children from the National Survey of Child and Adolescent Well-being I, collected between 1999 and 2007. Cohort-sequential growth mixture models were estimated to identify patterns of prosocial skill development between the ages of 3 to 10 years. Four diverse pathways were identified, including two groups that started high (high subtle-decreasing; high decreasing-to-increasing) and two groups …

Development Of A Self-Management Tool For Individuals With Seizure Clusters: Trial Design And Methodological Report, Molly Mcvoy, Eytan Hirsch, Luisa Londono, Kari Colón-Zimmermann, Jin Seok Cho, Evelyn K. Shih, Martha Sajatovic

Faculty Scholarship

Background: Despite advances in anti-seizure medications (ASMs) for people with epilepsy (PWE), adverse outcomes, negative health events (NHEs), and breakthrough seizures remain common. Rescue medication (RM) can better manage repetitive seizures, but barriers to RM use persist. Self-management for PWE and a history of NHEs (SMART) is an evidence-based epilepsy self-management program aimed at reducing barriers and maximizing facilitators to self-care in high-risk PWE. Methods: This 2-phase, ongoing clinical trial adapts SMART to integrate RM support for PWE with repetitive seizures. Phase 1, now completed, used input from an advisory board (AB) of PWE, caregivers, and clinicians to adapt the …

Prevalence Of Social Determinants Of Health Risk Factors Among And Their Impact On Viral Suppression, Consistent Visits, And No-Show Rates Among Persons With Hiv Who Identify As Hispanic, Mary Cowden, Ana Clavijo, Pragnya Iyengar, Ann Avery

Faculty Scholarship

The current study examines the association between language preference, social determinants of health (SDOH) risk factors, viral load, and HIV care outcomes among individuals of Hispanic ethnicity in the United States. More than half (54%) of all participants reported having two or more unmet needs. Hispanic individuals were more likely to be at risk in 2 or more domains than their non-Hispanic counterparts. Food insecurity was the most common risk factor reported and when present, 51% of patients also reported financial resource strain. Surprisingly, when language preference was analyzed, English-preferring Hispanic patients were at higher risk of financial resource strain, …

Postnatal Progressive Craniosynostosis: An Unusual Case Presentation Leading To Cascade Diagnosis For Multiple Generations, Jessica T. Ogawa, Maura Guyler, Krystal L. Tomei, Howard D. Wang

Faculty Scholarship

NM_000141.5: FGFR2 c.1032G>A is a pathogenic variant that causes Crouzon syndrome through activation of a new donor splice site. This clinical report highlights the intrafamilial variability that can exist with this specific variant. The proband is a 4-year-old boy who initially presented with concern for seizures. Computed tomography and magnetic resonance imaging revealed pancraniosynostosis and Chiari 1 malformation. Papilledema on fundoscopic exam and copper beaten appearance of the skull on imaging both suggested the presence of elevated intracranial pressure. Genetic testing identified c.1032G>A (p.Ala344=) in FGFR2. Familial testing and genetic evaluation confirmed the same pathogenic variant in the …

Examining The Relationship Between Frailty, Operative Management, And 90-Day Mortality Across Emergency General Surgery Conditions, Caleb W. Curry, Marisa R. Imbroane, Wyatt P. Bensken, Adam T. Perzynski, Christopher W. Towe, Vanessa P. Ho

Faculty Scholarship

No abstract provided.

Scalability Of A Graph Neural Network In Accurate Prediction Of Frictional Contact Networks In Suspensions, Armin Aminimajd, Joao Maia, Abhinendra Singh

Faculty Scholarship

Dense suspensions often exhibit shear thickening, characterized by a dramatic increase in viscosity under large external forcing. This behavior has recently been linked to the formation of a system-spanning frictional contact network (FCN), which contributes to increased resistance during deformation. However, identifying these frictional contacts poses experimental challenges and is computationally expensive. This study introduces a graph neural network (GNN) model designed to accurately predict FCNs by two dimensional simulations of dense shear thickening suspensions. The results demonstrate the robustness and scalability of the GNN model across various stress levels (s), packing fractions (f), system sizes, particle size ratios (D), …

Aging Is Associated With Decreased Lactobacillus And Increased Cervicovaginal Inflammation In Canadian Women, Ha T. Dang, Laura Noel-Romas, Samantha Knodel, Kenzie Birse, Hossaena Ayele, Alicia R. Berard, Adam D. Burgener, Christina Farr Zuend

