Digital Commons Network^™

Psychologism And American Instructional Technology, David Wiley, Bekir Gur

Faculty Publications

Note: This is not the final draft of the article. The centrality of psychology in the field of instructional technology has never been comprehensively questioned; most instructional technologists have assumed that (behaviorist, cognitivist, constructivist, or another) psychology is the natural foundation for education and thus for instructional technology. The driving question of this article is: What are the problems of psychologism as found in the theories and practices of instructional technology? We present a brief genealogy of American instructional technology in relation to the influence of psychology; review critical psychology and discuss some problems of psychologism focusing on positivism, metaphysics, …

Patterns Of User Activity In The Different Features Of The Blackboard Cms Across All Courses For An Academic Year At Brigham Young University, Michael E. Griffiths, Charles R. Graham

Faculty Publications

In the past decade, course management systems (CMS) have become an integral part of most institutions of higher education. While there has been a significant amount of research looking at CMS usage at the course level, there has been less research looking at the institution-wide CMS usage from a CMS activity database perspective. This article shares findings from a study which analyzes over 36 million student and instructor clicks within the Blackboard CMS across the entire campus of Brigham Young University (BYU) during one full academic year. This research reports overall levels of user activity across campus, patterns of user …

Tobacco Mosaic Virus Templated Synthesis Of One Dimensional Inorganic-Polymer Hybrid Fibres, Jianhua Rong, Fiona Oberbeck, Xinnan Wang, Xiaodong Li, Jerry Oxsher, Zhongwei Niu, Qian Wang

Faculty Publications

Inorganic–polymer hybrid nanofibres were prepared by using a rod-like tobacco mosaic virus (TMV) as a template. With tetraethylorthosilicate (TEOS) as a precursor, long silica-coated TMVfibres were formed via a head-to-tail assembly, which showed a substantial increase of the elastic modulus. Furthermore, homogenous titania–TMV hybrid fibres could be prepared using polyaniline-coated TMV fibres as a template, which were used to form a composite film that was able to sense liquefied petroleum gases.

Compensating For Wetland Losses Under The Clean Water Act (Redux): Evaluating The Federal Compensatory Mitigation Regulation, Royal C. Gardner, Joy Zedler, Ann Redmond, R. Eugene Turner, Carol A. Johnston, Victoria R. Alverez, Charles A. Simenstad, Karen L. Prestegaard, William J. Mitsch

Faculty Publications

No abstract provided.

The Structure Of The Cornified Claw Sheath In The Domesticated Cat (Felis Catus): Implications For The Claw-Shedding Mechanism And The Evolution Of Cornified Digital End Organs, Dominique G. Homberger, Kyungmin Ham, Tolulope Ogunbakin, Jonathan A. Bonin, Brooke A. Hopkins, Michelle L. Osborn, Imtiaz Hossain, Heath A. Barnett, Kenneth L. Matthews, Leslie G. Butler, Hermann H. Bragulla

Faculty Publications

The morphology of cornified structures is notoriously difficult to analyse because of the extreme range of hardness of their component tissues. Hence, a correlative approach using light microscopy, scanning electron microscopy, three-dimensional reconstructions based on x-ray computed tomography data, and graphic modeling was applied to study the morphology of the cornified claw sheath of the domesticated cat as a model for cornified digital end organs. The highly complex architecture of the cornified claw sheath is generated by the living epidermis that is supported by the dermis and distal phalanx. The latter is characterized by an ossified unguicular hood, which overhangs …

Genome Degradation In Brucella Ovis Corresponds With Narrowing Of Its Host Range And Tissue Tropism, Renee M. Tsolis, Rekha Seshadri, Renato L. Santos, Felix J. Sangari, Juan M. García Lobo, Maarten F. De Jong, Qinghu Ren, Garry Myers, Lauren M. Brinkac, William C. Nelson, Robert T. Deboy, Samuel Angiuoli, Hoda Khouri, George Dimitrov, Jeffrey R. Robinson, Stephanie Mulligan, Richard L. Walker, Philip E. Elzer, Karl A. Hassan, Ian T. Paulsen

