Digital Commons Network^™

Cgas/Sting-Independent Induction Of Type I Interferon By Inhibitors Of The Histone Methylase Kdm5b, Monica M. Montano, I. Ju Yeh, Wannarasmi Ketchart

Faculty Scholarship

Studies support the role of hexamethylene bis-acetamide [HMBA] induced protein 1 (HEXIM1) as a tumor suppressor. We previously reported that the histone demethylase, KDM5B, inhibits the expression of HEXIM1, and KDM5B inhibitors (KDM5Bi) upregulate HEXIM1 expression. As a consequence, KDM5Bi inhibited cell proliferation, induced differentiation, potentiated sensitivity to cancer chemotherapy, and inhibited breast tumor metastasis. HEXIM1 is crucial for the regulation of triple-negative breast cancer (TNBC) phenotype by KDM5Bi. Type I Interferon (IFN-I) employs the immune system in the tumor microenvironment to restrict tumor growth. Moreover, therapeutic approaches (including mainstay chemotherapy) engage IFN-I signaling. We report herein that HEXIM1 and …

The Diverse Roles Of Complex Glycans In Synapse Development And Function, Peng Zhang

Faculty Scholarship

Protein glycosylation is a critical post-translational modification that mediates a myriad of biological functions, including neuronal development in the brain. Stages of neuronal development include neurogenesis, neuronal migration, axonal guidance, synapse formation, and activity-dependent synaptic remodeling and plasticity. Among these, synapse formation and plasticity are essential to establish and maintain neuronal circuits for proper brain function. Yet, the physiological role of glycans at synapses remains poorly understood. This is especially true for complex glycans, known for decades to be present on the cell surface or extracellular matrix, including the microenvironment around synapses. In this review, we highlight recent examples of …

Integrating Pre-Colonial Indigenous Australian Art Into Global Art History, Allison Bell, James Hutson

Faculty Scholarship

Art history as a discipline remains dominated historically through Eurocentric frameworks, systematically marginalizing Indigenous artistic traditions, particularly pre-colonial Australian Aboriginal art. Despite evidence of profound antiquity and cultural richness, such art often occupies peripheral spaces in global narratives. This article addresses these limitations through an interdisciplinary approach, integrating precise archaeological dating methods—including radiocarbon analysis of mud wasp nests and uranium-series dating—with detailed art historical inquiry. Case studies focus specifically on landmark findings, such as the Gwion Gwion rock paintings in the Kimberley region (over 16,000 years old) and Australia’s oldest known in-situ kangaroo painting, dated approximately 17,300 years old. Comparative …

Eviction Sealing: A Lifeline In The Fight For Housing Justice, Allison Freedman

Faculty Scholarship

In January 2023, the White House released a Blueprint for a Renters Bill of Rights. The Blueprint called for immediate sealing of eviction case filings to reduce the likelihood that tenants would be locked out of future housing opportunities without the chance to defend themselves. Shortly thereafter, the Federal Trade Commission and the Consumer Financial Protection Bureau issued a request for public comment on how the use of eviction records and screening algorithms may affect tenant housing opportunities and drive discriminatory outcomes. The eviction crisis, its discriminatory effects, and the idea that sealing eviction records may provide a solution to …

Building Layered Defenses To Reduce Illegal Gun Violence, Samuel Kan

Faculty Scholarship

This article examines a multifaceted approach to reducing illegal gun violence in the United States through the implementation of layered defense strategies. While acknowledging the constitutional protections afforded by the Second Amendment, the author argues that targeted legislative and community-based interventions can effectively reduce gun violence without infringing on lawful gun ownership rights. The analysis explores several key defensive measures, including extreme risk laws (risk protection orders), which allow for temporary firearm removal from individuals posing credible threats to themselves or others—a practice recently upheld by the Supreme Court in United States v. Rahimi. The article further examines the constitutional …

The Antitrust–Copyright Interface In The Age Of Generative Artificial Intelligence, Daryl Lim, Peter K. Yu

Faculty Scholarship

The U.S. government's antitrust actions against Big Tech have recently surged in response to the growing dominance of Amazon, Apple, Google, Meta, and Microsoft. In fall 2023, the Federal Trade Commission filed a controversial submission in response to the U.S. Copyright Office's request for comments on artificial intelligence (AI) and copyright. This submission hinted at the agency's eagerness to fully deploy its enforcement powers in the AI sector, including targeting AI developers that have used copyrighted works without authorization to train AI models.

