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Articles 781 - 810 of 8281
Full-Text Articles in Entire DC Network
Oxidation 1-Methyl Naphthalene Based On The Synergy Of Environmentally Persistent Free Radicals (Epfrs) And Pahs In Particulate Matter (Pm) Surface, Ajit Ghimire, Farhana Hasan, Xia Guan, Phillip Potter, Chuqi Guo, Slawo Lomnicki
Oxidation 1-Methyl Naphthalene Based On The Synergy Of Environmentally Persistent Free Radicals (Epfrs) And Pahs In Particulate Matter (Pm) Surface, Ajit Ghimire, Farhana Hasan, Xia Guan, Phillip Potter, Chuqi Guo, Slawo Lomnicki
Faculty Publications
Studies of the environmental fate through the interactions of particle-associated polycyclic aromatic hydrocarbons (PAHs) with environmentally persistent free radicals (EPFRs) are presented. The formation of PAHs and EPFRs typically occurs side by side during combustion-processes. The laboratory simulation studies of the model PAH molecule 1-Methylnaphthalene (1-MN) interaction with model EPFRs indicate a transformational synergy between these two pollutants due to mutual and matrix interactions. EPFRs, thorough its redox cycle result in the oxidation of PAHs into oxy-/hydroxy-PAHs. EPFRs have been shown before to produce OH radical during its redox cycle in aqueous media and this study has shown that produced …
Influences Of Yogurt With Functional Ingredients From Various Sources That Help Treat Leaky Gut On Intestinal Barrier Dysfunction In Caco-2 Cells, Ricardo S. Aleman, Ryan Page, Roberto Cedillos, Ismael Montero-Fernández, Jhunior Abraham Marcia Fuentes, Douglas W. Olson, Kayanush Aryana
Influences Of Yogurt With Functional Ingredients From Various Sources That Help Treat Leaky Gut On Intestinal Barrier Dysfunction In Caco-2 Cells, Ricardo S. Aleman, Ryan Page, Roberto Cedillos, Ismael Montero-Fernández, Jhunior Abraham Marcia Fuentes, Douglas W. Olson, Kayanush Aryana
Faculty Publications
The impact of yogurts made with starter culture bacteria (L. bulgaricus and S. thermophilus) and supplemented with ingredients (maitake mushrooms, quercetin, L-glutamine, slippery elm bark, licorice root, N-acetyl-D-glucosamine, zinc orotate, and marshmallow root) that can help treat leaky gut were investigated using the Caco-2 cell monolayer as a measure of intestinal barrier dysfunction. Milk from the same source was equally dispersed into nine pails, and the eight ingredients were randomly allocated to the eight pails. The control had no ingredients. The Caco-2 cells were treated with isoflavone genistein (negative control) and growth media (positive control). Inflammation was stimulated using an …
Looking Back To Look Forward: Exploring Crenshaw’S Political, Structural, And Representational Intersectionality In Sport, Allison Anders Ph.D., James M. Devita, Leslee A. Fisher, Chris Corr, Christina L. Myers
Looking Back To Look Forward: Exploring Crenshaw’S Political, Structural, And Representational Intersectionality In Sport, Allison Anders Ph.D., James M. Devita, Leslee A. Fisher, Chris Corr, Christina L. Myers
Faculty Publications
Engaging with Kimberlé Crenshaw’s concept of intersectionality, the authors (re)turn to its genesis in critical race theory (CRT) and specifically, its forms of structural intersectionality, political intersectionality, and representational intersectionality. Discussing each form in relation to contemporary issues in sport that Black women and women of Color navigate, they argue that Crenshaw’s intersectionality provides additional compelling layers of engagement with existing intersectional scholarship and scholarship about activism in sport, invites structural and discursive change through intersectional policies and practice, and promotes coalition building toward intersectional racial justice in sport.
Editorial Introduction: Exploring Policy Theories, Narratives, And Policing, Geoboo Song, Melissa K. Merry, Holly L. Peterson, Davor Mondom, Briana Huett, Izehi Oriaghan, Creed Tumlison, Camille Gilmore, Gwen Arnold, Aaron Smith-Walter, Saba Siddiki, Heasun Choi
Editorial Introduction: Exploring Policy Theories, Narratives, And Policing, Geoboo Song, Melissa K. Merry, Holly L. Peterson, Davor Mondom, Briana Huett, Izehi Oriaghan, Creed Tumlison, Camille Gilmore, Gwen Arnold, Aaron Smith-Walter, Saba Siddiki, Heasun Choi
Faculty Publications
No abstract provided.
