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A Critical Systematic Literature Review Of Global Inclusive Education Using An Affective, Intersectional, Discursive, Emotive And Material Lens, David Isaac Hernández-Saca, Catherine Kramarczuk Voulgarides, Susan Larson Etscheidt Dec 2023

A Critical Systematic Literature Review Of Global Inclusive Education Using An Affective, Intersectional, Discursive, Emotive And Material Lens, David Isaac Hernández-Saca, Catherine Kramarczuk Voulgarides, Susan Larson Etscheidt

Faculty Publications

We conducted a critical systematic literature review on global inclusive education and law. The critical review questions were: (1) how have scholars theorized, conceptualized, and studied global inclusive education? (2) How do scholars define global inclusive education? (3) And what do scholars cite as prominent international inclusive education law? We ask such questions given the ongoing global crises that situate historically marginalized groups in even more precarious positions—including students with dis/Abilities. Given this framing, we employed a critical systematic literature review that is cognizant of our positionalities, writing from the Global North, so that we can identify lines of inquiry …

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Uncovering The Environmental Conditions Required For Phyllachora Maydis Infection And Tar Spot Development On Corn In The United States For Use As Predictive Models For Future Epidemics, Richard W. Webster, Camila Nicolli, Tom W. Allen, Mandy D. Bish, Kaitlyn Bissonnette, Jill C. Check, Martin I. Chilvers, Maíra R. Duffeck, Nathan Kleczewski, Jane Marian Luis, Brian D. Mueller, Pierce A. Paul, Paul P. Price, Alison E. Robertson, Tiffanna J. Ross, Clarice Schmidt, Roger Schmidt, Teryl Schmidt, Sujoung Shim, Darcy E.P. Telenko, Kiersten Wise, Damon L. Smith Dec 2023

Uncovering The Environmental Conditions Required For Phyllachora Maydis Infection And Tar Spot Development On Corn In The United States For Use As Predictive Models For Future Epidemics, Richard W. Webster, Camila Nicolli, Tom W. Allen, Mandy D. Bish, Kaitlyn Bissonnette, Jill C. Check, Martin I. Chilvers, Maíra R. Duffeck, Nathan Kleczewski, Jane Marian Luis, Brian D. Mueller, Pierce A. Paul, Paul P. Price, Alison E. Robertson, Tiffanna J. Ross, Clarice Schmidt, Roger Schmidt, Teryl Schmidt, Sujoung Shim, Darcy E.P. Telenko, Kiersten Wise, Damon L. Smith

Faculty Publications

Phyllachora maydis is a fungal pathogen causing tar spot of corn (Zea mays L.), a new and emerging, yield-limiting disease in the United States. Since being first reported in Illinois and Indiana in 2015, P. maydis can now be found across much of the corn growing regions of the United States. Knowledge of the epidemiology of P. maydis is limited but could be useful in developing tar spot prediction tools. The research presented here aims to elucidate the environmental conditions necessary for the development of tar spot in the field and the creation of predictive models to anticipate future tar …

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The Influence Of Salinity And Vegetation Texture On The Ecological Roles Of Insects In Tidal Marshes In Louisiana, Benjamin G. Aker, Claudia Husseneder, Lane D. Foil Dec 2023

The Influence Of Salinity And Vegetation Texture On The Ecological Roles Of Insects In Tidal Marshes In Louisiana, Benjamin G. Aker, Claudia Husseneder, Lane D. Foil

Faculty Publications

Tidal marsh insect communities are influenced by both salinity and aspects of vegetation texture (vegetation diversity, plant density, and architectural structure). These factors affect the abundances and intra- and interguild interactions of these insects and should result in broad-scale variation in the distribution and ecological functioning of tidal marsh insect communities along these gradients. However, this assumption has not been tested within Gulf Coast marshes, and the insect communities and their ecological roles are not well known. This study identifies how family-level insect biodiversity varies by salinity and which factors are most important in affecting the distribution of insect functional …

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A Survey On Mosquito Control Knowledge And Insecticide Use In New Orleans, La, 2020–2021, Erin R. Cloherty, Janet C. Mcallister, James A. Ottea, Kristen Healy, Claudia Riegel Dec 2023

A Survey On Mosquito Control Knowledge And Insecticide Use In New Orleans, La, 2020–2021, Erin R. Cloherty, Janet C. Mcallister, James A. Ottea, Kristen Healy, Claudia Riegel

