Digital Commons Network^™

Electronic Media Exposure And Its Association With Activity-Related Outcomes In Female Adolescents: Cross-Sectional And Longitudinal Analyses, Felipe Lobelo, Marsha Dowda, Karin A. Pfeiffer, Russell R. Pate

Faculty Publications

Background: Few investigations have assessed in adolescent girls the cross-sectional and longitudinal associations between elevated exposure to electronic media (EM) and activity-related outcomes such as compliance with physical activity (PA) standards or cardiorespiratory fitness (CRF). Methods: Four-hundred thirty-seven white and African American girls were assessed at the 8th, 9th, and 12th grades. PA and EM (TV/video watching, electronic games, Internet use) were self-reported, and CRF was estimated using a cycle-ergometer test. Hi EM exposure was defined as ≥ four 30-minute blocks/d. Results: 8th-, 9th-, and 12th-grade girls in the Hi EM group showed lower compliance with PA standards and had …

Age-Related Change In Physical Activity In Adolescent Girls, Russell R. Pate, June Stevens, Larry S. Webber, Marsha Dowda, David M. Murray, Deborah R. Young, Scott Going

Faculty Publications

Purpose - To determine the annual rate at which physical activity changes in girls during middle school using both objective and self-report measures of physical activity.

Methods - Participants were 6^th and 8^th grade girls from the control schools in the Trial of Activity for Adolescent Girls (TAAG). Random cross-sectional samples initially were drawn from 6^th grade girls (n=786) and two years later from 8^th grade girls (n=1545). A cohort of 501 girls was in both the 6^th and 8^th grade samples. The girls wore an accelerometer for six days and completed the 3-Day …

Salivary Gland Thrombostasin Isoforms Differentially Regulate Blood Uptake Of Horn Flies Fed On New Zealand White Rabbits, Mary S. Cupp, Eddie W. Cupp, Dunhua Zhang, Xin Yue, Latora Todd, Victor Panangala, Christine Navarre, Elizabeth Whitley

Faculty Publications

Thrombostasin (TS) is a previously characterized anticlotting protein with multiple isoforms found in the saliva of horn flies. In this report, the effect of TS isoforms on blood feeding was assessed using individual flies that carried corresponding ts allelles. Laboratory studies of horn fly blood feeding were conducted using colony-reared flies fed on New Zealand White (NZW) rabbits. After timed 20-min feeding periods, each fly was characterized for gender, blood volume uptake, and ts genotype. The results showed that mean blood volumes obtained by individual flies were not related to fly gender but were correlated to the ts genotype(s) carried …

Salivary Gland Thrombostasin Isoforms Differentially Regulate Blood Uptake Of Horn Flies Fed On New Zealand White Rabbits, Mary S. Cupp, Eddie W. Cupp, Dunhua Zhang, Xin Yue, Latora Todd, Victor Panangala, Christine Navarre, Elizabeth Whitley

Faculty Publications

Thrombostasin (TS) is a previously characterized anticlotting protein with multiple isoforms found in the saliva of horn flies. In this report, the effect of TS isoforms on blood feeding was assessed using individual flies that carried corresponding ts allelles. Laboratory studies of horn fly blood feeding were conducted using colony-reared flies fed on New Zealand White (NZW) rabbits. After timed 20-min feeding periods, each fly was characterized for gender, blood volume uptake, and ts genotype. The results showed that mean blood volumes obtained by individual flies were not related to fly gender but were correlated to the ts genotype(s) carried …

Reduced Adipose Tissue Oxygenation In Human Obesity Evidence For Rarefaction, Macrophage Chemotaxis, And Inflammation Without An Angiogenic Response, Magdalena Pasarica, Olga R. Sereda, Leanne M. Redman, Diana C. Albarado, David T. Hymel, Laura E. Roan, Jennifer C. Rood, David H. Burk, Steven R. Smith

