Digital Commons Network^™

Spoken Word Learning In Children With Developmental Language Disorder Or Dyslexia, Suzanne M. Adlof, Lauren S. Baron, Bethany A. Bell, Joanna Scoggins

Faculty Publications

Purpose Word learning difficulties have been documented in multiple studies involving children with dyslexia and developmental language disorder (DLD; see also specific language impairment). However, no previous studies have directly contrasted word learning in these two frequently co-occurring disorders. We examined word learning in second-grade students with DLD-only and dyslexia-only as compared to each other, peers with both disorders (DLD + dyslexia), and peers with typical development. We hypothesized that children with dyslexia-only and DLD-only would show differences in word learning due to differences in their core language strengths and weaknesses. Method Children ( = 244) were taught eight novel …

Andrographolide Attenuates Gut-Brain-Axis Associated Pathology In Gulf War Illness By Modulating Bacteriome-Virome Associated Inflammation And Microglia-Neuron Proinflammatory Crosstalk, Punnag Saha, Peter T. Skidmore, Larinda A. Holland, Ayan Mondal, Dipro Bose, Ratanesh K. Seth, Kimberly Sullivan, Patricia A. Janulewicz, Ronnie Horner, Nancy Klimas, Mitzi Nagarkatti, Prakash Nagarkatti, Efrem S. Lim, Saurabh Chatterjee

Faculty Publications

Gulf War Illness (GWI) is a chronic multi-symptomatic illness that is associated with fatigue, pain, cognitive deficits, and gastrointestinal disturbances and presents a significant challenge to treat in clinics. Our previous studies show a role of an altered Gut-Brain axis pathology in disease development and symptom persistence in GWI. The present study utilizes a mouse model of GWI to study the role of a labdane diterpenoid andrographolide (AG) to attenuate the Gut-Brain axis-linked pathology. Results showed that AG treatment in mice (100 mg/kg) via oral gavage restored bacteriome alterations, significantly increased probiotic bacteria , , and , the genera that …

Effects Of Beach Nourishment Project On Coastal Geomorphology And Mangrove Dynamics In Southern Louisiana, Usa, Marcelo Cancela Lisboa Cohen, Adriana Vivan De Souza, Kam-Biu Liu, Erika Rodrigues, Qiang Yao, Luiz Carlos Ruiz Pessenda, Dilce Rossetti, Junghyung Ryu, Marianne Dietz

Faculty Publications

No abstract provided.

An Operational Overview Of The Export Processes In The Ocean From Remote Sensing (Exports) Northeast Pacific Field Deployment, David A. Siegel, Ivona Cetinic, Jason R. Graff, Craig M. Lee, Norman Nelson, Mary Jane Perry, Inia Soto Ramos, Deborah K. Steinberg, Ken Buesseler, Roberta Hamme, Andrea J. Fassbender, David Nicholson, Melissa M. Omand, Marie Robert, Andrew Thompson, Vinicius Amaral, Michael Behrenfeld, Claudia R. Benitez-Nelson, Kelsey Bisson, Emmanuel Boss, Et. Al.

Faculty Publications

The goal of the EXport Processes in the Ocean from RemoTe Sensing (EXPORTS) field campaign is to develop a predictive understanding of the export, fate, and carbon cycle impacts of global ocean net primary production. To accomplish this goal, observations of export flux pathways, plankton community composition, food web processes, and optical, physical, and biogeochemical (BGC) properties are needed over a range of ecosystem states. Here we introduce the first EXPORTS field deployment to Ocean Station Papa in the Northeast Pacific Ocean during summer of 2018, providing context for other papers in this special collection. The experiment was conducted with …

Identification Of Human Kinin-Forming Enzyme Inhibitors From Medicinal Herbs, Hassan Madkhali, Amer Tarawneh, Zulfiqar Ali, Hoang V. Le, Stephen J. Cutler Ph.D.

