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Articles 151 - 180 of 6488
Full-Text Articles in Entire DC Network
Premenopausal Transition In Neurodivergent Women With Musculoskeletal Syndromes: Mechanisms, Risks, And Neuroinclusive Therapeutics, Piper Hutson, James Hutson
Premenopausal Transition In Neurodivergent Women With Musculoskeletal Syndromes: Mechanisms, Risks, And Neuroinclusive Therapeutics, Piper Hutson, James Hutson
Faculty Scholarship
Neurodivergent women with chronic musculoskeletal syndromes experience disproportionate premenopausal symptom burdens that are poorly characterized in extant clinical paradigms and practice. The compounded interplay of estrogen fluctuations in premenopause with sensory–executive differences and baseline nociception from joint or connective-tissue pathology yields intensified pain, mood dysregulation, and functional decline. Evidence indicates estrogen modulates nociception, neuroinflammation, bone remodeling, and monoaminergic signaling; premenopausal variability magnifies pain, affective lability, and cognitive drift—effects accentuated in autism and ADHD. Coexisting hypermobility, fibromyalgia, or connective-tissue disorders compromise joint integrity and proprioception, increasing susceptibility to estrogen-dependent changes in bone microarchitecture and tendon homeostasis. This article advances an integrative …
Quilting As Reproductive Justice Information Activism, Liz Chenevey
Quilting As Reproductive Justice Information Activism, Liz Chenevey
Faculty Scholarship
No abstract provided.
Joinder, Not Jurisdiction: Toward A New Theory Of Standing, Adam N. Steinman
Joinder, Not Jurisdiction: Toward A New Theory Of Standing, Adam N. Steinman
Faculty Scholarship
This Article builds on an important development in the Supreme Court’s standing jurisprudence to propose a novel theory that would allow more meaningful access to federal courts while vindicating legitimate separation-of-powers concerns. In its recent decision in TransUnion LLC v. Ramirez, the Supreme Court endorsed a theory of standing based on Article II, writing that litigation between private parties—even when explicitly authorized by Congress—can run afoul of the executive branch’s interest in “how to prioritize and how aggressively to pursue legal actions against defendants who violate the law.” This Article II move has been justifiably criticized. But it is …
Harnessing The Electronic Health Record To Identify And Enroll People With Epilepsy Into A Self-Management Program: Implementation And Scalability In A Clinical Setting, Clara Adeniyi, Richard Barigye, Jessica Black, Nicole Fiorelli, Carrie Rogers, Martha Sajatovic
Harnessing The Electronic Health Record To Identify And Enroll People With Epilepsy Into A Self-Management Program: Implementation And Scalability In A Clinical Setting, Clara Adeniyi, Richard Barigye, Jessica Black, Nicole Fiorelli, Carrie Rogers, Martha Sajatovic
Faculty Scholarship
Rationale: “Self-management for people with epilepsy and a history of negative health events” (SMART) is an 8-week, remotely delivered, Epilepsy Self-Management (ESM) program. The ongoing EXPANDing self-management support in healthcare networks (EXPAND) initiative leveraged the Electronic Health Record (EHR) to identify SMART candidates, simplify recruitment, and reduce staff workload. Methods: This is an ongoing implementation effort at two Level 4 Epilepsy Centers (Iowa and Cincinnati) using the Epic EHR which follows 9326 People With Epilepsy (PWE). The EHR uses pre-visit screening to identify PWE with a recent seizure; barriers to medication adherence; depression symptoms; age 18–25; or residence in rural …
Social Cognition As A Mediator Between Neurocognition And Functional Outcome In Early Course Schizophrenia, Anju Kotwani, Jessica A. Wojtalik, Douglas D. Gunzler, Wilson J. Brown, Rochanne L. Honarvar, Martha Sajatovic
Social Cognition As A Mediator Between Neurocognition And Functional Outcome In Early Course Schizophrenia, Anju Kotwani, Jessica A. Wojtalik, Douglas D. Gunzler, Wilson J. Brown, Rochanne L. Honarvar, Martha Sajatovic
Faculty Scholarship
Social cognition is an established mediator between neurocognition and functional outcome in schizophrenia, but there is limited evidence for this model specifically in the early course, which is a critical window for intervention to reduce long-term disability. This study aimed to test the social cognition mediator model in the early course of schizophrenia and identify social cognitive subdomains that may have stronger indirect effects on the relationship between neurocognition and functional outcome. This secondary analysis utilized baseline cognitive and functional outcome data from a cognitive remediation trial for outpatients with early course schizophrenia (N = 102). A path analysis approach …
