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Articles 9811 - 9840 of 45867
Full-Text Articles in Entire DC Network
Using The World Café Methodology To Support Community-Centric Research And Practice In Library And Information Science, Vanessa Kitzie, Jocelyn Pettigrew, Travis L. Wagner, Nick Vera
Using The World Café Methodology To Support Community-Centric Research And Practice In Library And Information Science, Vanessa Kitzie, Jocelyn Pettigrew, Travis L. Wagner, Nick Vera
Faculty Publications
The World Café (TWC) methodology is a form of action research that develops collective knowledge among individuals and communities to address shared problems. TWC can complement LIS research and practice that is increasingly participatory and community centric. The potentials and pitfalls for TWC are illustrated by ongoing research examining public library service to LGBTQIA+ communities for health information. The authors used TWC in a community forum between LGBTQIA+ community leaders and librarians/paraprofessionals in [name removed for blind review]. Per TWC conventions, participants engaged in day-long rotating café-style table conversations that encouraged new ideas and collective dialog. Discussion centered on two …
It Starts At Home: Infusing Radical Empathy Into Graduate Education, Nicole A. Cooke, Kellee E. Warren, Molly Brown, Athena Jackson
It Starts At Home: Infusing Radical Empathy Into Graduate Education, Nicole A. Cooke, Kellee E. Warren, Molly Brown, Athena Jackson
Faculty Publications
This interview features a conversation between a library and information science educator (Cooke) and three archival and special collections professionals with varying levels of experience in the field (Warren, Brown, and Jackson). Among the goals of this frank conversation is to highlight the lived experiences of practicing archivists and educators and discuss why it is becoming increasingly important to talk about empathy, diversity, equity, and inclusion in greater context. As part of that context, we must discuss the need to continuously infuse these values into graduate education, professional development, research, writing, and peer mentoring. Espousing and implementing an ethics of …
New Transitions And Levels For Tb 163 Obtained From Β -Decay Studies, C. J. Zachary, E. Wang, N. T. Brewer, J. C. Batchelder, J. H. Hamilton, J. M. Eldridge, B. M. Musangu, A. V. Ramayya, C. J. Gross, K. P. Rykaczewski, R. Grzywacz, A. C. Dai, F. R. Xu, M. Madurga, D. Miller, D. W. Stracener, C. Jost, E. F. Zganjar, J. A. Winger, M. Karny, S. V. Paulauskas, S. H. Liu, M. Wolińska-Cichocka, S. W. Padgett, A. J. Mendez, K. Miernik, A. Fijałkowska, S. V. Ilyushkin
New Transitions And Levels For Tb 163 Obtained From Β -Decay Studies, C. J. Zachary, E. Wang, N. T. Brewer, J. C. Batchelder, J. H. Hamilton, J. M. Eldridge, B. M. Musangu, A. V. Ramayya, C. J. Gross, K. P. Rykaczewski, R. Grzywacz, A. C. Dai, F. R. Xu, M. Madurga, D. Miller, D. W. Stracener, C. Jost, E. F. Zganjar, J. A. Winger, M. Karny, S. V. Paulauskas, S. H. Liu, M. Wolińska-Cichocka, S. W. Padgett, A. J. Mendez, K. Miernik, A. Fijałkowska, S. V. Ilyushkin
Faculty Publications
Transitions in Tb163 following β decay of Gd163 were obtained as part of investigations of γ rays emitted following Eu163β decay to Gd163. Detailed analysis of the low-energy structure of Tb163 has been carried out with these data to expand previous β-decay studies and reactions studies of levels in Tb163. Data were collected at the LeRIBSS station of the Holifield Radioactive Ion Beam Facility at Oak Ridge National Laboratory with an array of four Clover HPGe detectors for γ rays and two plastic scintillators for β detection. The γ rays were identified as belonging to Gd163 and Tb163 via mass …
Preface For Article Collection "Evolution And Variability Of Asian Monsoon And Its Linkage With Cenozoic Global Cooling", Ryuji Tada, Christian Betzler, Peter D. Clift
Preface For Article Collection "Evolution And Variability Of Asian Monsoon And Its Linkage With Cenozoic Global Cooling", Ryuji Tada, Christian Betzler, Peter D. Clift
Faculty Publications
No abstract provided.
