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X-Ray Crystallographic Identification Of A Protein-Binding Site For Both All-Trans- And 9-Cis-Retinoic Acid, Marcia E. Newcomer, R. Steven Pappas, David E. Ong Oct 1993

X-Ray Crystallographic Identification Of A Protein-Binding Site For Both All-Trans- And 9-Cis-Retinoic Acid, Marcia E. Newcomer, R. Steven Pappas, David E. Ong

Faculty Publications

The elucidation of how a protein-binding site might specifically recognize both the all-trans and 9-cis isomers of retinoic acid is of particular interest because of the recently discovered binding specificities of the nuclear receptors for retinoic acid. Two families of nuclear receptors for retinoic acid have been described, which are designated RAR (for retinoic acid receptor) and RXR (for retinoid-X receptor). The RXR family of receptors is specific for 9-cis-retinoic acid, whereas the RAR-type receptor is activated by either 9-cis- or all-transretinoic acid. During the x-ray structure determination of a secreted epididymal retinoic acid-binding protein, with and without retinoic acid, …

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The Bible, Congregational Leaders, And Moral Conversation, Patrick R. Keifert Oct 1993

The Bible, Congregational Leaders, And Moral Conversation, Patrick R. Keifert

Faculty Publications

No matter how old an observation, it remains nonetheless true: We tend to remember the preacher more than the sermon, the teacher more than the lecture. Perhaps that is all we have recently learned in a preliminary study of twelve congregations in the Southwestern Minnesota Synod of the Evangelical Lutheran Church in America (SW Synod). However, there are some nuances that raise very important questions for theological education in seminaries and congregations—and, even more important, insights for the role of leaders and their use of Scripture in the moral conversations within congregations. In short, we have found from dozens of …

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Foreword: Elected Branch Influences In Constitutional Decisionmaking, Neal Devins Oct 1993

Foreword: Elected Branch Influences In Constitutional Decisionmaking, Neal Devins

Faculty Publications

No abstract provided.

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Congress, The Fcc, And The Search For The Public Trustee, Neal Devins Oct 1993

Congress, The Fcc, And The Search For The Public Trustee, Neal Devins

Faculty Publications

No abstract provided.

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Surveying Knowledge And Skills In The Health Sciences: Results And Implications, Fred W. Roper Oct 1993

Surveying Knowledge And Skills In The Health Sciences: Results And Implications, Fred W. Roper

Faculty Publications

http://www.ncbi.nlm.nih.gov/pmc/journals/72/ ©1993 Medical Library Association

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Platform For Change: Medical Library Education In The Information Age: Introduction, Fred W. Roper, M Kent Mayfield Oct 1993

Platform For Change: Medical Library Education In The Information Age: Introduction, Fred W. Roper, M Kent Mayfield

Faculty Publications

No abstract provided.

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Structure Of The Epididymal Retinoic Acid Binding Protein At 2.1 Å Resolution, Marcia E. Newcomer Sep 1993

Structure Of The Epididymal Retinoic Acid Binding Protein At 2.1 Å Resolution, Marcia E. Newcomer

Faculty Publications

Background: Androgen-dependent proteins in the lumen of the epididymis are required for sperm maturation. One of these is a retinoic acid binding protein, E-RABP, which binds both all-trans and 9-cis retinoic acid. The other retinoid-binding proteins whose structures are known do not bind 9-cis retinoids. Results: We describe the X-ray structure determination of E-RABP with and without bound ligand. The ligand binds deep in the β-barrel of the protein, the β-ionone ring innermost. The binding site, like the ligand, is amphipathic and the deepest part of the cavity is formed by a ring of aromatic amino acids. The isoprene tail …

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Physical Inactivity. Workshop V. Aha Prevention Conference Iii. Behavior Change And Compliance: Keys To Improving Cardiovascular Health, Steven N. Blair, Kenneth E. Powell, Terry L. Bazzarre, James L. Early, Leonard H. Epstein, Lawrence W. Green, Sally S. Harris, William L. Haskell, Abby C. King, Jeffrey Koplan, Bess H. Marcus, Ralph S. Paffenbarger Jr., Kimberly K. Yeager Sep 1993

Physical Inactivity. Workshop V. Aha Prevention Conference Iii. Behavior Change And Compliance: Keys To Improving Cardiovascular Health, Steven N. Blair, Kenneth E. Powell, Terry L. Bazzarre, James L. Early, Leonard H. Epstein, Lawrence W. Green, Sally S. Harris, William L. Haskell, Abby C. King, Jeffrey Koplan, Bess H. Marcus, Ralph S. Paffenbarger Jr., Kimberly K. Yeager

Faculty Publications

No abstract provided.

