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Il-4rα On Cd4+ T Cells Plays A Pathogenic Role In Respiratory Syncytial Virus Reinfection In Mice Infected Initially As Neonates, Dahui You, Nico Marr, Jordy Saravia, Bishwas Shrestha, Greg I. Lee, Stuart E. Turvey, Frank Brombacher, De'broski R. Herbert, Stephania A. Cormier Jun 2013

Il-4rα On Cd4+ T Cells Plays A Pathogenic Role In Respiratory Syncytial Virus Reinfection In Mice Infected Initially As Neonates, Dahui You, Nico Marr, Jordy Saravia, Bishwas Shrestha, Greg I. Lee, Stuart E. Turvey, Frank Brombacher, De'broski R. Herbert, Stephania A. Cormier

Faculty Publications

RSV is the major cause of severe bronchiolitis in infants, and severe bronchiolitis as a result of RSV is associated with subsequent asthma development. A biased Th2 immune response is thought to be responsible for neonatal RSV pathogenesis; however, molecular mechanisms remain elusive. Our data demonstrate, for the first time, that IL-4Rα is up-regulated in vitro on human CD4+ T cells from cord blood following RSV stimulation and in vivo on mouse pulmonary CD4+ T cells upon reinfection of mice, initially infected as neonates. Th cell-specific deletion of Il4ra attenuated Th2 responses and abolished the immunopathophysiology upon reinfection, including airway …

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Fitness: Philosophical Problems, Grant Ramsey, Charles H. Pence Jun 2013

Fitness: Philosophical Problems, Grant Ramsey, Charles H. Pence

Faculty Publications

Fitness plays many roles throughout evolutionary theory, from a measure of populations in the wild to a central element in abstract theoretical presentations of natural selection. It has thus been the subject of an extensive philosophical literature, which has primarily centred on the way to understand the relationship between fitness values and reproductive outcomes. If fitness is a probabilistic or statistical quantity, how is it to be defined in general theoretical contexts? How can it be measured? Can a single conceptual model for fitness be offered that applies to all biological cases, or must fitness measures be case-specific? Philosophers have …

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Reevaluating The Conceptual Framework For Applied Research On Host-Plant Resistance, Michael J. Stout Jun 2013

Reevaluating The Conceptual Framework For Applied Research On Host-Plant Resistance, Michael J. Stout

Faculty Publications

Applied research on host-plant resistance to arthropod pests has been guided over the past 60 years by a framework originally developed by Reginald Painter in his 1951 book, Insect Resistance in Crop Plants. Painter divided the "phenomena" of resistance into three "mechanisms," nonpreference (later renamed antixenosis), antibiosis, and tolerance. The weaknesses of this framework are discussed. In particular, this trichotomous framework does not encompass all known mechanisms of resistance, and the antixenosis and antibiosis categories are ambiguous and inseparable in practice. These features have perhaps led to a simplistic approach to understanding arthropod resistance in crop plants. A dichotomous scheme …

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The Genomic Consequences Of Adaptive Divergence And Reproductive Isolation Between Species Of Manakins, T. L. Parchman, Z. Gompert, M. J. Braun, R. T. Brumfield, D. B. Mcdonald, J. A.C. Uy, G. Zhang, E. D. Jarvis, B. A. Schlinger, C. A. Buerkle Jun 2013

The Genomic Consequences Of Adaptive Divergence And Reproductive Isolation Between Species Of Manakins, T. L. Parchman, Z. Gompert, M. J. Braun, R. T. Brumfield, D. B. Mcdonald, J. A.C. Uy, G. Zhang, E. D. Jarvis, B. A. Schlinger, C. A. Buerkle

Faculty Publications

The processes of adaptation and speciation are expected to shape genomic variation within and between diverging species. Here we analyze genomic heterogeneity of genetic differentiation and introgression in a hybrid zone between two bird species (Manacus candei and M. vitellinus) using 59 100 SNPs, a whole genome assembly, and Bayesian models. Measures of genetic differentiation (FST) and introgression (genomic cline center [α] and rate [β]) were highly heterogeneous among loci. We identified thousands of loci with elevated parameter estimates, some of which are likely to be associated with variation in fitness in Manacus populations. To analyze the genomic organization of …

