Digital Commons Network^™

Increasing Mortality In Adults With Diabetes And Low Estimated Glomerular Filtration Rate In The Absence Of Albuminuria, Holly Kramer, Robert E. Boucher, David Leehey, Linda Fried, Guo Wei, Tom Greene, Sylvia E. Rosas, Richard Cooper, Guichan Cao, Srinivasan Beddhu

Faculty Publications

OBJECTIVE Improved blood pressure control and use of renin-angiotensin-aldosterone system blockers have altered the clinical presentation or phenotype of chronic kidney disease (CKD) in U.S. adults with diabetes. These changes may influence mortality. RESEARCH DESIGN AND METHODS Data from theNationalHealth and Nutrition Examination Surveys (NHANES) 1988-2006 were used to examinemortality trends in adults with diabetes, defined as physician diagnosis, fasting glucose ≥126 mg/dL, HbA1c >6.5% (48 mmol/mol), or use of glucose-lowering medications. Mortality trends by CKD phenotype (estimated glomerular filtration rate [eGFR] and urine albumin-to-creatinine ratio [ACR] level)were obtained via linkage with the National Death Index through 31 December 2011 …

P62 As A Therapeutic Target For Inhibition Of Autophagy In Prostate Cancer, Lei Wang, Donghern Kim, James T.F. Wise, Xianglin Shi, Zhuo Zhang, Robert S. Dipaola

Faculty Publications

Background: To test the hypothesis that p62 is an optimal target for autophagy inhibition and Verteporfin, a clinically available drug approved by FDA to treat macular degeneration that inhibits autophagy by targeting p62 protein, can be developed clinically to improve therapy for advanced prostate cancer. Methods: Forced expression of p62 in PC-3 cells and normal prostate epithelial cells, RWPE-1 and PZ-HPV7, were carried out by transfection of these cells with pcDNA3.1/p62 or p62 shRNA plasmid. Autophagosomes and autophagic flux were measured by transfection of tandem fluorescence protein mCherry-GFP-LC3 construct. Apoptosis was measured by Annexin V/PI staining. Tumorigenesis was measured by …

The Long-Term Societal Impacts Of Conditional Cash Transfers: Bolsa Família A Decade In, Brian Warby

Faculty Publications

Conditional Cash Transfers (CCTs) are innovative poverty intervention programs that have been adapted and adopted in dozens of countries around the world. The effectiveness of the programs in the short-term have been established by a number of studies, but they have only recently been around long enough to begin to observe whether they indeed disrupt the inter-generational poverty cycle as claimed. The expected long-term effects are central to the appeal of CCT programs. This empirical study examines the data to determine whether there is evidence that the long-term effects are as apparent as the short-term effects in one of the …

Group Size In Physical Education: A Teachers' Perspective, David C. Barney, Robert Christenson Dr.

Faculty Publications

The physical education context is fun, yet challenging. There is the potential to offer a multitude of activities and games for students. Thus, PE teachers should put the students in the best position to learn the content. One method PE teachers can use is putting students in small-sided groups during game and activities. The purpose of this study was to investigate K-12 physical education teachers’ perceptions of small-sided games/activities in their PE lessons. For this study 31 K-12 physical educators from five states participated in the study. The PE teachers were emailed a survey for them to fill out. The …

Physical Activity Environment And Japanese Adults’ Body Mass Index, Mohammad Javad Koohsari, Andrew T. Kaczynski, Tomoya Hanibuchi, Ai Shibata, Kaori Ishii, Akitomo Yasunaga, Tomoki Nakaya, Koichiro Oka

Faculty Publications

Evidence about the impacts of the physical activity environment on adults’ weight in the context of Asian countries is scarce. Likewise, no study exists in Asia examining whether Walk Score^®—a free online walkability tool—is related to obesity. This study aimed to examine associations between multiple physical activity environment measures and Walk Score^® ratings with Japanese adults’ body mass index (BMI). Data from 1073 adults in the Healthy Built Environment in Japan study were used. In 2011, participants reported their height and weight. Environmental attributes, including population density, intersection density, density of physical activity facilities, access to public …

