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Influence Of Macrobenthos (Meretrix Meretrix Linnaeus) On Erosion-Accretion Processes In Intertidal Flats: A Case Study From A Cultivation Zone, B. Shi, P.D. Pratolongo, Y. Du, J. Li, S.L. Yang, J. Wu, K. Xu, Y.P. Wang Jan 2020

Influence Of Macrobenthos (Meretrix Meretrix Linnaeus) On Erosion-Accretion Processes In Intertidal Flats: A Case Study From A Cultivation Zone, B. Shi, P.D. Pratolongo, Y. Du, J. Li, S.L. Yang, J. Wu, K. Xu, Y.P. Wang

Faculty Publications

No abstract provided.

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Peer Influence On Conformity And Confidence In A Perceptual Judgment Task, Alen Hajnal, Jennifer Vonk, Virgil Zeigler-Hill Jan 2020

Peer Influence On Conformity And Confidence In A Perceptual Judgment Task, Alen Hajnal, Jennifer Vonk, Virgil Zeigler-Hill

Faculty Publications

© 2020 by authors. Undergraduate college students were presented with two arrays of dots varying in numerosity on a computer screen and asked to indicate if the arrays differed in number. They also rated their level of confidence in their responses. Trials varied in difficulty based on the size of the arrays. On half of the trials, participants were shown the ostensible responses of confederates to test the effect of peer influence on numerosity judgments and participant confidence. On the other half of the trials, participants received no information about the responses of the confederates to provide a measure of …

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Effects Of Facial Features And Styling Elements On Perceptions Of Competence, Warmth, And Hireability Of Male Professionals, Marc Fetscherin, Stacey Tantleff-Dunn, Arne Klumb Jan 2020

Effects Of Facial Features And Styling Elements On Perceptions Of Competence, Warmth, And Hireability Of Male Professionals, Marc Fetscherin, Stacey Tantleff-Dunn, Arne Klumb

Faculty Publications

Few studies investigated the effects of facial characteristics on stereotyping in the business context. Using a 2 (beard/no beard) x 2 (acne/no acne) x 2 (tie/no tie) x 2 (eyeglasses/no eyeglasses) between subjects’ design, two representative samples of 364 and 711 participants rated different stimuli of male subjects on dimensions of competence, warmth and hireability. Based on 4,215 observations, results show acne has a negative and eyeglasses a positive effect on both competence and warmth. Wearing a necktie has a positive effect on competence and a negative effect on warmth. Finally, beardedness has a negative effect on warmth. We also …

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Why States Must Consider Innocence Claims After Guilty Pleas, Colin Miller Jan 2020

Why States Must Consider Innocence Claims After Guilty Pleas, Colin Miller

Faculty Publications

The first DNA exoneree in this country was a man with a sub-70 IQ who pleaded guilty to avoid the death penalty, and a total of 139 out of 315 (44.1%) DNA and non-DNA exonerees in 2015 and 2016 had been convicted after guilty pleas. Nonetheless, a number of states have pleading defendant prohibitions in their postconviction statutes that preclude defendants who pleaded guilty from (1) seeking DNA testing; and/or (2) presenting freestanding claims of actual innocence based on non-DNA evidence. Existing Constitutional challenges to these statutes have been largely foreclosed by the Supreme Court’s opinion in District Attorney’s Office …

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Vitamin D3 Supplementation And Stress Fractures In High-Risk Collegiate Athletes - A Pilot Study, Kevin Williams, Christian Askew, Christopher Mazoue, Jeffrey Guy, Toni M. Torres-Mcgehee, J Benjamin Jackson Iii Jan 2020

Vitamin D3 Supplementation And Stress Fractures In High-Risk Collegiate Athletes - A Pilot Study, Kevin Williams, Christian Askew, Christopher Mazoue, Jeffrey Guy, Toni M. Torres-Mcgehee, J Benjamin Jackson Iii