Faculty Publications

OBJECTIVE-Based on rodent studies, we examined the hypothesis that increased adipose tissue (AT) mass in obesity without an adequate support of vascularization might lead to hypoxia, macrophage infiltration, and inflammation. RESEARCH DESIGN AND METHODS-Oxygen partial pressure (AT pO 2) and AT temperature in abdominal AT (9 lean and 12 overweight/obese men and women) was measured by direct insertion of a polarographic Clark electrode. Body composition was measured by dual-energy X-ray absorptiometry, and insulin sensitivity was measured by hyperinsulinemic-euglycemic clamp. Abdominal subcutaneous tissue was used for staining, quantitative RT-PCR, and chemokine secretion assay. RESULTS-AT pO 2 was lower in overweight/obese subjects …

Self-Reported Physical Activity Improves Prediction Of Body Fatness In Young Adults, M. Zanovec, Lisa G. Johnson, Brian D. Marx, Michael J. Keenan, G. Tuuri

Faculty Publications

PURPOSE: To examine self-reported physical activity levels from the International Physical Activity Questionnaire (IPAQ) as an independent predictor of dual-energy x-ray absorptiometry (DXA)-measured percent body fat (%BF) from body mass index (BMI), gender, and race. METHODS: Two hundred and seventy-eight students, aged 18-24 yr, volunteered to participate. There were 133 males (85 white and 48 black) and 145 females (77 white and 68 black). Total activity levels were quantified in MET hours per week (MET-h•wk -1) using the IPAQ short form. Height and weight were measured, and BMI values were calculated (kg•m -2). %BF was assessed using DXA. Linear regression …

Eating Routines: Embedded, Value Based, Modifiable, And Reflective, Margaret M. Jastran, Carole A. Bisogni, Jeffrey Sobal, Christine E. Blake, Carol M. Devine

Faculty Publications

Eating routines are a compelling issue because recurring eating behaviors influence nutrition and health. As non-traditional and individualized eating patterns have become more common, new ways of thinking about routine eating practices are needed. This study sought to gain conceptual understanding of working adults' eating routines. Forty-two purposively sampled US adults reported food intake and contextual details about eating episodes in qualitative 24-h dietary recalls conducted over 7 consecutive days. Using the constant comparative method, researchers analyzed interview transcripts for recurrent ways of eating that were either explicitly reported by study participants as "routines" or emergent in the data. Participants' …

Changes In Weight, Waist Circumference And Compensatory Responses With Different Doses Of Exercise Among Sedentary, Overweight Postmenopausal Women, Timothy S. Church, Corby K. Martin, Angela M. Thompson, Conrad P. Earnest, Catherine R. Mikus, Steven N. Blair

Faculty Publications

Background: It has been suggested that exercise training results in compensatory mechanisms that attenuate weight loss. However, this has only been examined with large doses of exercise. The goal of this analysis was to examine actual weight loss compared to predicted weight loss (compensation) across different doses of exercise in a controlled trial of sedentary, overweight or obese postmenopausal women (n=41).

Methodology/Principal Findings: Participants were randomized to a non-exercise control (n=94) or 1 of 3 exercise groups; exercise energy expenditure of 4 (n=139), 8 (n=85), or 12 (n=93) kcal/kg/week (KKW). Training intensity was set at the heart rate associated with …

Antenatal Peer Support Workers And Initiation Of Breast Feeding: Cluster Randomised Controlled Trial, Christine Macarthur, Kate Jolly, Lucy Annang Ingram Phd, Nick Freemantle, Cindy-Lee Dennis, Ros Hamburger, Julia Brown, Jackie Chambers, Khalid Khan

Faculty Publications

OBJECTIVE: To assess the effectiveness of an antenatal service using community based breastfeeding peer support workers on initiation of breast feeding. DESIGN: Cluster randomised controlled trial. SETTING: Community antenatal clinics in one primary care trust in a multiethnic, deprived population. PARTICIPANTS: 66 antenatal clinics with 2511 pregnant women: 33 clinics including 1140 women were randomised to receive the peer support worker service and 33 clinics including 1371 women were randomised to receive standard care. INTERVENTION: An antenatal peer support worker service planned to comprise a minimum of two contacts with women to provide advice, information, and support from approximately 24 …

Does Television Viewing Predict Dietary Intake Five Years Later In High School Students And Young Adults?, Daheia J. Barr-Anderson, Nicole I. Larson, Melissa C. Nelson, Dianne R. Neumark-Sztainer, Mary Story

Faculty Publications

Background: Prior research has found that television viewing is associated with poor diet quality, though little is known about its long-term impact on diet, particularly during adolescence. This study examined the associations between television viewing behavior with dietary intake five years later.

