Digital Commons Network^™

Sex And Gender In Research On Healthcare Workers In Conflict Settings: A Scoping Review, Dana A. Halwani, Diana Mikati, Layal Hneiny

Faculty Publications

The occupational health literature has established that sex and gender are associated with all dimensions of the workplace. Sex and/or gender (sex/gender) factors play an important role in shaping the experiences, exposures, and health outcomes of male and female healthcare providers working in war and conflict settings. This study aims to (1) assess how sex/gender is considered in the occupational health literature on healthcare workers in conflict settings, and (2) identify the gaps in incorporating sex/gender concepts in this literature. A scoping review was carried out and nine electronic databases were searched using a comprehensive search strategy. Two reviewers screened …

Cooperative Policing Behaviour Regulates Reproductive Division Of Labour In A Termite, Qian Sun, Jordan D. Hampton, Austin Merchant, Kenneth F. Haynes, Xuguo Zhou

Faculty Publications

Reproductive conflicts are common in insect societies where helping castes retain reproductive potential. One of the mechanisms regulating these conflicts is policing, a coercive behaviour that reduces direct reproduction by other individuals. In eusocial Hymenoptera (ants, bees and wasps), workers or the queen act aggressively towards fertile workers, or destroy their eggs. In many termite species (order Blattodea), upon the death of the primary queen and king, workers and nymphs can differentiate into neotenic reproductives and inherit the breeding position. During this process, competition among neotenics is inevitable, but how this conflict is resolved remains unclear. Here, we report a …

Father-Adolescent Relationship Closeness: A Path Analysis Of Family Factor Associates With Father-Adolescent Engagement And Relationship Quality, Mark H. Trahan, Richard H. Morely, Kevin Shafer

Faculty Publications

Father-adolescent child relationship quality has been identified as key to adolescent health outcomes. While factors have previously been identified associated with father-adolescent closeness, a comprehensive model of understanding the influence of these factors is needed. Using cross-sectional data from the Study of Contemporary Fatherhood (SCF), this analysis of father-adolescent relationship closeness evaluated responses of nine hundred (N = 900) father surveys to investigate historical factors, including own father relationship quality, biological fathering, family transitions, and ACEs along with current factors, including co-parenting, depression, parenting stress, knowledge of adolescent, warmth, and engagement, on father-adolescent relationship closeness. Path analysis results indicate that …

A Highly Elastic And Fatigue-Resistant Natural Protein-Reinforced Hydrogel Electrolyte For Reversible-Compressible Quasi-Solid-State Supercapacitors, Jingya Nan, Gaitong Zhang, Tianyu Zhu, Zhongkai Wang, Lijun Wang, Hongsheng Wang, Fuxiang Chu, Chunpeng Wang, Chuanbing Tang

Faculty Publications

Compressible solid-state supercapacitors are emerging as promising power sources for next-generation flexible electronics with enhanced safety and mechanical integrity. Highly elastic and compressible solid electrolytes are in great demand to achieve reversible compressibility and excellent capacitive stability of these supercapacitor devices. Here, a lithium ion-conducting hydrogel electrolyte by integrating natural protein nanoparticles into polyacrylamide network is reported. Due to the synergistic effect of natural protein nanoparticles and polyacrylamide chains, the obtained hydrogel shows remarkable elasticity, high compressibility, and fatigue resistance properties. More significantly, the supercapacitor device based on this hydrogel electrolyte exhibits reversible compressibility under multiple cyclic compressions, working well …

The Robustness Of Reciprocity: Experimental Evidence That Each Form Of Reciprocity Is Robust To The Presence Of Other Forms Of Reciprocity, David Melamed, Brent Simpson, Jered Abernathy

Faculty Publications

Prosocial behavior is paradoxical because it often entails a cost to one’s own welfare to benefit others. Theoretical models suggest that prosociality is driven by several forms of reciprocity. Although we know a great deal about how each of these forms operates in isolation, they are rarely isolated in the real world. Rather, the topological features of human social networks are such that people are often confronted with multiple types of reciprocity simultaneously. Does our current understanding of human prosociality break down if we account for the fact that the various forms of reciprocity tend to co-occur in nature? Results …