A One Dimensional Elliptic Distributed Optimal Control Problem With Pointwise Derivative Constraints, Susanne C. Brenner, Li Yeng Sung, Winnifried Wollner
A One Dimensional Elliptic Distributed Optimal Control Problem With Pointwise Derivative Constraints, Susanne C. Brenner, Li Yeng Sung, Winnifried Wollner
Faculty Publications
We consider a one dimensional elliptic distributed optimal control problem with pointwise constraints on the derivative of the state. By exploiting the variational inequality satisfied by the derivative of the optimal state, we obtain higher regularity for the optimal state under appropriate assumptions on the data. We also solve the optimal control problem as a fourth order variational inequality by a C finite element method, and present the error analysis together with numerical results. 1
Does Ecological Water Replenishment Help Prevent A Large Wetland From Further Deterioration? Results From The Zhalong Nature Reserve, China, Liwen Chen, Sixin Liu, Yanfeng Wu, Y. Jun Xu, Shengbo Chen, Shiliang Pang, Zongting Gao, Guangxin Zhang
Does Ecological Water Replenishment Help Prevent A Large Wetland From Further Deterioration? Results From The Zhalong Nature Reserve, China, Liwen Chen, Sixin Liu, Yanfeng Wu, Y. Jun Xu, Shengbo Chen, Shiliang Pang, Zongting Gao, Guangxin Zhang
Faculty Publications
Ecological water replenishment (EWR) has been increasingly applied to the restoration and maintenance of wetland hydrological conditions across China since the beginning of the 21st century. However, little is known about whether EWR projects help protect and/or restore wetland ecohydrology. As one of the earliest and longest-running EWR projects in China, water has been released from the Nenjiang River into the Zhalong wetland since 2001. It is important to examine the ecohydrological effects of this EWR project. In this study, long time series remote sensing data were used to extract the water area, inundation frequency, and normalized difference vegetation index …
Ideas And Perspectives: The Same Carbon Behaves Like Different Elements - An Insight Into Position-Specific Isotope Distributions, Yuyang He, Xiaobin Cao, Huiming Bao
Ideas And Perspectives: The Same Carbon Behaves Like Different Elements - An Insight Into Position-Specific Isotope Distributions, Yuyang He, Xiaobin Cao, Huiming Bao
Faculty Publications
It is expected that information on the source, reaction pathway, and reaction kinetics of an organic compound can be obtained from its position-specific isotope compositions or intramolecular isotope distribution (Intra-ID). To retrieve the information, we could use its predicted equilibrium Intra-ID as a reference for understanding the observed Intra-IDs. Historically, observed, apparently close-to-equilibrium carbon Intra-ID has prompted an open debate on the nature of biosystems and specifically the pervasiveness of reversible biochemical reactions. Much of the debate remains unresolved, and the discussion has not clearly distinguished between two states of equilibrium: (1) the equilibrium among the corresponding bond-breaking and bond-forming …
Instead Of The Thorn, Wilber Alexander
Superconducting Phase Transition In Inhomogeneous Chains Of Superconducting Islands, Eduard Ilin, Irina Burkova, Xiangyu Song, Michael V. Pak, Dmitri S. Golubev, Alexey Bezryadin
Superconducting Phase Transition In Inhomogeneous Chains Of Superconducting Islands, Eduard Ilin, Irina Burkova, Xiangyu Song, Michael V. Pak, Dmitri S. Golubev, Alexey Bezryadin
Faculty Publications
We study one-dimensional chains of superconducting islands with a particular emphasis on the regime in which every second island is switched into its normal state, thus forming a superconductor-insulator-normal metal (S-I-N) repetition pattern. As is known since Giaever tunneling experiments, tunneling charge transport between a superconductor and a normal metal becomes exponentially suppressed, and zero-bias resistance diverges, as the temperature is reduced and the energy gap of the superconductor grows larger than the thermal energy. Here we demonstrate that this physical phenomenon strongly impacts transport properties of inhomogeneous superconductors made of weakly coupled islands with fluctuating values of the critical …
Short-Term Intersection Traffic Flow Forecasting, Wenrui Qu, Jinhong Li, Lu Yang, Delin Li, Shasha Liu, Qun Zhao, Yi Qi
Short-Term Intersection Traffic Flow Forecasting, Wenrui Qu, Jinhong Li, Lu Yang, Delin Li, Shasha Liu, Qun Zhao, Yi Qi
Faculty Publications
The intersection is a bottleneck in an urban roadway network. As traffic demand increases, there is a growing congestion problem at urban intersections. Short-term traffic flow forecasting is crucial for advanced trip planning and traffic management. However, there are only a handful of existing models for forecasting intersection traffic flow. In addition, previous short-term traffic flow forecasting models usually were for predicting roadway conditions in a very short period, such as one minute or five minutes, which is often too late given that a driver may well be approaching the bottleneck already. Being able to accurately predict traffic congestions in …
Truly, Madly, Deeply: Adverbs And Ells, Kristin Lems
Truly, Madly, Deeply: Adverbs And Ells, Kristin Lems
Faculty Publications
In this issue’s column focusing on adverbs and English language learners, columnist Kristin Lems explores some of the basic but not-so-obvious features about adverbs that readers and writers need to learn in order to take advantage of these powerful levers of language. The odds are very good that your native English speakers will also benefit from this information—and you might learn a thing or two as well.
