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Virus-Derived Sirnas And Pirnas In Immunity And Pathogenesis, Shou Wei Ding, Rui Lu Jan 2011

Virus-Derived Sirnas And Pirnas In Immunity And Pathogenesis, Shou Wei Ding, Rui Lu

Faculty Publications

Cellular organisms have evolved related pathways for the biogenesis and function of small interfering RNAs (siRNAs), microRNAs and PIWI-interacting RNAs (piRNAs). These distinct classes of small RNAs guide specific gene silencing at both transcriptional and posttranscriptional levels by serving as specificity determinants. Small RNAs of virus and host origins have been found to modulate virus-host interactions by RNA interference (RNAi), leading to antiviral immunity or viral pathogenesis. Deep sequencing-based profiling of virus-derived small RNAs as products of host immune recognition not only allowed us to gain insight into the expansion and functional specialization of host factors involved in the antiviral …

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Automated Scanning Probe Lithography With N-Alkanethiol Self-Assembled Monolayers On Au(111): Application For Teaching Undergraduate Laboratories, Treva T. Brown, Zorabel M. Lejeune, Kai Liu, Sean Hardin, Jie Ren Li, Kresimir Rupnik, Jayne C. Garno Jan 2011

Automated Scanning Probe Lithography With N-Alkanethiol Self-Assembled Monolayers On Au(111): Application For Teaching Undergraduate Laboratories, Treva T. Brown, Zorabel M. Lejeune, Kai Liu, Sean Hardin, Jie Ren Li, Kresimir Rupnik, Jayne C. Garno

Faculty Publications

Controllers for scanning probe instruments can be programmed for automated lithography to generate desired surface arrangements of nanopatterns of organic thin films, such as n-alkanethiol self-assembled monolayers (SAMs). In this report, atomic force microscopy (AFM) methods of lithography known as nanoshaving and nano-grafting are used to write nanopatterns within organic thin films. Commercial instruments provide software to control the length, direction, speed, and applied force of the scanning motion of the tip. For nanoshaving, higher forces are applied to an AFM tip to selectively remove regions of the matrix monolayer, exposing bare areas of the gold substrate. Nanografting is accomplished …

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Oncogenic Potential Of Yin Yang 1 Mediated Through Control Of Imprinted Genes, Michelle M. Thiaville, Joomyeong Kim Jan 2011

Oncogenic Potential Of Yin Yang 1 Mediated Through Control Of Imprinted Genes, Michelle M. Thiaville, Joomyeong Kim

Faculty Publications

The transcription factor Yin Yang (YY) 1 is one of the most evolutionarily well-conserved DNA binding proteins that is ubiquitously expressed among different tissue types. YY1 functions as a critical regulator for a diverse set of genes, making its role in the cancerous environment elusive. Recent studies have demonstrated that clusters of YY1 binding sites are overrepresented in imprinted gene loci. These clustered binding sites may function as a molecular rheostat with respect to YY1 protein levels. YY1 levels were documented to be altered in various tumor tissues in conjunction with the transcriptional levels of the imprinted genes it regulates. …

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The Large Decapitating Fly Pseudacteon Litoralis (Diptera: Phoridae): Successfully Established On Fire Ant Populations In Alabama, Sanford D. Porter, L. C. Graham, Seth J. Johnson, Larry G. Thead, Juan A. Briano Jan 2011

The Large Decapitating Fly Pseudacteon Litoralis (Diptera: Phoridae): Successfully Established On Fire Ant Populations In Alabama, Sanford D. Porter, L. C. Graham, Seth J. Johnson, Larry G. Thead, Juan A. Briano

Faculty Publications

The large fire ant decapitating fly, Pseudacteon litoralis Borgmeier, from northeastern Argentina was successfully released as a self-sustaining biocontrol agent of imported fire ants in south central Alabama in 2005. Five years later, this fly is firmly established at the original release site and has expanded outward at least 18 km. Nevertheless, populations remain very low considering P. litoralis is one of the most abundant fire ant decapitating flies in large areas of its range in South America. The reasons for low densities and why we were only able to establish this fly at 1 of 9 release sites in …