Faculty Publications

Mosquitoes are a known public nuisance and can vector various diseases. Historically, New Orleans, LA, has long been acquainted with the burden of mosquito-borne diseases, such as malaria and yellow fever in the 20th century and West Nile virus in the 21st century. Government mosquito control awareness campaigns have been around for decades as has the use of organophosphate and pyrethroid insecticides by mosquito abatement districts. However, few data are available on public perception of mosquito control and public usage of insecticides to kill mosquitoes in New Orleans. We conducted a survey from August 2020 to July 2021 to evaluate …

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Droid: Dose-Ranging Approach To Optimizing Dose In Oncology Drug Development, Beibei Guo, Ying Yuan Dec 2023

Droid: Dose-Ranging Approach To Optimizing Dose In Oncology Drug Development, Beibei Guo, Ying Yuan

Faculty Publications

In the era of targeted therapy, there has been increasing concern about the development of oncology drugs based on the “more is better” paradigm, developed decades ago for chemotherapy. Recently, the US Food and Drug Administration (FDA) initiated Project Optimus to reform the dose optimization and dose selection paradigm in oncology drug development. To accommodate this paradigm shifting, we propose a dose-ranging approach to optimizing dose (DROID) for oncology trials with targeted drugs. DROID leverages the well-established dose-ranging study framework, which has been routinely used to develop non-oncology drugs for decades, and bridges it with established oncology dose-finding designs to …

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Discovery Of A New Highly Pathogenic Toxin Involved In Insect Sepsis, Yuan Zhang, Hao Li, Fang Wang, Chang Liu, Gadi V.P. Reddy, Hu Li, Zhihong Li, Yucheng Sun, Zihua Zhao Dec 2023

Discovery Of A New Highly Pathogenic Toxin Involved In Insect Sepsis, Yuan Zhang, Hao Li, Fang Wang, Chang Liu, Gadi V.P. Reddy, Hu Li, Zhihong Li, Yucheng Sun, Zihua Zhao

Faculty Publications

Insect sepsis is a severe consequence that arises from the invasion of the hemocoel by symbionts of entomopathogenic nematodes and bacteria. In the present study, we unveiled the heightened virulence of the entomopathogenic nematode Steinernema feltiae and the entomopathogenic bacteria Xenorhabdus bovienii, which operate symbiotically, against the wax moth Galleria mellonella. Maximum mortality was observed at 25°C while the optimal infestation efficiency was 20 nematodes per host. After infestation, G. mellonella displayed rapid darkening and softening, accompanied by an escalated esterase activity at 9 h. The X. bovienii, released by S. feltiae, underwent substantial proliferation and discharged toxins that attacked …

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A Chromosome Scale Assembly Of The Tarnished Plant Bug, Lygus Lineolaris (Palisot De Beauvois), Genome, O. P. Perera, Surya Saha, James Glover, Katherine A. Parys, K. Clint Allen, Snejana Grozeva, Ryan Kurtz, Gadi V.P. Reddy, J. Spencer Johnston, Mark Daly, Thomas Swale Dec 2023

A Chromosome Scale Assembly Of The Tarnished Plant Bug, Lygus Lineolaris (Palisot De Beauvois), Genome, O. P. Perera, Surya Saha, James Glover, Katherine A. Parys, K. Clint Allen, Snejana Grozeva, Ryan Kurtz, Gadi V.P. Reddy, J. Spencer Johnston, Mark Daly, Thomas Swale

Faculty Publications

Objective: The tarnished plant bug (TPB), Lygus lineolaris (Palisot de Beauvois) (Hemiptera: Miridae), is a pest damaging many cultivated crops in North America. Although partial transcriptome data are available for this pest, a genome assembly was not available for this species. This assembly of a high-quality chromosome-length genome of TPB is aimed to develop the genetic resources that can provide the foundation required for advancing research on this species. Results: The initial genome of TPB assembled with paired-end nucleotide sequences generated with Illumina technology was scaffolded with Illumina HiseqX reads generated from a proximity ligated (HiC) library to obtain a …

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Taxonomic Profiling Of Nasutitermes Takasagoensis Microbiota To Investigate The Role Of Termites As Vectors Of Bacteria Linked To Ironwood Tree Decline In Guam, Garima Setia, Junyan Chen, Robert Schlub, Claudia Husseneder Dec 2023

