Digital Commons Network^™

Perspective: The Importance Of Water Security For Ensuring Food Security, Good Nutrition, And Well-Being, Sera L. Young, Edward A. Frongillo Jr., Zeina Jamaluddine, Hugo Melgar-Quiñonez, Rafael Pérez-Escamilla, Claudia Ringler, Asher Y. Rosinger

Faculty Publications

Water security is a powerful concept that is still in its early days in the field of nutrition. Given the prevalence and severity of water issues and the many interconnections between water and nutrition, we argue that water security deserves attention commensurate with its importance to human nutrition and health. To this end, we first give a brief introduction to water insecurity and discuss its conceptualization in terms of availability, access, use, and stability. We then lay out the empirical grounding for its assessment. Parallels to the food-security literature are drawn throughout, both because the concepts are analogous and food …

Comparing Dietary Score Associations With Lipoprotein Particle Subclass Profiles: A Cross-Sectional Analysis Of A Middle-To Older-Aged Population, Seán R. Millar, Pilar Navarro, Janas M. Harrington, Nitin Shivappa Mbbs, Mph, Ph.D., James Hébert Scd, Ivan J. Perry, Catherine M. Phillips

Faculty Publications

Background and objectives: Lipoprotein particle concentrations and size are associated with increased risk for atherosclerosis and premature cardiovascular disease. Studies also suggest that certain dietary behaviours may be cardioprotective. Limited comparative data regarding any dietary score/index-lipoprotein particle subclass associations exist. Thus, our objective was to assess relationships between the Dietary Approaches to Stop Hypertension (DASH), Health Eating Index-2015 (HEI-2015), Mediterranean Diet (MD) and Energy-adjusted Dietary Inflammatory Index (E-DII™) scores and plasma lipids and lipoprotein profiles to test the hypothesis that healthier diet (better quality and more anti-inflammatory) would be associated with a more favourable lipoprotein profile.

Materials and methods: This …

An Evidence-Based Review Of The Pathophysiology, Treatment, And Prevention Of Exercise-Associated Muscle Cramps, Kevin C. Miller, Brendon P. Mcdermott, Susan W. Yeargin, Aidan Fiol, Martin P. Schwellnus

Faculty Publications

Exercise-associated muscle cramps (EAMCs) are common and frustrating for athletes and the physically active. We critically appraised the EAMC literature to provide evidence based treatment and prevention recommendations. Although the pathophysiology of EAMCs appears controversial, recent evidence suggests that EAMCs are due to a confluence of unique intrinsic and extrinsic factors rather than a singular cause. The treatment of acute EAMCs continues to include self-applied or clinician-guided gentle static stretching until symptoms abate. Once the painful EAMCs are alleviated, the clinician can continue treatment on the sidelines by focusing on patient-specific risk factors that may have contributed to the onset …

The Young Age And Plant-Based Diet Hypothesis For Low Sars-Cov-2 Infection And Covid-19 Pandemic In Sub-Saharan Africa, J N. Losso, M N. Losso, M Toc, J N. Inungu, J N. Losso

Faculty Publications

Since the outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that caused the coronavirus disease-19 (COVID-19), in December 2019, the infection has spread around the globe. Some of the risk factors include social distancing, mask wearing, hand washing with soap, obesity, diabetes, hypertension, asthma, cardiovascular disease, and dysbiosis. Evidence has shown the incidence of total infection and death rates to be lower in sub-Saharan Africa when compared with North Africa, Europe and North America and many other parts of the world. The higher the metabolic syndrome rate, the higher the risk of SARS-CoV-2 infection. Africa has a lower …

The Mexico Simsmoke Tobacco Control Policy Model: Development Of A Simulation Model Of Daily And Nondaily Cigarette Smoking, Luz Maria Sanchez-Romero, Luis Zavala-Arciniega, Luz Myriam Reynales-Shigematsu, Belén Sáenz De Miera-Juárez, Zhe Yuan, Yameng Li, Yan Kwan Lau, Nancy L. Fleischer, Rafael Meza, Jim F. Thrasher Ph.D., Ma, Ms, David T. Levy

Faculty Publications

Background

Nondaily smoking has been on the rise, especially in Mexico. While Mexico has strengthened its tobacco control policies, their effects on nondaily smokers have gone largely unexamined. We developed a simulation model to estimate the impact of tobacco control policies on daily and nondaily smoking in Mexico.

