Digital Commons Network^™

Association Of Nucleoside Reverse Transcriptase Inhibitor Use With Reduced Risk Of Alzheimer's Disease Risk, Joseph Magagnoli Ph.D., Ms, Meenakshi Ambati, Tammy H. Cummings, Joseph Nguyen, Claire C. Thomas, Vidya L. Ambati, S. Scott Sutton, Bradley D. Gelfand, Jayakrishna Ambati

Faculty Publications

INTRODUCTION

Inflammasome activation is implicated in Alzheimer's disease (AD). We previously demonstrated that nucleoside reverse transcriptase inhibitors (NRTIs), drugs approved to treat human immunodeficiency virus (HIV) and hepatitis B, also inhibit inflammasome activation.

METHODS

We evaluated the association between NRTI exposure and subsequent development of AD in the United States Veterans Health Administration over a 24-year period and in the MarketScan database over a 14-year period using propensity score-matched multivariate Cox hazards regression and Kaplan–Meier analyses.

RESULTS

We report that in humans, NRTI exposure was associated with a significantly lower incidence of AD in two of the largest health insurance …

Immigration Policy In The Second Trump Administration: Restriction, Removal, And The Limits Of Maga Nativism, Caroline R. Nagel

Faculty Publications

Donald Trump's three presidential campaigns have centred on promises to stop unauthorised immigration, whether by ‘building the wall’ or by enacting the largest mass deportation in American history. To deliver on these promises, Trump has appointed Stephen Miller—an anti-immigration hardliner who was responsible for the first Trump administration's draconian border policies – to a key White House position. Trump is often described as breaking from liberal-democratic norms; but when it comes to immigration policy, he is following a well-worn path by hiring Miller. This brief commentary places the Trump/Miller brand of anti-immigration politics in historical context, showing how anxieties over …

Immigration Policy In The Second Trump Administration: Restriction, Removal, And The Limits Of Maga Nativism, Caroline R. Nagel

Faculty Publications

Donald Trump's three presidential campaigns have centred on promises to stop unauthorised immigration, whether by ‘building the wall’ or by enacting the largest mass deportation in American history. To deliver on these promises, Trump has appointed Stephen Miller—an anti-immigration hardliner who was responsible for the first Trump administration's draconian border policies – to a key White House position. Trump is often described as breaking from liberal-democratic norms; but when it comes to immigration policy, he is following a well-worn path by hiring Miller. This brief commentary places the Trump/Miller brand of anti-immigration politics in historical context, showing how anxieties over …

Whole-Genome Assembly And Annotation Of The Firecracker Penstemon (Penstemon Eatonii), David E. Jarvis, Mikel R. Stevens, Payton Carter, Ying Fei Lin, Kate E. Jaggi, Gabriela Jijon, Teal Kalt, Jouber Calixto, Samantha Standring, Kaitlin Torres, Kayla B. Stephensen, Hayley Mangelson, Noah H. Williams, Carolyn A. Wessinger, Peter J. Maughan, Paul B. Frandsen

Faculty Publications

The penstemons are ornamental annual flowering plants native to the Intermountain West and Rocky Mountains and commonly used for urban landscaping. Elite commercial penstemons are generally susceptible to abiotic stresses, including drought, root rot, cold, and high salinity. Firecracker penstemon (Penstemon eatonii), however, is much more tolerant to these stresses than most elite cultivars. Importantly, firecracker penstemon has been reported to hybridize with many other penstemons and therefore provides the opportunity to develop more tolerant elite cultivars through strategic crossing. To facilitate the study and utilization of firecracker penstemon, we sequenced and annotated the genome of a P. …

Investigating The Suitability Of Dichotomous Responses For The Water Insecurity Experiences (Wise) Scales Using Nationally Representative Data From 39 Countries, Indira Bose, Joshua D. Miller, Hilary J. Bethancourt, Olga P. García, Hugo R. Melgar-Quiñonez, Rosana Salles-Costa, Mauro E. Delgrossi, Scott M. Miller, Tessa L. Durham, Teresa Shamah-Levy, Pablo Gaitán-Rossi, Sera L. Young, Edward A. Frongillo Jr. Ph.D.