Dietary Inflammatory Index And Type 2 Diabetes Mellitus In Adults: The Diabetes Mellitus Survey Of Mexico City, Edgar Denova-Gutiérrez, Paloma Muñoz-Aguirre, Nitin Shivappa, James R. Hébert, Lizbeth Tolentino-Mayo, Carolina Batis, Simón Barquera

Faculty Publications

Diet and inflammation are both associated with type 2 diabetes mellitus (T2DM). In the present study, we aimed to assess the relation between the dietary inflammatory index (DII) and the presence of T2DM in Mexican adults participating in the Diabetes Mellitus Survey administered in Mexico City (DMS-MC). The study involved 1174 subjects (48.5% men) between 20–69 years of age. A validated semi-quantitative food frequency questionnaire was employed to evaluate dietary intake and to compute DII. The DII is based on scientific evidence about the association between dietary compounds and six established inflammatory biomarkers. Multivariate logistic regression models were used to …

Andale Pittsburgh: Results Of A Promotoraled, Home-Based Intervention To Promote A Healthy Weight In Latino Preschool Children, Sharon E. Taverno Ross, Bethany Barone Gibbs, Patricia I. Documet, Russell R. Pate

Faculty Publications

Background: Latino preschool children have higher rates of obesity than preschool children from other racial/ ethnic groups; however, few effective, culturally appropriate interventions exist targeting this group. The purpose of this study was to test the feasibility of a 10-week, promotora-mediated, home-based intervention to promote a healthy weight in Latino preschool children.

Methods: Trained promotoras (community health workers) delivered 10, 90-min weekly interactive and tailored sessions to Latino families living in Allegheny County. Participants were recruited through promotoras’ own social networks and community gatherings, flyers, and word of mouth. Primary outcome measures included child body mass index (BMI) z-score and …

Characterizing The Phylogenetic Specialism-Generalism Spectrum Of Mammal Parasites, A. W. Park, M. J. Farrell, J. P. Schmidt, S. Huang, T. A. Dallas, P. Pappalardo, J. M. Drake, P. R. Stephens, R. Poulin, C. L. Nunn, T. J. Davies

Faculty Publications

© 2018 The Author(s) Published by the Royal Society. All rights reserved. The distribution of parasites across mammalian hosts is complex and represents a differential ability or opportunity to infect different host species. Here, we take a macroecological approach to investigate factors influencing why some parasites show a tendency to infect species widely distributed in the host phylogeny (phylogenetic generalism) while others infect only closely related hosts. Using a database on over 1400 parasite species that have been documented to infect up to 69 terrestrialmammal host species,we characterize the phylogenetic generalism of parasites using standard effect sizes for three metrics: …

Limit-Feeding Dairy Heifers: More Efficient Feeding Can Lead To Reduced Costs, Peter S. Erickson

Faculty Publications

No abstract provided.

Community Assembly Of The Ferns Of Florida, Emily B. Sessa, Sally M. Chambers, Daijiang Li, Lauren Trotta, Lorena Endara, J. Gordon Burleigh, Benjamin Baiser

Faculty Publications

© 2018 The Authors. American Journal of Botany is published by Wiley Periodicals, Inc. on behalf of the Botanical Society of America. Premise of the Study: Many ecological and evolutionary processes shape the assembly of organisms into local communities from a regional pool of species. We analyzed phylogenetic and functional diversity to understand community assembly of the ferns of Florida at two spatial scales. Methods: We built a phylogeny for 125 of the 141 species of ferns in Florida using five chloroplast markers. We calculated mean pairwise dissimilarity (MPD) and mean nearest taxon distance (MNTD) from phylogenetic distances and functional …

Cd Obesity-Prone Rats, But Not Obesity-Resistant Rats, Robustly Ferment Resistant Starch Without Increased Weight Or Fat Accretion, Diana Obanda, Ryan Page, Justin Guice, Anne M. Raggio, Claudia Husseneder, Brian Marx, Rhett W. Stout, David A. Welsh, Christopher M. Taylor, Meng Luo, Eugene E. Blanchard, Zach Bendiks, Diana Coulon, Michael J. Keenan

