Digital Commons Network^™

Synergistic In Vitro Antiviral Effect Of Combinations Of Ivermectin, Essential Oils, And 18-(Phthalimid-2-Yl)Ferruginol Against Arboviruses And Herpesvirus, Liliana Betancur-Galvis, Orlando José Jimenez-Jarava, Fatima Rivas, William E. Mendoza-Hernández, Miguel A. González-Cardenete

Faculty Publications

Combining antiviral drugs with different mechanisms of action can help prevent the development of resistance by attacking the infectious agent through multiple pathways. Additionally, by using faster and more economical screening methods, effective synergistic drug candidates can be rapidly identified, facilitating faster paths to clinical testing. In this work, a rapid method was standardized to identify possible synergisms from drug combinations. We analyzed the possible reduction in the antiviral effective concentration of drugs already approved by the FDA, such as ivermectin (IVM), ribavirin (RIBA), and acyclovir (ACV) against Zika virus (ZIKV), Chikungunya virus (CHIKV), and herpes virus type 2 (HHV-2). …

Looking Back To Look Forward: Exploring Crenshaw’S Political, Structural, And Representational Intersectionality In Sport, Allison Anders Ph.D., James M. Devita, Leslee A. Fisher, Chris Corr, Christina L. Myers

Faculty Publications

Engaging with Kimberlé Crenshaw’s concept of intersectionality, the authors (re)turn to its genesis in critical race theory (CRT) and specifically, its forms of structural intersectionality, political intersectionality, and representational intersectionality. Discussing each form in relation to contemporary issues in sport that Black women and women of Color navigate, they argue that Crenshaw’s intersectionality provides additional compelling layers of engagement with existing intersectional scholarship and scholarship about activism in sport, invites structural and discursive change through intersectional policies and practice, and promotes coalition building toward intersectional racial justice in sport.

Effect Of Sampling Method On Detection Of The Equine Uterine Microbiome During Estrus, B. A. Heil, M. Van Heule, S. K. Thompson, T. A. Kearns, E. L. Oberhaus, G. King, P. Daels, P. Dini, J. L. Sones

Faculty Publications

Bacterial endometritis is among the most common causes of subfertility in mares. It has a major economic impact on the equine breeding industry. The sensitivity of detecting uterine microbes using culture-based methods, irrespective of the sample collection method, double-guarded endometrial swab, endometrial biopsy, or uterine low-volume lavage (LVL), is low. Therefore, equine bacterial endometritis often goes undiagnosed. Sixteen individual mares were enrolled, and an endometrial sample was obtained using each method from all mares. After trimming, quality control and decontamination, 3824 amplicon sequence variants were detected in the dataset. We found using 16S rRNA sequencing that the equine uterus harbors …

Editorial Introduction: Exploring Policy Theories, Narratives, And Policing, Geoboo Song, Melissa K. Merry, Holly L. Peterson, Davor Mondom, Briana Huett, Izehi Oriaghan, Creed Tumlison, Camille Gilmore, Gwen Arnold, Aaron Smith-Walter, Saba Siddiki, Heasun Choi

Faculty Publications

No abstract provided.

Technology Specificity And Equitable Access To Pharmaceuticals, Ana Santos Rutschman

Faculty Publications

Current models of production of pharmaceuticals, particularly those dependent on intellectual property (and adjacent) protections, often contribute to the highly asymmetrical and inequitable distribution of resulting outputs. These problems are especially acute when emerging pathogens cause transnational public health crises in which there is concurrent demand for the same medicines in both lower- and higher-income countries, with populations in the Global South getting very limited timely access, if any, to preventatives and life-saving medicines—even when an outbreak disproportionately affects populations in these very countries.

This essay examines an under-theorized and under-explored way to help correct this historical and persisting deficit …

Lessons From A Retiring Legal Writing Professor, Mary Ann Robinson

Faculty Publications

No abstract provided.

