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Author Correction: Past Continental Shelf Evolution Increased Antarctic Ice Sheet Sensitivity To Climatic Conditions (Scientific Reports, (2018), 8, 1, (11323), 10.1038/S41598-018-29718-7), Florence Colleoni, Laura De Santis, Enea Montoli, Elisabetta Olivo, Christopher C. Sorlien, Philip J. Bart, Edward G.W. Gasson, Andrea Bergamasco, Chiara Sauli, Nigel Wardell, Stefano Prato

Faculty Publications

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Evidence Of Metasomatism In The Interior Of Vesta, Ai Cheng Zhang, Noriyuki Kawasaki, Huiming Bao, Jia Liu, Liping Qin, Minami Kuroda, Jian Feng Gao, Li Hui Chen, Ye He, Naoya Sakamoto, Hisayoshi Yurimoto

Faculty Publications

© 2020, The Author(s). Diogenites are a group of meteorites that are derived from the interior of the largest protoplanet Vesta. They provide a unique opportunity to understanding together the internal structure and dynamic evolution of this protoplanet. Northwest Africa (NWA) 8321 was suggested to be an unbrecciated noritic diogenite meteorite, which is confirmed by our oxygen and chromium isotopic data. Here, we find that olivine in this sample has been partly replaced by orthopyroxene, troilite, and minor metal. The replacement texture of olivine is unambiguous evidence of sulfur-involved metasomatism in the interior of Vesta. The presence of such replacement …

First-Principles Computation Of Diffusional Mg Isotope Fractionation In Silicate Melts, Haiyang Luo, Bijaya B. Karki, Dipta B. Ghosh, Huiming Bao

Faculty Publications

© 2020 Elsevier Ltd Diffusional isotope fractionation occurs in geochemical processes (such as magma mixing, bubble growth, and crystal growth), even at magmatic temperatures. Isotopic mass dependence of diffusion is commonly expressed as [Formula presented], where Di and Dj are diffusion coefficients of two isotopes whose masses are mi and mj. How the dimensionless empirical parameter β depends on temperature, pressure, and composition remains poorly constrained. Here, we conducted a series of first-principles molecular dynamics simulations to evaluate the β factor of Mg isotopes in MgSiO3 and Mg2SiO4 melts using pseudo-isotope method. In particular, we considered interactions between Mg isotopes …

Evidence Of Metasomatism In The Interior Of Vesta, Ai Cheng Zhang, Noriyuki Kawasaki, Huiming Bao, Jia Liu, Liping Qin, Minami Kuroda, Jian Feng Gao, Li Hui Chen, Ye He, Naoya Sakamoto, Hisayoshi Yurimoto

Faculty Publications

© 2020, The Author(s). Diogenites are a group of meteorites that are derived from the interior of the largest protoplanet Vesta. They provide a unique opportunity to understanding together the internal structure and dynamic evolution of this protoplanet. Northwest Africa (NWA) 8321 was suggested to be an unbrecciated noritic diogenite meteorite, which is confirmed by our oxygen and chromium isotopic data. Here, we find that olivine in this sample has been partly replaced by orthopyroxene, troilite, and minor metal. The replacement texture of olivine is unambiguous evidence of sulfur-involved metasomatism in the interior of Vesta. The presence of such replacement …

Exceptional Sulfur And Iron Isotope Enrichment In Millimetre-Sized, Early Palaeozoic Animal Burrows, Dario Harazim, Joonas J. Virtasalo, Kathryn C. Denommee, Nicolas Thiemeyer, Yann Lahaye, Martin J. Whitehouse