The State Of Research In Veterans Studies: A Systematic Literature Review, Leonard Lira, Janani Chandrasekar
The State Of Research In Veterans Studies: A Systematic Literature Review, Leonard Lira, Janani Chandrasekar
Faculty Publications
New areas of research on veterans are emerging as the field of veterans studies develops and grows. Yet gaps remain in interdisciplinary research efforts on veterans. The research available across disciplines is still too fragmented to coalesce into a full-fledged field of veteran studies, as other categorical, area, and identity fields of study have done so. By surveying research literature of multiple disciplines used in the curricula of higher education-level veteran study programs, this article presents a thematic and integrative review of the state of research contributing to the growing field of veterans studies. Discussion follows about research emerging from …
The Dynamic Trophic Niche Of An Island Bird Of Prey, Ulises Balza, Nicolas A. Lois, Michael J. Polito, Klemens Puetz, Amira Saalom, Andrea Raya Rey
The Dynamic Trophic Niche Of An Island Bird Of Prey, Ulises Balza, Nicolas A. Lois, Michael J. Polito, Klemens Puetz, Amira Saalom, Andrea Raya Rey
Faculty Publications
Optimal foraging theory predicts an inverse relationship between the availability of preferred prey and niche width in animals. Moreover, when individuals within a population have identical prey preferences and preferred prey is scarce, a nested pattern of trophic niche is expected if opportunistic and selective individuals can be identified. Here, we examined intraspecific variation in the trophic niche of a resident population of striated caracara (Phalcoboenus australis) on Isla de los Estados (Staten Island), Argentina, using pellet and stable isotope analyses. While this raptor specializes on seabird prey, we assessed this population's potential to forage on terrestrial prey, especially invasive …
Fish Assemblages Associated With Artificial Reefs Assessed Using Multiple Gear Types In The Northwest Gulf Of Mexico, Jeffrey D. Plumlee, Kaylan M. Dance, Michael A. Dance, Hay R. Rooker, Thomas C. Tinhan, J. Brooke Shipley, R. J. David Wells
Fish Assemblages Associated With Artificial Reefs Assessed Using Multiple Gear Types In The Northwest Gulf Of Mexico, Jeffrey D. Plumlee, Kaylan M. Dance, Michael A. Dance, Hay R. Rooker, Thomas C. Tinhan, J. Brooke Shipley, R. J. David Wells
Faculty Publications
Quantitative surveys of fishes associated with artificial reefs in the northwest Gulf of Mexico were conducted over a 4-yr period (2014-2017). Artificial reefs surveyed were comprised of three types: concrete structures, rig jackets, and decommissioned ships. All reefs were surveyed using vertical long line ( VLL), fish traps, and Adaptive Resolution Imaging Sonar (ARIS 1800). Mean fish abundance did not significantly differ using VLL [1.7 ind set(-1) (SD 2.2)] among the three reef types. However, relative abundance among all fishes collected was significantly highest on rig reefs using traps [6.2 ind soak(-1) (SD 3.8)], while results from sonar surveys indicated …
Tidal And Storm Impacts On Hydrodynamics And Sediment Dynamics In An Energetic Ebb Tidal Delta, Kehui Xu, P. Ansley Wren, Yanxia Ma
Tidal And Storm Impacts On Hydrodynamics And Sediment Dynamics In An Energetic Ebb Tidal Delta, Kehui Xu, P. Ansley Wren, Yanxia Ma
Faculty Publications
Bottom-mounted instrumentation was deployed at two sites on a large sandy shoal of an ebb tidal delta offshore of the Port Royal Sound of South Carolina of USA to collect hydrodynamics and sediment dynamics data. One site ("borrow site") was 2 km offshore in a dredge pit for nearby beach nourishment and the other site ("reference site") was 10 km offshore. In situ time-series data were collected during two periods after the dredging: 15 March-12 June (spring) and 18 August-18 November (fall) of 2012. Data at the reference site indicated active migrating bedforms from centimeters to decimeters tall, and sediment …
Application Of Otolith Chemistry At Multiple Life History Stages To Assess Population Structure Of Warsaw Grouper In The Gulf Of Mexico, P. J. Sanchez, J. R. Rooker, M. Zapp Sluis, J. Pinsky, M. A. Dance, B. Falterman, R. J. Allman