Faculty Publications

© 2018 The Obesity Society Objective: This study used CD obesity-prone (OP) and obesity-resistant (OR) rats to examine how weight gain and fat accretion relate to fermentation levels and microbiota composition after feeding resistant starch (RS). Methods: After feeding OP rats and OR rats a high-fat (HF) diet for 4 weeks, rats were stratified into three groups: they were fed either an HF diet (group 1: HF-HF) or were switched to a low-fat (LF) diet (group 2: HF-LF) or an LF diet supplemented with 20% RS by weight for 4 weeks (group 3: HF-LFRS). Energy intake, body weight, fermentation variables, …

Cd Obesity-Prone Rats, But Not Obesity-Resistant Rats, Robustly Ferment Resistant Starch Without Increased Weight Or Fat Accretion, Diana Obanda, Ryan Page, Justin Guice, Anne M. Raggio, Claudia Husseneder, Brian Marx, Rhett W. Stout, David A. Welsh, Christopher M. Taylor, Meng Luo, Eugene E. Blanchard, Zach Bendiks, Diana Coulon, Michael J. Keenan

Faculty Publications

© 2018 The Obesity Society Objective: This study used CD obesity-prone (OP) and obesity-resistant (OR) rats to examine how weight gain and fat accretion relate to fermentation levels and microbiota composition after feeding resistant starch (RS). Methods: After feeding OP rats and OR rats a high-fat (HF) diet for 4 weeks, rats were stratified into three groups: they were fed either an HF diet (group 1: HF-HF) or were switched to a low-fat (LF) diet (group 2: HF-LF) or an LF diet supplemented with 20% RS by weight for 4 weeks (group 3: HF-LFRS). Energy intake, body weight, fermentation variables, …

Trans-Ethnic Analysis Of Metabochip Data Identifies Two New Loci Associated With Bmi, J. Gong, K. K. Nishimura, L. Fernandez-Rhodes, J. Haessler, S. Bien, M. Graff, U. Lim, Y. Lu, M. Gross, M. Fornage, S. Yoneyama, C. R. Isasi, P. Buzkova, M. Daviglus, D. Y. Lin, R. Tao, R. Goodloe, W. S. Bush, E. Farber-Eger, J. Boston, H. H. Dilks, G. Ehret, C. C. Gu, C. E. Lewis, K. D.H. Nguyen, R. Cooper, M. Leppert, M. R. Irvin, E. P. Bottinger, L. R. Wilkens, C. A. Haiman, L. Park, K. R. Monroe

Faculty Publications

Objective:Body mass index (BMI) is commonly used to assess obesity, which is associated with numerous diseases and negative health outcomes. BMI has been shown to be a heritable, polygenic trait, with close to 100 loci previously identified and replicated in multiple populations. We aim to replicate known BMI loci and identify novel associations in a trans-ethnic study population.Subjects:Using eligible participants from the Population Architecture using Genomics and Epidemiology consortium, we conducted a trans-ethnic meta-analysis of 102 514 African Americans, Hispanics, Asian/Native Hawaiian, Native Americans and European Americans. Participants were genotyped on over 200 000 SNPs on the Illumina Metabochip custom …

Integrating Nutrition Into Health Systems At Community Level:Impact Evaluation Of The Community‐Based Maternal Andneonatal Health And Nutrition Projects In Ethiopia, Kenya, And Senegal, Jacqueline K. Kung'u, Richard Pendame, Mame Bineta Ndiaye, Mulusew Gerbaba, Sophie Ochola, Adama Faye, Sulochana Basnet, Edward A. Frongillo Jr., Sara Wuehler, Luz Maria De‐Regil

Faculty Publications

Maternal undernutrition and mortality remain high in several African countries. Key nutrition andhealth interventions improve maternal and birth outcomes. Evidence is scarce on how tostrengthen health systems to ensure pregnant women and newborns are reached with theseinterventions. We conducted three quasi‐experimental nonrandomized Community BasedMaternal and Neonatal Health and Nutrition projects in regions of Ethiopia, Senegal, and Kenyato demonstrate how proven nutrition interventions could be integrated into health programs toimprove knowledge and practices during pregnancy, birth, and postpartum. We evaluated impacton knowledge and practices related to maternal and neonatal care using logistic regression andrepeated‐measures models with districts as a fixed variable …

Detection Of Antibiotic Resistance Toxigenic Clostridium Difficile In Processed Retail Lettuce, Yi Han, Joan King, Marlene E. Janes