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Savage Minds Interview: Kristina Killgrove, Ryan B. Anderson Jun 2013

Savage Minds Interview: Kristina Killgrove, Ryan B. Anderson

Faculty Publications

Kristina Killgrove is a biological anthropologist at the University of West Florida. Her research focuses on theorizing migration in antiquity and on understanding urban development and collapse through the analysis of human skeletal remains. She works primarily in the classical world, attempting to learn about the daily lives of the lower classes in Imperial Rome through osteological and biochemical analyses, but she has also worked on questions of population interaction in the contact-period southeastern U.S.and in Medieval Germany. A strong commitment to interdisciplinary research and teaching help her bridge the sometimes large divide between classics and anthropology.For more about Killgrove's …

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Determining The Depth Of Insertion Of Dynamically Invisible Membrane Peptides By Gel-Phase 1H Spin Diffusion Heteronuclear Correlation Nmr, T. Wang, H. Yao, M. Hong Jun 2013

Determining The Depth Of Insertion Of Dynamically Invisible Membrane Peptides By Gel-Phase 1H Spin Diffusion Heteronuclear Correlation Nmr, T. Wang, H. Yao, M. Hong

Faculty Publications

Solid-state NMR determination of the depth of insertion of membrane peptides and proteins has so far utilized 1H spin diffusion and paramagnetic relaxation enhancement experiments, which are typically conducted in the liquid-crystalline phase of the lipid bilayer. For membrane proteins or peptide assemblies that undergo intermediate-timescale motion in the liquid-crystalline membrane, these approaches are no longer applicable because the protein signals are broadened beyond detection. Here we show that the rigid-solid HETCOR experiment, with an additional spin diffusion period, can be used to determine the depth of proteins in gel-phase lipid membranes, where the proteins are immobilized to give high-intensity …

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Minimizing Human Infection From Escherichia Coli O157:H7 Using Gumbos, Marsha R. Cole, Min Li, Ravirajsinh Jadeja, Bilal El-Zahab, Daniel Hayes, Jeffery A. Hobden, Marlene E. Janes, Isiah M. Warner Jun 2013

Minimizing Human Infection From Escherichia Coli O157:H7 Using Gumbos, Marsha R. Cole, Min Li, Ravirajsinh Jadeja, Bilal El-Zahab, Daniel Hayes, Jeffery A. Hobden, Marlene E. Janes, Isiah M. Warner

Faculty Publications

Objectives: Reduction in faecal shedding of Shiga toxin-producing enterohaemorrhagic Escherichia coli (EHEC) in food-producing animals is a viable strategy to minimize human disease initiated by exposure to these microorganisms. To this end, an intervention strategy involving the electrostatic hybridization of two commonly used anti-infective agents for veterinary practice (i.e. chlorhexidine and ampicillin) was evaluated to curtail EHECtransmitted disease from ruminant sources. Chlorhexidine di-ampicillin is a novel group of uniform material based on organic salts (GUMBOS) with inherent in vitro antibacterial activity that comes from its parent antimicrobial ions, chlorhexidine and ampicillin. Methods: Antibacterial activities for chlorhexidine diacetate, sodium ampicillin, chlorhexidine …

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Trade-Offs, Geography, And Limits To Thermal Adaptation In A Tide Pool Copepod, Morgan W. Kelly, Richard K. Grosberg, Eric Sanford Jun 2013

Trade-Offs, Geography, And Limits To Thermal Adaptation In A Tide Pool Copepod, Morgan W. Kelly, Richard K. Grosberg, Eric Sanford