Patterns And Implications Of Missed Injuries On Computed Tomography Imaging In Older Blunt Trauma Patients, Arnav Mahajan, Vanessa P. Ho
Patterns And Implications Of Missed Injuries On Computed Tomography Imaging In Older Blunt Trauma Patients, Arnav Mahajan, Vanessa P. Ho
Faculty Scholarship
Background: Older adults sustain disproportionately morbid injuries from low energy mechanisms, yet guidance around computed tomography imaging is lacking for this demographic. We hypothesize that current imaging practices may lead to potentially missed injuries, increasing morbidity and mortality. Methods: A secondary analysis of a prospective multicenter study (11/2020–12/2021) of older blunt trauma patients was performed. Suboptimal imaging was defined as a mismatch between final injury diagnosis and initial computed tomography imaging. We compared optimally vs not optimally imaged patients to determine factors associated with suboptimal imaging and examined mortality, hospital length of stay, and critical care use with a multivariable …
Social Cognition As A Mediator Between Neurocognition And Functional Outcome In Early Course Schizophrenia, Anju Kotwani, Jessica A. Wojtalik, Douglas D. Gunzler, Wilson J. Brown, Rochanne L. Honarvar, Martha Sajatovic
Social Cognition As A Mediator Between Neurocognition And Functional Outcome In Early Course Schizophrenia, Anju Kotwani, Jessica A. Wojtalik, Douglas D. Gunzler, Wilson J. Brown, Rochanne L. Honarvar, Martha Sajatovic
Faculty Scholarship
Social cognition is an established mediator between neurocognition and functional outcome in schizophrenia, but there is limited evidence for this model specifically in the early course, which is a critical window for intervention to reduce long-term disability. This study aimed to test the social cognition mediator model in the early course of schizophrenia and identify social cognitive subdomains that may have stronger indirect effects on the relationship between neurocognition and functional outcome. This secondary analysis utilized baseline cognitive and functional outcome data from a cognitive remediation trial for outpatients with early course schizophrenia (N = 102). A path analysis approach …
Retinoid Dynamics In Vision: From Visual Cycle Biology To Retina Disease Treatments, Jaclyn Swigris, Made Airanthi K. Widjaja-Adhi, Marcin Golczak
Retinoid Dynamics In Vision: From Visual Cycle Biology To Retina Disease Treatments, Jaclyn Swigris, Made Airanthi K. Widjaja-Adhi, Marcin Golczak
Faculty Scholarship
Light perception is a biological process that facilitates a profound interaction between the external world and the internal functions of living organisms. It begins with the absorption of photons with specialized visual pigments that contain vitamin A-derived chromophores. The light energy triggers the photoisomerization of the visual chromophore, initiating a cascade of signaling events that ultimately convert light into electrical signals interpreted as vision. However, the sustainability of vision relies on the continuous supply of the visual chromophore, which is maintained through light-dependent and light-independent processes. The importance of these processes is underscored by numerous blinding retinal diseases linked to …
Academic Research And (Google Or Reddit): A Librarian-Faculty Collaboration To Improve Student Source Engagement, Stephanie Redekop, Olivia Hobbs
Academic Research And (Google Or Reddit): A Librarian-Faculty Collaboration To Improve Student Source Engagement, Stephanie Redekop, Olivia Hobbs
Faculty Scholarship
Effective source use is a critical skill for first-year writing students because it prepares them for academic, professional, and civic engagement; however, existing research demonstrates that selecting appropriate sources and engaging them insightfully remains a significant challenge. While students struggle with the combined pressures to read, evaluate, and synthesize scholarly sources, we argue that online media including news articles, opinion pieces, and social media posts are a potent but underutilized resource for building students’ competence and confidence with source use. In this article, we present the methods that we have collaboratively developed as an instruction librarian and a first-year writing …
Stakeholder Views On Lessons Learned For The Antimicrobial Resistance Panel From Previous International Science Panels [Version 1], Iruka N. Okeke, Ayodele A. Akinyele, Javier Guzman, Kevin Outterson
