Digital Commons Network^™

Disruption Of G3bp1 Granules Promotes Mammalian Cns And Pns Axon Regeneration, Pabitra K. Sahoo, Manasi Agrawal, Nicholas Hanovice, Patricia J. Ward, Meghal Desai, Terika P. Smith, Haomin Sima, Jennifer N. Dulin, Lauren S. Vaughn, Mark H. Tuszynski, Kristy Welshhans, Larry I. Benowitz, Arthur W. English, John D. Houle, Jeffery L. Twiss

Faculty Publications

Depletion or inhibition of core stress granule proteins, G3BP1 in mammals and TIAR-2 in Caenorhabditis elegans, increases the growth of spontaneously regenerating axons. Inhibition of G3BP1 by expression of its acidic or “B-domain” accelerates axon regeneration after nerve injury, bringing a potential therapeutic strategy for peripheral nerve repair. Here, we asked whether G3BP1 inhibition is a viable strategy to promote regeneration in injured mammalian central nervous system (CNS) where axons do not regenerate spontaneously. G3BP1 B-domain expression was found to promote axon regeneration in the transected spinal cord provided with a permissive peripheral nerve graft (PNG) as well as …

Nanostructure Retention To 1100 °C In Soft-Templated Niobium Tungstates Using Dual-Carbon Strategy, Sean C. Wechsler, Alexander Gregg, Coby S. Collins, Santosh Kiran Balijepalli, Morgan Stefik

Faculty Publications

Mesoporous metal oxides (MMOs) have diverse applications including energy storage, catalysis, and separation membranes. Block polymer structure directing agents enable the control of morphology and pore size, however preservation of the nanostructure is often limited to a narrow range of heat treatment temperatures which constrains the tailoring of defect chemistries. High temperature treatments typically lead to collapse of the porous structure as surface area is reduced during crystal growth. Here, using a mesoporous niobium tungstate it is shown that neither in situ carbon generation nor ex situ carbon infiltration alone enable preservation of the ordered mesostructure at temperatures high enough …

Developing A Southern Ocean Marine Ecosystem Model Ensemble To Assess Climate Risks And Uncertainties, Kieran Murphy, Denisse Fierro-Arcos, Tyler Rohr, David Green, Camilla Novaglio, Katherine Baker, Kelly Ortega-Cisneros, Tyler D. Eddy, Cheryl S. Harrison, Simeon L. Hill, Patrick Eskuche-Keith, Camila Cataldo-Mendez, Colleen M. Petrik, Matthew Pinkerton, Paul Spence, Ilaria Stollberg, Roshni C. Subramaniam, Rowan Trebilco, Vivitskaia Tulloch, Juliano Palacios-Abrantes, Sophie Bestley, Daniele Bianchi, Philip Boyd, Pearse J. Buchanan, Andrea Bryndum-Buchholz, Marta Coll, Stuart Corney, Samik Datta, Jason D. Everett, Romain Forestier, Elizabeth A. Fulton, Vianney Guibourd De Luzinais, Ryan Heneghan

Faculty Publications

Climate change could irreversibly modify Southern Ocean ecosystems. Marine ecosystem model (MEM) ensembles can assist policy making by projecting future changes and allowing the evaluation and assessment of alternative management approaches. However, projected changes in total consumer biomass from the Fisheries and Marine Ecosystem Model Intercomparison Project (FishMIP) global MEM ensemble highlight an uncertain future for the Southern Ocean, indicating the need for a region-specific ensemble. A large source of model uncertainty originates from the Earth system models used to force FishMIP models, particularly future changes to lower trophic level biomass and sea-ice coverage. To build confidence in regional MEMs …

