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Description Of A Program For Social Language Intervention: “If You Can Have A Conversation, You Can Have A Relationship, Lee Robinson, Bonnie Brinton, Martin Fujiki Jan 2004

Description Of A Program For Social Language Intervention: “If You Can Have A Conversation, You Can Have A Relationship, Lee Robinson, Bonnie Brinton, Martin Fujiki

Faculty Publications

Adolescents with impaired language comprehension and formulation skills often experience difficulty keeping up with the linguistic and social demands of peer interaction. This clinical exchange describes an individualized treatment program designed to increase the conversational skill of an adolescent male with language impairment. Treatment focused on increasing awareness of the listener’s needs and on balancing the exchange of conversational turns. Clinical performance, parent report, and client report were used to assess outcomes.

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Threatened Fishes Of The World: Iotichthys Phlegethontis Cope, 1874 (Cyprinidae), Joseph H. Hanks, Mark C. Belk Jan 2004

Threatened Fishes Of The World: Iotichthys Phlegethontis Cope, 1874 (Cyprinidae), Joseph H. Hanks, Mark C. Belk

Faculty Publications

Common name: least chub.

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Self-Aligned Mechanical Attachment Of Carbon Nanotubes To Silicon Dioxide Structures By Selective Silicon Dioxide Chemical-Vapor Deposition, Jed D. Whittaker, Ghaleb A. Husseini, Matthew A. Linford, Robert C. Davis, Markus Brink Dec 2003

Self-Aligned Mechanical Attachment Of Carbon Nanotubes To Silicon Dioxide Structures By Selective Silicon Dioxide Chemical-Vapor Deposition, Jed D. Whittaker, Ghaleb A. Husseini, Matthew A. Linford, Robert C. Davis, Markus Brink

Faculty Publications

A self-aligned thin-film deposition technique was developed to mechanically attach carbon nanotubes to surfaces for the fabrication of structurally robust nanotube-based nanomechanical devices. Single-walled carbon nanotubes were grown by thermal chemical-vapor deposition (CVD) across 150-nm-wide SiO2 trenches. The nanotubes were mechanically attached to the trench tops by selective silicon tetraacetate-based SiO2 CVD. No film was deposited on the nanotubes where they were suspended across the trenches.

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Agouti Expression In Human Adipose Tissue: Functional Consequences And Increased Expression In Type 2 Diabetes, Steven R. Smith, Barbara Gawronska-Kozak, Lenka Janderová, Taylor Nguyen, Angela Murrel, Jacqueline M. Stephens, Randall L. Mynatt Dec 2003

Agouti Expression In Human Adipose Tissue: Functional Consequences And Increased Expression In Type 2 Diabetes, Steven R. Smith, Barbara Gawronska-Kozak, Lenka Janderová, Taylor Nguyen, Angela Murrel, Jacqueline M. Stephens, Randall L. Mynatt

Faculty Publications

It is well recognized that the agouti/melanocortin system is an important regulator of body weight homeostasis. Given that agouti is expressed in human adipose tissue and that the ectopic expression of agouti in adipose tissue results in moderately obese mice, the link between agouti expression in human adipose tissue and obesity/type 2 diabetes was investigated. Although there was no apparent relationship between agouti mRNA levels and BMI, agouti mRNA levels were significantly elevated in subjects with type 2 diabetes. The regulation of agouti in cultured human adipocytes revealed that insulin did not regulate agouti mRNA, whereas dexamethasone treatment potently increased …

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Rubisco Activase Is Required For Optimal Photosynthesis In The Green Alga Chlamydomonas Reinhardtii In A Low-Co2 Atmosphere, Steve V. Pollock, Sergio L. Colombo, Davey L. Prout, Ashley C. Godfrey, James V. Moroney Dec 2003

Rubisco Activase Is Required For Optimal Photosynthesis In The Green Alga Chlamydomonas Reinhardtii In A Low-Co2 Atmosphere, Steve V. Pollock, Sergio L. Colombo, Davey L. Prout, Ashley C. Godfrey, James V. Moroney