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Five Blood Pressure Loci Identified By An Updated Genome-Wide Linkage Scan: Meta-Analysis Of The Family Blood Pressure Program, Jeannette Simino, Gang Shi, Rezart Kume, Karen Schwander, Michael A. Province, C. Charles Gu, Sharon Kardia, Aravinda Chakravarti, Georg Ehret, Richard A. Olshen, Stephen T. Turner, Low Tone Ho, Xiaofeng Zhu, Cashell Jaquish, Dina Paltoo, Richard S. Cooper, Alan Weder, J. David Curb, Eric Boerwinkle, Steven C. Hunt, Dabeeru C. Rao Jan 2011

Five Blood Pressure Loci Identified By An Updated Genome-Wide Linkage Scan: Meta-Analysis Of The Family Blood Pressure Program, Jeannette Simino, Gang Shi, Rezart Kume, Karen Schwander, Michael A. Province, C. Charles Gu, Sharon Kardia, Aravinda Chakravarti, Georg Ehret, Richard A. Olshen, Stephen T. Turner, Low Tone Ho, Xiaofeng Zhu, Cashell Jaquish, Dina Paltoo, Richard S. Cooper, Alan Weder, J. David Curb, Eric Boerwinkle, Steven C. Hunt, Dabeeru C. Rao

Faculty Publications

Background A preliminary genome-wide linkage analysis of blood pressure in the Family Blood Pressure Program (FBPP) was reported previously. We harnessed the power and ethnic diversity of the final pooled FBPP dataset to identify novel loci for blood pressure thereby enhancing localization of genes containing less common variants with large effects on blood pressure levels and hypertension.MethodsWe performed one overall and 4 race-specific meta-analyses of genome-wide blood pressure linkage scans using data on 4,226 African-American, 2,154 Asian, 4,229 Caucasian, and 2,435 Mexican-American participants (total N = 13,044). Variance components models were fit to measured (raw) blood pressure levels and two …

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Reverse Causation And Illness-Related Weight Loss In Observational Studies Of Body Weight And Mortality, Katherine M. Flegal, Barry I. Graubard, David F. Williamson, Richard S. Cooper Jan 2011

Reverse Causation And Illness-Related Weight Loss In Observational Studies Of Body Weight And Mortality, Katherine M. Flegal, Barry I. Graubard, David F. Williamson, Richard S. Cooper

Faculty Publications

In studies of weight and mortality, the construct of reverse causation has come to be used to imply that the exposure-outcome relation is biased by weight loss due to preexisting illness. Observed weight-mortality associations are sometimes thought to result from this bias. Evidence for the occurrence of such bias is weak and inconsistent, suggesting that either the analytical methods used have been inadequate or else illness-related weight loss is not an important source of bias. Deleting participants has been the most frequent approach to control possible bias. As implemented, this can lead to deletion of almost 90% of all deaths …

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Source Reduction Behavior As An Independent Measurement Of The Impact Of A Public Health Education Campaign In An Integrated Vector Management Program For The Asian Tiger Mosquito, Kristen Bartlett-Healy, George Hamilton, Sean Healy, Taryn Crepeau, Isik Unlu, Ary Farajollahi, Dina Fonseca, Randy Gaugler, Gary G. Clark, Daniel Strickman Jan 2011

Source Reduction Behavior As An Independent Measurement Of The Impact Of A Public Health Education Campaign In An Integrated Vector Management Program For The Asian Tiger Mosquito, Kristen Bartlett-Healy, George Hamilton, Sean Healy, Taryn Crepeau, Isik Unlu, Ary Farajollahi, Dina Fonseca, Randy Gaugler, Gary G. Clark, Daniel Strickman

Faculty Publications

The goal of this study was to evaluate the effectiveness of a public health educational campaign to reduce backyard mosquito-larval habitats. Three communities each, within two New Jersey counties, were randomly selected to receive: (1) both education and mosquito control, (2) education only, and (3) no education or mosquito control. Four separate educational events included a 5-day elementary school curriculum in the spring, and three door to door distributions of educational brochures. Before and after each educational event, the numbers of mosquito-larval container habitats were counted in 50 randomly selected homes per study area. Container surveys allowed us to measure …

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On The Origin Of Stories: Evolution, Cognition, And Fiction, Hope Hollocher, Agustín Fuentes, Charles H. Pence, Grant Ramsey, Daniel John Sportiello, Michelle M. Wirth Jan 2011

On The Origin Of Stories: Evolution, Cognition, And Fiction, Hope Hollocher, Agustín Fuentes, Charles H. Pence, Grant Ramsey, Daniel John Sportiello, Michelle M. Wirth

Faculty Publications

No abstract provided.

