Digital Commons Network^™

Association Between Cholinesterase Inhibitor-Overactive Bladder Antimuscarinic Prescribing Cascade And Risk Of Delirium And Falls Among Individuals Living With Dementia, Sarah Beth Tucker, Bryan L. Love Pharm D., Chijoke M. Okeke, Erin D. Zwick, Chengwen Teng Pharm.D., Ph.D., Jingkai Wei, Ibraheem M. Karaye, Saud Alsahali, Krithika Rajagopalan, Ismaeel Yunusa Ph.D.

Faculty Publications

Background

Prescribing cascades occur when cholinesterase inhibitor (ChEI)-induced urinary incontinence is misinterpreted as a new condition, leading to overactive bladder (OAB) antimuscarinic initiation. We evaluated whether the ChEI-OAB antimuscarinic prescribing cascade was associated with delirium or falls compared with mirabegron in older adults living with dementia.

Methods

We conducted a retrospective cohort study using the Anlitiks All-Payor Claims database (2015–2020). Participants were adults aged ≥ 65 years with dementia newly prescribed a ChEI with no prior ChEI or OAB therapy (180 days). A 60-day window identified OAB treatment initiation after ChEI therapy. Exposures were OAB antimuscarinics or mirabegron. Outcomes were …

Wrky Transcription Factors: Integral Regulators Of Defence Responses To Biotic Stress In Crops, Dongjiao Wang, Ruize Zhang, Wenhui Zou, Yuanyuan Zhang, Wanying Zhao, Tingting Sun, Qibin Wu, Zheng Qing Fu, Youxiong Que

Faculty Publications

Crops are continually challenged by biotic stresses, including fungal, bacterial and viral pathogens and insect pests, which cause substantial yield and quality losses worldwide. WRKY transcription factors constitute a plant-specific and functionally diverse family that is central to immune regulation. Recent advances in genomic resources and multi-omics approaches have accelerated the identification and functional characterisation of WRKYs in crops. This review summarises the structural features and classification of WRKY genes and their genome-wide distribution across crop species. It also synthesises WRKY-centred regulatory modules that mediate resistance to major classes of biotic stress. In antifungal defence, WRKYs reinforce pattern- and effector-triggered …

Examining The Psychometric Structure Of An Instrument To Measure Students’ Interests And Motivation In Science Learning: Factor Analysis And Measurement Invariance, Fuhui Tong, Shifang Tang, Zhuoying Wang, Beverly J. Irby

Faculty Publications

In this study, we examined the psychometric properties (reliability, validity, and underlying factor structure) and measurement invariance of a researcher-developed instrument: Motivated Strategies for Science Learning (MSSL). Data were collected from 2765 fifth-grade students across [state withheld] school districts. Results from exploratory and confirmatory factor analyses suggested satisfactory psychometric properties of MSSL. We further identified strong evidence to support configural, metric, scalar, and strict invariance across school location groups (i.e., rural and non-rural), confirming that the instrument can accurately capture the construct of science learning motivation among fifth-grade students from both rural and non-rural Texas schools. The study provides the …

Characterizing The Unique Chemical Imprint Of On-Axis, Lower-Temperature Hydrothermal Flow To The Deep Ocean (Southern East Pacific Rise, 16.5°–18.0°S), Laura E. Moore, Randelle M. Bundy, Joseph A. Resing, Scott M. White, Tamara Baumberger, Peter N. Sedwick, Nathaniel J. Buck, Anson M. Antriasian, Isaac Keohane

Faculty Publications

In addition to high-temperature vents, lower-temperature flow (LTF) (< 300°C) is abundant along mid-ocean ridges and contributes globally-important fluxes of heat and water along with largely-unconstrained geochemical influences on the ocean. We examined the impact of on-axis LTF on the chemical composition of the overlying water column (< 40 m above seafloor) along the 16.5°–18.0°S sector of the ultrafast-spreading southern East Pacific Rise using autonomous underwater vehicle Sentry surveys and conductivity-temperature-depth rosette casts. LTF sites were typically spatially isolated from high-temperature systems and imparted unique chemical signatures to the overlying ocean. Water column samples impacted by LTF exhibited low particulate iron:sulfur ratios and high methane: total-dissolvable manganese ratios, whereas samples influenced by high-temperature venting exhibited opposite trends. We confirmed that LTF imparts a distinct and measurable chemical signature to the water column, independent from high-temperature vents. Isolated, on-axis LTF will be important to consider when assessing hydrothermal circulation impacts upon ocean biogeochemistry.

