Digital Commons Network^™

Gasification Of Pelletized Corn Residues With Oxygen Enriched Air And Steam, Poramate Sittisun, Nakorn Tippayawong, Sirivatch Shimpalee

Faculty Publications

This work studied generation of producer gas using oxygen-enriched air and steam mixture as gasifying medium. Corn residues consisting of cobs and stover were used as biomass feedstock. Both corn residues were pelletized and gasified separately with normal air, oxygen enriched air and steam mixture in a fixed bed reactor. Effects of oxygen concentration in enriched air (21-50%), equivalence ratio (0.15-0.35), and steam to biomass ratio (0-0.8) on the yield of product gas, the combustible gas composition such as H2, CO, and CH4, the lower heating value (LHV), and the gasification efficiency were investigated. It was found that the decrease …

Changes In Southeastern Usa Summer Precipitation Event Types Using Instrumental (1940-2018) And Tree-Ring (1790-2018) Data, T.J. Mitchell, P.A. Knapp, T.W. Patterson

Faculty Publications

We examined short- and long-term changes in precipitation event types using instrumental (1940–2018) and tree-ring (1790–2018) data from North Carolina, USA. We documented the amount and frequency of summer (July–September) precipitation events using daily weather station data. Stationary front precipitation (SFP) represented 71% of total summer rainfall and SFP and convective uplift combined (i.e., quasi-stationary precipitation, QSP) represented 87%. SFP (r = 0.52, p < 0.01) and QSP (r = 0.61, p < 0.01) precipitation reconstructions from a montane longleaf pine latewood chronology both recorded significant declines during 1940–2018, matching the instrumental record. Conversely, no significant change in either SFP or QSP occured during the full reconstruction indicating the instrumental decline was unmatched throughout 1790–1939. Our method demonstrates that variations in latewood growth can be attributed to specific precipitation event types and that the relative contribution of each event type can be quantified over a multi-century period.

Repeated Vaginal Exposures To The Common Cosmetic And Household Preservative Methylisothiazolinone Induce Persistent, Mast Cell-Dependent Genital Pain In Nd4 Mice, Erica Arriaga-Gomez, Jacyln Kline, Elizabeth Emanuel, Nefeli Neamonitaki, Tenzin Yangdon, Hayley Zacheis, Dogukan Pasha, Jinyoung Lim, Susan Bush, Beebie Boo, Hanna Mengistu, Ruby Kinnamon, Robin Shields-Cutler, Wattenberg Wattenberg, Devavani Chatterjea

Faculty Publications

A history of allergies doubles the risk of vulvodynia-a chronic pain condition of unknown etiology often accompanied by increases in numbers of vulvar mast cells. We previously established the biological plausibility of this relationship in mouse models where repeated exposures to the allergens oxazolone or dinitrofluorobenzene on the labiar skin or inside the vaginal canal of ND4 Swiss Webster outbred mice led to persistent tactile sensitivity and local increases in mast cells. In these models, depletion of mast cells alleviated pain. While exposure to cleaning chemicals has been connected to elevated vulvodynia risk, no single agent has been linked to …

Comprehensive Second-Order Adjoint Sensitivity Analysis Methodology (2nd-Asam) Applied To A Subcritical Experimental Reactor Physics Benchmark: Ii. Effects Of Imprecisely Known Microscopic Scattering Cross Sections, Daniel Gabriel Cacuci, Ruixian Fang

Faculty Publications

This work continues the presentation commenced in Part I of the second-order sensitivity analysis of nuclear data of a polyethylene-reflected plutonium (PERP) benchmark using the Second-Order Adjoint Sensitivity Analysis Methodology (2nd-ASAM). This work reports the results of the computations of the first- and second-order sensitivities of this benchmark's computed leakage response with respect to the benchmark's 21,600 parameters underlying the computed group-averaged isotopic scattering cross sections. The numerical results obtained for the 21,600 first-order relative sensitivities indicate that the majority of these were small, the largest having relative values of O (10(-2)). Furthermore, the vast majority of the (21600)(2) second-order …

