Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Faculty Scholarship

Discipline
Institution
Keyword
Publication Year
File Type

Articles 931 - 960 of 6491

Full-Text Articles in Entire DC Network

Bridge Building In Higher Education: Multi-Modal Mentoring Programs To Support Retention & Career Preparedness, James Hutson, Roger Nasser, Michael Marzano, Ryan Curtis, Elizabeth Macdonald, Sue Edele, Barbara Hosti-Marti Sep 2022

Bridge Building In Higher Education: Multi-Modal Mentoring Programs To Support Retention & Career Preparedness, James Hutson, Roger Nasser, Michael Marzano, Ryan Curtis, Elizabeth Macdonald, Sue Edele, Barbara Hosti-Marti

Faculty Scholarship

Despite the limitations on time for career preparedness and shrinking professional development budgets, mentoring remains as important as ever due to the interconnectedness in a global society and the changing demographics of postsecondary education students. The traditional-age population in college that lives on campus and does not work has been declining for over three decades. The majorities of current students that are now non-traditional, and work at least part-time are first-generation, and are pursuing degrees via distance or online learning. The importance of providing a diverse mentoring strategy for this new population is borne out in research in order to …


Combinations Of Chronic Conditions, Functional Limitations And Geriatric Syndromes Associated With Periodontal Disease, Hussam M. Alqahtani, Siran M. Koroukian, Kurt C. Stange, Nabil F. Bissada, Nicholas K. Schiltz Aug 2022

Combinations Of Chronic Conditions, Functional Limitations And Geriatric Syndromes Associated With Periodontal Disease, Hussam M. Alqahtani, Siran M. Koroukian, Kurt C. Stange, Nabil F. Bissada, Nicholas K. Schiltz

Faculty Scholarship

Objective To identify complex multimorbid conditions, including chronic conditions, functional limitations and geriatric syndromes, associated with the presence and severity of periodontal disease (PD), after accounting for a series of demographic and behavioural characteristics. Design This cross-sectional study used secondary data from a nationally representative sample, classification and regression tree analysis and random forest identified combinations of specific conditions constituting complex multimorbidity associated with the presence and severity of PD. Setting US National Health and Nutritional Examination Survey (2013-2014). Participants Individuals 60 years of age or older who completed a periodontal examination. Results Among 937 participants aged 60 and over, …


Augmented Creativity: Leveraging Natural Language Processing For Creative Writing, Daniel Plate, James Hutson Aug 2022

Augmented Creativity: Leveraging Natural Language Processing For Creative Writing, Daniel Plate, James Hutson

Faculty Scholarship

Recent advances have moved natural language processing (NLP) capabilities with artificial intelligence beyond mere grammar and spell-checking functionality. One such new use that has arisen is the ability to suggest new content to writers to inspire new ideas by using “machine-in-the-loop” strategies in creative writing. In order to explore the possibilities of such a strategy, this study provides a model to be adopted in creative writing courses in higher education. An NLP application was created using Python and spaCy and deployed via Streamlit. The AI allowed students to see if their grammar aligned with those principles and techniques taught in …


Launching Into Life After College, Leonard J. Shedletsky, Jeanette Andonian Dr., David Bantz Dr., Dennis Gibson Mfa Aug 2022

Launching Into Life After College, Leonard J. Shedletsky, Jeanette Andonian Dr., David Bantz Dr., Dennis Gibson Mfa

Faculty Scholarship

ABSTRACT This chapter reports on a course that is designed to facilitate the students’ transition out of college and into life after graduation. It describes how the course foregrounds the problems students face, both the technical aspects of the transition and the emotional experience, unthought out ideas about what the students want, their goals, and how they might go about achieving their goals. The authors report on the course culture, assignments, observations from teaching the course, student feedback from focus groups, surveys, behavior, as well as summaries of data on the student’s experience. The need for this course is supported …


Resolving Ultrafast Photoinitiated Dynamics Of The Hachimoji 5-Aza-7-Deazaguanine Nucleobase: Impact Of Synthetically Expanding The Genetic Alphabet, Sarah E. Krul, Sean J. Hoehn, Carlos E. Crespo-Hernández Aug 2022

Resolving Ultrafast Photoinitiated Dynamics Of The Hachimoji 5-Aza-7-Deazaguanine Nucleobase: Impact Of Synthetically Expanding The Genetic Alphabet, Sarah E. Krul, Sean J. Hoehn, Carlos E. Crespo-Hernández