Faculty Publications

INTRODUCTION: Vitamin D is paramount to bone health and little is known about vitamin D's role in the prevention of stress fractures in high-risk athletes. This study consists of a prospective, cross-sectional analysis accompanied by a retrospective review for control comparison of vitamin D3 supplementation in high-risk athletes. Our hypothesis is that supplemental vitamin D3 treatment will decrease the occurrence of stress fractures in high-risk collegiate athletes. MATERIALS AND METHODS: A total of 118 NCAA Division I athletes were recruited from 6 high-risk collegiate teams. Blood draws in August and February established baseline 25(OH)D levels. Subjects with serum 25(OH)D <30 ng/mL were supplemented with 50,000 IU of vitamin D3/week for 8 weeks. Treated subjects were re-tested to ensure serum 25(OH)D levels rose to sufficient status. All enrolled subjects were monitored for the development of stress fractures. A 5-year retrospective chart review of athletes from the same sports teams was conducted to determine the incidence of any reported stress fractures in the past. RESULTS: Prospective: 112 of the 118 enrolled subjects were tested in August. Sixty-one demonstrated vitamin D sufficiency (40.2 ng/mL ±8.28) and 51 were either insufficient or deficient (22.7 ng/mL ±4.89). Of the 118 enrolled subjects, 104 were tested in February. Fifty-six demonstrated vitamin D sufficiency (40.7 ng/mL ±9.47) and 48 were insufficient or deficient (21.6 ng/mL ±5.87). Two stress fractures were diagnosed amongst our cohort of 118 student athletes (1.69%). Retrospective: 34 stress fractures were diagnosed in 453 subjects from 01/2010-05/2015 (7.51%). Amongst our athletic teams, the cross-country team specifically demonstrated a statistically significant decrease in stress fracture incidence (p<0.05). We also found a statistically significant reduction in stress fracture incidence amongst the current overall cohort compared to our retrospective cohort (p<0.05). CONCLUSION: In our population, almost half of the tested athletes proved to be vitamin D deficient. Hypovitaminosis D was prevalent throughout the winter months compared with the summer. With vitamin D3 supplementation, the stress fracture rate in our overall cohort demonstrated a statistically significant decrease from 7.51% to 1.65% (p=0.009).

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Methods For Broad-Scale Plant Phenology Assessments Using Citizen Scientists’ Photographs, Vijay V. Barve, Laura Brenskelle, Daijiang Li, Brian J. Stucky, Narayani V. Barve, Maggie M. Hantak, Bryan S. Mclean, Daniel J. Paluh, Jessica A. Oswald, Michael W. Belitz, Ryan A. Folk, Robert P. Guralnick Jan 2020

Methods For Broad-Scale Plant Phenology Assessments Using Citizen Scientists’ Photographs, Vijay V. Barve, Laura Brenskelle, Daijiang Li, Brian J. Stucky, Narayani V. Barve, Maggie M. Hantak, Bryan S. Mclean, Daniel J. Paluh, Jessica A. Oswald, Michael W. Belitz, Ryan A. Folk, Robert P. Guralnick

Faculty Publications

© 2020 Barve et al. Applications in Plant Sciences is published by Wiley Periodicals, Inc. on behalf of the Botanical Society of America Premise: Citizen science platforms for sharing photographed digital vouchers, such as iNaturalist, are a promising source of phenology data, but methods and best practices for use have not been developed. Here we introduce methods using Yucca flowering phenology as a case study, because drivers of Yucca phenology are not well understood despite the need to synchronize flowering with obligate pollinators. There is also evidence of recent anomalous winter flowering events, but with unknown spatiotemporal extents. Methods: We …

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Impaired Purine Homeostasis Plays A Primary Role In Trimethoprim-Mediated Induction Of Virulence Genes In Burkholderia Thailandensis, Sudarshan S. Thapa, Anne Grove Jan 2020

Impaired Purine Homeostasis Plays A Primary Role In Trimethoprim-Mediated Induction Of Virulence Genes In Burkholderia Thailandensis, Sudarshan S. Thapa, Anne Grove

Faculty Publications

© 2020 John Wiley & Sons Ltd One of the most commonly prescribed antibiotics against Burkholderia infections is co-trimoxazole, a cocktail of trimethoprim and sulfamethoxazole. Trimethoprim elicits an upregulation of the mal gene cluster, which encodes proteins involved in synthesis of the cytotoxic polyketide malleilactone; trimethoprim does so by increasing expression of the malR gene, which encodes the activator MalR. We report that B. thailandensis grown on trimethoprim exhibited increased virulence against Caenorhabditis elegans. This enhanced virulence correlated with an increase in expression of the mal gene cluster. Notably, inhibition of xanthine dehydrogenase by addition of allopurinol led to similar …

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Modeling The Effects Of Trait-Mediated Dispersal On Coexistence Of Mutualists, James T. Cronin, Jerome Goddard, Amila Muthunayake, Ratnasingham Shivaji Jan 2020

Modeling The Effects Of Trait-Mediated Dispersal On Coexistence Of Mutualists, James T. Cronin, Jerome Goddard, Amila Muthunayake, Ratnasingham Shivaji

Faculty Publications

© 2020 the Author(s), licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) Even though mutualistic interactions are ubiquitous in nature, we are still far from making good predictions about the fate of mutualistic communities under threats such as habitat fragmentation and climate change. Fragmentation often causes declines in abundance of a species due to increased susceptibility to edge effects between remnant habitat patches and lower quality “matrix” surrounding these focal patches. It has been argued that ecological communities are replete with trait-mediated indirect effects, and that these effects …

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Modeling The Effects Of Density Dependent Emigration, Weak Allee Effects, And Matrix Hostility On Patch-Level Population Persistence, James T. Cronin, Nalin Fonseka, Jerome Goddard, Jackson Leonard, Ratnasingham Shivaji Jan 2020