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'Death And Taxes' And Hypocrisy, John W. Lee Sep 1993

'Death And Taxes' And Hypocrisy, John W. Lee

Faculty Publications

Professor Lee finds the "death and taxes" poem by Rep. Ewing hypocritical for several reasons. He notes that the poem is derived from a 1920s populist attack on Treasury Secretary Mellon for cutting taxes on the rich in the name of trickle-down economics while relying on regressive excise taxes on the masses -- an attack similar to that waged by then-Governor Clinton during the 1992 presidential campaign. Further, says Lee, the Bush administration displayed more of a preference for regressive excise taxes than the Clinton plan, whose reliance in part on consumption taxes appears a consequence of 25 years of …

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Radially Symmetrical Flow Of Reacting Liquid With Changing Viscosity, S.E. Solovyov, V.A. Volpert, S.P. Davytan Aug 1993

Radially Symmetrical Flow Of Reacting Liquid With Changing Viscosity, S.E. Solovyov, V.A. Volpert, S.P. Davytan

Faculty Publications

Frontal regimens for one-dimensional flow of reacting liquid with changing viscosity are studied. Stationary solutions are investigated for the case of narrow reaction zones that shrink to a front. The results of numerical solution of the nonstationary problem are presented. Complex oscillations resulting from period-doubling bifurcations are found.

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Low‐Cost Technique For Preparing N‐Sb2S3/P‐Si Heterojunction Solar Cells, O. Savadogo, K. C. Mandal Jul 1993

Low‐Cost Technique For Preparing N‐Sb2S3/P‐Si Heterojunction Solar Cells, O. Savadogo, K. C. Mandal

Faculty Publications

No abstract provided.

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High-Order Harmonic Generation With Short-Pulse Lasers, Kenneth J. Schafer, Jeffrey L. Krause, Kenneth C. Kulander Jul 1993

High-Order Harmonic Generation With Short-Pulse Lasers, Kenneth J. Schafer, Jeffrey L. Krause, Kenneth C. Kulander

Faculty Publications

Recent progress in the understanding of high-order harmonic conversion from atoms and ions exposed to high-intensity, short-pulse optical lasers is reviewed. We find that ions can produce harmonics comparable in strength to those obtained from neutral atoms, and that the emission extends to much higher order. Simple scaling laws for the strength of the harmonic emission and the maximum observable harmonic are suggested. These results imply that the photoemission observed in recent experiments in helium and neon contains contributions from ions as well as neutrals.

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Should The Characteristics Of Victims And Criminals Count? Payne V. Tennessee And Two Views Of Efficient Punishment, David D. Friedman Jul 1993

Should The Characteristics Of Victims And Criminals Count? Payne V. Tennessee And Two Views Of Efficient Punishment, David D. Friedman

Faculty Publications

No abstract provided.

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Linking Teacher Educators, Knowledge, And The Quality Of Practice In Schools, Murrary F. Mitchell Jul 1993

Linking Teacher Educators, Knowledge, And The Quality Of Practice In Schools, Murrary F. Mitchell

Faculty Publications

Children in this country are entrusted to teachers in schools for 5 hours a day, 5 days a week, approximately 36 weeks a year, for 12 to 13 years. Citizens concerned with the future want to know if the children of today are being prepared for the world of tomorrow. Parents want to know what is being done to and for their sons and daughters. And in these times of financial cutbacks, taxpayers want to know where their tax dollars are going. There is widespread belief that schools in general, and teaching in particular, should be much better today than …

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Three Points Of Great Height On Elliptic Curves, Andrew Bremner, Duncan A. Buell Jul 1993

Three Points Of Great Height On Elliptic Curves, Andrew Bremner, Duncan A. Buell

Faculty Publications

We give three elliptic curves whose generators have great height, demonstrating along the way a moderately efficient method for finding such points.