Stakeholder Views On Lessons Learned For The Antimicrobial Resistance Panel From Previous International Science Panels [Version 1], Iruka N. Okeke, Ayodele A. Akinyele, Javier Guzman, Kevin Outterson
Faculty Scholarship
The United Nations General Assembly called in September 2024 for the establishment of an independent panel for actionable evidence against antimicrobial resistance (IPEA). The task of designing the panel was given to the Quadripartite Joint Secretariat (QJS) on Antimicrobial Resistance (AMR) with a delivery timeline of 15 months. To promote stakeholder thought and input around what this panel should look like and how it should work, which could feed into the QJS’s consultation process, we independently commissioned seven papers to examine lessons that could be learned from other high-level scientific panels. We then called a convening of stakeholders that were …
Amicus In Trump V. Cook: The Fed, Offices As Property, And The Meaning Of “Cause”, Jed Handelsman Shugerman
Amicus In Trump V. Cook: The Fed, Offices As Property, And The Meaning Of “Cause”, Jed Handelsman Shugerman
Faculty Scholarship
The Federal Reserve Act states that “each member shall hold office for a term of fourteen years from the expiration of the term of his predecessor, unless sooner removed for cause by the President.” 12 U.S.C. § 242. Based on the historical record, when Congress creates an office with a fixed term of years and protects against removal without “cause,” Congress has both granted “a constitutionally protected property interest” under the Fifth Amendment (that cannot be taken away without “due process”) and extended a statutory entitlement to receive fair notice and a meaningful opportunity to respond before any removal may …
Organizing For Abolition In Ice Custody, Sarah R. Sherman-Stokes
Organizing For Abolition In Ice Custody, Sarah R. Sherman-Stokes
Faculty Scholarship
The final Immigration and Customs Enforcement (“ICE”) detainees were released from the Irwin County Detention Center in early September 2021.2 A court did not order the end of ICE detention at Irwin. A social movement, led by people detained at Irwin, had a pronounced impact on the epistemological landscape and changed both normative principles and public opinion.3 Those detained at Irwin organized and acted to create new understanding of law and protect their rights in ways that courts and legislatures could not. This Essay tells the story of that demosprudential project; a dialectic between legal elites and people …
College Students' Perceptions Of Artificial Intelligence (Ai) Risks And Benefits In Pakistan, Rauf Arif, Muhammad Ittefaq, Lamia Zia
College Students' Perceptions Of Artificial Intelligence (Ai) Risks And Benefits In Pakistan, Rauf Arif, Muhammad Ittefaq, Lamia Zia
Faculty Scholarship
With the rapid advancements in technology over the past 2 decades, it has become crucial to understand people’s attitudes toward artificial intelligence (AI) adoption and its associated risks. Given the increasing access to the AI technologies, it is imperative to examine how young people in non-Western societies like Pakistan perceive AI risks and benefits. We conducted an online survey of college students who had used AI technology in the past 6 months. The results of our study indicate that the majority of college students view AI technology positively and perceive it as an opportunity to enhance workplace productivity. In addition, …
Automated Raft Polymerization Using Batch, Increment, And Continuous Addition Modes To Enhance Properties Of Fluorescent Polymers, Sophia Beilharz, Konpal Raheja, Metin Karayilan
Automated Raft Polymerization Using Batch, Increment, And Continuous Addition Modes To Enhance Properties Of Fluorescent Polymers, Sophia Beilharz, Konpal Raheja, Metin Karayilan
Faculty Scholarship
We report an automated RAFT copolymerization strategy using a Chemspeed robotic platform capable of executing batch, incremental, and continuous monomer addition workflows under inert conditions. Copolymerizations of oligo(ethylene glycol) acrylate with fluorescein o-acrylate were performed in different solvents with reaction kinetics monitored via time-resolved1 H NMR spectroscopy. Continuous addition reactions conducted at rates from 0.3 to 1.0 mL/hr enabled compositional tuning and control over monomer sequence. This automated workflow has a potential to provide a high-throughput platform for polymer design, kinetic profiling, and material property optimization with minimal manual intervention.
