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A Review Of Methods Of Assessing Preference For Social Stimuli, Samuel L. Morris, Madison L. Gallagher, Alva E. Allen Apr 2023

A Review Of Methods Of Assessing Preference For Social Stimuli, Samuel L. Morris, Madison L. Gallagher, Alva E. Allen

Faculty Publications

Research on preference and reinforcer assessments has historically focused on the evaluation of edible and leisure reinforcers, but the identification and use of individualized social reinforcers may be beneficial for several reasons. Recently, many studies have evaluated methods of assessing preference for social stimuli. The procedures and outcomes across these studies have varied greatly, and the current state of evidence for methods of assessing preference for social stimuli remains unclear. Thus, we conducted a review to synthesize all previous research in this area, evaluate the evidence for the utility of this general methodology, and identify factors that may influence its …

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The Impact Of Covid-19, Mental Health Distress, And School-Based Sociocultural Protective Factors Among Elementary-Aged Children And Their Caregivers, Aijah K.B. Goodwin, Anthony J. Roberson, Ar’Reon Watson, Grace L. Chen, Anna C.J. Long Apr 2023

The Impact Of Covid-19, Mental Health Distress, And School-Based Sociocultural Protective Factors Among Elementary-Aged Children And Their Caregivers, Aijah K.B. Goodwin, Anthony J. Roberson, Ar’Reon Watson, Grace L. Chen, Anna C.J. Long

Faculty Publications

Given the individual and systemic stress endured by children and families during the COVID-19 pandemic, research examining culturally responsive school experiences and supports to enhance resilience is critical. This study examined the relationship between caregivers’ perceptions of COVID-19 impact, mental health distress among children and caregivers, and school-based sociocultural protective factors, including culturally responsive practices in schools and the relationships between teachers and caregivers, concurrently and longitudinally. Data were collected from caregivers of elementary-aged children at two-time points from March to April 2020 (N = 174) and one year later in 2021 (N = 114). Regression analyses revealed that COVID-19 …

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Environmental Attitudes And Fertility Desires Among Us Adolescents From 2005–2019, Heather M. Rackin, Alison Gemmill, Caroline Sten Hartnett Apr 2023

Environmental Attitudes And Fertility Desires Among Us Adolescents From 2005–2019, Heather M. Rackin, Alison Gemmill, Caroline Sten Hartnett

Faculty Publications

Objective: This brief report examines links between environmental attitudes and fertility desires over time in the United States. Background: To understand fertility decision making, it is important to identify factors that influence fertility desires. Concerns about environmental problems may be associated with lower desired fertility, especially in recent cohorts transitioning to adulthood. Youth may feel that having one less child can reduce their “carbon footprint” or may be unwilling to bring children into an uncertain and difficult future due to climate change. Method: Data are from 12th graders in the Monitoring the Future study (2005–2019; N = 34,104). Regression is …

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Total Daily Energy Expenditure Has Declined Over The Past Three Decades Due To Declining Basal Expenditure, Not Reduced Activity Expenditure, John R. Speakman, Jasper M.A. De Jong, Srishti Sinha, Klaas R. Westerterp, Yosuke Yamada, Hiroyuki Sagayama, Philip N. Ainslie, Liam J. Anderson, Lenore Arab, Kweku Bedu-Addo, Stephane Blanc, Alberto G. Bonomi, Pascal Bovet, Soren Brage, Maciej S. Buchowski, Nancy F. Butte, Stefan G.J.A. Camps, Jamie A. Cooper, Richard Cooper, Sai Krupa Das, Peter S.W. Davies, Lara R. Dugas, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W. Fudge, Melanie Gillingham, Santu Ghosh, Annelies H. Goris, Michael Gurven, Lewis G. Halsey, Catherine Hambly, Hinke H. Haisma Apr 2023

Total Daily Energy Expenditure Has Declined Over The Past Three Decades Due To Declining Basal Expenditure, Not Reduced Activity Expenditure, John R. Speakman, Jasper M.A. De Jong, Srishti Sinha, Klaas R. Westerterp, Yosuke Yamada, Hiroyuki Sagayama, Philip N. Ainslie, Liam J. Anderson, Lenore Arab, Kweku Bedu-Addo, Stephane Blanc, Alberto G. Bonomi, Pascal Bovet, Soren Brage, Maciej S. Buchowski, Nancy F. Butte, Stefan G.J.A. Camps, Jamie A. Cooper, Richard Cooper, Sai Krupa Das, Peter S.W. Davies, Lara R. Dugas, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W. Fudge, Melanie Gillingham, Santu Ghosh, Annelies H. Goris, Michael Gurven, Lewis G. Halsey, Catherine Hambly, Hinke H. Haisma

Faculty Publications

Obesity is caused by a prolonged positive energy balance1,2. Whether reduced energy expenditure stemming from reduced activity levels contributes is debated3,4. Here we show that in both sexes, total energy expenditure (TEE) adjusted for body composition and age declined since the late 1980s, while adjusted activity energy expenditure increased over time. We use the International Atomic Energy Agency Doubly Labelled Water database on energy expenditure of adults in the United States and Europe (n = 4,799) to explore patterns in total (TEE: n = 4,799), basal (BEE: n = 1,432) and physical activity energy expenditure (n = 1,432) over time. …