Modeling The Effects Of Density Dependent Emigration, Weak Allee Effects, And Matrix Hostility On Patch-Level Population Persistence, James T. Cronin, Nalin Fonseka, Jerome Goddard, Jackson Leonard, Ratnasingham Shivaji

Faculty Publications

© 2020 the Author(s), licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) The relationship between conspecific density and the probability of emigrating from a patch can play an essential role in determining the population-dynamic consequences of an Allee effect. In this paper, we model a population that inside a patch is diffusing and growing according to a weak Allee effect per-capita growth rate, but the emigration probability is dependent on conspecific density. The habitat patch is one-dimensional and is surrounded by a tuneable hostile matrix. We consider five …

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Taxonomic Resolution Affects Host-Parasite Association Model Performance, Tad A. Dallas, Daniel J. Becker Jan 2020

Taxonomic Resolution Affects Host-Parasite Association Model Performance, Tad A. Dallas, Daniel J. Becker

Faculty Publications

© 2020 Georg Thieme Verlag. All rights reserved. Identifying the factors that structure host-parasite interactions is fundamental to understand the drivers of species distributions and to predict novel cross-species transmission events. More phylogenetically related host species tend to have more similar parasite associations, but parasite specificity may vary as a function of transmission mode, parasite taxonomy, or life history. Accordingly, analyses that attempt to infer host-parasite associations using combined data on different parasite groups may perform quite differently relative to analyses on each parasite subset. In essence, are more data always better when predicting host-parasite associations, or does parasite taxonomic …

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Behavioral, Morphological, And Ecological Trait Evolution In Two Clades Of New World Sparrows (Aimophila And Peucaea, Passerellidae), Carla Cicero, Nicholas A. Mason, Lauryn Benedict, James D. Rising Jan 2020

Behavioral, Morphological, And Ecological Trait Evolution In Two Clades Of New World Sparrows (Aimophila And Peucaea, Passerellidae), Carla Cicero, Nicholas A. Mason, Lauryn Benedict, James D. Rising

Faculty Publications

Copyright 2020 Cicero et al. The New World sparrows (Passerellidae) are a large, diverse group of songbirds that vary in morphology, behavior, and ecology. Thus, they are excellent for studying trait evolution in a phylogenetic framework. We examined lability versus conservatism in morphological and behavioral traits in two related clades of sparrows (Aimophila, Peucaea), and assessed whether habitat has played an important role in trait evolution. We first inferred a multi-locus phylogeny which we used to reconstruct ancestral states, and then quantified phylogenetic signal among morphological and behavioral traits in these clades and in New World sparrows more broadly. Behavioral …

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The Extended Specimen Network: A Strategy To Enhance Us Biodiversity Collections, Promote Research And Education, James Lendemer, Barbara Thiers, Anna K. Monfils, Jennifer Zaspel, Elizabeth R. Ellwood, Andrew Bentley, Katherine Levan, John Bates, David Jennings, Dori Contreras, Laura Lagomarsino, Paula Mabee, Linda S. Ford, Robert Guralnick, Robert E. Gropp, Marcy Revelez, Neil Cobb, Katja Seltmann, M. Catherine Aime Jan 2020

The Extended Specimen Network: A Strategy To Enhance Us Biodiversity Collections, Promote Research And Education, James Lendemer, Barbara Thiers, Anna K. Monfils, Jennifer Zaspel, Elizabeth R. Ellwood, Andrew Bentley, Katherine Levan, John Bates, David Jennings, Dori Contreras, Laura Lagomarsino, Paula Mabee, Linda S. Ford, Robert Guralnick, Robert E. Gropp, Marcy Revelez, Neil Cobb, Katja Seltmann, M. Catherine Aime

Faculty Publications

No abstract provided.

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Improving Natural Product Research Translation: From Source To Clinical Trial, Barbara C. Sorkin, Adam J. Kuszak, Gregory Bloss, Naomi K. Fukagawa, Freddie Ann Hoffman, Mahtab Jafari, Bruce Barrett, Paula N. Brown, Frederic D. Bushman, Steven J. Casper, Floyd H. Chilton, Christopher S. Coffey, Mario G. Ferruzzi, D. Craig Hopp, Mairead Kiely, Daniel Lakens, John B. Macmillan, David O. Meltzer, Marco Pahor, Jeffrey Paul, Kathleen Pritchett-Corning, Sara K. Quinney, Barbara Rehermann, Kenneth D.R. Setchell, Nisha S. Sipes, Jacqueline M. Stephens, D. Lansing Taylor, Hervé Tiriac, Michael A. Walters, Dan Xi, Giovanna Zappalá, Guido F. Pauli Jan 2020