Faculty Publications

Objectives: Clostridium difficile is the major cause of infectious diarrhoea in humans after antimicrobial treatment. Clostridium difficile has been isolated from food animals and meat. The main purpose of this study was to characterize C. difficile isolated from retail lettuce and determine the antibiotic resistance using five common clinical-selected antibiotics (metronidazole, vancomycin, clindamycin, erythromycin, and cefotaxime). Materials and Methods: Lettuce samples (grown in California, Arkansas, and Louisiana) were purchased from retail stores. Results: Toxigenic C. difficile was isolated from 13.8 per cent (41/297) of the lettuce samples. Among the toxigenic isolates, only 82.9 per cent (34/41) produced toxin B, 17.1 …

Pilot Study Of The Tart Cherry Juice For The Treatment Of Insomnia And Investigation Of Mechanisms, Jack N. Losso, John W. Finley, Namrata Karki, Ann G. Liu, Alfredo Prudente, Russell Tipton, Ying Yu, Frank L. Greenway

Faculty Publications

Background: Insomnia is common in the elderly and is associated with chronic disease, but use of hypnotics increases the incidence of falls. Montmorency tart cherry juice has improved insomnia by self-report questionnaire. Study Question: Is insomnia confirmed by polysomnography and is tryptophan availability a potential mechanism for treating insomnia? Study Design: A placebo-controlled balanced crossover study with subjects older than 50 years and insomnia were randomized to placebo (2 weeks) or cherry juice (2 weeks) (240 mL 2 times/d) separated by a 2-week washout. Measures and Outcomes: Sleep was evaluated by polysomnography and 5 validated questionnaires. Serum indoleamine 2,3-dioxygenase (IDO), …

Identifying Apparent Local Stable Isotope Equilibrium In A Complex Non-Equilibrium System, Yuyang He, Xiaobin Cao, Jianwei Wang, Huiming Bao

Faculty Publications

Copyright © 2017 John Wiley & Sons, Ltd. Rationale: Although being out of equilibrium, biomolecules in organisms have the potential to approach isotope equilibrium locally because enzymatic reactions are intrinsically reversible. A rigorous approach that can describe isotope distribution among biomolecules and their apparent deviation from equilibrium state is lacking, however. Methods: Applying the concept of distance matrix in graph theory, we propose that apparent local isotope equilibrium among a subset of biomolecules can be assessed using an apparent fractionation difference (|Δα|) matrix, in which the differences between the observed isotope composition (δ') and the calculated equilibrium fractionation factor (1000lnβ) …

Identifying Apparent Local Stable Isotope Equilibrium In A Complex Non-Equilibrium System, Yuyang He, Xiaobin Cao, Jianwei Wang, Huiming Bao

Faculty Publications

Copyright © 2017 John Wiley & Sons, Ltd. Rationale: Although being out of equilibrium, biomolecules in organisms have the potential to approach isotope equilibrium locally because enzymatic reactions are intrinsically reversible. A rigorous approach that can describe isotope distribution among biomolecules and their apparent deviation from equilibrium state is lacking, however. Methods: Applying the concept of distance matrix in graph theory, we propose that apparent local isotope equilibrium among a subset of biomolecules can be assessed using an apparent fractionation difference (|Δα|) matrix, in which the differences between the observed isotope composition (δ') and the calculated equilibrium fractionation factor (1000lnβ) …

Effects Of Cardiorespiratory Fitness And Weight Status On Knowledge Of Physical Activity And Fitness, Attitude Toward Physical Education, And Physical Activity, Senlin Chen, Xiangli Gu

Faculty Publications

Background: The purpose of this study was to examine the effects of cardiorespiratory fitness and weight status on knowledge of physical activity and fitness (PAF knowledge), attitude toward physical education (PE), and physical activity. Methods: A total of 343 middle school students participated in the study (Age: M/SD = 12.76/.94, ranging from 11 to 14 years old). PE Metrics™ was used to measure PAF knowledge, and Attitude toward Physical Education Questionnaire and Youth Activity Profile were used to measure attitude, physical activity and sedentary behavior. Fitness and weight status were assessed using FitnessGram and converted to in Healthy Fitness Zone …

Heart Rate-Defined Sustained Attention In Infants At Risk For Autism, Bridgette L. Tonnsen, J. E. Richards, Jane E. Roberts