Taxonomic Profiling Of Nasutitermes Takasagoensis Microbiota To Investigate The Role Of Termites As Vectors Of Bacteria Linked To Ironwood Tree Decline In Guam, Garima Setia, Junyan Chen, Robert Schlub, Claudia Husseneder

Faculty Publications

The ironwood tree (Casuarina equisetifolia, family Casuarinaceae), an indigenous agroforestry species in Guam, has been threatened by ironwood tree decline (IWTD) since 2002. Formation of bacterial ooze by the wilt pathogen from the Ralstonia solanacearum species complex and wetwood bacteria (primarily Klebsiella species) has been linked to IWTD. In addition, termite infestation of trees was statistically associated with IWTD. Termites are known carriers of a diverse microbiome. Therefore, we hypothesized that termites could be vectors of bacteria linked to IWTD. To investigate the potential role of termites as pathogen vectors, we employed next-generation 16S rRNA gene sequencing to describe the …

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Right Frontal Hd-Tdcs Reveals Causal Involvement Of Time Perception Networks In Temporal Processing Of Concepts, Karim Johari, Fatemeh Tabari, Rutvik H. Desai Dec 2023

Right Frontal Hd-Tdcs Reveals Causal Involvement Of Time Perception Networks In Temporal Processing Of Concepts, Karim Johari, Fatemeh Tabari, Rutvik H. Desai

Faculty Publications

Evidence suggests that perceptual and action related features of concepts are grounded in the corresponding sensory-motor networks in the human brain. However, less is known about temporal features of event concepts (e.g., a lecture) and whether they are grounded in time perception networks. We examined this question by stimulating the right dorsolateral prefrontal cortex (rDLPFC)—a part of time perception network—using HD-tDCS and subsequently recording EEG while participants performed semantic and time perception tasks. Semantic tasks were composed of event noun duration judgment (EDur), object noun size judgement (OSize), event (EVal) and object noun valence judgement. In the time perception task, …

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A Repeated-Measures Study Of Relational Turbulence And Transition Processing Communication During The Summer Of Covid-19 (Summer 2020), Kellie St Cyr Brisini, Denise Haunani Solomon Dec 2023

A Repeated-Measures Study Of Relational Turbulence And Transition Processing Communication During The Summer Of Covid-19 (Summer 2020), Kellie St Cyr Brisini, Denise Haunani Solomon

Faculty Publications

Drawing upon relational turbulence theory and the experiencing life transitions model, this study examined communication and relationship qualities as married couples experienced work-family changes during the COVID-19 pandemic. Sixty-four American married, different-sex partners affected by job-related changes due to COVID-19 reported their relationship qualities and their own and their spouse’s engagement in transition processing communication weekly for 10 weeks. Hypotheses addressed associations between relationship qualities and communication experiences both averaged across the 10 weeks and indexed by within-week deviations from those averages, controlling for the previous week’s reports. Husbands’ and wives’ own attempts—and also their perceptions of their spouse’s attempts—to …

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Linking Stress To The Emergence Of Relational Turbulence In Marriage, Kellie St Cyr Brisini, Denise Haunani Solomon, Miriam Brinberg Dec 2023

Linking Stress To The Emergence Of Relational Turbulence In Marriage, Kellie St Cyr Brisini, Denise Haunani Solomon, Miriam Brinberg

Faculty Publications

The assumption that stress negatively impacts marital relationships is widely accepted; however, the majority of research has focused on marital satisfaction as the outcome of interest. Relational turbulence is a quality of romantic associations on par with—but distinct from—satisfaction, in which partners conceptualize their relationship as chaotic or tumultuous. This paper draws on relational turbulence theory (RTT) and stress spillover research to propose that day-to-day stress corresponds with perceptions of relational uncertainty and interdependence, which contributes to increases in relational turbulence. We evaluated these assumptions using data from 64 heterosexual married partners who experienced work-related disruptions due to the COVID-19 …

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Building Resilience To Extreme Weather And Climate Events In The Rural Water And Wastewater Sectors, Nathan P. Kettle, Sarah F. Trainor, Renee Edwards, Donald Antrobus, Curt Baranowski, Tina Buxbaum, Kevin Berry, Michael Brubaker, Kristine L. De Long, Steve Fries, Davin Holen, Barry Keim, Danielle Meeker, Harry Penn, Cheryl Rosa, Rick Thoman, John Walsh, Jian Zhang Dec 2023