Faculty Publications

This report describes a Chlamydomonas reinhardtii mutant that lacks Rubisco activase (Rca). Using the BleR (bleomycin resistance) gene as a positive selectable marker for nuclear transformation, an insertional mutagenesis screen was performed to select for cells that required a high-CO2 atmosphere for optimal growth. The DNA flanking the Ble R insert of one of the high-CO2-requiring strains was cloned using thermal asymmetric interlaced-polymerase chain reaction and inverse polymerase chain reaction and sequenced. The flanking sequence matched the C. reinhardtii Rca cDNA sequence previously deposited in the National Center for Biotechnology Information database. The loss of a functional Rca in the …

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Molecular And Culture-Based Analyses Of Aerobic Carbon Monoxide Oxidizer Diversity, Gary M. King Dec 2003

Molecular And Culture-Based Analyses Of Aerobic Carbon Monoxide Oxidizer Diversity, Gary M. King

Faculty Publications

Isolates belonging to six genera not previously known to oxidize CO were obtained from enrichments with aquatic and terrestrial plants. DNA from these and other isolates was used in PCR assays of the gene for the large subunit of carbon monoxide dehydrogenase (coxL). CoxL and putative coxL fragments were amplified from known CO oxidizers (e.g., Oligotropha carboxidovorans and Bradyrhizobium japonicum), from novel CO-oxidizing isolates (e.g., Aminobacter sp. strain COX, Burkholderia sp. strain LUP, Mesorhizobium sp. strain NMB1, Stappia strains M4 and M8, Stenotrophomonas sp. strain LUP, and Xanthobacter sp. strain COX), and from several well-known isolates for which the capacity …

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Uptake Of Carbon Monoxide And Hydrogen At Environmentally Relevant Concentrations By Mycobacteria, Gary M. King Dec 2003

Uptake Of Carbon Monoxide And Hydrogen At Environmentally Relevant Concentrations By Mycobacteria, Gary M. King

Faculty Publications

Liquid culture assays revealed a previously unreported capacity for Mycobacterium bovis BCG, M. gordonae, and M. marinum to oxidize CO and for M. smegmatis to consume molecular hydrogen. M. bovis BCG, M. gordonae, M. smegmatis, and M. tuberculosis H37Ra oxidized CO at environmentally relevant concentrations (<50 >ppm); H2 oxidation by M. gordonae and M. smegmatis also occurred at environmentally relevant concentrations (< 10 ppm). CO was not consumed by M. avium or M. microti, although the latter appeared to possess CO dehydrogenase (CODH) genes based on PCR results with primers designed for the CODH large subunit, coxL. M. smegmatis and M. gordonae oxidized CO under suboxic (10 and 1% atmospheric oxygen) and anoxic conditions in the presence of nitrate; no oxidation occurred under anoxic conditions without nitrate. Similar results were obtained for H2 oxidation by M. smegmatis. Phylogenetic analyses of coxL PCR products indicated that mycobacterial sequences form a subclade distinct from that of other bacterial coxL, with limited differentiation among fast- and slow-growing strains.

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A New Approach To Modeling Vertical Stiffness In Heel-Toe Distance Runners, Iain Hunter Dec 2003

A New Approach To Modeling Vertical Stiffness In Heel-Toe Distance Runners, Iain Hunter

Faculty Publications

Various models have been used to describe distance running technique. Among these, the mass-spring model is fairly simple to use and apply, but when employed as a model, does not predict vertical force accurately especially when a heel strike is exhibited. The purpose of this article is to demonstrate how the mass-spring model can be modified to provide a simple, yet accurate prediction of ground reaction forces in distance running. Sixteen subjects ran on a force instrumented treadmill. Vertical forces during running at a self-selected pace were collected at 500 Hz. Vertical stiffness was calculated using the conventional mass-spring model …

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Rates Of Species Loss From Amazonian Forest Fragments, Gonçalo Ferraz, Gareth J. Russell, Philip C. Stouffer, Richard O. Bierregaard, Stuart L. Pimm, Thomas E. Lovejoy Nov 2003

Rates Of Species Loss From Amazonian Forest Fragments, Gonçalo Ferraz, Gareth J. Russell, Philip C. Stouffer, Richard O. Bierregaard, Stuart L. Pimm, Thomas E. Lovejoy