Molecular Mechanisms Of Iron Metabolism And Overload, Aditi Tayal, Jasmeen Kaur, Robert W. Maitta
Molecular Mechanisms Of Iron Metabolism And Overload, Aditi Tayal, Jasmeen Kaur, Robert W. Maitta
Faculty Scholarship
Iron represents an essential element required for normal physiologic processes throughout organ systems. A vast network of transporters is involved not only in uptake of this element but in processing, oxidation, and recycling to maintain it in a tight balance to avoid excess storage. This complex network of transporters, including heme and ferroportin, among many others, are responsible for facilitating inter-organ tissue iron exchange and availability, contributing to overall heme homeostasis. However, exposure to high levels of iron can overwhelm compensatory mechanisms that result in its accumulation and toxicity. This is the case of patients with genetic diseases such as …
Barriers And Enablers Of Early Health-Seeking Behaviour Among Women With Preeclampsia And Eclampsia: A Qualitative Study At A National Referral Hospital In Uganda, Shirley Moore, Martha Sajatovic
Barriers And Enablers Of Early Health-Seeking Behaviour Among Women With Preeclampsia And Eclampsia: A Qualitative Study At A National Referral Hospital In Uganda, Shirley Moore, Martha Sajatovic
Faculty Scholarship
Background: Globally, 2–8% of women experience hypertensive disorders in pregnancy (HDPs), including preeclampsia and eclampsia, which are the second leading cause of maternal mortality and morbidity. According to the management protocol for preeclampsia in Uganda, weekly follow-up is recommended for women with preeclampsia without severe features who are below 37weeks of gestation; however, this has not been feasible to most cases of preeclampsia/eclampsia (PE/E). There is still limited information describing barriers and enablers of early health-seeking behaviour amongst women with PE/E, yet this is needed to improve their healthcare. This study explored the barriers and enablers of early health-seeking behaviour …
A 6-Month, Prospective Randomized Controlled Trial Of The Targeted Management (Team) Intervention Vs. Enhanced Treatment As Usual Among Ugandans At Risk For Stroke, Carla Conroy, Joy Yala, Christopher J. Burant, Shirley Moore, Martha Sajatovic
A 6-Month, Prospective Randomized Controlled Trial Of The Targeted Management (Team) Intervention Vs. Enhanced Treatment As Usual Among Ugandans At Risk For Stroke, Carla Conroy, Joy Yala, Christopher J. Burant, Shirley Moore, Martha Sajatovic
Faculty Scholarship
Background Among low and middle-income countries, especially in Sub-Saharan Africa, the stroke burden is severe, with increasing trends in stroke incidence, prevalence, and mortality. Aims This 6-month, prospective randomized controlled trial (RCT) compared a novel stroke risk reduction approach (TargetEd manAgeMent Intervention (TEAM)) vs. Enhanced Treatment as Usual (ETAU) in 247 Ugandans at risk for stroke. Methods Participants, enrolled across 3 Ugandan sites, were adults with high stroke risk. The primary outcome was a change in systolic blood pressure (SBP) from baseline to 6-month follow-up. Secondary outcomes included changes from baseline to 6 months on diastolic BP (DBP), serum lipids, …
Transmission Patterns That Reduce Population Size Without Increasing Disease Prevalence: Masting And Chronic Wasting Disease In White-Tailed Deer, Virginia Kanzinger, Karen C. Abbott
Transmission Patterns That Reduce Population Size Without Increasing Disease Prevalence: Masting And Chronic Wasting Disease In White-Tailed Deer, Virginia Kanzinger, Karen C. Abbott
Faculty Scholarship
How individuals use space and, thus, the rate and the nature of their interactions with others are shaped by their environment. Exogenous changes that alter aggregation patterns, such as resource pulses, can therefore have a significant impact on seemingly unrelated processes like disease spread. White-tailed deer (Odocoileus virginianus) aggregate in oak forests during mast events, and chronic wasting disease (CWD) transmission patterns vary with deer density, so we hypothesize a link between the masting cycle and CWD dynamics. We investigate various possible effects of masting on deer, including shifts to more frequency-dependent CWD transmission due to aggregation, as well as …