Faculty Publications

Antagonistic correlations among traits may slow the rate of adaptation to a changing environment. The tide pool copepod Tigriopus californicus is locally adapted to temperature, but within populations, the response to selection for increased heat tolerance plateaus rapidly, suggesting either limited variation within populations or costs of increased tolerance. To measure possible costs of thermal tolerance, we selected for increased upper lethal limits for 10 generations in 22 lines of T. californicus from six populations. Then, for each line, we measured six fitness-related traits. Selected lines showed an overall increase in male and female body sizes, fecundity, and starvation resistance, …

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Efindsite: Improved Prediction Of Ligand Binding Sites In Protein Models Using Meta-Threading, Machine Learning And Auxiliary Ligands, Michal Brylinski, Wei P. Feinstein Jun 2013

Efindsite: Improved Prediction Of Ligand Binding Sites In Protein Models Using Meta-Threading, Machine Learning And Auxiliary Ligands, Michal Brylinski, Wei P. Feinstein

Faculty Publications

Molecular structures and functions of the majority of proteins across different species are yet to be identified. Much needed functional annotation of these gene products often benefits from the knowledge of protein-ligand interactions. Towards this goal, we developed eFindSite, an improved version of FINDSITE, designed to more efficiently identify ligand binding sites and residues using only weakly homologous templates. It employs a collection of effective algorithms, including highly sensitive meta-threading approaches, improved clustering techniques, advanced machine learning methods and reliable confidence estimation systems. Depending on the quality of target protein structures, eFindSite outperforms geometric pocket detection algorithms by 15-40 % …

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Cotton Aphid (Heteroptera: Aphididae) Susceptibility To Commercial And Experimental Insecticides In The Southern United States, J. Gore, D. Cook, A. Catchot, B. R. Leonard, S. D. Stewart, G. Lorenz, D. Kerns Jun 2013

Cotton Aphid (Heteroptera: Aphididae) Susceptibility To Commercial And Experimental Insecticides In The Southern United States, J. Gore, D. Cook, A. Catchot, B. R. Leonard, S. D. Stewart, G. Lorenz, D. Kerns

Faculty Publications

Cotton aphid, Aphis gossypii Glover, has a history of developing resistance to novel insecticides. A program is needed to monitor cotton aphid susceptibility to new insecticides. Concentration-mortality bioassays were conducted from 2008 to 2011 to monitor the susceptibility of cotton aphids from fields across the midsouthern United States to thiamethoxam and sulfoxaflor. Flonicamid was included in 2010 and 2011. Bioassays followed the procedures described by the Insecticide Resistance Action Committee for testing neonicotinoids against cotton aphid. Mortality was rated at 48 and 72 h. These bioassays suggest that high levels of resistance to thiamethoxam occur in cotton aphid throughout the …

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A Meta-Analysis Identifies New Loci Associated With Body Mass Index In Individuals Of African Ancestry, Keri L. Monda, Gary K. Chen, Kira C. Taylor, Cameron Palmer, Todd L. Edwards, Leslie A. Lange, Maggie C.Y. Ng, Adebowale A. Adeyemo, Matthew A. Allison, Lawrence F. Bielak, Guanjie Chen, Mariaelisa Graff, Marguerite R. Irvin, Suhn K. Rhie, Guo Li, Yongmei Liu, Youfang Liu, Yingchang Lu, Michael A. Nalls, Yan V. Sun, Mary K. Wojczynski, Lisa R. Yanek, Melinda C. Aldrich, Adeyinka Ademola, Christopher I. Amos, Elisa V. Bandera, Cathryn H. Bock, Angela Britton, Ulrich Broeckel, Quiyin Cai, Neil E. Caporaso, Chris S. Carlson, John Carpten Jun 2013