Heavy Metals In The Arctic: Distribution And Enrichment Of Five Metals In Alaskan Soils, Clarice R. Perryman, Jochen Wirsing, Kathryn A. Bennett, Owen Brennick, Apryl L. Perry, Nicole Williamson, Jessica G. Ernakovich

Faculty Publications

Metal contamination of food and water resources is a known public health issue in Arctic and sub-Arctic communities due to the proximity of many communities to mining and drilling sites. In addition, permafrost thaw may release heavy metals sequestered in previously frozen soils, potentially contaminating food and water resources by increasing the concentration of metals in freshwater, plants, and wildlife. Here we assess the enrichment of selected heavy metals in Alaskan soils by synthesizing publicly available data of soil metal concentrations. We analyzed data of soil concentrations of arsenic, chromium, mercury, nickel, and lead from over 1,000 samples available through …

In Vitro And In Vivo Characterization Of Potent Antileishmanial Methionine Aminopeptidase 1 Inhibitors, Felipe Rodriguez, Sarah F. John, Eva Iniguez, Sebastian Montalvo, Karina Michael, Lyndsey White, Dong Liang, Omonike A. Olaleye, Rosa A. Maldonado

Faculty Publications

Leishmania major is the causative agent of cutaneous leishmaniasis (CL). No human vaccine is available for CL, and current drug regimens present several drawbacks, such as emerging resistance, severe toxicity, medium effectiveness, and/or high cost. Thus, the need for better treatment options against CL is a priority. In the present study, we validate the enzyme methionine aminopeptidase 1 of L. major (MetAP1Lm), a metalloprotease that catalyzes the removal of N-terminal methionine from peptides and proteins, as a chemotherapeutic target against CL infection. The in vitro antileishmanial activities of eight novel MetAP1 inhibitors (OJT001 to OJT008) were investigated. Three compounds, OJT006, …

Evidence Of Pathogen-Induced Immunogenetic Selection Across The Large Geographic Range Of A Wild Seabird, Hila Levy, Stephen R. Fiddaman, Julianna A. Vianna, Daly Noll, Gemma Clucas, Jasmine K. H. Sidhu, Michael J. Polito, Charles A. Bost, Richard A. Phillips, Sarah Crofts, Gary D. Miller, Pierre Pistorius, Francesco Bonnadonna, Celine Le Bohec, Andres Barbosa, Phil Trathan, Andrea Raya Rey, Laurent A. F. Frantz, Tom Hart, Adrian L. Smith

Faculty Publications

Over evolutionary time, pathogen challenge shapes the immunepheno type of the host to better respond to an incipient threat. The extent and direction of this selection pressure depend on the local pathogen composition, which is in turn determined by biotic and abiotic features of the environment. However, little is known about adaptation to local pathogen threats in wild animals. The Gentoo penguin (Pygoscelis papua) is a species complex that lends itself to the study of immune adaptation because of its circumpolar distribution over a large latitudinal range, with little or no admixture between ''different clades. Inthis study, we examine the …

Effects Of A Tropical Cyclone On Salt Marsh Insect Communities And Post-Cyclone Reassembly Processes, Xuan Chen, Benjamin J. Adams, William J. Platt, Linda M. Hooper-Bùi

Faculty Publications

© 2020 The Authors. Ecography published by John Wiley & Sons Ltd on behalf of Nordic Society Oikos Concepts regarding effects of recurrent natural disturbances and subsequent responses of communities are central to ecology and conservation biology. Tropical cyclones constitute major disturbances producing direct effects (damage, mortality) in many coastal communities worldwide. Subsequent reassembly involves changes in composition and abundance for which the underlying mechanisms (deterministic and stochastic processes) are still not clear, especially for mobile organisms. We examined tropical cyclone-induced changes in composition and reassembly of entire insect communities in 16 Louisiana coastal salt marshes before and after Hurricane …