Comprehensive Second-Order Adjoint Sensitivity Analysis Methodology (2nd-Asam) Applied To A Subcritical Experimental Reactor Physics Benchmark: Iii. Effects Of Imprecisely Known Microscopic Fission Cross Sections And Average Number Of Neutrons Per Fission, Dan Gaberiel Cacuci, Ruixian Fang, J. A. Favorite, M. C. Badea, F. Di Rocco

Faculty Publications

The Second-Order Adjoint Sensitivity Analysis Methodology (2nd-ASAM) is applied to compute the first-order and second-order sensitivities of the leakage response of a polyethylene-reflected plutonium (PERP) experimental system with respect to the following nuclear data: Group-averaged isotopic microscopic fission cross sections, mixed fission/total, fission/scattering cross sections, average number of neutrons per fission (), mixed /total cross sections, /scattering cross sections, and /fission cross sections. The numerical results obtained indicate that the 1st-order relative sensitivities for these nuclear data are smaller than the 1st-order sensitivities of the PERP leakage response with respect to the total cross sections but are larger than those …

Oyster Reefs In Northern Gulf Of Mexico Estuaries Harbor Diverse Fish And Decapod Crustacean Assemblages: A Meta-Synthesis, Megan K. La Peyre, Danielle Aguilar Marshall, Lindsay S. Miller

Faculty Publications

Oyster reefs provide habitat for numerous fish and decapod crustacean species that mediate ecosystem functioning and support vibrant fisheries. Recent focus on the restoration of eastern oyster (Crassostrea virginica) reefs stems from this role as a critical ecosystem engineer. Within the shallow estuaries of the northern Gulf of Mexico (nGoM), the eastern oyster is the dominant reef building organism. This study synthesizes data on fish and decapod crustacean occupancy of oyster reefs across nGoM with the goal of providing management and restoration benchmarks, something that is currently lacking for the region. Relevant data from 23 studies were identified, representing data …

Genomic Selection In Rubber Tree Breeding: A Comparison Of Models And Methods For Managing G×E Interactions, Livia M. Souza, Felipe R. Francisco, Paulo S. Gonçalves, Erivaldo J. Scaloppi Junior, Vincent Le Guen, Roberto Fritsche-Neto, Anete P. Souza

Faculty Publications

Several genomic prediction models combining genotype × environment (G×E) interactions have recently been developed and used for genomic selection (GS) in plant breeding programs. G×E interactions reduce selection accuracy and limit genetic gains in plant breeding. Two data sets were used to compare the prediction abilities of multienvironment G×E genomic models and two kernel methods. Specifically, a linear kernel, or GB (genomic best linear unbiased predictor [GBLUP]), and a nonlinear kernel, or Gaussian kernel (GK), were used to compare the prediction accuracies (PAs) of four genomic prediction models: 1) a single-environment, main genotypic effect model (SM); 2) a multienvironment, main …

First Principles Investigation Of Anomalous Pressure-Dependent Thermal Conductivity Of Chalcopyrites, Loay Flalfy, Denis Music, Ming Hu

Faculty Publications

The effect of compression on the thermal conductivity of CuGaS2, CuInS2, CuInTe2, and AgInTe2 chalcopyrites (space group I-42d) was studied at 300 K using phonon Boltzmann transport equation (BTE) calculations. The thermal conductivity was evaluated by solving the BTE with harmonic and third-order interatomic force constants. The thermal conductivity of CuGaS2 increases with pressure, which is a common behavior. Striking differences occur for the other three compounds. CuInTe2 and AgInTe2 exhibit a drop in the thermal conductivity upon increasing pressure, which is anomalous. AgInTe2 reaches a very low thermal conductivity of 0.2 W·m−1 ·K −1 at 2.6 GPa, being beneficial …