Roles Of Mads-Box Transcription Factors In Plant Responses To Abiotic And Biotic Stresses, Na Liu, Zihao Liu, Guangxiang Tian, Shijia Zhao, Hao Chu, Yiheng Hu, Yingfan Zhao, Yanyan Zhang, Kun Cheng, Daowen Wang, Wenming Zheng, Zhengqing Fu, Xu Wang

Faculty Publications

Plants deploy sophisticated adaptive mechanisms to mitigate the detrimental effects of abiotic stresses (drought, salinity, temperature extremes, and heavy metals) and biotic stresses (pathogens and senescence) on growth and productivity. Central to these responses are transcription factors (TFs) that orchestrate stress-responsive gene networks. Among TF families, MADS-box proteins, characterized by their evolutionarily conserved DNA-binding domain, function as pivotal regulators of developmental plasticity and stress adaptation. While recent advances have clarified their roles in abiotic stress tolerance, a systematic integration of their functions in biotic stress responses has yet to be achieved. This review synthesizes current knowledge on how MADS-box TFs …

Changes In Depression, Eating, Sleep, And Emotion Regulation In Air Force Rotc Cadets After The 12-Wk Star Training Program, Antonella V. Schwarz, Hunter Haynes, Sheena Puleali’I, Jacob Mota, Molly F. Johnson, Maria G. Kaylor, Andrew Addison, Robyn Braun-Trocchio, Austin J. Graybeal

Faculty Publications

Introduction: – Reserve Officer Training Corps (ROTC) cadets must balance collegiate demands with military preparation, leaving them vulnerable to psychological stressors. While structured strength and conditioning (S&C) programs enhance physical readiness, their impact on psychological health in cadet populations remains unclear. This study evaluated changes in depression, eating behaviors, sleep quality, and emotion regulation during a 12-wk S&C program. Methods: – Forty-nine U.S. Air Force ROTC cadets (21 female, 28 male; age: 20 ± 2 yr; body mass index: 24.2 ± 4.4 kg·m⁻²; body fat %: 27.1 ± 9.0%) completed the Supporting Tactical Athlete Readiness (STAR) program, a …

New Species Of Kronosvirus Bacteriophages That Infect Caulobacter Strain Cbr1, Tannaz Mohammadi, Austin Millwood, Maherah Shaik, Bert Ely

Faculty Publications

Caulobacter segnis strain CBR1 enhances the germination rate and total biomass of Arabidopsis plants. Since bacteriophages are usually present in the rhizosphere, we isolated three additional bacteriophages, designated TMCBR2, TMCBR3, and W2, that can replicate using CBR1 as the host strain. The genome sizes and morphologies of the new phages were similar to those of the previously isolated Kronos phage, and when we compared the nucleotide sequence of these new phage genomes, we found only minor differences among the four phage genomes. Pairwise sequence comparisons indicated that the phage genomes should be grouped into three separate species within Kronosvirus genus. …

Synthesis Of Copper-Phenanthroline Complexes: A Solvothermal-Compatible Approach For The Exploration Of Metal Complexes, Yunping Zhoujin, Michael Anim Safo, Navindra Keerthisinghe, Mark D. Smith, Sophya Garashchuk, Hans Conrad Zur Loye

Faculty Publications

Inorganic–organic hybrid materials have been widely investigated for their applications in catalysis, optics, magnetism, and biomedicine. Copper halide complexes are of particular interest due to their structural diversity and physicochemical properties. Conventional crystal growth approaches, such as slow evaporation and hydro(solvo)thermal synthesis, typically require extended reaction times and often favor thermodynamically stable phases. In this study, we prepared ten copper-phenanthroline halide (X = Cl, Br, and I) complexes using both traditional hydrothermal reactions and microwave-assisted hydrothermal methods and obtained [CuI(C₁₂H₈N₂)₂][I₃], [C₁₂H₉N₂][CuI₂]·(H_{2 …}

