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Ronald P. Kiene: Major League Pitching Prospect, Avid Sports Fisherman, And Biogeochemist Who Probed The Mysteries Of The Oceanic Organosulfur Cycle, Ronald S. Oremland, Gary King, Pieter Visscher, Douglas G. Capone Nov 2019

Ronald P. Kiene: Major League Pitching Prospect, Avid Sports Fisherman, And Biogeochemist Who Probed The Mysteries Of The Oceanic Organosulfur Cycle, Ronald S. Oremland, Gary King, Pieter Visscher, Douglas G. Capone

Faculty Publications

No abstract provided.

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Testing Predictability Of Disease Outbreaks With A Simple Model Of Pathogen Biogeography, Tad A. Dallas, Colin J. Carlson, Timothée Poisot Nov 2019

Testing Predictability Of Disease Outbreaks With A Simple Model Of Pathogen Biogeography, Tad A. Dallas, Colin J. Carlson, Timothée Poisot

Faculty Publications

© 2019 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. Predicting disease emergence and outbreak events is a critical task for public health professionals and epidemiologists. Advances in global disease surveillance are increasingly generating datasets that are worth more than their component parts for prediction-oriented work. Here, we use a trait-free approach which leverages information on the global community of human infectious diseases to predict the biogeography of pathogens through time. Our approach takes pairwise dissimilarities between countries’ pathogen …

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Binding Site Matching In Rational Drug Design: Algorithms And Applications, Misagh Naderi, Jeffrey Mitchell Lemoine, Rajiv Gandhi Govindaraj, Omar Zade Kana, Wei Pan Feinstein, Michal Brylinski Nov 2019

Binding Site Matching In Rational Drug Design: Algorithms And Applications, Misagh Naderi, Jeffrey Mitchell Lemoine, Rajiv Gandhi Govindaraj, Omar Zade Kana, Wei Pan Feinstein, Michal Brylinski

Faculty Publications

© 2018 The Author(s) 2018. Published by Oxford University Press. All rights reserved. Interactions between proteins and small molecules are critical for biological functions. These interactions often occur in small cavities within protein structures, known as ligand-binding pockets. Understanding the physicochemical qualities of binding pockets is essential to improve not only our basic knowledge of biological systems, but also drug development procedures. In order to quantify similarities among pockets in terms of their geometries and chemical properties, either bound ligands can be compared to one another or binding sites can be matched directly. Both perspectives routinely take advantage of computational …

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A Bayesian Adaptive Phase Ii Clinical Trial Design Accounting For Spatial Variation, Beibei Guo, Yong Zang Nov 2019

A Bayesian Adaptive Phase Ii Clinical Trial Design Accounting For Spatial Variation, Beibei Guo, Yong Zang

Faculty Publications

Conventional phase II clinical trials evaluate the treatment effects under the assumption of patient homogeneity. However, due to inter-patient heterogeneity, the effect of a treatment may differ remarkably among subgroups of patients. Besides patient’s individual characteristics such as age, gender, and biomarker status, a substantial amount of this heterogeneity could be due to the spatial variation across geographic regions because of unmeasured or unknown spatially varying environmental and social exposures. In this article, we propose a hierarchical Bayesian adaptive design for two-arm randomized phase II clinical trials that accounts for the spatial variation as well as patient’s individual characteristics. We …

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Emergent Functional Behaviour Of Humic Substances Perceived As Complex Labile Aggregates Of Small Organic Molecules And Oligomers, Robert L. Cook Nov 2019

Emergent Functional Behaviour Of Humic Substances Perceived As Complex Labile Aggregates Of Small Organic Molecules And Oligomers, Robert L. Cook

Faculty Publications

The structural organisation of humic substances (HS) has been a central question of earth sciences for several decades. The latest experimental results have led to the recognition of HS as complex mixtures of small molecules and oligomers. We investigate the correlation between the chemical composition of HS, perceived as labile aggregates, and the emergent functions. Computational modelling was used to help to understand the processes and mechanisms on the molecular scale that occur in different fractions of the HS, fulvic acids (FA) and humic acids (HA), as they interact with metal ions and organic pollutants. The importance of non-covalent interactions …

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Avian Ecological Succession In The Amazon: A Long-Term Case Study Following Experimental Deforestation, Cameron L. Rutt, Vitek Jirinec Nov 2019