Methods: Survey data, which included television viewing time and food frequency questionnaires, were analyzed for 564 middle school students (younger cohort) and 1366 high school students (older cohort) who had complete data available at Time1 (1998-1999) and five years later at Time 2 (mean age at Time 2, 17.2 ± 0.6 and 20.5 ± 0.8 years, respectively). Regression …

Race And Ancestry In Biomedical Research: Exploring The Challenges, Timothy Caulfield, Stephanie M. Fullerton, Sarah E. Ali-Khan, Laura Arbour, Esteban G. Burchard, Richard S. Cooper, Billie Jo Hardy, Simrat Harry, Robyn Hyde-Lay, Jonathan Kahn, Rick Kittles, Barbara A. Koenig, Sandra S.J. Lee, Michael Malinowski, Vardit Ravitsky, Pamela Sankar, Stephen W. Scherer, Béatrice Séguin, Darren Shickle, Guilherme Suarez-Kurtz, Abdallah S. Daar

Faculty Publications

The use of race in biomedical research has, for decades, been a source of social controversy. However, recent events, such as the adoption of racially targeted pharmaceuticals, have raised the profile of the race issue. In addition, we are entering an era in which genomic research is increasingly focused on the nature and extent of human genetic variation, often examined by population, which leads to heightened potential for misunderstandings or misuse of terms concerning genetic variation and race. Here, we draw together the perspectives of participants in a recent interdisciplinary workshop on ancestry and health in medicine in order to …

Whole-Genome Association Study Identifies Stk39 As A Hypertension Susceptibility Gene, Ying Wang, Jeffrey R. O'Connell, Patrick F. Mcardle, James B. Wade, Sarah E. Dorff, Sanjiv J. Shah, Xiaolian Shi, Lin Pan, Evadnie Rampersaud, Haiqing Shen, James D. Kim, Arohan R. Subramanya, Nanette I. Steinle, Afshin Parsa, Carole C. Ober, Paul A. Welling, Aravinda Chakravarti, Alan B. Weder, Richard S. Cooper, Braxton D. Mitchell, Alan R. Shuldiner, Yen Pei C. Chang

Faculty Publications

Hypertension places a major burden on individual and public health, but the genetic basis of this complex disorder is poorly understood. We conducted a genome-wide association study of systolic and diastolic blood pressure (SBP and DBP) in Amish subjects and found strong association signals with common variants in a serine/threonine kinase gene, STK39. We confirmed this association in an independent Amish and 4 non-Amish Caucasian samples including the Diabetes Genetics Initiative, Framingham Heart Study, GenNet, and Hutterites (meta-analysis combining all studies: n = 7,125, P < 10-6). The higher BP-associated alleles have frequencies > 0.09 and were associated with increases of 3.3/1.3 mm Hg in SBP/DBP, respectively, in the …

Health Effects Of Vegan Diets, Winston J. Craig

Faculty Publications

Recently, vegetarian diets have experienced an increase in popularity. Avegetarian diet is associated with many health benefits because of its higher content of fiber, folic acid, vitamins C and E, potassium, magnesium, and many phytochemicals and a fat content that is more unsaturated. Compared with other vegetarian diets, vegan diets tend to contain less saturated fat and cholesterol and more dietary fiber. Vegans tend to be thinner, have lower serum cholesterol, and lower blood pressure, reducing their risk of heart disease. However, eliminating all animal products from the diet increases the risk of certain nutritional deficiencies. Micronutrients of special concern …

Calls For Accountability: Will It Help The Overall Incentives Process?, Annette M. Nellen

Faculty Publications

No abstract provided.