Global And Regional Marine Ecosystem Models Reveal Key Uncertainties In Climate Change Projections, Tyler D. Eddy, Ryan F. Heneghan, Andrea Bryndum-Buchholz, Elizabeth A. Fulton, Cheryl S. Harrison, Derek P. Tittensor, Heike K. Lotze, Kelly Ortega-Cisneros, Camilla Novaglio, Daniele Bianchi, Matthias Büchner, Catherine Bulman, William W.L. Cheung, Villy Christensen, Marta Coll, Jason D. Everett, Denisse Fierro-Arcos, Eric D. Galbraith, Didier Gascuel, Jerome Guiet, Steve Mackinson, Olivier Maury, Susa Niiranen, Ricardo Oliveros-Ramos, Juliano Palacios-Abrantes, Chiara Piroddi, Hubert Du Pontavice, Jonathan Reum, Anthony J. Richardson, Jacob Schewe, Lynne Shannon, Yunne Jai Shin, Jeroen Steenbeek

Faculty Publications

Climate change is affecting ocean temperature, acidity, currents, and primary production, causing shifts in species distributions, marine ecosystems, and ultimately fisheries. Earth system models simulate climate change impacts on physical and biogeochemical properties of future oceans under varying emissions scenarios. Coupling these simulations with an ensemble of global marine ecosystem models has indicated broad decreases of fish biomass with warming. However, regional details of these impacts remain much more uncertain. Here, we employ CMIP5 and CMIP6 climate change impact projections using two Earth system models coupled with four regional and nine global marine ecosystem models in 10 ocean regions to …

Modulators Of Energy Expenditure Accuracy In Adults With Overweight Or Obesity: E-Mechanic Secondary Analyses, Rachel Matthews, Christoph Höchsmann, Melissa L. Erickson, James L. Dorling, Guillaume Spielmann, Neil M. Johannsen, Timothy S. Church, Corby K. Martin

Faculty Publications

Purpose American College of Sports Medicine (ACSM) metabolic equations are used to estimate energy expenditure (EE) of physical activity and prescribe aerobic exercise to meet EE requirements. Limited evidence supports their accuracy in sedentary adults with overweight or obesity during controlled exercise interventions. The purpose of this study was to compare EE estimated by the ACSM walking equation versus EE measured by indirect calorimetry during a 24-wk aerobic exercise intervention, and identify potential modulators for their accuracy. Methods Data from the exercising groups (8 or 20 kcal·kg body weight-1·wk-1) of the E-MECHANIC study were utilized in this ancillary analysis (N …

From The Mountains To The Beach: Water Purification Ecosystem Services And Recreational Beach Use In Puerto Rico, Maya Corridore, Rebeca De Jesús Crespo, Mariam Valladares-Castellanos, Thomas Douthat

Faculty Publications

Recreational beach use is important for coastal economies and is influenced by water clarity, a trait that may be maintained by water purification ecosystem services (ESs). However, few studies have addressed these linkages. In this study, we ask the following questions: (1) Do watershed-scale water purification ecosystem services influence coastal water quality? (2) Does coastal water quality help explain beach visitation rates? To address these questions, we focused on Puerto Rico (PR), where coastal tourism has economic and cultural importance. We estimated water purification ESs using the Integrated Valuation of Ecosystem Services and Tradeoffs (InVEST), coastal water quality using long-term …

A 3d Superposition Approximation For Gamma Knife Dose Calculation, Payton H. Stone, Lam M. Lay, Raymi Ramirez, Daniel Neck, Connel Chu, Joyoni Dey, David Solis

Faculty Publications

Effective dose calculation is essential for optimizing Gamma Knife (GK) stereotactic radiosurgery (SRS) treatment plans. Modern GK systems allow independent sector activation, enabling complex dose distributions per shot. This study presents a dose approximation method designed to account for shot flexibility and generate 3D doses external to GammaPlan. A treatment plan was created with the TMR10 calculation for individual sector activations using a Radiosurgery Head Phantom. The resulting dose arrays established a basis set of sector-specific distributions, which were then referenced by shot parameters from the plan, allowing dose accumulation through superposition. This superposition approximation (SA) was compared to the …