Faculty Scholarship

Problem: Aging is characterized by a general dysregulation of systemic immune responses that increases susceptibility to infections and malignancies. Immune cells in the female genital tract (FGT) are regulated by sex hormones, but little is known about the impact of aging and menopause on immunology in the FGT. Method of Study: This study conducted an age-focused sub-analysis of cervicovaginal samples collected from 47 women enrolled in the Vaginal Mucosal Systems study in Winnipeg, Canada. Paired cervicovaginal lavage and cervical cytobrush were collected and analyzed by Luminex cytokine array, mass spectrometry based metaproteomics, metabolomics, and high dimensional flow cytometry. Results: The …

Towards More Sustainable Oceans: A Review Of The Pressing Challenges Posed By Marine Plastic Litter, Peter Yang

Faculty Scholarship

Marine littering is a global challenge and a significant threat to a sustainable planet, requiring comprehensive and effective mechanisms to address it in a comprehensive manner. This study reports on a bibliometric analysis that has identified the extent to which the topic has been explored in the international literature, by focusing on geographical scope, the emphasis on (micro)plastic litter and on policy measures. Additionally, as a complement to the assessment of the recent literature on marine plastic litter, this study reviews some case studies, identifying some trends on how to cope with this problem. The findings underscore the imperative for …

Novel Biomarkers Of Fetal And Neonatal Environmental Exposure, Effect And Susceptibility, Cynthia F. Bearer

Faculty Scholarship

Abstract: Rapid advancements in science and technology have allowed medical providers to treat wider ranges of diseases with safer and more effective therapies than ever before. One of the areas of health that has been consistently understudied, however, is one that affects us all: environmental health or the effects that the chemicals we are exposed to every day have on our acute and chronic health. This effect can be exacerbated during and shortly after pregnancy, as an individual exposure is often shared by both the mother and the fetus/neonate. The diagnosis and monitoring of chemical exposure can be quite challenging, …

Thrombocytopenia In Sepsis, Alireza Setarehaseman, Robert W. Maitta

Faculty Scholarship

Platelets, traditionally known for their role in hemostasis, have emerged as key players in immune response and inflammation. Sepsis, a life-threatening condition characterized by systemic inflammation, often presents with thrombocytopenia, which at times, can be significant. Platelets contribute to the inflammatory response by interacting with leukocytes, endothelial cells, and the innate immune system. However, excessive platelet activation and consumption can lead to thrombocytopenia and exacerbate the severity of sepsis. Understanding the multifaceted roles of platelets in sepsis is crucial for developing effective therapeutic strategies. Targeting platelet-mediated inflammatory responses and promoting platelet production may offer potential avenues for improving outcomes in …

The Evolution And Future Of Microservices Architecture With Ai-Driven Enhancements, Jill Willard, James Hutson

Faculty Scholarship

Microservices architecture has revolutionized software development by enabling the decomposition of monolithic applications into smaller, more manageable services. While this shift has reduced risks and enhanced system resiliency, the increasing complexity of managing numerous microservices presents new challenges. As Artificial Intelligence (AI) continues to evolve, there is a growing need to explore how autonomous AI agents can optimize microservices architectures, particularly in terms of communication and workflow orchestration. The purpose of this study is to investigate how AI agents can autonomously interact and manage microservices, reducing human intervention and enhancing system efficiency. The key research question guiding this investigation relates …

Elevation In White Blood Cell Count After Corticosteroid Use In Noninfected Hospitalized Patients, Erin Sullivan, Michael B. Rothberg

Faculty Scholarship

Background: It is widely accepted that corticosteroids cause leukocytosis. Clinicians must decide whether a rise in white blood cell (WBC) count is due to steroids versus other processes like developing infection. Objective: The objective of this study is to measure the increase in white blood cell count after corticosteroid administration in hospitalized patients without malignancy, infection, or immune dysfunction. Methods: This is a retrospective cohort study from 2017 to 2018 in a single large healthcare system. We analyzed the trajectory of WBC count stratified by steroid dose. The study included nonsurgical patients admitted with at least two complete blood count …

Exploring The Connection Between Rna Splicing And Intellectual Disability, Anthony Caputo, Ashleigh E. Schaffer