Faculty Publications

© 2020, The Author(s). Pyrite-δ34S and -δ56Fe isotopes represent highly sensitive diagnostic paleoenvironmental proxies that express high variability at the bed (< 10 mm) scale that has so far defied explanation by a single formative process. This study reveals for the first time the paleoenvironmental context of exceptionally enriched pyrite-δ34S and -δ56Fe in bioturbated, storm-reworked mudstones of an early Ordovician storm-dominated delta (Tremadocian Beach Formation, Bell Island Group, Newfoundland). Very few studies provide insight into the low-temperature sulfur and iron cycling from bioturbated muddy settings for time periods prior to the evolution of deep soil horizons on land. Secondary ion mass spectroscopy (SIMS) analyses performed on Beach Formation muddy storm event beds reveal spatially distinct δ34S and δ56Fe values in: (a) tubular biogenic structures and trails (δ34S ~ +40‰; δ56Fe ~ −0.5‰), (b) silt-filled Planolites burrows (δ34S ~ +40‰; δ56Fe ~ +0.5 to + 2.1‰), and (c) non-bioturbated mudstone (δ34S ~ +35‰; δ56Fe ~ +0.5‰). δ34S values of well above + 40.0‰ indicate at least some pyrite precipitation in the presence of a 34S-depleted pore water sulfide reservoir, via closed system (Raleigh-type) fractionation. The preferential enrichment of 56Fe in Planolites burrows is best explained via microbially-driven liberation of Fe(II) from solid iron parent phases and precipitation from a depleted 54Fe dissolved Fe(II) reservoir. Rigorous sedimentological analysis represents a gateway to critically test the paleoenvironmental models describing the formation of a wide range of mudstones and elucidates the origins of variability in the global stable S and Fe isotope record.

Associative Nitrogen Fixation Linked With Three Perennial Bioenergy Grasses In Field And Greenhouse Experiments, Jayani J. Wewalwela, Yuan Tian, Janet R. Donaldson, Brian S. Baldwin, Jac J. Varco, Brett Rushing, Haoliang Lu, Mark A. Williams

Faculty Publications

© 2020 The Authors. Associative nitrogen (N₂)‐fixation (ANF) by bacteria in the root‐zone of perennial bioenergy grasses has the potential to replace or supplement N fertilizer and support sustainable production of biomass, but its application in marginal ecosystems requires further evaluation. In this study, we first combined both greenhouse and field experiments, to explore the N₂ fixation effects of three temperate feedstocks Miscanthus × giganteus (giant miscanthus, Freedom), Panicum virgatum (switchgrass, Alamo), and Saccharum sp. (energycane, Ho 02‐147). In field studies across three growing seasons, plant and soil pools of candidate feedstocks were partially composed of N …

The Roles Of Osteopontin In The Pathogenesis Of West Nile Encephalitis, Farzana Nazneen, Fengwei Bai

Faculty Publications

Osteopontin (OPN), a multifunctional protein encoded by the secreted phosphoprotein-1 (Spp-1) gene in humans, plays important roles in a variety of physiological conditions, such as biomineralization, bone remodeling and immune functions. OPN also has significant roles in the pathogenesis of autoimmune, allergy and inflammatory diseases, as well as bacterial, fungal and viral infections. West Nile virus (WNV), a mosquito-transmitted flavivirus, is the leading agent for viral encephalitis in North America. Recent progress has been made in understanding both the biological functions of OPN and the pathogenesis of WNV. In this review article, we have summarized the current understanding of the …

The Role Of The Msaabcr Operon In Implant-Associated Chronic Osteomyelitis In Staphylococcus Aureus Usa300 Lac, Gyan S. Sahukhal, Michelle Tucci, Hamed Benghuzzi, Gerri Wilson, Mohamed O. Elasri

Faculty Publications

The msaABCR operon regulates several staphylococcal phenotypes such as biofilm formation, capsule production, protease production, pigmentation, antibiotic resistance, and persister cells formation. The msaABCR operon is required for maintaining the cell wall integrity via affecting peptidoglycan cross-linking. The msaABCR operon also plays a role in oxidative stress defense mechanism, which is required to facilitate persistent and recurrent staphylococcal infections. Staphylococcus aureus is the most frequent cause of chronic implant-associated osteomyelitis (OM). The CA-MRSA USA300 strains are predominant in the United States and cause severe infections, including bone and joint infections.