Molecular Properties Are A Primary Control On The Microbial Utilization Of Dissolved Organic Matter In The Ocean, Yuan Shen, Ronald Benner

Faculty Publications

The global ocean sequesters a large amount of reduced carbon in dissolved organic molecules that can persist for centuries to millennia. The persistence of dissolved organic carbon (DOC) in the deep ocean has been attributed to inherently refractory molecules and to low concentrations of molecules, but the relative roles of molecular properties and molecular concentrations remain uncertain. We investigate both of these possibilities using bioassay experiments with unfiltered seawater collected from five depths (50–1500 m) at the Bermuda Atlantic TimeSeries Study site. The microbial utilization of compositionally distinct forms of seawater DOC at in situ and elevated concentrations was determined. …

Cross-Linked Poly(4-Vinylpyridine-N-Oxide) As A Polymer-Supported Oxygen Atom Transfer Reagent, Anna M. Bauer, Erin E. Ramey, Kjersti G. Oberle, Gretchen A. Fata, Chloe D. Hutchison, Christopher R. Turlington

Faculty Publications

Oxygen atom transfer (OAT) reagents are common in biological and industrial oxidation reactions. While many heterogeneous catalysts have been utilized in OAT reactions, heterogeneous OAT reagents have not been explored. Here, cross-linked poly(4-vinylpyridine-N-oxide), called x-PVP-N-oxide, was tested as a heterogeneous OAT reagent and its oxidation chemistry compared to its molecular counterpart, pyridine-N-oxide. The insoluble oxidant x-PVP-N-oxide demonstrated comparable reactivity to pyridine-N-oxide in direct oxidation reactions of phosphines and phosphites in acetonitrile, but x-PVP-N-oxide did not react in other solvents. The polymer backbone of x-PVP-N-oxide, however, allowed …

Direct Neutron Capture Cross Section On Ge 80 And Probing Shape Coexistence In Neutron-Rich Nuclei, S. Ahn, D. W. Bardayan, K. L. Jones, A. S. Adekola, G. Arbanas, J. C. Blackmon, K. Y. Chae, K. A. Chipps, J. A. Cizewski, S. Hardy, M. E. Howard, R. L. Kozub, B. Manning, M. Matoš, C. D. Nesaraja, P. D. O'Malley, S. D. Pain, W. A. Peters, S. T. Pittman, B. C. Rasco, M. S. Smith, I. Spassova

Faculty Publications

Results are presented from the first neutron-transfer measurement on Ge80 using an exotic beam from the Holifield Radioactive Ion Beam Facility at Oak Ridge National Laboratory. Newly measured spins and spectroscopic factors of low-lying states of Ge81 are determined, and the neutron capture cross section on Ge80 was calculated in a direct-semidirect model to provide a more realistic (n,γ) reaction rate for r-process simulations. Furthermore, a region of shape coexistence around N≈50 is confirmed and implications for the magic nature of Ni78 are discussed.

Core–Shell Nanospheres Behind The Blue Eyes Of The Bay Scallop Argopecten Irradians, Olivia K. Harris, Alexandra C.N. Kingston, Caitlin S. Wolfe, Soumitra Ghoshroy, Sönke Johnsen, Daniel Isaac Speiser

Faculty Publications

The bay scallop Argopecten irradians (Mollusca: Bivalvia) has dozens of iridescent blue eyes that focus light using mirror-based optics. Here, we test the hypothesis that these eyes appear blue because of photonic nanostructures that preferentially scatter short-wavelength light. Using transmission electron microscopy, we found that the epithelial cells covering the eyes of A. irradians have three distinct layers: an outer layer of microvilli, a middle layer of random close-packed nanospheres and an inner layer of pigment granules. The nanospheres are approximately 180 nm in diameter and consist of electron-dense cores approximately 140 nm in diameter surrounded by less electron-dense shells …

Lorentz- And C P T -Violating Standard Model Extension In Chiral Perturbation Theory, Brett Altschul, Matthias R. Schindler