Faculty Publications

The Water Insecurity Experiences (WISE) Scales have been validated to comparably measure water insecurity globally. The scales consist of 12 items that can be administered in approximately 3 minutes. There is interest in developing more rapid versions of the tools for when time is limited. One alternative is to use a subset of 4 items, which has been validated, but has some drawbacks. Here we investigate another alternative: dichotomous (yes/no) response options instead of the original four levels of frequency-based (polytomous) responses. We used nationally representative data from 39 countries to simulate dichotomized responses by collapsing the four levels of …

Clarifying Parens Patriae, James G. Dwyer

Faculty Publications

Throughout the Anglo-American legal world, the state claims an authority, termed parens patriae, to exert control over the lives of nonautonomous persons in ways it does not presume to control autonomous persons. Philosophers have given little attention to when and how that authority should be exercised, yet there is disagreement or confusion about this among courts and legal scholars. This article examines how parens patriae differs from other government roles, identifies which conceptions of the parens patriae role are coherent, and then presents a normative case for adopting a conception of the role as that of fiduciary for nonautonomous …

New Hands In China: Frederick And Elizabeth Crook In Asia, Karen Glenn, John Murphy, Hallie Davidson

Faculty Publications

Drawing from the Frederick W. Crook and Elizabeth F. Crook papers in the L. Tom Perry Special Collections, this exhibit features photographs, writings, and artifacts that document rural life, agricultural development, and cross-cultural exchange in China from the 1980s through the 2010s. It also highlights the humanitarian and religious contributions of Frederick W. Crook and his wife, Elizabeth Fletcher Crook, including their work with LDS Charities and their service as mission presidents in Taiwan from 1979 to 1980.

Frederick W. Crook was an agricultural economist who worked for the United States Department of Agriculture for over 30 years, specializing in …

A Remarkable Look At Sentencing For A Remarkable Set Of Drug Defendants, Douglas A. Berman, Steven L. Chanenson

Faculty Publications

A new dataset capturing sentencing outcomes for “boat defendants,” a notable group of federal drug offenders who share many characteristics, provides a fresh perspective on many different aspects of federal case-processing and drug-sentencing outcomes. This overview provides a brief look at ground- breaking research based on this dataset, which serves as an anchor article for this issue of the Federal Sentencing Reporter, followed by a history of the creation of this dataset and then commentaries highlighting insights and lessons drawn from this original research.

The Imposition Of Constitutional Rights, Alvin Padilla-Babilonia

Faculty Publications

One of the central principles of constitutionalism is that citizenship stands for equal rights under the law. According to this ideal, a U.S. citizen living in Puerto Rico or Guam should have the same constitutional rights as a citizen living on the mainland. However, throughout U.S. history, constitutional rights have been neither uniform nor centralized. While constitutional rights held im- portance, they coexisted with ideals of democratic self-governance and legal pluralism. Today, Supreme Court justices and legal scholars argue that all constitutional rights should apply in the territories. This view upholds citizenship, equal rights, and the rule of law. But …

Data Package Supporting Research On Personalized Learning Path Problem Derived From The Cognitive Theory Of Multimedia Learning, Sean A. Mochocki, Mark Reith

Faculty Publications

Personalized Learning Paths (PLP)s are sequences of learning materials and activities that are designed to deliver personalized education to students. Unfortunately, PLPs are often defined and implemented based on faulty cognitive science practices. The PLP research community may benefit from a problem domain and data set that is derived from a scientifically supported cognitive science discipline. This data is published to support the paper, “A Two-Stage Multi-Objective Personalized Learning Path Problem Based on the Cognitive Theory of Multimedia Learning.” This data set includes the data used in this paper, the questionnaire used to gather learner profile data, and the python …