Noise And Detectivity Limits In Organic Shortwave Infrared Photodiodes With Low Disorder, Zhenghui Wu, Ning Li, Naresh Eedugurala, Jason D. Azoulay, Dong Seok Leem, Tse Nga Ng

Faculty Publications

© 2020, The Author(s). To achieve high detectivity in infrared detectors, it is critical to reduce the device noise. However, for non-crystalline semiconductors, an essential framework is missing to understand and predict the effects of disorder on the dark current. This report presents experimental and modeling studies on the noise current in exemplar organic bulk heterojunction photodiodes, with 10 donor–acceptor combinations spanning wavelength between 800 and 1600 nm. A significant reduction of the noise and higher detectivity were found in devices using non-fullerene acceptors (NFAs) in comparison to those using fullerene derivatives. The low noise in NFA blends was attributed …

Understanding Impacts Of Groundwater Dynamics On Flooding And Levees In Greater New Orleans, Shuo Yang, Frank T.C. Tsai

Faculty Publications

Study region: The Greater New Orleans in southeastern Louisiana, USA. Study focus: Flooding is a major threat to New Orleans due to its geographic location and geologic condition. However, potential groundwater flooding is seldom studied and poorly understood. This study investigated potential groundwater flooding and seepage-induced hazards to levees in New Orleans. High-fidelity stratigraphy and groundwater models were developed to investigate groundwater dynamics and identify areas prone to groundwater flooding and low levee factor of safety. New hydrological insights for the region: The stratigraphy model showed that 74 % of shallow sediments in New Orleans are fine grains and noticeable …

Court-Appointment Compensation And Rural Access To Justice, Hannah Haksgaard

Faculty Publications

Hourly rates paid to court-appointed lawyers impact access to justice. Court appointed lawyers provide necessary counsel in civil and criminal cases, yet hourly rates in many jurisdictions are so low that many lawyers cannot afford to take court-appointed cases. This article argues that low hourly rates cause problems: namely, appointed lawyers will be insufficient in number, inaccessible to their clients, and sometimes even ineffective. These problems are heightened in rural America where they are compounded by geographical distance and the rural lawyer shortage. This article concludes by suggesting a number of policy solutions.

Pressure Falloff Testing To Characterize Co2 Plume And Dry-Out Zone During Co2 Injection In Saline Aquifers, Mohamed Abdelaal, Mehdi Zeidouni

Faculty Publications

The fluid mobilities and the lateral extent of the CO2 plume and the dry-out zone are among important unknowns required to effectively manage CO2 storage in saline aquifers projects. These unknowns can be derived from pressure falloff testing which has been widely used to characterize the subsurface. This work provides a three-region analytical solution for falloff pressure during the infinite-acting period of CO2 injection in saline aquifers. The solution is derived using Laplace transformation technique of the governing diffusivity equations and the accompanying initial and boundary conditions. The exact solution is validated against numerical results obtained from a black-oil reservoir …

Structure–Activity Relationship-Based Chemical Classification Of Highly Imbalanced Tox21 Datasets, Gabriel Idakwo, Sundar Thangapandian, Joseph Luttrell, Yan Li, Nan Wang, Zhaoxian Zhou, Huixiao Hong, Bei Yang, Chaoyang Zhang, Ping Gong

Faculty Publications

The specificity of toxicant-target biomolecule interactions lends to the very imbalanced nature of many toxicity datasets, causing poor performance in Structure–Activity Relationship (SAR)-based chemical classification. Undersampling and oversampling are representative techniques for handling such an imbalance challenge. However, removing inactive chemical compound instances from the majority class using an undersampling technique can result in information loss, whereas increasing active toxicant instances in the minority class by interpolation tends to introduce artificial minority instances that often cross into the majority class space, giving rise to class overlapping and a higher false prediction rate. In this study, in order to improve the …

External Stoma Diversion: A Palliative Measure For Peristomal Wound Healing In Resource-Limited Settings, Rachel W. Davis, Youmna A. Sherif, Catherine Anne Morrison

Faculty Publications

The provision of intestinal stoma care is challenging in austere settings due to limitations in surgical and wound care access as well as the high cost and sparsity of ostomy supplies. As a result, many surgical patients suffer from ostomy-related complications such as peristomal wounds and are unable to find relief for these complications from standard treatments and measures. This article describes the external stoma diversion, a cost-effective palliative surgical procedure that assists in the healing of peristomal wounds in resource-limited settings.