Effects Of Intermittent Suckling On Sow And Piglet Performance, Erin G. Brown, Lindsey B. Krebs, Chris L. Boone, Ty Cauthen

Faculty Publications

The objective of this study was to evaluate effects of intermittent suckling on sow and litter performance. Seventeen crossbred sows and litters were randomly assigned to treatment groups seven days prior to weaning: continuous suckling (CS) and intermittent suckling (IS; litters removed for 6 hr each from day 21 to 28). Litters were weaned at 28 days of age. Feed and water were available to litters and sows at all times. Feed intake was recorded. Body condition scores were collected on sows before farrowing and at weaning. Number of days to return-to-estrus for the sows was also recorded. Litters were …

Wintering Yellow-Bellied Sapsucker Time Activity Budgets In East Texas Bottomland Hardwood Forests (Abstract), Jason R. Speights, Warren C. Conway

Faculty Publications

We developed time-activity budgets for 286 Yellow-bellied Sapsuckers (Sphyrapicus varius) from October 2005/2006 to March 2006/2007 in east Texas bottomland hardwood forests. Behaviors were similar between genders and study sites (P > 0.05), but varied (P = 0.008) between years. Sapsuckers spent more time foraging upon arrival in wintering areas and during morning throughout the study periods. Deviation from monthly average low temperature was an important (P = 0.038) covariate during the second study year, when sapsuckers increased time spent foraging during colder than average temperatures and increased time perching on days with warmer than average …

Winter Food Habits And Preferences Of Northern Bobwhites In East Texas, Donald R. Dietz, R. Montague Whiting Jr., Nancy E. Koerth

Faculty Publications

During late winter, 1994 and 1995, we investigated food habits and preferences of northern bobwhites (Colinus virginianus; hereafter, bobwhites) collected on forested lands in east Texas. Crops for bobwhites were collected from areas under 3 management regimes, namely intensively managed for bobwhites (QMA) (i.e., tree basal area reduced, annually burned, numerous multi-stage food plots, etc.), extensively managed for timber and wildlife (NBS) (i.e., burned every 3-5 years, scattered 2-stage food plots with corn feeders), and unmanaged for wildlife (i.e., burned every 5-7 years). With years pooled, partridge pea (Cassia fasciculata), Hercules club (Zanthoxylum clava-herculis), and pine (Pinus spp.) seeds, and …

Sunday Friends: The Working Alternative To Charity, James D. Lee, Yoko Baba, Claudio V. Sanchez, Rebecca Wang, Chelsey White

Faculty Publications

Sunday Friends is a non-profit organization in San José, California, that provides multiple activities for families who are in need of financial support. Given the particular location of the program, most families are Latino and bilingual. Participants and program volunteers form a community at an elementary school on a couple of scheduled Sundays each month. When family members participate in activities designed to educate, improve skills, and to give back to the larger community, they earn tickets that they can redeem for items that they need and want from the Sunday Friends store. Activities include healthy cooking projects, “Thank You …

Rules Limiting Athletic Performance Or Prohibiting Athletic Participation For Health Reasons: Legal And Ethical Considerations, Matthew J. Mitten

Faculty Publications

This article analyzes the paradox between: 1) intercollegiate sport's objectives of maximizing athletic performance and providing athletic participation opportunities to those possessing the requisite physical ability and skills to compete successfully; and 2) National Collegiate Athletic Association rules that limit athletic performance by all student-athletes, or university requirements that prohibit individual student-athletes from participating in intercollegiate sports, for health reasons. Some student-athletes seek to maximize athletic performance by taking performance-enhancing substances, even if doing so creates potential future adverse health effects. Others may want to participate in intercollegiate sports with a physical abnormality and are willing to assume an increased …

Making All The Children Above Average: Ethical And Regulatory Concerns For Pediatricians In Pediatric Enhancement Research, Jessica W. Berg, Maxwell J. Mehlman, Daniel B. Rubin, Eric Kodish