Methods

A previously validated Mexico SimSmoke model that estimated overall trends in smoking prevalence from 2002 through 2013 was extended to 2018 and adapted to distinguish daily and nondaily smoking prevalence. The model was then validated using data from Mexican surveys through 2016. To gauge the potential effects of policies, we compared …

Food Insecurity And Frailty Among Women With And Without Hiv In The United States: A Cross-Sectional Analysis, Judy Y. Tan, Lila A. Sheira, Edward A. Frongillo Jr., Deborah Gustafson, Anjali Sharma, Daniel Merenstein, Mardge H. Cohen, Elizabeth Golub, Andrew Edmonds, Igho Ofotokun, Margaret Fischl, Deborah Konkle-Parker, Torsten Neilands, Phyllis Tien, Sheri D. Weiser

Faculty Publications

Introduction: Frailty is frequently observed among people with HIV, and food insecurity is associated with frailty in the general population. Evidence is scarce on the associations between food insecurity and frailty among women with HIV who maybe particularly vulnerable to the impacts of food insecurity. The goal of this study was to assess associations between food insecurity and frailty among women with and without HIV.

Methods: There were 1265 participants from the Women’s Interagency HIV Study who participated in frailty assessments in2017. Frailty was measured using the Fried Frailty Phenotype, and women were subsequently categorized as robust, pre-frailor frail. …

Using Brain-Breaks(R) As A Technology Tool To Increase Attitude Towards Physical Activity Among Students In Singapore, Govidasamy Balasekaran, Ahmad Arif Bin Ibrahim, Ng Yew Cheo, Phua Kia Wang, Garry Kuan, Biljana Popeska, Ming-Kai Chin, Magdalena Mo Ching Mok, Christopher R. Edginton, Ian Culpan, J. Larry Durstine Phd, Facsm, Faacvpr, Fnak

Faculty Publications

The purpose of this study was to investigate the effects of classroom-based Brain Breaks® Physical Activity Solution in Southeast Asia Singaporean primary school students and their attitude towards physical activity (PA) over a ten-week intervention. A total of 113 participants (8–11 years old) were randomly assigned to either an experimental (EG) or a control group (CG), with six classes to each group; the Brain Breaks® group (EG: six classes) and the Control group (CG: six classes). All EG members participated in a Brain Breaks® video intervention (three–five min) during academic classes and the CG continued their lessons as per normal. …

Household Food Insecurity And Children’S Physical Activity And Sedentary Behaviour In The United States: The Healthy Communities Study, Sophia M. Navarro, Marisa M. Tsai, Lorrene D. Ritchie, Edward A. Frongillo Jr., Barbara A. Laraia, Russell R. Pate, Lauren E. Au

Faculty Publications

OBJECTIVE: To examine associations between household food insecurity and children's physical activity and sedentary behaviours. DESIGN: Secondary analysis was conducted on the Healthy Communities Study, an observational study from 2013 to 2015. Household food insecurity was assessed by two items from the US Department of Agriculture's 18-item US Household Food Security Survey Module. Physical activity was measured using the 7-d Physical Activity Behavior Recall instrument. Data were analyzed using multilevel statistical modelling. SETTING: A total of 130 communities in the USA. PARTICIPANTS: In sum, 5138 US children aged 4-15 years. RESULTS: No associations were found for the relationship between household …

Increased Risk Of Death Triggered By Domestic Violence, Hunger, Suicide, Exhausted Health System During Covid-19 Pandemic: Why, How And Solutions, Kenneth Bitrus David, Abdullahi Tunde Aborode, Damilola Quazeem Olaoye, Ndikpongkeabasi Victor Enang, Aboaba Kazeem Oriyomi, Ismaeel Yunusa

Faculty Publications

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, just like many other public health emergencies, is a well-established global health burden that has resulted in several changes in routines and lifestyles of people globally. The coronavirus disease (COVID-19) pandemic, caused by SARS-CoV-2, has directly or indirectly involved in the loss of lives of more than 3.24 million as of 6th May, 2021. The increasing threats posed by this pandemic were subsided by the swift and drastic measures put in place by different countries. As other causes of death before the emergence of COVID-19 still exist, the pandemic has further worsened …