Testing For Normality In Regression Models: Mistakes Abound (But May Not Matter), Stephen Midway, J. Wilson White

Faculty Publications

This study examines the misuse of normality tests in linear regression within ecology and biology, focusing on common misconceptions. A bibliometric review found that over 70% of ecology papers and 90% of biology papers incorrectly applied normality tests to raw data instead of model residuals. To assess the impact of this error, we simulated datasets with normal, interval, and skewed distributions across various sample and effect sizes. We compared statistical power between two approaches: testing the whole dataset for normality (incorrect) versus testing model residuals (correct) to determine whether to use a parametric (t-test) or nonparametric (Mann-Whitney U test) method. …

‘I Feel Like The Most Important Thing Is To Ensure That Women Feel Included…’: Immigrant Women’S Experiences Of Integration And Gender Equality In Iceland During Times Of Crisis, Marya Rozanova-Smith, Embla Eir Oddsdóttir, Andrey N. Petrov

Faculty Publications

Enabling gender equality by empowering women to fully engage in modern society is fundamental for building resilient and sustainable communities. While Iceland is recognized as a global leader in gender equality, the experiences of various immigrant groups can differ considerably, especially during crises such as the COVID-19 pandemic and recovery. Given the rapid increase in the immigrant population in Iceland, it is crucial to gain a deeper understanding of the processes surrounding immigrant women’s integration strategies, with an emphasis on gender equality through the lens of intersectionality. The main objective of this qualitative study is to explore the gendered impacts …

Compensating Regulatory Losers, Todd S. Aagaard

Faculty Publications

Every change in government regulation creates benefits and burdens that fall unequally on the population. This unequal distribution raises the question of whether fairness requires compensating those who bear regulatory costs—what is known as the “compensation problem.” The extensive body of scholarship addressing the compensation problem tends to focus only on the burdens of regulatory compliance and ignores the burdens of injuries left unaddressed by regulation. The effect of this differential treatment is to treat past regulatory windfalls as permanent entitlements and to omit from the analysis equally deserving regulatory losers who have suffered the consequences of unregulated harms. This …

Academic And Cerebrovascular Outcomes After Neurodevelopmental Screening In Sickle Cell Disease: A Longitudinal Cohort Study, Sarah E. Bills, Jeffrey Schatz, Elizabeth Gillooly, Julia D. Johnston, A. Lauren Waters, Alyssa M. Schlenz

Faculty Publications

Aim

To assess the predictive validity of neurodevelopmental screening in toddlers and preschool children with sickle cell disease (SCD) using the Ages and Stages Questionnaire (ASQ). We expected screening in preschool children to predict academic problems in elementary school and future stroke risk.

Method

Using a longitudinal cohort design, academic problems (e.g. grade retention, failing a subject) and increases in stroke risk (e.g. abnormal transcranial Doppler exam) were assessed for a 6-year period after neurodevelopmental screening in 2-year-olds (‘toddlers’) and 4-year-olds (‘preschool children’) using medical record review, which included annual information from parents about school functioning. Biopsychosocial variables were examined …

Trump And The Us Energy Transition, Conor M. Harrison

Faculty Publications

The US electricity grid has seen a rapid increase in the amount of renewable energy over the last decade, with many renewable advocates viewing the Inflation Reduction Act of 2022 as the catalyst to move the grid towards 100% clean energy. The 2024 elections, however, have significantly muddied the path. In this commentary, I posit what the Trump administration—and related Republican control of both houses of the US Congress—means for the US electricity system. I begin by briefly outlining the contours of federal and state electricity governance, the design of Inflation Reduction Act, the existing drivers of renewable energy growth …

Deportations And Latino Segregation: The Residential Impacts Of Interior Immigration Enforcement, Matthew Hall, Jacob S. Rugh, Hao Liang