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Frontier Democracy: The Turner Thesis Revisited, Lacy K. Ford, Jr. Jul 1993

Frontier Democracy: The Turner Thesis Revisited, Lacy K. Ford, Jr.

Faculty Publications

No abstract provided.

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The Legal Significance Of Gestation, Larry I. Palmer Jul 1993

The Legal Significance Of Gestation, Larry I. Palmer

Faculty Publications

No abstract provided.

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Congressional Procedure And Statutory Interpretation, Larry Evans, Jarrell Wright, Neal Devins Jul 1993

Congressional Procedure And Statutory Interpretation, Larry Evans, Jarrell Wright, Neal Devins

Faculty Publications

No abstract provided.

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The Effect Of The Postdivorce Relationship On Paternal Involvement: A Longitudinal Analysis, Constance R. Ahrons, Richard B. Miller Jul 1993

The Effect Of The Postdivorce Relationship On Paternal Involvement: A Longitudinal Analysis, Constance R. Ahrons, Richard B. Miller

Faculty Publications

Longitudinal analyses of data from 64 pairs of former spouses indicate that the quality of their postdivorce relationship had a significant impact on fathers' involvement with their children. The strength of the influence declined over time, however, as the patterns of interaction in the reorganized binuclear family became more stable.

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Formation Of O-Tyrosine And Dityrosine In Proteins During Radiolytic And Metal-Catalyzed Oxidation, Thomas G. Huggins, Mary C. Wells-Knecht, Nicholas A. Detorie, John W. Baynes, Suzanna R. Thorpe Jun 1993

Formation Of O-Tyrosine And Dityrosine In Proteins During Radiolytic And Metal-Catalyzed Oxidation, Thomas G. Huggins, Mary C. Wells-Knecht, Nicholas A. Detorie, John W. Baynes, Suzanna R. Thorpe

Faculty Publications

To evaluate their usefulness as chemical indicators of cumulative oxidative damage to proteins, we studied the kinetics and extent of formation of ortho-tyrosine (0-Tyr), dityrosine (DT), and dityrosine-like fluorescence (Ex = 3 17 nm, E,,, = 407 nm) in the model proteins RNase and lysozyme exposed to radiolytic and metalcatalyzed (H20z/Cu2+) oxidation (MCO). Although there were protein-dependent differences, o-Tyr, DT, and fluorescence increased coordinately during oxidation of the proteins in both oxidation systems. The contribution of DT to total dityrosine-like fluorescence in oxidized proteins varied from 2-10070, depending on the protein, type of oxidation, and extent of oxidative damage. In …

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Oxidized Amino Acids In Lens Protein With Age: Measurement Of O-Tyrosine And Dityrosine In The Aging Human Lens, Mary C. Wells-Knect, Thomas G. Huggins, Daniel G. Dyer, Suzanne R. Thorpe, John W. Baynes Jun 1993

Oxidized Amino Acids In Lens Protein With Age: Measurement Of O-Tyrosine And Dityrosine In The Aging Human Lens, Mary C. Wells-Knect, Thomas G. Huggins, Daniel G. Dyer, Suzanne R. Thorpe, John W. Baynes

Faculty Publications

The concentrations of ortho-tyrosine (o-Tyr) and dityrosine (DT) were measured in noncataractous human lenses in order to assess the role of proteinoxidation reactions in the aging of lens proteins. The measurements were conducted by selected ion monitoring-gas chromatography/mass spectrometry using deuterium-labeled internal standards, which provided both high sensitivity and specificity for the quantitation of o-Tyr and DT. Between ages 1 and 78 years, the o-Tyr concentration in lens proteins varied from 0.3 to 0.9 mmol of o-Tyr/mol of Phe (n = 19), while DT ranged from 1 to 3 mumol of DT/mol of Tyr (n = 30). There were no …

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President Clinton's Capital Gains Proposals, John W. Lee Jun 1993