Building Resilience To Extreme Weather And Climate Events In The Rural Water And Wastewater Sectors, Nathan P. Kettle, Sarah F. Trainor, Renee Edwards, Donald Antrobus, Curt Baranowski, Tina Buxbaum, Kevin Berry, Michael Brubaker, Kristine L. De Long, Steve Fries, Davin Holen, Barry Keim, Danielle Meeker, Harry Penn, Cheryl Rosa, Rick Thoman, John Walsh, Jian Zhang

Faculty Publications

Extreme weather and climate events pose significant risks to rural water and wastewater systems. We examine the vulnerability of the water sector to weather and climate extremes in rural, predominantly Indigenous and underserved coastal areas and analyze how networks support resilience. Drawing on the analysis of 39 web-based questionnaire responses and 19 interviews with rural water and wastewater managers and service providers in southern Louisiana and western Alaska, this article reports a range of interrelated historical, environmental, and social factors that influence vulnerability to extreme weather events. Formal and informal social networks serve multiple roles in building resilience. These roles …

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Mechanical And Thermal Properties Of Mud Dauber Nests Under Atmospheric Drying, Joon S. Park, Hai Lin, Hussein Alqrinawi Dec 2023

Mechanical And Thermal Properties Of Mud Dauber Nests Under Atmospheric Drying, Joon S. Park, Hai Lin, Hussein Alqrinawi

Faculty Publications

Mud dauber wasps construct soil nests to protect their offspring from predators, extreme temperatures, and rainwater. The mechanical and thermal properties of these nests are important for the reproductive success of mud daubers. The previous study showed that the high densities and strengths of mud dauber nests were due to the repetitive tapping and atmospheric drying used by mud daubers during nest construction. This study investigated the effect of atmospheric drying on the mechanical and thermal properties of mud dauber nests. The soil shrinkage curve, elastic modulus, suction stress characteristic curve, soil water retention curve, shear strength, and thermal conductivity …

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Science Foundations And The Bulletin, Bret Collier, Anna Knipps, Jeff Levengood, Ashley Tunstall Dec 2023

Science Foundations And The Bulletin, Bret Collier, Anna Knipps, Jeff Levengood, Ashley Tunstall

Faculty Publications

No abstract provided.

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Habitat Selection Of Gould’S Wild Turkeys In Southeastern Arizona, Erin E. Ulrey, Patrick H. Wightman, Nicholas W. Bakner, Byron R. Buckley, Nathan Fyffe, Brittany Oleson, Alex Smallwood, James R. Heffelfinger, Michael J. Chamberlain, Bret A. Collier Dec 2023

Habitat Selection Of Gould’S Wild Turkeys In Southeastern Arizona, Erin E. Ulrey, Patrick H. Wightman, Nicholas W. Bakner, Byron R. Buckley, Nathan Fyffe, Brittany Oleson, Alex Smallwood, James R. Heffelfinger, Michael J. Chamberlain, Bret A. Collier

Faculty Publications

In semi-arid environments, resources necessary for survival may be unevenly distributed across the landscape. Gould’s wild turkeys (Meleagris gallopavo mexicana) are spatially restricted to mountainous semi-arid areas of southwestern United States and Mexico, and information on their distribution and habitat use is limited. We described how landcover type and topographical features influenced space use and habitat selection by Gould’s wild turkeys in southeastern Arizona. We used GPS data from 51 Gould’s wild turkeys to describe resource selection during 2016–2017 in southeastern Arizona, USA. We estimated home ranges and calculated resource selection functions using distance from landcover types, slope, aspect, and …

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Behavioral-Dependent Recursive Movements And Implications For Resource Selection, Nicholas W. Bakner, Bret A. Collier, Michael J. Chamberlain Dec 2023

Behavioral-Dependent Recursive Movements And Implications For Resource Selection, Nicholas W. Bakner, Bret A. Collier, Michael J. Chamberlain

