Digital Commons Network^™

Consequences To Patients, Clinicians, And Manufacturers When Very Serious Adverse Drug Reactions Are Identified (1997-2019): A Qualitative Analysis From The Southern Network On Adverse Reactions (Sonar), Charles L. Bennett M.D., Ph.D., Shamia Hoque, Nancy Olivieri, Matthew A. Taylor, David Aboulafia, Courtney Lubaczewski, Andrew C. Bennett, Jay Vemula, Benjamin Schooley, Bartlett J. Witherspoon, Ashley C. Godwin, Paul S. Ray, Marc Fishman, Georgne Herring, Anne Ventrone, Juan Aldaco, William J. Hrushesky, John Restaino, Henrik S. Thomsen, Robert Marx, Et. Al.

Faculty Publications

Background

Methods

Genetic Risk Factors For Alzheimer’S Disease In Racial/Ethnic Minority Populations In The U.S.: A Scoping Review, Lindsey Rubin, Lucy Annang Ingram Phd, Nicholas V. Resciniti, Brianna Ashford-Carroll, Katherine Henrietta Leith, Aubrey Rose, Stephanie Ureña, Quentin Mccollum, Daniela B. Friedman

Faculty Publications

As the United States (U.S.) population rapidly ages, the incidence of Alzheimer's Disease and Related Dementias (ADRDs) is rising, with racial/ethnic minorities affected at disproportionate rates. Much research has been undertaken to test, sequence, and analyze genetic risk factors for ADRDs in Caucasian populations, but comparatively little has been done with racial/ethnic minority populations. We conducted a scoping review to examine the nature and extent of the research that has been published about the genetic factors of ADRDs among racial/ethnic minorities in the U.S. Using an established scoping review methodological framework, we searched electronic databases for articles describing peer-reviewed empirical …

Restriction Of Access To Deep Brain Stimulation For Refractory Ocd: Failure To Apply The Federal Parity Act, Rachel Davis, James Giordano, D Brian Hufford, Sameer A. Sheth, Peter Warnke, Alik S. Widge, R Mark Richardson, Joshua M. Rosenow, Peter Justin Rossi, Eric A. Storch, Helena Winston, Joanne Zboyan, Darin D. Dougherty, Kelly D. Foote, Wayne K. Goodman, Nicole C. Mclaughlin, Steven Ojemann, Steven Rasmussen, Aviva Abosch, Michael S. Okun

Faculty Publications

No abstract provided.

Back Vowel Dynamics And Distinctions In Southern American English, Joseph A. Stanley, Margaret E. L. Renwick, Katherine Ireland Kuiper, Rachel M. Olen

Faculty Publications

Southern American English is spoken in a large geographic region in the United States. Its characteristics include back-vowel fronting (e.g., in goose, foot, and goat), which has been ongoing since the mid-nineteenth century; meanwhile, the low back vowels (in lot and thought) have recently merged in some areas. We investigate these five vowels in the Digital Archive of Southern Speech, a legacy corpus of linguistic interviews with sixty-four speakers born 1886-1956. We extracted 89,367 vowel tokens and used generalized additive mixed-effects models to test for socially-driven changes to both their relative phonetic placements and the shapes of their formant trajectories. …

Mitigating The Security Intention-Behavior Gap: The Moderating Role Of Required Effort On The Intention-Behavior Relationship, Jeffrey L. Jenkins, Alexandra Durcikova, Jay F. Nunamaker Jr.

Faculty Publications

Although users often express strong positive intentions to follow security policies, these positive intentions fail to consistently translate to behavior. In a security setting, the inconsistency between intentions and behavior—termed the intention-behavior gap—is particularly troublesome, as a single failure to enact positive security intentions may make a system vulnerable. We address a need in security compliance literature to better understand the intention-behavior gap by explaining how an omnipresent competing intention—the user’s desire to minimize required effort—negatively moderates the relationship between positive intentions and actual security behavior. Moreover, we posit that this moderating effect is not accounted for in extant theories …

Bridging The Informal And Formal Learning Spaces With Whatsapp, Tutaleni I. Asino, Nandita Gurjar, Perien Boer

Faculty Publications

When it comes to digital-based learning, the question of engagement and presence is often focused on online learning involving traditional computing devices such as desktop computers or laptops. However, in areas where mobile devices are the most widely used computing technology, engagement and interaction between teachers and students looks different. In many parts of the world, interactions between individuals takes place through mobile texting applications to bridge formal and informal learning spaces.