The Contemporary Distribution Of Scincine Lizards Does Not Reflect Their Biogeographic Origin, Aniruddha Datta-Roy, Matthew C. Brandley, Christopher C. Austin, Aaron M. Bauer, David James Harris, Salvador Carranza, Kanishka D.B. Ukuwela, Anslem De Silva, Krystal A. Tolley, K. Praveen Karanth, Maitreya Sil

Faculty Publications

Aim: We assess the systematic relationships and historical biogeographic patterns in the subfamily Scincinae, a group of lizards that primarily inhabits the Afro-Madagascan and Saharo-Arabian regions with isolated lineages in Europe, North America, East Asia, India and Sri Lanka. The contemporary distribution of these lineages on the historical Laurasian and Gondwanan landmasses make scincines an ideal system to study the roles of vicariance and dispersal on a geologic scale of tens of millions of years. Location: Global. Taxon: Subfamily Scincinae (Family Scincidae). Methods: We conducted biogeographic analyses on a reconstructed, time-calibrated species tree of scincine genera, including members of the …

Increasing A-Type Co32− Substitution Decreases The Modulus Of Apatite Nanocrystals, Stephanie Wong, Abigail Eaton, Christina Krywka, Arun Nair, Christophe Drouet, Alix Deymier

Faculty Publications

Biological apatite mineral is highly substituted with carbonate (CO₃²⁻). CO₃²⁻ can exchange for either phosphate, known as B-type, or hydroxyl groups, known as A-type. Although the former has been extensively studied, A-type CO₃²⁻ substituted apatites are poorly understood. Therefore, A-type CO₃²⁻ apatites with biologically relevant levels of CO32− (1.7–5.8 wt%) were prepared and characterized. The addition of A-type CO₃²⁻ into the apatite structure caused the predicted expansion of the a-axis and contraction of the c-axis in the unit cell. This was accompanied by a significant modification in the atomic …

Basil And Swiss Chard: Edible Crops For Use In Floating Treatment Wetlands Improving Agricultural Runoff, Clare Escamilla, David R. Tyrpak, William H.J. Stronsnider, Sarah A. White

Faculty Publications

The plant species established within floating treatment wetlands (FTWs) influence nutrient removal efficiency. To enhance adoption of FTWs by agricultural producers, both economic and ecological benefits from FTWs are needed to increase their use within irrigation retention reservoirs. Thus, we ascertained the feasibility of growing food crops in FTWs by evaluating two edible plant species to determine survivability and nutrient accumulation when grown in FTWs. We quantified plant growth (at saleable/harvestable size), nutrient uptake in root and shoot tissues, and overall nutrient removal efficiency of sweet basil (Ocimum basilicum) and Swiss chard (Beta vulgaris) over a …

Modulating The Aqueous Micellar Reorganization Of Sequence-Defined Ionic Peptoid Block Copolymers By Ionizable Monomer Position And Solution Ph, Bailee N. Barrett, Pedram Azizihariri, Vijay T. John, Donghui Zhang

Faculty Publications

The micellar aggregation of singly charged sequence-defined ionic peptoid block copolymers can be finely tuned by adjusting the position of the ionizable monomer along the chain and varying the solution pH. The pH-induced structural reorganization of these micelles was found to depend on the position of the ionizable monomer along the chain, influencing the balance of the hydrophobic interactions, excluded volume effect, and electrostatic forces (i.e., charge repulsion, solvation of the ionic monomers, counterion association) that govern the micellar structure. As the solution pH increases, positioning the ionizable monomer closer to the junction of the hydrophobic and hydrophilic blocks causes …

Urbanization Impacts Dissolved Organic Matter Concentration And Quality In A Southeastern United States Watershed, Gwendolyn M. Hopper, Erik M. Smith, Jade Dormoy-Boulanger, Claudia R. Benitez-Nelson