Roadmap On Artificial Intelligence-Augmented Additive Manufacturing, Ali Zolfagharian, Liuchao Jin, Qi Ge, Wei-Hsin Liao, Andrés Díaz Lantada, Francisco Franco Martínez, Tianyu Zhang, Tao Liu, Charlie C.L. Wang, Mohammad Hossein Mosallanejad, Reza Ghanavati, Abdollah Saboori, Alejandro De Blas De Miguel, William Solórzano-Requejo, Yi Cai, Xiangyang Dong, Huangyi Qu, Najmeh Samadiani, Guangyan Huang, Austin Downey, Yanzhou Fu, Lang Yuan

Faculty Publications

Artificial intelligence-augmented additive manufacturing (AI2AM) represents a transformative frontier in digital fabrication, where artificial intelligence (AI) is embedded not as a peripheral tool, but as a central framework driving intelligent, adaptive, and autonomous additive manufacturing (AM) systems. The objective of this Roadmap is to present a comprehensive vision of the state-of-the-art developments in AI2AM while charting the future trajectory of this rapidly emerging field. As AM applications continue to expand across diverse sectors, conventional design and control strategies face growing limitations in scalability, quality assurance, and material complexity. AI uses tools like computer vision, generative design, and large language models …

Beyond A Protagonist Bias In Narrative Identity Research: Methods For Identifying Master Narratives In Interview Data, Andrew D. Coppens, Jayson Seaman, Cindy Hartman

Faculty Publications

This article advances a methodological shift in narrative identity research by addressing the field’s protagonist bias – the tendency to rely on first-person autobiographical accounts as the primary evidence for identifying cultural master narratives. We integrate Erikson’s psychosocial identity framework, Vygotsky’s “tool and result” methodological insight, and sociolinguistic approaches to narrative to develop a three-stage analytic logic: (1) identifying small-n narratives through scenes conveyed in discourse; (2) grouping these into Big-N narratives that cohere thematically across scenes (Tannen, 2007, 2008); and (3) assessing candidate master narratives using McLean and Syed’s (2016) five criteria. We demonstrate this approach through a case …

Regulation Of Zygotic Genome Activation By The Nucleocytoplasmic Ratio, Lily Acker, Hui Chen

Faculty Publications

During early development, embryos undergo the maternal-to-zygotic transition (MZT), when control of development shifts from maternal factors to the newly activated zygotic genome. Decades of studies in various model organisms suggest that the nucleocytoplasmic (N/C) ratio is a key regulator of zygotic genome activation (ZGA), though this relationship is more nuanced in some organisms than others. Changing the nuclear content, nucleus size or cell size has been shown to shift the timing of ZGA. Mechanistically, the N/C ratio is linked to fundamental cellular processes that regulate genome activities, including nuclear import, repressor titration, activator accumulation, cell cycle lengthening, and chromatin …

Association Between The Dietary Index For Gut Microbiota (Di-Gm) And Colorectal Cancer In The Plco Cohort, Bezawit E. Kase, Angela D. Liese Ph.D., Jiajia Zhang Ph.D., Elizabeth Angela Murphy, Susan E. Steck Phd, Mph, Rd

Faculty Publications

Objectives: The study aimed to examine the association between a dietary index for gut microbiota (DI-GM) and the risk of incident colorectal cancer (CRC). Clarifying the role of diet-induced alterations in the composition and function of gut microbiota on the development of CRC can contribute to prevention efforts. Methods: Participants from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening trial enrolled in the intervention arm and who completed baseline assessments were included in the analysis (n = 55,685). The DI-GM is a literature-derived index used to score diet quality in terms of maintaining healthy gut microbiota. A time-dependent Cox model …

Association Between The Dietary Index For Gut Microbiota (Di-Gm) And Colorectal Cancer In The Plco Cohort, Bezawit E. Kase, Angela D. Liese, Jiajia Zhang, Elizabeth Angela Murphy, Susan E. Steck

Faculty Publications

Objectives: The study aimed to examine the association between a dietary index for gut microbiota (DI-GM) and the risk of incident colorectal cancer (CRC). Clarifying the role of diet-induced alterations in the composition and function of gut microbiota on the development of CRC can contribute to prevention efforts. Methods: Participants from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening trial enrolled in the intervention arm and who completed baseline assessments were included in the analysis (n = 55,685). The DI-GM is a literature-derived index used to score diet quality in terms of maintaining healthy gut microbiota. A time-dependent Cox model …