A Meta-Analysis Identifies New Loci Associated With Body Mass Index In Individuals Of African Ancestry, Keri L. Monda, Gary K. Chen, Kira C. Taylor, Cameron Palmer, Todd L. Edwards, Leslie A. Lange, Maggie C.Y. Ng, Adebowale A. Adeyemo, Matthew A. Allison, Lawrence F. Bielak, Guanjie Chen, Mariaelisa Graff, Marguerite R. Irvin, Suhn K. Rhie, Guo Li, Yongmei Liu, Youfang Liu, Yingchang Lu, Michael A. Nalls, Yan V. Sun, Mary K. Wojczynski, Lisa R. Yanek, Melinda C. Aldrich, Adeyinka Ademola, Christopher I. Amos, Elisa V. Bandera, Cathryn H. Bock, Angela Britton, Ulrich Broeckel, Quiyin Cai, Neil E. Caporaso, Chris S. Carlson, John Carpten

Faculty Publications

Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the association of >3.2 million SNPs with BMI in 39,144 men and women of African ancestry and followed up the most significant associations in an additional 32,268 individuals of African ancestry. We identified one new locus at 5q33 (GALNT10, rs7708584, P = 3.4 × 10-11) and another at 7p15 when we included data from the GIANT consortium (MIR148A-NFE2L3, rs10261878, P = 1.2 × 10-10). We also found suggestive evidence of an association at a …

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Developing Models Of Disease Transmission: Insights From Ecological Studies Of Insects And Their Baculoviruses, Bret D. Elderd Jun 2013

Developing Models Of Disease Transmission: Insights From Ecological Studies Of Insects And Their Baculoviruses, Bret D. Elderd

Faculty Publications

No abstract provided.

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Rna Interference-Mediated Depletion Of N-Ethylmaleimide Sensitive Fusion Protein And Synaptosomal Associated Protein Of 25 Kda Results In The Inhibition Of Blood Feeding Of The Gulf Coast Tick, Amblyomma Maculatum, Rebecca Browning, Shahid Karim Jun 2013

Rna Interference-Mediated Depletion Of N-Ethylmaleimide Sensitive Fusion Protein And Synaptosomal Associated Protein Of 25 Kda Results In The Inhibition Of Blood Feeding Of The Gulf Coast Tick, Amblyomma Maculatum, Rebecca Browning, Shahid Karim

Faculty Publications

The signalling pathways in tick salivary glands that control ‘sialo‐secretome’ secretion at the tick−host interface remain elusive; however, this complex process is essential for successful feeding and manipulation of the host haemostatic response. Exocytosis of the sialo‐secretome in the salivary glands requires a core of soluble N‐ethylmaleimide‐sensitive fusion (NSF) attachment proteins (SNAPs) and receptor proteins (SNAREs). SNAREs have been identified as the key components in regulating the sialo‐secretome in the salivary gland cells. In this study, we utilized RNA interference to investigate the functional role of two Amblyomma maculatum SNARE complex proteins, AmNSF and AmSNAP‐25, in the tick salivary glands …

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The Musical Ear: Oral Tradition In The Usa, Chris Goertzen Jun 2013

The Musical Ear: Oral Tradition In The Usa, Chris Goertzen

Faculty Publications

No abstract provided.

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Exceed: Excellence In Your Engineering Education Summer Transition Program, Stacy Gleixner, Katherine Casey, Jared Tuberty, S. Latic, Patricia Backer, Emily Allen Jun 2013

Exceed: Excellence In Your Engineering Education Summer Transition Program, Stacy Gleixner, Katherine Casey, Jared Tuberty, S. Latic, Patricia Backer, Emily Allen

Faculty Publications

EXCEED: Excellence in Your Engineering Education is a ten day, residential summer transition program that was designed to improve retention and graduation rates at San José State University (SJSU). SJSU is a large, public institution in the West with a very diverse student population. However, the university has lower graduation and retention rates for certain student populations in engineering including underrepresented groups and first generation college students. This transition program was designed to meet five outcomes: acculturate the students to the College of Engineering and the university, enhance math and writing preparation, build community amongst the cohort of students, enhance …

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Mouse Embryonic Stem Cells Are Deficient In Type I Interferon Expression In Response To Viral Infections And Double-Stranded Rna, Ruoxing Wang, Jundi Wang, Amber M. Paul, Dhiraj Acharya, Fengwei Bai, Faqing Huang, Yan-Lin Guo May 2013