Faculty Publications

Lorentz and CPT violation in hadronic physics must be tied to symmetry violations at the underlying quark and gluon level. Chiral perturbation theory provides a method for translating novel operators that may appear in the Lagrange density for color-charged parton fields into equivalent forms for effective theories at the meson and baryon levels. We extend the application of this technique to the study of Lorentzviolating and potentially CPT-violating operators from the minimal standard model extension. For dimension-4 operators, there are nontrivial relations between the coefficients of baryon-level operators related to underlying quark and gluon operators with the same Lorentz structures. …

The Association Between Dietary Inflammatory Index (Dii) And Cancer Risk In Korea: A Prospective Cohort Study Within The Koges-Hexa Study, Injeong Ryu, Minji Kwon, Cheongmin Sohn, Nitin Shivappa, James R. Hébert, Woori Na, Mi Kyung Kim

Faculty Publications

Several epidemiological studies have shown that there are consistently positive associations between dietary inflammatory index (DII (R)) scores and cancer incidence in Western populations. However, few DII-cancer studies have been conducted in East Asian populations. In a large cohort representative of the general Korean population, we investigated whether the DII is associated with overall cancer risk. A total of 163,660 participants (56,781 males and 106,879 females) had evaluable data for analyses. This follow-up study was carried out over the course of 7.9 years. DII scores were calculated based on Semi-Quantitative Food-Frequency Questionnaire (SQ-FFQ) data for 106 food items. Cancers were …

Upcycling Single-Use Polyethylene Into High-Quality Liquid Products, Gokhan Celik, Robert M. Kennedy, Ryan A. Hackler, Magali Ferrandon, Akalanka Tennakoon, Smita Patnaik, Anne M. Lapointe, Salai Ammal, Andreas Heyden, Frédéric A. Perras, Marek Pruski, Susannah L. Scott, Kenneth R. Poeppelmeier, Aaron D. Sadow, Massimiliano Delferro

Faculty Publications

Our civilization relies on synthetic polymers for all aspects of modern life; yet, inefficient recycling and extremely slow environmental degradation of plastics are causing increasing concern about their widespread use. After a single use, many of these materials are currently treated as waste, underutilizing their inherent chemical and energy value. In this study, energy-rich polyethylene (PE) macromolecules are catalytically transformed into value-added products by hydrogenolysis using well-dispersed Pt nanoparticles (NPs) supported on SrTiO3 perovskite nanocuboids by atomic layer deposition. Pt/SrTiO3 completely converts PE (Mn = 8000− 158,000 Da) or a single-use plastic bag (Mn = 31,000 Da) into high-quality liquid …

Send The Right Message: The Dos And Don’Ts Of Color In Data Visualization, Joseph A. Stanley, Meagan Duever

Faculty Publications

Three dimensions of color

• hue, lightness, and saturation
• Hue = color
• Lightness - measures the relative degree of black or white that’s been mixed with a given hue. Adding white makes the color lighter (creates tints) and adding black makes it darker (creates shades).
• Saturation - how pure or intense a color is; the more saturated a color, the more vivid or brighter it appears

Hydrologic Modeling As A Service (Hmaas): A New Approach To Address Hydroinformatic Challenges In Developing Countries, Michael A. Souffront Alcantara, E. James Nelson, Kiran Shakya, Christopher Edwards, Wade Roberts, Corey Krewson, Daniel P. Ames, Norman L. Jones, Angelica Gutierrez

Faculty Publications

Hydrologic modeling can be used to aid in decision-making at the local scale. Developed countries usually have their own hydrologic models; however, developing countries often have limited hydrologic modeling capabilities due to factors such as the maintenance, computational costs, and technical capacity needed to run models. A global streamflow prediction system (GSPS) would help decrease vulnerabilities in developing countries and fill gaps in areas where no local models exist by providing extensive results that can be filtered for specific locations. However, large-scale forecasting systems come with their own challenges. These New hydroinformatic challenges can prevent these models from reaching their …