Moderating Effects Of Parental Feeding Practices And Emotional Eating On Dietary Intake Among Overweight African American Adolescents, Mary Quattlebaum, Dawn K. Wilson-King, Allison M. Sweeney, Nicole Zarrett

Faculty Publications

This study examined the effects of parental feeding practices and adolescent emotional eating (EE) on dietary outcomes among overweight African American adolescents. Based on Family Systems Theory, it was hypothesized that parental feeding practices, such as parental monitoring and responsibility, would buffer the effects of EE on poor dietary quality, whereas practices such as concern about a child’s weight, restriction, and pressure-to-eat would exacerbate this relationship. Adolescents (N = 127; Mage = 12.83 ± 1.74; MBMI% = 96.61 ± 4.14) provided baseline data from the Families Improving Together (FIT) for Weight Loss trial and an ancillary study. Dietary outcomes (fruit …

Community Engagement Practices At Research Centers In U.S. Minority Institutions: Priority Populations And Innovative Approaches To Advancing Health Disparities Research, Tabia Henry Akintobi, Payam Sheikhattari, Emma Shaffer, Christina L. Evans, Kathryn L. Braun, Angela U. Sy, Bibiana Mancera, Adriana Campa, Stephania T. Miller, Daniel Sarpong, Rhonda Holliday, Julio Jimenez-Chavez, Shafiq Khan, Cimona Hinton, Kimberly Sellars-Bates, Veronica Ajewole, Nicolette I. Teufel-Shone, Juliet Mcmullin, Sandra Suther, K. Sean Kimbro, Lorraine Taylor

Faculty Publications

This paper details U.S. Research Centers in Minority Institutions (RCMI) Community Engagement Cores (CECs): (1) unique and cross-cutting components, focus areas, specific aims, and target populations; and (2) approaches utilized to build or sustain trust towards community participation in research. A mixed-method data collection approach was employed for this cross-sectional study of current or previously funded RCMIs. A total of 18 of the 25 institutions spanning 13 U.S. states and territories participated. CEC specific aims were to support community engaged research (94%); to translate and disseminate research findings (88%); to develop partnerships (82%); and to build capacity around community research …

Soil Phosphorus Fractions And Distributions In Estuarine Wetlands With Different Climax Vegetation Covers In The Yellow River Delta, Fanzhu Qu, Ling Meng, Jiangbao Xia, Haosheng Huang, Chao Zhan, Yunzhao Li

Faculty Publications

No abstract provided.

Brown Meets Green: Light And Nutrients Alter Detritivore Assimilation Of Microbial Nutrients From Leaf Litter, Taylor L. Price, Jennifer Harper, Steven N. Francoeur, Halvor M. Halvorson, Kevin A. Kuehn

Faculty Publications

In aquatic detrital-based food webs, research suggests that autotroph-heterotroph microbial interactions exert bottom-up controls on energy and nutrient transfer. To address this emerging topic, we investigated microbial responses to nutrient and light treatments during Liriodendron tulipifera litter decomposition and fed litter to the caddisfly larvae Pycnopsyche sp. We measured litter-associated algal, fungal, and bacterial biomass and production. Microbes were also labeled with ¹⁴C and ³³P to trace distinct microbial carbon (C) and phosphorus (P) supporting Pycnopsyche assimilation and incorporation (growth). Litter-associated algal and fungal production rates additively increased with higher nutrient and light availability. Incorporation of microbial P …

Effect Of Informed Conditions On Sensory Expectations And Actual Perceptions: A Case Of Chocolate Brownies Containing Edible-Cricket Protein, Cristhiam Gurdian, Damir Torrico, Bin Li, Georgianna Tuuri, Witoon Prinyawiwatkul

Faculty Publications

No abstract provided.

Advancing Knowledge About Stakeholder Engagement In Multisectoral Nutrition Research, Andrea M. Warren, Shilpa V. Constantinides, Christine E. Blake, Edward A. Frongillo Jr.