Improving Natural Product Research Translation: From Source To Clinical Trial, Barbara C. Sorkin, Adam J. Kuszak, Gregory Bloss, Naomi K. Fukagawa, Freddie Ann Hoffman, Mahtab Jafari, Bruce Barrett, Paula N. Brown, Frederic D. Bushman, Steven J. Casper, Floyd H. Chilton, Christopher S. Coffey, Mario G. Ferruzzi, D. Craig Hopp, Mairead Kiely, Daniel Lakens, John B. Macmillan, David O. Meltzer, Marco Pahor, Jeffrey Paul, Kathleen Pritchett-Corning, Sara K. Quinney, Barbara Rehermann, Kenneth D.R. Setchell, Nisha S. Sipes, Jacqueline M. Stephens, D. Lansing Taylor, Hervé Tiriac, Michael A. Walters, Dan Xi, Giovanna Zappalá, Guido F. Pauli

Faculty Publications

© 2019 Federation of American Societies for Experimental Biology While great interest in health effects of natural product (NP) including dietary supplements and foods persists, promising preclinical NP research is not consistently translating into actionable clinical trial (CT) outcomes. Generally considered the gold standard for assessing safety and efficacy, CTs, especially phase III CTs, are costly and require rigorous planning to optimize the value of the information obtained. More effective bridging from NP research to CT was the goal of a September, 2018 transdisciplinary workshop. Participants emphasized that replicability and likelihood of successful translation depend on rigor in experimental design, …

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Novel Resistant Starch Type 4 Products Of Different Starch Origins, Production Methods, And Amounts Are Not Equally Fermented When Fed To Sprague-Dawley Rats, Diana B. Coulon, Ryan Page, Anne M. Raggio, Justin Guice, Brain Marx, Vishnupriya Gourineni, Maria L. Stewart, Michael J. Keenan Jan 2020

Novel Resistant Starch Type 4 Products Of Different Starch Origins, Production Methods, And Amounts Are Not Equally Fermented When Fed To Sprague-Dawley Rats, Diana B. Coulon, Ryan Page, Anne M. Raggio, Justin Guice, Brain Marx, Vishnupriya Gourineni, Maria L. Stewart, Michael J. Keenan

Faculty Publications

© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Scope: The possible mechanisms of production of four novel resistant starch type 4 (RS4) products for total cecal fermentation in an in vivo rodent model are evaluated. Methods and results: Forty weanling rats are randomly assigned to five groups (n = 8) for a 3-week study. Starches are the RS type 4 products, as 10% of weight of RS diets (RSA–RSD), and AMIOCA starch (100% amylopectin) comprises 53.6% weight of control (CON) and 43.6% weight of RS diets. The RS products vary by percent purity and origin (potato, corn, tapioca). At …

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The Landscape Of Accessible Chromatin In Bovine Oocytes And Early Embryos, Hao Ming, Jiangwen Sun, Rolando Pasquariello, Lauren Gatenby, Jason Herrick, Ye Yuan, Carlos Pinto, Kenneth R. Bondioli, Rebecca L. Krisher, Zongliang Jiang Jan 2020

The Landscape Of Accessible Chromatin In Bovine Oocytes And Early Embryos, Hao Ming, Jiangwen Sun, Rolando Pasquariello, Lauren Gatenby, Jason Herrick, Ye Yuan, Carlos Pinto, Kenneth R. Bondioli, Rebecca L. Krisher, Zongliang Jiang

Faculty Publications

© 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group. Chromatin reorganization governs the regulation of gene expression during preimplantation development. However, the landscape of chromatin dynamics in this period has not been explored in bovine. In this study, we constructed a genome-wide map of accessible chromatin in bovine oocytes and early embryos using an improved assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq) which revealed unique features of the accessible chromatin during bovine early embryo development. We found that chromatin accessibility is low in oocytes and 2-/4-cell embryos, followed by a significant increase in embryos during …

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Novel Resistant Starch Type 4 Products Of Different Starch Origins, Production Methods, And Amounts Are Not Equally Fermented When Fed To Sprague-Dawley Rats, Diana B. Coulon, Ryan Page, Anne M. Raggio, Justin Guice, Brain Marx, Vishnupriya Gourineni, Maria L. Stewart, Michael J. Keenan Jan 2020

Novel Resistant Starch Type 4 Products Of Different Starch Origins, Production Methods, And Amounts Are Not Equally Fermented When Fed To Sprague-Dawley Rats, Diana B. Coulon, Ryan Page, Anne M. Raggio, Justin Guice, Brain Marx, Vishnupriya Gourineni, Maria L. Stewart, Michael J. Keenan

Faculty Publications

© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Scope: The possible mechanisms of production of four novel resistant starch type 4 (RS4) products for total cecal fermentation in an in vivo rodent model are evaluated. Methods and results: Forty weanling rats are randomly assigned to five groups (n = 8) for a 3-week study. Starches are the RS type 4 products, as 10% of weight of RS diets (RSA–RSD), and AMIOCA starch (100% amylopectin) comprises 53.6% weight of control (CON) and 43.6% weight of RS diets. The RS products vary by percent purity and origin (potato, corn, tapioca). At …