This article examines the changing interface of antitrust and copyright law in the age of generative AI. …

The "Not Seen" Effect Of International Financial Centers: Innovation In The Global Financial Ecosystem, Charlotte Ku, Andrew P. Morriss

Faculty Scholarship

International Financial Centers (IFCs) are hubs of legal and financial innovation, developing specialized frameworks that facilitate cross-border investment, enhance global capital mobility, and support economic growth. Through jurisdictional competition, professional clustering, and adaptive regulatory frameworks, IFCs have pioneered legal structures that enable enterprises of all sizes to participate in the global economy. Using case studies of the International Business Company, the Limited Liability Company, the Protected Cell Company, and advances in trust law and applying the theoretical frameworks of social scientist Richard Florida and psychologist Mihalyi Csikszentmihalyi, this Article illustrates how IFCs serve as laboratories for financial experimentation, generating widely …

A New Parlor Is Open: Microfeminisms Are Needed In Law School To Combat Gender Bias, Stephanie J. Thompson

Faculty Scholarship

A recent viral trend on TikTok has spotlighted women attorneys who are leveraging microfeminisms to uplift other women and challenge entrenched gender norms within the workplace. The hashtag #microfeminism has garnered over a billion views, underscoring a growing interest in this nuanced form of advocacy. Microfeminism encompasses the subtle, everyday actions individuals—regardless of gender—take to promote gender equity and disrupt traditional expectations, both personally and professionally. In contrast to broader feminist movements that often seek systemic reform, microfeminism focuses on the interpersonal and individual level, recognizing the transformative potential of seemingly small gestures. This Article aims to initiate a critical …

Law And Political Economy: Missing Markets, Missing Law, And Missing Political Economy, Andrew P. Morriss, Roger E. Meiners

Faculty Scholarship

This Article critiques the "Law and Political Economy" (LPE) framework. It aims to challenge the Law and Economics (L&E) approach. We argue that LPE lacks a coherent theoretical foundation and fails to engage with empirical evidence, rendering its critiques of markets, law, and political economy incomplete and unpersuasive. By contrast, L&E provides robust analytical tools and a well-developed understanding of legal and market dynamics, is grounded in empirical research, and has theoretical consistency. We illustrate these points through historical examples in the evolution of L&E and suggest ways LPE can evolve to offer a meaningful alternative. Rigorous intellectual competition will …

Pragmatics And Textualism, Lawrence B. Solum

Faculty Scholarship

In theoretical linguistics the word “pragmatics” refers to the roles of context and communicative intentions in the production of meaning. Those roles include contextual disambiguation and the communication of implicit content via “pragmatic enrichment.” Textualism is sometimes characterized as the view that the meaning of statutory texts should not take context into account, but that characterization is misleading. Not only do self-identified textualists explicitly maintain that context should be considered when interpreting statutes—all good textualists must do so. Absent consideration of context, the meaning of statutory texts would be pervasively ambiguous, sparse, and incomplete. Good textualism requires pragmatics.

“Pragmatics and …

Simulating Chill: Exploring The Cognitive And Therapeutic Potential Of Cold Vr Environments, Jessica Turner, Piper Hutson, James Hutson

Faculty Scholarship

This study investigates the cognitive and therapeutic potential of immersive virtual reality (VR) environments designed to simulate cold conditions. Through the engagement of participants through multisensory stimuli—including vivid visual representations of the Athabasca Glacier, auditory effects of icy winds, and corresponding haptic feedback—the research evaluates neurological and physiological responses associated with attention, emotional regulation, and stress modulation. Participants experienced virtual scenarios featuring icy winds and snow, activating specific neurological pathways involving the occipital lobe, primary visual cortex, superior colliculus, and insula, thus reinforcing sensory integration. Through predictive coding, the anterior insula and hypothalamus were engaged, prompting thermoregulatory simulations and subconscious …

1785 Parisian Salon Project: New Methods And Practical Innovations In Digital Heritage Reconstruction, James Hutson, Charles O'Brien, Wesley Wolfe, Kayla Kraff, Trent Olsen

Faculty Scholarship

The 1785 Salon Unreal Engine Reconstruction Project represents a significant advance in digital heritage and immersive art historical research by combining generative AI-based asset creation, modular user experience (UX) design, and historically informed workflows. During the Spring 2025 phase, the project achieved major milestones, including the successful development of a replicable pipeline for transforming 2D reference images into period-accurate 3D sculpture models using generative AI and digital sculpting tools. Simultaneously, a robust and adaptable Inspection System was engineered within Unreal Engine, offering granular interaction controls, bilingual (English/French) content integration, dynamic metadata display, and enhanced accessibility. These innovations collectively enabled historically …