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“Describing Our Whole Experience”: The Statistical Philosophies Of W.F.R. Weldon And Karl Pearson, Charles H. Pence Jan 2011

“Describing Our Whole Experience”: The Statistical Philosophies Of W.F.R. Weldon And Karl Pearson, Charles H. Pence

Faculty Publications

There are two motivations commonly ascribed to historical actors for taking up statistics: to reduce complicated data to a mean value (e.g., Quetelet), and to take account of diversity (e.g., Galton). Different motivations will, it is assumed, lead to different methodological decisions in the practice of the statistical sciences. Karl Pearson and W. F. R. Weldon are generally seen as following directly in Galton’s footsteps. I argue for two related theses in light of this standard interpretation, based on a reading of several sources in which Weldon, independently of Pearson, reflects on his own motivations. First, while Pearson does approach …

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Nietzsche’S Aesthetic Critique Of Darwin, Charles H. Pence Jan 2011

Nietzsche’S Aesthetic Critique Of Darwin, Charles H. Pence

Faculty Publications

Despite his position as one of the first philosophers to write in the “post- Darwinian” world, the critique of Darwin by Friedrich Nietzsche is often ignored for a host of unsatisfactory reasons. I argue that Nietzsche’s critique of Darwin is important to the study of both Nietzsche’s and Darwin’s impact on philosophy. Further, I show that the central claims of Nietzsche’s critique have been broadly misunderstood. I then present a new reading of Nietzsche’s core criticism of Darwin. An important part of Nietzsche’s response can best be understood as an aesthetic critique of Darwin, reacting to what he saw as …

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Influence Of Cortisol On The Attachment And Metamorphosis Of Larval Utterbackia Imbecillis On Bluegill Sunfish (Lepomis Macrochirus), Benjamin Dubansky, Brian Whitaker, Fernando Galvez Jan 2011

Influence Of Cortisol On The Attachment And Metamorphosis Of Larval Utterbackia Imbecillis On Bluegill Sunfish (Lepomis Macrochirus), Benjamin Dubansky, Brian Whitaker, Fernando Galvez

Faculty Publications

The larvae of unionid freshwater mussels (i.e., glochidia) undergo a parasitic stage requiring their attachment to the external epithelia of fish hosts, where they metamorphose into free-living juveniles. We describe the physiological effects in bluegill sunfish (Lepomis macrochirus) of infection with glochidia from the paper pondshell (Utterbackia imbecillis). Glochidia accumulation on bluegill increased dramatically at concentrations of 2000 glochidia liter-1 and above, reaching a maximum attachment density of about 30 glochidia g-1 fish at 4000 glochidia liter-1. Plasma cortisol was the most sensitive indicator of biological effect to glochidial exposure, increasing significantly in hosts exposed to 2000 glochidia liter-1 or …

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Outlook For Development Of High-Throughput Cryopreservation For Small-Bodied Biomedical Model Fishes, Terrence R. Tiersch, Huiping Yang, E. Hu Jan 2011

Outlook For Development Of High-Throughput Cryopreservation For Small-Bodied Biomedical Model Fishes, Terrence R. Tiersch, Huiping Yang, E. Hu

Faculty Publications

With the development of genomic research technologies, comparative genome studies among vertebrate species are becoming commonplace for human biomedical research. Fish offer unlimited versatility for biomedical research. Extensive studies are done using these fish models, yielding tens of thousands of specific strains and lines, and the number is increasing every day. Thus, high-throughput sperm cryopreservation is urgently needed to preserve these genetic resources. Although high-throughput processing has been widely applied for sperm cryopreservation in livestock for decades, application in biomedical model fishes is still in the concept-development stage because of the limited sample volumes and the biological characteristics of fish …