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Consumers’ Acceptance, Emotions, And Responsiveness To Informational Cues For Air-Fried Catfish (Ictalurus Punctatus) Skin Chips, Silvia Murillo, Ryan Ardoin, Witoon Prinyawiwatkul Apr 2023

Consumers’ Acceptance, Emotions, And Responsiveness To Informational Cues For Air-Fried Catfish (Ictalurus Punctatus) Skin Chips, Silvia Murillo, Ryan Ardoin, Witoon Prinyawiwatkul

Faculty Publications

Catfish (Ictalurus punctatus) skins, as filleting byproduct, were developed into a crispy snack food via air-frying. Consumers rated catfish skin chips (CSC) across sensory modalities (9-point hedonic scales, a just-about-right scale, and “yes/no” for purchase intent, PI) for Plain-, Lemon & Pepper-, and Barbecue-flavored samples during two consumer studies (N = 115 each). Paprika- flavored CSC were excluded from Study 2 due to inferior acceptance and emotional ratings. CSC-elicited emotions were evaluated using a 25-term lexicon with CATA (Check-All-That-Apply) scaling (Study 1) and refined with an abbreviated lexicon containing food-evoked sensation-seeking emotions (5-point intensity scale). The two consumer studies differed …

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Stable Isotope Tracing Reveals An Altered Fate Of Glucose In N-Acetyltransferase 1 Knockout Breast Cancer Cells, James T.F. Wise, Xinmin Yin, Xipeng Ma, Xiang Zhang, David W. Hein Apr 2023

Stable Isotope Tracing Reveals An Altered Fate Of Glucose In N-Acetyltransferase 1 Knockout Breast Cancer Cells, James T.F. Wise, Xinmin Yin, Xipeng Ma, Xiang Zhang, David W. Hein

Faculty Publications

Breast cancer is one of the leading causes of cancer death. Recent studies found that arylamine N-acetyltransferase 1 (NAT1) is frequently upregulated in breast cancer, further suggesting NAT1 could be a potential therapeutic target for breast cancer. Previous publications have established that NAT1 knockout (KO) in breast cancer cell lines leads to growth reduction both in vitro and in vivo and metabolic changes. These reports suggest that NAT1 contributes to the energy metabolism of breast cancer cells. Proteomic analysis and non-targeted metabolomics suggested that NAT1 KO may change the fate of glucose as it relates to the TCA/KREB cycle of …

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Measurement Of The Neutron Cross Section On Argon Between 95 And 720 Mev, S. Martynenko, B. Bhandari, J. Bian, K. Bilton, C. Callahan, J. Chaves, H. Chen, D. Cline, R. L. Cooper, D. L. Danielson, J. Danielson, N. Dokania, S. Elliott, S. Fernandes, S. Gardiner, G. Garvey, V. Gehman, F. Giuliani, S. Glavin, M. Gold, C. Grant, E. Guardincerri, T. Haines, A. Higuera, J. Y. Ji, R. Kadel, N. Kamp, A. Karlin, W. Ketchum, L. W. Koerner, D. Lee, K. Lee, Q. Liu Apr 2023

Measurement Of The Neutron Cross Section On Argon Between 95 And 720 Mev, S. Martynenko, B. Bhandari, J. Bian, K. Bilton, C. Callahan, J. Chaves, H. Chen, D. Cline, R. L. Cooper, D. L. Danielson, J. Danielson, N. Dokania, S. Elliott, S. Fernandes, S. Gardiner, G. Garvey, V. Gehman, F. Giuliani, S. Glavin, M. Gold, C. Grant, E. Guardincerri, T. Haines, A. Higuera, J. Y. Ji, R. Kadel, N. Kamp, A. Karlin, W. Ketchum, L. W. Koerner, D. Lee, K. Lee, Q. Liu

Faculty Publications

We report an extended measurement of the neutron cross section on argon in the energy range of 95-720 MeV. The measurement was obtained with a 4.3-hour exposure of the Mini-CAPTAIN detector to the WNR/LANSCE beam at LANL. Compared to an earlier analysis of the same data, this extended analysis includes a reassessment of systematic uncertainties, in particular related to unused wires in the upstream part of the detector. Using this information we doubled the fiducial volume in the experiment and increased the statistics by a factor of 2.4. We also shifted the analysis from energy bins to time-of-flight bins. This …

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Evaluation Of Alternative Colony Hybridization Methods For Pathogenic Vibrios, Andrew M. Schwartz, Haley A. Marcotte, Crystal N. Johnson Apr 2023

Evaluation Of Alternative Colony Hybridization Methods For Pathogenic Vibrios, Andrew M. Schwartz, Haley A. Marcotte, Crystal N. Johnson

Faculty Publications

Vibrios, such as Vibrio parahaemolyticus, are naturally occurring halophilic bacteria that are a major cause of foodborne illness. Because of their autochthonous nature, managing vibrio levels in marine and estuarine environments is impossible. Instead, it is crucial to reliably enumerate their abundance to minimize human exposure. One method of achieving this is the direct plating/colony hybridization (DP/CH) method, which has been used to efficiently quantify pathogenic vibrios in oysters and other seafood products. Although successful, the method relies on proprietary resources. We examined alternative approaches, assessed the influence of the reagent suppliers’ source on enumeration accuracy, and made experimental adjustments …