Faculty Publications

Strategies to engage stakeholders increase the relevance of multisectoral nutrition research but are challenging to embed within research programs. Drawing from fifteen food choice studies, the aim of this study was to understand the diversity of strategies that researchers used in engaging with stakeholders to synthesize lessons learned from their experiences. Researchers developed and implemented a wide range of strategies that varied in terms of extent of collaboration sought. Informational strategies were used to increase stakeholder buy-in and generate demand for results. Collaborative strategies were more integral to the production of knowledge and were used in framing research significance, interpreting …

Using A Global Food Environment Framework To Understand Relationships With Food Choice In Diverse Low- And Middle-Income Countries, Shilpa V. Constantinides, Christopher Turner, Edward A. Frongillo Jr., Shiva Bhandari, Ligia I. Reyes, Christine E. Blake

Faculty Publications

This study aimed to determine if the Turner et al. (2018) framework allows researchers to identify and study relationships between food environments and individual food choice in diverse contexts and if updates to the framework are warranted. We mapped evidence from 15 drivers of food choice projects to the framework, using thematic analysis to identify common drivers within the food environment across countries and emergent characteristics not listed in the framework. The framework contained breadth and depth of content necessary to identify common drivers – prices and affordability, availability, and vendor and product properties. Insights regarding common drivers and emergent …

Association Of Cumulative Social Risk And Social Support With Receipt Of Chemotherapy Among Patients With Advanced Colorectal Cancer, Rachel E. Davis, Amber W. Trickey, Paul Abrahamse, Ikuko Kato, Kevin Ward, Arden M. Morris

Faculty Publications

Importance: Approximately 38% of patients with advanced colorectal cancer do not receive chemotherapy. Objective: To determine whether cumulative social risk (ie, multiple co-occurring sociodemographic risk factors) is associated with lower receipt of chemotherapy among patients with advanced colorectal cancer and whether social support would moderate this association. Design, Setting, and Participants: This cross-sectional, population-based, mailed survey study was conducted from 2012 to 2014. Participants were recruited between 2011 and 2014 from all adults within 1 year after diagnosis of stage III colorectal cancer in the Detroit, Michigan, and State of Georgia Surveillance, Epidemiology, End-Results cancer registries. Patients were eligible if …

Nutrition Interventions In Low-Income Rural And Urban Retail Environments: A Systematic Review, Linda Fergus, Katherine Seals, Denise Holston

Faculty Publications

Background: Nutrition interventions promoting healthy food choices aim to address health challenges of residents in low-income environments. Research about the effectiveness of nutrition interventions in low-income populations is limited, particularly for those in rural areas. Behavioral economics (BE) strategies demonstrate effectiveness for improving eating behaviors in some settings. However, the efficacy of BE interventions in retail food stores serving low-income populations residing in rural and urban geographies is nascent. Objective: This systematic literature review aims to identify and compare nutrition interventions implemented in rural and urban low-income retail food stores, including BE strategies when applied. Methods: This review was conducted …

The Status Of Spotted Seatrout (Cynoscion Nebulosus) As A Technologically Feasible Species For U.S. Marine Aquaculture, Reginald Blaylock, Eric Saillant, Angelos Apeitos, David Abrego, Paul Cason, Robert Vega

Faculty Publications

Culture models and facilities for large-scale, commercial production of popular Gulf of Mexico species are unavailable. The spotted seatrout (Cynoscion nebulosus) is one of the most popular recreational fishes in the Gulf of Mexico. Seatrout culture techniques were adapted from red drum (Sciaenops ocellatus) protocols developed in the 1970s. Broodstock husbandry, spawning, and extensive pond rearing techniques using fertilized and bloomed brackish ponds were well-established by the 1980s. By 2018, approximately 80 million 25–30-day old seatrout had been produced, mainly for stock enhancement. Cannibalism and poor nutrition hindered intensive tank culture. Between 2005 and 2015, an …

First Data On Aquaculture Of The Tripletail, Lobotes Surinamensis, A Promising Candidate Species For U.S. Marine Aquaculture, Eric Saillant, Nicholas Adams, Jason T. Lemus, James S. Franks, Yonathan Zohar, John Stubblefield, Christopher Manley

Faculty Publications

The Tripletail, Lobotes surinamensis, is a warm-water pelagic fish that is increasingly targeted by U.S. anglers. The superior quality of Tripletail flesh coupled with the lack of domestic commercial fisheries stimulated interests to develop aquaculture of this species. In this work, photo-thermal conditioning of captive-held broodstocks promoted maturation in females, but spontaneous spawning was not observed. GnRHa slow-release implants induced ovulation in late vitellogenic females but fertility remained below 10% when GnRHa was administered alone. However, spawns with high fertility (up to 85%) were obtained when a dopamine antagonist was administered in conjunction with GnRHa implants indicating dopamine inhibition …

Correction To: Factor Structure And Equivalence Of Maternal Resources For Care In Bangladesh, Vietnam, And Ethiopia, Sulochana Basnet, Edward A. Frongillo Jr., Phuong Hong Nguyen, Spencer Moore, Mandana Arabi

Faculty Publications

No abstract provided.