Altered Gut Microbiota In Infants Is Associated With Respiratory Syncytial Virus Disease Severity, Jeffrey N. Harding, David Siefker, Luan Vu, Dahui You, John Devincenzo, J. F. Pierre, Stephania A. Cormier

Faculty Publications

© 2020 The Author(s). Background: Respiratory syncytial virus (RSV) is the number one cause of lower respiratory tract infections in infants. There are still no vaccines or specific antiviral therapies against RSV, mainly due to the inadequate understanding of RSV pathogenesis. Recent data suggest a role for gut microbiota community structure in determining RSV disease severity. Our objective was to determine the gut microbial profile associated with severe RSV patients, which could be used to help identify at-risk patients and develop therapeutically protective microbial assemblages that may stimulate immuno-protection. Results: We enrolled 95 infants from Le Bonheur during the 2014 …

The Association Between Phosphodiesterase-5 Inhibitors And Colorectal Cancer In A National Cohort Of Patients, S. Scott Sutton, Joseph Magagnoli, Tammy H. Cummings, James W. Hardin

Faculty Publications

INTRODUCTION: To examine the association between phosphodiesterase-5 (PDE-5) inhibitor use and incidence of colorectal cancer among patients with erectile dysfunction treated in the Veterans Affairs (VA) Healthcare System. METHODS: A retrospective cohort study using the Veterans Affairs Informatics and Computing Infrastructure was conducted, with data spanning January 2001-December 2016. Patients were followed up from index until (i) the first diagnosis of colorectal cancer, (ii) death, or (iii) the end of study period. Statistical analyses evaluated demographics and baseline characteristics between cohorts (PDE-5 exposed or not) and the effect of additional dosages of each specific PDE-5 inhibitor using adjusted multivariate Cox …

A Simple Index To Quantify And Compare The Magnitude Of Intraspecific Geographic Plumage Colour Variation In Typical Antbirds (Aves: Passeriformes: Thamnophilidae), R S. Marcondes, R T. Brumfield

Faculty Publications

Intraspecific geographic phenotypic variation is a crucial theme in evolutionary biology. Comparing its magnitude across species can provide insights into its ecological and genetic correlates. Here, we developed an index, which we dub the V index, to quantify intraspecific plumage colour variation in typical antbirds (Thamnophilidae), a family which has long interested ornithologists due to a high prevalence of intraspecific variation. The V index is based on a bivariate colour space defined by brightness and redness. Its value for each species equals the mean area occupied by each of its subspecies in that colour space, divided by the area of …

Identification Of Light Sources Using Machine Learning, Chenglong You, Mario A. Quiroz-Juárez, Aidan Lambert, Narayan Bhusal, Chao Dong, Armando Perez-Leija, Amir Javaid, Roberto De J. León-Montiel, Omar S. Magaña-Loaiza

Faculty Publications

The identification of light sources represents a task of utmost importance for the development of multiple photonic technologies. Over the last decades, the identification of light sources as diverse as sunlight, laser radiation, and molecule fluorescence has relied on the collection of photon statistics or the implementation of quantum state tomography. In general, this task requires an extensive number of measurements to unveil the characteristic statistical fluctuations and correlation properties of light, particularly in the low-photon flux regime. In this article, we exploit the self-learning features of artificial neural networks and the naive Bayes classifier to dramatically reduce the number …

A Noble-Transition Alloy Excels At Hot-Carrier Generation In The Near Infrared, Sara K.F. Stofela, Orhan Kizilkaya, Benjamin T. Diroll, Tiago R. Leite, Mohammad M. Taheri, Daniel E. Willis, Jason B. Baxter, William A. Shelton, Phillip T. Sprunger, Kevin M. Mcpeak

Faculty Publications

Above-equilibrium “hot”-carrier generation in metals is a promising route to convert photons into electrical charge for efficient near-infrared optoelectronics. However, metals that offer both hot-carrier generation in the near-infrared and sufficient carrier lifetimes remain elusive. Alloys can offer emergent properties and new design strategies compared to pure metals. Here, it is shown that a noble-transition alloy, AuxPd1−x, outperforms its constituent metals concerning generation and lifetime of hot carriers when excited in the near-infrared. At optical fiber wavelengths (e.g., 1550 nm), Au50Pd50 provides a 20-fold increase in the number of ≈0.8 eV hot holes, compared to Au, and a threefold increase …