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The Fermi-Lat Lightcurve Repository, S. Abdollahi, M. Ajello, L. Baldini, J. Ballet, D. Bastieri, J. Becerra Gonzalez, R. Bellazzini, A. Berretta, E. Bissaldi, R. Bonino, A. Brill, P. Bruel, E. Burns, S. Buson, R. A. Cameron, R. Caputo, P. A. Caraveo, N. Cibrario, S. Ciprini, P. Cristarella Orestano, M. Crnogorcevic, S. Cutini, F. D’Ammando, S. De Gaetano, S. W. Digel, N. Di Lalla, L. Di Venere, A. Domínguez, V. Fallah Ramazani, S. J. Fegan, E. C. Ferrara, A. Fiori, H. Fleischhack Apr 2023

The Fermi-Lat Lightcurve Repository, S. Abdollahi, M. Ajello, L. Baldini, J. Ballet, D. Bastieri, J. Becerra Gonzalez, R. Bellazzini, A. Berretta, E. Bissaldi, R. Bonino, A. Brill, P. Bruel, E. Burns, S. Buson, R. A. Cameron, R. Caputo, P. A. Caraveo, N. Cibrario, S. Ciprini, P. Cristarella Orestano, M. Crnogorcevic, S. Cutini, F. D’Ammando, S. De Gaetano, S. W. Digel, N. Di Lalla, L. Di Venere, A. Domínguez, V. Fallah Ramazani, S. J. Fegan, E. C. Ferrara, A. Fiori, H. Fleischhack

Faculty Publications

The Fermi Large Area Telescope (LAT) lightcurve repository (LCR) is a publicly available, continually updated library of gamma-ray lightcurves of variable Fermi-LAT sources generated over multiple timescales. The Fermi-LAT LCR aims to provide publication-quality lightcurves binned on timescales of 3, 7, and 30 days for 1525 sources deemed variable in the source catalog of the first 10 yr of Fermi-LAT observations. The repository consists of lightcurves generated through full likelihood analyses that model the sources and the surrounding region, providing fluxes and photon indices for each time bin. The LCR is intended as a resource for the time-domain and multimessenger …

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Minimal Volume Entropy Of Raag's, Matthew Haulmark, Kevin Schreve Apr 2023

Minimal Volume Entropy Of Raag's, Matthew Haulmark, Kevin Schreve

Faculty Publications

Bregman and Clay recently characterized which right-angled Artin groups with geometric dimension 2 have vanishing minimal volume entropy. In this note, we extend this characterization to higher dimensions.

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Moa-2020-Blg-208lb: Cool Sub-Saturn-Mass Planet Within Predicted Desert, Greg Olmschenk, David P. Bennett, Ian A. Bond, Weicheng Zang, Youn Kil Jung, Jennifer C. Yee, Etienne Bachelet, Fumio Abe, Richard K. Barry, Aparna Bhattacharya, Hirosane Fujii, Akihiko Fukui, Yuki Hirao, Stela Ishitani Silva, Yoshitaka Itow, Rintaro Kirikawa, Iona Kondo, Naoki Koshimoto, Yutaka Matsubara, Sho Matsumoto, Shota Miyazaki, Brandon Munford, Yasushi Muraki, Arisa Okamura, Clément Ranc, Nicholas J. Rattenbury, Yuki Satoh, Takahiro Sumi, Daisuke Suzuki, Taiga Toda, Paul J. Tristram, Aikaterini Vandorou, Hibiki Yama Apr 2023

Moa-2020-Blg-208lb: Cool Sub-Saturn-Mass Planet Within Predicted Desert, Greg Olmschenk, David P. Bennett, Ian A. Bond, Weicheng Zang, Youn Kil Jung, Jennifer C. Yee, Etienne Bachelet, Fumio Abe, Richard K. Barry, Aparna Bhattacharya, Hirosane Fujii, Akihiko Fukui, Yuki Hirao, Stela Ishitani Silva, Yoshitaka Itow, Rintaro Kirikawa, Iona Kondo, Naoki Koshimoto, Yutaka Matsubara, Sho Matsumoto, Shota Miyazaki, Brandon Munford, Yasushi Muraki, Arisa Okamura, Clément Ranc, Nicholas J. Rattenbury, Yuki Satoh, Takahiro Sumi, Daisuke Suzuki, Taiga Toda, Paul J. Tristram, Aikaterini Vandorou, Hibiki Yama

Faculty Publications

We analyze the MOA-2020-BLG-208 gravitational microlensing event and present the discovery and characterization of a new planet, MOA-2020-BLG-208Lb, with an estimated sub-Saturn mass. With a mass ratio q=3.17-0.26+0.28×10-4, the planet lies near the peak of the mass-ratio function derived by the MOA collaboration and near the edge of expected sample sensitivity. For these estimates we provide results using two mass-law priors: one assuming that all stars have an equal planet-hosting probability, and the other assuming that planets are more likely to orbit around more massive stars. In the first scenario, we estimate that the lens system is likely to be …