Faculty Publications

In the face of worldwide habitat fragmentation, managers need to devise a time frame for action. We ask how fast do understory bird species disappear from experimentally isolated plots in the Biological Dynamics of Forest Fragments Project, central Amazon, Brazil. Our data consist of mist-net records obtained over a period of 13 years in 11 sites of 1, 10, and 100 hectares. The numbers of captures per species per unit time, analyzed under different simplifying assumptions, reveal a set of species-loss curves. From those declining numbers, we derive a scaling rule for the time it takes to lose half the …

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Understanding Why Adult Participants At The World Senior Games Choose A Healthy Diet, Ray M. Merrill, Eric C. Shields Nov 2003

Understanding Why Adult Participants At The World Senior Games Choose A Healthy Diet, Ray M. Merrill, Eric C. Shields

Faculty Publications

Identifying those seniors most likely to adopt a healthy diet, the relative importance they place on certain perceived benefits associated with a healthy diet, and whether these perceived benefits are associated with selected demographic, lifestyle, and health history variables is important for directing effective dietary health promotion programs. Methods: Analyses are based on a cross-sectional convenience sample of 670 seniors aged 50 years and older at the 2002 World Senior Games in St. George, Utah. Data are assessed using frequencies, bivariate analysis, analysis of variance, and multiple logistic regression analysis. Results Fruit and vegetable consumption was significantly higher in individuals …

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High Throughput Virus-Induced Gene Silencing Implicates Heat Shock Protein 90 In Plant Disease Resistance, Rui Lu, Isabelle Malcuit, Peter Moffett, Maria T. Ruiz, Jack Peart, Ai Jiuan Wu, John P. Rathjen, Abdelhafid Bendahmane, Louise Day, David C. Baulcombe Nov 2003

High Throughput Virus-Induced Gene Silencing Implicates Heat Shock Protein 90 In Plant Disease Resistance, Rui Lu, Isabelle Malcuit, Peter Moffett, Maria T. Ruiz, Jack Peart, Ai Jiuan Wu, John P. Rathjen, Abdelhafid Bendahmane, Louise Day, David C. Baulcombe

Faculty Publications

Virus-induced gene silencing was used to assess the function of random Nicotiana benthamiana cDNAs in disease resistance. Out of 4992 cDNAs tested from a normalized library, there were 79 that suppressed a hypersensitive response (HR) associated with Pto-mediated resistance against Pseudomonas syringae. However, only six of these clones blocked the Pto-mediated suppression of P. syringae growth. The three clones giving the strongest loss of Pto resistance had inserts corresponding to HSP90 and also caused loss of Rx-mediated resistance against potato virus X and N-mediated tobacco mosaic virus resistance. The role of HSP90 as a cofactor of disease resistance is associated …

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Methods For Estimating Long-Distance Dispersal, Ran Nathan, Gad Perry, James T. Cronin, Allan E. Strand, Michael L. Cain Nov 2003

Methods For Estimating Long-Distance Dispersal, Ran Nathan, Gad Perry, James T. Cronin, Allan E. Strand, Michael L. Cain

Faculty Publications

Long-distance dispersal (LDD) includes events in which propagules arrive, but do not necessarily establish, at a site far removed from their origin. Although important in a variety of ecological contexts, the system-specific nature of LDD makes "far removed" difficult to quantify, partly, but not exclusively, because of inherent uncertainty typically involved with the highly stochastic LDD processes. We critically review the main methods employed in studies of dispersal, in order to facilitate the evaluation of their pertinence to specific aspects of LDD research. Using a novel classification framework, we identify six main methodological groups: biogeographical; Eulerian and Lagrangian movement/redistributional; short-term …

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Identification Of Three Genomic Haplotypes 5′ To The Human Cd1d Gene And Their Distribution In Four Ethnic Groups, Q. Y. Chen, N. Jackson, A. Vargas, S. Chalew, J. Rao, M. Batzer, M. S. Lan, Y. H. Chang, M. Mokhashi, D. Liu Nov 2003