Safeguarding The Lives Of Children Affected By Boko Haram: Application Of The Safe Model Of Child Protection To A Rights-Based Situation Analysis, Rosie O'Connor, Theresa S. Betancourt, Ngozi V. Enelamah

Faculty Publications

The Boko Haram insurgency in northeast Nigeria is responsible for the highest number of lives lost in Africa in the past decade. The country has witnessed significant violations of the United Nations Convention on the Rights of the Child, which Nigeria has signed and ratified. For instance, Nigeria had the second-highest number of children recruited to armed groups and the third-highest number of abductions in 2018. Current humanitarian efforts primarily target camps for internally displaced persons, while state strategies focus mainly on addressing security through combatant-targeted interventions. However, there is a need for more rights-based, integrated, and multifaceted approaches to …

Effects Of Timber Harvest On Epigeous Fungal Fruiting Patterns And Community Structure In A Northern Hardwood Ecosystem, Benjamin W. Borgmann-Winter, Ryan B. Stephens, Anthony W. D'Amato, Serita D. Frey, Rebecca J. Rowe

Faculty Publications

Epigeous fungal fruiting has important impacts on fungal reproduction and ecosystem function. Forest disturbances, such as timber harvest, impact moisture, host availability, and substrate availability, which in turn may drive changes in fungal fruiting patterns and community structure. We surveyed mushrooms in 0.4 ha patch cuts (18 months post-harvest) and adjacent intact hardwood forest in northern New Hampshire, USA, to document the effects of timber harvest on summer fruiting richness, biomass, diversity, and community structure of ectomycorrhizal, parasitic, and saprobic mushroom taxa. Fungal fruiting richness, diversity, and community heterogeneity were greater in intact forests than patch cuts. Among functional groups, …

Year-Independent Prediction Of Food Insecurity Using Classical & Neural Network Machine Learning Methods, Caleb Christiansen, Torrey J. Wagner, Brent Langhals

Faculty Publications

Current food crisis predictions are developed by the Famine Early Warning System Network, but they fail to classify the majority of food crisis outbreaks with model metrics of recall (0.23), precision (0.42), and f1 (0.30). In this work, using a World Bank dataset, classical and neural network (NN) machine learning algorithms were developed to predict food crises in 21 countries. The best classical logistic regression algorithm achieved a high level of significance (p < 0.001) and precision (0.75) but was deficient in recall (0.20) and f1 (0.32). Of particular interest, the classical algorithm indicated that the vegetation index and the food price index were both positively correlated with food crises. A novel method for performing an iterative multidimensional hyperparameter search is presented, which resulted in significantly improved performance when applied to this dataset. Four iterations were conducted, which resulted in excellent 0.96 for metrics of precision, recall, and f1. Due to this strong performance, the food crisis year was removed from the dataset to prevent immediate extrapolation when used on future data, and the modeling process was repeated. The best “no year” model metrics remained strong, achieving ≥0.92 for recall, precision, and f1 while meeting a 10% f1 overfitting threshold on the test (0.84) and holdout (0.83) datasets. The year-agnostic neural network model represents a novel approach to classify food crises and outperforms current food crisis prediction efforts.

Examination Of Weight-Loss Motivators And Family Factors In Relation To Weight Management Strategies And Dietary Behaviors Among Adolescents With Obesity, Bridget K. Biggs, Dawn K. Wilson, Mary Quattlebaum, Seema Kumar, Alicia Meek, Teresa B. Jensen

Faculty Publications

The study aim was to test hypotheses informed by self-determination theory (SDT) regarding associations of adolescent motivators for weight loss and family feeding practices on understanding adolescent weight management and dietary behaviors. Adolescents (n = 71) with obesity were recruited from a large medical center in the Midwest USA and completed questionnaire assessments via an online survey. Results supported hypotheses that endorsement of health motivators for weight loss, conceptualized as autonomous (intrinsic) motivation, and positive family support would be associated with healthier weight management practices and dietary behaviors. Nuanced findings related to social- and self-esteem-related motivators for weight loss indicated …

Community Support Model On Breastfeeding And Complementary Feeding Practices In Remote Areas In Vietnam: Implementation, Cost, And Effectiveness, Tuan T. Nguyen, Nemat Hajeebhoy, Jia Li, Chung T. Do, Roger Mathisen, Edward A. Frongillo Jr.