Faculty Publications

Within home ranges, animals repeatedly visit certain areas. Recursive movement patterns are widespread throughout the animal kingdom, but are rarely considered when developing resource selection models. We examined how behavioral state-dependent recursive movements influenced reource selection of eastern wild turkey (Meleagris gallopavo silvestris) broods as they aged from day 1 to 28. Because broods become more plastic in behaviors once they begin roosting off the ground, we separated data into broods that were ground roosting (1–13 days) and tree roosting (14–28 days). We used Hidden Markov Models to identify 2 behavioral states (restricted and mobile). We extracted state-specific recursive movements …

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A Trait Dataset For Freshwater Mussels Of The United States Of America, Garrett W. Hopper, Jamie R. Bucholz, Traci P. Dubose, Kaelyn J. Fogelman, Sean M. Keogh, Megan E. Kubala, Matthew B. Lodato, David H. Nichols, Irene Sánchez González, John M. Pfeiffer, James A. Stoeckel, Jeffrey D. Lozier, Carla L. Atkinson Dec 2023

A Trait Dataset For Freshwater Mussels Of The United States Of America, Garrett W. Hopper, Jamie R. Bucholz, Traci P. Dubose, Kaelyn J. Fogelman, Sean M. Keogh, Megan E. Kubala, Matthew B. Lodato, David H. Nichols, Irene Sánchez González, John M. Pfeiffer, James A. Stoeckel, Jeffrey D. Lozier, Carla L. Atkinson

Faculty Publications

The United States of America has a diverse collection of freshwater mussels comprising 301 species distributed among 59 genera and two families (Margaritiferidae and Unionidae), each having a unique suite of traits. Mussels are among the most imperilled animals and are critical components of their ecosystems, and successful management, conservation and research requires a cohesive and widely accessible data source. Although trait-based analysis for mussels has increased, only a small proportion of traits reflecting mussel diversity in this region has been collated. Decentralized and non-standardized trait information impedes large-scale analysis. Assembling trait data in a synthetic dataset enables comparison across …

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Personalized Feedback Intervention For Individuals With Low Distress Tolerance Who Smoke Cigarettes: A Randomized Controlled Trial Of A Digital Intervention, Brooke Y. Redmond, Aniqua Salwa, Jonathan B. Bricker, Julia D. Buckner, Lorra Garey, Michael J. Zvolensky Dec 2023

Personalized Feedback Intervention For Individuals With Low Distress Tolerance Who Smoke Cigarettes: A Randomized Controlled Trial Of A Digital Intervention, Brooke Y. Redmond, Aniqua Salwa, Jonathan B. Bricker, Julia D. Buckner, Lorra Garey, Michael J. Zvolensky

Faculty Publications

Introduction: Cigarette smoking remains the leading preventable cause of death and disability in the United States and frequently co-occurs with anxiety and depressive symptoms. A novel and integrative, theory-driven approach to address the heterogeneity of mood-related symptoms associated with cigarette use is to focus on transdiagnostic processes, such as distress tolerance, that underpin both mood-related symptoms and smoking behavior. The current study sought to develop and examine the feasibility, acceptability, and initial efficacy of a digitally delivered integrated personalized feedback intervention (PFI) that addresses smoking-distress tolerance relations. Methods: Participants included 121 adults (71.1 % male; Mage = 29.33 years, SD …

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Attentional Biases In Facial Emotion Processing In Individuals At Clinical High Risk For Psychosis, Trevor F. Williams, Alex S. Cohen, Alvaro Sanchez-Lopez, Jutta Joormann, Vijay A. Mittal Dec 2023

Attentional Biases In Facial Emotion Processing In Individuals At Clinical High Risk For Psychosis, Trevor F. Williams, Alex S. Cohen, Alvaro Sanchez-Lopez, Jutta Joormann, Vijay A. Mittal

Faculty Publications

Individuals at clinical high risk (CHR) for psychosis exhibit altered facial emotion processing (FEP) and poor social functioning. It is unclear whether FEP deficits result from attentional biases, and further, how these abnormalities are linked to symptomatology (e.g., negative symptoms) and highly comorbid disorders that are also tied to abnormal FEP (e.g., depression). In the present study, we employed an eye-tracking paradigm to assess attentional biases and clinical interviews to examine differences between CHR (N = 34) individuals and healthy controls (HC; N = 46), as well as how such biases relate to symptoms and functioning in CHR individuals. Although …