The Effect Of Summer Drought On The Predictability Of Local Extinctions In A Butterfly Metapopulation, Erik Van Bergen, Tad Dallas, Michelle F. Dileo, Aapo Kahilainen, Anniina L.K. Mattila, Miska Luoto, Marjo Saastamoinen

Faculty Publications

The ecological impacts of extreme climatic events on population dynamics and community composition are profound and predominantly negative. Using extensive data of an ecological model system, we tested whether predictions from ecological models remain robust when environmental conditions are outside the bounds of observation. We observed a 10-fold demographic decline of the Glanville fritillary butterfly (Melitaea cinxia) metapopulation on the Åland islands, Finland in the summer of 2018 and used climatic and satellite data to demonstrate that this year was an anomaly with low climatic water balance values and low vegetation productivity indices across Åland. Population growth rates …

Dystonia 16 (Dyt16) Mutations In Pact Cause Dysregulated Pkr Activation And Eif2Α Signaling Leading To A Compromised Stress Response, Samuel B. Burnett, Lauren S. Vaughn, Nutan Sharma, Ronit Kulkarni, Rekha C. Patel

Faculty Publications

Dystonia 16 (DYT16) is caused by mutations in PACT, the protein activator of interferon-induced double-stranded RNA-activated protein kinase (PKR). PKR regulates the integrated stress response (ISR) via phosphorylation of the translation initiation factor eIF2α. This post-translational modification attenuates general protein synthesis while concomitantly triggering enhanced translation of a few specific transcripts leading either to recovery and homeostasis or cellular apoptosis depending on the intensity and duration of stress signals. PKR plays a regulatory role in determining the cellular response to viral infections, oxidative stress, endoplasmic reticulum (ER) stress, and growth factor deprivation. In the absence of stress, both PACT and …

Parkindex: Validation And Application Of A Pragmatic Measure Of Park Access And Use, Andrew T. Kaczynski, S. Morgan Hughey, Ellen W. Stowe, Marilyn E. Wende, J. Aaron Hipp, Elizabeth L. Oliphant, Jasper Schipperijn

Faculty Publications

Composite metrics integrating park availability, features, and quality for a given address or neighborhood are lacking. The purposes of this study were to describe the validation, application, and demonstration of ParkIndex in four diverse communities. This study occurred in Fall 2018 in 128 census block groups within Seattle(WA), Brooklyn(NY), Raleigh(NC), and Greenville County(SC). All parks within a half-mile buffer were audited to calculate a composite park quality score, and select households provided data about use of proximal parks via an online, map-based survey. For each household, the number of parks, total park acreage, and average park quality score within one …

Monitoring The Spatial Spread Of Covid-19 And Effectiveness Of Control Measures Through Human Movement Data: Proposal For A Predictive Model Using Big Data Analytics, Zhenlong Li, Xiaoming Li, Dwayne Porter Ph.D., Jiajia Zhang Ph.D., Yuqin Jiang, Bankole Olatosi Ph.D., Sharon Weissman

Faculty Publications

Background: Human movement is one of the forces that drive the spatial spread of infectious diseases. To date, reducing and tracking human movement during the COVID-19 pandemic has proven effective in limiting the spread of the virus. Existing methods for monitoring and modeling the spatial spread of infectious diseases rely on various data sources as proxies of human movement, such as airline travel data, mobile phone data, and banknote tracking. However, intrinsic limitations of these data sources prevent us from systematic monitoring and analyses of human movement on different spatial scales (from local to global). Objective: Big data from social …

A Patient-Centered Asthma Management Communication Intervention For Rural Latino Children: Protocol For A Waiting-List Randomized Controlled Trial, Robin Dawson, Sue P. Heiney, De Anne Hilfinger Messias, Dennis Ownby

