Digital Commons Network^™

Restriction Of Access To Deep Brain Stimulation For Refractory Ocd: Failure To Apply The Federal Parity Act, Rachel Davis, James Giordano, D Brian Hufford, Sameer A. Sheth, Peter Warnke, Alik S. Widge, R Mark Richardson, Joshua M. Rosenow, Peter Justin Rossi, Eric A. Storch, Helena Winston, Joanne Zboyan, Darin D. Dougherty, Kelly D. Foote, Wayne K. Goodman, Nicole C. Mclaughlin, Steven Ojemann, Steven Rasmussen, Aviva Abosch, Michael S. Okun

Faculty Publications

No abstract provided.

Bridging The Informal And Formal Learning Spaces With Whatsapp, Tutaleni I. Asino, Nandita Gurjar, Perien Boer

Faculty Publications

When it comes to digital-based learning, the question of engagement and presence is often focused on online learning involving traditional computing devices such as desktop computers or laptops. However, in areas where mobile devices are the most widely used computing technology, engagement and interaction between teachers and students looks different. In many parts of the world, interactions between individuals takes place through mobile texting applications to bridge formal and informal learning spaces.

One of the most popular mobile tools is WhatsApp, a free cross-platform mobile application that allows users to make calls (voice) and send messages (text). The app averages …

Toward Uncharted Territory Of Cellular Heterogeneity: Advances And Applications Of Single-Cell Rna-Seq, Brandon Lieberman, Meena Kusi, Chia Nung Hung, Chih Wei Chou, Ning He, Yen Yi Ho, Josephine A. Taverna, Tim H.M. Huang, Chun Liang Chen

Faculty Publications

Among single-cell analysis technologies, single-cell RNA-seq (scRNA-seq) has been one of the front runners in technical inventions. Since its induction, scRNA-seq has been well received and undergone many fast-paced technical improvements in cDNA synthesis and amplification, processing and alignment of next generation sequencing reads, differentially expressed gene calling, cell clustering, subpopulation identification, and developmental trajectory prediction. scRNA-seq has been exponentially applied to study global transcriptional profiles in all cell types in humans and animal models, healthy or with diseases, including cancer. Accumulative novel subtypes and rare subpopulations have been discovered as potential underlying mechanisms of stochasticity, differentiation, proliferation, tumorigenesis, and …

Nutritional Approach For Increasing Public Health During Pandemic Of Covid-19: A Comprehensive Review Of Antiviral Nutrients And Nutraceuticals, Vahideh Ebrahimzadeh-Attari, Ghodratollah Panahi, James R. Hébert Scd, Alireza Ostadrahimi, Maryam Saghafi-Asl, Neda Lotfi-Yaghin, Behzad Baradaran

Faculty Publications

Background: The novel coronavirus (COVID-19) is considered as the most life-threatening pandemic disease during the last decade. The individual nutritional status, though usually ignored in the management of COVID-19, plays a critical role in the immune function and pathogenesis of infection. Accordingly, the present review article aimed to report the effects of nutrients and nutraceuticals on respiratory viral infections including COVID-19, with a focus on their mechanisms of action.

Methods: Studies were identified via systematic searches of the databases including PubMed/ MEDLINE, ScienceDirect, Scopus, and Google Scholar from 2000 until April 2020, using keywords. All relevant clinical and experimental studies …

Rethinking Sustainability Monitoring In The Arctic By Linking Resilience And Sustainable Development In Socially-Oriented Observations: A Perspective, Tatiana Vlasova, Andrey N. Petrov, Sergey Volkov

Faculty Publications

Monitoring of social-ecological systems dynamics and sustainability is of high importance in a rapidly changing Arctic. The goal of this essay is to discuss and articulate the principles for designing a suitable Arctic sustainability monitoring framework based on the convergence between resilience thinking and sustainable development paradigms. We propose to integrate sustainability monitoring into the socially-oriented observations (SOO) methodologies in order to design Arctic sus-tainability monitoring as a transdisciplinary participatory activity that results in both co-production of sustainability knowledge and building more sustainable and resilient Arctic social-ecological systems by enabling continuous observation and informed decision-making. Special attention is given to …

Simulating Municipal Cybersecurity Incidents: Recommendations From Expert Interviews, Kira Gedris, Kayla Bowman, Aatish Neupane, Amanda Lee Hughes, Elizabeth Bonsignore, Ryan W. West, Jon Balzotti, Derek L. Hansen