Role Of Wadsley Defects And Cation Disorder To Enhance Monb12O33 Diffusion, Cj Sturgill, Manish Kumar, Nima Karimitari, Iva Millisavljevic, Coby S. Collins, Aaron Hegler, Hsin-Yun Joy Chao, Santosh Kiran Balijepalli, Scott T. Misture, Christopher Sutton, Morgan Stefik

Faculty Publications

Wadsley-Roth (WR) niobates have emerged as high-rate anode materials that can combine rapid ionic diffusion with good electronic conductivity. WR compounds have been defect-enhanced by limited annealing, however, such materials often contain multiple types of defects. In particular, both Wadsley defects (variable block size) and transition metal disorder have the potential to modify transport rates, however the corresponding effects are not well understood mechanistically. Here, MoNb12O33 (MNO) was calcined at two different temperatures to compare a defect-rich condition (MNO-800) with a proximal order-rich condition (MNO-900) as assessed through XRD, XANES, EXAFS, and STEM characterizations. Galvanostatically cycled lithium half cells of …

A Livelihood Intervention Improved Nutritional, Mental Health And Sexual Health Outcomes Among Hiv-Affected Adolescents In Western Kenya: Results From The Shamba Maisha Randomised Controlled Trial, Sheri D. Weiser, Lila Aziz Sheira, Pauline Wekesa, Jennifer Monroe Zakaras, Edward A. Frongillo Jr. Ph.D., Elly Weke, Jason M. Nagata, Amy A. Conroy, Marguerita Lightfoot, Torsten B. Neilands, Lisa M. Butler, Elizabeth A. Bukusi, Craig R. Cohen, Maricianah Atieno Onono

Faculty Publications

Introduction Interventions that address household-level factors, including food insecurity (FI) and poverty, may reduce HIV risk and improve sexual and reproductive health (SRH) among adolescent girls and young women (AGYW).

Methods This cluster randomised controlled trial in Kenya assessed AGYW living in households of adults enrolled in Shamba Maisha (SM). SM was a multisectoral agricultural livelihood intervention designed to improve HIV health. At the trial end, we used linear and logistic regressions to compare differences between the intervention and control arms in FI, and mental health among AGYW-caregiver pairs and SRH outcomes among the AGYW, accounting for clusters with robust …

Transcranial Alternating Current Stimulation As An Adjuvant For Nonfluent Aphasia: A Proof-Of-Concept Study, Lynsey M. Keator, Lisa Johnson, Roger Newman-Norlund Ph.D., Kyler Spell, Samaneh Nemati, Leigh Ann Spell, Dirk B. Den Ouden, Chris Rorden, Julius Fridriksson Ph.D.

Faculty Publications

Effective rehabilitation tools are essential for improving language outcomes in chronic aphasia. Speech entrainment is a behavioral treatment that has shown promise in enhancing speech output in nonfluent aphasia, potentially by acting as an external mechanism to synchronize anterior and posterior language regions in the left hemisphere. Transcranial alternating current stimulation has been hypothesized to enhance functional connectivity between brain regions by amplifying endogenous oscillations. This proof-of-concept study explored whether high-definition tACS (HD-tACS) could improve speech fluency in nonfluent aphasia when paired with speech entrainment. In a double-blind, pseudorandomized study, 1 mA of HD-tACS at 7 Hz was applied to …

Circulating Levels Of Insulin-Like Growth Factor I (Igf-I) And Risk Of Multiple Myeloma: An Observational And Mendelian Randomisation Study, Yolanda Benavente, Sara Hermosa, Nikos Papadimitriou, Alyssa I. Clay-Gilmour Ph.D., Elizabeth E. Brown, Jonathan N. Hofmann, Nathaniel Rothman, Qin Lan, Sonja I. Berndt, Demetrius Albanes, Mark Purdue, Mitchell J. Machiela, Stephen J. Chanock, Parveen Bhatti, Wendy Cozen, Aaron Norman, Susan L. Slager, James R. Cerhan, Vincent Rajkumar, Et. Al.

Faculty Publications

No abstract provided.

