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Articles 181 - 210 of 8074
Full-Text Articles in Entire DC Network
Designing For Complementarity: Skills, Work, And Education In The Age Of Ai — A Review, James Hutson
Designing For Complementarity: Skills, Work, And Education In The Age Of Ai — A Review, James Hutson
Faculty Scholarship
This review synthesizes 2023–2025 evidence on how generative AI and automation are reconfiguring role structures, skill demands, and entry pathways, and proposes design principles that shift attention from task substitution to role redesign and talent architecture. Theoretical framework: Drawing on task-based labor economics, socio-technical systems design, and humancapital complementarity, the review distinguishes domains where substitution pressures concentrate from those where augmentation dominates. Method: A narrative review of peerreviewed studies, official statistics, and policy/industry reports prioritized empirically grounded findings on employment effects, skills, governance, and program outcomes; inclusion emphasized methodological transparency and recency. Results and discussion: Convergent evidence shows contraction in …
Quilting As Reproductive Justice Information Activism, Liz Chenevey
Quilting As Reproductive Justice Information Activism, Liz Chenevey
Faculty Scholarship
No abstract provided.
Joinder, Not Jurisdiction: Toward A New Theory Of Standing, Adam N. Steinman
Joinder, Not Jurisdiction: Toward A New Theory Of Standing, Adam N. Steinman
Faculty Scholarship
This Article builds on an important development in the Supreme Court’s standing jurisprudence to propose a novel theory that would allow more meaningful access to federal courts while vindicating legitimate separation-of-powers concerns. In its recent decision in TransUnion LLC v. Ramirez, the Supreme Court endorsed a theory of standing based on Article II, writing that litigation between private parties—even when explicitly authorized by Congress—can run afoul of the executive branch’s interest in “how to prioritize and how aggressively to pursue legal actions against defendants who violate the law.” This Article II move has been justifiably criticized. But it is …
Empirical Methods In Contract Law, Monika Leszczynska
Empirical Methods In Contract Law, Monika Leszczynska
Faculty Scholarship
Researchers employ various empirical methods to provide insights into contractual legal issues. For instance, systematic content analysis has been used to examine the terms of contracts or court judgments in contractual disputes. This approach, though different from doctrinal methods, enhances our understanding of legal content. Surveys and experimental methods, on the other hand, provide evidence on people's perceptions of contract terms or contractual behavior such as consent, misrepresentation, or breach. The findings from these studies inform contract law theories, which are based on assumptions about behavior in contractual relationships. Empirical studies also strengthen arguments in normative research by providing evidence …
From Displacement To Design: Reframing Work, Skills, And Education For The Ai-Transformed Economy A Review, James Hutson
From Displacement To Design: Reframing Work, Skills, And Education For The Ai-Transformed Economy A Review, James Hutson
Faculty Scholarship
Between 2023 and 2025, the U.S. labor market entered a period of accelerated restructuring driven by generative artificial intelligence (AI) and automation. Routine, entry-level cognitive roles—particularly in clerical, customer service, and junior technical positions—contracted sharply as intelligent systems assumed high-volume, rules-based tasks. While these displacements echo past automation cycles, the present transformation is distinct in its scope, affecting both knowledge work and creative functions, and in its speed, amplified by enterprise-scale adoption. Simultaneously, demand has surged for specialized AI-related positions, interdisciplinary roles blending domain expertise with AI fluency, and ―durable skills‖ that remain resistant to automation. Drawing on labor market …
Most-Favored-Nation's False Promises, George A. Bermann
Most-Favored-Nation's False Promises, George A. Bermann
Faculty Scholarship
Most-favoured-nation (MFN) protection seems decidedly straightforward both in meaning and operation, certainly as compared to other investment protections, such as fair and equitable treatment, which are plagued with indeterminacy. But the clarity of meaning and ease of application of MFN clauses are largely illusory. An examination of arbitral case law reveals seriously underestimated uncertainties surrounding the doctrine’s scope and workings. But the problems with MFN run far deeper. MFN may have the virtue of enhancing the level of protection of foreign investments. But States do not only extend benefits; they also withhold them. MFN disrespects the balance that States sought …