Fine Structure Of Angular Distribution Of X-Ray Transition Radiation From Multilayered Radiator In Geant4, A. A. Savchenko, A. A. Tishchenko, D. Yu Sergeeva, N. Belyaev, M. Cherry, F. Dachs, S. Doronin, K. Filippov, P. Fusco, F. Gargano, S. Konovalov, F. Loparco, V. Mascagna, M. N. Mazziotta, S. Nechaeva, D. Ponomarenko, A. Romaniouk, E. J. Schioppa, S. Smirnov, Y. Smirnov, M. Soldani, P. Spinelli, M. N. Strikhanov, P. Teterin, V. O. Tikhomirov, K. Vorobev, K. Zhukov

Faculty Publications

The present version of the Transition Radiation (TR) simulation module implemented in the Geant4 toolkit describes very well experimental data for the TR energy distribution; however, it does not allow reproducing the details of angular distribution at small angles. In order to solve this problem, corrections to the existing x-ray TR module in Geant4 are proposed. With these corrections, the results of the simulations are in a good agreement with the angular TR distributions predicted by theory and obtained in the test beam measurements using a 480 um Si pixel detector and Mylar radiator.

Biomolecular Complex Viewed By Dynamic Nuclear Polarization Solid-State Nmr Spectroscopy, Arnab Chakraborty, Fabien Deligey, Jenny Quach, Frederic Mentink-Vigier, Ping Wang, Tuo Wang

Faculty Publications

© 2020 Portland Press Ltd. All rights reserved. Solid-state nuclear magnetic resonance (ssNMR) is an indispensable tool for elucidating the structure and dynamics of insoluble and non-crystalline biomolecules. The recent advances in the sensitivity-enhancing technique magic-angle spinning dynamic nuclear polarization (MAS-DNP) have substantially expanded the territory of ssNMR investigations and enabled the detection of polymer interfaces in a cellular environment. This article highlights the emerging MAS-DNP approaches and their applications to the analysis of biomolecular composites and intact cells to determine the folding pathway and ligand binding of proteins, the structural polymorphism of low-populated biopolymers, as well as the physical …

Solid-State Nmr Of Plant And Fungal Cell Walls: A Critical Review, Wancheng Zhao, Liyanage D. Fernando, Alex Kirui, Fabien Deligey, Tuo Wang

Faculty Publications

© 2020 Elsevier Inc. The cell walls of plants and microbes are a central source for bio-renewable energy and the major targets of antibiotics and antifungal agents. It is highly challenging to determine the molecular structure of complex carbohydrates, protein and lignin, and their supramolecular assembly in intact cell walls. This article selectively highlights the recent breakthroughs that employ 13C/15N solid-state NMR techniques to elucidate the architecture of fungal cell walls in Aspergillus fumigatus and the primary and secondary cell walls in a large variety of plant species such as Arabidopsis, Brachypodium, maize, and spruce. Built upon these pioneering studies, …

Reduction Of Phakopsora Pachyrhizi Infection On Soybean Through Host- And Spray-Induced Gene Silencing, Dongfang Hu, Zhi Yuan Chen, Chunquan Zhang, Mala Ganiger

Faculty Publications

Asian soybean rust (ASR), caused by the obligate fungal pathogen Phakopsora pachyrhizi, often leads to significant yield losses and can only be managed through fungicide applications currently. In the present study, eight urediniospore germination or appressorium formation induced P. pachyrhizi genes were investigated for their feasibility to suppress ASR through a bean pod mottle virus (BPMV)-based host-induced gene silencing (HIGS) strategy. Soybean plants expressing three of these modified BPMV vectors suppressed the expression of their corresponding target gene by 45%–80%, fungal biomass accumulation by 58%–80%, and significantly reduced ASR symptom development in soybean leaves after the plants were inoculated with …

