Digital Commons Network^™

Reformulation Of The Protein Databank For Real-Time Search Of Geometrical Attributes Of Protein Structures, Musa Azeem, Christopher Lee, Aaron Hein, Christopher Ott, Homayoun Valafar

Faculty Publications

Introduction:

In this study, we introduce the design and implementation of PDBMine, a large-scale, queryable platform for mining sequence-structure statistics from the Protein Data Bank (PDB). PDBMine enables rapid analysis of local conformational trends across proteins by extracting dihedral angles and sequence patterns at scale. In addition to the design and implementation of PDBMine, we also present results validating its ability to return structurally meaningful information.

Methods:

We first assess the accuracy of its dihedral angle distributions by comparing them to established Ramachandran space and verifying expected behaviors of residues such as glycine and proline. We then use PDBMine to …

Temperature Dependent High Frequency Performance Of A 62% Algan Channel Hemt, Jiahao Chen, Abdullah Al Mamun Mazumder, Parthasarathy Seshadri, Dheekshinn Nandakumar, Ruixin Bai, Rafael Andrew Choudhury, M. Asif Khan, Chirag Gupta

Faculty Publications

This article reports on the temperature dependent performance of a HEMT with an Al_0.62Ga_0.38N channel layer and an Al_0.84Ga_0.16N barrier layer grown by metal–organic chemical vapor deposition. The device in this report was measured at room temperature and elevated temperatures of 100–150 °C. The sheet resistance increased from 3.5 kΩ/sq (25 °C) to 5.4 kΩ/sq (150 °C), while the contact resistance remained nominally similar. For a device with 160 nm gate length and 2 µm source-to-drain length, excellent electrical characteristics have been achieved when the device was operated at 150 °C with …

Optimal Placement Of Electric Vehicle Chargers: A Mixed-Integer Linear Programming Model, Joubin Zahiri Khameneh, Emmanuel Fagbenle

Faculty Publications

Electric vehicle adoption is growing, but New Hampshire lags in public charging infrastructure, especially in rural areas. This gap increases range anxiety and economic inefficiencies. In this study, we developed a mixed-integer linear programming (MILP) model to optimally locate new electric vehicle chargers statewide, maximizing coverage and equity under budget constraints. The model includes geographic coverage requirements, population-weighted equity, capacity limits, and a $28 million budget. Moreover, the model recommends 855 Level 2 chargers and 149 Direct Current Fast Chargers (DCFCs) across 247 ZIP Codes, nearly doubling public charging capacity and achieving 98.8% coverage within defined service radii. The plan …

Flux Crystal Growth Of Potassium Lanthanide Double Vanadates With Lanthanide-Dependent Coordination Number Variance, Hunter B. Tisdale, Hans Conrad Zur Loye

Faculty Publications

A series of potassium rare earth double vanadates is presented. Single crystals of double vanadates with stoichiometry K₃Ln(VO₄)₂ (Ln = La, Pr, Nd, and Sm) and crystallizing in the glaserite structure type were synthesized via a molten alkali chloride/fluoride flux reaction. Different structures were observed depending on the constituent rare earth: K₃La(VO₄)₂ crystallizes in an as-of-yet unreported modification of the typical glaserite structure in the space group P2₁/c, likely due to its larger ionic size that results in an increase in the lanthanide coordination number …

Precision Acoustofluidics For High-Throughput Mechanobiology In Suspension Cells, Kaichun Yang, Ruoyu Zhong, Ke Li, John Mai, Pengzhan Liu, Ye He, Joseph Rich, Ying Chen, Janna Wang, Zhiteng Ma, Zhiteng Ma, Xianchen Xu, Qian Wu, Tony Jun Huang

Faculty Publications

Mechanomodulation, the process of altering cellular behavior through applied mechanical forces, plays a critical role in physiological processes and has substantial implications for cancer therapy, immunology, and drug development. However, precise and efficient stimulation of nonadherent cells remains a major challenge, limiting the investigation of mechanotransduction pathways and the development of targeted therapeutics. Here, we developed an acoustofluidic platform named Suspension-cell Targeted Response to Excitation via Acoustofluidic Mechanomodulation (STREAM) to enable precise, high-throughput stimulation of suspension cells. STREAM accomplishes this using 101.14-megahertz high-frequency surface acoustic waves to deliver controlled mechanical stimulation at a throughput of 500,000 cells per minute. STREAM …

Legacy Phosphorus Dynamics In Subtropical River Sediments: Impacts Of Dredging And Water Column Aeration Status, Lee Potter, John R. White