Algorithmic Governance And The Boardroom: Empirical And Strategic Perspectives On Ai Integration In Corporate And Educational Oversight, James Hutson, Guarango Banerjee
Algorithmic Governance And The Boardroom: Empirical And Strategic Perspectives On Ai Integration In Corporate And Educational Oversight, James Hutson, Guarango Banerjee
Faculty Scholarship
The accelerating digitization of executive decision-making has prompted critical re-examination of the function and value of traditional boards of directors within corporate and educational institutions. Empirical research consistently reveals that human boards, while ostensibly tasked with strategic insight and fiduciary oversight, are frequently constrained by structural inefficiencies—such as director overcommitment, inflated compensation, and persistent conflicts of interest—that undermine organizational performance. Against this backdrop, the integration of Artificial Intelligence agents, either as analytic adjuncts or autonomous decision-makers, emerges as a plausible avenue for enhancing board effectiveness. This article synthesizes global case studies, peer-reviewed findings, and real-time technological developments to critically evaluate …
Harnessing The Electronic Health Record To Identify And Enroll People With Epilepsy Into A Self-Management Program: Implementation And Scalability In A Clinical Setting, Clara Adeniyi, Richard Barigye, Jessica Black, Nicole Fiorelli, Carrie Rogers, Martha Sajatovic
Harnessing The Electronic Health Record To Identify And Enroll People With Epilepsy Into A Self-Management Program: Implementation And Scalability In A Clinical Setting, Clara Adeniyi, Richard Barigye, Jessica Black, Nicole Fiorelli, Carrie Rogers, Martha Sajatovic
Faculty Scholarship
Rationale: “Self-management for people with epilepsy and a history of negative health events” (SMART) is an 8-week, remotely delivered, Epilepsy Self-Management (ESM) program. The ongoing EXPANDing self-management support in healthcare networks (EXPAND) initiative leveraged the Electronic Health Record (EHR) to identify SMART candidates, simplify recruitment, and reduce staff workload. Methods: This is an ongoing implementation effort at two Level 4 Epilepsy Centers (Iowa and Cincinnati) using the Epic EHR which follows 9326 People With Epilepsy (PWE). The EHR uses pre-visit screening to identify PWE with a recent seizure; barriers to medication adherence; depression symptoms; age 18–25; or residence in rural …
Social Cognition As A Mediator Between Neurocognition And Functional Outcome In Early Course Schizophrenia, Anju Kotwani, Jessica A. Wojtalik, Douglas D. Gunzler, Wilson J. Brown, Rochanne L. Honarvar, Martha Sajatovic
Social Cognition As A Mediator Between Neurocognition And Functional Outcome In Early Course Schizophrenia, Anju Kotwani, Jessica A. Wojtalik, Douglas D. Gunzler, Wilson J. Brown, Rochanne L. Honarvar, Martha Sajatovic
Faculty Scholarship
Social cognition is an established mediator between neurocognition and functional outcome in schizophrenia, but there is limited evidence for this model specifically in the early course, which is a critical window for intervention to reduce long-term disability. This study aimed to test the social cognition mediator model in the early course of schizophrenia and identify social cognitive subdomains that may have stronger indirect effects on the relationship between neurocognition and functional outcome. This secondary analysis utilized baseline cognitive and functional outcome data from a cognitive remediation trial for outpatients with early course schizophrenia (N = 102). A path analysis approach …
Social Cognition As A Mediator Between Neurocognition And Functional Outcome In Early Course Schizophrenia, Anju Kotwani, Jessica A. Wojtalik, Douglas D. Gunzler, Wilson J. Brown, Rochanne L. Honarvar, Martha Sajatovic
Social Cognition As A Mediator Between Neurocognition And Functional Outcome In Early Course Schizophrenia, Anju Kotwani, Jessica A. Wojtalik, Douglas D. Gunzler, Wilson J. Brown, Rochanne L. Honarvar, Martha Sajatovic
Faculty Scholarship
Social cognition is an established mediator between neurocognition and functional outcome in schizophrenia, but there is limited evidence for this model specifically in the early course, which is a critical window for intervention to reduce long-term disability. This study aimed to test the social cognition mediator model in the early course of schizophrenia and identify social cognitive subdomains that may have stronger indirect effects on the relationship between neurocognition and functional outcome. This secondary analysis utilized baseline cognitive and functional outcome data from a cognitive remediation trial for outpatients with early course schizophrenia (N = 102). A path analysis approach …