Mouse Embryonic Stem Cells Are Deficient In Type I Interferon Expression In Response To Viral Infections And Double-Stranded Rna, Ruoxing Wang, Jundi Wang, Amber M. Paul, Dhiraj Acharya, Fengwei Bai, Faqing Huang, Yan-Lin Guo

Faculty Publications

Embryonic stem cells (ESCs) are considered to be a promising cell source for regenerative medicine because of their unlimited capacity for self-renewal and differentiation. However, little is known about the innate immunity in ESCs and ESC-derived cells. We investigated the responses of mESCs to three types of live viruses; La Crosse virus (LACV), West Nile virus (WNV), and Sendai virus (SeV). Our results demonstrated mESCs were susceptible to viral infection, but they were unable to express type I interferons (IFNα and IFNβ,IFNα/β which differ from fibroblasts (10T1/2 cells) that robustly express IFNα/β upon viral infections. The failure of mESCs to …

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Dissemination Of Bloodmeal Acquired Rickettsia Felis In Cat Fleas, Ctenocephalides Felis, Chutima Thepparit, Supanee Hirunkanokpun, Vsevolod L. Popov, Lane D. Foil, Kevin R. Macaluso May 2013

Dissemination Of Bloodmeal Acquired Rickettsia Felis In Cat Fleas, Ctenocephalides Felis, Chutima Thepparit, Supanee Hirunkanokpun, Vsevolod L. Popov, Lane D. Foil, Kevin R. Macaluso

Faculty Publications

Background: Cat fleas, Ctenocephalides felis, are known biological vectors for Rickettsia felis. Rickettsial transmission can be vertical via transovarial transmission within a flea population, as well as horizontal between fleas through a bloodmeal. The previously undescribed infection kinetics of bloodmeal-acquired R. felis in cat fleas provides insight into the R. felis-flea interaction. Findings. In the present study, dissemination of R. felis in previously uninfected cat fleas fed an R. felis-infected bloodmeal was investigated. At weekly intervals for 28 days, rickettsial propagation, accumulation, and dissemination in gut epithelial cells, specifically in the hindgut and the specialized cells in the neck region …

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The Effects Of Practice On The Concurrent Performance Of A Speech And Postural Task In Persons With Parkinson Disease And Healthy Controls, K. Bo Foreman, Stuart Sondrup, Christopher Dromey, Eon Jarvis, Shawn Nissen, Leland E. Dibble May 2013

The Effects Of Practice On The Concurrent Performance Of A Speech And Postural Task In Persons With Parkinson Disease And Healthy Controls, K. Bo Foreman, Stuart Sondrup, Christopher Dromey, Eon Jarvis, Shawn Nissen, Leland E. Dibble

Faculty Publications

Purpose. Persons with Parkinson disease (PD) demonstrate deficits in motor learning as well as bidirectional interference (the performance of one task concurrently interferes with the performance of another task) during dual-task performance. Few studies have examined the practice dosages necessary for behavioral change in rehabilitation relevant tasks. Therefore, to compare the effects of age and PD on motor learning during dual-task performance, this pilot study examined persons with PD as well as neurologically healthy participants during concurrent performance of postural and speaking tasks. Methods. Seven persons with PD and 7 healthy age-matched and 10 healthy young control subjects …

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The Predicted Relative Risk Of Premature Ovarian Failure For Three Radiotherapy Modalities In A Girl Receiving Craniospinal Irradiation, A. Pérez-Andújar, W. D. Newhauser, P. J. Taddei, A. Mahajan, R. M. Howell May 2013

The Predicted Relative Risk Of Premature Ovarian Failure For Three Radiotherapy Modalities In A Girl Receiving Craniospinal Irradiation, A. Pérez-Andújar, W. D. Newhauser, P. J. Taddei, A. Mahajan, R. M. Howell