Application Of Otolith Chemistry At Multiple Life History Stages To Assess Population Structure Of Warsaw Grouper In The Gulf Of Mexico, P. J. Sanchez, J. R. Rooker, M. Zapp Sluis, J. Pinsky, M. A. Dance, B. Falterman, R. J. Allman
Faculty Publications
Chemical markers in otoliths have been used to assess the stock structure of many marine fishes, but these natural markers have yet to be widely evaluated or applied to demersal fishes in offshore habitats where physicochemical gradients are generally less pronounced relative to nearshore waters. To address this, we quantified trace elements (Li, Mg, Mn, Co, Cu, Zn, Sr, Ba) and stable isotopes (δ13C and δ18O) in otoliths of Warsaw grouper Hyporthodus nigritus from 4 regions in the Gulf of Mexico (Texas, Louisiana, Alabama−NW Florida, and SW Florida). Region-specific differences in otolith chemistry were observed, and …
Co-Worker Evidence In Court, Sandra F. Sperino
Co-Worker Evidence In Court, Sandra F. Sperino
Faculty Publications
This symposium explores ways to empower workers. Many employment laws rely on workers filing private rights of action to enforce the underlying substantive law. Unfortunately, when workers file these claims in court, courts often do not allow them to rely on evidence from their co-workers. While courts regularly allow employers to submit co-worker evidence of a plaintiff's poor performance or lack of qualifications, they often diminish or exclude a plaintiff's co-worker evidence that the plaintiff performed well or possessed desired qualifications. This Article identifies and explores this evidentiary inequality. It argues that efforts to empower workers must include the power …
Backbone And Sidechain Resonance Assignments And Secondary Structure Of Scc4 From Chlamydia Trachomatis, Thilini O. Ukwaththage, Marco Tonelli, Megan A. Macnaughtan
Backbone And Sidechain Resonance Assignments And Secondary Structure Of Scc4 From Chlamydia Trachomatis, Thilini O. Ukwaththage, Marco Tonelli, Megan A. Macnaughtan
Faculty Publications
© 2020, Springer Nature B.V. Chlamydia trachomatis is an obligate intracellular bacterium that causes the most common sexually transmitted bacterial diseases in the world. With a biphasic developmental cycle, the bacteria utilize a type III secretion system (T3SS) to invade host cells as infectious elemental bodies, which then differentiate into actively dividing reticulate bodies. The regulation of the developmental cycle and the T3SS are linked by the bi-functional protein, specific Chlamydia chaperone 4 (Scc4). Scc4 is a class I T3SS chaperone forming a heterodimer with specific Chlamydia chaperone 1 (Scc1) to chaperone the essential virulence effector, Chlamydia outer membrane protein …
Expression, Purification, And Glycosylation Of Epidermal Growth Factor-Like Repeat 27 From Mouse Notch1, Justin A. Grennell, Kendra D. Jenkins, Huimin Zhong, Amid Paudyal, Kelvin B. Luther, Robert S. Haltiwanger, Megan A. Macnaughtan
Expression, Purification, And Glycosylation Of Epidermal Growth Factor-Like Repeat 27 From Mouse Notch1, Justin A. Grennell, Kendra D. Jenkins, Huimin Zhong, Amid Paudyal, Kelvin B. Luther, Robert S. Haltiwanger, Megan A. Macnaughtan
Faculty Publications
© 2020 Elsevier Inc. Notch receptors have large extracellular domains containing up to 36 tandem epidermal growth factor-like (EGF) repeats, which facilitate cell signaling by binding ligands on neighboring cells. Notch receptors play major roles in a variety of developmental processes by controlling cell fate decisions. Each EGF repeat consists of about 40 amino acids with 3 conserved disulfide bonds. Many of the EGF repeats are modified by O-linked fucose glycans, and more than half have calcium-binding sites, but the sequences of the EGF repeats vary giving distinct roles to each repeat. EGF repeat 27 (EGF27) from mouse NOTCH1 is …
The Central Role Of Taxonomy In The Study Of Neotropical Biodiversity1, Laura P. Lagomarsino, Laura A. Frost
The Central Role Of Taxonomy In The Study Of Neotropical Biodiversity1, Laura P. Lagomarsino, Laura A. Frost