Academic Research And (Google Or Reddit): A Librarian-Faculty Collaboration To Improve Student Source Engagement, Stephanie Redekop, Olivia Hobbs
Academic Research And (Google Or Reddit): A Librarian-Faculty Collaboration To Improve Student Source Engagement, Stephanie Redekop, Olivia Hobbs
Faculty Scholarship
Effective source use is a critical skill for first-year writing students because it prepares them for academic, professional, and civic engagement; however, existing research demonstrates that selecting appropriate sources and engaging them insightfully remains a significant challenge. While students struggle with the combined pressures to read, evaluate, and synthesize scholarly sources, we argue that online media including news articles, opinion pieces, and social media posts are a potent but underutilized resource for building students’ competence and confidence with source use. In this article, we present the methods that we have collaboratively developed as an instruction librarian and a first-year writing …
Stakeholder Views On Lessons Learned For The Antimicrobial Resistance Panel From Previous International Science Panels [Version 1], Iruka N. Okeke, Ayodele A. Akinyele, Javier Guzman, Kevin Outterson
Stakeholder Views On Lessons Learned For The Antimicrobial Resistance Panel From Previous International Science Panels [Version 1], Iruka N. Okeke, Ayodele A. Akinyele, Javier Guzman, Kevin Outterson
Faculty Scholarship
The United Nations General Assembly called in September 2024 for the establishment of an independent panel for actionable evidence against antimicrobial resistance (IPEA). The task of designing the panel was given to the Quadripartite Joint Secretariat (QJS) on Antimicrobial Resistance (AMR) with a delivery timeline of 15 months. To promote stakeholder thought and input around what this panel should look like and how it should work, which could feed into the QJS’s consultation process, we independently commissioned seven papers to examine lessons that could be learned from other high-level scientific panels. We then called a convening of stakeholders that were …
Organizing For Abolition In Ice Custody, Sarah R. Sherman-Stokes
Organizing For Abolition In Ice Custody, Sarah R. Sherman-Stokes
Faculty Scholarship
The final Immigration and Customs Enforcement (“ICE”) detainees were released from the Irwin County Detention Center in early September 2021.2 A court did not order the end of ICE detention at Irwin. A social movement, led by people detained at Irwin, had a pronounced impact on the epistemological landscape and changed both normative principles and public opinion.3 Those detained at Irwin organized and acted to create new understanding of law and protect their rights in ways that courts and legislatures could not. This Essay tells the story of that demosprudential project; a dialectic between legal elites and people …
College Students' Perceptions Of Artificial Intelligence (Ai) Risks And Benefits In Pakistan, Rauf Arif, Muhammad Ittefaq, Lamia Zia
College Students' Perceptions Of Artificial Intelligence (Ai) Risks And Benefits In Pakistan, Rauf Arif, Muhammad Ittefaq, Lamia Zia
Faculty Scholarship
With the rapid advancements in technology over the past 2 decades, it has become crucial to understand people’s attitudes toward artificial intelligence (AI) adoption and its associated risks. Given the increasing access to the AI technologies, it is imperative to examine how young people in non-Western societies like Pakistan perceive AI risks and benefits. We conducted an online survey of college students who had used AI technology in the past 6 months. The results of our study indicate that the majority of college students view AI technology positively and perceive it as an opportunity to enhance workplace productivity. In addition, …
Automated Raft Polymerization Using Batch, Increment, And Continuous Addition Modes To Enhance Properties Of Fluorescent Polymers, Sophia Beilharz, Konpal Raheja, Metin Karayilan
Automated Raft Polymerization Using Batch, Increment, And Continuous Addition Modes To Enhance Properties Of Fluorescent Polymers, Sophia Beilharz, Konpal Raheja, Metin Karayilan
Faculty Scholarship
We report an automated RAFT copolymerization strategy using a Chemspeed robotic platform capable of executing batch, incremental, and continuous monomer addition workflows under inert conditions. Copolymerizations of oligo(ethylene glycol) acrylate with fluorescein o-acrylate were performed in different solvents with reaction kinetics monitored via time-resolved1 H NMR spectroscopy. Continuous addition reactions conducted at rates from 0.3 to 1.0 mL/hr enabled compositional tuning and control over monomer sequence. This automated workflow has a potential to provide a high-throughput platform for polymer design, kinetic profiling, and material property optimization with minimal manual intervention.