Design Guidance For Wetland-Road Crossings To Reduce Blanding’S Turtle Mortality Risk, Thomas P. Ballestero, Lauren E. White, Sandra Houghton, David Burdick, Josh Megyesy

Faculty Publications

Road mortality is a leading threat to freshwater turtles, particularly the Blanding’s turtle (Emydoidea blandingii), an endangered species in New Hampshire. Wildlife wetland-crossing structures, such as culverts and/or fences, have proven effective in reducing wildlife road mortality while retaining habitat connectivity. Funding for adequate wetland-crossing creation or restoration is limited, so prioritizing areas of high mortality risk is essential to ensuring that the resources spent are impactful. A research team of professionals from the New Hampshire Department of Environmental Services, New Hampshire Fish and Game, University of New Hampshire, and other organizations formed to create a model capable …

Second Amendment Exceptionalism: Public Expression And Public Carry, Timothy Zick

Faculty Publications

In New York State Rifle & Pistol Ass’n v. Bruen, the Supreme Court recognized a right to carry firearms in public places. The scope of that right will depend on where, why, and how governments regulated public carry during the eighteenth and perhaps nineteenth centuries. The Court claimed that its turn to history for determining the scope of Second Amendment rights “accords with” and “comports with” how the Court has interpreted First Amendment rights. This Article examines and rejects that claim, both in general and specifically as it applies to the public exercise of Second Amendment rights. Although Bruen …

Relations Among Bitcoin Futures, Bitcoin Spot, Investor Attention, And Sentiment, Arun Narayanasamy, Humnath Panta, Rohit Agarwal

Faculty Publications

This research investigates the function of price discovery between the Bitcoin futures and the spot markets while also analyzing the impact of investor sentiment and attention on these markets. This study utilizes various statistical models to examine the short-term and long-term relations between these variables, including the bivariate Granger causality model, the ARDL and NARDL models, and the Johansen cointegration procedure with a vector error correction mechanism. The results suggest that there is no statistical evidence of price discovery between the Bitcoin spot price and futures, and the term structure of the Bitcoin futures neither enriches nor impairs this lead …

Did Artist Meet Architect? Grant Wood & Frank Lloyd Wright In Iowa City, Roy R. Behrens

Faculty Publications

No abstract provided.

The Chatgpt Artificial Intelligence Chatbot: How Well Does It Answer Accounting Assessment Questions?, David A. Wood, Ryan D. Sommerfeldt, Muskan P. Achhpilia, Mollie T. Adams, Sanaz Aghazadeh, William G. Heninger, Jeffrey Pickerd, Jon Kerr

Faculty Publications

ChatGPT, a language-learning model chatbot, has garnered considerable attention for its ability to respond to users’ questions. Using data from 14 countries and 186 institutions, we compare ChatGPT and student performance for 28,085 questions from accounting assessments and textbook test banks. As of January 2023, ChatGPT provides correct answers for 56.5 percent of questions and partially correct answers for an additional 9.4 percent of questions. When considering point values for questions, students significantly outperform ChatGPT with a 76.7 percent average on assessments compared to 47.5 percent for ChatGPT if no partial credit is awarded and 56.5 percent if partial credit …

Entorhinal Cortical Delta Oscillations Drive Memory Consolidation, Juhee Haam, Suman Gunin, Leslie Wilson, Sydney Fry, Briana Bernstein, Eric Thomson, Hayden Noblet, Jesse Cushman, Jerrel L. Yakel

Faculty Publications

Long-term memories are formed by creating stable memory representations via memory consolidation, which mainly occurs during sleep following the encoding of labile memories in the hippocampus during waking. The entorhinal cortex (EC) has intricate connections with the hippocampus, but its role in memory consolidation is largely unknown. Using cell-type- and input-specific in vivo neural activity recordings, here we show that the temporoammonic pathway neurons in the EC, which directly innervate the output area of the hippocampus, exhibit potent oscillatory activities during anesthesia and sleep. Using in vivo individual and populational neuronal activity recordings, we demonstrate that a subpopulation of the …

Leveraging Technology To Promote Access To Justice, Amy Emerson

Faculty Publications

No abstract provided.