Faculty Publications

Blackwater rivers are named due to their exceptionally high concentrations of chromophoric dissolved organic matter (CDOM). They are the predominant lotic ecosystem in the United States Southeastern Coastal Plain, a region experiencing some of the nation’s highest rates of development. This study assessed variability in DOM concentration and composition across forested to urbanized blackwater systems in coastal South Carolina, U.S. Dissolved organic carbon and nutrient concentrations as well as absorbance and fluorescence optical properties reveal that urban sites have lower concentrations, elemental ratios, and less complex DOM. In contrast, forested blackwater sites have concentrations an order of magnitude higher, elevated …

Changes In Foliar Chemistry And Nutrient Resorption In Northern Hardwood Forests In Response To Long-Term Experimental Nitrogen And Phosphorus Addition, Jenna M. Zukswert, Timothy J. Fahey, Matthew A. Vadeboncoeur, Daniel S. Hong, Ruth D. Yanai

Faculty Publications

Northern hardwood forests have long been assumed to be primarily nitrogen limited, but may often be co-limited by multiple elements. Nutrient limitation can be inferred through responses of foliar and litter chemistry to nutrient addition over time. We compared community-level foliar and litter chemistry and resorption efficiency in a long-term, factorial nitrogen (N) and phosphorus (P) fertilization study across 10 forest stands at three sites in New Hampshire, where N and P were added annually. We measured N, P, calcium (Ca), magnesium (Mg), and potassium (K) in foliage from codominant trees and in fresh litter in 2008–2010 (pretreatment) and again …

Impact Of Voluntary Exercise On Systemic Inflammation In A 2? Hit Model Of Heart Failure With Preserved Ejection Fraction, Heather Quiriarte, Eunhan Cho, Youyoung Kim, Jake E. Doiron, Gregory Davis, James Stampley, Robert C. Noland, Zhen Li, Sanjiv J. Shah, Brian A. Irving, Guillaume Spielmann, David J. Lefer, Timothy D. Allerton

Faculty Publications

No abstract provided.

Predicting Diabetes Self-Management Education Engagement: Machine Learning Algorithms And Models, Xiangxiang Jiang, Gang Lv, Minghui Li, Jing Yuan, Z Kevin Lu

Faculty Publications

Introduction Diabetes self-management education (DSME) is endorsed by the American Diabetes Association (ADA) as an essential component of diabetes management. However, the utilization of DSME remains limited in the USA. This study aimed to investigate current DSME participation among the older population and to identify comprehensive factors of DSME engagement through employing various machine learning (ML) models based on a US nationally representative survey linked to claims data.

Research design and methods Data from the Medicare Current Beneficiary Survey were employed, and this study included data on US Medicare beneficiaries with diabetes from 2017 to 2019. Comprehensive variables following the …

Streamlined Production, Protection, And Purification Of Enzyme Biocatalysts Using Virus-Like Particles And A Cell-Free Protein Synthesis System, Seung O. Yang, Joseph P. Talley, Gregory H. Nielsen, Kristen M. Wilding, Bradley Charles Bundy

Faculty Publications

Enzymes play an essential role in many different industries; however, their operating conditions are limited due to the loss of enzyme activity in the presence of proteases and at temperatures significantly above physiological conditions. One way to improve the stability of these enzymes against high temperatures and proteases is to encapsulate them in protective shells or virus-like particles. This work presents a streamlined, three-step, cell-free protein synthesis (CFPS) procedure that enables rapid in vitro enzyme production, targeted encapsulation in protective virus-like particles (VLPs), and facile purification using a 6× His-tag fused to the VLP coat protein. This process is performed …

A Numerical Assessment Of Ocean Alkalinity Enhancement Efficiency On A River-Dominated Continental Shelf—A Case Study In The Northern Gulf Of Mexico, Yanda Ou, Z. George Xue, Xinping Hu