Faculty Scholarship

The guanine derivative, 5-aza-7-deazaguanine (5N7CG) has recently been proposed as one of four unnatural bases, termed Hachimoji (8-letter) to expand the genetic code. We apply steady-state and time-resolved spectroscopy to investigate its electronic relaxation mechanism and probe the effect of atom substitution on the relaxation mechanism in polar protic and polar aprotic solvents. Mapping of the excited state potential energy surfaces is performed, from which the critical points are optimized by using the state-of-art extended multi-state complete active space second-order perturbation theory. It is demonstrated that excitation to the lowest energy 1ππ* state of 5N7CG results …


A Randomized Controlled Trial Of Customized Adherence Enhancement (Cae-E): Study Protocol For A Hybrid Effectiveness-Implementation Project, Jennifer B. Levin, Farren Briggs, Carol Blixen, Douglas Einstadter, Jeffrey M. Albert, Celeste Weise, Edna Fuentes-Casiano, Kristin A. Cassidy, Martha Sajatovic Aug 2022

A Randomized Controlled Trial Of Customized Adherence Enhancement (Cae-E): Study Protocol For A Hybrid Effectiveness-Implementation Project, Jennifer B. Levin, Farren Briggs, Carol Blixen, Douglas Einstadter, Jeffrey M. Albert, Celeste Weise, Edna Fuentes-Casiano, Kristin A. Cassidy, Martha Sajatovic

Faculty Scholarship

Background: Mood-stabilizing medications are a cornerstone of treatment for people with bipolar disorder, though approximately half of these individuals are poorly adherent with their medication, leading to negative and even severe health consequences. While a variety of approaches can lead to some improvement in medication adherence, there is no single approach that has superior adherence enhancement and limited data on how these approaches can be implemented in clinical settings. Existing data have shown an increasing need for virtual delivery of care and interactive telemedicine interventions may be effective in improving adherence to long-term medication. Methods: Customized adherence enhancement (CAE) is …


Group B Streptococcus In The Urine In Nonpregnant Adults: Disease Or Distraction?, Nicole Mongilardi, Brigid M. Wilson, Sunah Song, Robin L.P. Jump, Federico Perez Aug 2022

Group B Streptococcus In The Urine In Nonpregnant Adults: Disease Or Distraction?, Nicole Mongilardi, Brigid M. Wilson, Sunah Song, Robin L.P. Jump, Federico Perez

Faculty Scholarship

In this large, retrospective cohort study, we used administrative data to evaluate nonpregnant adults with group B Streptococcus (GBS) bacteriuria. We found greater all-cause mortality in those with urinary tract infections compared to asymptomatic bacteriuria. Differences in patients' baseline characteristics and the 1-year mortality rate raise the possibility that provider practices contribute to differences observed.


Deregulation And The Lawyers' Cartel, Nuno Garoupa, Milan Markovic Aug 2022

Deregulation And The Lawyers' Cartel, Nuno Garoupa, Milan Markovic

Faculty Scholarship

At one time, the legal profession largely regulated itself. However, based on the economic notion that increased competition would benefit consumers, jurisdictions have deregulated their legal markets by easing rules relating to attorney advertising, fees, and, most recently, nonlawyer ownership of law firms. Yet, despite reformers’ high expectations, legal markets today resemble those of previous decades, and most legal services continue to be delivered by traditional law firms. How to account for this seeming inertia?

We argue that the competition paradigm is theoretically flawed because it fails to fully account for market failures relating to asymmetric information, imperfect information, and …


Putting Labor’S Capital To Work For Labor: Restoring A Worker-Centric Vision Of Fiduciary Duty, David H. Webber Aug 2022

Putting Labor’S Capital To Work For Labor: Restoring A Worker-Centric Vision Of Fiduciary Duty, David H. Webber

Faculty Scholarship

This report has two goals: first, to illustrate how the legal concept of fiduciary duty, designed to protect worker retirement funds, has been captured and distorted in ways that harm workers. Second, to propose means of restoring fiduciary duty to its proper purpose. The state-level fiduciary duties addressed in this report govern the investment of up to $10 trillion in assets and directly shape the retirements of 26 million working-class Americans. They are also just about the only source of worker voice in capital markets and corporate boardrooms. That is why a range of powerful business lobbies have distorted the …


Can Moral Framing Drive Insurance Enrollment In The Us?, Wendy Netter Epstein, Christopher Robertson, David Yokum, Hansoo Ko, Kevin Wilson, Monica Ramos, Katherine Kettering, Margaret Houtz Aug 2022