Faculty Publications

The shift of immigration enforcement to local jurisdictions has intensified localized patterns of anti-immigrant sentiment, enabling the system of mass deportation to expand at an unprecedented scale. This study examines the effects of 287 (g) agreements, which empower local law enforcement to enforce immigration laws, on Latino residential segregation. Using a quasi-experimental design that compares counties implementing 287 (g) with those that applied but did not implement, we find that these policies significantly slowed declines in Hispanic-white segregation, particularly in early-adopting Southern counties where enforcement was most aggressive. We find no evidence that the program altered patterns of segregation for …

Barriers To Using Bicycle Workstations In A Campus Library, Catherine Wong, Cynthia Ferrara, Robyn Lebowitz, Hayleigh Duggan

Faculty Publications

Background

The purpose of this study is to assess campus awareness and attitudes toward bicycle workstations in the library at a small, private college in the New England region of the United States.

Methods

Two recumbent and two Expresso bicycle workstations were placed in public areas of the college library. A short online survey with multiple choice and open-ended questions was designed specifically for the study. Members of the campus community were invited to complete the survey, as approved by the Institutional Review Board. Themes were identified for open-ended questions. Answers were sorted using designated themes.

Results

Ninety-five people completed …

Enhancing Self-Efficacy For Engagement With Diversity, Equity, And Inclusion Initiatives: Evaluation Of A Seven-Day Immersive Pilot Program In A College Of Education, Health, And Human Sciences, Jennifer M. Jabson Tree, Stefanie Benjamin, Dorian L. Mccoy Ph.D.

Faculty Publications

Colleges of health, human sciences, and education are often administratively organized to include a diverse array of human sciences departments that share roots in social justice and a commitment to advancing equity and inclusion. Despite espoused commitments to equity and inclusion, they frequently struggle to achieve the changes necessary for advancing equity, and inclusion principles across policies, practices, procedures, and units. We implemented and evaluated a 7-day, total immersion, 56-h, educational program entitled the “Social Justice Institute” (SJI) for two cohorts of faculty, staff, and administrators to develop self-efficacy to intervene in systemic oppression in their academic units. SJI delivered …

Research Supporting Evangelism, Williams Kwasi Peprah

Faculty Publications

No abstract provided.

“I Think Even In Challenging Times We Can Still Be Uplifting”: Indigenous Women’S Experiences Of Resilience To The Covid-19 Pandemic In Alaska, Marya Rozanova-Smith, Charlene Apok, Andrey N. Petrov

Faculty Publications

During the COVID-19 pandemic, Alaska communities faced an extremely challenging situation given their socioeconomic, cultural, and demographic characteristics, as well as issues related to remoteness and colonial legacy. This paper seeks to advance the understanding of the gendered impacts and implications of crises like the COVID-19 pandemic on Indigenous women in Alaskan urban and rural communities through a resilience lens. The paper addresses two primary research questions: (1) What are the impacts of the COVID-19 pandemic on Indigenous women in urban and rural Alaska, and specifically what are the gendered implications in the personal, sociocultural, and economic domains? (2) What …

Founded In Faith. Forward In Mission!: 2024: A Year Of Celebration And Commitment, John Wesley Taylor V

Faculty Publications

No abstract provided.

Global Ionospheric F Region Parameters From Gnss-Pod Limb Measurements: Evaluations And Comparisons With Two Empirical Models - Iri-2020 And Nequick-2, Nimalan Swarnalingam, Dong L. Wu, Dieter Bilitza, Daniel J. Emmons, Cornelius Csar Jude H. Salinas, Artem Smirnov, Yenca Migoya-Oru