Avian Ecological Succession In The Amazon: A Long-Term Case Study Following Experimental Deforestation, Cameron L. Rutt, Vitek Jirinec

Faculty Publications

Approximately 20% of the Brazilian Amazon has now been deforested, and the Amazon is currently experiencing the highest rates of deforestation in a decade, leading to large-scale land-use changes. Roads have consistently been implicated as drivers of ongoing Amazon deforestation and may act as corridors to facilitate species invasions. Long-term data, however, are necessary to determine how ecological succession alters avian communities following deforestation and whether established roads lead to a constant influx of new species. We used data across nearly 40 years from a large-scale deforestation experiment in the central Amazon to examine the avian colonization process in a …

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Effect Of F1 And F2 Generations On Genetic Variability And Working Steps Of Doubled Haploid Production In Maize, Evellyn Giselly De Oliveira Couto, Mayara Neves Cury, Massaine Bandeira E Souza, Ítalo Stefanine Correia Granato, Miriam Suzane Vidotti, Deoclécio Domingos Garbuglio, José Crossa, Juan Burgueño, Roberto Fritsche-Neto Nov 2019

Effect Of F1 And F2 Generations On Genetic Variability And Working Steps Of Doubled Haploid Production In Maize, Evellyn Giselly De Oliveira Couto, Mayara Neves Cury, Massaine Bandeira E Souza, Ítalo Stefanine Correia Granato, Miriam Suzane Vidotti, Deoclécio Domingos Garbuglio, José Crossa, Juan Burgueño, Roberto Fritsche-Neto

Faculty Publications

For doubled haploid (DH) production in maize, F1 generation has been the most frequently used for haploid induction due to facility in the process. However, using F2 generation would be a good alternative to increase genetic variability owing to the additional recombination in meiosis. Our goals were to compare the effect of F1 and F2 generations on DH production in tropical germplasm, evaluating the R1-navajo expression in seeds, the working steps of the methodology, and the genetic variability of the DH lines obtained. Sources germplasm in F1 and F2 generations were crossed with the tropicalized haploid inducer LI-ESALQ. After harvest, …

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The Empower Action Model: A Framework For Preventing Adverse Childhood Experiences By Promoting Health, Equity, And Well-Being Across The Life Span, Aditi Srivastav, Melissa Strompolis, Amy Moseley, Kelsay Shania Daniels Nov 2019

The Empower Action Model: A Framework For Preventing Adverse Childhood Experiences By Promoting Health, Equity, And Well-Being Across The Life Span, Aditi Srivastav, Melissa Strompolis, Amy Moseley, Kelsay Shania Daniels

Faculty Publications

The empower action model addresses childhood adversity as a root cause of disease by building resilience across multiple levels of influence to promote health, equity, and well-being. The model builds on the current evidence around adverse childhood experiences and merges important frameworks within key areas of public health—the socio-ecological model, protective factors, race equity and inclusion, and the life course perspective. The socio-ecological model is used as the foundation for this model to highlight the multilevel approach needed for improvement in public health. Five key principles that build on the protective factors literature are developed to be applied at each …

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Changes In Southeastern Usa Summer Precipitation Event Types Using Instrumental (1940-2018) And Tree-Ring (1790-2018) Data, T.J. Mitchell, P.A. Knapp, T.W. Patterson Oct 2019

Changes In Southeastern Usa Summer Precipitation Event Types Using Instrumental (1940-2018) And Tree-Ring (1790-2018) Data, T.J. Mitchell, P.A. Knapp, T.W. Patterson

Faculty Publications

We examined short- and long-term changes in precipitation event types using instrumental (1940–2018) and tree-ring (1790–2018) data from North Carolina, USA. We documented the amount and frequency of summer (July–September) precipitation events using daily weather station data. Stationary front precipitation (SFP) represented 71% of total summer rainfall and SFP and convective uplift combined (i.e., quasi-stationary precipitation, QSP) represented 87%. SFP (r = 0.52, p < 0.01) and QSP (r = 0.61, p < 0.01) precipitation reconstructions from a montane longleaf pine latewood chronology both recorded significant declines during 1940–2018, matching the instrumental record. Conversely, no significant change in either SFP or QSP occured during the full reconstruction indicating the instrumental decline was unmatched throughout 1790–1939. Our method demonstrates that variations in latewood growth can be attributed to specific precipitation event types and that the relative contribution of each event type can be quantified over a multi-century period.