Can Moral Framing Drive Insurance Enrollment In The Us?, Wendy Netter Epstein, Christopher Robertson, David Yokum, Hansoo Ko, Kevin Wilson, Monica Ramos, Katherine Kettering, Margaret Houtz

Faculty Scholarship

To encourage health insurance uptake, marketers and policymakers have focused on consumers' economic self-interest, attempting to show that insurance is a good deal or to sweeten the deal, with subsidies or penalties. Still, some consumers see insurance as a bad deal, either because they rationally exploit private risk information (“adverse selection”), or irrationally misperceive the value due to cognitive biases (e.g., optimism). As a result, about 30 million Americans remain uninsured, including many who could afford it. At the same time, polling suggests that Americans view health insurance through a moral lens, seeking to protect those with pre-existing conditions especially. …


“If It Learns Easy, It Taught Hard” Applying Lessons From Practice To The Lawyering Skills Classroom, Laura E. D'Amato Aug 2022

“If It Learns Easy, It Taught Hard” Applying Lessons From Practice To The Lawyering Skills Classroom, Laura E. D'Amato

Faculty Scholarship

The end of the academic year is a natural time for reflection. As I complete my fifth year teaching Lawyering Skills at Boston University School of Law, I am taking time to reflect on my experience. I came to teaching mid-career, after practicing in the litigation group at a Boston firm for fifteen years. I enjoyed mentoring and training junior associates, so teaching was a logical next step. As I reflect on my work as a Lawyering Skills Instructor, I realize that many of the lessons I learned in practice also apply to teaching. The most ubiquitous of these lessons …


Riverine Plastic Pollution In Asia: Results From A Bibliometric Assessment, Peter Yang Jul 2022

Riverine Plastic Pollution In Asia: Results From A Bibliometric Assessment, Peter Yang

Faculty Scholarship

Rivers are important ecosystems, vital to the livelihoods of hundreds of millions of humans and other species. Despite their environmental, social, and economic importance, current use of rivers is unsustainable, due to a combination of solid waste and high levels of pollutants. Plastic materials are among the most predominant of such pollutants. Based on the need for additional research in this area, this study examines pressures put to rivers and explores trends related to riverine plastic pollution, with a focus on Asia. Apart from the bibliometric analysis, and relying on the collected information, examples describing the drivers of riverine plastic …


Describing And Assessing A New Method Of Approximating Categorical Individual-Level Income Using Community-Level Income From The Census (Weighting By Income Probabilities), Uriel Kim, Siran M. Koroukian, Kurt C. Stange, James C. Spilsbury, Weichuan Dong, Johnie Rose Jul 2022

Describing And Assessing A New Method Of Approximating Categorical Individual-Level Income Using Community-Level Income From The Census (Weighting By Income Probabilities), Uriel Kim, Siran M. Koroukian, Kurt C. Stange, James C. Spilsbury, Weichuan Dong, Johnie Rose

Faculty Scholarship

Objective: To assess a new approach (weighting by “income probabilities [IP]”) that uses US Census data from the patients' communities to approximate individual-level income, an important but often missing variable in health services research. Data Sources: Community (census tract level) income data came from the 2017 5-year American Community Survey (ACS). The patient data included those diagnosed with cancer in 2017 in Ohio (n = 65,759). The reference population was the 2017 5-year ACS Public Use Microdata Sample (n = 564,357 generalizing to 11,288,350 Ohioans). Study Design/Methods: We applied the traditional approach of income approximation using median census tract income …


Using Community-Based System Dynamics To Address Structural Racism In Community Health Improvement, Heidi L. Gullett, Gregory L. Brown, Robin S. Gotler, Kurt C. Stange, Peter S. Hovmand Jul 2022

Using Community-Based System Dynamics To Address Structural Racism In Community Health Improvement, Heidi L. Gullett, Gregory L. Brown, Robin S. Gotler, Kurt C. Stange, Peter S. Hovmand

Faculty Scholarship

Context: Structural racism is a profound determinant of health resulting in pervasive health inequities for people of color. Despite the recognition of structural racism as a complex, dynamic system, we lack a shared vision of the system that would enable identification of solutions for equitable systems transformation. Policy: Through a public health–led community health improvement planning process, a cross-sector consortium implemented community-based system dynamics to provide a systems science lens to guide efforts to eliminate structural racism. Implementation: In group model building sessions involving diverse stakeholders, community-based system dynamics was used to bring together cross-sector stakeholders to create causal loop …