Faculty Publications

The goal of this study was to assess the pharmacological effects of black tea (Camellia sinensis var. assamica) water extract on human kinin-forming enzymes in vitro. Tea is a highly consumed beverage in the world. Factor XII (FXII, Hageman factor)-independent- and -dependent activation of prekallikrein to kallikrein leads to the liberation of bradykinin (BK) from high-molecular-weight kininogen (HK). The excessive BK production causes vascular endothelial and nonvascular smooth muscle cell permeability, leading to angioedema. The prevalence of angiotensin-converting enzyme inhibitor (ACEI)-induced angioedema appears to be through BK. Both histamine and BK are potent inflammatory mediators. However, the treatments for histamine-mediated …

Cognitive Complaints In Age-Related Chronic Conditions: A Systematic Review, Nikki L. Hill, Sakshi Bhargava, Monique J. Brown, Hyejin Kim, Iris Bhang, Kaitlyn Mullin, Kathleen Phillips, Jacqueline Mogle

Faculty Publications

Introduction

Cognitive complaints in older adults may be indicative of progressive cognitive decline including Alzheimer’s disease (AD), but also occur in other age-related chronic conditions, complicating identification of early AD symptoms. To better understand cognitive complaints in aging, we systematically reviewed the evidence to determine their prevalence and characterization among older adults with the most common age-related chronic conditions.

Methods

This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement and the review protocol was prospectively registered with PROSPERO (ID: CRD42020153147). Searches were conducted in PubMed, CINAHL, PsycINFO, Web of Science, and …

An Operational Overview Of The Export Processes In The Ocean From Remote Sensing (Exports) Northeast Pacific Field Deployment, David A. Siegel, Ivona Cetinić, Jason R. Graff, Craig M. Lee, Norman Nelson, Mary Jane Perry, Inia Soto Ramos, Deborah K. Steinberg, Ken Buesseler, Roberta Hamme, Andrea J. Fassbender, David Nicholson, Melissa M. Omand, Marie Robert, Andrew Thompson, Vinicius Amaral, Michael Behrenfeld, Claudia Benitez-Nelson, Kelsey Bisson, Emmanuel Boss, Philip W. Boyd, Mark Brzezinski, Kristen Buck

Faculty Publications

The goal of the EXport Processes in the Ocean from RemoTe Sensing (EXPORTS) field campaign is to develop a predictive understanding of the export, fate, and carbon cycle impacts of global ocean net primary production. To accomplish this goal, observations of export flux pathways, plankton community composition, food web processes, and optical, physical, and biogeochemical (BGC) properties are needed over a range of ecosystem states. Here we introduce the first EXPORTS field deployment to Ocean Station Papa in the Northeast Pacific Ocean during summer of 2018, providing context for other papers in this special collection. The experiment was conducted with …

Molecular Markers Of Biogenic And Oil-Derived Hydrocarbons In Deep-Sea Sediments Following The Deepwater Horizon Spill, Isabel C. Romero, Jeffrey P. Chanton, Gregg Brooks, Samantha Bosman, Rebekka A. Larson, Austin Harris, Patrick Schwing, Arne Diercks

Faculty Publications

Following the Deepwater Horizon oil spill (DWHOS), the formation of an unexpected and extended sedimentation event of oil-associated marine snow (MOSSFA: Marine Oil Snow Sedimentation and Flocculent Accumulation) demonstrated the importance of biology on the fate of contaminants in the oceans. We used a wide range of compound-specific data (aliphatics, hopanes, steranes, triaromatic steroids, polycyclic aromatics) to chemically characterize the MOSSFA event containing abundant and multiple hydrocarbon sources (e.g., oil residues and phytoplankton). Sediment samples were collected in 2010–2011 (ERMA-NRDA programs: Environmental Response Management Application – Natural Resource Damage Assessment) and 2018 (REDIRECT project: Resuspension, Redistribution and Deposition of Deepwater …

Nanoparticles For Targeted Drug Delivery To Cancer Stem Cells: A Review Of Recent Advances, Yavuz Nuri Ertas, Keyvan Abedi Dorcheh, Ali Akbari, Esmaiel Jabbari

Faculty Publications

Cancer stem cells (CSCs) are a subpopulation of cells that can initiate, self-renew, and sustain tumor growth. CSCs are responsible for tumor metastasis, recurrence, and drug resistance in cancer therapy. CSCs reside within a niche maintained by multiple unique factors in the microenvironment. These factors include hypoxia, excessive levels of angiogenesis, a change of mitochondrial activity from aerobic aspiration to aerobic glycolysis, an upregulated expression of CSC biomarkers and stem cell signaling, and an elevated synthesis of the cytochromes P450 family of enzymes responsible for drug clearance. Antibodies and ligands targeting the unique factors that maintain the niche are utilized …

Nanoparticles For Targeted Drug Delivery To Cancer Stem Cells: A Review Of Recent Advances, Yavuz Nuri Ertas, Keyvan Abedu Dorcheh, Ali Akbari, Esmaiel Jabbari