Faculty Publications

Brucella ovis is a veterinary pathogen associated with epididymitis in sheep. Despite its genetic similarity to the zoonotic pathogens B. abortus, B. melitensis and B. suis, B. ovis does not cause zoonotic disease. Genomic analysis of the type strain ATCC25840 revealed a high percentage of pseudogenes and increased numbers of transposable elements compared to the zoonotic Brucella species, suggesting that genome degradation has occurred concomitant with narrowing of the host range of B. ovis. The absence of genomic island 2, encoding functions required for lipopolysaccharide biosynthesis, as well as inactivation of genes encoding urease, nutrient uptake and utilization, and outer …

The Structure Of The Cornified Claw Sheath In The Domesticated Cat (Felis Catus): Implications For The Claw-Shedding Mechanism And The Evolution Of Cornified Digital End Organs, Dominique G. Homberger, Kyungmin Ham, Tolulope Ogunbakin, Jonathan A. Bonin, Brooke A. Hopkins, Michelle L. Osborn, Imtiaz Hossain, Heath A. Barnett, Kenneth L. Matthews, Leslie G. Butler, Hermann H. Bragulla

Faculty Publications

The morphology of cornified structures is notoriously difficult to analyse because of the extreme range of hardness of their component tissues. Hence, a correlative approach using light microscopy, scanning electron microscopy, three-dimensional reconstructions based on x-ray computed tomography data, and graphic modeling was applied to study the morphology of the cornified claw sheath of the domesticated cat as a model for cornified digital end organs. The highly complex architecture of the cornified claw sheath is generated by the living epidermis that is supported by the dermis and distal phalanx. The latter is characterized by an ossified unguicular hood, which overhangs …

Contemporary Proton Therapy Systems Adequately Protect Patients From Exposure To Stray Radiation, Wayne D. Newhauser, Jonas D. Fontenot, Phillip J. Taddei, Dragan Mirkovic, Annelise Giebeler, Rui Zhang, Anita Mahajan, David Kornguth, Marilyn Stovall, Pablo Yepes, Shiao Woo, Radhe Mohan

Faculty Publications

Proton beam therapy has provided safe and effective treatments for a variety of adult cancers. In recent years, there has been increasing interest in utilizing proton therapy for pediatric cancers because it allows better sparing of healthy tissues. Minimizing exposures of normal tissues is especially important in children because they are highly susceptible to consequential late effects, including the development of a radiogenic second cancer, which may occur years or even decades after treatment of the first cancer. While the dosimetric advantage of therapeutic proton beams is well understood, relatively little attention has been paid to the whole-body exposure to …

Effective Dose From Stray Radiation For A Patient Receiving Proton Therapy For Liver Cancer, Phillip J. Taddei, Sunil Krishnan, Dragan Mirkovic, Pablo Yepes, Wayne D. Newhauser

Faculty Publications

Because of its advantageous depth-dose relationship, proton radiotherapy is an emerging treatment modality for patients with liver cancer. Although the proton dose distribution conforms to the target, healthy tissues throughout the body receive low doses of stray radiation, particularly neutrons that originate in the treatment unit or in the patient. The aim of this study was to calculate the effective dose from stray radiation and estimate the corresponding risk of second cancer fatality for a patient receiving proton beam therapy for liver cancer. Effective dose from stray radiation was calculated using detailed Monte Carlo simulations of a double-scattering proton therapy …

Can We Apply The Mendelian Randomization Methodology Without Considering Epigenetic Effects?, Ikechkwu U. Ogbuanu, Hongmei Zhang, Wilfried J. Karmaus

Faculty Publications

Introduction: Instrumental variable (IV) methods have been used in econometrics for several decades now, but have only recently been introduced into the epidemiologic research frameworks. Similarly, Mendelian randomization studies, which use the IV methodology for analysis and inference in epidemiology, were introduced into the epidemiologist's toolbox only in the last decade.