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Sperm Quality Assessments For Endangered Razorback Suckers Xyrauchen Texanus, Jill A. Jenkins, Bruce E. Eilts, Amy M. Guitreau, Chester R. Figiel, Rassa O. Draugelis-Dale, Terrence R. Tiersch Jan 2011

Sperm Quality Assessments For Endangered Razorback Suckers Xyrauchen Texanus, Jill A. Jenkins, Bruce E. Eilts, Amy M. Guitreau, Chester R. Figiel, Rassa O. Draugelis-Dale, Terrence R. Tiersch

Faculty Publications

Flow cytometry (FCM) and computer-assisted sperm motion analysis (CASA) methods were developed and validated for use with endangered razorback suckers Xyrauchen texanus collected (nZ64) during the 2006 spawning season. Sperm motility could be activated within osmolality ranges noted during milt collections (here 167-343 mOsm/kg). We hypothesized that sperm quality of milt collected into isoosmotic (302 mOsm/kg) or hyperosmotic (500 mOsm/kg) Hanks' balanced salt solution would not differ. Pre-freeze viabilities were similar between osmolalities (79%G6 (S.E.M.) and 76%G7); however, post-thaw values were greater in hyperosmotic buffer (27%G3 and 12%G2; PZ0.0065), as was mitochondrial membrane potential (33%G4 and 13%G2; PZ0.0048). Visual estimates …

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Smoking Behavior And Alcohol Consumption In Individuals With Panic Attacks, Amanda R. Mathew, Peter J. Norton, Michael J. Zvolensky, Julia D. Buckner, Jasper A.J. Smits Jan 2011

Smoking Behavior And Alcohol Consumption In Individuals With Panic Attacks, Amanda R. Mathew, Peter J. Norton, Michael J. Zvolensky, Julia D. Buckner, Jasper A.J. Smits

Faculty Publications

Individuals with anxiety often report greater smoking and drinking behaviors relative to those without a history of anxiety. In particular, smoking and alcohol use have been directly implicated among individuals experiencing panic attacks, diagnosed with panic disorder, or high on panic-relevant risk factors such as anxiety sensitivity. Less is known, however, about specific features of panic that may differentiate among those who do or do not use cigarettes or alcohol. The purpose of the current study was to replicate previous research findings of an association between panic symptomatology, cigarette smoking, and alcohol consumption, as well as extend findings by examining …

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Habitat Use Does Not Reflect Habitat Quality For Henslow's Sparrows (Ammodramus Henslowii) Wintering In Fire-Managed Longleaf Pine Savannas, Erik I. Johnson, Jennifer K. Dimiceli, Philip C. Stouffer, Matthew E. Brooks Jan 2011

Habitat Use Does Not Reflect Habitat Quality For Henslow's Sparrows (Ammodramus Henslowii) Wintering In Fire-Managed Longleaf Pine Savannas, Erik I. Johnson, Jennifer K. Dimiceli, Philip C. Stouffer, Matthew E. Brooks

Faculty Publications

Interpreting habitat quality requires an understanding of the consequences of habitat use because bird density alone may not reflect habitat quality. Although habitat use can be readily quantified, subsequent effects remain elusive for most species, especially for migrants on the wintering grounds. Wintering Henslow's Sparrow (Ammodramus henslowii) densities in Longleaf Pine (Pinus palustris) savannas are fire-dependent, with highest bird densities in the first winter after a fire, but reduced density in subsequent winters without fire. We determined habitat characteristics associated with variation in bird density in the first and second winters following fire and then followed birds' diet, condition, and …

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Diversification Of An Endemic Southeast Asian Genus: Phylogenetic Relationships Of The Spiderhunters (Nectariniidae: Arachnothera), Robert G. Moyle, Sabrina S. Taylor, Carl H. Oliveros, Haw Chuan Lim, Cheryl L. Haines, Mustafa A. Rahman, Frederick H. Sheldon Jan 2011