Challenges And Opportunities On Achieving An Adequate Delivery Efficiency And Immunogenicity With Peptide-Based Anticancer Vaccines, Yanqing Wang, Da Sun, Victoria Laney, Hong Wang, Zheng Rong Lu
Challenges And Opportunities On Achieving An Adequate Delivery Efficiency And Immunogenicity With Peptide-Based Anticancer Vaccines, Yanqing Wang, Da Sun, Victoria Laney, Hong Wang, Zheng Rong Lu
Faculty Scholarship
Peptide vaccines are based on small peptide segments that contain antigenic epitopes recognizable by immune cells. Unlike traditional vaccines, they include only specific antigenic epitopes rather than entire pathogens or proteins. They are recognized, internalized, processed, and presented by antigen-presenting cells, such as dendritic cells, and subsequently presented to T cells, triggering an immune response. Peptide-based vaccines, an innovative regimen of cancer immunotherapy, have shown the potential to elicit target-specific anti-tumor immune responses, however their therapeutic efficacy is often diminished by their poor stability, rapid clearance from circulation, low immunogenicity, individual variability, and immune escape. In recent years, significant advancements …
Planetary Health: At The Crossroads Of Cvd Prevention, Tasveer Khawaja, Sanjay Rajagopalan
Planetary Health: At The Crossroads Of Cvd Prevention, Tasveer Khawaja, Sanjay Rajagopalan
Faculty Scholarship
Purpose of Review: To highlight important recent findings demonstrating the interconnectedness of planetary and human health with a focus on cardiovascular disease. Recent Findings: Data continue to demonstrate a clear interconnectedness between the health of the planet and human health, with cardiovascular disease as an important outcome. The central roles of air pollution, non-optimal temperatures, water/waste management, and food/biodiversity are highlighted. We also highlight the clear opportunity for healthcare organizations to facilitate change that will yield positive environmental and patient outcomes. Summary: The undeniable interconnectedness of the health of the planet and human health serves as a call to action …
Increasing The Feasibility, Impact, And Equity Of The Medicare Annual Wellness Visit (Awv) With A Practice Tailored Awv Intervention: A Stepped Wedge Clinical Trial Protocol, Chi-Hong Tseng, Neil S. Wenger
Increasing The Feasibility, Impact, And Equity Of The Medicare Annual Wellness Visit (Awv) With A Practice Tailored Awv Intervention: A Stepped Wedge Clinical Trial Protocol, Chi-Hong Tseng, Neil S. Wenger
Faculty Scholarship
Background Older adults vastly underutilize evidence-based preventive health services and screenings that reduce illness, morbidity and mortality. The free-to-patient Medicare Annual Wellness Visit (AWV) is an opportunity to enhance preventive healthcare use, but also is underused. Objectives To evaluate the effect of a practice-tailored intervention on the sustained use of Medicare AWVs and on guideline-recommended preventive services and racial/ethnic disparities in 3 types of practice settings. Methods This is a stepped wedge cluster randomized controlled trial. The intervention will be implemented at the practice level in 24 primary care practices across the country (8 community-based, 8 academic, and 8 serving …
Mitigating Ai Bias With Prompt Augmentation, Verónica C. Gonzales
Mitigating Ai Bias With Prompt Augmentation, Verónica C. Gonzales
Faculty Scholarship
Large-language-model (“LLM”) outputs are inevitably shaped by assumptions, biases, and attitudes rooted in racism and other systemic inequities embedded in the civil-law tradition. This Equity-in-Justice CLE focuses on helping civil legal service providers recognize and work to eliminate biases in generative AI outputs through equity-centered prompt augmentation and engineering. These small, cost-free interventions re-orient LLMs assistance toward fairness, cultural competency, and client-centered outcomes. Participants leave with an action plan for embedding anti-bias safeguards in everyday research, drafting, and client communication tasks.