Faculty Publications

As cyberattacks on city and public infrastructures become increasingly common and harmful, it is critical that we train the professional workforce to prepare and respond appropriately. This paper supports the development of educational simulations and related experiential learning exercises that help prepare city and public infrastructure personnel to effectively respond to cybersecurity attacks. Specifically, it synthesizes the findings from 8 expert interviews including 12 cybersecurity experts from federal, state, city organizations, as well as academics with relevant expertise. We organize the findings into key learning outcomes, scenarios, roles, and issues that simulation designers should consider. The result paints a vivid …

Environmental Indifference, Anthony L. Moffa

Faculty Publications

An incarcerated American underclass, disproportionately comprised of minority citizens, has been compelled to live in an unconstitutionally polluted environment. Exposure to radon gas in indoor air is just one example of that pollution. Fortunately, the legal effort to address that particular condition of confinement has already begun; the theoretical and practical discussion in this work strives to both highlight the importance of the issue and inform the doctrinal development. The Eighth Amendment precedent created on the specific issue of radon exposure will very likely control the courts’ treatment of other environmental harms ignored by prison officials. This work, using radon …

Perspective On Nanofiber Electrochemical Sensors: Design Of Relative Selectivity Experiments, Stanley G. Feeney, Joelle M.J. Lafreniere, Jeffrey Mark Halpern

Faculty Publications

The use of nanofibers creates the ability for non-enzymatic sensing in various applications and greatly improves the sensitivity, speed, and accuracy of electrochemical sensors for a wide variety of analytes. The high surface area to volume ratio of the fibers as well as their high porosity, even when compared to other common nanostructures, allows for enhanced electrocatalytic, adsorptive, and analyte-specific recognition mechanisms. Nanofibers have the potential to rival and replace materials used in electrochemical sensing. As more types of nanofibers are developed and tested for new applications, more consistent and refined selectivity experiments are needed. We applied this idea in …

Association Between Toxoplasma Gondii Seropositivity And Serointensity And Brain Volume In Adults: A Cross-Sectional Study, Bruce L. Brown, Lance D. Erickson, Shawn D. Gale, Dawson W. Hedges

Faculty Publications

The intracellular protozoal parasite Toxoplasma gondii has been associated with worsened cognitive function in animal models and in humans. Despite these associations, the mechanisms by which Toxoplasma gondii might affect cognitive function remain unknown, although Toxoplasma gondii does produce physiologically active intraneuronal cysts and appears to affect dopamine synthesis. Using data from the UK Biobank, we sought to determine whether Toxoplasma gondii is associated with decreased prefrontal, hippocampal, and thalamic gray-matter volumes and with decreased total gray-matter and total white-matter volumes in an adult community-based sample. The results from adjusted multivariable regression modelling showed no associations between Toxoplasma gondii and …

Internal Audit Stigma Impairs Internal Audit Outcomes, Marc Eulerich, Joleen Kremin, K. Kelli Saunders, David A. Wood

Faculty Publications

Prior research finds that the internal audit function (IAF) plays a critical role in organizations, yet there is still a stigma toward the profession. We examine how this stigma affects internal audit outcomes, using three different data sources: survey results from parts of Europe and the United States and an experiment. We find that when practicing internal auditors in parts of Europe and the U.S. believe there is a negative stigma about internal auditing, they report negative work outcomes, including less ability to add value, less influence in the organization, more resistance to implementing their recommendations, and more pressure to …

Photoreceptor Phosphodiesterase (Pde6): Activation And Inactivation Mechanisms During Visual Transduction In Rods And Cones, Rick H. Cote

Faculty Publications

Rod and cone photoreceptors of the vertebrate retina utilize cGMP as the primary

intracellular messenger for the visual signaling pathway that converts a light stimulus into an electrical response. cGMP metabolism in the signal-transducing photoreceptor outer segment reflects the balance of cGMP synthesis (catalyzed by guanylyl cyclase) and degradation (catalyzed by the photoreceptor phosphodiesterase, PDE6). Upon light stimulation, rapid activation of PDE6 by the heterotrimeric G-protein (transducin) triggers a dramatic drop in cGMP levels that lead to cell hyperpolarization. Following cessation of the light stimulus, the lifetime of activated PDE6 is also precisely regulated by additional processes. This review summarizes …

Trademarks In Conversation: Assessing Genericism After Booking.Com, Laura A. Heymann

Faculty Publications

It is a fundamental principle of U.S. trademark law that to serve as a trademark, a word or phrase must “indicate the source” of the goods or services with which it is associated and, conversely, that a term that is understood to be the common name of a good or service is “generic” and cannot be protected as a trademark. Yet it still seems difficult to determine exactly what each concept means, particularly when the actual “source” of any goods or services might be opaque to consumers.