Diversification Of An Endemic Southeast Asian Genus: Phylogenetic Relationships Of The Spiderhunters (Nectariniidae: Arachnothera), Robert G. Moyle, Sabrina S. Taylor, Carl H. Oliveros, Haw Chuan Lim, Cheryl L. Haines, Mustafa A. Rahman, Frederick H. Sheldon

Faculty Publications

The phylogeny of spiderhunters (Nectariniidae: Arachnothera) was reconstructed by comparing mitochondrial and nuclear DNA sequences of all currently recognized species and with broad geographic sampling of two particularly variable species complexes, the Little Spiderhunter (Arachnothera longirostra) and the streaky spiderhunters (A. modesta and A. affinis). It appears to be a relatively old group, whose diversification was not caused by recent sea-level changes. However, the modern, highly sympatric distribution of the large species in the Sunda lowlands was probably a result of dispersal via recent land bridges. Within the highly variable A. longirostra group, there are substantially diverged taxa in the …

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Raft Formation By The Red Imported Fire Ant, Solenopsis Invicta, Benjamin J. Adams, Linda M. Hooper-Bùi, Rachel M. Strecker, Daniel M. O'Brien Jan 2011

Raft Formation By The Red Imported Fire Ant, Solenopsis Invicta, Benjamin J. Adams, Linda M. Hooper-Bùi, Rachel M. Strecker, Daniel M. O'Brien

Faculty Publications

Abstract The raft behavior of the invasive red imported fire ant, Solenopsis invicta Buren (Hymenoptera: Formicidae), has been documented for over a century. However, no rigorous tests have been performed elucidating the structure, limits, and important characteristics of this behavior. Rafting makes S. invicta competitive in both native and foreign environments. Further understanding of this behavior will provide critical advancement to the comprehension of this ant's global invasion ecology. Though speculations exist, no one has looked at the movements of individuals within the raft formation, the longevity of rafts, raft success rate, or the importance of different life stages and …

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The Rights And Liberties Of The Palau Constitution, Kevin Bennardo Jan 2011

The Rights And Liberties Of The Palau Constitution, Kevin Bennardo

Faculty Publications

No abstract provided.

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Auxin Regulation Of Arabidopsis Flower Development Involves Members Of The Aintegumenta-Like/Plethora (Ail/Plt) Family, Beth A. Krizek Jan 2011

Auxin Regulation Of Arabidopsis Flower Development Involves Members Of The Aintegumenta-Like/Plethora (Ail/Plt) Family, Beth A. Krizek

Faculty Publications

Auxin is an important regulator of many aspects of plant growth and development. During reproductive development, auxin specifies the site of flower initiation and subsequently regulates organ growth and patterning as well as later events that determine reproductive success. Underlying auxin action in plant tissues is its uneven distribution, resulting in groups of cells with high auxin levels (auxin maxima) or graded distributions of the hormone (auxin gradients). Dynamic auxin distribution within the periphery of the inflorescence meristems specifies the site of floral meristem initiation, while auxin maxima present at the tips of developing floral organ primordia probably mediate organ …

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Santa Clara Law 1911-2010: Centennial Faculty Bibliography, Mary D. Hood Jan 2011

Santa Clara Law 1911-2010: Centennial Faculty Bibliography, Mary D. Hood

Faculty Publications

Faculty scholarship represents the intellectual life of a law school. To feature our faculty‟s scholarly efforts, the reference staff at Heafey Law Library maintains a database of the published scholarship of full-time faculty and other academic staff currently in residence at Santa Clara Law. This database consists of all publications of faculty through their tenure at Santa Clara. As the law school began to make plans to celebrate its centennial birthday it seemed appropriate for the law library to contribute to the occasion. What more fitting way to mark this historic milestone than to have the library staff create a …

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Interring The Pioneer Invention Doctrine, Brian J. Love Jan 2011

Interring The Pioneer Invention Doctrine, Brian J. Love

Faculty Publications

This Article provides the first comprehensive analysis of patent law's "pioneer invention doctrine" in almost two decades. Since the early 1990s, patent scholars have unanimously reported that case law favoring so-called "pioneer" patents-i.e., those disclosing the most revolutionary inventions-is dead letter. Accordingly, most scholars have ignored the pioneer doctrine entirely. Those few who have studied it have consistently argued that the doctrine ought to be raised from the dead and reintroduced to patent law. This Article refutes scholarly consensus on both points. First, empirical evidence shows that the pioneer doctrine is still very much good law, especially at the district …