One of the most popular mobile tools is WhatsApp, a free cross-platform mobile application that allows users to make calls (voice) and send messages (text). The app averages …

Social Emotional Learning And The National Core Arts Standards: A Cross-Disciplinary Analysis Of Policy And Practices, Mark Graham, Matt Omasta, Stephanie L. Milling, Elizabeth Murray, Amy Peterson Jensen, Johanna J. Siebert

Faculty Publications

Arts education advocates sometimes point to extrinsic benefits of arts learning, including Social Emotional Learning (SEL). This study considers if and how the National Core Arts Standards (NCAS) in dance, media arts, music, theater, and visual art may align with SEL standards adopted by the state of Illinois, upon which other SEL standards have been modeled. A team of arts education experts coded 15,500 intersections of arts standards &SEL goals. They found a great deal of indirect alignment between the NCAS and SEL objectives, but direct alignment was rare. As the types and degrees of alignment varied by discipline, broad …

Don't Call Us, We'll Call You: An Empirical Study Of Caller Behavior Under A Callback Option, Brett A. Hathaway, Seyed Morteza Emadi, Vinayak Deshpande

Faculty Publications

While call centers have recently invested in callback technology, the impact of this innovation on caller behavior and call center performance is not clearly understood. Using call center data from a US commercial bank, we perform an empirical study of the callers' decision-making process in the presence of a callback option. We formulate a structural model of the caller decision-making process, and impute their underlying preferences from the data. Our estimates show that callers experience substantially less discomfort per unit of time while waiting for callbacks than while waiting in queue. However, we also find that, after controlling for expected …

Toward Uncharted Territory Of Cellular Heterogeneity: Advances And Applications Of Single-Cell Rna-Seq, Brandon Lieberman, Meena Kusi, Chia Nung Hung, Chih Wei Chou, Ning He, Yen Yi Ho, Josephine A. Taverna, Tim H.M. Huang, Chun Liang Chen

Faculty Publications

Among single-cell analysis technologies, single-cell RNA-seq (scRNA-seq) has been one of the front runners in technical inventions. Since its induction, scRNA-seq has been well received and undergone many fast-paced technical improvements in cDNA synthesis and amplification, processing and alignment of next generation sequencing reads, differentially expressed gene calling, cell clustering, subpopulation identification, and developmental trajectory prediction. scRNA-seq has been exponentially applied to study global transcriptional profiles in all cell types in humans and animal models, healthy or with diseases, including cancer. Accumulative novel subtypes and rare subpopulations have been discovered as potential underlying mechanisms of stochasticity, differentiation, proliferation, tumorigenesis, and …

A Method For Cultivation, Fractionation, And Metal Determination To Evaluate Metal Removal By The Combination Of Nps And Bacteria, Xiufeng Cao, Liang Xu, Alan W. Decho, Jamie Lead

Faculty Publications

Metals being released into the environment are posing an increasing risk to both environments and public health. Developing improved approaches to remove these metals from the environment is urgent. A current publication discovered that metal bioremediation was significantly improved by nanoparticles (NPs), and the remediation duration was shortened. However, there is no relevant method for the preparation and evaluation of this novel idea. Hence, we developed this method for bacteria -EPS (Extracellular Polymeric Substances) cultivation, bacteria sub-cellular fractionation, and metal determinations in cultivating solution, EPS and different fractions of bacteria to evaluate metal removal by the combination of NPs and …

The Corn Parade: Orr Fisher's Wacky Wpa Mural, Roy R. Behrens

Faculty Publications

No abstract provided.

Improving Teacher Evaluation By Walking The Talk Of Standards-Based Grading: Communicating Educator Growth Using Proficiency Scales, Chad Lang, Matt Townsley

Faculty Publications

Teachers and school leaders frequently express a disconnect in the purpose and importance of teacher evaluation, particularly as it relates to educator growth. At the same time, some schools are beginning to communicate student growth through a standards-based grading philosophy. One way schools might “walk the talk” of their grading reform efforts designed to communicate student growth is through the use of proficiency scales to prioritize growth in teacher evaluation. This paper describes implications of simultaneously utilizing a growth model for teacher evaluation and a student growth model via standards-based grading.