Faculty Publications

Excessive loading of phosphorus (P) in coastal systems has been a growing concern for watershed managers due to the link with harmful algal blooms. In particular, legacy P creates a persistent challenge for eutrophication management in a range of aquatic systems, including wetlands, lakes, and estuaries, as a source of indirect, internal P loading. Following reductions in external P loads, internal sediment sources have been known to release bioavailable P back into the water column, undermining nutrient restoration goals. This study investigates the flux dynamics and longevity of sediment legacy P in three subtropical rivers—Amite, Tangipahoa, and Tickfaw—draining into the …

Increasing Wave Heights In The Gulf Of Mexico Driven By Swell Waves, Jesbin George, Matthew Hiatt, Clinton S. Willson

Faculty Publications

This study analyzes the climatology, spatial and temporal trends of wind speeds and significant wave height (Hs) of combined wind-seas and swells and Hs of separated swells and wind-seas on annual and seasonal scales in the Gulf of Mexico (GoM) using 50 years of atmospheric reanalysis data. The Hs data showed strong agreement with in-situ measurements, with minimal bias (+/-< 0.08 m) and high correlation (r > 0.9) across both deep and shallow regions, although a slight underestimation is noted for wind speed data. Wind speeds showed seasonal variability in the GoM, though they did not exhibit significant long-term increases, except for a notable decrease (~ -1.0 …

Access To Primary Care And Health Care Fragmentation, Sharona Hoffman, Ishani Ganguli

Faculty Publications

This Article examines the growing crisis of long primary care wait times and the health care fragmentation that is associated with them. Patients who feel ill or are worried about new symptoms must often wait weeks or longer for appointments. In the wake of excessive wait times for primary care physician (PCP) appointments, patients increasingly turn to convenience care models such as urgent care centers, retail clinics, direct-to-consumer telemedicine, and at-home testing. While these alternatives offer prompt attention, they sacrifice other core functions of primary care and may exacerbate poor health outcomes and inequities. The Article argues that long wait …

Rosenwald Rural School Libraries, Suzanne Marie Stauffer

Faculty Publications

The Rosenwald Rural School Libraries Program was created as an adjunct to the Rosenwald Rural Schools Program, which funded the construction of 4,977 rural Black school buildings in fifteen Southern states, 395 of them in Louisiana. However, it soon became apparent that providing textbooks was not enough to promote literacy and develop self-directed reading among students. The officers and agents of the Fund realized fairly early in the Rural Schools Program that there was a want of reading materials in the South in general. Beginning in 1927, the Rosenwald Fund began providing collections of graded fiction and non-fiction books to …

Stoichiometry-Controlled Surface Reconstructions In Epitaxial Abo3 Perovskites For Sustainable Energy Applications, Habib Rostaghi Chalaki, Ebenezer Seesi, Gene Yang, Mohammad El Loubani, Dongkyu Lee

Faculty Publications

ABO₃ perovskite oxides are a versatile class of materials whose surfaces and interfaces play essential roles in sustainable energy technologies, including catalysis, solid oxide fuel and electrolysis cells, thermoelectrics, and energy-relevant oxide electronics. The interplay between point defects and surface reconstructions strongly affects interfacial stability, charge transport, and catalytic activity under operating conditions. This review summarizes recent progress in understanding how oxygen vacancies, cation nonstoichiometry, and electronic defects couple to atomic-scale surface rearrangements in representative perovskite systems. We first revisit Tasker’s classification of ionic surfaces and clarify how defect chemistry provides compensation mechanisms that stabilize otherwise polar or metastable …

Reinforcement Learning-Enabled Control And Design Of Rigid-Link Robotic Fish: A Comprehensive Review, Nhat Dinh, Darion Vosbein, Yuehua Wang, Qingsong Cui

Faculty Publications

With the rising demand for maritime surveys of infrastructure, energy resources, and environmental conditions, autonomous robotic fish have emerged as a promising solution with their biomimetic propulsion, agile motion, efficiency, and capacity for underwater inspection, monitoring, data collection, and exploration tasks in complex aquatic environments. Inspired by fish spines, rigid-link fish robots (RLFRs), a category of robotic fish, are widely utilized in robotics research and applications. Their rigid, actuated joints enable them to reproduce the undulatory locomotion and high maneuverability of biological fishes, while the modular nature of rigid links between joints makes them cost-effective and easy to assemble. This …

Navigating Racist Spaces Through Radical Self-Care: A Photovoice Exploration Of The Experiences Of Black Graduate Students, Laetitia Adelson, Cherese Fine, Dion Harry, Keneisha Harrington, Rebecca Lynn Morgan Ph.D., Tomiko Smalls, Jerad Green, Courtney Allen, Anuoluwapo Bankole, Robin Phelps-Ward

Faculty Publications

This manuscript examines the impact of racist campus climates for Black graduate students at a predominantly white institution. Using a photovoice methodological design, this study illuminates students’ ability to thrive through radical self-care despite the many racist factors, incidents, and systems at the institution. The paper ends with recommendations for improving campus racial climate in graduate education.