Analysis: Mendelian randomization studies using instrumental variables (IVs) have the potential to avoid some of the limitations of observational epidemiology (confounding, reverse causality, regression dilution bias) for making causal inferences. Certain limitations of randomized controlled trials, such as problems with generalizability, feasibility and ethics for some exposures, and high …

Structure And Functions Of Keratin Proteins In Simple, Stratified, Keratinized And Cornified Epithelia, Hermann H. Bragulla, Dominique G. Homberger

Faculty Publications

Historically, the term 'keratin' stood for all of the proteins extracted from skin modifications, such as horns, claws and hooves. Subsequently, it was realized that this keratin is actually a mixture of keratins, keratin filament-associated proteins and other proteins, such as enzymes. Keratins were then defined as certain filament-forming proteins with specific physicochemical properties and extracted from the cornified layer of the epidermis, whereas those filament-forming proteins that were extracted from the living layers of the epidermis were grouped as 'prekeratins' or 'cytokeratins'. Currently, the term 'keratin' covers all intermediate filament-forming proteins with specific physicochemical properties and produced in any …

Factors Related To Objectively Measured Physical Activity In Preschool Children, Karin A. Pfeiffer, Marsha Dowda, Kerry L. Mciver, Russell R. Pate

Faculty Publications

This study examined correlates of objectively measured physical activity (PA) in a diverse sample of preschool children (age 3-5 years; n=331). Accelerometer min∙hr^-1 of moderate-to-vigorous physical activity (MVPA) and nonsedentary activity (NSA) were the outcome measures. Correlations among potential correlates and PA ranged from r=-0.12-0.26. Correlates in the final MVPA model were age, race, sex, BMI Z score, and parent perception of athletic competence, explaining 37% of the variance. The NSA model included the latter two variables, explaining 35% of the variance. Demographic factors were correlates of PA; parent perceptions of children's competence may be important regarding …

Repair-Mediated Duplication By Capture Of Proximal Chromosomal Dna Has Shaped Vertebrate Genome Evolution, John K. Pace, Shurjo K. Sen, Mark A. Batzer, Cédric Feschotte

Faculty Publications

DNA double-strand breaks (DSBs) are a common form of cellular damage that can lead to cell death if not repaired promptly. Experimental systems have shown that DSB repair in eukaryotic cells is often imperfect and may result in the insertion of extra chromosomal DNA or the duplication of existing DNA at the breakpoint. These events are thought to be a source of genomic instability and human diseases, but it is unclear whether they have contributed significantly to genome evolution. Here we developed an innovative computational pipeline that takes advantage of the repetitive structure of genomes to detect repair-mediated duplication events …

Cobaltacarborane-Phthalocyanine Conjugates: Syntheses And Photophysical Properties, Hairong Li, Frank R. Fronczek, M. Graça H. Vicente

Faculty Publications

Syntheses of two new cobaltacarborane-phthalocyanine conjugates, one anionic (Pc 6) and one zwitterionic (Pc 7), were accomplished via cyclotetramerization of the corresponding cobaltacarborane-substituted phthalonitriles (4 or 5) with excess phthalonitrile in quinoline. X-ray structures of two phthalonitrile precursors (2 and 3) were obtained and are discussed, and the absorption and emission properties of the two cobaltacarborane-phthalocyanine conjugates in several solvents were investigated. The anionic conjugate 6 exists mainly as a monomer in polar organic solvents and has fluorescence quantum yields in the region 0.2-0.3. The zwitterionic conjugate 7 aggregates in solution and displays lower quantum yields ∼0.1 in organic solvents. …

Changes In Composition Of Culturable Bacteria Community In The Gut Of The Formosan Subterranean Termite Depending On Rearing Conditions Of The Host, C. Husseneder, J. M. Berestecky, J. K. Grace