Faculty Scholarship

Intellectual disability (ID) is a broad diagnostic category that encompasses individuals with impaired cognitive ability. While these disorders have heterogeneous causes, recent developments in next-generation sequencing (NGS) are revealing the prevalence of genetic etiologies. In particular, germline mutations in genes that affect RNA splicing are increasingly common causes of ID disorders. Research to elucidate the functional relationship between splicing and neurodevelopment is critical since molecular therapeutics require a nuanced understanding of the pathological mechanism. In this review, we first summarize the trends that have led to the discovery of the RNA splicing–ID relationship, then discuss recent progress and future directions …

Association Between Combined Oral Contraceptive Prescription And Cervical Artery Dissection: A Retrospective Cohort Study, Robert J. Trager, Catherine P. Haering

Faculty Scholarship

Background: To date, research has identified positive associations between combined oral contraceptives (COCs) and adverse vascular events, however, evidence regarding the possible association with cervical artery dissection (CeAD) remains limited. We tested the hypothesis of a positive association between COCs and CeAD within one year following COC initiation compared to matched controls initiating intrauterine devices (IUDs), as measured by risk ratio (RR). Methods: We queried de-identified United States health records data (TriNetX, Inc.) from 2014 to 2024 for females aged 15–50 years without previous cerebrovascular disease or CeAD, creating mutually exclusive cohorts initiating either COCs or IUDs. We used propensity …

International Society Of Sports Nutrition Position Stand: Nutrition And Weight Cut Strategies For Mixed Martial Arts And Other Combat Sports, Anthony A. Ricci, Cassandra Evans, Charles Stull, Corey A. Peacock, Duncan N. French, Jeffrey R. Stout, David H. Fukuda, Paul La Bounty, Douglas Kalman, Andrew J. Galpin, Jaime Tartar, Sarah Johnson, Richard B. Kreider, Chad Kerksick, Bill I. Campbell, Aaron Jeffery, Chris Algieri, Jose Antonio

Faculty Scholarship

Following an extensive literature review, the International Society of Sports Nutrition (ISSN) has developed an official position on nutritional and weight cut strategies for combat sports. The type of combat sport, length of the fight camp, and time between weigh-in and competition are factors influencing nutritional and weight cut strategies. The following 16points constitute the Position Statement of the Society; the Research Committee has approved them. 1. Combat sports have differing weight categories, official weigh-in times, and competition frequencies, influencing the nutritional and weight cut strategies for training and competition. 2. As the duration of a combat match increases, >4 …

Prediction Of Obstructive Coronary Artery Disease Using Coronary Calcification And Epicardial Adipose Tissue Assessments From Ct Calcium Scoring Scans, Juhwan Lee, Tao Hu, Ammar Hoori, Hao Wu, Justin N. Kim, Robert Gilkeson, Sanjay Rajagopalan, David L. Wilson

Faculty Scholarship

Background: Low-cost/no-cost non-contrast CT calcium scoring (CTCS) exams can provide direct evidence of coronary atherosclerosis. In this study, using features from CTCS images, we developed a novel machine learning model to predict obstructive coronary artery disease (CAD), as defined by the coronary artery disease-reporting and data system (CAD-RADS). Methods: This study analyzed 1324 patients from the SCOT-HEART trial who underwent both CTCS and CT angiography. Obstructive CAD was defined as CAD-RADS 4A-5, while CAD-RADS 0–3 were considered non-obstructive CAD. We analyzed clinical, Agatston-score-derived, and epicardial fat-omics features to predict obstructive CAD. The most predictive features were selected using elastic net …

Should Positive Airway Pressure Be Continued Uninterrupted After Endoscopic Skull Base Surgery? A Review Of Current Literature, Jayanth Rajan, John Richter, Daniel Karasik, Claudia I. Cabrera, John Gerka Stuyt, Kenneth Rodriguez, Brian D'Anza, Thomaz Fleury Curado, Sanjeet V. Rangarajan

Faculty Scholarship

Obstructive sleep apnea (OSA) poses unique challenges to the perioperative management of endoscopic skull base surgery (ESBS). Currently, no consensus or guidelines exist on the reintroduction of positive airway pressure (PAP) in these patients. To better clarify the safety of PAP reintroduction after ESBS, the databases Pubmed and Embase were searched in May 2024 for studies on PAP reintroduction after ESBS. Two articles, comprising 15 patients, met the inclusion criteria. All patients resumed PAP the first night after surgery. All patients underwent ESBS for transsphenoidal pituitary resection. Only one patient experienced cerebrospinal fluid leak, and no other complications were reported. …