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The Landscape Of Accessible Chromatin In Bovine Oocytes And Early Embryos, Hao Ming, Jiangwen Sun, Rolando Pasquariello, Lauren Gatenby, Jason Herrick, Ye Yuan, Carlos Pinto, Kenneth R. Bondioli, Rebecca L. Krisher, Zongliang Jiang Jan 2020

The Landscape Of Accessible Chromatin In Bovine Oocytes And Early Embryos, Hao Ming, Jiangwen Sun, Rolando Pasquariello, Lauren Gatenby, Jason Herrick, Ye Yuan, Carlos Pinto, Kenneth R. Bondioli, Rebecca L. Krisher, Zongliang Jiang

Faculty Publications

© 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group. Chromatin reorganization governs the regulation of gene expression during preimplantation development. However, the landscape of chromatin dynamics in this period has not been explored in bovine. In this study, we constructed a genome-wide map of accessible chromatin in bovine oocytes and early embryos using an improved assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq) which revealed unique features of the accessible chromatin during bovine early embryo development. We found that chromatin accessibility is low in oocytes and 2-/4-cell embryos, followed by a significant increase in embryos during …

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Phlebotomines (Diptera: Psychodidae) From A Urban Park Of Belém, Pará State, Northern Brazil And Potential Implications In The Transmission Of American Cutaneous Leishmaniasis, Yetsenia D.V. Sánchez Uzcátegui, Thiago Vasconcelos Dos Santos, Fernando T. Silveira, Patricia K.S. Ramos, Eduardo José M. Dos Santos, Marinete M. Póvoa, Lane Foil Jan 2020

Phlebotomines (Diptera: Psychodidae) From A Urban Park Of Belém, Pará State, Northern Brazil And Potential Implications In The Transmission Of American Cutaneous Leishmaniasis, Yetsenia D.V. Sánchez Uzcátegui, Thiago Vasconcelos Dos Santos, Fernando T. Silveira, Patricia K.S. Ramos, Eduardo José M. Dos Santos, Marinete M. Póvoa, Lane Foil

Faculty Publications

© 2019 The Author(s) 2019. Published by Oxford University Press on behalf of Entomological Society of America. In urban ecotourism parks, the life cycle of American cutaneous leishmaniasis (ACL) agents can remain established, where phlebotomines may comprise potential risks for visitors. The present study aimed to survey the phlebotomine fauna of a forest park 'Bosque Rodriques Alves-Jardim Botânico da Amazônia' (BRAJBA), in the urban area of Belém, Brazil. The park was monthly surveyed in 2018 using CDC light traps placed in ground and canopy strata. Leishmania spp. isolated from dissected females were characterized by polymerase chain reaction-restriction fragment length polymorphism …

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Tropism, Pathology, And Transmission Of Equine Parvovirus-Hepatitis, Joy Ellen Tomlinson, Mason Jager, Alyssa Struzyna, Melissa Laverack, Lisa Ann Fortier, Edward Dubovi, Lane D. Foil, Peter D. Burbelo, Thomas J. Divers, Gerlinde R. Van De Walle Jan 2020

Tropism, Pathology, And Transmission Of Equine Parvovirus-Hepatitis, Joy Ellen Tomlinson, Mason Jager, Alyssa Struzyna, Melissa Laverack, Lisa Ann Fortier, Edward Dubovi, Lane D. Foil, Peter D. Burbelo, Thomas J. Divers, Gerlinde R. Van De Walle

Faculty Publications

© 2020, © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd. Equine parvovirus-hepatitis (EqPV-H) has recently been associated with cases of Theiler's disease, a form of fulminant hepatic necrosis in horses. To assess whether EqPV-H is the cause of Theiler's disease, we first demonstrated hepatotropism by PCR on tissues from acutely infected horses. We then experimentally inoculated horses with EqPV-H and 8 of 10 horses developed hepatitis. One horse showed clinical signs of liver failure. The onset of hepatitis was temporally associated with seroconversion and …

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Response Of Liver Metabolic Pathways To Ketogenic Diet And Exercise Are Not Additive, Tai Yu Huang, Felicia R. Goldsmith, Scott E. Fuller, Jacob Simon, Heidi M. Batdorf, Matthew C. Scott, Nabil M. Essajee, John M. Brown, David H. Burk, Christopher D. Morrison, Susan J. Burke, J. Jason Collier, Robert C. Noland Jan 2020

Response Of Liver Metabolic Pathways To Ketogenic Diet And Exercise Are Not Additive, Tai Yu Huang, Felicia R. Goldsmith, Scott E. Fuller, Jacob Simon, Heidi M. Batdorf, Matthew C. Scott, Nabil M. Essajee, John M. Brown, David H. Burk, Christopher D. Morrison, Susan J. Burke, J. Jason Collier, Robert C. Noland