A 6-Month, Prospective Randomized Controlled Trial Of The Targeted Management (Team) Intervention Vs. Enhanced Treatment As Usual Among Ugandans At Risk For Stroke, Carla Conroy, Joy Yala, Christopher J. Burant, Shirley Moore, Martha Sajatovic
A 6-Month, Prospective Randomized Controlled Trial Of The Targeted Management (Team) Intervention Vs. Enhanced Treatment As Usual Among Ugandans At Risk For Stroke, Carla Conroy, Joy Yala, Christopher J. Burant, Shirley Moore, Martha Sajatovic
Faculty Scholarship
Background Among low and middle-income countries, especially in Sub-Saharan Africa, the stroke burden is severe, with increasing trends in stroke incidence, prevalence, and mortality. Aims This 6-month, prospective randomized controlled trial (RCT) compared a novel stroke risk reduction approach (TargetEd manAgeMent Intervention (TEAM)) vs. Enhanced Treatment as Usual (ETAU) in 247 Ugandans at risk for stroke. Methods Participants, enrolled across 3 Ugandan sites, were adults with high stroke risk. The primary outcome was a change in systolic blood pressure (SBP) from baseline to 6-month follow-up. Secondary outcomes included changes from baseline to 6 months on diastolic BP (DBP), serum lipids, …
Planetary Health: At The Crossroads Of Cvd Prevention, Tasveer Khawaja, Sanjay Rajagopalan
Planetary Health: At The Crossroads Of Cvd Prevention, Tasveer Khawaja, Sanjay Rajagopalan
Faculty Scholarship
Purpose of Review: To highlight important recent findings demonstrating the interconnectedness of planetary and human health with a focus on cardiovascular disease. Recent Findings: Data continue to demonstrate a clear interconnectedness between the health of the planet and human health, with cardiovascular disease as an important outcome. The central roles of air pollution, non-optimal temperatures, water/waste management, and food/biodiversity are highlighted. We also highlight the clear opportunity for healthcare organizations to facilitate change that will yield positive environmental and patient outcomes. Summary: The undeniable interconnectedness of the health of the planet and human health serves as a call to action …
Integrating Neuroaesthetic Design Into Brain-On-Chip Research: Toward Enhanced Neural Engagement And Cognitive Accessibility, Piper Hutson, James Hutson
Integrating Neuroaesthetic Design Into Brain-On-Chip Research: Toward Enhanced Neural Engagement And Cognitive Accessibility, Piper Hutson, James Hutson
Faculty Scholarship
This study examines the potential for neuroaesthetic design and adaptive neurofeedback principles to enhance brain-on-chip (BoC) research, with an emphasis on optimizing neural engagement and cognitive accessibility for diverse populations. Existing BoC platforms have transformed neuroscience through high-fidelity modeling of neural circuits, yet cognitive accessibility and sensory inclusion remain comparatively underexplored. Drawing upon recent studies in neuroinclusion, multisensory interface design, and adaptive feedback, this work synthesizes findings from biophilic interface architecture, neurofeedback literature, and embodied cognition frameworks. The manuscript outlines a multidisciplinary research agenda that prioritizes sensory diversity and ethical considerations in the evolution of BoC systems. Instead of making …
Increasing The Feasibility, Impact, And Equity Of The Medicare Annual Wellness Visit (Awv) With A Practice Tailored Awv Intervention: A Stepped Wedge Clinical Trial Protocol, Chi-Hong Tseng, Neil S. Wenger
Increasing The Feasibility, Impact, And Equity Of The Medicare Annual Wellness Visit (Awv) With A Practice Tailored Awv Intervention: A Stepped Wedge Clinical Trial Protocol, Chi-Hong Tseng, Neil S. Wenger
Faculty Scholarship
Background Older adults vastly underutilize evidence-based preventive health services and screenings that reduce illness, morbidity and mortality. The free-to-patient Medicare Annual Wellness Visit (AWV) is an opportunity to enhance preventive healthcare use, but also is underused. Objectives To evaluate the effect of a practice-tailored intervention on the sustained use of Medicare AWVs and on guideline-recommended preventive services and racial/ethnic disparities in 3 types of practice settings. Methods This is a stepped wedge cluster randomized controlled trial. The intervention will be implemented at the practice level in 24 primary care practices across the country (8 community-based, 8 academic, and 8 serving …
Mitigating Ai Bias With Prompt Augmentation, Verónica C. Gonzales
Mitigating Ai Bias With Prompt Augmentation, Verónica C. Gonzales
Faculty Scholarship
Large-language-model (“LLM”) outputs are inevitably shaped by assumptions, biases, and attitudes rooted in racism and other systemic inequities embedded in the civil-law tradition. This Equity-in-Justice CLE focuses on helping civil legal service providers recognize and work to eliminate biases in generative AI outputs through equity-centered prompt augmentation and engineering. These small, cost-free interventions re-orient LLMs assistance toward fairness, cultural competency, and client-centered outcomes. Participants leave with an action plan for embedding anti-bias safeguards in everyday research, drafting, and client communication tasks.