Cultivating Identity, Workforce Readiness, And Heutagogical Lifelong Learning: The Case For Student-Trained Ai Agents In Postsecondary Education, James Hutson
Faculty Scholarship
The accelerated integration of human-centered artificial intelligence and human-computer intelligent interaction (HCII) into postsecondary education has inaugurated a paradigm shift in how learners develop cognitive, socio emotional, and professional competencies. This article argues that requiring students to iteratively build and refine custom AI agents—digital “clones” or GPTs trained on their evolving beliefs, knowledge, values, and interests addresses three pressing challenges facing contemporary higher education. First, the process of self-modeling via agent training compels deep self-reflection, fostering socio-economic development and identity formation during the critical neurodevelopmental period that extends into the mid-twenties. Second, as industry trends increasingly prioritize the creation of …
Complex Factors Impacting Smoking Behavior In Cancer Survivors With Food Insecurity, Madeline C. Castele, Kareena Shah, Avianna Thompson, Jin E. Kim-Mozeleski
Complex Factors Impacting Smoking Behavior In Cancer Survivors With Food Insecurity, Madeline C. Castele, Kareena Shah, Avianna Thompson, Jin E. Kim-Mozeleski
Faculty Scholarship
Objectives: Tobacco use remains prevalent among people with social needs, such as food insecurity. In this study, we aimed to understand the complex experiences of low-income cancer survivors with food insecurity who smoke tobacco, to identify the unique smoking cessation needs for this group. Methods: We conducted in-depth, semi-structured qualitative interviews with 40 adults experiencing food insecurity who continued smoking after a cancer diagnosis. Interviews focused on smoking behaviors, cessation interest, cancer experiences, and financial circumstances. We analyzed the data using reflexive thematic analysis. Results: In this sample of cancer survivors (50% female, mean age 42 years, 60% black/African American, …
Defending Rule-Of-Law Minimalism, Ashraf Ahmed
Defending Rule-Of-Law Minimalism, Ashraf Ahmed
Faculty Scholarship
The rule of law is a political idea that counts only allies and no enemies. As a popular concept, the rule of law inspires broad rhetorical support. In the United States, for instance, liberals and conservatives alike invoke the “rule of law” as a normative lodestar in political conflicts. Liberals targeting the Trump administration cast their lawsuits as a defense of the rule of law. In parallel fashion, conservatives often charge creative readings of old statutes and ambitious administrative action as departures from the rule of law. It seems that any viable political venture must defend, advance, or at least …
The Origins Of "The Rule Of Law", Jeremy K. Kessler
The Origins Of "The Rule Of Law", Jeremy K. Kessler
Faculty Scholarship
This Article offers a novel account of the origins of “the rule of law” in the English-speaking world. The phrase itself likely entered the language as a literal translation of the Latin regula juris. Prior to the early seventeenth century, however, the phrase appears to have been used exclusively to refer to the specific legal rule or maxim most relevant to the resolution of a particular kind of dispute. The more general and abstract use of the phrase – to refer to an ideal of political morality or an ideal type of governance – first appeared in the public …
Developing A Novel Patient-Centered Definition Of Severe Maternal Morbidity, Adina R. Kern-Goldberger
Developing A Novel Patient-Centered Definition Of Severe Maternal Morbidity, Adina R. Kern-Goldberger
Faculty Scholarship