The Property Law Of Tokens, Juliet M. Moringiello, Christopher K. Odinet Jul 2022

The Property Law Of Tokens, Juliet M. Moringiello, Christopher K. Odinet

Faculty Scholarship

Non-fungible tokens—or NFTs, as they are better known—have taken the world by storm. The idea behind an NFT is that by owning a certain thing (specifically, a digital token that is tracked on a blockchain), one can hold property rights in something else (either a real or intangible asset). In the early part of 2021, NFTs for items ranging from a gif of a pop-tart cat with a rainbow tail, to Twitter CEO Jack Dorsey’s first tweet, to a New York Times column (about NFTs!) have sold for millions of dollars over the internet. Promoters assert that NFTs are the …


Poor Writing, Not Specialized Concepts, Drives Processing Difficulty In Legal Language, Eric H. Martinez, Francis Mollica, Edward Gibson Jul 2022

Poor Writing, Not Specialized Concepts, Drives Processing Difficulty In Legal Language, Eric H. Martinez, Francis Mollica, Edward Gibson

Faculty Scholarship

Despite their ever-increasing presence in everyday life, contracts remain notoriously inaccessible to laypeople. Why? Here, a corpus analysis (n ≈10 million words) revealed that contracts contain startlingly high proportions of certain difficult-to-process features–including low-frequency jargon, center-embedded clauses (leading to long-distance syntactic dependencies), passive voice structures, and non-standard capitalization–relative to nine other baseline genres of written and spoken English. Two experiments (N=184) further revealed that excerpts containing these features were recalled and comprehended at lower rates than excerpts without these features, even for experienced readers, and that center-embedded clauses inhibited recall more-so than other features. These findings (a) undermine …


Privity 2.0 May Be Even Better For Tort Defendants, Anita Bernstein Jul 2022

Privity 2.0 May Be Even Better For Tort Defendants, Anita Bernstein

Faculty Scholarship

No abstract provided.


Tribal Labor And Employment Law: The Evolution Of The Navajo Preference In Employment Act, Paul Spruhan Jul 2022

Tribal Labor And Employment Law: The Evolution Of The Navajo Preference In Employment Act, Paul Spruhan

Faculty Scholarship

For nearly 40 years, the Navajo Nation (“Nation”) has regulated labor and employment (except for occupational safety and worker’s compensation) through one statute, the Navajo Preference in Employment Act (NPEA). Despite its seemingly narrow title, the NPEA is a comprehensive law on the subject. First passed in 1985, it has gone through general and specific revisions to reflect tribal leaders’ views on the balance between the interests of employees and employers, both within and outside the tribal government. In its own right, the NPEA is an important manifestation of a Navajo-specific view of labor and employment that every attorney practicing …


The Humanities Strike Back: (E)Esg And Justice Strine Challenge Gamer Shareholder Primacy, David H. Webber Jul 2022

The Humanities Strike Back: (E)Esg And Justice Strine Challenge Gamer Shareholder Primacy, David H. Webber

Faculty Scholarship

Leo E. Strine, Jr. is closing in on Blair and Stout for the undisputed title of all-time top-scoring stakeholderist.3 I don't intend to squander this opportunity to roast and toast him by weighing the pros and cons of basketscoring primacy. Instead, my aim is to surface an overlooked argument in the debate over shareholder primacy and stakeholderism, the case for which has been recently reinvigorated by Strine's work. My argument is this: one underappreciated aspect of shareholder primacy's appeal is that it creates a competition with a single endpoint, basically a game, and that the exhilarating tournament that results, …


Using Mhealth To Improve Adherence And Reduce Blood Pressure In Individuals With Hypertension And Bipolar Disorder (Itab-Cv): Study Protocol For A 2-Stage Randomized Clinical Trial, Jennifer B. Levin, Farren Briggs, Mahboob Rahman, Kurt C. Stange, Douglas Einstadter, Celeste Weise, Carla Conroy, Joy Yala, Ethan Radatz, Martha Sajatovic Jun 2022

Using Mhealth To Improve Adherence And Reduce Blood Pressure In Individuals With Hypertension And Bipolar Disorder (Itab-Cv): Study Protocol For A 2-Stage Randomized Clinical Trial, Jennifer B. Levin, Farren Briggs, Mahboob Rahman, Kurt C. Stange, Douglas Einstadter, Celeste Weise, Carla Conroy, Joy Yala, Ethan Radatz, Martha Sajatovic