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Repeated Vaginal Exposures To The Common Cosmetic And Household Preservative Methylisothiazolinone Induce Persistent, Mast Cell-Dependent Genital Pain In Nd4 Mice, Erica Arriaga-Gomez, Jacyln Kline, Elizabeth Emanuel, Nefeli Neamonitaki, Tenzin Yangdon, Hayley Zacheis, Dogukan Pasha, Jinyoung Lim, Susan Bush, Beebie Boo, Hanna Mengistu, Ruby Kinnamon, Robin Shields-Cutler, Wattenberg Wattenberg, Devavani Chatterjea Oct 2019

Repeated Vaginal Exposures To The Common Cosmetic And Household Preservative Methylisothiazolinone Induce Persistent, Mast Cell-Dependent Genital Pain In Nd4 Mice, Erica Arriaga-Gomez, Jacyln Kline, Elizabeth Emanuel, Nefeli Neamonitaki, Tenzin Yangdon, Hayley Zacheis, Dogukan Pasha, Jinyoung Lim, Susan Bush, Beebie Boo, Hanna Mengistu, Ruby Kinnamon, Robin Shields-Cutler, Wattenberg Wattenberg, Devavani Chatterjea

Faculty Publications

A history of allergies doubles the risk of vulvodynia-a chronic pain condition of unknown etiology often accompanied by increases in numbers of vulvar mast cells. We previously established the biological plausibility of this relationship in mouse models where repeated exposures to the allergens oxazolone or dinitrofluorobenzene on the labiar skin or inside the vaginal canal of ND4 Swiss Webster outbred mice led to persistent tactile sensitivity and local increases in mast cells. In these models, depletion of mast cells alleviated pain. While exposure to cleaning chemicals has been connected to elevated vulvodynia risk, no single agent has been linked to …

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Oyster Reefs In Northern Gulf Of Mexico Estuaries Harbor Diverse Fish And Decapod Crustacean Assemblages: A Meta-Synthesis, Megan K. La Peyre, Danielle Aguilar Marshall, Lindsay S. Miller Oct 2019

Oyster Reefs In Northern Gulf Of Mexico Estuaries Harbor Diverse Fish And Decapod Crustacean Assemblages: A Meta-Synthesis, Megan K. La Peyre, Danielle Aguilar Marshall, Lindsay S. Miller

Faculty Publications

Oyster reefs provide habitat for numerous fish and decapod crustacean species that mediate ecosystem functioning and support vibrant fisheries. Recent focus on the restoration of eastern oyster (Crassostrea virginica) reefs stems from this role as a critical ecosystem engineer. Within the shallow estuaries of the northern Gulf of Mexico (nGoM), the eastern oyster is the dominant reef building organism. This study synthesizes data on fish and decapod crustacean occupancy of oyster reefs across nGoM with the goal of providing management and restoration benchmarks, something that is currently lacking for the region. Relevant data from 23 studies were identified, representing data …

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Genomic Selection In Rubber Tree Breeding: A Comparison Of Models And Methods For Managing G×E Interactions, Livia M. Souza, Felipe R. Francisco, Paulo S. Gonçalves, Erivaldo J. Scaloppi Junior, Vincent Le Guen, Roberto Fritsche-Neto, Anete P. Souza Oct 2019

Genomic Selection In Rubber Tree Breeding: A Comparison Of Models And Methods For Managing G×E Interactions, Livia M. Souza, Felipe R. Francisco, Paulo S. Gonçalves, Erivaldo J. Scaloppi Junior, Vincent Le Guen, Roberto Fritsche-Neto, Anete P. Souza

Faculty Publications

Several genomic prediction models combining genotype × environment (G×E) interactions have recently been developed and used for genomic selection (GS) in plant breeding programs. G×E interactions reduce selection accuracy and limit genetic gains in plant breeding. Two data sets were used to compare the prediction abilities of multienvironment G×E genomic models and two kernel methods. Specifically, a linear kernel, or GB (genomic best linear unbiased predictor [GBLUP]), and a nonlinear kernel, or Gaussian kernel (GK), were used to compare the prediction accuracies (PAs) of four genomic prediction models: 1) a single-environment, main genotypic effect model (SM); 2) a multienvironment, main …