Virtual Criminal Law Dualism, Itay Ravid, Hadar Dancig-Rosenberg

Faculty Publications

Since the start of the new millennium, technological and societal changes have initiated a transition from physical to virtual spaces. This farreaching phenomenon has extended to the law and legal institutions, including the criminal law domain. This essay coins the term “virtual criminal law dualism” to describe the dynamic relationship between the virtual and physical spaces in the criminal law sphere. We contend that the transition to virtual spaces has manifested in two distinct aspects. The first relates to formal doctrinal, procedural, and institutional changes that the mainstream criminal law and procedure have undergone due to the emergence of virtual …

Μconadapter: Reinforcement Learning-Based Fast Concurrency Adaptation For Microservices In Cloud, Jianshu Liu, Shungeng Zhang, Qingyang Wang

Faculty Publications

Modern web-facing applications such as e-commerce comprise tens or hundreds of distributed and loosely coupled microservices that promise to facilitate high scalability. While hardware resource scaling approaches [28] have been proposed to address response time fluctuations in critical microservices, little attention has been given to the scaling of soft resources (e.g., threads or database connections), which control hardware resource concurrency. This paper demonstrates that optimal soft resource allocation for critical microservices significantly impacts overall system performance, particularly response time. This suggests the need for fast and intelligent runtime reallocation of soft resources as part of microservices scaling management. We introduce …

140 Characters To Justice? The Promise And Perils Of Using Social Media To Reveal Lay Punishment Perspectives, Itay Ravid, Rotem Dror

Faculty Publications

For centuries, penal theorists have debated two key criminal justice questions: justifying state punishment power and determining proper punishment levels. Moral philosophers offered several theories to address these questions. Over time, calls emerged to move beyond theories and to consider community views on punishment rationales in criminal law and policy design, an approach that gained support alongside meaningful critique. Concurrently, social science advancements enabled empirically deepening understanding of public attitudes about punishment, largely through surveys and experiments.

One domain, however, remained untouched by those calling to assess lay intuitions of justice: social media. Such oversight is puzzling in light of …

Directing The Stereoselectivity Of The Claisen Rearrangement To Form Cyclic Ketones With Full Substitution At The Α-Positions, Fatimat O. Badmus, Raju S. Thombal, Satish Chandra Philkhana, Joshua A. Malone, Christian E. Bailey, Estefania Armendariz-Gonzalez, Edward W. Mureka, Cale M. Locicero, Frank R. Fronczek, Rendy Kartika

Faculty Publications

We report an enantioselective synthesis of cyclic ketones with full substitutions at the α-positions in a highly diastereoselective manner. Our method is achieved by subjecting substrate motifs in 2-allyloxyenones to chiral organomagnesium reagents, which trigger the Claisen rearrangement upon direct 1,2-carbonyl addition. The observed diastereoselectivity of the allyl migration is proposed to originate from the intramolecular chelation of the magnesium alkoxide to the allyloxy moiety.

Augmenting External Surface Pressures’ Predictions On Isolated Low-Rise Buildings Using Cfd Simulations, Md Faiaz Khaled, Aly Mousaad Aly

Faculty Publications

The aim of this paper is to enhance the accuracy of predicting time-averaged external surface pressures on low-rise buildings by utilizing Computational Fluid Dynamics (CFD) simulations. To achieve this, benchmark studies of the Silsoe cube and the Texas Tech University (TTU) experimental building are employed for comparison with simulation results. The paper is structured into three main sections. In the initial part, an appropriate domain size is selected based on the precision of mean pressure coefficients on the windward face of the cube, utilizing Reynolds Averaged Navier-Stokes (RANS) turbulence models. Subsequently, recommendations regarding the optimal computational domain size for an …

Establishment Of A Birth-To-Education Cohort Of 1 Million Palestinian Refugees Using Electronic Medical Records And Electronic Education Records, Zeina Jamaluddine, Akihiro Seita, Ghada Ballout, Hussam Al-Fudoli, Gloria Paolucci, Shatha Albaik, Rami Ibrahim, Miho Sato, Hala Ghattas Ph.D., Oona M.R. Campbell

Faculty Publications

Introduction

By linking datasets, electronic records can be used to build large birth-cohorts, enabling researchers to cost-effectively answer questions relevant to populations over the life-course. Currently, around 5.8 million Palestinian refugees live in five settings: Jordan, Lebanon, Syria, West Bank, and Gaza Strip. The United Nations Relief and Works Agency for Palestine Refugees in the Near East (UNRWA) provides them with free primary health and elementary-school services. It maintains electronic records to do so.