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Kepler K2 Campaign 9 – Ii. First Space-Based Discovery Of An Exoplanet Using Microlensing, D. Specht, R. Poleski, M. T. Penny, E. Kerins, I. Mcdonald, Lee Chung-Uk, A. Udalski, I. A. Bond, Y. Shvartzvald, Weicheng Zang, R. A. Street, D. W. Hogg, B. S. Gaudi, T. Barclay, G. Barentsen, S. B. Howell, F. Mullally, C. B. Henderson, S. T. Bryson, D. A. Caldwell, M. R. Haas, J. E. Van Cleve, K. Larson, K. Mccalmont, C. Peterson, D. Putnam, S. Ross, M. Packard, L. Reedy, Michael D. Albrow, Chung Sun-Ju, Youn Kil Jung, Andrew Gould Apr 2023

Kepler K2 Campaign 9 – Ii. First Space-Based Discovery Of An Exoplanet Using Microlensing, D. Specht, R. Poleski, M. T. Penny, E. Kerins, I. Mcdonald, Lee Chung-Uk, A. Udalski, I. A. Bond, Y. Shvartzvald, Weicheng Zang, R. A. Street, D. W. Hogg, B. S. Gaudi, T. Barclay, G. Barentsen, S. B. Howell, F. Mullally, C. B. Henderson, S. T. Bryson, D. A. Caldwell, M. R. Haas, J. E. Van Cleve, K. Larson, K. Mccalmont, C. Peterson, D. Putnam, S. Ross, M. Packard, L. Reedy, Michael D. Albrow, Chung Sun-Ju, Youn Kil Jung, Andrew Gould

Faculty Publications

We present K2-2016-BLG-0005Lb, a densely sampled, planetary binary caustic-crossing microlensing event found from a blind search of data gathered from Campaign 9 of the Kepler K2 mission (K2C9). K2-2016-BLG-0005Lb is the first bound microlensing exoplanet discovered from space-based data. The event has caustic entry and exit points that are resolved in the K2C9 data, enabling the lens-source relative proper motion to be measured. We have fitted a binary microlens model to the Kepler data and to simultaneous observations from multiple ground-based surveys. Whilst the ground-based data only sparsely sample the binary caustic, they provide a clear detection of parallax that …

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Application Of The Variational Autoencoder To Detect The Critical Points Of The Anisotropic Ising Model, Anshumitra Baul, Nicholas Walker, Juana Moreno, Ka Ming Tam Apr 2023

Application Of The Variational Autoencoder To Detect The Critical Points Of The Anisotropic Ising Model, Anshumitra Baul, Nicholas Walker, Juana Moreno, Ka Ming Tam

Faculty Publications

We generalize the previous study on the application of variational autoencoders to the two-dimensional Ising model to a system with anisotropy. Due to the self-duality property of the system, the critical points can be located exactly for the entire range of anisotropic coupling. This presents an excellent test bed for the validity of using a variational autoencoder to characterize an anisotropic classical model. We reproduce the phase diagram for a wide range of anisotropic couplings and temperatures via a variational autoencoder without the explicit construction of an order parameter. Considering that the partition function of (d+1)-dimensional anisotropic models can be …

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Blow-Up Criteria Below Scaling For Defocusing Energy-Supercritical Nls And Quantitative Global Scattering Bounds, Aynur Bulut Apr 2023

Blow-Up Criteria Below Scaling For Defocusing Energy-Supercritical Nls And Quantitative Global Scattering Bounds, Aynur Bulut

Faculty Publications

We establish quantitative blow-up criteria below the scaling threshold for radially symmetric solutions to the defocusing nonlinear Schrödinger equation with nonlinearity |u|6 u. This provides to our knowledge the first generic results distinguishing potential blow-up solutions of the defocusing equation from many of the known examples of blow-up in the focusing case. Our main tool is a quantitative version of a result showing that uniform bounds on L2-based critical Sobolev norms imply scattering estimates. As another application of our techniques, we establish a variant which allows for slow growth in the critical norm. We show that if …

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Ecophysiology And Genomics Of The Brackish Water Adapted Sar11 Subclade Iiia, V. Celeste Lanclos, Anna N. Rasmussen, Conner Y. Kojima, Chuankai Cheng, Michael W. Henson, Brant C. Faircloth, Christopher A. Francis, J. Cameron Thrash Apr 2023

Ecophysiology And Genomics Of The Brackish Water Adapted Sar11 Subclade Iiia, V. Celeste Lanclos, Anna N. Rasmussen, Conner Y. Kojima, Chuankai Cheng, Michael W. Henson, Brant C. Faircloth, Christopher A. Francis, J. Cameron Thrash

Faculty Publications

The Order Pelagibacterales (SAR11) is the most abundant group of heterotrophic bacterioplankton in global oceans and comprises multiple subclades with unique spatiotemporal distributions. Subclade IIIa is the primary SAR11 group in brackish waters and shares a common ancestor with the dominant freshwater IIIb (LD12) subclade. Despite its dominance in brackish environments, subclade IIIa lacks systematic genomic or ecological studies. Here, we combine closed genomes from new IIIa isolates, new IIIa MAGS from San Francisco Bay (SFB), and 460 highly complete publicly available SAR11 genomes for the most comprehensive pangenomic study of subclade IIIa to date. Subclade IIIa represents a taxonomic …