Faculty Publications
© 2020 Missouri Botanical Garden. All rights reserved. The Neotropics are the most species-rich area of the planet. Understanding the origin and maintenance of this diversity is an important goal of ecology and evolutionary biology. Success in this endeavor relies heavily on the past work of taxonomists who have collected specimens and produced the floras and monographs that constitute the foundation for the study of plant diversity. To illustrate this, we visualize collecting efforts through time and identify the importance of past taxonomic and collection efforts in generating the bulk of specimen data that broad-scale analyses rely on today. To …
Abundance Of The Species Clostridium Butyricum In The Gut Microbiota Contributes To Differences In Obesity Phenotype In Outbred Sprague-Dawley Cd Rats, Diana N. Obanda, Claudia Husseneder, Anne M. Raggio, Ryan Page, Brian Marx, Rhett W. Stout, Justin Guice, Diana Coulon, Michael J. Keenan
Abundance Of The Species Clostridium Butyricum In The Gut Microbiota Contributes To Differences In Obesity Phenotype In Outbred Sprague-Dawley Cd Rats, Diana N. Obanda, Claudia Husseneder, Anne M. Raggio, Ryan Page, Brian Marx, Rhett W. Stout, Justin Guice, Diana Coulon, Michael J. Keenan
Faculty Publications
© 2020 Elsevier Inc. Objectives: Gut microbiota profiles contribute to differences in obesity phenotype. We examined the abundance of the species Clostridium butyricum in relation to obesity phenotype. Methods: In outbred Sprague -Dawley rats we examined effects of dietary fat, resistant starch (RS), and a microbiota transplant on obesity phenotype. Using targeted qPCR, we examined the abundance of total gut bacteria and C. butyricum in relation to the propensity of obesity prone and obesity resistant rats to accumulate abdominal fat. Results: Before inclusion of dietary RS, obesity resistant (OR) rats had higher amounts of total bacteria, and C. butyricum compared …
Abundance Of The Species Clostridium Butyricum In The Gut Microbiota Contributes To Differences In Obesity Phenotype In Outbred Sprague-Dawley Cd Rats, Diana N. Obanda, Claudia Husseneder, Anne M. Raggio, Ryan Page, Brian Marx, Rhett W. Stout, Justin Guice, Diana Coulon, Michael J. Keenan
Abundance Of The Species Clostridium Butyricum In The Gut Microbiota Contributes To Differences In Obesity Phenotype In Outbred Sprague-Dawley Cd Rats, Diana N. Obanda, Claudia Husseneder, Anne M. Raggio, Ryan Page, Brian Marx, Rhett W. Stout, Justin Guice, Diana Coulon, Michael J. Keenan
Faculty Publications
© 2020 Elsevier Inc. Objectives: Gut microbiota profiles contribute to differences in obesity phenotype. We examined the abundance of the species Clostridium butyricum in relation to obesity phenotype. Methods: In outbred Sprague -Dawley rats we examined effects of dietary fat, resistant starch (RS), and a microbiota transplant on obesity phenotype. Using targeted qPCR, we examined the abundance of total gut bacteria and C. butyricum in relation to the propensity of obesity prone and obesity resistant rats to accumulate abdominal fat. Results: Before inclusion of dietary RS, obesity resistant (OR) rats had higher amounts of total bacteria, and C. butyricum compared …
The Anti-Hiv Drug Nelfinavir Mesylate (Viracept) Is A Potent Inhibitor Of Cell Fusion Caused By The Sarscov-2 Spike (S) Glycoprotein Warranting Further Evaluation As An Antiviral Against Covid-19 Infections, Farhana Musarrat, Vladimir Chouljenko, Achyut Dahal, Rafiq Nabi, Tamara Chouljenko, Seetharama D. Jois, Konstantin G. Kousoulas
The Anti-Hiv Drug Nelfinavir Mesylate (Viracept) Is A Potent Inhibitor Of Cell Fusion Caused By The Sarscov-2 Spike (S) Glycoprotein Warranting Further Evaluation As An Antiviral Against Covid-19 Infections, Farhana Musarrat, Vladimir Chouljenko, Achyut Dahal, Rafiq Nabi, Tamara Chouljenko, Seetharama D. Jois, Konstantin G. Kousoulas
Faculty Publications