President Clinton's Capital Gains Proposals, John W. Lee

Faculty Publications

Professor Lee believes that the generic capital gains rate should not be increased over 28 percent for revenue and political reasons. But to reflect that, on the average, capital gains realized by middle-income families consists entirely of inflation gain, while half of the capital gain realized at the 31- percent bracket and above consists of economic gain, increasing to 80-percent economic at the very top, he argues that a greater exclusion should be provided at the 28- and 15-percent brackets, either by a "progressive schedule" or by a $3,500 annual exclusion. To strengthen the political base for increasing the top …

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Accumulation Of Maillard Reaction Products In Skin Collagen In Diabetes And Aging, Daniel G. Dyer, John A. Dunn, Suzanne R. Thorpe, Karen E. Bailie, Timothy L. Lyons, David R. Mccance, John W. Baynes Jun 1993

Accumulation Of Maillard Reaction Products In Skin Collagen In Diabetes And Aging, Daniel G. Dyer, John A. Dunn, Suzanne R. Thorpe, Karen E. Bailie, Timothy L. Lyons, David R. Mccance, John W. Baynes

Faculty Publications

To investigate the contribution of glycation and oxidation reactions to the modification of insoluble collagen in aging and diabetes, Maillard reaction products were measured in skin collagen from 39 type 1 diabetic patients and 52 nondiabetic control subjects. Compounds studied included fructoselysine (FL), the initial glycation product, and the glycoxidation products, N epsilon-(carboxymethyl) lysine (CML) and pentosidine, formed during later Maillard reactions. Collagen-linked fluorescence was also studied. In nondiabetic subjects, glycation of collagen (FL content) increased only 33% between 20 and 85 yr of age. In contrast, CML, pentosidine and fluorescence increased five-fold, correlating strongly with age. In diabetic patients, …

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Maillard Reaction Products And Their Relation To Complications In Insulin-Dependent Diabetes Mellitus, David R. Mccance, Daniel G. Dryer, John A. Dunn, Karen E. Bailie, Suzanne R. Thorpe, John W. Baynes, Timothy J. Lyons Jun 1993

Maillard Reaction Products And Their Relation To Complications In Insulin-Dependent Diabetes Mellitus, David R. Mccance, Daniel G. Dryer, John A. Dunn, Karen E. Bailie, Suzanne R. Thorpe, John W. Baynes, Timothy J. Lyons

Faculty Publications

Glycation, oxidation, and browning of proteins have all been implicated in the development of diabetic complications. We measured the initial Amadori adduct, fructoselysine (FL); two Maillard products, N epsilon-(carboxymethyl) lysine (CML) and pentosidine; and fluorescence (excitation = 328 nm, emission = 378 nm) in skin collagen from 39 type 1 diabetic patients (aged 41.5 +/- 15.3 [17-73] yr; duration of diabetes 17.9 +/- 11.5 [0-46] yr, [mean +/- SD, range]). The measurements were related to the presence of background (n = 9) or proliferative (n = 16) retinopathy; early nephropathy (24-h albumin excretion rate [AER24] > or = 20 micrograms/min; n …

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An Exploration Of High-Risk Leisure Consumption Through Skydiving, Richard L. Celsi, Randall L. Rose, Thomas W. Leigh Jun 1993

An Exploration Of High-Risk Leisure Consumption Through Skydiving, Richard L. Celsi, Randall L. Rose, Thomas W. Leigh

Faculty Publications

A sociocultural approach is used to explore voluntary high-risk consumption Specifically, we examine the dynamics of individuals' motives, risk perceptions, and benefit/cost outcomes of participation in increasingly popular high-risk leisure activities such as skydiving, climbing, and BASE jumping (parachuting from fixed objects). An ethnography of a skydiving subculture provides the primary empirical data. We propose an extended dramatic model that explains both macroenvironmental and inter- and intrapersonal influences and motives for high-risk consumption. Key findings indicate (1) an evolution of motives that explains initial and continuing participation in high-risk activities and (2) a coinciding evolution of risk acculturation that leads …

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The Semantics Of Certainty In Quechua And Its Implications For A Cultural Epistemology, Janis B. Nuckolls Jun 1993

The Semantics Of Certainty In Quechua And Its Implications For A Cultural Epistemology, Janis B. Nuckolls