In part, this difficulty comes from the fact that status as a trademark …

The Effects Of Metacognitive Listening Strategy Instruction On Esl Learners’ Listening Motivation, Grant Eckstein, Corbin Kalanikiakahi Rivera, Benjamin L. Mcmurry, David Eddington

Faculty Publications

Prior studies examining the effects of listening strategy instruction on motivation have shown a positive correlation between the two. However, the participants of these studies all shared a first language (L1) and were not enrolled in an intensive English program (IEP). This study aims to investigate the correlation between listening strategy instruction and listening motivation in an IEP classroom for students from different L1s. Listening motivation was recorded utilizing the English Listening Comprehension Motivation Scale (ELCMS), and strategy use was tracked with the Metacognitive Awareness Listening Questionnaire (MALQ). Pre- and post-test scores of 56 participants (control group, n=30; experiment group, …

Is Germline Gene Editing Exceptional?, Myrisha S. Lewis

Faculty Publications

Advances in gene editing have recently received significant scientific and media attention. Gene editing, especially CRISPR-Cas9, has revived multiple longstanding ethical debates, including debates related to parental autonomy, health disparities, disability perspectives, and racial and economic inequalities. Germline, or heritable, gene editing generates several newer, neglected bioethical debates, including those about the shared human germline and whether there is a "line" that humans should not cross.

This Article addresses several interrelated ethical and legal questions related to germline gene editing. Those questions address why, if at all, germline gene editing needs to be regulated and, if germline gene editing needs …

Work–Leisure Blending: An Integrative Conceptual Review And Framework To Guide Future Research, Troy A. Smith, Marcus M. Butts, Stephen H. Courtright, Mat D. Duerden, Mark A. Widmer

Faculty Publications

Since the industrial revolution, work and leisure have largely been considered opposing domains. A growing number of organizations, however, enable and/or promote blending leisure activities into the workplace. Similarly, several conceptualizations across different disciplines examine how work and leisure can coexist. These different conceptualizations have yielded a rich but fragmented theoretical account of work–leisure blending. To address this problem, we provide a comprehensive theoretical integration of multiple literature streams where research has explored work–leisure blending. Further, we develop a tripartite dimensional framework designed to elucidate the central dimensions of work–leisure blending (i.e., segmentation– integration, unstructured–structured, and independent–interactive) undergirding this phenomenon. …

State Anxiety Moderates The Association Between Motivations And Excessive Smartphone Use, Xi Shen, Hai-Zhen Wang, Detlef H. Rost, James Gaskin, Jin-Liang Wang

Faculty Publications

Excessive smartphone use has recently attracted researchers’ attention. Previous studies have suggested that state anxiety and motivations are important predictors of excessive smartphone use. However, few studies have investigated how motivations and state anxiety interact with each other, and the subsequent impact on excessive smartphone use. In the current study, based on the Compensatory Internet Use theory, we analyzed the moderating role of state anxiety on the relationship between two types of motivations (i.e. entertainment and social interaction) and excessive smartphone use. Using the Smartphone Addiction Scale for College Students (SAS-C), Smartphone Usage Motivation Scale and State Anxiety Scale (S-Anxiety), …

Effects Of Body Temperature On Initial Bite Force In Three Species Of Rock- And Crevice-Dwelling Lizards From Mexico, Guillermo A. Woolrich-Piña, Geoffrey R. Smith, Norberto Martínez-Méndez, Julio A. Lemos-Espinal, Héctor Gadsden-Esparz

Faculty Publications

No abstract provided.

Fecal Pellet Mass As A Function Of Body Size, Color Morph, And Season In Plethodon Cinereus (Green, 1818) (Amphibia: Plethodontidae), Geoffrey R. Smith, Abhishek V. Henry, Logan E. Smith, Wesley O. Smith

Faculty Publications

No abstract provided.

Data Science In Undergraduate Life Science Education: A Need For Instructor Skills Training, Nathan C. Emery, Erika Crispo, Sarah R. Supp, Kaitlin J. Farrell, Andrew J. Kerkhoff

Faculty Publications

No abstract provided.

A Statistical Analysis Of Drug Seizures And Opioid Overdose Deaths In Ohio From 2014 To 2018, David White, Lam Tran, Lin Ma

Faculty Publications

No abstract provided.