Trade Integration, Petros C. Mavroidis

Faculty Scholarship

Accounts concerning the world trading system usually start the debate from the negotiation of the GATT. Trade integration before the First World War, though, had been quite remarkable, and the study of this era enriches our understanding of modern institutions in at least two ways. First, a number of GATT provisions had already been shaped during discussions following the advent of the League of Nations. Second, trade integration before the First World War did not manage to put a brake on belligerent behaviour, putting to rest the old Montesquieuan idea of doux commerce. Recent developments (like the invasion of …

Administrative Law And The Pandemic, Gillian E. Metzger

Faculty Scholarship

American administrative law’s relationship to change is, as they say, compli­cated. On the one hand, continual evolution has been an endemic feature of American administrative law. Doctrines such as Chevron deference to agency statutory interpretations were born, grew, and declined in just the period from the 1980s to today. On the other, the United States (US) Supreme Court regularly rejects such common law development in administrative law as illegitimate and insists that federal judges must adhere to the original terms of the 1946 Administrative Procedure Act (APA) and other statutes, unless the Constitution requires otherwise. And to this day scholars …

The Right To Grow Old, Jamal Greene

Faculty Scholarship

This chapter considers the status of a constitutional “right to grow old” under the US Constitution. Understood as a “positive” right – ensuring a certain minimum quality of life to people as they face the challenges of aging – such a right may seem unavailing given the austerity in respect to such rights that many lawyers associate with the US constitutional tradition. This chapter shows this view to be premature, at least. Unlike the kinds of positive rights overtly rejected in prior cases, such as rights to certain forms of social welfare or to racial equality, a right to grow …

Trump Attacks On Climate Science May Violate Numerous Federal Laws, Michael B. Gerrard

Faculty Scholarship

Starting on its first day on January 20, 2025, the second Trump administration has launched an unprecedented rollback of efforts to fight climate change. The Sabin Center for Climate Change Law’s Climate Backtracker already has 117 items.

Much of this is aimed at scientific research on climate change, or has the effect of inhibiting the conduct and dissemination of this research. Many of these actions may also violate federal laws.

This article discusses these actions, some of their legal implications, and the litigation challenges that have already been brought. It begins with actions that are specifically aimed at climate research, …

Do Bans On Conversion Therapy Impose A Governmental "Orthodoxy" About Sex And Gender?, Linda C. Mcclain

Faculty Scholarship

In Part I, this Essay evaluates how orthodoxy arguments featured in Mr. Tingley’s challenge to Washington’s ban on conversion therapy. Part II offers a preliminary analysis of Chiles v. Salazar, ⁴² which the Court will hear during its 2025-2026 Term. I illustrate how the arguments made against Washington’s law by Chiles and her amici draw from the anti-orthodoxy and marketplace of ideas rhetoric found not only in Justice Thomas’s Tingley dissent and his NIFLA opinion but also in Justice Gorsuch’s majority opinion in the 303 Creative decision.⁴³ Woven together with these speech arguments are appeals to the Court’s …

Antiracist Expert Evidence, Jasmine Gonzales Rose, Asees Bhasin, Spencer Piston

Faculty Scholarship

Since 2020, when mass protests against racism swept across the United States, scholars, lawyers, and the general public have become increasingly aware that racism permeates society and the criminal legal system, from overt racial animus to the nuanced effects of structural racism. Demonstrating the influence of racism is therefore vital to the practice of criminal defense, yet many attorneys do not know how to prove racism in court. We surveyed over seven hundred criminal-defense attorneys across the United States, and nearly half had never heard of expert witnesses testifying or submitting written reports on racism—what we call “antiracist expert evidence.” …

Neuroarts And Neuroaesthetics, James Hutson, Piper Hutson

Faculty Scholarship

Recent advancements in neuroarts and neuroaesthetics have elucidated the relationship between artistic engagement and neural processes, emphasizing the impact of aesthetic experiences on cognitive and emotional well-being. Central to this exploration is the NeuroArts Blueprint initiative, which consolidates interdisciplinary research to better understand the impactful role of the arts on brain function and health outcomes. Empirical studies highlight how exposure to art, such as music or visual stimuli, activates neural circuits involved in emotion regulation, memory, and reward processing, particularly engaging the medial orbitofrontal cortex. Innovations such as haptic and electro-tactile devices have introduced novel sensory modalities that not only …

Non-Finite Clause Use In Disciplinary Research Writing: A Formulaic Sequence-Based Functional Comparison Between Expert And Student Writers, Xixin Qiu