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Mapping And Identification Of Molecular Markers For The Pc96 Gene Conferring Resistance To Crown Rust In Oat, Sidrat Abdullah, Gordon Tyler, Belayneh Admassu Yimer, Edyta Paczos-Grzęda, Stephen A. Harrison, James G. Menzies, Kathy Esvelt Klos Apr 2023

Mapping And Identification Of Molecular Markers For The Pc96 Gene Conferring Resistance To Crown Rust In Oat, Sidrat Abdullah, Gordon Tyler, Belayneh Admassu Yimer, Edyta Paczos-Grzęda, Stephen A. Harrison, James G. Menzies, Kathy Esvelt Klos

Faculty Publications

Oat crown rust caused by Puccinia coronata f. sp. avenae P. Syd. & Syd (Pca) is a major constraint to oat (Avena sativa L.) production in many parts of the globe. The objectives of this study were to locate Pc96 on the oat consensus map and to develop SNP markers linked to Pc96 for use in marker-assisted selection. SNP loci linked to the crown rust resistance gene Pc96 were identified by linkage analysis and PACE assays were developed for marker-assisted selection in breeding programs. Pc96 is a race-specific crown rust resistance gene originating from cultivated oat that has been deployed …

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Attributes Of Culture Bacteria As Influenced By Ingredients That Help Treat Leaky Gut, Ricardo S. Aleman, David Paz, Roberto Cedillos, Miguel Tabora, Douglas W. Olson, Kayanush Aryana Apr 2023

Attributes Of Culture Bacteria As Influenced By Ingredients That Help Treat Leaky Gut, Ricardo S. Aleman, David Paz, Roberto Cedillos, Miguel Tabora, Douglas W. Olson, Kayanush Aryana

Faculty Publications

Consumers are becoming aware of functional ingredients such as medicinal herbs, polyphenols, mushrooms, amino acids, proteins, and probiotics more than ever before. Like yogurt and its probiotics, L-glutamine, quercetin, slippery elm bark, marshmallow root, N-acetyl-D-glucosamine, licorice root, maitake mushrooms, and zinc orotate have demonstrated health benefits through gut microbiota. The impact of these ingredients on yogurt starter culture bacteria characteristics is not well known. The objective of this study was to determine the influence of these ingredients on the probiotic characteristics, tolerance to gastric juices and lysozyme, protease activity, and viability of Streptococcus thermophilus STI-06 and Lactobacillus bulgaricus LB-12. Acid …

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Genome-Wide Association Analysis Of Hyperspectral Reflectance Data To Dissect The Genetic Architecture Of Growth-Related Traits In Maize Under Plant Growth-Promoting Bacteria Inoculation, Rafael Massahiro Yassue, Giovanni Galli, Chun Peng James Chen, Roberto Fritsche-Neto, Gota Morota Apr 2023

Genome-Wide Association Analysis Of Hyperspectral Reflectance Data To Dissect The Genetic Architecture Of Growth-Related Traits In Maize Under Plant Growth-Promoting Bacteria Inoculation, Rafael Massahiro Yassue, Giovanni Galli, Chun Peng James Chen, Roberto Fritsche-Neto, Gota Morota

Faculty Publications

Plant growth-promoting bacteria (PGPB) may be of use for increasing crop yield and plant resilience to biotic and abiotic stressors. Using hyperspectral reflectance data to assess growth-related traits may shed light on the underlying genetics as such data can help assess biochemical and physiological traits. This study aimed to integrate hyperspectral reflectance data with genome-wide association analyses to examine maize growth-related traits under PGPB inoculation. A total of 360 inbred maize lines with 13,826 single nucleotide polymorphisms (SNPs) were evaluated with and without PGPB inoculation; 150 hyperspectral wavelength reflectances at 386–1021 nm and 131 hyperspectral indices were used in the …

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Neutron Interferometry Using A Single Modulated Phase Grating, I. Hidrovo, J. Dey, H. Meyer, D. S. Hussey, N. N. Klimov, L. G. Butler, K. Ham, W. Newhauser Apr 2023

Neutron Interferometry Using A Single Modulated Phase Grating, I. Hidrovo, J. Dey, H. Meyer, D. S. Hussey, N. N. Klimov, L. G. Butler, K. Ham, W. Newhauser

Faculty Publications

Neutron grating interferometry provides information on phase and small-angle scatter in addition to attenuation. Previously, phase grating moiré interferometers (PGMI) with two or three phase gratings have been developed. These phase-grating systems use the moiré far-field technique to avoid the need for high-aspect absorption gratings used in Talbot-Lau interferometers (TLI) that reduce the neutron flux reaching the detector. We first demonstrate, through theory and simulations, a novel phase grating interferometer system for cold neutrons that requires a single modulated phase grating (MPG) for phase-contrast imaging, as opposed to the two or three phase gratings in previously employed PGMI systems. The …

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Amino Acid Derivatives Of Chlorin-E6—A Review, Maria Da Graça H. Vicente, Kevin M. Smith Apr 2023

Amino Acid Derivatives Of Chlorin-E6—A Review, Maria Da Graça H. Vicente, Kevin M. Smith