Faculty Publications

Building on the knowledge generated by the long history of disease-oriented research, the next few decades will witness an explosion of biomedical enhancements to make people faster, stronger, smarter, less forgetful, happier, prettier, and live longer. Growing interest in pediatric enhancements is likely to stimulate the conduct of enhancement research involving children. However, guidelines for the protection of human subjects were developed for investigations of therapeutic modalities. To date, virtually no attention has been paid to whether these rules would be appropriate for investigations to establish the safety and efficacy of technologies intended for enhancement rather than therapeutic uses and, …

Preparing For Disaster: Protecting The Most Vulnerable In Emergencies, Sharona Hoffman

Faculty Publications

Many federal, state, local and private entities are investing significant resources in disaster readiness initiatives. Often disregarded, however, are the special needs of vulnerable populations during disasters. In the context of emergencies, vulnerable groups may include individuals with disabilities, pregnant women, children, the elderly, prisoners, members of ethnic minorities, people with language barriers, and the impoverished. The fate of the disadvantaged during disasters has received little attention in the legal literature, and this article begins to fill that gap. It examines ethical theories of distributive justice and existing federal and state civil rights and emergency response laws and argues that …

Diverse Elevational Diversity Gradients In Great Smoky Mountains National Park, U.S.A., Nathan J. Sanders, Robert R. Dunn, Matthew C. Fitzpatrick, Christopher E. Carlton, Michael R. Pogue, Charles R. Parker, Theodore R. Simons

Faculty Publications

© 2010 by Taylor and Francis Group, LLC. Less well studied, however, are the factors that shape elevational diversity gradients. Because many climatic factors vary systematically along elevational gradients, as they might along latitudinal gradients, elevational diversity gradients were thought to be miniature versions of latitudinal gradients (Körner, 2000). For example, Brown (1988) wrote, “Just as change of physical conditions with altitude resembles in many respects the variation with latitude, so the decreasing diversity of most organisms with increasing elevation mirrors in most respects the latitudinal gradient of species richness.” Stevens (1992) noted that, “Biologists have long recognized that elevational …

Participation And The Right To Health: Lessons From Indonesia, Sam F. Halabi

Faculty Publications

The right to participation is the “the right of rights” — the basic right of people to have a say in how decisions that affect their lives are made. All legally binding international human rights treaties explicitly recognize the essential role of participation in realizing fundamental human rights. While the substance of the human right to health has been extensively developed, the right to participation as one of its components has remained largely unexplored. Should rights-based health advocacy focus on participation because there is a relationship between an individual’s or a community’s active involvement in health care decision-making and the …

Sos1 And Halophytism., Dong Ha Oh, Ali Zahir, Dae Jin Yun, Ray A. Bressan, Hans J. Bohnert

Faculty Publications

Much is already known about the function and functioning of the three genes that make up the SOS (Salt-Overly-Sensitive) pathway in plants, but recent studies indicate that the linkage between external increases in salinity and stress protection provided by genes SOS1, SOS2 and SOS3 is more complex than previously appreciated. It has recently been shown that the engineered reduced expression of the sodium/proton antiporter SOS1 affected several pathways indicating a role for SOS1 that exceeds its known function as an antiporter. Interference with expression of SOS1, characterized as a sodium/proton antiporter in the halophyte Thellungiella salsuginea converted Thellungiella into an …

Adipose Tissue Collagen Vi In Obesity, Magdalena Pasarica, Barbara Gowronska-Kozak, David Burk, Isabel Remedios, David Hymel, Jeff Gimble, Eric Ravussin, George A. Bray, Steven R. Smith

Faculty Publications

Objectives: Basic science studies show that the extracellular matrix of adipose tissue, mainly represented by collagen VI, is dysfunctional in obesity and contributes to the development of the metabolic syndrome. We hypothesized in humans that increased collagen VI α3-subunit (COL6A3) mRNAis associated with adipose tissue macrophage chemotaxis and inflammation and that weight gain is accompanied by changes in the expression of COL6A3. Research Design and Methods: Adipose tissue biopsies were obtained from a cross-sectional study (n = 109), an overfeeding study (n = 9), and a pioglitazone treatment study (n = 14). Adipose tissue gene expression was measured by quantitative …