Faculty Publications

Background: Although aberrant visual attention has been identified in infants at high familial risk for autism, the developmental emergence of atypical attention remains unclear. Integrating biological measures of attention into prospective high-risk infant studies may inform more nuanced developmental trajectories, clarifying the onset and course of atypical attention and potentially advancing early screening or treatment protocols. Heart rate-defined sustained attention (HRDSA) is a well-validated biological measure of attentional engagement that, in non-clinical infant populations, provides incremental information about attentional engagement beyond looking behaviors alone. The present study aimed to examine the characteristics and clinical correlates of HRDSA in high-risk infants, …

Hypertension, Genes, And Environment: Challenges For Prevention And Risk Prediction, Richard Cooper

Faculty Publications

No abstract provided.

Dietary Inflammatory Index And Cardiovascular Risk And Mortality—A Meta-Analysis, Nitin Shivappa, Justyna Godos, James R. Hébert, Michael Wirth, Gabriele Piuri, Attilio Speciani, Giuseppe Grosso

Faculty Publications

Diet and chronic inflammation have been suggested to be risk factors in the development of cardiovascular disease (CVD) and related mortality. The possible link between the inflammatory potential of diet measured through the Dietary Inflammatory Index (DII^®) and CVD has been investigated in several populations across the world. The aim of this study was to conduct a meta-analysis on studies exploring this association. Data from 14 studies were eligible, of which two were case-control, eleven were cohort, and one was cross-sectional. Results from the random-effects meta-analysis showed a positive association between increasing DII, indicating a pro-inflammatory diet, and …

Increasing Research Capacity In Underserved Communities: Formative And Summative Evaluation And Summative Evaluation Of The Mississippi Community Research Fellows Training Program (Cohort 1), Danielle Fastring, Susan Mayfield-Johnson, Tanya Funchess, Candice Green, Victoria Walker, Georgette Powell

Faculty Publications

Background: The Mississippi Community Research Fellows Training Program (MSCRFTP) is a 15-week program conducted in Jackson, MS, USA consisting of training in the areas of evidence-based public health, research methods, research ethics, and cultural competency. The purpose of the program was to increase community knowledge and understanding of public health research, develop community-based projects that addressed health disparity in the participants’ community, increase individual and community capacity, and to engage community members as equal partners in the research process.

Methods: A comprehensive evaluation of the MSCRFTP was conducted that included both quantitative and qualitative methods. All participants were asked to …

Lower Dietary Inflammatory Index Scores Are Associated With Lower Glycemic Index Scores Among College Students, Yeonsoo Kim, Jie Chen, Michael Wirth, Nitin Shivappa, James R. Hébert

Faculty Publications

The association between the Dietary Inflammatory Index (DII^®), the glycemic index (GI), and the glycemic load (GL) is not known, although it is known that carbohydrates are pro-inflammatory. We aimed to measure the association between the DII and both GI and GL among college students. In this cross-sectional study, 110 college students completed a 3-day food diary, which was used to calculate the DII, the GI, the GL, and the healthy eating index (HEI)-2010. Least square means and 95% confidence intervals of the GI, the GL, and the HEI-2010 were presented per DII tertile using generalized linear mixed …

Stepping It Up: Walking Behaviors In Children Transitioning From 5th To 7th Grade, Sharon E. Taverno Ross, Morgan N. Clennin, Marsha Dowda, Natalie Colabianchi, Russell R. Pate

Faculty Publications

The purpose of this study was to (1) describe children’s walking behaviors in 5th to 7th grade and change over time and (2) examine associations between walking behaviors and Walk Score®. Participants consisted of n = 586 students from the Transitions and Activity Changes in Kids (TRACK) Study. Children reported any walking behavior (e.g., exercise and transportation) over the past five days. Walk Score was calculated based on children’s home address. Descriptive statistics summarized walking behaviors by gender and time, and repeated measure mixed models examined the relationship between walking behaviors and Walk Score. Approximately 46.8% and 19.2% of 5th …

A Strategy For Sperm Cryopreservation Of Atlantic Salmon, Salmo Salar, For Remote Commercial-Scale High-Throughput Processing, Huiping Yang, E. Hu, John T. Buchanan, Terrence R. Tiersch