Faculty Publications

Background: Rural Latino children with asthma suffer high rates of uncontrolled asthma symptoms, emergency department visits, and repeat hospitalizations. This vulnerable population must negotiate micro- and macrolevel challenges that impact asthma management, including language barriers, primary care access, parental time off from work, insurance coverage, distance from specialty sites, and documentation status. There are few proven interventions that address asthma management embedded within this unique context. Objective: Using a bio-ecological approach, we will determine the feasibility of a patient-centered collaborative program between rural Latino children with asthma and their families, school-based nursing programs, and primary care providers, facilitated by the …

Eager To Follow: Methodological Precedent In Statutory Interpretation, Aaron-Andrew P. Bruhl

Faculty Publications

An important recent development in the field of statutory interpretation is the emergence of a movement calling for "methodological precedent"--a regime under which courts give precedential effect to interpretive methodology. In such a system, a case would establish not only what a particular statute means but could also establish binding rules of methodology--which tools are valid, in what order, and so on. The movement for methodological precedent has attracted sharp criticism on normative grounds. But both sides of the normative debate agree on the premise that the federal courts generally do not give precedential effect to interpretive methodology today.

This …

Punishing Pill Mill Doctors: Sentencing Disparities In The Opioid Epidemic, Adam M. Gershowitz

Faculty Publications

Consider two pill mill doctors who flooded the streets with oxycodone and other dangerous opioids. The evidence against both doctors was overwhelming. They each sold millions of opioid pills. Both doctors charged addicted patients hundreds of dollars in cash for office visits that involved no physical examinations and no diagnostic tests. Instead, the doctors simply handed the patients opioids in exchange for cash. To maximize their income, both doctors conspired with street dealers to import fake patients — many of them homeless — so that the doctors could write even more prescriptions. Both doctors made millions of dollars profiting off …

From Obstacles To Opportunities: Churches Rising Above The Challenges Of Covid-19, S. Joseph Kidder, Willie Edward Hucks Ii

Faculty Publications

No abstract provided.

Biochemical And Genetic Analysis Of Ecm14, A Conserved Fungal Pseudopeptidase, R. Christian Mcdonald, Matthew James Schott, Temitope A. Idowu, Peter J. Lyons

Faculty Publications

© 2020, The Author(s). Background: Like most major enzyme families, the M14 family of metallocarboxypeptidases (MCPs) contains a number of pseudoenzymes predicted to lack enzyme activity and with poorly characterized molecular function. The genome of the yeast Saccharomyces cerevisiae encodes one member of the M14 MCP family, a pseudoenzyme named Ecm14 proposed to function in the extracellular matrix. In order to better understand the function of such pseudoenzymes, we studied the structure and function of Ecm14 in S. cerevisiae. Results: A phylogenetic analysis of Ecm14 in fungi found it to be conserved throughout the ascomycete phylum, with a group of …

Engaging Empirical Dynamic Modeling To Detect Intrusions In Cyber-Physical Systems, David R. Crow, Scott R. Graham, Brett J. Borghetti, Patrick J. Sweeney

Faculty Publications

Modern cyber-physical systems require effective intrusion detection systems to ensure adequate critical infrastructure protection. Developing an intrusion detection capability requires an understanding of the behavior of a cyber-physical system and causality of its components. Such an understanding enables the characterization of normal behavior and the identification and reporting of anomalous behavior. This chapter explores a relatively new time series analysis technique, empirical dynamic modeling, that can contribute to system understanding. Specifically, it examines if the technique can adequately describe causality in cyber-physical systems and provides insights into it serving as a foundation for intrusion detection.