Faculty Publications

In girls and young women, irradiation of the ovaries can reduce the number of viable ovarian primordial follicles, which may lead to premature ovarian failure (POF) and subsequently to sterility. One strategy to minimize this late effect is to reduce the radiation dose to the ovaries. A primary means of reducing dose is to choose a radiotherapy technique that avoids irradiating nearby normal tissue; however, the relative risk of POF (RRPOF) due to the various therapeutic options has not been assessed. This study compared the predicted RRPOF after craniospinal proton radiotherapy, conventional photon radiotherapy (CRT) and intensity-modulated photon radiotherapy (IMRT). …

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Multitissue Molecular, Genomic, And Developmental Effects Of The Deepwater Horizon Oil Spill On Resident Gulf Killifish (Fundulus Grandis), Benjamin Dubansky, Andrew Whitehead, Jeffrey T. Miller, Charles D. Rice, Fernando Galvez May 2013

Multitissue Molecular, Genomic, And Developmental Effects Of The Deepwater Horizon Oil Spill On Resident Gulf Killifish (Fundulus Grandis), Benjamin Dubansky, Andrew Whitehead, Jeffrey T. Miller, Charles D. Rice, Fernando Galvez

Faculty Publications

The Deepwater Horizon oil rig disaster resulted in crude oil contamination along the Gulf coast in sensitive estuaries. Toxicity from exposure to crude oil can affect populations of fish that live or breed in oiled habitats as seen following the Exxon Valdez oil spill. In an ongoing study of the effects of Deepwater Horizon crude oil on fish, Gulf killifish (Fundulus grandis) were collected from an oiled site (Grande Terre, LA) and two reference locations (coastal MS and AL) and monitored for measures of exposure to crude oil. Killifish collected from Grande Terre had divergent gene expression in the liver …

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History Of Nutrient Inputs To The Northeastern United States, 1930–2000, Rebecca L. Hale, Joseph H. Hoover, Wilfred M. Wollheim, Charles J. Vorosmarty May 2013

History Of Nutrient Inputs To The Northeastern United States, 1930–2000, Rebecca L. Hale, Joseph H. Hoover, Wilfred M. Wollheim, Charles J. Vorosmarty

Faculty Publications

Humans have dramatically altered nutrient cycles at local to global scales. We examined changes in anthropogenic nutrient inputs to the northeastern United States (NE) from 1930 to 2000. We created a comprehensive time series of anthropogenic N and P inputs to 437 counties in the NE at 5 year intervals. Inputs included atmospheric N deposition, biological N2 fixation, fertilizer, detergent P, livestock feed, and human food. Exports included exports of feed and food and volatilization of ammonia. N inputs to the NE increased throughout the study period, primarily due to increases in atmospheric deposition and fertilizer. P inputs increased until …

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C-Terminal Low-Complexity Sequence Repeats Of Mycobacterium Smegmatis Ku Modulate Dna Binding, Ambuj K. Kushwaha, Anne Grove May 2013

C-Terminal Low-Complexity Sequence Repeats Of Mycobacterium Smegmatis Ku Modulate Dna Binding, Ambuj K. Kushwaha, Anne Grove

Faculty Publications

Ku protein is an integral component of the NHEJ (non-homologous end-joining) pathway of DSB (double-strand break) repair. Both eukaryotic and prokaryotic Ku homologues have been characterized and shown to bind DNA ends. A unique feature of Mycobacterium smegmatis Ku is its basic C-terminal tail that contains several lysine-rich low-complexity PAKKA repeats that are absent from homologues encoded by obligate parasitic mycobacteria. Such PAKKA repeats are also characteristic of mycobacterial Hlp (histone-like protein) for which they have been shown to confer the ability to appose DNA ends. Unexpectedly, removal of the lysine-rich extension enhances DNA-binding affinity, but an interaction between DNA …

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The Relationship Between Domestic And International Environmental Law, Tseming Yang May 2013

The Relationship Between Domestic And International Environmental Law, Tseming Yang