Faculty Scholarship

Non-finite clauses (NFCs), despite their increasingly recognized role in second language (L2) acquisition and academic writing as part of a multidimensional conceptualization of syntactic complexity, have not been analyzed in functional and discipline-specific perspectives. This study addresses this gap by providing a linguistic-descriptive account of NFC use in expert and advanced student English research writing. Using a 2.26-million-word corpus of published research articles and student manuscripts in Agricultural Science, this study profiles the distribution of NFC subtypes and identifies frequent discoursal functions realized by non-finite verb-centered formulaic sequences. The findings reveal significant differences in NFC use across writer groups, with …

Capturing Interfacial Phase Change And Flow Physics During Vertical Downflow Condensation, Thanh Hoang Phan, Cho Ning Huang, Chirag R. Kharangate

Faculty Scholarship

Two-phase configurations can address the urgent demand for effective heat dissipation solutions in Naval power and energy systems. A better understanding of thermal transport processes in phase-change flows is critical for developing novel two-phase design tools for naval scientists and engineers. This study investigates interfacial phase change and flow dynamics during condensation flow through numerical simulations. An enhanced phase change model, incorporating a mass transfer intensity coefficient dependent on condensation film thickness, is implemented for vertical downflow condensation. A two-dimensional homogeneous two-phase Reynolds-Averaged Navier-Stokes model, coupled with the Shear-Stress Transport k-ω turbulence model, is employed. The developed solver is thoroughly …

Politics And Collection Development: Behaviors In Library Collecting Based On Political Climates, Zachary G. Stein, Lindsey M. Reno

Faculty Scholarship

Over the last several years libraries in the United States have dealt with an increasing number of book challenges and calls for censorship of materials. The challenges and calls for censorship are no longer only from library patrons, but now include national organizations and even local and state legislators. Some of these actions have moved to criminalize librarians and curtail first amendment rights. Due to this new climate, it is important to examine the effect these culture wars have on library collection development decisions. This quantitative study seeks to answer that question with a nationwide survey of library professionals.

Recruitment And Retention Challenges In Southeastern Us Academic Libraries, Christopher Stewart, J.B. Hill, Louise L. Lowe, Jenna Eastwood Hill

Faculty Scholarship

Purpose – The purpose of this study is to identify challenges to recruitment and retention in academic libraries in the southeastern United States and to identify possible solutions that can be shared with other academic library recruiters.

Design/methodology/approach – This study reports on a survey of academic library administrators that investigated the challenges to recruitment and retention in academic libraries in the southeastern United Statesafter the pandemic.

Findings – The study demonstrates that elements of the workplace, such as compensation, diversity efforts, work arrangement accommodations and external factors, impact recruitment and retention. Originality/value – This study broadens the current research …

Characterization Of The Gut Microbiome In Alzheimer Disease And Mild Cognitive Impairment Among Older Adults In Uganda: A Case-Control Study, Martha Sajatovic, Scott M. Williams

Faculty Scholarship

Alzheimer disease (AD) is associated with significant shifts in the gut microbiome and is characterized by reduced microbial diversity and changes in the abundance of specific taxa. These alterations can disrupt the gut-brain axis, leading to increased intestinal permeability ("leaky gut"), systemic inflammation, and oxidative stress. Such microbial changes are thought to contribute to neurodegenerative changes, as observed in AD and cognitive decline, thus emphasizing the role of the microbiome in aging-related neurological health. Our study in urban and rural population in Uganda recruited 104 participants aged 60 years and older, categorized into AD, mild cognitive impairment (MCI), and control …

Consensus Recommendations Regarding Local And Metastasis-Directed Therapies In The Management Of Relapsed/Recurrent Ewing Sarcoma, Shauna R. Campbell, Erin Murphy, Matteo Trucco Pediatrics

Faculty Scholarship

Limited randomized or prospective data are available to guide local/metastasis directed therapy (LMDT) in relapsed/recurrent Ewing sarcoma (RR-ES), resulting in uncertainty regarding best clinical practice for these patients. This report reviews the available literature on LMDT approaches and provides consensus recommendations regarding therapeutic decision making, timing, and indications for the use of LMDT in the management of RR-ES. LMDT should be considered on a case-by-case basis to assess appropriateness, optimal timing/modality, palliative versus curative intent, and its role in relation to chemotherapy. One commonly used LMDT is radiotherapy (RT), which can be delivered through standard, hypofractionated, or stereotactic techniques based …