Faculty Publications

Details of the structural elucidation of the clinically useful photodynamic therapy sensitizer NPe6 (15) are presented. NPe6, also designated as Laserphyrin, Talaporfin, and LS-11, is a second-generation photosensitizer derived from chlorophyll-a, currently used in Japan for the treatment of human lung, esophageal, and brain cancers. After the initial misidentification of the structure of this chlorin-e6 aspartic acid conjugate as (13), NMR and other synthetic procedures described herein arrived at the correct structure (15), confirmed using single crystal X-ray crystallography. Interesting new features of chlorin-e6 chemistry (including the intramolecular formation of an anhydride (24)) are reported, allowing chemists to regioselectively conjugate …

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New Boron Delivery Agents, Annette G. Beck-Sickinger, Daniel P. Becker, Oksana Chepurna, Bhaskar Das, Sebastian Flieger, Evamarie Hey-Hawkins, Narayan Hosmane, Satish S. Jalisatgi, Hiroyuki Nakamura, Rameshwar Patil, Maria Da Graça H. Vicente, Clara Viñas Apr 2023

New Boron Delivery Agents, Annette G. Beck-Sickinger, Daniel P. Becker, Oksana Chepurna, Bhaskar Das, Sebastian Flieger, Evamarie Hey-Hawkins, Narayan Hosmane, Satish S. Jalisatgi, Hiroyuki Nakamura, Rameshwar Patil, Maria Da Graça H. Vicente, Clara Viñas

Faculty Publications

This proceeding article compiles current research on the development of boron delivery drugs for boron neutron capture therapy that was presented and discussed at the National Cancer Institute (NCI) Workshop on Neutron Capture Therapy that took place on April 20-22, 2022. The most used boron sources are icosahedral boron clusters attached to peptides, proteins (such as albumin), porphyrin derivatives, dendrimers, polymers, and nanoparticles, or encapsulated into liposomes. These boron clusters and/or carriers can be labeled with contrast agents allowing for the use of imaging techniques, such as PET, SPECT, and fluorescence, that enable quantification of tumor-localized boron and their use …

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A Process For Converting An In-Person Training To Increase Church Capacity To Implement Physical Activity And Healthy Eating Practices And Policies To An Online Format, Sara Wilcox Phd, Ruth P. Saunders Ph.D., Jessica Stucker, Andrew T. Kaczynski Ph.D., Kelsey R. Day, Deborah Kinnard, Lindsay Decker, John A. Bernhart Ph.D., Mph, Ches Apr 2023

A Process For Converting An In-Person Training To Increase Church Capacity To Implement Physical Activity And Healthy Eating Practices And Policies To An Online Format, Sara Wilcox Phd, Ruth P. Saunders Ph.D., Jessica Stucker, Andrew T. Kaczynski Ph.D., Kelsey R. Day, Deborah Kinnard, Lindsay Decker, John A. Bernhart Ph.D., Mph, Ches

Faculty Publications

The implementation of evidence-based public health programs into practice is critical for improving health, but trainings for organizational change agents are often not scalable. To describe the process of converting a training that targets faith-based organizational capacity development from an in-person to an online format. We engaged in an iterative process to convert the training delivery mode from in-person to online that included assessing stakeholder support, consulting the literature on best practices, seeking a design team, consolidating content, designing engaging lessons, and building an online site. Feedback from end-users and other audiences was incorporated throughout. Pilot participants with characteristics like …

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A Survey Of South Carolina Pharmacists' Readiness To Prescribe Human Immunodeficiency Virus Pre-Exposure Prophylaxis, Charles M. Burns, Kyle Endres, Caroline Derrick, Alexandra Cooper, Patricia Fabel, Nwora Lance Okeke, Divya Ahuja, Amy Corneli, Mehri S. Mckellar Apr 2023

A Survey Of South Carolina Pharmacists' Readiness To Prescribe Human Immunodeficiency Virus Pre-Exposure Prophylaxis, Charles M. Burns, Kyle Endres, Caroline Derrick, Alexandra Cooper, Patricia Fabel, Nwora Lance Okeke, Divya Ahuja, Amy Corneli, Mehri S. Mckellar

Faculty Publications

Introduction: Human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP) is largely underutilized in the Southern United States. Given their community presence, pharmacists are well positioned to provide PrEP within rural, Southern regions. However, pharmacists' readiness to prescribe PrEP in these communities remains unknown. Objective: To determine the perceived feasibility and acceptability of prescribing PrEP by pharmacists in South Carolina (SC). Methods: We distributed a 43-question online descriptive survey through the University of South Carolina Kennedy Pharmacy Innovation Center's listserv of licensed SC pharmacists. We assessed pharmacists' comfort, knowledge, and readiness to provide PrEP. Results: A total of 150 pharmacists responded to …

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Electric Vehicle Subsidies: Time To Accelerate Or Pump The Brakes?, Tamara L. Sheldon, Rubal Dua, Omar Abdullah Alharbi Apr 2023

Electric Vehicle Subsidies: Time To Accelerate Or Pump The Brakes?, Tamara L. Sheldon, Rubal Dua, Omar Abdullah Alharbi

Faculty Publications

Promoting plug-in electric vehicle (PEV) adoption through subsidies represents a commonly used policy lever for decarbonizing the light-duty vehicle sector. However, it is unclear how the subsidy cost-effectiveness has evolved over time and whether further subsidization is needed to induce adoption beyond wealthy consumers. We explore these questions by assessing the federal PEV subsidy program in the United States. To do so, we extend Sheldon and Dua's (2019a, 2019b) work by using the same approach on large-scale U.S. new vehicle buyer survey data. While results averaged over fuel-types suggest that PEV subsidies are becoming less impactful and costlier over time, …