Faculty Publications

Cancer stem cells (CSCs) are a subpopulation of cells that can initiate, self-renew, and sustain tumor growth. CSCs are responsible for tumor metastasis, recurrence, and drug resistance in cancer therapy. CSCs reside within a niche maintained by multiple unique factors in the microenvironment. These factors include hypoxia, excessive levels of angiogenesis, a change of mitochondrial activity from aerobic aspiration to aerobic glycolysis, an upregulated expression of CSC biomarkers and stem cell signaling, and an elevated synthesis of the cytochromes P450 family of enzymes responsible for drug clearance. Antibodies and ligands targeting the unique factors that maintain the niche are utilized …

Analyzing Satellite Ocean Color Match-Up Protocols Using The Satellite Validation Navy Tool (Savant) At Moby And Two Aeronet-Oc Sites, Adam Lawson, Jennifer Bowers, Sherwin Ladner, Richard Crout, Christopher Wood, Robert Arnone, Paul Martinolich, David Lewis

Faculty Publications

The satellite validation navy tool (SAVANT) was developed by the Naval Research Laboratory to help facilitate the assessment of the stability and accuracy of ocean color satellites, using numerous ground truth (in situ) platforms around the globe and support methods for match-up protocols. The effects of varying spatial constraints with permissive and strict protocols on match-up uncertainty are evaluated, in an attempt to establish an optimal satellite ocean color calibration and validation (cal/val) match-up protocol. This allows users to evaluate the accuracy of ocean color sensors compared to specific ground truth sites that provide continuous data. Various match-up constraints may …

Do Neighbours Matter? The Effect Of Single‐ And Mixed‐Species Sowing Density On Seed Germination Of Annual Wetland Plants, Francielli Bao, Davi Rodrigo Rossatto, Arnildo Pott, Tracy Elsey‐Quirk, Marco Antonio Assis, Rafael Arruda, Desirée Marques Ramos, Borja Jiménez‐Alfaro

Faculty Publications

No abstract provided.

Phylogenomic Analyses Reveal Non-Monophyly Of The Antbird Genera Herpsilochmus And Sakesphorus (Thamnophilidae), With Description Of A New Genus For Herpsilochmus Sellowi, G A. Bravo, B M. Whitney, R Belmonte-Lopes, M R. Bornschein, G A. Bravo, R Beco, J Battilana, L N. Naka, A Aleixo, M R. Pie, L F. Silveira, E P. Derryberry, R T. Brumfield

Faculty Publications

The family Thamnophilidae is a species-rich Neotropical radiation of passerine birds. Current classification of its 235 species is mostly based on morphological similarities, but recent studies integrating comprehensive phenotypic and phylogenetic data have redefined taxonomic limits of several taxa. Here, we assess generic relationships of Herpsilochmus, Sakesphorus, Thamnophilus, Biatas, and Dysithamnus using DNA sequences from the mitochondrion, nuclear exons, and ultraconserved elements, with further attention to interspecific relationships within Herpsilochmus. We show that Herpsilochmus and Sakesphorus are not monophyletic. We resolve Herpsilochmus sellowi as a deep-branch sister to the monotypic genus Biatas and Sakesphorus cristatus as sister to a clade …

Changes In The Microbial Community In Soybean Plots Treated With Biochar And Poultry Litter, Rosalie B. Calderon, Changyoon Jeong, Hyun Hwoi Ku, Lyndon M. Coghill, Young Jeong Ju, Nayong Kim, Jong Hyun Ham

Faculty Publications

The application of organic materials that promote beneficial microbial activity is vital to maintaining soil health and crop productivity. We investigated the effect on the soil microbiome of applying biochar (BC), poultry litter (PL), and a combination of biochar and poultry litter (BC/PL) in soybean cultivation at the Red River Research Station (Bossier City, LA, USA). We characterized the microbial profiles, community structure, and co-occurrence network from sequencing data to infer microbial interactions in the soil samples collected in the first and second years of each soil treatment (2016 and 2017, respectively). Our results showed that soil treatments with BC, …

Breeding Ecology Of Mottled Ducks: A Review, Elizabeth S. Bonczek, Kevin M. Ringelman

Faculty Publications

Mottled ducks (Anas fulvigula) are endemic to the Gulf Coast of North America, and their range stretches from Alabama to the Laguna Madre of Mexico, with a distinct population in peninsular Florida and an introduced population in South Carolina. As one of the few non-migratory ducks in North America, mottled ducks depend on a variety of locally available habitat throughout the annual cycle, and threats to these landscapes may affect mottled ducks more acutely than migratory species. Annual population monitoring has revealed declines in mottled duck populations in Texas and Louisiana since 2008, and the genetic integrity of the Florida …