Faculty Publications

The hindgut of feeding termites that feed on wood and litter contains a diverse population of bacteria and protists that contribute to the carbon, nitrogen, and energy requirements of the termite. For understanding the ecological balance in the termite gut, detailed knowledge about the composition of the microbial gut flora is imperative, i.e., the numbers and relative proportions of the microbial taxa and the variability in the microbial composition among different termite colonies and living conditions of termites should be described. Therefore, we isolated and enumerated eight bacterial morphotypes from the gut of the Formosan subterranean termite, Coptotermes]]formosanus Shiraki. Five …

Interpreting Facial Expressions: The Influence Of Social Anxiety, Emotional Valence, And Race, Lora Rose Hunter, Julia D. Buckner, Norman B. Schmidt

Faculty Publications

Social anxiety is posited to be linked to interpersonal skills deficits, including accurate interpretation of emotional social cues, such as facial expressions. However, empirical support for an interpersonal skills deficit model of social anxiety is lacking. Studies of information processes indicate that socially anxious individuals may be more accurate at identifying threatening facial expressions in particular. In the present study, undergraduates who self-identified as Caucasian (N = 158) completed a task assessing facial expression accuracy. Relevant parameters such as emotional valence as well as race of the target were assessed. As predicted, socially anxious individuals were overall more accurate at …

My Two Boots ... A Walk Through The Wetlands. An Annual Outing For 700 Middle School Students, Julie Cwikla, Mark Lasalle, Sybil Wilner

Faculty Publications

No abstract provided.

The Northern Eurasia Earth Science Partnership: An Example Of Science Applied To Societal Needs, Pavel Ya. Groisman, Elizabeth A. Clark, Vladimir M. Kattsov, Dennis P. Lettenmaier, Irina N. Sokolik, Vladimir B. Aizen, Oliver Cartus, Jiquan Chen, Susan Conard, John Katzenberger, Olga Krankina, Jaakko Kukkonen, Toshinobu Machida, Shamil Maksyutov, Dennis Ojima, Jiaguo Qi, Vladimir E. Romanovsky, Maurizio Santoro, Christiane C. Schmullius, Alexander I. Shiklomanov, Kou Shimoyama, Herman H. Shugart, Jacquelyn K. Shuman, Mikhail A. Sofiev

Faculty Publications

Northern Eurasia, the largest landmass in the northern extratropics, accounts for ~20% of the global land area. However, little is known about how the biogeochemical cycles, energy and water cycles, and human activities specific to this carbon-rich, cold region interact with global climate. A major concern is that changes in the distribution of land-based life, as well as its interactions with the environment, may lead to a self-reinforcing cycle of accelerated regional and global warming. With this as its motivation, the Northern Eurasian Earth Science Partnership Initiative (NEESPI) was formed in 2004 to better understand and quantify feedbacks between northern …

Where Is Thy Glory? Moses 1, The Nature Of Truth And The Plan Of Salvation, Dan Belnap, Daniel L. Belnap

Faculty Publications

While the first chapter of the book of Moses is often understood as introductory to the rest of the book, the chapter itself is an inclusive text centering on Moses’s transformation through three separate encounters with supernatural beings. In each encounter he is taught something of the meaning of truth and experiences the power that the comprehension of truth brings. His example is particularly instructive in light of the doctrine that “truth is knowledge of things as they are, and as they were, and as they are to come” (D&C 93:24).

The first section of Moses 1 contains Moses’s encounter …

Transcriptomic Analysis Of The Entomopathogenic Nematode Heterorhabditis Bacteriophora Tto1, Byron J. Adams, Xiaodong Bai, Todd A. Ciche, Sandra Clifton, Randy Gaugler, Parwinder S. Grewal, Saskia A. Hogenhout, John Spieth, Paul W. Sternberg, Richard K. Wilson