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Utilizing The System Engineering Trade Study Analysis Method To Analyze Patient Aeromedical Evacuation, Sara Shaghaghi, Jeremy M. Slagley, Michael E. Miller, Gaiven Varshney Apr 2023

Utilizing The System Engineering Trade Study Analysis Method To Analyze Patient Aeromedical Evacuation, Sara Shaghaghi, Jeremy M. Slagley, Michael E. Miller, Gaiven Varshney

Faculty Publications

The US Air Force has gone through many aeromedical patient isolation transport system designs. The first designs were developed in response to the Ebola outbreak in 2014 and, more recently, the COVID-19 pandemic. The trade study analysis part of the system engineering design method was used to analyze the historic and current aeromedical patient contamination control transport systems. A trade study is a process that evaluates alternatives based upon various “-ilities”, such as reconfigurability, flexibility, durability, cost, and more, and performs a systematic analysis to aid designers in producing a ‘good’ design alternative given the large set of possible solutions. …

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Effect Of Stimulator Of Interferon Genes (Sting) Signaling On Radiation-Induced Chemokine Expression In Human Osteosarcoma Cells, Sita S. Withers, Cambri E. Moeller, Cally N. Quick, Chin Chi Liu, Shelby M. Baham, Jayme S. Looper, Ramesh Subramanian, Konstantin G. Kousoulas Apr 2023

Effect Of Stimulator Of Interferon Genes (Sting) Signaling On Radiation-Induced Chemokine Expression In Human Osteosarcoma Cells, Sita S. Withers, Cambri E. Moeller, Cally N. Quick, Chin Chi Liu, Shelby M. Baham, Jayme S. Looper, Ramesh Subramanian, Konstantin G. Kousoulas

Faculty Publications

Cancer cell-intrinsic mechanisms affecting radiation immunomodulation could be exploited to optimize systemic effects of localized radiation. Radiation-induced DNA damage is sensed by cyclic GMP-AMP synthase (cGAS), which ultimately activates stimulator of interferon (IFN) genes (STING). Resultant expression of soluble mediators such as CCL5 and CXCL10 can facilitate recruitment of dendritic cells and immune effector cells into the tumor. The primary objectives of this study were to determine the baseline expression levels of cGAS and STING in OSA cells and evaluate the dependence of OSA cells on STING signaling for eliciting radiation-induced expression of CCL5 and CXCL10. cGAS and STING expression, …

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High-Protein Rice Flour In The Development Of Gluten-Free Pasta, Ana I.Serrano Marana, Anita Morris, Witoon Prinyawiwatkul, Zhimin Xu, Joan M. King Apr 2023

High-Protein Rice Flour In The Development Of Gluten-Free Pasta, Ana I.Serrano Marana, Anita Morris, Witoon Prinyawiwatkul, Zhimin Xu, Joan M. King

Faculty Publications

Abstract: Cahokia Rice, a new biofortified high-protein (10%–12%) variety of rice, was used to develop and analyze a gluten-free pasta. Different pastas were made with high-protein white rice flour (HPWRP), high-protein brown rice flour (HPBRP), commercial white rice flour (CWRP), commercial brown rice flour (CBRP), and wheat flour (WP). Cooking quality of the pasta was evaluated by measuring pasting properties, cooking time, water absorption capacity, and cooking loss. Proximate analysis, color, and texture were done on dry and cooked pasta. Sensory testing was done to determine consumer acceptability and purchase intent of HPWRP and HPBRP in comparison to WP. HPWRP …

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The Flower Garden Banks Siderastrea Siderea Coral As A Candidate Global Boundary Stratotype Section And Point For The Anthropocene Series, Kristine L. Delong, Kylie Palmer, Amy J. Wagner, Mudith M. Weerabaddana, Niall Slowey, Achim D. Herrmann, Nicolas Duprey, Alfredo Martínez-García, Jonathan Jung, Irka Hajdas, Neil L. Rose, Sarah L. Roberts, Lucy R. Roberts, Andrew B. Cundy, Pawel Gaca, J. Andrew Milton, Handong Yang, Simon D. Turner, Chun Yuan Huang, Chuan Chou Shen, Jens Zinke Apr 2023

The Flower Garden Banks Siderastrea Siderea Coral As A Candidate Global Boundary Stratotype Section And Point For The Anthropocene Series, Kristine L. Delong, Kylie Palmer, Amy J. Wagner, Mudith M. Weerabaddana, Niall Slowey, Achim D. Herrmann, Nicolas Duprey, Alfredo Martínez-García, Jonathan Jung, Irka Hajdas, Neil L. Rose, Sarah L. Roberts, Lucy R. Roberts, Andrew B. Cundy, Pawel Gaca, J. Andrew Milton, Handong Yang, Simon D. Turner, Chun Yuan Huang, Chuan Chou Shen, Jens Zinke