Hydrodynamic Tipping Points In The Mississippi Sound In Response To Bonnet Carré Spillway Openings, Mustafa Kemal Cambazoglu, Brandy N. Armstrong, Mohsena Lopa, Marc Diard, Jerry D. Wiggert

Faculty Publications

This project examines the current operational strategy of the Bonnet Carré Spillway (BCS), a Mississippi River flood-control structure located about 21 miles northwest of New Orleans, Louisiana, and managed by the U.S. Army Corps of Engineers. The BCS is part of the larger Mississippi River and Tributaries Project, a network of levees and control structures designed to minimize flooding from the American plains to southern Louisiana. The spillway is opened when river discharge at New Orleans is forecasted to exceed 1,250,000 cubic feet per second, diverting significant volumes of Mississippi River water into Lake Pontchartrain which subsequently flows into Mississippi …

Ecological Tipping Points In The Mississippi Sound In Response To Modeled Bonnet Carré Spillway Openings, Kim De Mutsert, Aaron Ridall, Scott Milroy

Faculty Publications

This project examines ecological effects of the current operational strategy of the Bonnet Carré Spillway (BCS), a Mississippi River flood-control structure located about 21 miles northwest of New Orleans, Louisiana, and managed by the U.S. Army Corps of Engineers. The BCS is part of the larger Mississippi River and Tributaries Project, a network of levees and control structures designed to minimize flooding from the American plains to southern Louisiana. The spillway is opened when river discharge at New Orleans is forecasted to exceed 1,250,000 cubic feet per second, diverting significant volumes of Mississippi River water into the Mississippi Sound. The …

Convergence Of High Throughput Experimentation And Machine Learning To Rapidly Advance Application-Specific Polymer Development, Mashrafee Aryan, Daniel Struble, Felix Campbell, Saroj Upreti, S. M.Ashik Abedin, Aahil Khambawla, Jeetain Mittal, Michael S. Dimitriyev, Emily B. Pentzer, Svetlana A. Sukhishvili, Xiaodan Gu, Boran Ma

Faculty Publications

Machine learning (ML) has heavily influenced the way scientific study is done with demonstrated successes in nearly every field. However, furthering performance and explainability of ML models in increasingly complex systems and with increasingly demanding outcomes requires a significant influx of high-quality data. To that end, this Review covers some of the techniques, instrumentation, and methodologies that have shown promise for significantly accelerating the discovery of polymer materials, optimization of their properties, and elucidation of property–application relationships through high throughput (HT) experimentation, characterization, and analysis. Attention is given to not only ML, but also to hardware advancements and their synergy …

A Comprehensive Survey On Facial Expression Generation: From Gans To Llm-Guided Multimodal Models, Murad Hasan, Rabab Abdelfattah, Kareem Abdelfatah, Mostafa Fouda, Ahmed Sherif

Faculty Publications

Facial expression generation (FEG) has emerged as a vital area in human–computer interaction, virtual avatars, and affective computing, aiming to synthesize natural and expressive facial behaviors across diverse interaction contexts. This survey presents a comprehensive analysis of recent advances in FEG, organized into six key paradigms: speech-driven expression generation, facial reaction generation, face video generation, facial animation, avatar-based generation, and text-driven expression generation. We review a wide range of model architectures, including VQ-VAEs, Generative Adversarial Networks (GANs), 3D Morphable Models (3DMMs), Transformers, and diffusion-based approaches, and compare their performance using commonly adopted evaluation metrics such as Fréchet Distance (FD), Peak …

Using Network Models To Understand Biological Signaling Architecture, Russ White, Emily Brown Reeves, Gerald L. Fudge

Faculty Publications

Engineers have developed abstract network models to better understand the recurring problems faced by communication systems. This paper argues that these models can be generalized to describe biological communications systems given that they share many requirements with human-designed systems, including functional requirements and physical constraints. Leveraging collaboration, biologists and engineers can work together to use well-understood communication systems, designed to carry data across a computer network, as a model for analyzing less well-understood biological communication systems in order to make predictions and uncover previously unknown functionalities. To illustrate this approach, we apply the Recursive Internet Network Architecture model (RINA) to …

Pullulan Production From Lignocellulosic Plant Biomass Or Starch-Containing Processing Coproduct Hydrolysates, Thomas P. West