Faculty Publications

© Lippincott Williams & Wilkins. Purpose Studies suggest ketogenic diets (KD) produce favorable outcomes (health and exercise performance); however, most rodent studies have used a low-protein KD, which does not reflect the normal- to high-protein KD used by humans. Liver has an important role in ketoadaptation due to its involvement in gluconeogenesis and ketogenesis. This study was designed to test the hypothesis that exercise training (ExTr) while consuming a normal-protein KD (NPKD) would induce additive/synergistic responses in liver metabolic pathways. Methods Lean, healthy male C57BL/6J mice were fed a low-fat control diet (15.9% kcal protein, 11.9% kcal fat, 72.2% kcal …

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The Nagoya Protocol And The Legal Structure Of Global Biogenomic Research, Sam F. Halabi, Michelle Rourke, Gian Luca Burci, Rebecca Katz Jan 2020

The Nagoya Protocol And The Legal Structure Of Global Biogenomic Research, Sam F. Halabi, Michelle Rourke, Gian Luca Burci, Rebecca Katz

Faculty Publications

As life sciences technologies have advanced, so too has the potential for these international collaborations to lead to breakthrough medicines, enhance food security, and protect ecological systems. The linchpin of this progress is the development of high throughput genetic sequencing technologies. Researchers are now able to generate and compare large stretches of DNA - 1 million bases or more - from different sources quickly and inexpensively. Such comparisons can yield massive amounts of information about the role of inheritance in susceptibility to infection and illness as well as responses to environmental influences. In addition, the ability to sequence genomes more …

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Early Access To Unapproved Medicines In The United States And France, Erika Lietzan Jan 2020

Early Access To Unapproved Medicines In The United States And France, Erika Lietzan

Faculty Publications

In 2018, President Trump signed a federal "right to try" law, claiming that it would give desperately ill patients earlier access to unapproved medicines, by allowing the patient, doctor, and drug company to arrange for access without federal oversight. Critics of the law argued that it would not meaningfully increase access to experimental medicines, because federal oversight was not the obstacle in the first place. And they were correct. U.S. law already permitted companies to provide terminally ill patients with early access to unapproved medicines. The problem was instead that companies did not take advantage of this option. This Article …

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Use Of Multiple Stream Temperature Logger Models Can Alter Conclusions, Robin M. Rotman, Joanna B. Whittier, Jacob T. Westhoff, Craig P. Paukert Jan 2020

Use Of Multiple Stream Temperature Logger Models Can Alter Conclusions, Robin M. Rotman, Joanna B. Whittier, Jacob T. Westhoff, Craig P. Paukert

Faculty Publications

Remote temperature loggers are often used to measure water temperatures for ecological studies and by regulatory agencies to determine whether water quality standards are being maintained. Equipment specifications are often given a cursory review in the methods; however, the effect of temperature logger model is rarely addressed in the discussion. In a laboratory environment, we compared measurements from three models of temperature loggers at 5 to 40 °C to better understand the utility of these devices. Mean water temperatures recorded by logger models differed statistically even for those with similar accuracy specifications, but were still within manufacturer accuracy specifications. Maximum …

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Framework For A Community Health Observing System For The Gulf Of Mexico Region: Preparing For Future Disasters, P Sandifer, L Knapp, M Lichtveld, R Manley, P Sandifer, R Caffey, D Cochran, T Collier, K Ebi, L Engel, J Farrington, M Finucane, C Hale, D Halpern, E Harville, L Hart, Y Hswen, B Kirkpatrick, B Mcewen, G Morris, R Orbach, L Palinkas, M Partyka, D Porter, G Prather, T Rowles, G Scott, T Seeman, H Solo-Gabriele, E Svendsen, T Tincher, J Trtanj, A H. Walker, R Yehuda Jan 2020

Framework For A Community Health Observing System For The Gulf Of Mexico Region: Preparing For Future Disasters, P Sandifer, L Knapp, M Lichtveld, R Manley, P Sandifer, R Caffey, D Cochran, T Collier, K Ebi, L Engel, J Farrington, M Finucane, C Hale, D Halpern, E Harville, L Hart, Y Hswen, B Kirkpatrick, B Mcewen, G Morris, R Orbach, L Palinkas, M Partyka, D Porter, G Prather, T Rowles, G Scott, T Seeman, H Solo-Gabriele, E Svendsen, T Tincher, J Trtanj, A H. Walker, R Yehuda

Faculty Publications

The Gulf of Mexico (GoM) region is prone to disasters, including recurrent oil spills, hurricanes, floods, industrial accidents, harmful algal blooms, and the current COVID-19 pandemic. The GoM and other regions of the U.S. lack sufficient baseline health information to identify, attribute, mitigate, and facilitate prevention of major health effects of disasters. Developing capacity to assess adverse human health consequences of future disasters requires establishment of a comprehensive, sustained community health observing system, similar to the extensive and well-established environmental observing systems. We propose a system that combines six levels of health data domains, beginning with three existing, national surveys …