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Cross-Linked Poly(4-Vinylpyridine-N-Oxide) As A Polymer-Supported Oxygen Atom Transfer Reagent, Anna M. Bauer, Erin E. Ramey, Kjersti G. Oberle, Gretchen A. Fata, Chloe D. Hutchison, Christopher R. Turlington Oct 2019

Cross-Linked Poly(4-Vinylpyridine-N-Oxide) As A Polymer-Supported Oxygen Atom Transfer Reagent, Anna M. Bauer, Erin E. Ramey, Kjersti G. Oberle, Gretchen A. Fata, Chloe D. Hutchison, Christopher R. Turlington

Faculty Publications

Oxygen atom transfer (OAT) reagents are common in biological and industrial oxidation reactions. While many heterogeneous catalysts have been utilized in OAT reactions, heterogeneous OAT reagents have not been explored. Here, cross-linked poly(4-vinylpyridine-N-oxide), called x-PVP-N-oxide, was tested as a heterogeneous OAT reagent and its oxidation chemistry compared to its molecular counterpart, pyridine-N-oxide. The insoluble oxidant x-PVP-N-oxide demonstrated comparable reactivity to pyridine-N-oxide in direct oxidation reactions of phosphines and phosphites in acetonitrile, but x-PVP-N-oxide did not react in other solvents. The polymer backbone of x-PVP-N-oxide, however, allowed …

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Molecular Properties Are A Primary Control On The Microbial Utilization Of Dissolved Organic Matter In The Ocean, Yuan Shen, Ronald Benner Oct 2019

Molecular Properties Are A Primary Control On The Microbial Utilization Of Dissolved Organic Matter In The Ocean, Yuan Shen, Ronald Benner

Faculty Publications

The global ocean sequesters a large amount of reduced carbon in dissolved organic molecules that can persist for centuries to millennia. The persistence of dissolved organic carbon (DOC) in the deep ocean has been attributed to inherently refractory molecules and to low concentrations of molecules, but the relative roles of molecular properties and molecular concentrations remain uncertain. We investigate both of these possibilities using bioassay experiments with unfiltered seawater collected from five depths (50–1500 m) at the Bermuda Atlantic TimeSeries Study site. The microbial utilization of compositionally distinct forms of seawater DOC at in situ and elevated concentrations was determined. …

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Core–Shell Nanospheres Behind The Blue Eyes Of The Bay Scallop Argopecten Irradians, Olivia K. Harris, Alexandra C.N. Kingston, Caitlin S. Wolfe, Soumitra Ghoshroy, Sönke Johnsen, Daniel Isaac Speiser Oct 2019

Core–Shell Nanospheres Behind The Blue Eyes Of The Bay Scallop Argopecten Irradians, Olivia K. Harris, Alexandra C.N. Kingston, Caitlin S. Wolfe, Soumitra Ghoshroy, Sönke Johnsen, Daniel Isaac Speiser

Faculty Publications

The bay scallop Argopecten irradians (Mollusca: Bivalvia) has dozens of iridescent blue eyes that focus light using mirror-based optics. Here, we test the hypothesis that these eyes appear blue because of photonic nanostructures that preferentially scatter short-wavelength light. Using transmission electron microscopy, we found that the epithelial cells covering the eyes of A. irradians have three distinct layers: an outer layer of microvilli, a middle layer of random close-packed nanospheres and an inner layer of pigment granules. The nanospheres are approximately 180 nm in diameter and consist of electron-dense cores approximately 140 nm in diameter surrounded by less electron-dense shells …

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The Association Between Dietary Inflammatory Index (Dii) And Cancer Risk In Korea: A Prospective Cohort Study Within The Koges-Hexa Study, Injeong Ryu, Minji Kwon, Cheongmin Sohn, Nitin Shivappa, James R. Hébert, Woori Na, Mi Kyung Kim Oct 2019

The Association Between Dietary Inflammatory Index (Dii) And Cancer Risk In Korea: A Prospective Cohort Study Within The Koges-Hexa Study, Injeong Ryu, Minji Kwon, Cheongmin Sohn, Nitin Shivappa, James R. Hébert, Woori Na, Mi Kyung Kim