Faculty Publications

Background: The entomopathogenic nematode Heterorhabditis bacteriophora and its symbiotic bacterium, Photorhabdus luminescens, are important biological control agents of insect pests. This nematode-bacterium-insect association represents an emerging tripartite model for research on mutualistic and parasitic symbioses. Elucidation of mechanisms underlying these biological processes may serve as a foundation for improving the biological control potential of the nematode-bacterium complex. This large-scale expressed sequence tag (EST) analysis effort enables gene discovery and development of microsatellite markers. These ESTs will also aid in the annotation of the upcoming complete genome sequence of H. bacteriophora. Results: A total of 31,485 high quality ESTs were generated …

The Case Of The Silent Crippler, Amanda Orme, Karlen E. (Beth) Luthy

Faculty Publications

Thirteen-year-old “Stephanie” has been complaining of bilateral leg pain and increasing lower extremity weakness. Stephanie's teacher recently approached her parents to inform them of concerns that Stephanie is walking differently and seems off balance at school.

Ionic Selectivity In L-Type Calcium Channels By Electrostatics And Hard-Core Repulsion, Dezso Boda, Douglas Henderson, Monika Valisko, Bob Eisenberg, Dirk Gillespie

Faculty Publications

A physical model of selective "ion binding" in the L-type calcium channel is constructed, and consequences of the model are compared with experimental data. This reduced model treats only ions and the carboxylate oxygens of the EEEE locus explicitly and restricts interactions to hard-core repulsion and ion–ion and ion–dielectric electrostatic forces. The structural atoms provide a flexible environment for passing cations, thus resulting in a self-organized induced-fit model of the selectivity filter. Experimental conditions involving binary mixtures of alkali and/or alkaline earth metal ions are computed using equilibrium Monte Carlo simulations in the grand canonical ensemble. The model pore rejects …

Ultrasonic Drug Delivery To Tumors Via Stealth Liposomes, Peter Jones, Ghaleb A. Husseini, William G. Pitt, Beverly L. Roeder

Faculty Publications

Our research develops ultrasonically-controlled drug delivery systems. Previous micellar drug carriers released the drug upon ultrasonication. We have developed a liposomal drug carrier that is even more effective upon insonation in reducing tumors.

The Structure Of A Receptor With Two Associating Transmembrane Domains On The Cell Surface: Integrin ΑIibΒ3, Jieqing Zhu, Bing Hao Luo, Patrick Barth, Jack Schonbrun, David Baker, Timothy A. Springer

Faculty Publications

Structures of intact receptors with single-pass transmembrane domains are essential to understand how extracellular and cytoplasmic domains regulate association and signaling through transmembrane domains. A chemical and computational method to determine structures of the membrane regions of such receptors on the cell surface is developed here and validated with glycophorin A. An integrin heterodimer structure reveals association over most of the lengths of the α and β transmembrane domains and shows that the principles governing association of hetero and homo transmembrane dimers differ. A turn at the Gly of the juxtamembrane GFFKR motif caps the α TM helix and brings …

Evolutionary Conserved Motif Finder (Ecmfinder) For Genome-Wide Identification Of Clustered Yy1- And Ctcf-Binding Sites, Keunsoo Kang, Jae Hoon Chung, Joomyeong Kim

Faculty Publications

We have developed a new bioinformatics approach called ECMFinder (Evolutionary Conserved Motif Finder). This program searches for a given DNA motif within the entire genome of one species and uses the gene association information of a potential transcription factor-binding site (TFBS) to screen the homologous regions of a second and third species. If multiple species have this potential TFBS in homologous positions, this program recognizes the identified TFBS as an evolutionary conserved motif (ECM). This program outputs a list of ECMs, which can be uploaded as a Custom Track in the UCSC genome browser and can be visualized along with …

Universal Constant For Heat Production In Protists, Matthew D. Johnson, Jens Völker, Holly V. Moeller, Edward Laws, Kenneth J. Breslauer, Paul G. Falkowski