Faculty Scholarship

Background: Cardiovascular disease in individuals with mental health conditions such as bipolar disorder is highly prevalent and often poorly managed. Individuals with bipolar disorder face significant medication adherence barriers, especially when they are prescribed multiple medications for other health conditions including hypertension. Poor adherence puts them at a disproportionate risk for poor health outcomes. As such, there is a need for effective interventions to improve hypertension medication adherence, particularly in patients that struggle with adherence due to mental health comorbidity. Methods: This 5-year project uses a 2-stage randomized controlled trial design to evaluate a brief, practical adherence intervention delivered via …


Using Mhealth To Improve Adherence And Reduce Blood Pressure In Individuals With Hypertension And Bipolar Disorder (Itab-Cv): Study Protocol For A 2-Stage Randomized Clinical Trial, Jennifer B. Levin, Farren Briggs, Mahboob Rahman, Kurt Stange, Douglas Einstadter, Celeste Weise, Carla Conroy, Joy Yala, Ethan Radatz, Martha Sajatovic Jun 2022

Using Mhealth To Improve Adherence And Reduce Blood Pressure In Individuals With Hypertension And Bipolar Disorder (Itab-Cv): Study Protocol For A 2-Stage Randomized Clinical Trial, Jennifer B. Levin, Farren Briggs, Mahboob Rahman, Kurt Stange, Douglas Einstadter, Celeste Weise, Carla Conroy, Joy Yala, Ethan Radatz, Martha Sajatovic

Faculty Scholarship

Background: Cardiovascular disease in individuals with mental health conditions such as bipolar disorder is highly prevalent and often poorly managed. Individuals with bipolar disorder face significant medication adherence barriers, especially when they are prescribed multiple medications for other health conditions including hypertension. Poor adherence puts them at a disproportionate risk for poor health outcomes. As such, there is a need for effective interventions to improve hypertension medication adherence, particularly in patients that struggle with adherence due to mental health comorbidity. Methods: This 5-year project uses a 2-stage randomized controlled trial design to evaluate a brief, practical adherence intervention delivered via …


An Argument Against Unbounded Arrest Power: The Expressive Fourth Amendment And Protesting While Black, Karen Pita Loor Jun 2022

An Argument Against Unbounded Arrest Power: The Expressive Fourth Amendment And Protesting While Black, Karen Pita Loor

Faculty Scholarship

Protesting is supposed to be revered in our democracy, considered “as American as apple pie” in our nation’s mythology. But the actual experiences of the 2020 racial justice protesters showed that this supposed reverence for political dissent and protest is more akin to American folklore than reality on the streets. The images from those streets depicted police officers clad in riot gear and armed with shields, batons, and “less than” lethal weapons aggressively arresting protesters, often en masse. In the first week of the George Floyd protests, police arrested roughly 10,000 people, and approximately 78 percent of those arrests were …


Vesting, Jed Handelsman Shugerman Jun 2022

Vesting, Jed Handelsman Shugerman

Faculty Scholarship

"The executive Power shall be vested in a President of the United States of America." The Executive Vesting Clause is one of three originalist pillars for the unitary executive theory, the idea that the President possesses executive powers like removal without congressional limitations (that is, the powers are indefeasible). An underlying assumption is that "vest" connotes a formalist approach to separation of powers rather than a more functional system of Madisonian checks and balances. Assumptions about "vesting" for official powers are likely the result of semantic drift from property rights and ahistoric projections back from the later Marshall Court doctrine …


Langdell And The Foundation Of Classical Contract Law, Daniel P. O'Gorman May 2022

Langdell And The Foundation Of Classical Contract Law, Daniel P. O'Gorman

Faculty Scholarship

No abstract provided.