Faculty Publications

Several epidemiological studies have shown that there are consistently positive associations between dietary inflammatory index (DII (R)) scores and cancer incidence in Western populations. However, few DII-cancer studies have been conducted in East Asian populations. In a large cohort representative of the general Korean population, we investigated whether the DII is associated with overall cancer risk. A total of 163,660 participants (56,781 males and 106,879 females) had evaluable data for analyses. This follow-up study was carried out over the course of 7.9 years. DII scores were calculated based on Semi-Quantitative Food-Frequency Questionnaire (SQ-FFQ) data for 106 food items. Cancers were …

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Upcycling Single-Use Polyethylene Into High-Quality Liquid Products, Gokhan Celik, Robert M. Kennedy, Ryan A. Hackler, Magali Ferrandon, Akalanka Tennakoon, Smita Patnaik, Anne M. Lapointe, Salai Ammal, Andreas Heyden, Frédéric A. Perras, Marek Pruski, Susannah L. Scott, Kenneth R. Poeppelmeier, Aaron D. Sadow, Massimiliano Delferro Oct 2019

Upcycling Single-Use Polyethylene Into High-Quality Liquid Products, Gokhan Celik, Robert M. Kennedy, Ryan A. Hackler, Magali Ferrandon, Akalanka Tennakoon, Smita Patnaik, Anne M. Lapointe, Salai Ammal, Andreas Heyden, Frédéric A. Perras, Marek Pruski, Susannah L. Scott, Kenneth R. Poeppelmeier, Aaron D. Sadow, Massimiliano Delferro

Faculty Publications

Our civilization relies on synthetic polymers for all aspects of modern life; yet, inefficient recycling and extremely slow environmental degradation of plastics are causing increasing concern about their widespread use. After a single use, many of these materials are currently treated as waste, underutilizing their inherent chemical and energy value. In this study, energy-rich polyethylene (PE) macromolecules are catalytically transformed into value-added products by hydrogenolysis using well-dispersed Pt nanoparticles (NPs) supported on SrTiO3 perovskite nanocuboids by atomic layer deposition. Pt/SrTiO3 completely converts PE (Mn = 8000− 158,000 Da) or a single-use plastic bag (Mn = 31,000 Da) into high-quality liquid …

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Purification Of Tag-Free Chlamydia Trachomatis Scc4 For Structural Studies Using Sarkosyl-Assisted On-Column Complex Dissociation, Thilini O. Ukwaththage, Octavia Y. Goodwin, Abigael C. Songok, Alexa M. Tafaro, Li Shen, Megan A. Macnaughtan Oct 2019

Purification Of Tag-Free Chlamydia Trachomatis Scc4 For Structural Studies Using Sarkosyl-Assisted On-Column Complex Dissociation, Thilini O. Ukwaththage, Octavia Y. Goodwin, Abigael C. Songok, Alexa M. Tafaro, Li Shen, Megan A. Macnaughtan

Faculty Publications

Copyright © 2019 American Chemical Society. Chlamydia trachomatis is an obligate intracellular bacterial pathogen that causes the most common sexually transmitted bacterial disease in the world. The bacterium has a unique biphasic developmental cycle with a type III secretion system (T3SS) to invade host cells. Scc4 is a class I T3SS chaperone forming a heterodimer complex with Scc1 to chaperone the essential virulence effector, CopN. Scc4 also functions as an RNA polymerase binding protein to regulate σ66-dependent transcription. Aggregation and low solubility of 6X-histidine-tagged Scc4 and the insolubility of 6X-histidine and FLAG-tagged Scc1 expressed in Escherichia coli have hindered the …

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Superior Colliculus Lesions Lead To Disrupted Responses To Light In Diurnal Grass Rats (Arvicanthis Niloticus), Andrew J. Gall, Alyssa M. Goodwin, Ohanes S. Khacherian, Laura B. Teal Oct 2019

Superior Colliculus Lesions Lead To Disrupted Responses To Light In Diurnal Grass Rats (Arvicanthis Niloticus), Andrew J. Gall, Alyssa M. Goodwin, Ohanes S. Khacherian, Laura B. Teal