Faculty Publications

Using a high sensitivity differential scanning calorimeter in isothermal mode, we directly measured heat production in eukaryotic protists from 5 phyla spanning over 5 orders of magnitude in carbon biomass and 8 orders of magnitude in cell volume. Our results reveal that metabolic heat production normalized to cell mass is virtually constant in these organisms, with a median of 0.037 pW pg C ^-1 (95% confidence interval = 0.022-0.061 pW pg C ^-1) at 5 °C. Contrary to allometric models, the relationship between heat production and cell carbon content or surface area is isometric (scaling exponents, 1.056 and 1.057, …

The Risk Of Developing A Second Cancer After Receiving Craniospinal Proton Irradiation, Wayne D. Newhauser, Jonas D. Fontenot, Anita Mahajan, David Kornguth, Marilyn Stovall, Yuanshui Zheng, Phillip J. Taddei, Dragan Mirkovic, Radhe Mohan, James D. Cox, Shiao Woo

Faculty Publications

The purpose of this work was to compare the risk of developing a second cancer after craniospinal irradiation using photon versus proton radiotherapy by means of simulation studies designed to account for the effects of neutron exposures. Craniospinal irradiation of a male phantom was calculated for passively-scattered and scanned-beam proton treatment units. Organ doses were estimated from treatment plans; for the proton treatments, the amount of stray radiation was calculated separately using the Monte Carlo method. The organ doses were converted to risk of cancer incidence using a standard formalism developed for radiation protection purposes. The total lifetime risk of …

Stray Radiation Dose And Second Cancer Risk For A Pediatric Patient Receiving Craniospinal Irradiation With Proton Beams, Phillip J. Taddei, Dragan Mirkovic, Jonas D. Fontenot, Annelise Giebeler, Yuanshui Zheng, David Kornguth, Radhe Mohan, Wayne D. Newhauser

Faculty Publications

Proton beam radiotherapy unavoidably exposes healthy tissue to stray radiation emanating from the treatment unit and secondary radiation produced within the patient. These exposures provide no known benefit and may increase a patient's risk of developing a radiogenic cancer. The aims of this study were to calculate doses to major organs and tissues and to estimate second cancer risk from stray radiation following craniospinal irradiation (CSI) with proton therapy. This was accomplished using detailed Monte Carlo simulations of a passive-scattering proton treatment unit and a voxelized phantom to represent the patient. Equivalent doses, effective dose and corresponding risk for developing …

Environmentally Persistent Free Radicals Amplify Ultrafine Particle Mediated Cellular Oxidative Stress And Cytotoxicity, Shrilatha Balakrishna, Slawo Lomnicki, Kevin M. Mcavey, Richard B. Cole, Barry Dellinger, Stephania A. Cormier

Faculty Publications

Background: Combustion generated particulate matter is deposited in the respiratory tract and pose a hazard to the lungs through their potential to cause oxidative stress and inflammation. We have previously shown that combustion of fuels and chlorinated hydrocarbons produce semiquinone-type radicals that are stabilized on particle surfaces (i.e. environmentally persistent free radicals; EPFRs). Because the composition and properties of actual combustion-generated particles are complex, heterogeneous in origin, and vary from day-to-day, we have chosen to use surrogate particle systems. In particular, we have chosen to use the radical of 2-monochlorophenol (MCP230) as the EPFR because we have previously shown that …

Occurrence Of Mitochondria-Targeted Late Embryogenesis Abundant (Lea) Gene In Animals Increases Organelle Resistance To Water Stress, Michael A. Menze, Leaf Boswell, Mehmet Toner, Steven C. Hand

Faculty Publications

Anhydrobiotic animals survive virtually complete loss of cellular water. The mechanisms that explain this phenomenon are not fully understood but often include the accumulation of low molecular weight solutes such as trehalose and macromolecules like Late Embryogenesis Abundant (LEA) proteins. Here we report for the first time the occurrence of a mitochondria-targeted LEA gene (Afrlea3m) product in an animal species. The deduced molecular mass of the 307-amino acid polypeptide from the brine shrimp Artemia franciscana is 34 kDa. Bioinformatic analyses reveal features typical of a Group 3 LEA protein, and subcellular localization programs predict targeting of the mature peptide to …