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The Brief Adolescent Depression Screen: A Brief Screening Tool For Depression And Suicidal Behavior In Inpatient Adolescents, Erin P. Vaughan, Emily C. Kemp, Emily L. Robertson, Toni M. Walker, Paige Picou, Paul J. Frick, John De Back Dec 2023

The Brief Adolescent Depression Screen: A Brief Screening Tool For Depression And Suicidal Behavior In Inpatient Adolescents, Erin P. Vaughan, Emily C. Kemp, Emily L. Robertson, Toni M. Walker, Paige Picou, Paul J. Frick, John De Back

Faculty Publications

Background: In clinical settings, there is significant need for brief, easily-administered assessment tools for adolescent depression that can be used by mental health clinicians from a variety of training backgrounds. Existing depression screening tools do not assess for duration and consistency of symptoms, two key indicators of pathological depression. Objective: The Brief Adolescent Depression Screen (BADS) was developed to screen for major and persistent depressive disorders in adolescents in order to meet the assessment needs in an inpatient setting, and the validity of this tool was tested. Method: The current study used a sample of 396 inpatient adolescents to assess …

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How Important Is Developmental Maturity In Assessing Whether Adolescents Will Share True Or False Accounts Of A First Offense In Legal Interactions?, Jennifer Lavoie, Adam D. Fine, April G. Thomas, Paul J. Frick, Laurence Steinberg, Elizabeth Cauffman Dec 2023

How Important Is Developmental Maturity In Assessing Whether Adolescents Will Share True Or False Accounts Of A First Offense In Legal Interactions?, Jennifer Lavoie, Adam D. Fine, April G. Thomas, Paul J. Frick, Laurence Steinberg, Elizabeth Cauffman

Faculty Publications

We examined the developmental and situation-specific differences between four groupings of adolescents charged with a first offense: those who committed the crime and told the authorities they committed the crime (true confessors; 71%), those who committed the crime but told the authorities they did not commit the crime (false deniers; 8%), those who did not commit the crime but told the authorities they did commit the crime (false confessors; 12%) and those who did not commit the crime and told the authorities they did not commit the crime (true deniers; 10%). Findings indicate a developmental profile for each respondent grouping, …

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Amazonian Mixed-Species Flocks Demonstrate Flexible Preferences For Vertical Forest Structure, Charles P.J. Coddington, W. Justin Cooper, Cameron L. Rutt, Karl Mokross, Bruna R. Amaral, Philip C. Stouffer, David A. Luther Dec 2023

Amazonian Mixed-Species Flocks Demonstrate Flexible Preferences For Vertical Forest Structure, Charles P.J. Coddington, W. Justin Cooper, Cameron L. Rutt, Karl Mokross, Bruna R. Amaral, Philip C. Stouffer, David A. Luther

Faculty Publications

How species interact with human-disturbed environments is a central focus of conservation biology. Within disturbed landscapes, regenerating forests have potential to provide habitat for forest species, especially as increasing amounts of primary forest are lost. As secondary forest regenerates beside primary forest, it increases habitat heterogeneity. However, relatively little is known about the influence of habitat heterogeneity on space use. In this study, we analyzed the topography and vertical vegetation structure of regenerating forest, small forest fragments, and undisturbed rainforest in the central Amazon to determine (1) how these structural characteristics influence understory mixed-species flock space use and (2) how …

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Genetic Variants Associated With Hantavirus Infection In A Reservoir Host Are Related To Regulation Of Inflammation And Immune Surveillance, Anna A. Pérez-Umphrey, Amie E. Settlecowski, Jean P. Elbers, S. Tyler Williams, Colleen B. Jonsson, Andrea Bonisoli-Alquati, Allison M. Snider, Sabrina S. Taylor Dec 2023

Genetic Variants Associated With Hantavirus Infection In A Reservoir Host Are Related To Regulation Of Inflammation And Immune Surveillance, Anna A. Pérez-Umphrey, Amie E. Settlecowski, Jean P. Elbers, S. Tyler Williams, Colleen B. Jonsson, Andrea Bonisoli-Alquati, Allison M. Snider, Sabrina S. Taylor