We aimed to establish a birth cohort of Palestinian refugees born between 1st January 2010 and 31st December 2020 living in five settings by linking mother …

Active-Illumination Extension To The Priest And Meier Pbrdf, Mark F. Spencer, Milo W. Hyde Iv, Santasri R. Bose-Pillai, Michael A. Marciniak

Faculty Publications

This paper develops a 3D vector solution for the scattering of partially coherent laser-beam illumination from statistically rough surfaces. Such a solution enables a rigorous comparison to the well-known Priest and Meier polarimetric bidirectional reflectance distribution function (pBRDF) [Opt Eng 41(5),988 (2002).]. Overall, the comparison shows excellent agreement for the normalized spectral density and the degree of polarization. Based on this agreement, the 3D vector solution also enables an extension to the Priest and Meier pBRDF that accounts for the effects of active illumination. In particular, the 3D vector solution enables the development of a closed-form expression for the spectral …

Reply To: Beyond Microbial Carbon Use Efficiency, Feng Tao, Johannes Lehmann, Ying-Ping Wang, Lifen Jiang, Bernhard Ahrens, Kostiantyn Viatkin, Stefano Manzoni, Benjamin Z. Houlton, Yuanyuan Huang, Bruce A. Hungate, Serita D. Frey, Michael W. I. Schmidt, Markus Reichstein, Nuno Carvalhais, Philippe Ciais, Umakant Mishra, Gustaf Hugelius, Toby D. Hocking, Xingjie Lu, Zheng Shi, Ronald Vargas, Yusuf Yigini, Christian Omuto, Ashish A. Malik, Guillermo Peralta, Rosa Cuevas-Corona, Luciano E. Di Paolo, Isabel Luotto, Cuijuan Liao, Yi-Shuang Liang, Vinisa S. Saynes, Xiaomeng Huang

Faculty Publications

In their commentary, Xiao et al. cautioned that the conclusions on the critical role of microbial carbon use efficiency (CUE) in global soil organic carbon (SOC) storage in a paper by Tao et al. (2023) might be too simplistic. They claimed that Tao et al.’s study lacked mechanistic consideration of SOC formation and excluded important datasets. Xiao et al. brought up important points, which can be largely reconciled with our findings by understanding the differences in expressing processes in empirical studies and in models.

Creating An Inclusive Metadata Policy, Nicole Lewis, Jeremy Myntti

Faculty Publications

The BYU Library is creating an Inclusive Metadata Policy for metadata creators to use when creating and remediating descriptions to be more inclusive. Accompanying the policy is a companion document with recommendations and examples, including links to many external resources. In addition to working with stakeholders in the library to develop the policy, we consulted with the University’s Office of Belonging. This presentation describes the process we used to undertake the creation of the library policy and recommendations document.

Law And Its Limits: Ethical Issues In Mary Shelly's Frankenstein Or, The Modern Prometheus, David S. Caudill

Faculty Publications

The law and literature movement is frequently associated with the use of literary images of law as a point of reflection upon the ethical obligations of lawyers. Mary Shelley’s Frankenstein (1818)—the story of a young scientist whose unorthodox experiments end up creating the famed “monster”—is not, at first glance, a likely candidate for that enterprise. However, Dr. Frankenstein’s ambition and ruthless pursuit of knowledge has become a contemporary image of science out of control and the need for ethical limitations on scientific progress. Consequently, the novel raises currently important issues of regulating science and technology. Given the lawyer’s ethical obligation …

Telling Stories In Noise: The Impact Of Background Noises On Spoken Language For People With Aphasia, Tyson G. Harmon, Brenna Scadden Nelson, Christopher Dromey, Kirsten Dixon Clawson

Faculty Publications

Purpose: Determine how different background noise conditions affect the spoken language of participants with aphasia during a story retell task.