Implementation Of Brain Breaks® In The Classroom And Its Effects On Attitudes Towards Physical Activity In A Chinese School Setting, Ke Zhou, Sensen He, Yanli Zhou, Biljana Popeska, Garry Kuan, Li Chen, Ming Kai Chin, Magdalena Mo Ching Mok, Christopher R. Edginton, Ian Culpan, J. Larry Durstine

Faculty Publications

This study aimed to examine the effects of three-months of classroom-based Brain Breaks Physical Activity Solution (Brain Breaks®) on attitudes toward physical activity levels of primary school children in Henan Province, China. The participants were 704 children enrolled in grades 3-5 who were randomly assigned to either an experimental or a control group. The experimental group participated in Brain Breaks® video intervention for 3-5 min daily, at low-to-moderate intensity for three consecutive months. The control group resumed their normal routine. The children’s attitudes in both groups towards physical activity (PA) were evaluated using the self-reported Attitudes toward Physical Activity Scale …

Rethinking Sustainability Monitoring In The Arctic By Linking Resilience And Sustainable Development In Socially-Oriented Observations: A Perspective, Tatiana Vlasova, Andrey N. Petrov, Sergey Volkov

Faculty Publications

Monitoring of social-ecological systems dynamics and sustainability is of high importance in a rapidly changing Arctic. The goal of this essay is to discuss and articulate the principles for designing a suitable Arctic sustainability monitoring framework based on the convergence between resilience thinking and sustainable development paradigms. We propose to integrate sustainability monitoring into the socially-oriented observations (SOO) methodologies in order to design Arctic sus-tainability monitoring as a transdisciplinary participatory activity that results in both co-production of sustainability knowledge and building more sustainable and resilient Arctic social-ecological systems by enabling continuous observation and informed decision-making. Special attention is given to …

Photo Identification Laws And Perceptions Of Electoral Fraud, Kyle Endres, Costas Panagopoulos

Faculty Publications

Photo identification (ID) laws are often passed on the premise that they will prevent voter fraud and/or reduce perceptions of electoral fraud. The impact of ID laws on perceptions of electoral fraud remains unsettled and is complicated by widespread confusion about current voting requirements. In the 2017 Virginia election, we fielded an experiment, with an advocacy organization, evaluating the effects of the organization’s outreach campaign. We randomized which registered voters were mailed one of three informational postcards. After the election, we surveyed subjects about electoral integrity and their knowledge about election laws. We find that providing registrants with information on …

Effects Of Exercise On Tests Measuring Attention And Executive Function In Younger And Older Adults, Angela N. Burda, Jennifer Baldwin, Johanna Cravatta, Jody Heetland, Kayla Jacobs, Hannah Merfeld, Jaden Rausch, Mallory Rinnels, Regan Zollman

Faculty Publications

Purpose: This study investigated whether or not performance differed between Young and Older Exercisers and between Young and Older Non-exercisers on the Attention Processing Training-Test (APT-Test), Behavioral Assessment of Dysexecutive Syndrome (BADS), and Functional Assessment of Verbal Reasoning and Executive Strategies (FAVRES). Methods: A total of 119 participants were divided into the following groups: 46 Young Exercisers: (aged 18-40 years), 45 Older Exercisers (aged 60 and older), fourteen Young Non-exercisers, and fourteen Older Non-exercisers. Participants completed the APT-Test, BADS, and FAVRES in a counterbalanced manner. Independent sample t-tests were used to calculate outcomes. Results: Young Exercisers had significantly higher scores …

Balancing Privacy Rights And Surveillance Analytics: A Decision Process Guide, Daniel J. Power, Ciara Heavin, Yvonne O’Connor

Faculty Publications

The right to privacy has been discussed by scholars in multiple disciplines, yet privacy issues are increasing due to technological advances and lower costs for organisations to adopt smart surveillance. Given the potential for misuse, it seems prudent for stakeholders to critically evaluate Surveillance Analytics (SA) innovations. To assist in balancing the issues arising from SA adoption and the implications for privacy, we review key terms and ethical frameworks. Further, we prescribe a two-by-two Surveillance, Privacy, and Ethical Decision (SPED) Process Guide. SPED recommends the use of one or more of three ethical frameworks, Consequence, Duty, and Virtue. The vertical …

An Estimate Of The Pitting Strength Of Steel Materials, Edward E. Osakue, Lucky Anetor, Kendall Harris