Faculty Publications

An optimal estimation (OE) technique has recently been developed for F region electron density (Ne) using Global Navigation Satellite System (GNSS) limb sounding on low Earth orbit (LEO) satellites (COSMIC-2, Spire, and FengYun-3). This method provides unprecedented spatiotemporal sampling for global monthly Ne climatology within 100–500 km in 2 hr intervals. The global dataset, collected during mid to moderately high solar activity, is compared with leading models: IRI-2020 and NeQuick-2. Diurnal variations in summer, winter, and equinoctial months are examined for the F2-layer peak, as well as the topside and bottomside of the F region. The observed and modeled NmF2 …

Scalable Cyber-Physical Testbed For Cybersecurity Evaluation Of Synchrophasors In Power Systems, Shuvangkar Chandra Das, Tuyen Vu, Hebert L. Ginn Iii

Faculty Publications

This paper presents a synchrophasor-based real-time cyber-physical power system testbed with a novel security evaluation tool, pySynphasor, that can emulate different real attack scenarios on the phasor measurement unit (PMU). The testbed focuses on real-time cyber-security emulation using different components, including a real-time digital simulator, virtual machines (VM), a communication network emulator, and a packet manipulation tool. The script-based VM deployment and software-defined network emulation facilitate a highly scalable cyber-physical testbed, which enables emulations of a real power system under different attack scenarios such as address resolution protocol (ARP) poisoning attack, man-in-the-middle (MITM) attack, false data injection attack (FDIA), and …

Sexually Transmitted Infection (Sti) Incidence And Risk Factors Among People With Hiv (Pwh): Insights From A 13-Year Cohort Study In South Carolina, Salome-Joelle Gass, Shujie Chen, Jiajia Zhang Ph.D., Bankole Olatosi

Faculty Publications

The Ending the HIV Epidemic (EHE) initiative aims to reduce new HIV infections by 90% by 2030 in the United States (US). However, rising sexually transmitted infection (STI) rates exacerbate the bidirectional infection risk between HIV and STIs. Most research on STIs among people with HIV (PWH) has focused on high-risk groups, resulting in limited data on broader populations. This study addresses that gap by examining the incidence and risk factors for gonorrhea, chlamydia, and syphilis in a statewide cohort of PWH in South Carolina. Data from South Carolina’s HIV and STI surveillance systems were linked, and all PWH aged …

Promoting Social Inclusion Through Sport: A Case Study Of Uyghur Youth In China, Hongxin Li, Yunchao Bai, John Nauright

Faculty Publications

This study examines the role of sports as a means of promoting social inclusion among Uyghur youth in China, drawing upon social inclusion theory. Utilizing a qualitative case study methodology, we explored the perspectives of Uyghur youth athletes to gain insight into the challenges they face in achieving social inclusion without feeling “othered” or excluded. Data analysis followed an inductive grounded theory approach, identifying first‐order concepts, second‐order themes, and aggregate theoretical dimensions. Our findings reveal that social inclusion of Uyghur youth through sports participation is influenced by multiple factors, including language barriers, stereotypes, cultural differences, high expectations, and government policies. …

Environmental Risk And Alpha-Gal Syndrome (Ags) In The Mid-Atlantic United States, Brandon D. Hollingsworth Ph.D., Margaret Wiener, Dana A. Giandimenico, Scott P. Commins, Ross M. Boyce

Faculty Publications

Alpha-gal syndrome (AGS), commonly referred to as the tick bite red meat allergy, has been reported worldwide with the number of suspected cases in the United States increasing from 24 in 2009 to over 34,000 in 2019. Within the US, AGS is associated with the bite of two tick species, Amblyomma americanum and Ixodes scapularis, and has particularly high incidence rates in the mid-Atlantic region. Because AGS is associated with tick bites, the risk of developing AGS is affected by the environment individuals visit. Despite this, as well as the numerous studies associating the environment with Am. americanum, …