Stable Isotope Analyses Identify Trophic Niche Partitioning Between Sympatric Terrestrial Vertebrates In Coastal Saltmarshes With Differing Oiling Histories, Sydney Moyo, Hayat Bennadji, Danielle Laguaite, Anna A. Pérez-Umphrey, Allison M. Snider, Andrea Bonisoli-Alquati, Jill A. Olin, Philip C. Stouffer, Sabrina S. Taylor, Paola C. López-Duarte, Brian J. Roberts, Linda Hooper-Bui, Michael J. Polito

Faculty Publications

Bioindicator species are commonly used as proxies to help identify the ecological effects of oil spills and other stressors. However, the utility of taxa as bioindicators is dependent on understanding their trophic niche and life history characteristics, as these factors mediate their ecological responses. Seaside sparrows (Ammospiza maritima) and marsh rice rats (Oryzomys palustris) are two ubiquitous terrestrial vertebrates that are thought to be bioindicators of oil spills in saltmarsh ecosystems. To improve the utility of these omnivorous taxa as bioindicators, we used carbon and nitrogen stable isotope analysis to quantify their trophic niches at saltmarshes in coastal Louisiana with …

Hydraulic Architecture Explains Species Moisture Dependency But Not Mortality Rates Across A Tropical Rainfall Gradient, Alexandria L. Pivovaroff, Brett T. Wolfe, Nate Mcdowell, Bradley Christoffersen, Stuart Davies, L. Turin Dickman, Charlotte Grossiord, Riley T. Leff, Alistair Rogers, Shawn P. Serbin, S. Joseph Wright, Jin Wu, Chonggang Xu, Jeffrey Q. Chambers

Faculty Publications

Intensified droughts are affecting tropical forests across the globe. However, the underlying mechanisms of tree drought response and mortality are poorly understood. Hydraulic traits and especially hydraulic safety margins (HSMs), that is, the extent to which plants buffer themselves from thresholds of water stress, provide insights into species-specific drought vulnerability. We investigated hydraulic traits during an intense drought triggered by the 2015–2016 El Niño on 27 canopy tree species across three tropical forest sites with differing precipitation. We capitalized on the drought event as a time when plant water status might approach or exceed thresholds of water stress. We investigated …

Microbial Abundance And Enzymatic Activity From Tussock And Shrub Soil In Permafrost Peatland After 6-Year Warming, Yanyu Song, Lei Jiang, Changchun Song, Xianwei Wang, Xiuyan Ma, Hao Zhang, Wenwen Tan, Jinli Gao, Aixin Hou

Faculty Publications

Soil microbes and enzymes in permafrost peatland are sensitive to temperature changes, which might result in more potential loss of carbon and increase in available nitrogen from permafrost peatlands in a warming world. We previously demonstrated that 3-year warming could affect soil microbial abundance and enzymatic activity. However, soil microbial abundance and enzymatic activity in permafrost peatlands under long-term climate warming is not well understood. Therefore, a 6-year field manipulation experiment was used to assess the impact of long-term warming on soil microbial abundance and enzymatic activity in a permafrost peatland in northeastern China. Results showed that 6-year warming increased …

Molecular Evolution Of Ecological Specialisation: Genomic Insights From The Diversification Of Murine Rodents, Emily Roycroft, Anang Achmadi, Colin M. Callahan, Jacob A. Esselstyn, Jeffrey M. Good, Adnan Moussalli, Kevin C. Rowe

Faculty Publications

Adaptive radiations are characterized by the diversification and ecological differentiation of species, and replicated cases of this process provide natural experiments for understanding the repeatability and pace ofmolecular evolution.During adaptive radiation, genes related to ecological specialization may be subject to recurrent positive directional selection. However, it is not clear to what extent patterns of lineage-specific ecological specialization (includingphenotypic convergence) are correlatedwithsharedsignatures of molecular evolution. To test this, we sequenced whole exomes from a phylogenetically dispersed sample of 38 murine rodent species, a group characterized bymultiple, nested adaptive radiations comprising extensive ecological and phenotypic diversity.We found that genes associatedwithimmunity, reproduction, diet, …