Faculty Publications

The connections between domestic and international law have proliferated in the last few decades as a directed result of the explosive growth of environmental treaties and other developments. Yet, most U.S. environmental lawyers remain relatively unaware even though these connections are increasingly affecting the practice of environmental law itself. Other parts of the book provide background on the specific substantive content of global environmental laws, both international as well as the environmental law systems of other countries. This chapter will address the relationship between the international and the domestic system, primarily the US. It will address three related question: 1) …

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Pre-Immunization With An Intramuscular Injection Of Aav9-Human Erythropoietin Vectors Reduces The Vector-Mediated Transduction Following Re-Administration In Rat Brain, Chun Yang, Wei Hua Yang, Sha Sha Chen, Bao Feng Ma, Bin Li, Tao Lu, Ting Yu Qu, Ronald L. Klein, Li Ru Zhao, Wei Ming Duan May 2013

Pre-Immunization With An Intramuscular Injection Of Aav9-Human Erythropoietin Vectors Reduces The Vector-Mediated Transduction Following Re-Administration In Rat Brain, Chun Yang, Wei Hua Yang, Sha Sha Chen, Bao Feng Ma, Bin Li, Tao Lu, Ting Yu Qu, Ronald L. Klein, Li Ru Zhao, Wei Ming Duan

Faculty Publications

We have recently demonstrated that adeno-associated virus serotype 9 (AAV9)-mediated human erythropoietin (hEPO) gene delivery into the brain protects dopaminergic (DA) neurons in the substantia nigra in a rat model of Parkinson's disease. In the present study, we examined whether pre-exposure to AAV9-hEPO vectors with an intramuscular or intrastriatal injection would reduce AAV9-mediated hEPO transduction in rat brain. We first characterized transgene expression and immune responses against AAV9-hEPO vectors in rat striatum at 4 days, 3 weeks and 6 months, and with doses ranging from 1011 to 1013 viral genomes. To sensitize immune system, rats received an injection of AAV9-hEPO …

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Lead Uptake In Diverse Plant Families: A Study Applying X-Ray Absorption Near Edge Spectroscopy, Gudrun L. Bovenkamp, Alexander Prange, Wolfgang Schumacher, Kyungmin Ham, Aaron P. Smith, Josef Hormes May 2013

Lead Uptake In Diverse Plant Families: A Study Applying X-Ray Absorption Near Edge Spectroscopy, Gudrun L. Bovenkamp, Alexander Prange, Wolfgang Schumacher, Kyungmin Ham, Aaron P. Smith, Josef Hormes

Faculty Publications

The chemical environment of lead in roots and leaves of plants from four different plant families and a lichen from a former lead mining site in the Eifel Mountains in Germany was determined by Pb L3-edge XANES measurements using solid reference compounds and also aqueous solutions of different ionic strength simulating the plant environment. Pb2+ ions in the plants were found to have two major coordinations, one with nine oxygen atoms in the first coordination shell similar to outer-sphere complexation and a second coordination with just three oxygen atoms similar to inner-sphere complexation. This can be interpreted assuming that lead …

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Testing The Role Of Meander Cutoff In Promoting Gene Flow Across A Riverine Barrier In Ground Skinks (Scincella Lateralis), Nathan D. Jackson, Christopher C. Austin May 2013

Testing The Role Of Meander Cutoff In Promoting Gene Flow Across A Riverine Barrier In Ground Skinks (Scincella Lateralis), Nathan D. Jackson, Christopher C. Austin

Faculty Publications

Despite considerable attention, the long-term impact of rivers on species diversification remains uncertain. Meander loop cutoff (MLC) is one river phenomenon that may compromise a river's diversifying effects by passively transferring organisms from one side of the river to the other. However, the ability of MLC to promote gene flow across rivers has not been demonstrated empirically. Here, we test several predictions of MLC-mediated gene flow in populations of North American ground skinks (Scincella lateralis) separated by a well-established riverine barrier, the Mississippi River: 1) individuals collected from within meander cutoffs should be more closely related to individuals across the …

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Performance Verification For Behavior-Based Robot Missions, Damian M. Lyons, Ronald Arkin, Shu Jiang, Tsung-Ming Liu, Paramesh Nirmal, J. Deeb May 2013