Faculty Publications

The circadian system regulates daily rhythms of physiology and behavior. Although extraordinary advances have been made to elucidate the brain mechanisms underlying the circadian system in nocturnal species, less is known in diurnal species. Recent studies have shown that retinorecipient brain areas such as the intergeniculate leaflet (IGL) and olivary pretectal nucleus (OPT) are critical for the display of normal patterns of daily activity in diurnal grass rats (Arvicanthis niloticus). Specifically, grass rats with IGL and OPT lesions respond to light in similar ways to intact nocturnal animals. Importantly, both the IGL and OPT project to one another …

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Circulating Obesity-Driven Biomarkers Are Associated With Risk Of Clear Cell Renal Cell Carcinoma: A Two-Stage, Case-Control Study, Qinchuan Wang, Huakang Tu, Meiling Zhu, Dong Liang, Yuanqing Ye, David W. Chang, Yin Long, Xifeng Wu Oct 2019

Circulating Obesity-Driven Biomarkers Are Associated With Risk Of Clear Cell Renal Cell Carcinoma: A Two-Stage, Case-Control Study, Qinchuan Wang, Huakang Tu, Meiling Zhu, Dong Liang, Yuanqing Ye, David W. Chang, Yin Long, Xifeng Wu

Faculty Publications

Obesity is one of modifiable risk factors for clear cell renal cell cancer (ccRCC). We aim to identify the association between obesity-driven biomarkers and ccRCC risk. This is a retrospective, two-phase, case-control study involving 682 cases and 733 controls. Obesity-driven biomarkers [gastric inhibitory polypeptide (GIP), C-peptide, insulin, resistin, adipsin, peptide YY, pancreatic polypeptide, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), plasminogen activator inhibitor-1, monocyte chemoattractant protein 1, lipocalin2, leptin, adiponectin] were measured using the Milliplex method. Multivariate logistic regression was used to assess the associations between biomarkers and ccRCC risk. Results revealed that GIP, C-peptide, IL-6 and TNF-α levels were consistently …

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Current Understanding Of West Nile Virus Clinical Manifestations, Immune Responses, Neuroinvasion, And Immunotherapeutic Implications, Fengwei Bai, E. Ashley Thompson, Parminder J.S. Vig, A. Arturo Leis Oct 2019

Current Understanding Of West Nile Virus Clinical Manifestations, Immune Responses, Neuroinvasion, And Immunotherapeutic Implications, Fengwei Bai, E. Ashley Thompson, Parminder J.S. Vig, A. Arturo Leis

Faculty Publications

West Nile virus (WNV) is the most common mosquito-borne virus in North America. WNV-associated neuroinvasive disease affects all ages, although elderly and immunocompromised individuals are particularly at risk. WNV neuroinvasive disease has killed over 2300 Americans since WNV entered into the United States in the New York City outbreak of 1999. Despite 20 years of intensive laboratory and clinical research, there are still no approved vaccines or antivirals available for human use. However, rapid progress has been made in both understanding the pathogenesis of WNV and treatment in clinical practices. This review summarizes our current understanding of WNV infection in …

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Short Term Effects Of Hurricane Irma And Cyanobacterial Blooms On Ammonium Cycling Along A Freshwater-Estuarine Continuum In South Florida, Justyna J. Hampel, Mark J. Mccarthy, Megan H. Reed, Silvia E. Newell Oct 2019

Short Term Effects Of Hurricane Irma And Cyanobacterial Blooms On Ammonium Cycling Along A Freshwater-Estuarine Continuum In South Florida, Justyna J. Hampel, Mark J. Mccarthy, Megan H. Reed, Silvia E. Newell

Faculty Publications

Lacustrine and coastal systems are vulnerable to the increasing number and intensity of tropical storms driven by climate change. Strong winds associated with tropical storms can mobilize nutrients in sediments and alter nitrogen and phosphorus cycling, leading to amplification of preexisting conditions, such as eutrophication and cyanobacterial blooms (cyanoHABs). In 2016, Florida declared a State of Emergency within and downstream of Lake Okeechobee (LO) due to toxic cyanobacterial blooms (primarily Microcystis). The blooms originated in LO, but flood control measures released water from LO to the brackish St. Lucie Estuary (SLE). In September 2017, Hurricane Irma traversed the Florida …

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Environmentally Persistent Free Radicals: Linking Air Pollution And Poor Respiratory Health?, Peter D. Sly, Stephania A. Cormier, Slawomir Lomnicki, Jeffrey N. Harding, Keith Grimwood, Griffith University Oct 2019

Environmentally Persistent Free Radicals: Linking Air Pollution And Poor Respiratory Health?, Peter D. Sly, Stephania A. Cormier, Slawomir Lomnicki, Jeffrey N. Harding, Keith Grimwood, Griffith University

Faculty Publications

No abstract provided.