An Open-Source Tool To Facilitate The Processing Of Grace Observations And Gldas Outputs: An Evaluation In Bangladesh, Adam J. Purdy, Cédric H. David, Md. Safat Sikder, John T. Reager, Hrishikesh A. Chandanpukar, Norman L. Jones, Mir A. Matin

Faculty Publications

Bangladesh lies at the intersection of the Ganges, Brahmaputra, and Meghna rivers with a combined average discharge of 38,000 m3s−1 ranking fourth globally. Despite the volume of water flowing through and seasonally inundating parts of the landscape, groundwater reliance is necessary to support an intensive agricultural industry. Here we use newly-developed open-source software to combine observations from the Gravity Recovery and Climate Experiment (GRACE) satellites with hydrologic estimates of land water storage from the Global Land Assimilation Data System (GLDAS) to isolate basin-scale groundwater anomalies in Northwest Bangladesh from 2002 to 2016. We place our estimates in the context of …

Purification Of Tag-Free Chlamydia Trachomatis Scc4 For Structural Studies Using Sarkosyl-Assisted On-Column Complex Dissociation, Thilini O. Ukwaththage, Octavia Y. Goodwin, Abigael C. Songok, Alexa M. Tafaro, Li Shen, Megan A. Macnaughtan

Faculty Publications

Copyright © 2019 American Chemical Society. Chlamydia trachomatis is an obligate intracellular bacterial pathogen that causes the most common sexually transmitted bacterial disease in the world. The bacterium has a unique biphasic developmental cycle with a type III secretion system (T3SS) to invade host cells. Scc4 is a class I T3SS chaperone forming a heterodimer complex with Scc1 to chaperone the essential virulence effector, CopN. Scc4 also functions as an RNA polymerase binding protein to regulate σ66-dependent transcription. Aggregation and low solubility of 6X-histidine-tagged Scc4 and the insolubility of 6X-histidine and FLAG-tagged Scc1 expressed in Escherichia coli have hindered the …

The Importance Of Relationship Processes For Lowering Bmi Over Time In Women With Type 2 Diabetes In A Randomized Controlled Trial, Jeremy B. Yorgason, Jonathan G. Sandberg, Ruth S. Weinstock, Paula M. Trief, Lawrence Fisher, Danielle Hessler

Faculty Publications

Objective: Weight change may be affected by dyadic processes within couple relationships. The aim of this secondary data analysis was to explore trends in BMI across time, and assess whether relationship processes (i.e., relationship satisfaction, positive problem-solving), predict BMI trajectories in men and women.

Methods: Data are from 268 participants in the Diabetes Support Project, a randomized trial of behavioral intervention for individuals with type 2 diabetes (T2D) in poor glycemic control. For secondary analyses, BMI was measured at pre-treatment (baseline), 4 months (post-treatment), 8 months, and 12 months. Multiple relationship variables were measured at all time points and were …

Flight Muscles Degenerate By Programmed Cell Death After Migration In The Wheat Aphid, Sitobion Avenae, Honglin Feng, Xiao Guo, Hongyan Sun, Shuai Zhang, Jinghui Xi, Jiao Yin, Yazhong Cao, Kebin Li

Faculty Publications

Objective: Previous studies showed that flight muscles degenerate after migration in some aphid species; however, the underlying molecular mechanism remains virtually unknown. In this study, using the wheat aphid, Sitobion avenae, we aim to investigate aphid flight muscle degeneration and the underlying molecular mechanism. Results: Sitobion avenae started to differentiate winged or wingless morphs at the second instar, the winged aphids were fully determined at the third instar, and their wings were fully developed at the fourth instar. After migration, the aphid flight muscles degenerated via programmed cell death, which is evidenced by a Terminal deoxynucleotidyl transferase dUTP-biotin nick-end labeling …