Faculty Publications

The complex polysaccharide pullulan is characterized as a glucose-containing biopolymer that is both water-soluble and neutral in polarity. A variety of commercial applications exist for pullulan, including its utilization as a flocculant, a blood plasma substitute, a food additive, a dielectric material, an adhesive, or a packaging film. The fungus Aureobasidium pullulans has used several hydrolysates derived from plant biomass or starch-containing processing coproducts to support polysaccharide production. These include various plant biomass or processing coproduct streams such as lignocellulosic-containing peat, prairie grass, stalks, hulls, straw, shells, and pods or starch-containing coproducts from the processing of corn, rice, jackfruit seeds, …

Performance Of Shcc Brick Infill And Nsm Reinforcement Systems For Strengthening Rc Deep Beams With Large Openings, Ahmed Badr El-Din, Mohamed Ghalla, Galal Elsamak, Ayman El-Zohairy

Faculty Publications

The presence of large web openings in reinforced concrete (RC) deep beams often disrupts the natural load-transfer mechanism, leading to severe reductions in shear strength and premature failure. This study introduces a novel hybrid strengthening system incorporating strain-hardening cementitious composite (SHCC) bricks, stainless-steel and galvanized-steel sheets, and near-surface-mounted (NSM) steel reinforcements to restore and enhance the shear performance of RC deep beams with large openings. A comprehensive experimental program was conducted on sixteen beams under concentrated loading to evaluate the influence of different infill and strengthening configurations on load capacity, stiffness, ductility, and energy absorption. The results revealed that the …

Firearms And Fora: Constructing Public Carry Doctrine, Timothy Zick

Faculty Publications

Where can a person lawfully carry firearms in public? Under what conditions can they do so? Now that the Supreme Court has formally recognized a Second Amendment right to public carry, these are among the most important unresolved questions regarding the right to bear arms. The Second Amendment’s public carry doctrine is in its infancy. How the doctrine develops will have a profound impact on the exercise of Second Amendment rights in public places and on the public square. Integrating a new constitutional right into the public square is not a novel problem. After the Supreme Court recognized First Amendment …

Developer Perspectives On Licensing And Copyright Issues Arising From Generative Ai For Software Development, Trevor Stalnaker, Nathan Wintersgill, Oscar Chaparro, Laura A. Heymann, Massimiliano Di Penta, Daniel M. German, Denys Poshyvanyk

Faculty Publications

Despite the utility that Generative AI (GenAI) tools provide for tasks such as writing code, the use of these tools raises important legal questions and potential risks, particularly those associated with copyright law. As lawmakers and regulators respond to these questions, the views of users can offer relevant perspectives. In this article, we provide: (1) a survey of 574 developers on the licensing and copyright aspects of GenAI for coding, as well as follow-up interviews; (2) a snapshot of developers’ views at a time when GenAI and perceptions of it were rapidly evolving; and (3) an analysis of developers’ perspectives, …

Serum Protein Signatures For Breast Cancer Detection In Treatment-Naïve African American Women Using Integrated Proteomics And Pattern Analysis, Padma Tadi Uppala, Elmer Rivera, Hyun J. Kwon, Sharon S. Lum

Faculty Publications

Breast cancer is the leading cause of cancer-related mortality in African American (AA) women. In this study we evaluated the serum proteomic profile of AA women with breast cancer using an integrated proteomic framework with multivariate pattern analysis. Using 2D-DIGE, thousands of serum protein spots were detected across 33 gels; 46 spots met criteria for presence, statistical significance, and differential expression. Proteins from the spots were identified by MALDI-TOF/TOF and matched in curated databases, highlighting serum biomarkers including ceruloplasmin, alpha-2-macroglobulin, complement component C3 and C6, alpha-1-antitrypsin, alpha-1B-glycoprotein, alpha-2-HS-glycoprotein and haptoglobin-related protein. LC-MS/MS analysis revealed 163 differentiating peptides after imputing and …

Audit Guides And The Administrative State, Joshua D. Blank, Leigh Osofsky

Faculty Publications

Scholars are engaged in deep debate about the transformative power of recent Supreme Court cases that appear to limit the role of agencies in making rules of law. In Loper Bright Enterprises v. Raimondo and West Virginia v. EPA, the Supreme Court overruled a longstanding doctrine of judicial deference to agency rules and prescribed more boundaries around the scope of such rules. Scholars have debated to what extent these changes will usher in new forms of judicial review that will transfer power from agencies to the courts.