© 2020 Wiley Periodicals LLC Severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) is the causative agent of the coronavirus disease-2019 (COVID-19) pandemic. Coronaviruses enter cells via fusion of the viral envelope with the plasma membrane and/or via fusion of the viral envelope with endosomal membranes after virion endocytosis. The spike (S) glycoprotein is a major determinant of virus infectivity. Herein, we show that the transient expression of the SARS CoV-2 S glycoprotein in Vero cells caused extensive cell fusion (formation of syncytia) in comparison to limited cell fusion caused by the SARS S glycoprotein. Both S glycoproteins were detected intracellularly …
Secure High Der Penetration Power Distribution Via Autonomously Coordinated Volt/Var Control, Anto Joseph, Keyue Smedley, Shahab Mehraeen
Secure High Der Penetration Power Distribution Via Autonomously Coordinated Volt/Var Control, Anto Joseph, Keyue Smedley, Shahab Mehraeen
Faculty Publications
Traditionally voltage control in distribution power system (DPS) is performed through voltage regulating devices (VRDs) including on load tap changers (OLTCs), step voltage regulators (SVRs), and switched capacitor banks (SCBs). The recent IEEE 1547-2018 from March 2018 requires inverter fed distributed energy resources (DERs) to contribute reactive power to support the grid voltage. To accommodate VAR from DERs, well-organized control algorithm is required to use in this mode to avoid grid oscillations and unintended switching operations of VRDs. This paper presents two voltage control strategies (i) static voltage control considering voltage-reactive power mode (IEEE 1547-2018), (ii) dynamic and extensive voltage …
Skeletal And Muscular Pelvic Morphology Of Hillstream Loaches (Cypriniformes: Balitoridae), Callie H. Crawford, Zachary S. Randall, Pamela B. Hart, Lawrence M. Page, Prosanta Chakrabarty, Apinun Suvarnaraksha, Brooke E. Flammang
Skeletal And Muscular Pelvic Morphology Of Hillstream Loaches (Cypriniformes: Balitoridae), Callie H. Crawford, Zachary S. Randall, Pamela B. Hart, Lawrence M. Page, Prosanta Chakrabarty, Apinun Suvarnaraksha, Brooke E. Flammang
Faculty Publications
© 2020 Wiley Periodicals LLC The rheophilic hillstream loaches (Balitoridae) of South and Southeast Asia possess a range of pelvic girdle morphologies, which may be attributed to adaptations for locomotion against rapidly flowing water. Specifically, the connectivity of the pelvic plate (basipterygium) to the vertebral column via a sacral rib, and the relative size and shape of the sacral rib, fall within a spectrum of three discrete morphotypes: long, narrow rib that meets the basipterygium; thicker, slightly curved rib meeting the basipterygium; and robust crested rib interlocking with the basipterygium. Species in this third category with more robust sacral rib …
All-Atomic Molecular Dynamic Studies Of Human And Drosophila Cdk8: Insights Into Their Kinase Domains, The Lxxll Motifs, And Drug Binding Site, Wu Xu, Xiao-Jun Xie, Ali K. Faust, Mengmeng Liu, Xiao Li, Feng Chen, Ashlin A. Naquin, Avery C. Walton, Peter W. Kishbaugh, Jun-Yuan Ji
All-Atomic Molecular Dynamic Studies Of Human And Drosophila Cdk8: Insights Into Their Kinase Domains, The Lxxll Motifs, And Drug Binding Site, Wu Xu, Xiao-Jun Xie, Ali K. Faust, Mengmeng Liu, Xiao Li, Feng Chen, Ashlin A. Naquin, Avery C. Walton, Peter W. Kishbaugh, Jun-Yuan Ji
Faculty Publications
Cyclin-dependent kinase 8 (CDK8) and its regulatory partner Cyclin C (CycC) play conserved roles in modulating RNA polymerase II (Pol II)-dependent gene expression. To understand the structure and function relations of CDK8, we analyzed the structures of human and Drosophila CDK8 proteins using molecular dynamics simulations, combined with functional analyses in Drosophila. Specifically, we evaluated the structural differences between hCDK8 and dCDK8 to predict the effects of the LXXLL motif mutation (AQKAA), the P154L mutations, and drug binding on local structures of the CDK8 proteins. First, we have observed that both the LXXLL motif and the kinase activity of CDK8 …
Dietary Methionine Restriction Signals To The Brain Through Fibroblast Growth Factor 21 To Regulate Energy Balance And Remodeling Of Adipose Tissue, Laura A. Forney, Han Fang, Landon C. Sims, Kirsten P. Stone, Leighann Y. Vincik, Alicia M. Vick, Amanda N. Gibson, David H. Burk, Thomas W. Gettys