Gut Dna Virome Diversity And Its Association With Host Bacteria Regulate Inflammatory Phenotype And Neuronal Immunotoxicity In Experimental Gulf War Illness, Ratanesh K. Seth, Rabia Maqsood, Ayan Mondal, Dipro Bose, Diana Kimono, Larinda A. Holland, Patricia Janulewicz Lloyd, Nancy Klimas, Ronnie Horner, Kimberly Sullivan, Efrem S. Lim, Saurabh Chatterjee

Faculty Publications

Gulf War illness (GWI) is characterized by the persistence of inflammatory bowel disease, chronic fatigue, neuroinflammation, headache, cognitive impairment, and other medically unexplained conditions. Results using a murine model show that enteric viral populations especially bacteriophages were altered in GWI. The increased viral richness and alpha diversity correlated positively with gut bacterial dysbiosis and proinflammatory cytokines. Altered virome signature in GWI mice also had a concomitant weakening of intestinal epithelial tight junctions with a significant increase in Claudin-2 protein expression and decrease in ZO1 and Occludin mRNA expression. The altered virome signature in GWI, decreased tight junction protein level was …

Search For Subsolar Mass Ultracompact Binaries In Advanced Ligo’S Second Observing Run, Tiffany Summerscales, Ligo Scientific Collaboration And The Virgo Collaboration

Faculty Publications

We present a search for subsolar mass ultracompact objects in data obtained during Advanced LIGO’s second observing run. In contrast to a previous search of Advanced LIGO data from the first observing run, this search includes the effects of component spin on the gravitational waveform. We identify no viable gravitational-wave candidates consistent with subsolar mass ultracompact binaries with at least one component between 0.2  M_⊙–1.0  M_⊙. We use the null result to constrain the binary merger rate of (0.2  M_⊙, 0.2  M_⊙) binaries to be less than 3.7×10⁵  Gpc⁻³ yr …

Search For Subsolar Mass Ultracompact Binaries In Advanced Ligo's Second Observing Run, B. P. Abbott, R. Abbott, T. D. Abbott, S. Abraham, F. Acernese, K. Ackley, C. Adams, R. X. Adhikari, V. B. Adya, C. Affeldt, M. Agathos, K. Agatsuma, N. Aggarwal, O. D. Aguiar, L. Aiello, A. Ain, P. Ajith, G. Allen, A. Allocca, M. A. Aloy, P. A. Altin, A. Amato, S. Anand, A. Ananyeva, S. B. Anderson, W. G. Anderson, S. V. Angelova, S. Antier, S. Appert, K. Arai, M. C. Araya, J. S. Areeda, M. Arène

Faculty Publications

We present a search for subsolar mass ultracompact objects in data obtained during Advanced LIGO's second observing run. In contrast to a previous search of Advanced LIGO data from the first observing run, this search includes the effects of component spin on the gravitational waveform. We identify no viable gravitational-wave candidates consistent with subsolar mass ultracompact binaries with at least one component between 0.2 Ma-1.0 Ma. We use the null result to constrain the binary merger rate of (0.2 M, 0.2 M) binaries to be less than 3.7×105 Gpc-3 yr-1 and the binary merger rate of (1.0 M, 1.0 M) …

Considering "Atmosphere" When Facilitating Information Seeking By People With Invisible Disabilities In Public Libraries, Rebecca Muir, Kim M. Thompson, Asim Qayyum

Faculty Publications

Twenty percent of Australians reported having a disability in 2015. Disability may occur at any time during the lifespan, however most disabilities are invisible. When a disability is invisible, or not immediately apparent to an outsider, individuals may need to self-identify to access inclusive services, or accommodation may never be offered at all.