Faculty Publications

This article contributes to attempts on the part of Quechua scholars to understand the evidential system of this language family, and thereby paves the way for a more complex understanding of Quechua speakers' language and culture. The author opposes the position that the most general meaning of the -mi suffix is to indicate a direct or first-hand experience; and she holds that specific claims about Quechua speakers' epistemological orientations, based on such an analysis, cannot be supported. Evidence from speakers' use of -mi indicates that it encodes two paradigmatic contrasts: one is status-like or modal, the other evidential. The patterning …

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Another Cautionary Note On Interpreting Regression Results In Family Research: A Comment On Peterson And Gerson (1992), Alan J. Hawkins, Joseph A. Olsen, Richard R. Peterson, Kathleen Gerson May 1993

Another Cautionary Note On Interpreting Regression Results In Family Research: A Comment On Peterson And Gerson (1992), Alan J. Hawkins, Joseph A. Olsen, Richard R. Peterson, Kathleen Gerson

Faculty Publications

Occasionally in the family literature we receive reminders to be cautious about our interpretations of regressions results (e.g., Glenn & Kramer, 1985; Glenn & Shelton, 1983). After all, regression results are stated in the language of mathematics. We must be careful when we translate from the language of mathematics, which is blind to the human situation being represented by the numbers, into language that is meaningful in the human context. This brief not critiques the interpretation of regression results in an article by Peterson and Gerson (1992) that appeared in a recent issue of the Journal of Marriage and the …

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Discursive Democracy: Politics, Policy, And Political Science, Edward M. Wheat May 1993

Discursive Democracy: Politics, Policy, And Political Science, Edward M. Wheat

Faculty Publications

No abstract provided.

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Rule Of Law In Legal And Economic Theory, Noel B. Reynolds Apr 1993

Rule Of Law In Legal And Economic Theory, Noel B. Reynolds

Faculty Publications

Legal positivism, the leading version of legal theory, has shown that a concentration on the meanings and logical relations of legal concepts, however much supplemented by intuition, common sense and legal experience, is not adequate to make full sense out of the human experience of law, and the traditional understandings of legal obligation and rule of law in particular. However, modern economic science has advanced a radically individualistic theoretical approach which has propelled economics to the fore as the most successful of the social sciences. And its basic theoretical stance is proving both attractive and adaptable to all the other …

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Initial Study Of Deep Inelastic Scattering With Zeus At Hera, M. Derrick, D. Krakauer, S. Magill, B. Musgrave, J. Repond, S. Repond, R. Stanek, R. L. Talaga, J. Thron, F. Arzarello, R. Ayad, G. Barbagli, G. Bari, M. Basile, L. Bellagamba, D. Boscherini, A. Bruni, G. Bruni, P. Bruni, G. Cara Romeo, G. Castellini, M. Chiarini, L. Cifarelli, F. Cindolo, F. Ciralli, A. Contin, S. D'Auria, C. Del Papa, F. Frasconi, P. Giusti, G. Iacobucci, G. Laurenti, G. Levi Apr 1993

Initial Study Of Deep Inelastic Scattering With Zeus At Hera, M. Derrick, D. Krakauer, S. Magill, B. Musgrave, J. Repond, S. Repond, R. Stanek, R. L. Talaga, J. Thron, F. Arzarello, R. Ayad, G. Barbagli, G. Bari, M. Basile, L. Bellagamba, D. Boscherini, A. Bruni, G. Bruni, P. Bruni, G. Cara Romeo, G. Castellini, M. Chiarini, L. Cifarelli, F. Cindolo, F. Ciralli, A. Contin, S. D'Auria, C. Del Papa, F. Frasconi, P. Giusti, G. Iacobucci, G. Laurenti, G. Levi

Faculty Publications

Results are presented on neutral current, deep inelastic scattering measured in collisions of 26.7 GeV electrons and 820 GeV protons. The events typically populate a range in Q2 from 10 to 100 GeV2. The values of x extend down to x ∼ 10-4 which is two orders of magnitude lower than previously measured at such Q2 values in fixed target experiments. The measured cross sections are in accord with the extrapolations of current parametrisations of parton distributions. © 1993.

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