Faculty Publications

A single expression for estimating the nominal pitting strength of steel materials, based on surface hardness, is developed from first principles for a reliability of 99% at 107 load cycles. It requires the hardness values to be measured in Vicker’s hardness scale. The expression may be used for any steel material processed by hot rolling, cold drawing, quenching and tempering or case-hardening. The formulation incorporates a nominal design factor at 99% reliability which is estimated from a probabilistic model based on the lognormal probability density function. Pitting strength estimates from the expression are compared with those of American Gear Manufacturers …

Responding To The Call: Building A Training Program To Diversify The Academy In Alzheimer’S Disease Research, Lucy Annang Ingram Phd, Marvella E. Ford, Christiana L. Johnson, Brianna Ashford-Carroll, Quentin Mccollum, Daniela B. Friedman, Sue E. Levkoff

Faculty Publications

Alzheimer's disease and related dementias (ADRD) are at the forefront of the United States (US) public health agenda due to their tremendous human and financial burden. Further, disproportionately high ADRD rates among racial/ethnic minorities require incorporating the unique perspectives of racially and ethnically diverse scientists, which will necessitate diversifying the scientific workforce that investigates disparities in aging. The purpose of this paper is to describe the training and mentorship initiatives of the National Institute on Aging (NIA)-funded Carolina Center on Alzheimer's Disease and Minority Research, emphasizing lessons learned from our engagement with underrepresented minority and minoritized (URM) Scientists. We highlight …

Kinetics Study Of The Hydrodeoxygenation Of Xylitol Over A ReoX-Pd/Ceo2 Catalyst, Blake Macqueen, Michael Royko, Bradie S. Crandall, Andreas Heyden, Yomaira J. Pagán-Torres, Jochen A. Lauterbach

Faculty Publications

In this study, we elucidate the reaction kinetics for the simultaneous hydrodeoxygenation of xylitol to 1,2-dideoxypentitol and 1,2,5-pentanetriol over a ReOx-Pd/CeO2 (2.0 weight% Re, 0.30 weight% Pd) catalyst. The reaction was determined to be a zero-order reaction with respect to xylitol. The activation energy was elucidated through an Arrhenius relationship as well as non-Arrhenius kinetics. The Arrhenius relationship was investigated at 150–170◦ C and a constant H2 pressure of 10 bar resulting in an activation energy of 48.7 ± 10.5 kJ/mol. The investigation of non-Arrhenius kinetics was conducted at 120–170◦ C and a sub-Arrhenius relation was elucidated with activation energy …

Nutritional Approach For Increasing Public Health During Pandemic Of Covid-19: A Comprehensive Review Of Antiviral Nutrients And Nutraceuticals, Vahideh Ebrahimzadeh-Attari, Ghodratollah Panahi, James R. Hébert Scd, Alireza Ostadrahimi, Maryam Saghafi-Asl, Neda Lotfi-Yaghin, Behzad Baradaran

Faculty Publications

Background: The novel coronavirus (COVID-19) is considered as the most life-threatening pandemic disease during the last decade. The individual nutritional status, though usually ignored in the management of COVID-19, plays a critical role in the immune function and pathogenesis of infection. Accordingly, the present review article aimed to report the effects of nutrients and nutraceuticals on respiratory viral infections including COVID-19, with a focus on their mechanisms of action.

Methods: Studies were identified via systematic searches of the databases including PubMed/ MEDLINE, ScienceDirect, Scopus, and Google Scholar from 2000 until April 2020, using keywords. All relevant clinical and experimental studies …

Tutorial: Mapping Your Institutional Curriculum To The Is2020 Competency Model, Paul M. Leidig, Hannu Salmela, Greg Anderson, Jeff Babb, Venky Shankararaman, Raja Sooriamurthi, Mark Thouin

Faculty Publications

The Association of Computing Machinery (ACM) and the Association for Information Systems (AIS), two global professional and academic societies with a stake in Information Systems (IS) education, engaged in a project to revise the Information Systems Curriculum for bachelor’s degrees. This tutorial introduces the recently approved IS2020 competency guidelines, hence serving to disseminate the IS competency model and related guidelines within the SIGED community. This tutorial session should be of interest to all IS academics, especially faculty developing college-level curricula in Information Systems.

Are Monthly Market Returns Predictable?, Jussi Keppo, Tyler Shumway, Daniel Weagley

Faculty Publications

We document significant persistence in the market timing performance of active individual investors, suggesting that some investors are skilled at timing. Using data on all trades by active Finnish individual investors over almost 15 years, we also show that the net purchases of skilled versus unskilled investors predict monthly market returns. Our results lend credibility to the view that market returns are predictable, without having to specify which variables active investors use to successfully time the market.