When the perceived number of information seekers with a disability is low, information organisations may deem services unnecessary. Considering information access is a human right, information service providers and researchers need to seek low cost and low effort ways to facilitate information access and information seeking behaviors. …

Experimental And Computational Electrochemistry Of Quinazolinespirohexadienone Molecular Switches – Differential Electrochromic Vs Photochromic Behavior, Eric W. Webb, Jonathan P. Moerdyk, Kyndra B. Sluiter, Benjamin J. Pollock, Amy L. Speelman, Eugene J. Lynch, William F. Polik, Jason G. Gillmore

Faculty Publications

Our undergraduate research group has long focused on the preparation and investigation of electron-deficient analogs of the perimidinespirohexadienone (PSHD) family of photochromic molecular switches for potential application as "photochromic photooxidants" for gating sensitivity to photoinduced charge transfer. We previously reported the photochemistry of two closely related and more reducible quinazolinespirohexadienones (QSHDs), wherein the naphthalene of the PSHD is replaced with a quinoline. In the present work, we report our investigation of the electrochemistry of these asymmetric QSHDs. In addition to the short wavelength and photochromic long-wavelength isomers, we have found that a second, distinct long-wavelength isomer is produced electrochemically. This …

Abstraction, Filtration, And Comparison In Patent Law, Michael Risch

Faculty Publications

https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3232508

Understanding And Use Of Food Labeling Systems Among Whites And Latinos In The United States And Among Mexicans: Results From The International Food Policy Study, 2017, Claudia Nieto, Alejandra Jauregui, Alejandra Contreras-Manzano, Edna Arillo-Santillan, Simon Barquera, Christine M. White, David Hammond, Jim Thrasher

Faculty Publications

Background Obesity and chronic diseases could be prevented through improved diet. Most governments require at least one type of food labeling system on packaged foods to communicate nutrition information and promote healthy eating. This study evaluated adult consumer understanding and use of nutrition labeling systems in the US and Mexico, the most obese countries in the world.

Methods Adults from online consumer panels in the US (Whites n = 2959; Latinos n = 667) and in Mexico (n = 3533) were shown five food labeling systems: 1. Nutrition Facts Table (NFT) that shows nutrients of concern per serving; 2. Guideline …

Superior Colliculus Lesions Lead To Disrupted Responses To Light In Diurnal Grass Rats (Arvicanthis Niloticus), Andrew J. Gall, Alyssa M. Goodwin, Ohanes S. Khacherian, Laura B. Teal

Faculty Publications

The circadian system regulates daily rhythms of physiology and behavior. Although extraordinary advances have been made to elucidate the brain mechanisms underlying the circadian system in nocturnal species, less is known in diurnal species. Recent studies have shown that retinorecipient brain areas such as the intergeniculate leaflet (IGL) and olivary pretectal nucleus (OPT) are critical for the display of normal patterns of daily activity in diurnal grass rats (Arvicanthis niloticus). Specifically, grass rats with IGL and OPT lesions respond to light in similar ways to intact nocturnal animals. Importantly, both the IGL and OPT project to one another …

Circulating Obesity-Driven Biomarkers Are Associated With Risk Of Clear Cell Renal Cell Carcinoma: A Two-Stage, Case-Control Study, Qinchuan Wang, Huakang Tu, Meiling Zhu, Dong Liang, Yuanqing Ye, David W. Chang, Yin Long, Xifeng Wu

Faculty Publications

Obesity is one of modifiable risk factors for clear cell renal cell cancer (ccRCC). We aim to identify the association between obesity-driven biomarkers and ccRCC risk. This is a retrospective, two-phase, case-control study involving 682 cases and 733 controls. Obesity-driven biomarkers [gastric inhibitory polypeptide (GIP), C-peptide, insulin, resistin, adipsin, peptide YY, pancreatic polypeptide, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), plasminogen activator inhibitor-1, monocyte chemoattractant protein 1, lipocalin2, leptin, adiponectin] were measured using the Milliplex method. Multivariate logistic regression was used to assess the associations between biomarkers and ccRCC risk. Results revealed that GIP, C-peptide, IL-6 and TNF-α levels were consistently …