Method: Participants included 11 adults with mild to moderate aphasia and 11 age- and gender-matched controls. Participants retold stories in a silent baseline and five background noise conditions (conversation, monologue, phone call, cocktail, pink noise). Dependent measures of speech acoustics (fundamental frequency, mean intensity), speech fluency (speech rate, disfluent words), and language production (correct information units, lexical errors, lexical diversity, and cohesive utterances) were compared between groups and across conditions.

Results: Background noise resulted in higher fundamental frequency (F_{0 …}

Could Our Universe Have Been Initiated Intentionally: An Epistemological Framework, Dan Broadbent

Faculty Publications

The possibility that our universe was initiated intentionally is a compelling philosophical and scientific question that can be evaluated probabilistically based on four primary considerations: fine-tuning in our universe, hypotheses about the multiverse, the likelihood that intelligent life may be able to initiate a universe, and the possibility that we live in a simulation. This paper offers an equation analogous to the noteworthy Drake equation that is intended to be used as a structured thought experiment to help identify factors related to the initiation of our universe and to facilitate examining each in terms of what we know, do not …

Utilizing Student Workers For Digital Commons Projects, Ellen Amatangelo, Elizabeth Parret

Faculty Publications

This lightning talk was presented by the Scholarly Communications Coordinator and the Scholarly Communications Student Supervisor from Brigham Young University at the Digital Commons North American Conference 2023. It provides an overview of how student workers at the BYU Library are involved in Digital Commons projects and discusses the types of projects and processes that students work on, including an outline of student supervisor responsibilities. The purpose of the presentation is to get other Digital Commons administrators excited about expanding the possibilities of their repositories by collaborating with student workers.

Ready Worker One? High-Res Vr For The Home Office, Anastasia Ruvimova, Felipe Fronchetti, Boden A. Kahn, Luiz Henrique Susin, Zekeya Hurley, Thomas Fritz, Mark Hancock, David Shepherd

Faculty Publications

Many employees prefer to work from home, yet struggle to squeeze their office into an already fully-utilized space. Virtual Reality (VR) seemingly offered a solution with its ability to transform even modest physical spaces into spacious, productive virtual offices, but hardware challenges - such as low resolution - have prevented this from becoming a reality. Now that hardware issues are being overcome, we are able to investigate the suitability of VR for daily work. To do so, we (1) studied the physical space that users typically dedicate to home offices and (2) conducted an exploratory study of users working in …

Building A Culture Of Scholarship With New Clinical Teachers By Writing About Social Justice Lawyering, Caroline Wick, Susan Bennett, Binny Miller, Michelle Assad, Maria Dooner, Mariam Hinds, Jessica Millward, Citalli Ochoa, Charles Ross, Anne Schaufele

Faculty Publications

This Article is a collection of essays about teaching social justice lawyering, as seen through the eyes of eight practitioners-in-residence in the clinical program at American University’s Washington College of Law (“WCL”). They include: Michelle Assad, Maria Dooner, Mariam Hinds, Jessica Millward, Citlalli Ochoa, Charles Ross, Anne Schaufele, and Caroline Wick. They teach in seven clinics, including the Civil Advocacy Clinic, the Criminal Justice Clinic, the Community Economic and Equity Development Clinic, the Disability Rights Law Clinic, the Immigrant Justice Clinic, the International Human Rights Law Clinic, and the Janet R. Spragens Federal Income Tax Clinic. We use the terms …

Noise In The Ligo Livingston Gravitational Wave Observatory Due To Trains, J. Glanzer, S. Soni, J. Spoon, A. Effler, G. González

Faculty Publications

Environmental seismic disturbances limit the sensitivity of LIGO gravitational wave detectors. Trains near the LIGO Livingston detector produce low frequency (0.5- 10 H z ) ground noise that couples into the gravitational wave sensitive frequency band (10- 100 H z ) through light reflected in mirrors and other surfaces. We investigate the effect of trains during the Advanced LIGO third observing run, and propose a method to search for narrow band seismic frequencies responsible for contributing to increases in scattered light. Through the use of the linear regression tool Lasso (least absolute shrinkage and selection operator) and glitch correlations, we …

Martin Luther On Praying The Psalms, Mary Jane Haemig

Faculty Publications

No abstract provided.