Indigenous-Led Grassroots Engagements With Oil Pipelines In The U.S. And Russia: The Nodapl And Komi Movements, Maria S. Tysiachniouk, Leah S. Horowitz, Varvara V. Korkina, Andrey N. Petrov

Faculty Publications

Networks play an important role in the Indigenous rights movement’s strategies and in Indigenous groups’ engagements with industry actors, the State, and NGOs. We seek to extend the concept of Governance Generating Networks (GGN) to incorporate Indigenous grassroots movements, and evaluate multiscale interactions and processes of network-generated governance across scales. We compare the NoDAPL movement led by the Standing Rock Sioux Tribe in the U.S. with grassroots Indigenous-environmentalist networks of water defenders in the Komi Republic, Russia. These GGNs emerged to protest oil pipelines within two contrasting sociopolitical systems, yet demonstrate substantial similarities in respect to local grievances and global …

Historical Christological Heresies, Trevor O'Reggio

Faculty Publications

No abstract provided.

Reform Through Resignation: Why Chief Justice Roberts Should Resign (In 2023), Scott P. Bloomberg

Faculty Publications

Many proponents of reforming the Supreme Court have expressed support for adopting a system of eighteen-year staggered term limits. These proposals, however, are hobbled by constitutional constraints: Amending the Constitution to implement term limits is highly implausible and implementing term limits through statute is likely unconstitutional. This Essay offers an approach to implementing term limits that avoids these constitutional constraints. Just as President Washington was able to establish a de facto Presidential term limit by not seeking a third term in office, Chief Justice Roberts is uniquely positioned to establish a new norm of serving eighteen-year terms on the Court. …

Wealth Transfer Tax Planning After The Tax Cuts And Jobs Act, Jeffrey A. Maine, John A. Miller

Faculty Publications

On December 17, 2017, Congress passed the Tax Cuts and Jobs Act (TCJA). Among its many impacts, the TCJA increased the inflation-adjusted estate tax basic exclusion amount to $10,000,000 on a temporary basis. This has dramatic implications for many existing and future estate plans, including a major crossover impact on income tax planning. In this Article, we explain the operation of the federal wealth transfer taxes (the estate tax, the gift tax, and the generation skipping transfer tax) in the wake of the TCJA and dissect the basic tax planning techniques for wealth transmission. The overall design of this Article …

Environmental Indifference, Anthony L. Moffa

Faculty Publications

An incarcerated American underclass, disproportionately comprised of minority citizens, has been compelled to live in an unconstitutionally polluted environment. Exposure to radon gas in indoor air is just one example of that pollution. Fortunately, the legal effort to address that particular condition of confinement has already begun; the theoretical and practical discussion in this work strives to both highlight the importance of the issue and inform the doctrinal development. The Eighth Amendment precedent created on the specific issue of radon exposure will very likely control the courts’ treatment of other environmental harms ignored by prison officials. This work, using radon …

Strength In Numbers (Of Words): Empirical Analysis Of Preambles And Public Comments, Anthony L. Moffa

Faculty Publications

The empirical observation of a four-decades-long trend towards longer and longer federal agency rulemakings laid the foundation for this series of studies and associated law review articles. The second in that series, this work will add necessary data, test important hypotheses, and draw new conclusions to guide policymakers. Any serious observer of the Federal Register recognizes that different sections of a rulemaking serve different purposes. And agencies have historically utilized one section in particular to insulate their rules from judicial vacation or remand – the “concise general statement of basis and purpose.” Thus, this new study will collect and analyze …

Increasing Cybersecurity Career Interest Through Playable Case Studies, Justin Scott Giboney, Jason K. Mcdonald, Jonathan Balzotti, Derek L. Hansen, Desiree M. Winters, Elizabeth Bonsignore

Faculty Publications

In this paper we introduce an approach to cybersecurity education and helping students develop professional understanding in the form of a Playable Case Study (PCS), a form of educational simulation that draws on affordances of the broader educational simulation genre, case study instruction, and educational Alternate Reality Games (or ARGs). A PCS is an interactive simulation that allows students to “play” through an authentic scenario (case study) as a member of a professional team. We report our findings over a multi-year study of a PCS called Cybermatics, with data from 111 students from two different U.S. universities who interacted with …