Faculty Publications

A robust high-resolution coupled hydrodynamic-biogeochemical model was applied to the northern Gulf of Mexico to assess the efficiency of river- and ocean-sourced ocean alkalinity enhancement (OAE). Sensitivity tests indicate that the effectiveness of OAE-induced CO2 uptake is primarily influenced by the amount of alkalinity introduced and local wind-driven mixing, with the former determining the overall uptake and the latter affecting short-term variability. Compared to ocean-sourced OAE (direct ocean release), river-sourced OAE (elevated river alkalinity) is more effective and sustainable. River-sourced OAE has higher CO2 uptake efficiency with reduced spatial and temporal uncertainty and greater overall CO2 uptake. For river-sourced OAE, …

An Integrated Global-To-Regional Scale Workflow For Simulating Climate Change Impacts On Marine Ecosystems, Kelly Ortega-Cisneros, Denisse Fierros-Arcos, Max Lindmark, Camilla Novaglio, Phoebe Woodworth-Jefcoats, Tyler D. Eddy, Marta Coll, Elizabeth Fulton, Ricardo Oliveros-Ramos, Jonathan Reum, Yunne Jai Shin, Cathy Bulman, Leonardo Capitani, Samik Datta, Kieran Murphy, Alice Rogers, Lynne Shannon, George A. Whitehouse, Ezekiel Adekoya, Beatriz S. Dias, Alba Fuster-Alonso, Cecilie Hansen, Bérengère Husson, Vidette Mcgregor, Alaia Morell, Hem Nalini Morzaria Luna, Jazel Ouled-Cheikh, James Ruzicka, Jeroen Steenbeek, Ilaria Stollberg, Roshni C. Subramaniam, Vivitskaia Tulloch, Andrea Bryndum-Buchholz

Faculty Publications

As the urgency to evaluate the impacts of climate change on marine ecosystems increases, there is a need to develop robust projections and improve the uptake of ecosystem model outputs in policy and planning. Standardizing input and output data is a crucial step in evaluating and communicating results, but can be challenging when using models with diverse structures, assumptions, and outputs that address region-specific issues. We developed an implementation framework and workflow to standardize the climate and fishing forcings used by regional models contributing to the Fisheries and Marine Ecosystem Model Intercomparison Project (FishMIP) and to facilitate comparative analyses across …

A Data-Driven Approach To Enhance The Prediction Of Bacteria–Metabolite Interactions In The Human Gut Microbiome Using Enzyme Encodings And Metabolite Structural Embeddings, Gopal Srivastava, Michal Brylinski

Faculty Publications

Background: The human gut microbiome is critical for host health by facilitating essential metabolic processes. Our study presents a data-driven analysis across 312 bacterial species and 154 unique metabolites to enhance the understanding of underlying metabolic processes in gut bacteria. The focus of the study was to create a strategy to generate a theoretical (negative) set for binary classification models to predict the consumption and production of metabolites in the human gut microbiome. Results: Our models achieved median balanced accuracies of 0.74 for consumption predictions and 0.95 for production predictions, highlighting the effectiveness of this approach in generating reliable negative …

Interactive Effects Of Co2, Temperature, And Nitrate Limitation On The Growth And Physiology Of Strain Ccmp 1334 Of The Marine Cyanobacterium Synechococcus (Cyanophyceae), Alyssa K. Sharbaugh, Edward A. Laws

Faculty Publications

The marine cyanobacterium Synecococcus sp. (CCMP 1334) was grown in a continuous culture system on a 12:12 h light:dark cycle at all combinations of low and high pCO2 (400 and 1000 ppmv, respectively), nutrient availability (nitrate-limited and nutrient-replete conditions), and temperatures of 21, 24, 28, 32, and 35°C. The maximum nutrient-replete growth rate was ~1.15 day⁻¹ at 32–35°C. Median nutrient-replete growth rates were higher at 1000 ppmv than at 400 ppmv pCO2 at all temperatures. Carbon:nitrogen ratios were independent of pCO2 at a fixed relative growth rate (i.e., growth rate ÷ nutrient-replete growth rate) but decreased with increasing temperature. …