Of Epistemes And Insects: How Drosophila And Butterflies Shape Our Understanding Of Radiation Risk, Donna M. Goldstein, Magdalena E. Stawkoski

Faculty Publications

This paper explores the complexities of extrapolating insect data to understand nuclear exposure effects on humans. Within radiation research, animal studies are invaluable tools for understanding biological effects of radiation exposure. However, data are often employed selectively, exposing unsettled science in extrapolating animal data to human radiation effects. Here we focus on our understanding of the genetic effects of radiation exposure, and how the debates about the long-term effects on humans were molded by research carried out on the model organism known as Drosophila; disagreements among scientists occurred within the constraints of research on this model organism, creating what …

Using Mobile Devices To Support Outdoor Stem Learning In Rural Contexts: An Embedded Mixed-Methods Study, Jayson Seaman, Amanda Bastoni, Andrew D. Coppens, Cindy L. Hartman, Courtney Lachaine, Katelyn Moscouver, Janet Gronneberg

Faculty Publications

Background: Rural youth face barriers to involvement in effective Science, Technology, Engineering, and Math (STEM) learning experiences, leading to persistent underrepresentation in STEM fields. Purpose: This study examined the feasibility of using mobile devices to engage rural youth in informal STEM learning (ISL) during free-choice, outdoor recreational activities. We assessed outcomes of a 10-month intervention related to STEM interest, identity, and future planning. Method: Fifty-four youth ages 12 to 17 completed monthly STEM challenges delivered via a mobile platform, aligned with connected learning and free-choice learning principles. Surveys measured pre/post changes in STEM supports, STEM confidence, and …

Remote Language Assessment In School-Age Children With Phelan–Mcdermid Syndrome And Genotype–Phenotype Correlation, Sarah Quadri-Valverde, Jessica Klusek Ph.D., Ccc-Slp, Linda D. Ward, Diana Ivankovic, Nancy Powers, Vijay Shankar, Rachel A. Lyman, Trudy F.C. Mackay, William Bridges, Katy Phelan, Chris Rogers, Luigi Boccuto, Sara M. Sarasua

Faculty Publications

People with Phelan–McDermid syndrome (PMS) have reduced speech and language abilities, yet little research has profiled the communication abilities in this population. The purpose of this study was threefold: identifying the language and communication profiles of school-aged children with PMS, identifying genetic contributions to language and communication abilities, and determining the feasibility of remote data collection for research purposes. A speech language pathologist used standardized assessments and direct evaluations by video conferencing to evaluate language and communication abilities. Sixteen children and adolescents were evaluated: 5 with SHANK3 pathogenic variants, 9 with 22q13 deletions including SHANK3 (PMS-SHANK3 related), and 2 …

Crepe Myrtle Bark Scale (Acanthococcus Lagerstroemiae) And Sooty Mold (Capnodium Sp.) Decrease Bloom And Fruit Number In ‘Natchez’ Crepe Myrtle (Lagerstroemia Xfauriei ‘Natchez’), Derald A. Harp, Beatriz Ruiz, Kara Bailey, Pedro Castillo, Phoebe Alvarez

Faculty Publications

Crepe myrtle bark scale (CMBS) (Acanthococcus lagerstroemiae) is an important pest of crepe myrtle in Texas, and infestations are accompanied by excessive growth of sooty mold (SM) that will cover stems, and, in severe cases, leaves. These combine to create significant stress on the plant, and anecdotal evidence suggests a decrease in bloom number under heavy infestation. In an existing planting of 24 ‘Natchez’ crepe myrtle in four blocks, three trees were randomly chosen in each block and treated with either a dinotefuran (year 1) or imidicloprid (year 2) drench. The three remaining trees were untreated. In February of year …

The Sortee Guidelines For Data And Code Quality Control In Ecology And Evolutionary Biology, Joel L. Pick, Bethany J. Allen, Benedicte Bachelot, Kevin R. Bairos-Novak, Jack A. Brand, Barbara Class, Tad Dallas, Pietro B. D'Amelio, Erola Fenollosa, Esteban Fernández-Juricic, Dylan G. Gomes, Matthew J. Grainger, Thomas Guillemaud, John Christian, Ruby Krasnow, Malgorzata Lagisz, Sebastian Lequime, Daniel S. Maynard, Shinichi Nakagawa, Rose E. O'Dea, Et. Al.