Faculty Publications

Background

Poor access to healthcare facilities and consequently nutrition counseling services hinders the uptake of recommended infant and young child feeding (IYCF) practices. To address these barriers and improve IYCF practices, Alive & Thrive (A&T) initiated community support groups in remote villages across nine provinces in Vietnam.

Objective

This study examines the effectiveness of the support group model and related project costs for reaching underserved areas to improve IYCF practices.

Methods

To evaluate the model’s implementation and project costs, we reviewed implementation guidelines, expenditure and coverage reports, monitoring data, and budgets for the nine provinces. To evaluate the model’s effectiveness, …

Differences In ​The Proportion Of Children Meeting Behavior Guidelines ​Between Summer ​And School By Socioeconomic Status And Race, Ethan T. Hunt, Lauren Von Klinggraeff, Alexis Jones, Sarah Burkart, Roddrick Dugger, Bridget Armstrong Ph.D., Michael Beets Ph.D., Gabrielle Turner-Mcgrievy Ph.D., Rd, Marco Geraci, Robert Glenn Weaver Med, Phd

Faculty Publications

Objective

Children who fail to meet activity, sleep, and screen-time guidelines are at increased risk for obesity. Further, children who are Black are more likely to have obesity when compared to children who are White, and children from low-income households are at increased risk for obesity when compared to children from higher-income households. The objective of this study was to evaluate the proportion of days meeting obesogenic behavior guidelines during the school year compared to summer vacation by race and free/reduced priced lunch (FRPL) eligibility.

Methods

Mixed-effects linear and logistic regressions estimated the proportion of days participants met activity, sleep, …

De Novo Transcriptome Assembly Of The Green Alga Ankistrodesmus Falcatus, Rachel A. Schomaker, Jeffry L. Dudycha

Faculty Publications

Ankistrodesmus falcatus is a globally distributed freshwater chlorophyte that is a candidate for biofuel production, is used to study the effects of toxins on aquatic communities, and is used as food in zooplankton research. Each of these research fields is transitioning to genomic tools. We created a reference transcriptome for of A. falcatus using NextGen sequencing and de novo assembly methods including Trinity, Velvet-Oases, and EvidentialGene. The assembled transcriptome has a total of 17,997 contigs, an N50 value of 2,462, and a GC content of 64.8%. BUSCO analysis recovered 83.3% of total chlorophyte BUSCOs and 82.5% of the eukaryotic …

Circadian Rhythms In Legumes: What Do We Know And What Else Should We Explore?, Hazel Marie Kugan, Nur Ardiyana Rejab, Nurul Amylia Sahruzaini, Jennifer Ann Harikrishna, Niranjan Baisakh, Acga Cheng

Faculty Publications

The natural timing devices of organisms, commonly known as biological clocks, are composed of specific complex folding molecules that interact to regulate the circadian rhythms. Circadian rhythms, the changes or processes that follow a 24‐h light–dark cycle, while endogenously programmed, are also influenced by environmental factors, especially in sessile organisms such as plants, which can impact ecosystems and crop productivity. Current knowledge of plant clocks emanates primarily from research on Arabidopsis, which identified the main components of the circadian gene regulation network. Nonetheless, there remain critical knowledge gaps related to the molecular components of circadian rhythms in important crop groups, …

Recent Advances In Understanding Tick And Rickettsiae Interactions, Shahid Karim, Deepak Kumar, Khemraj Budachetri

Faculty Publications

Ticks are haematophagous arthropods with unique molecular mechanisms for digesting host blood meal while acting as vectors for various pathogens of public health significance. The tick's pharmacologically active saliva plays a fundamental role in modulating the host's immune system for several days to weeks, depending on the tick species. The vector tick has also developed sophisticated molecular mechanisms to serve as a competent vector for pathogens, including the spotted fever group (SFG) rickettsiae. Evidence is still inadequate concerning tick–rickettsiae–host interactions and saliva-assisted transmission of the pathogen to the mammalian host. Rickettsia parkeri, of the SFG rickettsia, can cause a …