Butterfly Species Vary In Sex-Specific Sodium Accumulation From Larval Diets, Luis Y. Santiago-Rosario, Alexander M. Shephard, Emilie Snell-Rood, Achim D. Herrmann, Kyle E. Harms

Faculty Publications

Sodium is essential for animals, and its heterogeneous distribution can cause a range of phenomena, from sodium-seeking behaviours to impacting their performance. Although sodium content in soils and plants is relatively well documented, data for higher trophic levels are limited. Knowledge of the variation in sodium in lower trophic levels could have implications for understanding the behaviour and physiology of species at higher levels. We investigated the variation in tissue sodium concentration between males and females of four butterfly species. Puddling behaviour of Lepidoptera suggests sodium needs of males are generally greater than females, thus, we predicted males would accumulate …

Increased Expression Of The Small Lysosomal Gene Svip In The Drosophila Gut Suppresses Pathophysiological Features Associated With A High-Fat Diet, Brennan M. Mercola, Tatiana V. Villalobos, Jocelyn E. Wood, Ankita Basu, Alyssa E. Johnson

Faculty Publications

Lysosomes are digestive organelles that are crucial for nutrient sensing and metabolism. Lysosome impairment is linked to a broad spectrum of metabolic disorders, underscoring their importance to human health. Thus, lysosomes are an attractive target for metabolic disease therapies. In previous work, we discovered a novel class of tubular lysosomes that are morphologically and functionally distinct from traditionally described vesicular lysosomes. Tubular lysosomes are present in multiple tissues, are broadly conserved from invertebrates to mammals, are more proficient at degrading autophagic cargo than vesicular lysosomes, and delay signs of tissue aging when induced ectopically. Thus, triggering tubular lysosome formation presents …

Post-Term Births As A Risk Factor For Small For Gestational Age Births And Infant Mortality In Brazil, Mexico, And Palestinian Refugees: An Analysis Of Electronic Birth Records, Zeina Jamaluddine, Lorena Suarez Idueta, Enny S. Paixao, Julia M. Pescarini, Hala Ghattas Ph.D., Miho Sato, Akihiro Seita, Luis A. Martinez-Juarez, Mauricio L. Barreto, Eric O. Ohuma, Louise T. Day, Oona M.R. Campbell, Hannah Blencowe

Faculty Publications

Background:

Post-term pregnancy, defined as reaching or exceeding 42 + 0 weeks of gestation, is known to be associated with unfavourable birth outcomes. High-income countries have responded to this risk by widely adopting labour induction protocols in late-term, but many low- and middle-income countries have not. However, understanding underlying mechanisms linking post-term births to adverse newborn and infant outcomes remains limited.

Objective:

To investigate the (a) prevalence of post-term, (b) the risk factors associated with post-term (c) the association between post-term births and the risk of small-for-gestational-age (SGA) neonates and of infant mortality in middle-income settings.

Methods:

We used existing …

Earliest Ancient Maya Salt Production In Southern Belize: Excavations At Jay-Yi Nah, Heather Mckillop, E. Cory Sills

Faculty Publications

Salt works along the Yucatan coasts of Mexico and Belize provide a record of salt production for inland trade during the height of Late Classic Maya civilisation (AD 550-800). At the Paynes Creek Salt Works in Belize, production focused on the creation of salt cakes by boiling brine in pots supported over fires in dedicated salt kitchens. Underwater excavations at the Early Classic (AD 250-550) site of Jay-yi Nah now indicate there was a longer and evolving tradition of salt making in the area, one that initially employed large, incurved bowls to meet local or down-the-line trade needs before inland …

The Built Environment And Place Attachment: Insights From Japanese Cities, Juiling Li, Mohammed Javad Koohsari, Andrew T. Kaczynski, Ryo Tanimoto, Reo Watanabe, Tomoki Nakaya, Yufeng Luo, Jing Zhao, Akitomo Yasunaga, Koichiro Oka, Tomoya Hanibuchi