Faculty Publications

The immunogenetics of wildlife populations influence the epidemiology and evolutionary dynamic of the host-pathogen system. Profiling immune gene diversity present in wildlife may be especially important for those species that, while not at risk of disease or extinction themselves, are host to diseases that are a threat to humans, other wildlife, or livestock. Hantaviruses (genus: Orthohantavirus) are globally distributed zoonotic RNA viruses with pathogenic strains carried by a diverse group of rodent hosts. The marsh rice rat (Oryzomys palustris) is the reservoir host of Orthohantavirus bayoui, a hantavirus that causes fatal cases of hantavirus cardiopulmonary syndrome in humans. We performed …

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Modeling Of Cryopreservation Pathway Operation At An Aquatic Biomedical Stock Center For Zebrafish, Sarah Bodenstein, Fidan Abdullayeva, Joy M. Murphy, Zoltan M. Varga, Terrence R. Tiersch Dec 2023

Modeling Of Cryopreservation Pathway Operation At An Aquatic Biomedical Stock Center For Zebrafish, Sarah Bodenstein, Fidan Abdullayeva, Joy M. Murphy, Zoltan M. Varga, Terrence R. Tiersch

Faculty Publications

Aquatic biomedical model organisms play a substantial role in advancing our understanding of human health, however, comparably little work has been directed towards developing dependable, high-throughput storage programs for valuable genetic resources. The Zebrafish International Resource Center (ZIRC) has developed a standardized cryopreservation pathway and stored thousands of genetic lines in their repository for use by the biomedical research community. This has yet to be replicated in other facilities, and an overall repository-level pathway has never been analyzed for aquatic species. To encourage repository development for other biomedical models and to improve the ZIRC storage process and system, this study …

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Simulation Analysis Of High-Throughput Oyster Cryopreservation At Three Scales Of Production, Sarah Bodenstein, Isabelina Nahmens, Brian R. Callam, Terrence R. Tiersch Dec 2023

Simulation Analysis Of High-Throughput Oyster Cryopreservation At Three Scales Of Production, Sarah Bodenstein, Isabelina Nahmens, Brian R. Callam, Terrence R. Tiersch

Faculty Publications

Cryopreservation and germplasm repositories offer a variety of potential benefits to aquaculture industries. Despite this, no comprehensive repository systems exist for any prominent aquaculture species. A species that could greatly benefit from the use of cryopreserved sperm and repository storage is the eastern oyster, Crassostrea virginica. High-throughput cryopreservation protocols already exist for this species, and the easy transport of frozen sperm could facilitate selective breeding programs that address pressing challenges currently faced in the industry, such as mortality due to low-salinity conditions. This study addressed the gap between cryopreservation protocols and repository development in the oyster industry by creating simulation …

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Mutual-Information Based Optimal Experimental Design For Hyperpolarized 13 C-Pyruvate Mri, Prashant K. Jha, Christopher Walker, Drew Mitchell, J. Tinsley Oden, Dawid Schellingerhout, James A. Bankson, David T. Fuentes Dec 2023

Mutual-Information Based Optimal Experimental Design For Hyperpolarized 13 C-Pyruvate Mri, Prashant K. Jha, Christopher Walker, Drew Mitchell, J. Tinsley Oden, Dawid Schellingerhout, James A. Bankson, David T. Fuentes

Faculty Publications

A key parameter of interest recovered from hyperpolarized (HP) MRI measurements is the apparent pyruvate-to-lactate exchange rate, kPL , for measuring tumor metabolism. This manuscript presents an information-theory-based optimal experimental design approach that minimizes the uncertainty in the rate parameter, kPL , recovered from HP-MRI measurements. Mutual information is employed to measure the information content of the HP measurements with respect to the first-order exchange kinetics of the pyruvate conversion to lactate. Flip angles of the pulse sequence acquisition are optimized with respect to the mutual information. A time-varying flip angle scheme leads to a higher parameter optimization that can …

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Preferred Atmospheric Circulations Associated With Favorable Prescribed Burns In The Gulf Of Mexico Coast, Usa, Chelsea S. Kross, Robert V. Rohli, Jena A. Moon, Auriel M.V. Fournier, Mark S. Woodrey, J. Andrew Nyman Dec 2023

Preferred Atmospheric Circulations Associated With Favorable Prescribed Burns In The Gulf Of Mexico Coast, Usa, Chelsea S. Kross, Robert V. Rohli, Jena A. Moon, Auriel M.V. Fournier, Mark S. Woodrey, J. Andrew Nyman