Identification Of Three Genomic Haplotypes 5′ To The Human Cd1d Gene And Their Distribution In Four Ethnic Groups, Q. Y. Chen, N. Jackson, A. Vargas, S. Chalew, J. Rao, M. Batzer, M. S. Lan, Y. H. Chang, M. Mokhashi, D. Liu

Faculty Publications

CD1d presents lipid antigen to a conserved population of natural killer (NK) T cells, which participate in host immune defense, tumor cell rejection and suppression of autoimmunity. The levels of human CD1d expression vary significantly between individuals. To understand such variation, we sequenced the region up to 1.7 kb 5′ upstream of the translation start site and partially through exon 2 in 44 white Americans. We also studied two tagged single nucleotide polymorphisms (SNP) in 112 white Americans, 60 African-Americans, 88 Europeans, and 84 Chinese people from the region. Six SNP present in the region (-836C→T, -773C→T, -764C→G, -713A→T, -365A→G …

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An Analysis Of Single Clutch Paternity In The Burrower Bug Sehirus Cinctus Using Microsatellites, Jeremy M. Brown, Aneil F. Agrawal, Edmund D. Brodie Nov 2003

An Analysis Of Single Clutch Paternity In The Burrower Bug Sehirus Cinctus Using Microsatellites, Jeremy M. Brown, Aneil F. Agrawal, Edmund D. Brodie

Faculty Publications

Recent studies of the burrower bug, Sehirus cinctus, have examined the genetic basis of parental care. An understanding of the burrower bug mating system, and the subsequent pattern of offspring relatedness that this system generates, is critical to further interpret genetic data. To this end, we developed three consistently amplifiable highly polymorphic microsatellite loci and used them to determine genotypic patterns at the level of both the population and the single clutch. We found that all clutches were sired by single males. Further, we find no evidence for inbreeding. We hypothesize that single paternity within a clutch may play an …

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Pelvic Sexual Dimorphism In A Metatherian, Didelphis Virginiana: Implications For Eutherians, Robert G. Tague Nov 2003

Pelvic Sexual Dimorphism In A Metatherian, Didelphis Virginiana: Implications For Eutherians, Robert G. Tague

Faculty Publications

Eutherians give birth to relatively large infants. Females have larger pelves than males, though males typically have larger nonpelvic bones. Pelvic dimorphism is an adaptation for parturition. Metatherian females, who give birth to markedly small infants, should not show pelvic adaptations for parturition and should have smaller pelves than males. Adult females and males of the Virginia opossum, Didelphis virginiana, are compared. Males are significantly larger than females in absolute size for 14 of 16 pelvic and 8 nonpelvic measures. Sexes did not differ significantly for lower iliac length and posterior space of midplane. However, relative lengths for females are …

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Similar Gene Structure Of Two Sox9a Genes And Their Expression Patterns During Gonadal Differentiation In A Teleost Fish, Rice Field Eel (Monopterus Albus), Rongjia Zhou, Li Liu, Yiqing Guo, Hongshi Yu, Hanhua Cheng, Xiao Huang, Terrence R. Tiersch, Philippe Berta Nov 2003

Similar Gene Structure Of Two Sox9a Genes And Their Expression Patterns During Gonadal Differentiation In A Teleost Fish, Rice Field Eel (Monopterus Albus), Rongjia Zhou, Li Liu, Yiqing Guo, Hongshi Yu, Hanhua Cheng, Xiao Huang, Terrence R. Tiersch, Philippe Berta

Faculty Publications

The Sox9 gene encodes a transcription factor that is critical for testis determination and chondrogenesis in vertebrates. Mutations in human SOX9 cause campomelic dysplasia, a dominant skeletal dysmorphology syndrome often associated with male to female sex reversal. Here we show that the Sox9a gene was duplicated during evolution of the rice field eel, Monopterus albus, a freshwater fish which undergoes natural sex reversal from female to male during its life, and has a haploid genome size (0.6-0.8 pg) that is among the smallest of the vertebrates. The duplicated copies of the gene (named Sox9a1 and Sox9a2) fit within the Sox9 …

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The Maintenance Of Conservative Physical Laws Within Data Assimilation Systems, G.A. Jacobs, H.E. Ngodock Nov 2003