Optimizing Genomic-Enabled Prediction In Small-Scale Maize Hybrid Breeding Programs: A Roadmap Review, Roberto Fritsche-Neto, Giovanni Galli, Karina Lima Reis Borges, Germano Costa-Neto, Filipe Couto Alves, Felipe Sabadin, Danilo Hottis Lyra, Pedro Patric Pinho Morais, Luciano Rogério Braatz De Andrade, Italo Granato, Jose Crossa

Faculty Publications

The usefulness of genomic prediction (GP) for many animal and plant breeding programs has been highlighted for many studies in the last 20 years. In maize breeding programs, mostly dedicated to delivering more highly adapted and productive hybrids, this approach has been proved successful for both large- and small-scale breeding programs worldwide. Here, we present some of the strategies developed to improve the accuracy of GP in tropical maize, focusing on its use under low budget and small-scale conditions achieved for most of the hybrid breeding programs in developing countries. We highlight the most important outcomes obtained by the University …

Individual Quality And Phenology Mediate The Effect Of Radioactive Contamination On Body Temperature In Chernobyl Barn Swallows, Zbyszek Boratynski, Timothy A. Mousseau, Anders Pape Moller

Faculty Publications

Anthropogenic stressors, such as radioactive contaminants released from the Chernobyl and Fukushima Daiichi accidents, deteriorate ecological and evolutionary processes, as evidence for damaging effects of radioactive contamination on wildlife is accumulating. Yet little is known about physiological traits of animals inhabiting contaminated areas, and how those are affected by individual quality and phenology. We investigated variation in body temperature of wild barn swallows, Hirundo rustica, exposed to radioactive contamination from the Chernobyl accident in Ukraine and Belarus. We tested whether exposure to variable levels of radioactive contamination modified core body temperature of birds, and whether individual and phenological characteristics modulated …

Rabies Postexposure Prophylaxis In The United States: Opportunities To Improve Access, Coordination, And Delivery, Gavin T. Howington, Huy-Binh Nguyen, P Brandon Bookstaver, Peter Akpunonu, Joshua T. Swan

Faculty Publications

No abstract provided.

Perspective: The Importance Of Water Security For Ensuring Food Security, Good Nutrition, And Well-Being, Sera L. Young, Edward A. Frongillo Jr., Zeina Jamaluddine, Hugo Melgar-Quiñonez, Rafael Pérez-Escamilla, Claudia Ringler, Asher Y. Rosinger

Faculty Publications

Water security is a powerful concept that is still in its early days in the field of nutrition. Given the prevalence and severity of water issues and the many interconnections between water and nutrition, we argue that water security deserves attention commensurate with its importance to human nutrition and health. To this end, we first give a brief introduction to water insecurity and discuss its conceptualization in terms of availability, access, use, and stability. We then lay out the empirical grounding for its assessment. Parallels to the food-security literature are drawn throughout, both because the concepts are analogous and food …

Investigating Developmental Changes In Scalp-To-Cortex Correspondence Using Diffuse Optical Tomography Sensitivity In Infancy, Xiaoxue Fu, John E. Richards

Faculty Publications

Significance: Diffuse optical tomography (DOT) uses near-infrared light spectroscopy (NIRS) to measure changes in cerebral hemoglobin concentration. Anatomical interpretations of NIRS data require accurate descriptions of the cranio-cerebral relations and DOT sensitivity to the underlying cortical structures. Such information is limited for pediatric populations because they undergo rapid head and brain development.

Aim: We aim to investigate age-related differences in scalp-to-cortex distance and mapping between scalp locations and cortical regions of interest (ROIs) among infants (2 weeks to 24 months with narrow age bins), children (4 and 12 years), and adults (20 to 24 years).

Approach: We …

Resuspension, Redistribution, And Deposition Of Oil-Residues To Offshore Depocenters After The Deepwater Horizon Oil Spill, Arne R. Diercks, Isabel C. Romero, Rebekka A. Larson, Patrick Schwing, Austin Harris, Samantha Bosman, Jeffrey P. Chanton, Gregg Brooks

Faculty Publications

The focus of this study was to determine the long-term fate of oil-residues from the 2010 Deepwater Horizon (DwH) oil spill due to remobilization, transport, and re-distribution of oil residue contaminated sediments to down-slope depocenters following initial deposition on the seafloor. We characterized hydrocarbon residues, bulk sediment organic matter, ease of resuspension, sedimentology, and accumulation rates to define distribution patterns in a 14,300 km2 area southeast of the DwH wellhead (1,500 to 2,600 m water depth). Oil-residues from the DwH were detected at low concentrations in 62% of the studied sites at specific sediment layers, denoting episodic deposition of oil-residues …