Obesity Management In Adults With Ckd, Holly Kramer, Katherine R. Tuttle, David Leehey, Amy Luke, Ramon Durazo-Arvizu, David Shoham, Richard Cooper, Srinvisan Beddhu

Faculty Publications

All adults, including those with and without CKD, should receive counseling on the benefits of a healthy lifestyle, which includes a healthy diet, physical activity, and smoking cessation. In people with CKD who are overweight, but not obese, potential benefits of weight loss to the recommended "ideal" range are uncertain. Nevertheless, obesity is associated with increased inflammation, insulin resistance, hypertension, and dyslipidemia, and overweight adults with CKD should be counseled about the risks of weight gain. In persons with CKD and generalized or abdominal obesity, weight loss should be encouraged. For patients on dialysis therapy, survival can be greatly increased …

Energy Expenditure Does Not Predict Weight Change In Either Nigerian Or African American Women, Amy Luke, Lara R. Dugas, Kara Ebersole, Ramon A. Durazo-Arvizu, Guichan Cao, Dale A. Schoeller, Adebowale Adeyemo, William R. Brieger, Richard S. Cooper

Faculty Publications

Background: The relation between variation in interindividual levels of energy expenditure and weight gain remains controversial. Objective: To determine whether or not components of the energy budget predict weight change, we conducted an international comparative study in 2 cohorts of women from sociocultural environments that give rise to the extremes of obesity prevalence. Design: This was a prospective study with energy expenditure measured at baseline and weight measured annually for 3 y. Participants included 149 women from rural Nigeria and 172 African American women. The energy budget was determined by using respiratory gas exchange and doubly labeled water. Main outcomes …

Reaction Of Potato Cultivars To Streptomyces Scabies, Causal Agent Of Deep Common Scab, Ivan Herman Fischer, Ana Paula Matoso Teixeira, Leonardo Toffano, Ely Oliveira Garcia

Faculty Publications

This work aimed to characterize the isolates of Streptomyces, responsible for deep common scab symptoms in potato, according to morphological and physiological criteria; to evaluate the resistance of potato cultivars to the disease and the aggressiveness of bacterium isolates. The Streptomyces isolates presented gray coloration on yeast extract and malt medium and spiral spore chains, produced on aerial hyphae. Production of melanina occurred in tirosine-agar medium and the utilization of eight recommended carbon sources. These properties correspond to the S. scabies species. Healthy potato seeds of six cultivars were planted in substratum infested with six isolates of S. scabies separately, …

Sperm Cryopreservation Of A Live-Bearing Fish, Xiphophorus Couchianus: Male-To-Male Variation In Post-Thaw Motility And Production Of F1 Hybrid Offspring, Huiping Yang, Leona Hazlewood, Ronald B. Walter, Terrence R. Tiersch

Faculty Publications

Fishes of the genus Xiphophorus are well-studied biomedical research models, and some species, such as X. couchianus, are currently listed as endangered in the wild. Sperm cryopreservation in these live-bearing fishes has begun recently. Thus far, live young have been produced with cryopreserved sperm only in one species (Xiphophorus helleri). In this study, the goal was to develop a practical protocol for sperm cryopreservation of Xiphophorus couchianus, and to produce live young with cryopreserved sperm. Sperm were collected by crushing of testis in Hanks' balanced salt solution at an osmolality of 500 mOsmol/kg (HBSS500), and were cryopreserved with 14% glycerol …

Current Status Of Sperm Cryopreservation In Biomedical Research Fish Models: Zebrafish, Medaka, And Xiphophorus, Huiping Yang, Terrence R. Tiersch

Faculty Publications

Aquarium fishes are becoming increasingly important because of their value in biomedical research and the ornamental fish trade, and because many have become threatened or endangered in the wild. This review summarizes the current status of sperm cryopreservation in three fishes widely used in biomedical research: zebrafish, medaka, and live-bearing fishes of the genus Xiphophorus, and will focus on the needs and opportunities for future research and application of cryopreservation in aquarium fish. First, we summarize the basic biological characteristics regarding natural habitat, testis structure, spermatogenesis, sperm morphology, and sperm physiology. Second, we compare protocol development of sperm cryopreservation. Third, …