This Article argues that this debate misses important elements of where agency …

Gendered Words And Patent Grant Rates: A Textual Analysis, Deborah R. Gerhardt, Miriam Marcowitz-Bitton, W. Michael Schuster, Avshalom Elmalech, Omri Suissa, Moshe Mash

Faculty Publications

Text is a vehicle to convey information that reflects the writer’s linguistic style and communication patterns. By studying these attributes, we can discover latent insights about the author and their underlying message. This article uses such an approach to better understand patent applications and their inventors.

While prior research focuses on patent metadata (i.e., filing year or gendered inventor names), we employ machine learning and natural language processing to extract hidden information from the words in patent applications. Through these methods, we find that inventor gender can often be identified from textual attributes—even without knowing the inventor’s name. This ability …

Who's Afraid Of Copyright And Ai?, Deborah R. Gerhardt

Faculty Publications

Copyright and AI need not be a copyright no man’s land. Recent decisions by the Copyright Office have gotten so much media attention that many creators are unsure if they can secure copyright protection if they use AI as a creative tool. The proposed creative control paradigm can help us all tackle the challenge of determining when works created with the assistance of AI are copyrightable. Instead of relying on long-established nuanced precedent for protecting works generated with new technology, the Copyright Office asserts that any content generated with assistance from AI tools is unprotectable. This position is radically inconsistent …

Ecowas: The Little Human Rights Organization That Could, Thomas Kelley

Faculty Publications

Part I of this Article provides a detailed description of the origins of the Economic Community of West African States (ECOWAS). Part II describes its transformation from a sleepy trade bloc to a dynamic peace and security and human rights enforcement institution. Part III examines arguments about whether ECOWAS’s aggressive human rights enforcement is or is not legal under international law. Part IV summarizes developments in West Africa after ECOWAS created its robust peace and security and human rights enforcement architecture, concluding that, until the recent crisis in the Sahel States, it has been extremely effective despite the scant resources. …

Cisheterosexism In Lgbtqia+ Health Resource Guides, Vanessa Kitzie, Olivia Reed, Amirezza Kalantari

Faculty Publications

Cisheterosexism in LGBTQIA+ Health Resource Guides Vanessa Kitzie, Amirezza Kalantari, Olivia Reed University of South Carolina, School of Information Science [email protected] Limited healthcare resources lead many LGBTQIA+ people to peer networks, often accessed via search engines to find community-created health resource websites [1–3]. Academic library guides benefit privileged LGBTQIA+ identities [4], but little is known about community guides, which may reinforce cisheterosexist narratives, causing stigma and stress [5, 6]. This study addresses this gap by scraping Google results for LGBTQIA+ health resources across US states, examining how cisheterosexism shapes health topics, geography, and representation of LGBTQIA+ populations. We hypothesize that …

Workshop Outcomes Report: 2nd International Workshop On Seismic Resilience Of Arctic Infrastructure And Social Systems, Majid Ghayoomi, Daniela Morganti

Faculty Publications

The report provides an overview of the second international workshop on Seismic Resilience of Arctic Infrastructure and Social Systems. The report discusses agenda, workshop activities, interdisciplinary working groups, and results. It ends with several strategic questions and investigation plans that were developed as part of the workshop activities.

Governing By Fragments: Soviet Ruins And The Architecture Of Unaccountability In Kazakhstan, Robert A. Kopack, Magdalena E. Stawkoski

Faculty Publications

This article examines two case studies in Kazakhstan with research into how Soviet institutional legacies underwrite extractive economies that render toxic costs invisible in post-Soviet setting. Through ethnographic work in Stepnogorsk (uranium processing) and the Semipalatinsk Test Site (nuclear weapons testing), we extend Gabrielle Hecht’s residual governance framework to demonstrate how inherited bureaucratic compartmentalization now serves market rather than state interests. We introduce the concept of functional nonreform to describe how distributed actors maintain Soviet-era boundaries that prevent accountability: Agencies monitor but don’t enforce, health authorities lack jurisdiction over contaminated sites, and environmental agencies measure radiation but cannot restrict land …

Challenging Agency Deregulation, Todd S. Aagaard

Faculty Publications

The administrative state is experiencing two seismic shifts. First, in recent years, the Supreme Court has issued a series of decisions that significantly curtailed the powers of administrative agencies. Second, President Donald Trump is using administrative agencies to aggressively deregulate in his second term. The conventional wisdom is that the Supreme Court’s recent precedent will facilitate the Trump Administration’s deregulatory agenda.

This Article argues the opposite. Instead of promoting agency deregulation, recent Supreme Court precedent restraining agency authority provides a potentially powerful basis for challenging agency deregulation as administrative overreach. Time and time again, the Court has taken agencies to …