Free Three-Dimensional Carborane Carbanions, H.D.A. Zzzchathumal Jayaweera, Md. Mamdudur Rahman, Perry J. Pellechia, Mark D. Smith, Dmitry V. Peryshkov

Faculty Publications

Carbon atom functionalization via generation of carbanions is the cornerstone of carborane chemistry. In this work, we report the synthesis and structural characterization of free ortho-carboranyl [C₂B₁₀H₁₁]⁻, a three-dimensional inorganic analog of the elusive phenyl anion that features a “naked” carbanion center. The first example of a stable, discrete C(H)-deprotonated carborane anion was isolated as a completely separated ion pair with a crown ether-encapsulated potassium cation. An analogous approach led to the isolation and structural characterization of a doubly deprotonated 1,1′-bis(o-carborane) anion [C₂B₁₀H₁₀] …

A Qualitative Study Of Stress And Coping To Inform The Leads Health Promotion Trial For African American Adolescents With Overweight And Obesity, Mary Quattlebaum, Colby Kipp, Dawn Wilson-King, Allison Sweeney Ph.D.

Faculty Publications

The purpose of this study was to conduct in-depth individual interviews with 30 African American adolescents with overweight and obesity and their families (caregiver/adolescent dyads) to gain a better understanding of how to integrate stress and coping essential elements into an existing family-based health promotion program for weight loss. Interview data from 30 African American adolescents with overweight and obesity (Mage = 15.30 ± 2.18; MBMI%-ile = 96.7 ± 3.90) were transcribed and coded for themes using inductive and deductive approaches by two independent coders. Inter-rater reliability was acceptable (r = 0.70–0.80) and discrepancies were resolved to 100% agreement. The …

Concentrations, Ratios, And Sinking Fluxes Of Major Bioelements At Ocean Station Papa, Montserrat Roca-Martí

Faculty Publications

Fluxes of major bioelements associated with sinking particles were quantified in late summer 2018 as part of the EXport Processes in the Ocean from RemoTe Sensing (EXPORTS) field campaign near Ocean Station Papa in the subarctic northeast Pacific. The thorium-234 method was used in conjunction with size-fractionated (1–5, 5–51, and >51 μm) concentrations of particulate nitrogen (PN), total particulate phosphorus (TPP), biogenic silica (bSi), and particulate inorganic carbon (PIC) collected using large volume filtration via in situ pumps. We build upon recent work quantifying POC fluxes during EXPORTS. Similar remineralization length scales were observed for both POC and PN across …

Review Of The Analysis Of 234Th In Small Volume (2–4 L) Seawater Samples: Improvements And Recommendations, Samantha J. Clevenger, Claudia Benitez-Nelson, Jessica Drysdale, Steven Pike, Viena Puigcorbé, Ken O. Buesseler

Faculty Publications

Schools may be one important context where adolescents learn and shape the behaviors necessary for promoting global inclusivity in adulthood. Given the importance of bystanders in halting bullying and peer aggression, the focus of this study is on both moral judgments regarding one type of bullying, social exclusion, and factors that are associated with bystander intervention. The study includes 896 adolescents, who were 6th (N = 450, M_age = 11.73), and 9th (N = 446, M_age = 14.82) graders, approximately evenly divided by gender. Participants were primarily European–American (63.3%). Results revealed that girls and participants who …

Clinical Correlations Of Polycomb Repressive Complex 2 In Different Tumor Types, Maksim Erokhin, Olga Chetverina, Balázs Győrffy, Victor V. Tatarskiy, Vladic Mogila, Alexander A. Shtil, Igor Roninson, Jerome Moreaux, Pavel Georgiev, Giacomo Cavalli, Darya Chetverina

Faculty Publications

PRC2 (Polycomb repressive complex 2) is an evolutionarily conserved protein complex required to maintain transcriptional repression. The core PRC2 complex includes EZH2, SUZ12, and EED proteins and methylates histone H3K27. PRC2 is known to contribute to carcinogenesis and several small molecule inhibitors targeting PRC2 have been developed. The present study aimed to identify the cancer types in which PRC2 targeting drugs could be beneficial. We queried genomic and transcriptomic (cBioPortal, KMplot) database portals of clinical tumor samples to evaluate clinical correlations of PRC2 subunit genes. EZH2, SUZ12, and EED gene amplification was most frequently found in prostate cancer, whereas lymphoid …