Faculty Publications

Open data and code are crucial to increasing transparency and reproducibility, and in building trust in scientific research. However, despite an increasing number of journals in ecology and evolutionary biology mandating for data and code to be archived alongside published articles, the amount and quality of archived data and code, and subsequent reproducibility of results, has remained worryingly low. As a result, a handful of journals have recruited dedicated data editors, whose role is to help authors increase the overall quality of archived data and code. There is, however, a general lack of consensus around what a data editor should …

Roadmap: Integrating Artificial Intelligence In Structural Health Monitoring Systems, Simon Laflamme, Erik Blasch, Flippo Ubertini, Zheng Liu, John Wertz, Christine Knott, Matthew Cherry, Eric Lindgren, Fu-Kuo Chang, Amrita Kumar, Jack Poole, Keith Worden, Austin Downey, Jie Wei, Patrick F. Musgrave, Adrian S. Wong, Guiseppe Quaranta, Marco Martino Rosso, Giuseppe Carlo Marano, Yu Chen, Et. Al.

Faculty Publications

Advances in computing and machine learning (ML) methods have led to a rapid rise in artificial intelligence (AI) research and applications in many fields. AI research benefitted from advances in computation hardware, collection and distribution of large data sets, and proliferation of software techniques. AI techniques include ML for provable results, deep learning for data exploration, reinforcement learning for control, and active learning for adaptive systems. Likewise, AI algorithms can handle large amounts of data, construct unknown representations, and provide a direct link between data and classification for decision making. These unmatched capabilities have been seen as a path to …

Ulk4 And Cdkn2a Polymorphisms Influence The Risk Of Developing Monoclonal Gammopathy Of Undetermined Significance, José Manuuel Sánchez-Maldonado, Angelica Macauda, Antonio José Cabrera-Serrano, Hauke Thomsen, Murat Güler, Rob Ter Horst, Bethany Van Guelpen, Pavel Vodicka, Stefano Landi, Subhayan Chattopadhyay, Pelin Ünal, Lucía Ruiz-Durán, Delphine Casabonne, Hartmut Goldschmidt, Istemi Serin, María Carretero-Fernández, Elena Cabezudo, Fernando Reyes-Zurita, Alyssa I. Clay-Gilmour, Et. Al.

Faculty Publications

Monoclonal gammopathy of undetermined significance (MGUS) is a necessary precursor condition to multiple myeloma (MM). Given the role of autophagy in modulating MM risk, we investigated whether genetic variation in autophagy-related genes influences susceptibility to MGUS. We analyzed the association of 34,042 common autophagy-related single nucleotide polymorphisms (SNPs) with MGUS across six independent cohorts, five from Europe and one from North America, comprising 2317 MGUS cases and 282,358 controls. We also assessed their impact on immune parameters, including absolute counts of 91 blood-derived immune cell subsets and 103 circulating immunological proteins. Meta-analysis revealed a genome-wide significant association between the ULK4 …

Moderate-Temperature Hydrothermal Treatment Removes Detectable Dna And Antibiotic Resistance Genes From Municipal Sludge While Preserving Resource Value, R Sean Norman M.Sc., Ph.D., Mirza Isanovic, Gabrielle Kartzmark, Nicole Berge

Faculty Publications

Wastewater treatment plants (WWTPs) are key reservoirs of antibiotic resistance genes (ARGs), with municipal sludge containing high bacterial densities and diverse ARGs that may spread through land application. Hydrothermal treatment (HT) is a process that inactivates pathogens and stabilizes biomass, but its performance at moderate temperatures is less understood. We evaluated HT (100°C–250°C; 2–24 h) for degrading bacterial DNA and ARGs in dewatered municipal sludge. DNA was quantified by fluorometry, bacterial presence confirmed by 16S rRNA gene PCR, and ARGs profiled by qPCR targeting 84 clinically and environmentally relevant genes. HT up to 250°C produced modest carbon densification, high solids …

Moderate-Temperature Hydrothermal Treatment Removes Detectable Dna And Antibiotic Resistance Genes From Municipal Sludge While Preserving Resource Value, R. Sean Norman, Mirza Isanovic, Gabrielle Kartzmark, Nicole Berge

Faculty Publications

Wastewater treatment plants (WWTPs) are key reservoirs of antibiotic resistance genes (ARGs), with municipal sludge containing high bacterial densities and diverse ARGs that may spread through land application. Hydrothermal treatment (HT) is a process that inactivates pathogens and stabilizes biomass, but its performance at moderate temperatures is less understood. We evaluated HT (100°C–250°C; 2–24 h) for degrading bacterial DNA and ARGs in dewatered municipal sludge. DNA was quantified by fluorometry, bacterial presence confirmed by 16S rRNA gene PCR, and ARGs profiled by qPCR targeting 84 clinically and environmentally relevant genes. HT up to 250°C produced modest carbon densification, high solids …