Materials Data Science Ontology(Mds-Onto): Unifying Domain Knowledge In Materials And Applied Data Science, Balashanmuga Priyan Rajamohan, Alexander C. Harding Bradley, Van D. Tran, Jonathan E. Gordon, Hayden W. Caldwell, Redad Mehdi, Gabriel Ponon, Quynh D. Tran, Ozan Dernek, Benjamin G. Pierce, Raymond Wieser, Weiqi Yue, Kiefer Lin, Jiana Kambo, Arafath Nihar, Pawan K. Tripathi, Yinghui Wu, Laura S. Bruckman, Erika I. Barcelos, Roger H. French

Faculty Scholarship

Ontologies have gained popularity in the scientific community as a way to standardize terminologies in organizations’ data. Although certain cohorts have created frameworks with rules and guidelines on creating ontologies, there exist significant variations in how Materials Science ontologies are currently developed. We seek to provide guidance in the form of a unified automated framework for developing interoperable and modular ontologies for Materials Data Science that simplifies the ontology terms matching by establishing a semantic bridge up to the Basic Formal Ontology(BFO). This framework provides key recommendations on how ontologies should be positioned within the semantic web, what knowledge representation …

Ai & Xr Explorations To Support Social Interactions: Speculative Design For Ubiquitous Workplace Space By And For Neurodivergent Employees, Dominique Michaud, Alejandro Reyes, Jonathan Proulx Guimond, Fafadzi Akpene Agbe, Valérie Payen, Diane Gabrielle Tremblay, Marie Claude Leblanc, Claude Vincent, Geoffreyjen Edwards, Caroline Brassard, Marie Helene Parizeau, Valéry Psyche, Martin Caouette, James Hutson, Piper Hutson, Julie Ruel, Julien Voisin, Jocelyne Kiss

Faculty Scholarship

This study explores the potential of interdisciplinary theories and advanced technologies, such as augmented realities and artificial intelligence, to address the socio-professional integration challenges faced by neurodivergent individuals, particularly those on the autism spectrum. It investigates the design of personalized, functional spaces that integrate interconnected living environments and intelligent systems tailored to support communication needs. Using speculative design methodology, the research adopts an experiential framework to examine alternative solutions, starting with a central hypothesis and testing it through debates with researchers, experts, neurodivergent individuals, and knowledge users. The premise is rooted in the recognition that neurodivergent individuals encounter significant barriers …

Integrating Ai-Driven Neurofeedback With Brain-Computer Interfaces: A Paradigm For Effortless Learning And Workforce Transformation, James Hutson

Faculty Scholarship

This editorial discusses the merging of AI-driven neurofeedback with brain-computer interfaces (BCIs) to create a new model for effortless, unconscious learning. By interpreting and reinforcing specific neural patterns, these technologies can enable users to acquire skills without traditional instruction, making them especially valuable in fast-evolving industries. They also offer powerful tools for individuals with physical impairments by enabling control through thought alone. However, the author emphasizes the importance of ethical oversight, particularly around cognitive autonomy, data privacy, and consent. As the field matures, ongoing research and regulation will be essential to ensure responsible development and widespread, beneficial use.

The Fear Of Replacement: How Ai Panic In Journalism Mirrors Existential Crisis In Industry, James Hutson

Faculty Scholarship

This study systematically examines the portrayal of artificial intelligence (AI) errors, such as hallucinations and deepfakes, in journalistic contexts, evaluating whether these narratives reflect a broader existential anxiety about AI's role in reshaping journalism. Using a systematic literature review combined with a qualitative content analysis of recent AI-focused news reports, this study identifies recurring themes in media coverage to assess the accuracy and context of reported AI errors relative to actual technological limitations and affordances. Findings suggest that while AI errors are comparatively rare, they receive amplified coverage, often fueling public mistrust in AI technologies. Nevertheless, a balanced examination reveals …

Dictating The Divine: Revisiting Authorship, Intention, And Authority From Sacred Texts To Generative Ai, James Hutson, W. Travis Mcmaken

Faculty Scholarship

This article interrogates the historical practice of mediated authorship in religious texts to draw critical parallels with contemporary debates surrounding generative artificial intelligence (AI), specifically large language models (LLMs). By juxtaposing the mediated authorship of sacred texts, such as the Hebrew Bible and New Testament—where figures like the Apostle Paul dictated theological concepts to scribes who infused these directives with their interpretive insights—with the generative processes of LLMs, this research underscores the shared dynamics of co-constructed authorship across historical and technological contexts. Employing interdisciplinary methodologies from art history, textual studies, and reception theory, as well as theological and biblical studies, …