The Maintenance Of Conservative Physical Laws Within Data Assimilation Systems, G.A. Jacobs, H.E. Ngodock

Faculty Publications

In many data assimilation applications, adding an error to represent forcing to certain dynamical equations may be physically unrealistic. Four-dimensional variational methods assume either an error in the dynamical equations of motion (weak constraint) or no error (strong constraint). The weak-constraint methodology proposes the errors to represent uncertainties in either forcing of the dynamical equations or parameterizations of dynamics. Dynamical equations that represent conservation of quantities (mass, entropy, momentum, etc.) may be cast in an analytical or control volume flux form containing minimal errors. The largest errors arise in determining the fluxes through control volume surfaces. Application of forcing errors …

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A Study Of Enso Prediction Using A Hybrid Coupled Model And The Adjoint Method For Data Assimilation, Eli Galanti, Eli Tziperman, Matthew Harrison, Anthony Rosati, Ziv Sirkes Nov 2003

A Study Of Enso Prediction Using A Hybrid Coupled Model And The Adjoint Method For Data Assimilation, Eli Galanti, Eli Tziperman, Matthew Harrison, Anthony Rosati, Ziv Sirkes

Faculty Publications

An experimental ENSO prediction system is presented, based on an ocean general circulation model (GCM) coupled to a statistical atmosphere and the adjoint method of 4D variational data assimilation. The adjoint method is used to initialize the coupled model, and predictions are performed for the period 1980-99. The coupled model is also initialized using two simpler assimilation techniques: forcing the ocean model with observed sea surface temperature and surface fluxes, and a 3D variational data assimilation (3DVAR) method, similar to that used by the National Centers for Environmental Prediction (NCEP) for operational ENSO prediction. The prediction skill of the coupled …

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Alu Elements And Hominid Phylogenetics, Abdel Halim Salem, David A. Ray, Jinchuan Xing, Pauline A. Callinan, Jeremy S. Myers, Dale J. Hedges, Randall K. Garber, David J. Witherspoon, Lynn B. Jorde, Mark A. Batzer Oct 2003

Alu Elements And Hominid Phylogenetics, Abdel Halim Salem, David A. Ray, Jinchuan Xing, Pauline A. Callinan, Jeremy S. Myers, Dale J. Hedges, Randall K. Garber, David J. Witherspoon, Lynn B. Jorde, Mark A. Batzer

Faculty Publications

Alu elements have inserted in primate genomes throughout the evolution of the order. One particular Alu lineage (Ye) began amplifying relatively early in hominid evolution and continued propagating at a low level as many of its members are found in a variety of hominid genomes. This study represents the first conclusive application of short interspersed elements, which are considered nearly homoplasy-free, to elucidate the phylogeny of hominids. Phylogenetic analysis of Alu Ye5 elements and elements from several other subfamilies reveals high levels of support for monophyly of Hominidae, tribe Hominini and subtribe Hominina. Here we present the strongest evidence reported …

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Pyridoxamine Traps Intermediates In Lipid Peroxidation Reactions In Vivo: Evidence On The Role Of Lipids In Chemical Modification Of Protein And Development Of Diabetic Complications, Thomas O. Metz, Nathan L. Alderson, Mark E. Chachich, Suzanne R. Thorpe, John W. Baynes Oct 2003

Pyridoxamine Traps Intermediates In Lipid Peroxidation Reactions In Vivo: Evidence On The Role Of Lipids In Chemical Modification Of Protein And Development Of Diabetic Complications, Thomas O. Metz, Nathan L. Alderson, Mark E. Chachich, Suzanne R. Thorpe, John W. Baynes

Faculty Publications

Maillard or browning reactions between reducing sugars and protein lead to formation of advanced glycation end products (AGEs) and are thought to contribute to the pathogenesis of diabetic complications. AGE inhibitors such as aminoguanidine and pyridoxamine (PM) inhibit both the formation of AGEs and development of complications in animal models of diabetes. PM also inhibits the chemical modification of protein by advanced lipoxidation end products (ALEs) during lipid peroxidation reactions in vitro. We show here that several PM adducts, formed in incubations of PM with linoleate and arachidonate in vitro, are also excreted in the urine of PM-treated animals. The …