Faculty Publications

Background: Application of prescribed fire in natural plant communities is an important wildlife habitat management tool. Prescribed fire managers have suggested anecdotally that changing weather patterns may be influencing the frequency of days that have optimal conditions to conduct coastal marsh burns along the US Gulf of Mexico coast. Our study objectives were to (1) determine whether the frequency of atmospheric circulation patterns associated with prescribed fire prescriptions has changed from 1979 to 2018 for the Gulf Coast and (2) identify circulation patterns preferred by land managers for implementing prescribed fire. Results: While coastal marsh habitat is threatened by climate …

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Spin-4/Spinster Supports Sperm Activation In C. Elegans Via Sphingosine-1-Phosphate Transport, Yash Flora, K. Adam Bohnert Dec 2023

Spin-4/Spinster Supports Sperm Activation In C. Elegans Via Sphingosine-1-Phosphate Transport, Yash Flora, K. Adam Bohnert

Faculty Publications

Spermiogenesis, a sperm-activation step, is crucial for the transformation of immotile spermatids into motile sperm. Though membrane transport of ions and molecules across the sperm plasma membrane has been implicated in this process, the full repertoire of transporters involved, and their respective substrates, is unclear. Here, we report that the major facilitator superfamily transporter SPIN-4/Spinster governs efficient spermiogenesis and fertility in the hermaphrodite nematode Caenorhabditis elegans. Unlike other C. elegans Spinster paralogs, SPIN-4 is germline-expressed. Moreover, SPIN-4 expression is gamete-specific; it is strongly expressed in developing sperm, where it localizes to the plasma membrane, but it is absent from oocytes. …

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Edwardsiella Ictaluri T3ss Effector Esen Is A Phosphothreonine Lyase That Inactivates Erk1/2, P38, Jnk, And Pdk1 And Modulates Cell Death In Infected Macrophages, Ranjan Koirala, Chanida Fongsaran, Tanisha Poston, Matthew Rogge, Bryan Rogers, Ronald Thune, Lidiya Dubytska Dec 2023

Edwardsiella Ictaluri T3ss Effector Esen Is A Phosphothreonine Lyase That Inactivates Erk1/2, P38, Jnk, And Pdk1 And Modulates Cell Death In Infected Macrophages, Ranjan Koirala, Chanida Fongsaran, Tanisha Poston, Matthew Rogge, Bryan Rogers, Ronald Thune, Lidiya Dubytska

Faculty Publications

EseN is an Edwardsiella ictaluri type III secretion system effector with phosphothreonine lyase activity. In this work, we demonstrate that EseN inactivates p38 and c-Jun-N-terminal kinase (JNK) in infected head-kidney-derived macrophages (HKDMs). We have previously reported inactivation of extracellular-regulated kinase 1/2 (ERK1/2). Also, for the first time, we demonstrated that EseN is involved in the inactivation of 3-phosphoinositide-dependent kinase 1 (PDK1), which has not been previously demonstrated for any of the EseN homologs in other species. We also found that EseN significantly affected mRNA expression of IL-10, pro-apoptotic baxa, and p53, but had no significant effect on anti-apoptotic bcl2 or …

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Increased Lipogenesis Is Important For Hexavalent Chromium-Transformed Lung Cells And Xenograft Tumor Growth, James T.F. Wise, Kazuya Kondo Dec 2023

Increased Lipogenesis Is Important For Hexavalent Chromium-Transformed Lung Cells And Xenograft Tumor Growth, James T.F. Wise, Kazuya Kondo

Faculty Publications

Hexavalent chromium, Cr(VI), is a known carcinogen and environmental health concern. It has been established that reactive oxygen species, genomic instability, and DNA damage repair deficiency are important contributors to the Cr(VI)-induced carcinogenesis mechanism. However, some hallmarks of cancer remain under-researched regarding the mechanism behind Cr(VI)-induced carcinogenesis. Increased lipogenesis is important to carcinogenesis and tumorigenesis in multiple types of cancers, yet the role increased lipogenesis has in Cr(VI) carcinogenesis is unclear. We report here that Cr(VI)-induced transformation of three human lung cell lines (BEAS-2B, BEP2D, and WTHBF-6) resulted in increased lipogenesis (palmitic acid levels), and Cr(VI)-transformed cells had an increased …

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