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How Protein - Protein Interactions Contribute To Pyrenoid Formation In Chlamydomonas, Ananya Mukherjee, James V. Moroney Oct 2019

How Protein - Protein Interactions Contribute To Pyrenoid Formation In Chlamydomonas, Ananya Mukherjee, James V. Moroney

Faculty Publications

© The Author(s) 2019. The chloroplast pyrenoid, an important component of the CO2 concentrating mechanism of algae, is a structure composed primarily of Rubisco. In Chlamydomonas, Rubisco in the pyrenoid is held together by the linker protein EPYC1. Atkinson et al., (2019) determined the regions of the Rubisco small subunit and EPYC1 that are important for the protein-protein interaction, thus making progress towards reconstruction of a pyrenoid in higher plants. Why is a protein soluble in one organism while its homologue in another species becomes part of a liquidlike cell structure? That is the question being addressed by Atkinson et …

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Dysbiosis-Associated Enteric Glial Cell Immune-Activation And Redox Imbalance Modulate Tight Junction Protein Expression In Gulf War Illness Pathology, Diana Kimono, Sutapa Sarkar, Muayad Albadrani, Ratanesh K. Seth, Dipro Bose, Ayan Mondal, Yuxi Li, Amar N. Kar, Mitzi Nagarkatti, Prakash Nagarkatti, Kimberly Sullivan, Patricia Janulewicz, Stephen Lasley, Ronnie Horner, Nancy Klimas, Saurabh Chatterjee Oct 2019

Dysbiosis-Associated Enteric Glial Cell Immune-Activation And Redox Imbalance Modulate Tight Junction Protein Expression In Gulf War Illness Pathology, Diana Kimono, Sutapa Sarkar, Muayad Albadrani, Ratanesh K. Seth, Dipro Bose, Ayan Mondal, Yuxi Li, Amar N. Kar, Mitzi Nagarkatti, Prakash Nagarkatti, Kimberly Sullivan, Patricia Janulewicz, Stephen Lasley, Ronnie Horner, Nancy Klimas, Saurabh Chatterjee

Faculty Publications

About 14% of veterans who suffer from Gulf war illness (GWI) complain of some form of gastrointestinal disorder but with no significant markers of clinical pathology. Our previous studies have shown that exposure to GW chemicals resulted in altered microbiome which was associated with damage associated molecular pattern (DAMP) release followed by neuro and gastrointestinal inflammation with loss of gut barrier integrity. Enteric glial cells (EGC) are emerging as important regulators of the gastrointestinal tract and have been observed to change to a reactive phenotype in several functional gastrointestinal disorders such as IBS and IBD. This study is aimed at …

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Parasitic Microbiome Project: Grand Challenges, Nolwenn M. Dheilly, Joaquín Martínez Martínez, Karyna Rosario, Paul J. Brindley, Raina N. Fichorava, Jonathan Z. Kaye, Kevin D. Kohl, Laura J. Knoll, Julius Lukeš, Susan L. Perkins, Robert Poulin, Lynn Schriml, Luke R. Thompson Oct 2019

Parasitic Microbiome Project: Grand Challenges, Nolwenn M. Dheilly, Joaquín Martínez Martínez, Karyna Rosario, Paul J. Brindley, Raina N. Fichorava, Jonathan Z. Kaye, Kevin D. Kohl, Laura J. Knoll, Julius Lukeš, Susan L. Perkins, Robert Poulin, Lynn Schriml, Luke R. Thompson

Faculty Publications

No abstract provided.