A Note On Species Richness And The Variance Of Epidemic Severity, Peter Shaffery, Bret D. Elderd, Vanja Dukic

Faculty Publications

© 2020, Springer-Verlag GmbH Germany, part of Springer Nature. The commonly observed negative correlation between the number of species in an ecological community and disease risk, typically referred to as “the dilution effect”, has received a substantial amount of attention over the past decade. Attempts to test this relationship experimentally have revealed that, in addition to the mean disease risk decreasing with species number, so too does the variance of disease risk. This is referred to as the “variance reduction effect”, and has received relatively little attention in the disease-diversity literature. Here, we set out to clarify and quantify some …

Multiscale-Spectral Gfem And Optimal Oversampling, Ivo Babuška, Robert Lipton, Paul Sinz, Michael Stuebner

Faculty Publications

In this work we address the Multiscale Spectral Generalized Finite Element Method (MS-GFEM) developed in Babuška and Lipton (2011). We outline the numerical implementation of this method and present simulations that demonstrate contrast independent exponential convergence of MS-GFEM solutions. We introduce strategies to reduce the computational cost of generating the optimal oversampled local approximating spaces used here. These strategies retain accuracy while reducing the computational work necessary to generate local bases. Motivated by oversampling we develop a nearly optimal local basis based on a partition of unity on the boundary and the associated A-harmonic extensions.

Projecting Stand Survival And Basal Area Based On A Self-Thinning Model For Chinese Fir Plantations, Xiongqing Zhang, Quang V. Cao, Hanchen Wang, Aiguo Duan, Jianguo Zhang

Faculty Publications

The self-thinning rule has played a critical role in controlling stand stocking and modeling stand development in forest stands. Chinese fir (Cunninghamia lanceolata) is a native and fast-growing tree species used for timber production and is widely grown in southern China. Effective management of this important tree species requires accurate and reasonable predictions of stand growth and survival. Remeasured data from 48 plots distributed in Fujian, Jiangxi, Guangxi, and Sichuan provinces were used to develop models to predict stand survival and basal area based on the self-thinning trajectories. These trajectories were constructed using a self-thinning slope of -1.605, as suggested …

How Should Non-Probate Transfers Matter In Intestacy?, Mary Louise Fellows, E. Gary Spitko

Faculty Publications

Current intestacy laws inadequately meet the needs of intestates. This study demonstrates that the new heir reform increases the likelihood of promoting intestates’ donative intent in a growing number of twenty-first century familial situations.

Reflections On Covid-19, Insurance, Business Interruption, Systemic Risk, And The Future, Robert H. Jerry Ii

Faculty Publications

The COVID-19 pandemic is a major loss event for the insurance industry. This chapter begins with an overview of the pandemic’s most significant insurance implications. Because business interruption has been the most prominently discussed of these impacts, the second part of this chapter takes a closer look at business interruption insurance. This part describes how markets for this coverage are structured in the U.S., and then undertakes a detailed analysis of one of the most common business interruption policy forms, demonstrating that some aspects of this form, insofar as pandemic-caused business interruption is concerned, were not drafted with utmost precision. …

Recent Advances In Stimuli-Responsive Drug Release And Targeting Concepts Using Mesoporous Silica Nanoparticles, Ghada G. Abdo, Moustafa M. Zagho, Ashraf Khalil

Faculty Publications

Being a developed and promising approach, nanotechnology has attracted a lot of attention in biomedical and pharmaceutical therapy applications. Among nanostructured materials, mesoporous silica nanoparticles (MSNs) are effectively used as nanocarriers for drug delivery systems. MSNs can be tailored-designed by different synthetic techniques. Their morphological characteristics dictate the type of application of such materials. Recently, polymer-based materials have been employed to functionalize the MSNs surface. These modified nanocarriers are loaded with the drug and can unload their “cargo” upon exposure to either endogenous or exogenous types of stimuli. In this study, different targeting concepts, including passive, active, vascular, nuclear, and …

The Importance Of Infrequent, High-Intensity Rainfall Events For Longleaf Pine (Pinus Palustris Mill.) Radial Growth And Implications For Dendroclimatic Research, Tyler J. Mitchell, Paul A. Knapp, Thomas W. Patterson