Dietary Methionine Restriction Signals To The Brain Through Fibroblast Growth Factor 21 To Regulate Energy Balance And Remodeling Of Adipose Tissue, Laura A. Forney, Han Fang, Landon C. Sims, Kirsten P. Stone, Leighann Y. Vincik, Alicia M. Vick, Amanda N. Gibson, David H. Burk, Thomas W. Gettys
Faculty Publications
© 2020 The Obesity Society. Objective: Restricting dietary methionine to 0.17% in mice increases energy expenditure (EE), reduces fat deposition, and improves metabolic health by increasing hepatic fibroblast growth factor 21 (FGF21). The goal of this study was to compare each of these responses in mice with the coreceptor for FGF21 deleted in either adipose tissue or the brain. Methods: Methionine-restriction (MR) diets were fed to age-matched cohorts of mice with the coreceptor for FGF21 deleted in either adipose tissue or the brain. The physiological and transcriptional responses to MR were compared in the respective cohorts. Results: Tissue-specific deletion of …
Two More Plumbers Look At The Leak: Purchasing An Annuity In An Institutionalized Spouse's Ira That Is Irrevocably Payable To The Community Spouse May Work For Medicaid Purposes But Runs A Risk Of Adverse Tax Treatment, David M. English, Ron M. Landsman
Two More Plumbers Look At The Leak: Purchasing An Annuity In An Institutionalized Spouse's Ira That Is Irrevocably Payable To The Community Spouse May Work For Medicaid Purposes But Runs A Risk Of Adverse Tax Treatment, David M. English, Ron M. Landsman
Faculty Publications
A recent article in NAELA ]ournal addressed the problem of how to maximize Medicaid benefits and minimize the tax burden for an institutionalized spouse who has a substantial individual retirement account (IRA) in a state where the account is not exempt. The primary problem is that most strategies require that the IRA be cashed out, triggering income tax liability for the entire withdrawal for that tax year. Once the IRA is cashed out, the proceeds can be spent down in any number of ways; one option is for the community spouse to purchase a Medicaid qualified annuity (MQA). The proposed …
Covid-19 And Its Impact On America's Retirement System, David M. English
Covid-19 And Its Impact On America's Retirement System, David M. English
Faculty Publications
There is a long-standing debate over whether America's retirement system is in crisis. The COVID-19 pandemic has resolved the debate. Perhaps the system was merely challenged prior to March 2020, but it is certainly in crisis now. The pandemic has negatively impacted all four of the principal pillars of retirement: Social Security, employer-sponsored retirement programs, earnings from part-time work, and the worker's own savings. This short article will discuss the impact of the pandemic on the retirement system and discuss possible ways to restore the system to health or at least ameliorate the damage.
African American Emerging Adult Perspectives On Unintended Pregnancy And Meeting Their Needs With Mobile Technology: Mixed Methods Qualitative Study, Lucy Annang Ingram, Crystal Stafford, Quentin Mccollum, Mckenzie Isreal
African American Emerging Adult Perspectives On Unintended Pregnancy And Meeting Their Needs With Mobile Technology: Mixed Methods Qualitative Study, Lucy Annang Ingram, Crystal Stafford, Quentin Mccollum, Mckenzie Isreal
Faculty Publications
Background: In the United States, a disproportionate number of unintended pregnancies occur among African Americans, particularly those in their later teenage years and early 20s. Mobile technology is becoming more ubiquitous as a method for health promotion; however, relatively little research has been done with this population to determine their perspectives about unintended pregnancy, the potential of successfully using mobile technology to prevent unintended pregnancy, and the content of such programs.
Objective: The purpose of this study was to obtain the perspectives of African American emerging adults about unintended pregnancy and the use of mobile technology to reduce unintended pregnancy …