Cultivating Identity, Workforce Readiness, And Heutagogical Lifelong Learning: The Case For Student-Trained Ai Agents In Postsecondary Education, James Hutson
Faculty Scholarship
The accelerated integration of human-centered artificial intelligence and human-computer intelligent interaction (HCII) into postsecondary education has inaugurated a paradigm shift in how learners develop cognitive, socio emotional, and professional competencies. This article argues that requiring students to iteratively build and refine custom AI agents—digital “clones” or GPTs trained on their evolving beliefs, knowledge, values, and interests addresses three pressing challenges facing contemporary higher education. First, the process of self-modeling via agent training compels deep self-reflection, fostering socio-economic development and identity formation during the critical neurodevelopmental period that extends into the mid-twenties. Second, as industry trends increasingly prioritize the creation of …
Integrating Art Therapy And Emerging Technologies For Enhanced Neuroplasticity And Ptsd Intervention, Piper Hutson, James Hutson
Integrating Art Therapy And Emerging Technologies For Enhanced Neuroplasticity And Ptsd Intervention, Piper Hutson, James Hutson
Faculty Scholarship
Post-traumatic stress disorder (PTSD) remains resistant to many conventional treatments, underscoring the need for integrative approaches that harness neuroplasticity. Art therapy, with its capacity to facilitate nonverbal trauma processing and multisensory engagement, has shown distinctive advantages over verbal and pharmacological interventions. Recent innovations, including virtual reality (VR), artificial intelligence (AI), and biofeedback have amplified the therapeutic efficacy of art-based interventions by enabling adaptive, real-time modulation of emotional and physiological states. This review synthesizes current research on technologically enhanced art therapy, comparing it to established treatments such as cognitive behavioral therapy (CBT) and eye movement desensitization and reprocessing (EMDR). Findings indicate …
Fixing A 100-Year-Old Mistake, Michael J. Graetz
Fixing A 100-Year-Old Mistake, Michael J. Graetz
Faculty Scholarship
Posing the question of international tax cooperation versus competition reminds me of multiple-choice exams in which the right answer is “all of the above.” National interests determine which dominates at any given time. And in tax competition among nations, zero is not a lower bound.
In 1918, to encourage U.S. investments abroad, the United States enacted a credit for foreign taxes paid by U.S. companies and relinquished taxing rights to most foreign-source income. With the foreign tax credit, the United States assumed sole responsibility for reducing the double taxation of its residents and citizens. As the influential economist Edwin Seligman …
Caste Formalism: The Law And Politics Of Equality In India, Madhav Khosla, Pratap Bhanu Mehta
Caste Formalism: The Law And Politics Of Equality In India, Madhav Khosla, Pratap Bhanu Mehta
Faculty Scholarship
In modern constitutional democracies, achieving equality has long been a challenge. In recent years, theorists have focused on understanding the meaning of discrimination and determining when and how discrimination becomes problematic. One critical issue that has long animated discussions on both the general guarantee of equality and the specific goals of anti-discrimination law is the relationship between individuals and groups. If a constitutional order aims to take equality seriously, how should it address the experiences of specific groups historically subjected to discrimination? Indeed, questions of equality and discrimination often converge around the issue of affirmative action, sometimes at the expense …
Too Many Mergers? The Golden Parachute As A Driver Of M&A Activity In The 21st Century, Jeffrey N. Gordon
Too Many Mergers? The Golden Parachute As A Driver Of M&A Activity In The 21st Century, Jeffrey N. Gordon
Faculty Scholarship
This Article argues that the corporate governance regime in the United States has produced a level of mergers and acquisition activity greater than the social optimum because of the current version of the “golden parachute,” a super-bonus payoff to a target CEO. In the late nineteenth through the twentieth century, M&A activity was characterized by “waves” that reflected adaptations to changing external environment, whether the efficient production frontier, regulatory constraints, or capital market developments. Economically-motivated parties saw the opportunities in changing the boundaries of the firm; successful first-movers spawned imitators, hence a wave, which eventually subsided, often alongside deteriorating capital …
Teaching Transactional Skills And Lawyering Values To First-Year Students Through An Affordable-Housing Deal, Laura E. D'Amato
Teaching Transactional Skills And Lawyering Values To First-Year Students Through An Affordable-Housing Deal, Laura E. D'Amato
Faculty Scholarship
With the anticipated launch of the NextGen bar exam next year, transactional lawyering skills are enjoying increased attention in first-year law school curricular development. At the same time, recent amendments to ABA Rule 303 have made it essential for new law students to learn about the profession’s core values and responsibilities. While these evolving priorities open the door to pedagogical innovation, incorporating two distinct topics into an already packed curriculum can be challenging. This article explores how a simulated affordable-housing financing deal has served as a cohesive foundation for introducing first-year students to transactional skills and core professional values.