Faculty Publications

Objective

Methods

Results

Pilot Study: Initial Investigation Suggests Differences In Emt-Associated Gene Expression In Breast Tumor Regions, Kylie L. King, Hamed Abdollahi, Zoe Dinkel, Alannah Akins, Homayoun Valafar, Heather Dunn

Faculty Publications

Triple negative breast cancer (TNBC) is the most aggressive subtype and disproportionately affects African American women. The development of breast cancer is highly associated with interactions between tumor cells and the extracellular matrix (ECM), and recent research suggests that cellular components of the ECM vary between racial groups. This pilot study aimed to evaluate gene expression in TNBC samples from patients who identified as African American and Caucasian using traditional statistical methods and emerging Machine Learning (ML) approaches. ML enables the analysis of complex datasets and the extraction of useful information from small datasets. We selected four regions of interest …

Population Variability Across Geographical Ranges: Perspectives And Challenges, Cleber Ten Caten, Tad Dallas

Faculty Publications

Populations fluctuate over time and across geographical space, and understanding how different factors contribute to population variability is a central goal in population ecology. There is a particular interest in identifying trends of population variability within geographical ranges as population densities of species can fluctuate substantially across geographical space. A common assumption is that populations vary more near species geographical range edges because of unsuitable environments and higher vulnerability to environmental variability in these areas. However, empirical data rarely support this expectation, suggesting that population variability is not related to its position within species geographical ranges. We propose that performance …

Amplifying Women’S Voices In Menopause Research: The Importance Of Inclusive Perspectives, Camille Cronin, Sarah B. Donevant Phd, Rn, Ccrn, Kerri-Ann Hughes, Marja Kaunonen, Jette Marcussen, Rhonda Wilson

Faculty Publications

Menopause, a significant life transition for half the global population, intersects biological, cultural and social dimensions. Despite its universal occurrence, menopause research has historically been dominated by biomedical perspectives, often neglecting women's voices and diverse experiences. This article highlights the importance of including women's perspectives in menopause research to ensure relevance, accuracy and equity. It explores cultural variations in menopause experiences, the impact of socioeconomic status and the often-overlooked emotional and psychological dimensions. This article advocates for participatory approaches, emphasising that women's involvement enhances research design, implementation and policy development. Evidence-based interventions that are tailored to the individual can better …

The Design And Cell-Free Protein Synthesis Of A Pembrolizumab Single-Chain Variable Fragment, Landon E. Ebbert, Tyler J. Free, Mehran Soltani, Bradley Charles Bundy

Faculty Publications

Background/Objectives: Cancer is a leading cause of death. However, recently developed immunotherapies have shown significant promise to improve cancer treatment outcomes and survival rates. Pembrolizumab, a cancer immunotherapy drug, enables a strong T-cell response specifically targeting cancer cells to improve patient outcomes in more than 16 types of cancer. The increasing demand for pembrolizumab, the highest selling drug in 2023, increases global dependence on drug production, which can be vulnerable to supply chain disruptions. Methods: Cell-free protein synthesis (CFPS) is a rapid in vitro protein production method that could provide the production of an immunotherapy drug in an emergency and …

Associations Between Social Determinants Of Health And Mental Health Disorders Among U.S. Population: A Cross-Sectional Study, S. Tanarsuwongkul

Faculty Publications

Aims

The impact of social determinants of health (SDOH) on mental health is increasingly realized. A comprehensive study examining the associations of SDOH with mental health disorders has yet to be accomplished. This study evaluated the associations between five domains of SDOH and the SDOH summary score and mental health disorders in the United States.

Methods

We analyzed data from a diverse group of participants enrolled in the All of Us research programme, a research programme to gather data from one million people living in the United States, in a cross-sectional design. The primary exposure was SDOH based on Healthy …