Performance Verification For Behavior-Based Robot Missions, Damian M. Lyons, Ronald Arkin, Shu Jiang, Tsung-Ming Liu, Paramesh Nirmal, J. Deeb

Faculty Publications

Certain robot missions need to perform predictably in a physical en-vironment that may only be poorly characterized in advance. This requirement raises many issues for existing approaches to software verification. An approach based on behavior-based controllers in a process-algebra framework is proposed by Lyons et al [15] to side-step state combinatorics. In this paper we show that this approach can be used to generate a Dynamic Bayesian Network for the problem, and that verification is reduced to a filtering problem for this network. We present validation results for the verification of a multiple waypoint robot mission using this approach.

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A Springtime Source Of Toxic Pseudo-Nitzschia Cells On Razor Clam Beaches In The Pacific Northwest, Barbara Hickey, Vera Trainer, P. Kosro, Nicolaus Adams, Thomas Connolly, Nancy Kachel, Susan Geier May 2013

A Springtime Source Of Toxic Pseudo-Nitzschia Cells On Razor Clam Beaches In The Pacific Northwest, Barbara Hickey, Vera Trainer, P. Kosro, Nicolaus Adams, Thomas Connolly, Nancy Kachel, Susan Geier

Faculty Publications

Concentrations of domoic acid (DA) above the regulatory limit in Washington coast razor clams are usually higher on northern beaches from summer to fall. Recent field studies have confirmed that the primary source of toxic Pseudo-nitzschia (PN) cells in those seasons is a semi-retentive topographically trapped seasonal eddy located offshore and north of the clamming beaches. Another semi-retentive coastal feature, Heceta Bank, that has been shown to support toxic PN cells in summer, is located south of Washington’s clamming beaches. In this paper we present evidence to demonstrate that Heceta Bank, although not a likely source of toxic cells to …

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Measure For Measure And The Discourse Of Husbandry, Benjamin Bertram Phd May 2013

Measure For Measure And The Discourse Of Husbandry, Benjamin Bertram Phd

Faculty Publications

The article explores early modern husbandry, which are more focused on encouraging its readers to lead pious, productive and economical lives. In "Measure for Measure," by William Shakespeare, the play centers on the rise of state husbandry as it focused on the parallels between Duke Vincentio and James I and views of sex and marriage. According to the author, there are two competing views of sex in the work including Lucio's pleasurable economy that resists the order of state husbandry.

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Changes In Plasma Melanocyte-Stimulating Hormone, Acth, Prolactin, Gh, Lh, Fsh, And Thyroid-Stimulating Hormone In Response To Injection Of Sulpiride, Thyrotropin-Releasing Hormone, Or Vehicle In Insulin-Sensitive And -Insensitive Mares, N. Arana Valencia, D. L. Thompson, P. B. Mitcham May 2013

Changes In Plasma Melanocyte-Stimulating Hormone, Acth, Prolactin, Gh, Lh, Fsh, And Thyroid-Stimulating Hormone In Response To Injection Of Sulpiride, Thyrotropin-Releasing Hormone, Or Vehicle In Insulin-Sensitive And -Insensitive Mares, N. Arana Valencia, D. L. Thompson, P. B. Mitcham

Faculty Publications

Six insulin-sensitive and 6 insulin-insensitive mares were used in a replicated 3 by 3 Latin square design to determine the pituitary hormonal responses (compared with vehicle) to sulpiride and thyrotropin-releasing hormone (TRH), 2 compounds commonly used to diagnose pituitary pars intermedia dysfunction (PPID) in horses. Mares were classified as insulin sensitive or insensitive by their previous glucose responses to direct injection of human recombinant insulin. Treatment days were February 25, 2012, and March 10 and 24, 2012. Treatments were sulpiride (racemic mixture, 0.01 mg/kg BW), TRH (0.002 mg/kg BW), and vehicle (saline, 0.01 mL/kg BW) administered intravenously. Blood samples were …

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