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Coupling In Vitro And In Vivo Paradigm Reveals A Dose Dependent Inhibition Of Angiogenesis Followed By Initiation Of Autophagy By C6-Ceramide, Rishipal R. Bansode, Mohamed Ahmedna, Kurt R. Svoboda, Jack N. Losso Jan 2011

Coupling In Vitro And In Vivo Paradigm Reveals A Dose Dependent Inhibition Of Angiogenesis Followed By Initiation Of Autophagy By C6-Ceramide, Rishipal R. Bansode, Mohamed Ahmedna, Kurt R. Svoboda, Jack N. Losso

Faculty Publications

The activity of N-hexanoyl-D-erythro-sphingosine, a C6-ceramide against angiogenesis was tested in vitro and in vivo. The effect of ceramide in inhibiting MCF-7 cancer cells was also determined. The aim of this study was to potentiate the effect of ceramide as an-ti-angiogenic compound that can regulate tumor induced angiogenesis. C6-ceramide inhibited vascular endothelial growth factor (VEGF)-induced human um-bilical vein endothelial cells (HUVEC) tube formation in a dose-dependent manner within 24 hours. Ceramide at concentrations between 12.5 and 25 μM inhibited the via-bility of MCF-7 cells and reduced VEGF-induced cell migration in 24 hours. At 50 μM, ceramide induced MCF-7 cell death …

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Spatio-Temporal Analysis Of Crime Hotspots By Trajectories And Self-Organizing Maps, Marco Helbich, Julian Hagenauer, Michael Leitner Jan 2011

Spatio-Temporal Analysis Of Crime Hotspots By Trajectories And Self-Organizing Maps, Marco Helbich, Julian Hagenauer, Michael Leitner

Faculty Publications

The exploration of spatial relationships between crime incidents, the socio-economic characteristics of neighborhoods, as well as physical and structural compositions of the urban landscape is an ongoing research issue in Geographic Information Science. Spatial data mining tools improve the ability to gain knowledge from geographic data and help to understand spatio-temporal processes that contribute to the presence or absence of criminal offenses. However, most of the currently available tools focus either on the spatial, the temporal, or a combination of both aspects. But crime has a spatial and temporal component in a multidimensional attribute space. Therefore, it is reasonable to …

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Should I Stay Or Should I Go: Why Immigrant Reunification Decisions Should Be Based On The Best Interest Of The Child, Marcia A. Yablon-Zug Jan 2011

Should I Stay Or Should I Go: Why Immigrant Reunification Decisions Should Be Based On The Best Interest Of The Child, Marcia A. Yablon-Zug

Faculty Publications

No abstract provided.

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Notional Generosity: Explaining Charitable Donors' High Willingness To Part With Conservation Easements, Josh Eagle Jan 2011

Notional Generosity: Explaining Charitable Donors' High Willingness To Part With Conservation Easements, Josh Eagle

Faculty Publications

No abstract provided.

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Analysis Of Electrodeposited Nickel-Iron Alloy Film Composition Using Particle-Induced X-Ray Emission, Alyssa Frey, Nicholas Wozniak, Timothy Nagi, Matthew Keller, J. Mark Lunderberg, Graham F. Peaslee, Paul Deyoung, Jennifer R. Hampton Jan 2011

Analysis Of Electrodeposited Nickel-Iron Alloy Film Composition Using Particle-Induced X-Ray Emission, Alyssa Frey, Nicholas Wozniak, Timothy Nagi, Matthew Keller, J. Mark Lunderberg, Graham F. Peaslee, Paul Deyoung, Jennifer R. Hampton

Faculty Publications

The elemental composition of electrodeposited NiFe thin films was analyzed with particle-induced X-ray emission (PIXE). The thin films were electrodeposited on polycrystalline Au substrates from a 100mM NiSO4, 10 mM FeSO4, 0.5M H3BO3, and 1M Na2SO4 solution. PIXE spectra of these films were analyzed to obtain relative amounts of Ni and Fe as a function of deposition potential and deposition time. The results show that PIXE can measure the total deposited metal in a sample over at least four orders of magnitude with similar fractional uncertainties. The technique is …