Chirality In Light–Matter Interaction, Andrew Lininger, Madhav Goel, Michael Hinczewski, Giuseppe Strangi May 2022

Chirality In Light–Matter Interaction, Andrew Lininger, Madhav Goel, Michael Hinczewski, Giuseppe Strangi

Faculty Scholarship

The scientific effort to control the interaction between light and matter has grown exponentially in the last 2 decades. This growth has been aided by the development of scientific and technological tools enabling the manipulation of light at deeply sub-wavelength scales, unlocking a large variety of novel phenomena spanning traditionally distant research areas. Here, the role of chirality in light–matter interactions is reviewed by providing a broad overview of its properties, materials, and applications. A perspective on future developments is highlighted, including the growing role of machine learning in designing advanced chiroptical materials to enhance and control light–matter interactions across …


Atomically Dispersed Janus Nickel Sites On Red Phosphorus For Photocatalytic Overall Water Splitting, Shuai Xu, Clemens Burda May 2022

Atomically Dispersed Janus Nickel Sites On Red Phosphorus For Photocatalytic Overall Water Splitting, Shuai Xu, Clemens Burda

Faculty Scholarship

Single-atom nickel catalysts hold great promise for photocatalytic water splitting due to their plentiful active sites and cost-effectiveness. Herein, we adopt a reactive-group guided strategy to prepare atomically dispersed nickel catalysts on red phosphorus. The hydrothermal treatment of red phosphorus leads to the formation of P−H and P−OH groups, which behave as the reactive functionalities to generate the dual structure of single-atom P−Ni and P−O−Ni catalytic sites. The produced single-atom sites provide two different functions: P−Ni for water reduction and P−O−Ni for water oxidation. Benefitting from this specific Janus structure, Ni-red phosphorus shows an elevated hydrogen evolution rate compared to …


The Potentials And Challenges Of Zoom Live Theatre During Coronavirus Lockdown: Pandemic Therapy And Corona Chicken (Part Two), Khaled Mostafa Karam May 2022

The Potentials And Challenges Of Zoom Live Theatre During Coronavirus Lockdown: Pandemic Therapy And Corona Chicken (Part Two), Khaled Mostafa Karam

Faculty Scholarship

This study discusses the potentials and challenges of Zoom theatre performances during the lockdown caused by the Covid-19 pandemic. It examines the utilization and applicability of videoconferencing software Zoom, and other streaming software compatible with it, in creating a viable performance option for theatre practitioners and audiences during mandatory social distancing. Such software can be a strategy for social inclusion, alleviating the adverse effects of extended quarantine. The article also discusses the technical and performative aspects of Zoom theatre, pointing out its pros and cons. It uses a critical and analytical approach to performances of two Zoom plays, Pandemic Therapy …


Omicron Infection Milder In Nursing Home Residents, Robin L.P. Jump May 2022

Omicron Infection Milder In Nursing Home Residents, Robin L.P. Jump

Faculty Scholarship

No abstract provided.


A Mixed-Methods, Cross-Sectional Study Of Perceived Stigma Among Ugandans With Epilepsy, Carol Blixen, Martha Sajatovic Apr 2022

A Mixed-Methods, Cross-Sectional Study Of Perceived Stigma Among Ugandans With Epilepsy, Carol Blixen, Martha Sajatovic

Faculty Scholarship

Background: Epilepsy is associated with stigma and negatively impacts the lives of people living with epilepsy (PLWE) and their immediate families. More understanding of the stigma and discrimination experienced by PLWE in sub-Saharan Africa is needed. Methods: In a cross-sectional, mixed methods study, forty- eight PLWE who met the study inclusion criteria were enrolled. In depth interviews and focus group discussions were conducted and were audiotaped and transcribed verbatim. Analysis was conducted using a thematic, constant comparative approach with an emphasis on dominant themes. Perceived stigma was measured using the Kilifi epilepsy stigma score. Associations between socio-demographic factors and Kilifi …


The Nested Embryonic Dorsal Domains Of Bmp-Target Genes Are Not Scaled To Size During The Evolution Of Drosophila Species, Juan Sebastian Chahda, Priscilla Ambrosi, Claudia M. Mizutani Apr 2022

The Nested Embryonic Dorsal Domains Of Bmp-Target Genes Are Not Scaled To Size During The Evolution Of Drosophila Species, Juan Sebastian Chahda, Priscilla Ambrosi, Claudia M. Mizutani

Faculty Scholarship

Egg size is a fast-evolving trait among Drosophilids expected to change the spatial distribution of morphogens that pattern the embryonic axes. Here we asked whether the patterning of the dorsal region of the embryo by the Decapentaplegic/Bone Morphogenetic Protein-4 (DPP/BMP-4) gradient is scaled among Drosophila species with different egg sizes. This region specifies the extra-embryonic tissue amnioserosa and the ectoderm. We find that the entire dorsal region scales with embryo size, but the gene expression patterns regulated by DPP are not proportional, suggesting that the DPP gradient is differentially scaled during evolution. To further test whether the DPP gradient can …