Faculty Publications

Tree-ring based precipitation reconstructions are beneficial in placing interannual variability in an historical context. However, absent specificity on what is being modeled (e.g., event type or rainfall intensity), similar rainfall totals inferred from reconstructions between different years imply similar conditions. Consequently, variability in specific precipitation event types or intensity can affect radial growth widths despite no changes in overall precipitation amount. Here, we use a longleaf pine latewood chronology to demonstrate how infrequent, intense (i.e., > 2.0 SD above mean) rainfall events (IREs), representing ~ 50% of total summer (July–September) precipitation amounts and 14.1% of rainfall events, principally determine interannual variability …

Regulatory Malfunctions In The Drug Patent Ecosystem, Ana Santos Rutschman

Faculty Publications

Patent protection for several of the world’s best-selling and most promising drugs—biologics—has begun waning. Over the next few years, many other drugs in this category will lose critical patent protection. In principle, this should open the United States market to competition, as more manufacturers are now able to produce relatively cheaper versions of these expensive drugs, known as biosimilars. That, however, has not been the case. This Article examines this problem in the context of the articulation between anticompetitive behaviors and regulatory interventions in the biopharmaceutical arena and argues for a novel solution: a timelier response provided by the U.S. …

Detection Of Hydroxyl Radicals Using Cerium Oxide/Graphene Oxide Composite On Prussian Blue, Surachet Duanghathaipornsuk, Sushil R. Kanel, Emily F. Haushalter, Jessica Ruetz, Dong-Shik Kim

Faculty Publications

A composite sensor consisting of two separate inorganic layers of Prussian blue (PB) and a composite of cerium oxide nanoparticles (CeNPs) and graphene oxide (GO), is tested with •OH radicals. The signals from the interaction between the composite layers and •OH radicals are characterized using cyclic voltammetry (CV). The degradation of PB in the presence of H₂O₂ and •OH radicals is observed and its impact on the sensor efficiency is investigated. The results show that the composite sensor differentiates between the solutions with and without •OH radicals by the increase of electrochemical redox current in the presence …

Morphometric Response Of Galaxias Maculatus (Jenyns) To Lake Colonization In Chile, Margaret Mercer, Peter C. Searle, Roberto Cifuentes, Evelyn Habit, Mark C. Belk

Faculty Publications

Body and head shape in fish responds to environmental factors such as water flow rate, food sources, and niche availability. However, the way in which fish respond to these environmental factors varies. In Central Chile, multiple river and lake systems along the coast provide an ideal study site to investigate these types of shape changes. We use geometric morphometrics to characterize shape differences in Galaxias maculatus (Jenyns) between river and lake populations. Lake fish converge on a shape with a more fusiform body, narrower head, and larger eyes, while river fish have a more robust body, rounder head, and smaller …

The Abundant-Centre Is Not All That Abundant: A Comment To Osorio-Olvera Et Al. 2020, Tad Dallas, Samuel Pironon, Luca Santini

Faculty Publications

Species abundance is expected to decrease from the centre towards the edge of their ecological niches (abundant niche-centre hypothesis). Recently, Osorio-Olvera et al. (2020) reported strong support for the abundant niche-centre relationship in North American birds. We demonstrate here that methodological decisions strongly affected perceived support. Avoiding these issues casts doubt on conclusions by Osorio-Olvera et al. and the putative support for the abundant nichecentre hypothesis in North American birds.

Introducing The Journal Of Nuclear Engineering: An Interdisciplinary Open Access Journal Dedicated To Publishing Research In Nuclear And Radiation Sciences And Applications, Dan Gabriel Cacuci

Faculty Publications

Note: In lieu of an abstract, this is an excerpt from the first page.

In 1938, Strassmann, Hahn and Meitner discovered neutron-induced nuclear fission in uranium, forever changing our world and opening multiple paths to developing nuclear energy, nuclear medicine, instrumentation, space propulsion, environmental monitoring, remediation and nuclear security [...]