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Obesity And Overweight Prevalence Among A Mississippi Low-Income Preschool Population: A Five-Year Comparison, Bonnie Harbaugh, Jerome R. Kolbo, Elaine F. Molaison, Geoffrey M. Hudson, Lei Zhang, Danyell Wells Jan 2011

Obesity And Overweight Prevalence Among A Mississippi Low-Income Preschool Population: A Five-Year Comparison, Bonnie Harbaugh, Jerome R. Kolbo, Elaine F. Molaison, Geoffrey M. Hudson, Lei Zhang, Danyell Wells

Faculty Publications

Purpose. This study determined 2010 rates of overweight/obesity in a representative sample of low-income preschoolers in Mississippi, USA and compared rates between 2005 (� = 1 2 5 0) and 2010 (� = 1 7 6 5). Significance. Obesity is a significant global health issue because of its well-established negative health consequences. Child obesity is a concern due to risk of early-onset obesity-related illnesses and the longevity of lifetime exposure to those illnesses. Methods. Identical measures were used in 2005 and 2010 with complex-stratified sampling designs. Results. Chi-square tests revealed that overall obesity/overweight rates between 2005 (20.6%/17.9%) and 2010 (20.8%/17.0%) …

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Coastal Watershed Connections; Student Impact, Stewardship, And Reflections, Sherry S. Herron, Shelia A. Brown Jan 2011

Coastal Watershed Connections; Student Impact, Stewardship, And Reflections, Sherry S. Herron, Shelia A. Brown

Faculty Publications

The project provided students and teachers in six coastal and noncoastal Title 1 secondary schools in Mississippi with experiential learning activities to emphasize connections between their local watershed an coastal habitats of the Gulf of Mexico using GLOBE (Global Learning and Observations to Benefit the Environment) protocols, OBIS (Outdoor Biology Instruction Strategies) Science and service-learning projects.

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Characterization Of Plasmid Dna Location Within Chitosan/Plga/Pdna Nanoparticle Complexes Designed For Gene Delivery, Hali Bordelon, Alexandru S. Biris, Cristina M. Sabliov, W. Todd Monroe Jan 2011

Characterization Of Plasmid Dna Location Within Chitosan/Plga/Pdna Nanoparticle Complexes Designed For Gene Delivery, Hali Bordelon, Alexandru S. Biris, Cristina M. Sabliov, W. Todd Monroe

Faculty Publications

Poly(D,L-lactide-co-glycolide-) (PLGA-)chitosan nanoparticles are becoming an increasingly common choice for the delivery of nucleic acids to cells for various genetic manipulation techniques. These particles are biocompatible, with tunable size and surface properties, possessing an overall positive charge that promotes complex formation with negatively charged nucleic acids. This study examines properties of the PLGA-chitosan nanoparticle/plasmid DNA complex after formation. Specifically, the study aims to determine the optimal ratio of plasmid DNA:nanoparticles for nucleic acid delivery purposes and to elucidate the location of the pDNA within these complexes. Such characterization will be necessary for the adoption of these formulations in a clinical …

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Computational Prediction Of Heme-Binding Residues By Exploiting Residue Interaction Network, R. Liu, Jianjun Hu Jan 2011

Computational Prediction Of Heme-Binding Residues By Exploiting Residue Interaction Network, R. Liu, Jianjun Hu

Faculty Publications

Computational identification of heme-binding residues is beneficial for predicting and designing novel heme proteins. Here we proposed a novel method for heme-binding residue prediction by exploiting topological properties of these residues in the residue interaction networks derived from three-dimensional structures. Comprehensive analysis showed that key residues located in heme-binding regions are generally associated with the nodes with higher degree, closeness and betweenness, but lower clustering coefficient in the network. HemeNet, a support vector machine (SVM) based predictor, was developed to identify heme-binding residues by combining topological features with existing sequence and structural features. The results showed that incorporation of network-based …

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