Family Caregivers’ Perceptions Of Quality Of Dementia Self-Care In Wakiso District, Uganda, Martha Sajatovic, Kylie Meyer
Family Caregivers’ Perceptions Of Quality Of Dementia Self-Care In Wakiso District, Uganda, Martha Sajatovic, Kylie Meyer
Faculty Scholarship
INTRODUCTION: In Sub-Saharan Africa, most people with dementia are cared for in the home setting (dementia self-care) with hardly any support from the formal health and social care system. The study explored family caregivers' perceptions of quality of dementia self-care. METHODS: A descriptive-exploratory qualitative study design was used. Data were collected through four focus group discussions with 48 family caregivers of older people with dementia, recruited from four villages of the Wakiso district in Uganda. RESULTS: Five themes emerged: (1) patience and understanding; (2) maintaining hygiene and cleanliness; (3) constant supervision and safety precautions; (4) personalized care by understanding individual …
State-Level Immigrant Policies And Diabetes Prevalence In Latino And Asian American Groups: A Weighted Multilevel Analysis, Md Towfiqul Alam, Jennifer Toller Erausquin, Erica Payton, Elizabeth Vásquez, Sandra Echeverria
State-Level Immigrant Policies And Diabetes Prevalence In Latino And Asian American Groups: A Weighted Multilevel Analysis, Md Towfiqul Alam, Jennifer Toller Erausquin, Erica Payton, Elizabeth Vásquez, Sandra Echeverria
Faculty Scholarship
Introduction: Growing literature has shown that immigrant-related policies influence population health by limiting or enhancing immigrants’ rights. However, less is known about the role of state-level immigrant policies shaping chronic health conditions such as type 2 diabetes (T2DM). This cross-sectional study examined the association between state-level immigrant policies (both criminalising and inclusive) and prevalence of T2DM among individuals of Latin American and Asian American origin.
Method: We included adults aged 18+years sampled in the 2014–2018 behavioral risk factor surveillance system (BRFSS) (n=201 824), a survey design that allows the calculation of state-level estimates. Using existing policy measures, states …
Conceptualizing The Research Cycle For The Field Of Materials Science And Engineering, Jennifer L.W. Carter
Conceptualizing The Research Cycle For The Field Of Materials Science And Engineering, Jennifer L.W. Carter
Faculty Scholarship
Abstract: Early-career materials researchers often receive guidance from their individual advisors on best practices for conducting research, but the materials science community lacks an explicit model of the research process. As a result, the lived experience of an individual researcher can be quite different from their peers since they may be exposed to a different unique set of implicit research steps. In this article, we translate an existing research heuristic from other fields and make explicit the steps, methodologies, and strategies materials science engineering researchers utilize to advance our collective materials science knowledge. This newly proposed research cycle can improve …
Alpha-Synuclein Dysregulation In Systemic Pathophysiology Of Synucleinopathies, Hallie H. Dolin, Bowen Zhou, Robert W. Maitta
Alpha-Synuclein Dysregulation In Systemic Pathophysiology Of Synucleinopathies, Hallie H. Dolin, Bowen Zhou, Robert W. Maitta
Faculty Scholarship
Alpha-synuclein (α-syn) has long been identified as the etiologic agent of multiple neurodegenerative diseases, the most common and well-known of which are Parkinson's disease (PD) and Lewy body dementia (LBD). While it is known that the pathophysiology of these synucleinopathies involves aggregation of improperly-folded α-syn, the mechanisms leading to its accumulation have not been fully identified. However, multiple pathways have been proposed, any or all of which may contribute to synucleinopathies. The role of α-syn in normal homeostasis and in other organ systems, especially the hematopoietic system, has been reported recently. Research within the last decade has shown that α-syn …