Background: Defining, preventing, and evaluating severe maternal morbidity (SMM) has become an important component of obstetric care delivery, but existing frameworks for SMM do not account for how patients perceive and experience morbidity. Objective: This study evaluated patient values and perceptions related to maternal pregnancy complications with the goal of devising a patient-centered maternal morbidity composite. Study Design: This 2-part sequential qualitative to quantitative mixed-methods study first involved semi-structured interviews of postpartum patients recruited from an urban, academic hospital prior to discharge from the delivery admission with purposive sampling by race and mode of delivery. Qualitative data around patient-perceived adverse …
Teaching Transactional Skills And Lawyering Values To First-Year Students Through An Affordable-Housing Deal, Laura E. D'Amato
Teaching Transactional Skills And Lawyering Values To First-Year Students Through An Affordable-Housing Deal, Laura E. D'Amato
Faculty Scholarship
With the anticipated launch of the NextGen bar exam next year, transactional lawyering skills are enjoying increased attention in first-year law school curricular development. At the same time, recent amendments to ABA Rule 303 have made it essential for new law students to learn about the profession’s core values and responsibilities. While these evolving priorities open the door to pedagogical innovation, incorporating two distinct topics into an already packed curriculum can be challenging. This article explores how a simulated affordable-housing financing deal has served as a cohesive foundation for introducing first-year students to transactional skills and core professional values.
Classifying Heterogeneous Cooperation In Social Dilemmas: Experimental Evidence And Simulation Insights, Sining Wang
Classifying Heterogeneous Cooperation In Social Dilemmas: Experimental Evidence And Simulation Insights, Sining Wang
Faculty Scholarship
In this paper, we introduce a revealed strategy method to capture heterogeneous behavioral patterns in repeated public goods experiments. This method identifies an individual’s strategic type—a stable decision-making tendency in interactive settings—by analyzing behavioral profiles. We conduct a repeated public goods game to collect participants’ behavioral data and then apply both k-medians and hierarchical clustering algorithms to classify them into five distinctive types: free riders, strong cooperators, above-average conditional cooperators, below-average conditional cooperators, and hump-shaped players. These classifications are then used to construct and calibrate an agent-based simulation model. Our simulation results suggest that policies targeting how conditional cooperators respond …
Immunosuppressive Formulations For Immunological Defense Against Traumatic Brain Injury, Abhirami Thumsi, Abhinav P. Acharya, Jeffrey Capadona, Sanmoy Pathak, Taravat Khodaei, Madan Mohan Chandra Sekhar Jaggarapu, Abhirami P. Suresh
Immunosuppressive Formulations For Immunological Defense Against Traumatic Brain Injury, Abhirami Thumsi, Abhinav P. Acharya, Jeffrey Capadona, Sanmoy Pathak, Taravat Khodaei, Madan Mohan Chandra Sekhar Jaggarapu, Abhirami P. Suresh
Faculty Scholarship
Traumatic brain injury (TBI) and subsequent neurodegeneration is partially driven by chronic inflammation both locally and systemically. Yet, current clinical intervention strategies do not mitigate inflammation sequelae necessitating the development of innovative approaches to reduce inflammation and minimize deleterious effects of TBI. Herein, a subcutaneous formulation based on polymer of alpha-ketoglutarate (paKG) delivering glycolytic inhibitor PFK15 (PFKFB3 inhibitor, a rate limiting step in glycolysis), alpha-ketoglutarate (to fuel Krebs cycle) and peptide antigen from myelin proteolipid protein (PLP139-151) is utilized as the prophylactic immunosuppressive formulation in a mouse model of TBI. In vitro, the paKG(PFK15+PLP) formulation stimulates proliferation of immunosuppressive regulatory …