Effect Of Precursors On Trimetallic Ruthenium-Based Catalysts Supported On Γ‑Al2O3 Pellets For Low-Temperature Ammonia Decomposition, Christopher J. Koch, Jennifer Naglic, Logan Kearney, Daniel Clairmonte, Binod Rai, Jochen A. Lauterbach, Lucas M. Angelette, Tyler Guin

Faculty Publications

Ammonia is a promising candidate as a liquid hydrogen energy storage medium, but it requires catalytic decomposition (ammonia cracking) to regenerate hydrogen. Recently developed trimetallic ruthenium−potassium-promoter (RuKM) ammonia decomposition catalysts have exceptionally low ammonia decomposition temperatures, able to perform the decomposition as low as 250 °C, which is significantly lower than other known catalysts that require temperatures above 500 °C. However, the effects of the RuKM precursor on the catalytic activity have not been investigated. We report the observed differences of 3% ruthenium/12% potassium/1% yttrium (RuKY) catalysts on γ-alumina synthesized from chloride-, nitrate-, and acetate-based precursors. Catalysts synthesized from chloride-based …

Crashing The Party: How Textualism And Legislative History Can Work Together, John Cannan

Faculty Publications

Textualists must moderate their distaste for legislative history and acknowledge the role of congressional sources in statutory interpretation—even those they themselves approve of. Doing so would enhance their statutory analyses. Decisions arising from 2016 litigation by hospitals against the U.S. Department of Health and Human Services, culminating in Azar v. Allina Health Servs., 139 S. Ct. 1804, 204 L. Ed. 2d 139 (2019), demonstrate how textualist inflexibility can undermine their own principles. For example, notable advocates of that interpretive school—then-Judge Brett Kavanaugh and Justice Neil Gorsuch—overlooked statutory text, which they so highly prize, in reaching their determinations. Textualists often describe …

Ligo Detector Characterization In The First Half Of The Fourth Observing Run, S. Soni, B. K. Berger, D. Davis, F. Di Renzo, A. Effler, T. A. Ferreira, J. Glanzer, E. Goetz, G. González, A. Helmling-Cornell, B. Hughey, R. Huxford, B. Mannix, G. Mo, D. Nandi, A. Neunzert, S. Nichols, K. Pham, A. I. Renzini, R. M.S. Schofield, A. Stuver, M. Trevor, S. Álvarez-López, R. Beda, C. P.L. Berry, S. Bhuiyan, L. Blagg, R. Bruntz, S. Callos, M. Chan, P. Charlton, N. Christensen, G. Connolly

Faculty Publications

Progress in gravitational-wave (GW) astronomy depends upon having sensitive detectors with good data quality. Since the end of the Laser Interferometer Gravitational-Wave Observatory-Virgo-KAGRA third Observing run in March 2020, detector-characterization efforts have lead to increased sensitivity of the detectors, swifter validation of GW candidates and improved tools used for data-quality products. In this article, we discuss these efforts in detail and their impact on our ability to detect and study GWs. These include the multiple instrumental investigations that led to reduction in transient noise, along with the work to improve software tools used to examine the detectors data-quality. We end …

Cost-Effectiveness Analysis Of Aducanumab Versus Placebo For Patients With Mild Cognitive Impairment And Mild Alzheimer’S Disease, Xiaomo Xiong, Gang Lv, Jacob Jordan King, Minghui Li, Jing Yuan, Z Kevin Lu

Faculty Publications

Objectives To assess the cost-effectiveness of aducanumab at its updated price for treating patients with mild cognitive impairment (MCI) and mild Alzheimer’s disease (AD).

Design Cost-effectiveness analysis.

Settings A five-state Markov model was constructed using 10 000 virtual patients to assess the cost-effectiveness of aducanumab from the perspective of the US healthcare system. The model employed a one-year cycle time and a lifetime time horizon. Transition probabilities and mortality rates were derived from a literature review. To address uncertainty and generalise the base case results, both one-way and probabilistic sensitivity analyses were conducted.

Participants 10 000 virtual patients with MCI …