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Who’S Afraid Of Ebola? Epidemic Fires And Locative Fears In The Information Age, W. Shrum, J. Aggrey, A. Campos, J. Pamplona Da Costa, J. Joseph, P. Kreimer, R. Kroeger, L. Medina, P. Miller, A. Palackal, A. Pandal De La Peza, A. Traore Jan 2020

Who’S Afraid Of Ebola? Epidemic Fires And Locative Fears In The Information Age, W. Shrum, J. Aggrey, A. Campos, J. Pamplona Da Costa, J. Joseph, P. Kreimer, R. Kroeger, L. Medina, P. Miller, A. Palackal, A. Pandal De La Peza, A. Traore

Faculty Publications

Epidemics have traditionally been viewed as the widespread occurrence of infectious disease within a community, or a sudden increase above what is typical. But modern epidemics are both more and less than the diffusion of viral entities. We argue that epidemics are 'fire objects', using a term coined by Law and Singleton: They generate locative fears through encounters that focus attention on entities that are unknown or imprecisely known, transforming spaces and humans into indeterminate dangers, alternating appearance and absence. The Ebola epidemic of 2014 had more complex impacts than the number of infections would suggest. We employ multi-sited qualitative …

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Artificial Intelligence And Covid-19: Deep Learning Approaches For Diagnosis And Treatment, M. B. Jamshidi, A. Lalbakhsh, J. Talla, Z. Peroutka, F. Hadjilooei, P Lalbakhsh, M. Jamshidi, L. La Spada, M. Mirmozafari, M. Dehghani, A. Sabet, Sa. Roshani, So. Roshani, N. Bayat-Makou, B. Mohamadzade, Z. Malek, A. Jamshidi, S. Kiani, H. Hashemi-Dezaki, W. Mohyuddin Jan 2020

Artificial Intelligence And Covid-19: Deep Learning Approaches For Diagnosis And Treatment, M. B. Jamshidi, A. Lalbakhsh, J. Talla, Z. Peroutka, F. Hadjilooei, P Lalbakhsh, M. Jamshidi, L. La Spada, M. Mirmozafari, M. Dehghani, A. Sabet, Sa. Roshani, So. Roshani, N. Bayat-Makou, B. Mohamadzade, Z. Malek, A. Jamshidi, S. Kiani, H. Hashemi-Dezaki, W. Mohyuddin

Faculty Publications

COVID-19 outbreak has put the whole world in an unprecedented difficult situation bringing life around the world to a frightening halt and claiming thousands of lives. Due to COVID-19 & x2019;s spread in 212 countries and territories and increasing numbers of infected cases and death tolls mounting to 5,212,172 and 334,915 (as of May 22 2020), it remains a real threat to the public health system. This paper renders a response to combat the virus through Artificial Intelligence (AI). Some Deep Learning (DL) methods have been illustrated to reach this goal, including Generative Adversarial Networks (GANs), Extreme Learning Machine (ELM), …

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Small Molecule Inhibitors Of The Bfrb-Bfd Interaction Decrease Pseudomonas Aeruginosa Fitness And Potentiate Fluoroquinolone Activity, Achala N.D.Punchi Hewage, Huili Yao, Baskar Nammalwar, Krishna Kumar Gnanasekaran, Scott Lovell, Richard A. Bunce, Kate Eshelman, Sahishna M. Phaniraj, Molly M. Lee, Blake R. Peterson, Kevin P. Battaile, Allen B. Reitz, Mario Rivera Jan 2020

Small Molecule Inhibitors Of The Bfrb-Bfd Interaction Decrease Pseudomonas Aeruginosa Fitness And Potentiate Fluoroquinolone Activity, Achala N.D.Punchi Hewage, Huili Yao, Baskar Nammalwar, Krishna Kumar Gnanasekaran, Scott Lovell, Richard A. Bunce, Kate Eshelman, Sahishna M. Phaniraj, Molly M. Lee, Blake R. Peterson, Kevin P. Battaile, Allen B. Reitz, Mario Rivera

Faculty Publications

© 2019 American Chemical Society. All rights reserved. The iron storage protein bacterioferritin (BfrB) is central to bacterial iron homeostasis. The mobilization of iron from BfrB, which requires binding by a cognate ferredoxin (Bfd), is essential to the regulation of cytosolic iron levels in P. aeruginosa. This paper describes the structure-guided development of small molecule inhibitors of the BfrB-Bfd protein-protein interaction. The process was initiated by screening a fragment library and followed by obtaining the structure of a fragment hit bound to BfrB. The structural insights were used to develop a series of 4-(benzylamino)- A nd 4-((3-phenylpropyl)amino)-isoindoline-1,3-dione analogs that selectively …