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Comprehensive Analysis Of Alu-Associated Diversity On The Human Sex Chromosomes, Pauline A. Callinan, Dale J. Hedges, Abdel Halim Salem, Jinchuan Xing, Jerilyn A. Walker, Randall K. Garber, W. Scott Watkins, Michael J. Bamshad, Lynn B. Jorde, Mark A. Batzer Oct 2003

Comprehensive Analysis Of Alu-Associated Diversity On The Human Sex Chromosomes, Pauline A. Callinan, Dale J. Hedges, Abdel Halim Salem, Jinchuan Xing, Jerilyn A. Walker, Randall K. Garber, W. Scott Watkins, Michael J. Bamshad, Lynn B. Jorde, Mark A. Batzer

Faculty Publications

A comprehensive analysis of the human sex chromosomes was undertaken to assess Alu-associated human genomic diversity and to identify novel Alu insertion polymorphisms for the study of human evolution. Three hundred forty-five recently integrated Alu elements from eight different Alu subfamilies were identified on the X and Y chromosomes, 225 of which were selected and analyzed by polymerase chain reaction (PCR). From a total of 225 elements analyzed, 16 were found to be polymorphic on the X chromosome and one on the Y chromosome. In line with previous research using other classes of genetic markers, our results indicate reduced Alu-associated …

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Stem Cell Research?: Yes--Out Of Love For The Neighbor, Alan G. Padgett Oct 2003

Stem Cell Research?: Yes--Out Of Love For The Neighbor, Alan G. Padgett

Faculty Publications

No abstract provided.

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Evolution, Theology, And Method - Part 2: Scientific Method And Evolution, Fernando L. Canale Oct 2003

Evolution, Theology, And Method - Part 2: Scientific Method And Evolution, Fernando L. Canale

Faculty Publications

No abstract provided.

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Nitric Oxide Mediates Seasonal Muscle Potentiation In Clam Gills, Louis F. Gainey Jr., Michael J. Greenberg Oct 2003

Nitric Oxide Mediates Seasonal Muscle Potentiation In Clam Gills, Louis F. Gainey Jr., Michael J. Greenberg

Faculty Publications

The physiology and timing of gill muscle potentiation were explored in the clam Mercenaria mercenaria. When isolated demibranchs were exposed twice (with an intervening wash) to the same concentration of 5-hydroxytryptamine, the second contraction was larger than the first. This potentiation was seasonal: it was present from November through June, and absent from July through October. Potentiation was not affected by the geographic origin of the clams, nor by their acclimation temperature. Potentiation was inhibited by the nitric oxide synthase (NOS) inhibitor L-NAME and mimicked by the nitric oxide (NO) donor DEANO. During the season of potentiation, immunoreactive NOS appeared …

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Molecular Characterization Of Brucella Abortus Chromosome Ii Recombination, Georgios Tsoktouridis, Christian A. Merz, Simon P. Manning, Renée Giovagnoli-Kurtz, Leanne E. Williams, Cesar V. Mujer, Sue Hagius, Philip Elzer, Rajendra J. Redkar, Guy Patra, Vito G. Delvecchio Oct 2003

Molecular Characterization Of Brucella Abortus Chromosome Ii Recombination, Georgios Tsoktouridis, Christian A. Merz, Simon P. Manning, Renée Giovagnoli-Kurtz, Leanne E. Williams, Cesar V. Mujer, Sue Hagius, Philip Elzer, Rajendra J. Redkar, Guy Patra, Vito G. Delvecchio

Faculty Publications

Large-scale genomic rearrangements including inversions, deletions, and duplications are significant in bacterial evolution. The recently completed Brucella melitensis 16M and Brucella suis 1330 genomes have facilitated the investigation of such events in the Brucella spp. Suppressive subtractive hybridization (SSH) was employed in identifying genomic differences between B. melitensis 16M and Brucella abortus 2308. Analysis of 45 SSH clones revealed several deletions on chromosomes of B. abortus and B. melitensis that encoded proteins of various metabolic pathways. A 640-kb inversion on chromosome II of B. abortus has been reported previously (S. Michaux Charachon, G. Bourg, E. Jumas Bilak, P. Guigue Talet, …