Faculty Publications

The proposed Anthropocene Global Boundary Stratotype Section and Point (GSSP) candidate site of West Flower Garden Bank (27.8762°N, 93.8147°W) is an open ocean location in the Gulf of Mexico with a submerged coral reef and few direct human impacts. Corals contain highly accurate and precise (<±1 year) internal chronologies, similar to tree rings, and their exoskeletons are formed of aragonite and can be preserved in the rock record. Here we present results from a large Siderastrea siderea coral (core 05WFGB3; 1755–2005 CE) sampled with annual and monthly resolutions that show clear markers of global and regional human impacts. Atmospheric nuclear bomb testing by-products (14C, 239+240Pu) have clear increases in this coral starting in 1957 for 14C and the first increase in 1956 for 239+240Pu (potential bases for the Anthropocene GSSP). Coral δ13C declined especially after 1956 consistent with the Suess effect resulting from the burning of fossil fuels. Coral skeletal δ15N starts to increase in 1963 corresponding with the increase in agricultural fertilizers. Coral Hg concentrations (1933–1980) loosely track fluctuations in industrial pollution and coral Ba/Ca increases from 1965–1983 when offshore oil operations expand after 1947. Coral temperature proxies contain the 20th-century global warming trend whereas coral growth declines during this interval.

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North Flinders Reef (Coral Sea, Australia) Porites Sp. Corals As A Candidate Global Boundary Stratotype Section And Point For The Anthropocene Series, Jens Zinke, Neal E. Cantin, Kristine L. Delong, Kylie Palmer, Arnoud Boom, Irka Hajdas, Nicolas Duprey, Alfredo Martínez-García, Neil L. Rose, Sarah L. Roberts, Handong Yang, Lucy R. Roberts, Andrew B. Cundy, Pawel Gaca, James Andy Milton, Grace Frank, Adam Cox, Sue Sampson, Genevieve Tyrrell, Molly Agg, Simon D. Turner Apr 2023

North Flinders Reef (Coral Sea, Australia) Porites Sp. Corals As A Candidate Global Boundary Stratotype Section And Point For The Anthropocene Series, Jens Zinke, Neal E. Cantin, Kristine L. Delong, Kylie Palmer, Arnoud Boom, Irka Hajdas, Nicolas Duprey, Alfredo Martínez-García, Neil L. Rose, Sarah L. Roberts, Handong Yang, Lucy R. Roberts, Andrew B. Cundy, Pawel Gaca, James Andy Milton, Grace Frank, Adam Cox, Sue Sampson, Genevieve Tyrrell, Molly Agg, Simon D. Turner

Faculty Publications

Corals are unique in the suite of proposed Anthropocene Global Boundary Stratotype Section and Point (GSSP) archives, as living organisms that produce aragonite exoskeletons preserved in the geological record that contain highly accurate and precise (<±1 year) internal chronologies. The GSSP candidate site North Flinders Reef in the Coral Sea (Australia) is an offshore oceanic reef, and therefore less vulnerable to local human influences than those closer to the coast. Here, we present geochemical records from two Porites sp. corals sampled at an annual to pluri-annual (i.e. 3–5 years) resolution that shows clear global and regional human impacts. Atmospheric nuclear bomb testing by-products (14C,239+240Pu) show a clear increase in the Flinders Reef corals coincident with well-dated nuclear testing operations. By contrast, the radionuclides 241Am and 137Cs are present at low or undetectable levels, as are spheroidal carbonaceous fly-ash particles. Coral δ13C shows centennial variability likely influenced by growth effects in the 18th century and with a progression to lower values starting in 1880 CE and accelerating post-1970 CE. The latter may be related to the Suess effect resulting from 13C-depleted fossil fuel burning. Coral δ15N decreased between 1710 and 1954 CE with a reversal post-1954 CE. Coral temperature proxies indicate prominent centennial variability with equally warm conditions in the 18th and end of 20th century. However, the exact mechanisms responsible for the mid-20th century changes in these parameters need to be scrutinised in further detail. Plain Language summary: This work proposes a candidate natural archive for the official marker of the Anthropocene that geologists will use to mark this important interval in time. Our candidate is a live coral from North Flinders Reef in the Coral Sea (Australia), located 150 km east of the Great Barrier Reef, a location that is remote from direct local human influences. Corals are a unique archive of tropical ocean change because they incorporate the geochemical signature from seawater into their limestone skeleton during their long life-spans. Here we investigated a number of geochemical markers in yearly growth layers of the corals to define several markers for the Anthropocene based on changes in temperature, water chemistry, chemicals from pollution and fertilisers, radioactive products from nuclear bomb testing, and by-products from burning fossil fuels. We have detected clear human influences in several of these markers.

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Not Just Income: The Enabling Role Of Institutional Confidence And Social Capital In Household Energy Transitions In India, Anmol Soni, Anomitro Chatterjee Apr 2023

Not Just Income: The Enabling Role Of Institutional Confidence And Social Capital In Household Energy Transitions In India, Anmol Soni, Anomitro Chatterjee

Faculty Publications

Transitioning to cleaner forms of cooking energy is a key facet of sustainable development. Despite numerous programs, the transition in developing countries remains slow and sometimes non-existent. Even when cleaner sources of cooking energy are adopted, their use is often temporary, with households continuing to use traditional energy sources. While literature identifies the importance of affordability and access, factors such as trust in local institutions and social capital remain under-explored. We aim to fill this gap by using household-level panel data to estimate drivers of clean cooking technology adoption and sustained fuel use in India. We add to the current …

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