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Molecular Responses To Freshwater Limitation In The Mangrove Tree Avicennia Germinans (Acanthaceae), Mariana Vargas Cruz, Gustavo Maruyama Mori, Dong Ha Oh, Maheshi Dassanayake, Maria Imaculada Zucchi, Rafael Silva Oliveira, Anete Pereira De Souza Jan 2020

Molecular Responses To Freshwater Limitation In The Mangrove Tree Avicennia Germinans (Acanthaceae), Mariana Vargas Cruz, Gustavo Maruyama Mori, Dong Ha Oh, Maheshi Dassanayake, Maria Imaculada Zucchi, Rafael Silva Oliveira, Anete Pereira De Souza

Faculty Publications

© 2019 John Wiley & Sons Ltd Environmental variation along the geographical space can shape populations by natural selection. In the context of global warming and changing precipitation regimes, it is crucial to understand the role of environmental heterogeneity in tropical trees adaptation, given their disproportional contribution to water and carbon biogeochemical cycles. Here, we investigated how heterogeneity in freshwater availability along tropical wetlands has influenced molecular variations of the black mangrove (Avicennia germinans). A total of 57 trees were sampled at seven sites differing markedly in precipitation regime and riverine freshwater inputs. Using 2,297 genome-wide single nucleotide polymorphic markers, …

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Large-Scale Mass Wasting On The Miocene Continental Margin Of Western India, Sarah K. Dailey, Peter D. Clift, Denise K. Kulhanek, Jerzy Blusztajn, Claire M. Routledge, Gérôme Calvès, Paul O'Sullivan, Tara N. Jonell, Dhananjai K. Pandey, Sergio Andò, Giovanni Coletti, Peng Zhou, Yuting Li, Nikki E. Neubeck, James A.P. Bendle, Sophia Aharonovich, Elizabeth M. Griffith, Gundiga P. Gurumurthy, Annette Hahn, Masao Iwai, Boo Keun Khim, Anil Kumar, A. Ganesh Kumar, Hannah M. Liddy, Huayu Lu, Mitchell W. Lyle, Ravi Mishra, Tallavajhala Radhakrishna, Rajeev Saraswat, Rakesh Saxena, Giancarlo Scardia, Girish K. Sharma, Arun D. Singh Jan 2020

Large-Scale Mass Wasting On The Miocene Continental Margin Of Western India, Sarah K. Dailey, Peter D. Clift, Denise K. Kulhanek, Jerzy Blusztajn, Claire M. Routledge, Gérôme Calvès, Paul O'Sullivan, Tara N. Jonell, Dhananjai K. Pandey, Sergio Andò, Giovanni Coletti, Peng Zhou, Yuting Li, Nikki E. Neubeck, James A.P. Bendle, Sophia Aharonovich, Elizabeth M. Griffith, Gundiga P. Gurumurthy, Annette Hahn, Masao Iwai, Boo Keun Khim, Anil Kumar, A. Ganesh Kumar, Hannah M. Liddy, Huayu Lu, Mitchell W. Lyle, Ravi Mishra, Tallavajhala Radhakrishna, Rajeev Saraswat, Rakesh Saxena, Giancarlo Scardia, Girish K. Sharma, Arun D. Singh

Faculty Publications

© 2019 Geological Society of America. A giant mass-transport complex was recently discovered in the eastern Arabian Sea, exceeding in volume all but one other known complex on passive margins worldwide. The complex, named the Nataraja Slide, was drilled by International Ocean Discovery Program (IODP) Expedition 355 in two locations where it is ~300 m (Site U1456) and ~200 m thick (Site U1457). The top of this mass-transport complex is defined by the presence of both reworked microfossil assemblages and deformation structures, such as folding and faulting. The deposit consists of two main phases of mass wasting, each consisting of …

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The Role Of Functional Strategies In Global Plant Distribution, Huixuan Liao, Daijiang Li, Ting Zhou, Bei Huang, Haijie Zhang, Baoming Chen, Shaolin Peng Jan 2020

The Role Of Functional Strategies In Global Plant Distribution, Huixuan Liao, Daijiang Li, Ting Zhou, Bei Huang, Haijie Zhang, Baoming Chen, Shaolin Peng

Faculty Publications

© 2020 The Authors. Ecography published by John Wiley & Sons Ltd on behalf of Nordic Society Oikos Understanding the determinants of species distributions is a central topic in ecology. Competition, stress tolerance and colonization, respectively represented by Grime's competitor (C), stress-tolerator (S) and ruderal (R) schemes, are three important functions that interactively influence plant distributions. In this study, we compiled a dataset of 2645 vascular plant species to explore the roles of the CSR strategies in global plant distribution. We analyzed the associations between the CSR scores and species range size with phylogenetic generalized least square (PGLS) models and …

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