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Thermodynamics Of The Binding Of Thermus Aquaticus Dna Polymerase To Primed-Template Dna, Kausiki Datta, Vince J. Licata Oct 2003

Thermodynamics Of The Binding Of Thermus Aquaticus Dna Polymerase To Primed-Template Dna, Kausiki Datta, Vince J. Licata

Faculty Publications

DNA binding of the Type 1 DNA polymerase from Thermus aquaticus (Taq polymerase) and its Klentaq large fragment domain have been studied as a function of temperature. Equilibrium binding assays were performed from 5 to 70°C using a fluorescence anisotropy assay and from 10 to 60°C using isothermal titration calorimetry. In contrast to the usual behavior of thermophilic proteins at low temperatures, Taq and Klentaq bind DNA with high affinity at temperatures down to 5°C. The affinity is maximal at 40-50°C. The ΔH and ΔS of binding are highly temperature dependent, and the ΔCp of binding is -0.7 to -0.8 …

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Mitochondrial Mrna Stability And Polyadenylation During Anoxia-Induced Quiescence In The Brine Shrimp Artemia Franciscana, Brian D. Eads, Steven C. Hand Oct 2003

Mitochondrial Mrna Stability And Polyadenylation During Anoxia-Induced Quiescence In The Brine Shrimp Artemia Franciscana, Brian D. Eads, Steven C. Hand

Faculty Publications

Polyadenylation of messenger RNA is known to be an important mechanism for regulating mRNA stability in a variety of systems, including bacteria, chloroplasts and plant mitochondria. By comparison, little is known about the role played by polyadenylation in animal mitochondrial gene expression. We have used embryos of the brine shrimp Artemia franciscana to test hypotheses regarding message stability and polyadenylation under conditions simulating anoxia-induced quiescence. In response to anoxia, these embryos undergo a profound and acute metabolic downregulation, characterized by a steep drop in intracellular pH (pHi) and ATP levels. Using dot blots of total mitochondrial RNA, we show that …

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The Effect Of Density-Dependent Catastrophes On Population Persistence Time, Chris Wilcox, Bret Elderd Oct 2003

The Effect Of Density-Dependent Catastrophes On Population Persistence Time, Chris Wilcox, Bret Elderd

Faculty Publications

1. There has been increasing recognition that catastrophes are an important factor in modelling threatened populations. However, density dependence has generally been omitted from models of threatened populations on the assumption that this omission yields conservative predictions. We explore the significance of including density-dependent catastrophes in models of threatened populations. 2. Using an analytical model, we show that density-dependent catastrophes have a significant effect on population persistence, decreasing mean persistence time at large population sizes and causing a relative increase at intermediate sizes. 3. We illustrate our results with empirical data from a disease outbreak in crabeater seals Lobodon carcinophagus …

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Human Rights And Genetic Discrimination: Protecting Genomics' Promise For Public Health, Anita Silvers, Michael Ashley Stein Oct 2003

Human Rights And Genetic Discrimination: Protecting Genomics' Promise For Public Health, Anita Silvers, Michael Ashley Stein

Faculty Publications

No abstract provided.

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Trust Negotiation For Authentication And Authorization In Healthcare Information Systems, Charles D. Knutson, Kent E. Seamons, Tore L. Sundelin, David K. Vawdrey Sep 2003

Trust Negotiation For Authentication And Authorization In Healthcare Information Systems, Charles D. Knutson, Kent E. Seamons, Tore L. Sundelin, David K. Vawdrey

Faculty Publications

The expanding availability of health information in an electronic format is strategic for industry-wide efforts to improve the quality and reduce the cnst of health care. The implementation of electronic medical record systems has been hindered by inadequate security provisions. This paper describes the use of frust negotiation as a framework for providing authentication and access control services in healthcare information systems. nust negotiation enables two parties with no pre-existing relationship to establish the trust necessary to perform sensitive transactions via the mutual disclosure of attributes contained within digital credentials. An extension of this system, surrogate irusf negoikiion is introduced …

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