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Ethylene And Phloem Signals Are Involved In The Regulation Of Responses To Fe And P Deficiencies In Roots Of Strategy I Plants, Carlos Lucena, Rafael Porras, María J. García, Esteban Alcántara, Rafael Pérez-Vicente, Ángel M. Zamarreño, Eva Bacaicoa, José M. García-Mina, Aaron P. Smith, Francisco J. Romera Oct 2019

Ethylene And Phloem Signals Are Involved In The Regulation Of Responses To Fe And P Deficiencies In Roots Of Strategy I Plants, Carlos Lucena, Rafael Porras, María J. García, Esteban Alcántara, Rafael Pérez-Vicente, Ángel M. Zamarreño, Eva Bacaicoa, José M. García-Mina, Aaron P. Smith, Francisco J. Romera

Faculty Publications

© Copyright © 2019 Lucena, Porras, García, Alcántara, Pérez-Vicente, Zamarreño, Bacaicoa, García-Mina, Smith and Romera. Iron (Fe) and phosphorus (P) are two essential mineral nutrients whose acquisition by plants presents important environmental and economic implications. Both elements are abundant in most soils but scarcely available to plants. To prevent Fe or P deficiency dicot plants initiate morphological and physiological responses in their roots aimed to specifically acquire these elements. The existence of common signals in Fe and P deficiency pathways suggests the signaling factors must act in conjunction with distinct nutrient-specific signals in order to confer tolerance to each deficiency. …

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Does Time Spent Using Social Media Impact Mental Health?: An Eight Year Longitudinal Study, Sarah M. Coyne, Adam A. Rogers, Jessica D. Zurcher, Laura Stockdale, Mccall Booth Oct 2019

Does Time Spent Using Social Media Impact Mental Health?: An Eight Year Longitudinal Study, Sarah M. Coyne, Adam A. Rogers, Jessica D. Zurcher, Laura Stockdale, Mccall Booth

Faculty Publications

Many studies have found a link between time spent using social media and mental health issues, such as depression and anxiety. However, the existing research is plagued by cross-sectional research and lacks analytic techniques examining individual change over time. The current research involves an 8-year longitudinal study examining the association between time spent using social media and depression and anxiety at the intra-individual level. Participants included 500 adolescents who completed once-yearly questionnaires between the ages of 13 and 20. Results revealed that increased time spent on social media was not associated with increased mental health issues across development when examined …

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Exploring Ways To Support Preservice Teachers' Use Of Udl In Planning And Instruction, K. Alisa Lowrey, Audra Classen, Anne Sylvest Oct 2019

Exploring Ways To Support Preservice Teachers' Use Of Udl In Planning And Instruction, K. Alisa Lowrey, Audra Classen, Anne Sylvest

Faculty Publications

There is limited research documenting current efforts to support preservice teachers to use the universal design for learning (UDL) framework in authentic teaching experiences. To increase knowledge on the effects of preparing preservice teachers to incorporate the UDL framework, researchers examined the effects a UDL professional development seminar that was delivered during the student teaching phase had on eight teacher candidates during their K–12 placement. Using a concurrent triangulation mixed-method design, researchers examined lesson plans, video footage of teaching, teacher candidate reflections on their teaching sample, and university supervisor measures of the same sample before and after the UDL seminar. …

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Accumulation Over Evolutionary Time As A Major Cause Of Biodiversity Hotspots In Conifers, Mekala Sundaram, Michael J. Donoghue, Aljos Farjon, Denis Filer, Sarah Mathews, Walter Jetz, Andrew B. Leslie Oct 2019

Accumulation Over Evolutionary Time As A Major Cause Of Biodiversity Hotspots In Conifers, Mekala Sundaram, Michael J. Donoghue, Aljos Farjon, Denis Filer, Sarah Mathews, Walter Jetz, Andrew B. Leslie

Faculty Publications

© 2019 The Author(s) Published by the Royal Society. All rights reserved. Biodiversity hotspots are important for understanding how areas of high species richness form, but disentangling the processes that produce them is difficult. We combine geographical ranges, phylogenetic relationships and trait data for 606 conifer species in order to explore the mechanisms underlying richness hotspot formation. We identify eight richness hotspots that overlap known centres of plant endemism and diversity, and find that conifer richness hotspots occur in mountainous areas within broader regions of long-term climate stability. Conifer hotspots are not unique in their species composition, traits or phylogenetic …

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