Faculty Publications

Sperm cryopreservation is an essential tool for long-term storage of genetic resources for aquaculture fishes. The goal of this study was to develop an efficient and streamlined protocol for high-throughput processing for sperm cryopreservation in Atlantic salmon, Salmo salar. The objectives were to evaluate: (1) osmolality of blood serum for determining extender osmolality, (2) effects of extenders for fresh sperm dilution and refrigerated storage, (3) effects of methanol and dimethyl sulfoxide (DMSO) on fresh sperm motility, and (4) motility and fertility after thawing. In this study, sperm samples were collected at a hatchery site in Canada and shipped to a …

A Three Year Study Of Metal Levels In Skin Biopsies Of Whales In The Gulf Of Mexico After The Deepwater Horizon Oil Crisis, John Pierce Wise, James T.F. Wise, Catherine F. Wise, Sandra S. Wise, Christy Gianios, Hong Xie, Ron Walter, Mikki Boswell, Cairong Zhu, Tongzhang Zheng, Christopher Perkins, John Pierce Wise

Faculty Publications

In response to the explosion of the Deepwater Horizon and the massive release of oil that followed, we conducted three annual research voyages to investigate how the oil spill would impact the marine offshore environment. Most investigations into the ecological and toxicological impacts of the Deepwater Horizon Oil crisis have mainly focused on the fate of the oil and dispersants, but few have considered the release of metals into the environment. From studies of previous oil spills, other marine oil industries, and analyses of oil compositions, it is evident that metals are frequently encountered. Several metals have been reported in …

In Vitro Digestible Properties And Quality Characterization Of Nonsucrose Gluten-Free Lentinus Edodes Cookies, Tao Feng, Wenxin Wang, Haining Zhuang, Shiqing Song, Lingyun Yao, Min Sun, Zhimin Xu

Faculty Publications

Lentinus edodes was included in nonsucrose gluten-free cookie formulations. Their digestible properties and quality features were analyzed. Six various types of cookies were prepared through the use of 0, 5, 10, 15, 20, and 25% of Lentinus edodes powder. The quality features of cookies and cookie dough, as well as digestibility were measured. To which level consumers were attracted by the six types of cookie was assessed. The quality features of the six types of cookies varied significantly to different degrees. Nevertheless, these differences failed to change the acceptance of consumers for nonsucrose gluten-free Lentinus edodes cookies. The digestibility properties …

Trade-Offs And Synergies Of Ecosystem Services In The Taihu Lake Basin Of China, Xuning Qiao, Yangyang Gu, Changxin Zou, Lei Wang, Juhua Luo, Xianfeng Huang

Faculty Publications

Understanding the spatial interactions among multiple ecosystem services is crucial for ecosystem services management. Ecosystem services, including crop production, freshwater supply, aquatic production, net primary production, soil conservation, water conservation, flood regulation, forest recreation, were measured at 1-km grid scale covering the Taihu Lake Basin (TLB) of China. Our objective is to get a comprehensive understanding of the spatial distributions, trade-offs, synergies of multiple ecosystem services across the TLB. Our results found that: 1) majority of ecosystem services were clustered in space and had a similar spatial distribution pattern with the geographical resource endowment. Most of the landscape contributed a …

The Effect Of The Ehealth Intervention ‘Myplan 1.0’ On Physical Activity In Adults Who Visit General Practice: A Quasi-Experimental Trial, Laurent Degroote, Jolien Plaete, Ilse De Bourdeaudhuij, Maïté Verloigne, Vicky Van Stappen, An V. De Meester, Louise Poppe, Celien Van Der Mispel, Geert Crombez

Faculty Publications

Physical inactivity is one of the major risk factors for poor health in the world. Therefore, effective interventions that promote physical activity are needed. Hence, we developed an eHealth intervention for adults, i.e., ‘MyPlan 1.0’, which includes self-regulation techniques for behaviour change. This study examined the effect of ‘MyPlan 1.0’ on physical activity (PA) levels in general practice. 615 adults (≥18 years) were recruited in 19 Flemish general practices, for the intervention group (n = 328) or for the wait-list control group (n = 183). Participants in the intervention group received the web-based intervention ‘MyPlan 1.0’ and were prompted to …