Main-Chain Ion-Pair Polybenzimidazole Membranes Enabling Reduced-Temperature Ht-Pemfc Operation (Down To 120°C), Huina Lin, Brian C. Benicewicz

Faculty Publications

Proton exchange membrane (PEM) fuel cells are promising for clean and efficient energy conversion across diverse applications. High-temperature PEM fuel cells (HT-PEMFCs) using phosphoric acid (PA)-doped polybenzimidazole (PBI) can operate up to 200°C, but at lower temperatures, water-induced PA loss often leads to performance degradation and reduced durability. In this work, we present a new class of main-chain ion-pair PBI membranes by integrating the imidazolium-biphosphate ion-pair units directly into the PBI backbone. This design results in membranes with high acid content, stronger acid-polymer interactions and stabilized acid retention. In single-cell tests, the Im⁺-PBI15-3 wt.% exhibits peak power densities …

A Review Of Interaction Between Sleep Apnea And Apoe E4 On The Risk Of Dementia, Xiuhua Ding, Carol Watwood, Amit Patel, Krupa Hegde, Brooke Mahanna, Lindsey Escudero, Jean Neils-Strunjas Ph.D, Ccc-Slp

Faculty Publications

Dementia has a significant impact on individuals, families, communities, and the economy. Alzheimer’s disease (AD) accounts for 60–80% of dementia cases. The APOE e4 allele is well known as the primary genetic risk factor for AD and dementia. Studies have also shown that sleep apnea increases the risk of dementia. Some research further suggests a possible interaction between sleep apnea and the APOE in dementia development; however, this relationship remains unclear. The purpose of this study is to synthesize evidence from the existing literature and report findings on the relationship between APOE, sleep apnea, and dementia. A systematic search of …

Potential Impacts Of Climate Interventions On Marine Ecosystems, Kelsey E. Roberts, Tyler Rohr, Morgan R. Raven, Michael S. Diamond, Daniele Visioni, Ben Kravitz, Ryan Heneghan, Colleen M. Petrik, Daniele Bianchi, Kelly Ortega-Cisneros, Monica A. Morrison, Vanessa Van Heerden, Nicola A. Wiseman, Gouri Anil, Zachary J. Cannizzo, Marta Coll, Joshua Coupe, Ryan Freedman, Kristen Krumhardt, Lester Kwiatkowski, Nicole S. Lovenduski, Jessica Y. Luo, Holly C. Olivarez, Alan Robock, Jeroen Steenbeek, Cheryl S. Harrison

Faculty Publications

Rising global temperatures pose significant risks to marine ecosystems, biodiversity, and fisheries. Recent comprehensive assessments suggest that large-scale mitigation efforts to limit warming are falling short, and all feasible future climate projections, including those that represent optimistic emissions reductions, exceed the Paris Agreement's 1.5°C or 2° warming targets during this century. While avoiding further CO2 emissions remains the most effective way to prevent environmental destabilization, interest is growing in climate interventions—deliberate, large-scale manipulations of the environment aimed at reducing global warming. These include carbon dioxide removal (CDR) to reduce atmospheric CO2 concentrations over time, and solar radiation modification (SRM), which …

Characterization And Response To Exercise Training Of Hdl-Specific Phospholipid Efflux, Eric C. Leszcynski, Charles S. Schwartz, Kiani J.C. Jacobs, Prasun L. Dev, Sujoy Ghosh, Jeremy M. Robbins, Robert E. Gerszten, Anand Rohatgi, Timothy S. Collier, Robert J. Konard, Masaki Sato, Rafael Zubirán, Claude Bouchard, Edward B. Neufeld, Alan T. Remaley, Mark A. Sarzynski Facsm

Faculty Publications

The HDL-specific phospholipid efflux (HDL-SPE) assay is a novel cell-free measure of HDL function that is inversely associated with coronary artery disease. However, the effect of exercise training on HDL-SPE is unknown. The purpose of this study was to examine the effect of exercise training on HDL-SPE in a large, diverse cohort free of overt disease. Clinical and functional measures of HDL were taken before and after 20 weeks of endurance exercise training in 508 participants from the HERITAGE Family Study. Associations of HDL-SPE with HDL-related traits were examined using Pearson's correlations at baseline and following exercise training (significance: P …