Screening And Treatment Of Iron Deficiency Among Heart Failure Patients With Impaired Ejection Fraction: The Impact Of A Pharmacist-Led Protocol, Firas Al Badarin, Feras Bader, Bassam Atallah

Faculty Scholarship

Background: Despite guideline-recommended routine screening and iron deficiency (ID) treatment among heart failure (HF) patients, these practices are often underutilized. Currently, limited data are available on the outcomes of pharmacists' programs to enhance ID screening and management. Accordingly, we sought to describe the frequency and yield of screening for ID and intravenous (IV) iron replacement rates among our cohort of HF patients and examined the impact of implementing a pharmacist-led protocol (PLP) aimed at enhancing these rates. Methods: We conducted a retrospective study involving HF patients with left ventricular ejection fraction (LVEF) <45% at a quaternary care hospital in the Middle East/Gulf region. The PLP was introduced in August 2022. Data on demographics, comorbidities, echocardiographic parameters, laboratory findings (including ID screening and its findings), and rates of treatment with IV iron replacement were analyzed and compared between the pre-implementation group (n = 432, October 2015–February 2020) and the post-implementation group (n = 154, August 2022–January 2023). Results: Before the PLP, 63.2% (n = 273) of eligible patients underwent ID screening, with 80.6% (n = 220) found to have ID. Following the implementation of the PLP, screening rates significantly increased to 86.4% (n = 133) (p = 0.03), with 53.4% (n = 71) diagnosed with ID. The rate of IV iron replacement in ID patients improved from 30.4% (n = 67) in the pre-PLP group to 73% (n = 52) in the post-PLP group (p < 0.001). Multivariable logistic regression identified baseline glomerular filtration rate (GFR) and hemoglobin levels as significant predictors of IV iron replacement in the pre-PLP cohort. Conclusions: Implementing a pharmacist-led protocol was significantly associated with enhancing the screening and treatment of ID in patients with HF and LVEF <45%. This study demonstrates the crucial role of pharmacists in optimizing guideline-directed therapies, which can be replicated in various healthcare settings.

What The Hell Is The Major Questions Doctrine?, Jack M. Beermann

Faculty Scholarship

Anita S. Krishnakumar, What the New Major Questions Doctrine Is Not, 92 Geo. Wash. L. Rev. 1117 (2024).

When the sun sets in New York City, it rises in Tokyo. Okay, maybe not exactly, but you get the idea: setting somewhere, rising somewhere else. Now substitute Chevron for N.Y.C. and the Major Questions Doctrine for Tokyo. For the past forty years, administrative law scholars have been arguing over Chevron, and now that the sun has set on that doctrine, it’s time to turn our attention to the new rising sun, the Major Questions Doctrine (“MQD”). The sudden emergence …

Is Cardiomyopathy Intrinsic To Marfan Syndrome?, Carolyn M. Wilhelm, James Strainic, Timothy J. Mead

Faculty Scholarship

No abstract provided.

The Other Secret Deals: Uncovering The Power Of Non-Binding International Agreements, Guillermo J. Garcia Sanchez

Faculty Scholarship

In recent decades, the use of traditional international treaties has declined as states increasingly rely on deformalized agreements - non binding arrangements - such as interinstitutional agreements and memoranda of understanding. These agreements allow governments to bypass the complexities of formal treaty-making while addressing shared challenges. This Article, based on four years of research and previously undisclosed agreements, examines a twenty-year database of non-binding agreements between the United States and Mexico. Through this case study, the Article demonstrates how deformalized agreements drive much of the cross-border collaboration, offering a flexible mechanism for government agencies to shape state behavior, coordinate policies, …

We Need To Talk: Modernizing Attorney-Client Jail Communications, Cynthia Alkon

Faculty Scholarship

Attorney-client jail phone calls, video calls, and emails are all routinely recorded and monitored by jails, with numerous examples of jails and private telecommunications providers giving those recordings and emails to law enforcement and prosecutors. This widespread failure to protect the confidentiality of attorney-client communications prevents lawyers from being able to enjoy easy, quick, and regular communications with their clients. In practice, and despite the ever-expanding communication methods in the outside world, those held in jails in this country while their criminal cases are pending are effectively stuck in the nineteenth century when the only way to communicate was in …