Bright Chromenylium Polymethine Dyes Enable Fast, Four-Color "In Vivo" Imaging With Shortwave Infrared Detection, Emily D. Cosco, Bernardo A. Arús, Anthony L. Spearman, Timothy Luke Atallah, Irene Lim

Faculty Publications

No abstract provided.

Data Science In Undergraduate Life Science Education: A Need For Instructor Skills Training, Nathan C. Emery, Erika Crispo, Sarah R. Supp, Kaitlin J. Farrell, Andrew J. Kerkhoff

Faculty Publications

No abstract provided.

Estimating The Movements Of Terrestrial Animal Populations Using Broad-Scale Occurrence Data, Sarah R. Supp, Gil Bohrer, John Fieberg, Frank A. La Sorte

Faculty Publications

No abstract provided.

Long‐Term Changes In Temperate Marine Fish Assemblages Are Driven By A Small Subset Of Species, Nicholas J. Gotelli, Faye Moyes, Laura H. Antão, Shane A. Blowes, Sarah R. Supp

Faculty Publications

No abstract provided.

Vegf-A, Pdgf-Bb And Hb-Egf Engineered For Promiscuous Super Affinity To The Extracellular Matrix Improve Wound Healing In A Model Of Type 1 Diabetes, Michael J. White, Priscilla S. Briquez, David White, Jeffrey A. Hubbell

Faculty Publications

No abstract provided.

When Therapy Goes Public: Copyright Gatekeepers And Sharing Therapeutic Artifacts On Social Media, Amanda Reid, Pablo Miño

Faculty Publications

No abstract provided.

Migrating Genes: Using Adna And Archaeological Data To Explain Migration In The Casas Grandes Region Of Northern Mexico, Meradeth Snow, Michael T. Searcy

Faculty Publications

Migration as an archaeological topic has addressed huge distances, such as the colonization of the Americas, as well as smaller regions, such as the peopling of specific sites. The use of genetics as a medium to enhance our understanding of population movement can be an asset. There are potential pitfalls, however, such as the misrepresentation of DNA ranging across the landscape without human vectors or motivations. Genetic data must be interpreted through the lens of all available data from the site and surrounding region in order to understand how it its into the potential for human migration. These ideas will …

Photoreceptor Phosphodiesterase (Pde6): Structure, Regulatory Mechanisms, And Implications For Treatment Of Retinal Diseases, Rick H. Cote, Richa Gupta, Michael J. Irwin, Xin Wang

Faculty Publications

The photoreceptor phosphodiesterase (PDE6) is a member of large family of Class I phosphodiesterases responsible for hydrolyzing the second messengers cAMP and cGMP. PDE6 consists of two catalytic subunits and two inhibitory subunits that form a tetrameric protein. PDE6 is a peripheral membrane protein that is localized to the signaling-transducing compartment of rod and cone photoreceptors. As the central effector enzyme of the G-protein coupled visual transduction pathway, activation of PDE6 catalysis causes in a rapid decrease in cGMP levels that results in closure of cGMP-gated ion channels in the photoreceptor plasma membrane. Because of its importance in the phototransduction …

Swimming Against The Flow: Environmental Dna Can Detect Bull Sharks (Carcharhinus Leucas) Across A Dynamic Deltaic Interface, James Marcus Drymon, Katherine E. Schweiss, Emily A. Seubert, Ryan N. Lehman, Toby S. Daly-Engel, Mariah Pfleger, Nicole M. Phillips

Faculty Publications

© 2020 The Authors. Ecology and Evolution published by John Wiley & Sons Ltd Human activities in coastal areas are accelerating ecosystem changes at an unprecedented pace, resulting in habitat loss, hydrological modifications, and predatory species declines. Understanding how these changes potentially cascade across marine and freshwater ecosystems requires knowing how mobile euryhaline species link these seemingly disparate systems. As upper trophic level predators, bull sharks (Carcharhinus leucas) play a crucial role in marine and freshwater ecosystem health. Telemetry studies in Mobile Bay, Alabama, suggest that bull sharks extensively use the northern portions of the bay, an estuarine–freshwater interface known …

A Story Of Bodying In Science Education, Christie C. Byers, Maria F.G. Wallace

Faculty Publications

In poetic dialogue with BecomingAlivewithinScienceEducation(Research):ThinkingwithLifeHistory(ies),BodiesandStickiness, stories of bodying and body(ies) of work are playfully explored.