An Analysis Of The Benefits And Difficulties Of Aerial Magnetic Vector Navigation, Aaron J. Canciani, Christopher J. Brennan

Faculty Publications

Recent successful flight tests have demonstrated scalar magnetic anomaly navigation to be a viable GPS-alternative navigation system. These flight tests matched magnetic field measurements to maps of the Earth's crustal magnetic field in order to navigate. Scalar magnetic navigation uses only the magnetic field intensity, not direction, in order to navigate. While it appears obvious to extend aerial magnetic navigation to use the full vector field, in practice there are substantial obstacles to doing so. This article explores the key challenges of magnetic vector navigation including current sensor limitations, lack of high frequency magnetic vector maps of the Earth's crust, …

Homotopy Simulation Of Dissipative Micropolar Flow And Heat Transfer From A Two-Dimensional Body With Heat Sink Effect: Applications In Polymer Coating, O. A. Bég, B. Vasu, A. K. Ray, T. A. Beg, A. Kadir, H. J. Leonard, Rama S. R. Gorla

Faculty Publications

Non-Newtonian flow from a wedge constitutes a fundamental problem in chemical engineering systems and is relevant to processing of polymers, coating systems, etc. Motivated by such applications, the homotopy analysis method (HAM) was employed to obtain semi-analytical solutions for thermal convection boundary layer flow of incompressible micropolar fluid from a two-dimensional body (wedge). Viscous dissipation and heat sink effects were included. The non-dimensional boundary value problem emerges as a system of nonlinear coupled ordinary differential equations, by virtue of suitable coordinate transformations. The so-called Falkner-Skan flow cases are elaborated. Validation of the HAM solutions was achieved with earlier simpler models, …

Swarm-Based Design Of Proportional Integral And Derivative Controllers Using A Compromise Cost Function: An Arduino Temperature Laboratory Case Study, Paulo De Moura Oliveira, John Hedengren, Eduardo Solteiro Pires

Faculty Publications

Simple and easy to use methods are of great practical demand in the design of Proportional, Integral, and Derivative (PID) controllers. Controller design criteria are to achieve a good set-point tracking and disturbance rejection with minimal actuator variation. Achieving satisfactory trade-offs between these performance criteria is not easily accomplished with classical tuning methods. A particle swarm optimization technique is proposed to design PID controllers. The design method minimizes a compromise cost function based on both the integral absolute error and control signal total variation criteria. The proposed technique is tested on an Arduino-based Temperature Control Laboratory (TCLab) and compared with …

Variedades: Intermediate/Advanced Spanish Conversation, Carmela V. Mattza

Faculty Publications

VARIEDADES is a Spanish conversation book for the student at the intermediate / advanced intermediate level (DELE nivel B2). Through audiovisual activities, the student is expected to put their previous knowledge into practice and continue to develop their ability to understand, write, listen and speak in Spanish.

VARIEDADES offers communicative activities that can be easily adapted into courses of different levels. In addition, it offers an appendix of activities with films and a Spanish grammar section that by subject directs the student to electronic databases that are freely accessible or are part of the Open Access platform

This Is My Vision’: How Students Depict Critiques Along With Themselves During Critiques, Jason K. Mcdonald, Esther Michela

Faculty Publications

In this article we consider critiques within the design studio as how students press forward into possible forms of the self that are opened up through studio participation. We contrast this with a view of critiques as primarily being a pedagogical or socialising technique under the control of instructors and other critics. We carried out our inquiry using interviews with six studio students, studying how they depict critiques and how they depict themselves when being critiqued. Students’ depictions of critiques included their being: a) signal in the noise; b) windows into their critics’ character; c) a type of text to …

Chloramination Of Iopamidol- And Bromide-Spiked Waters Containing Natural Organic Matter, Nana Osei B Ackerson, Hannah K. Liberatore, Susan D. Richardson, Micheal J. Plewa, Thomas A. Ternes, Stephen E. Duirk

Faculty Publications

Iopamidol (an iodinated X-ray contrast medium) and bromide are precursors in the formation of halogenated disinfection byproducts (DBPs). The interactions of these precursors are vital to elucidate the formation of halogenated DBPs during chloramination. This work investigated the formation of total organic halogen and select individual DBPs in two laboratory-chloraminated source waters containing iopamidol and bromide. Experiments were carried out in batch reactors containing Barberton source water (BSW) and Cleveland BSW (CSW), spiked with iopamidol (5 mu M), bromide (15 mu M), and 100 mu M monochloramine. Total organic iodine concentrations were approximately equal regardless of source water since they …