Second Amendment Exceptionalism: Public Expression And Public Carry, Timothy Zick
Second Amendment Exceptionalism: Public Expression And Public Carry, Timothy Zick
Faculty Publications
In New York State Rifle & Pistol Ass’n v. Bruen, the Supreme Court recognized a right to carry firearms in public places. The scope of that right will depend on where, why, and how governments regulated public carry during the eighteenth and perhaps nineteenth centuries. The Court claimed that its turn to history for determining the scope of Second Amendment rights “accords with” and “comports with” how the Court has interpreted First Amendment rights. This Article examines and rejects that claim, both in general and specifically as it applies to the public exercise of Second Amendment rights. Although Bruen …
The Independent Agency Myth, Neal Devins, David E. Lewis
The Independent Agency Myth, Neal Devins, David E. Lewis
Faculty Publications
Republicans and Democrats are fighting the wrong fight over independent agencies. Republicans are wrong to see independent agencies as anathema to hierarchical presidential control of the administrative state. Democrats are likewise wrong to reflexively defend independent agency expertise and influence. Supreme Court Justices also need to break free from this trap; the ongoing struggle over independent agencies should be about facts, not partisan rhetoric.
This Article seeks to reframe the fight over independent agencies. By surveying executive branch and independent agency department heads and supervisors during the Obama (2014) and Trump (2020) administrations, we have assembled unique and expansive data …
The Chatgpt Artificial Intelligence Chatbot: How Well Does It Answer Accounting Assessment Questions?, David A. Wood, Ryan D. Sommerfeldt, Muskan P. Achhpilia, Mollie T. Adams, Sanaz Aghazadeh, William G. Heninger, Jeffrey Pickerd, Jon Kerr
The Chatgpt Artificial Intelligence Chatbot: How Well Does It Answer Accounting Assessment Questions?, David A. Wood, Ryan D. Sommerfeldt, Muskan P. Achhpilia, Mollie T. Adams, Sanaz Aghazadeh, William G. Heninger, Jeffrey Pickerd, Jon Kerr
Faculty Publications
ChatGPT, a language-learning model chatbot, has garnered considerable attention for its ability to respond to users’ questions. Using data from 14 countries and 186 institutions, we compare ChatGPT and student performance for 28,085 questions from accounting assessments and textbook test banks. As of January 2023, ChatGPT provides correct answers for 56.5 percent of questions and partially correct answers for an additional 9.4 percent of questions. When considering point values for questions, students significantly outperform ChatGPT with a 76.7 percent average on assessments compared to 47.5 percent for ChatGPT if no partial credit is awarded and 56.5 percent if partial credit …
Relations Among Bitcoin Futures, Bitcoin Spot, Investor Attention, And Sentiment, Arun Narayanasamy, Humnath Panta, Rohit Agarwal
Relations Among Bitcoin Futures, Bitcoin Spot, Investor Attention, And Sentiment, Arun Narayanasamy, Humnath Panta, Rohit Agarwal
Faculty Publications
This research investigates the function of price discovery between the Bitcoin futures and the spot markets while also analyzing the impact of investor sentiment and attention on these markets. This study utilizes various statistical models to examine the short-term and long-term relations between these variables, including the bivariate Granger causality model, the ARDL and NARDL models, and the Johansen cointegration procedure with a vector error correction mechanism. The results suggest that there is no statistical evidence of price discovery between the Bitcoin spot price and futures, and the term structure of the Bitcoin futures neither enriches nor impairs this lead …
Estudio Descriptivo De La Comunicación Interna De Una Institución De Educación Superior En Montemorelos, Nuevo León, Paola Isabel Hernandez Juarez, Karla Sarai Basurto Gutierrez
Estudio Descriptivo De La Comunicación Interna De Una Institución De Educación Superior En Montemorelos, Nuevo León, Paola Isabel Hernandez Juarez, Karla Sarai Basurto Gutierrez
Faculty Publications
El objetivo de la presente investigación fue conocer el grado de comunicación interna de una institución de nivel superior en Montemorelos, Nuevo León. La población fue de 370 empleados de los cuales se encuestó a 107. El estudio fue cuantitativo, descriptivo, exploratorio y transversal. Para la recolección de datos se adaptó el cuestionario hecho por Rivera Martínez (2019). Este cuestionario contiene una escala para la medición de la comunicación interna y consta de 17 ítems valorados por una escala de siete puntos en la escala de Likert que va desde 1. pésima a 7. excelente. El nivel de confiabilidad se …
Entorhinal Cortical Delta Oscillations Drive Memory Consolidation, Juhee Haam, Suman Gunin, Leslie Wilson, Sydney Fry, Briana Bernstein, Eric Thomson, Hayden Noblet, Jesse Cushman, Jerrel L. Yakel
Entorhinal Cortical Delta Oscillations Drive Memory Consolidation, Juhee Haam, Suman Gunin, Leslie Wilson, Sydney Fry, Briana Bernstein, Eric Thomson, Hayden Noblet, Jesse Cushman, Jerrel L. Yakel
Faculty Publications
Long-term memories are formed by creating stable memory representations via memory consolidation, which mainly occurs during sleep following the encoding of labile memories in the hippocampus during waking. The entorhinal cortex (EC) has intricate connections with the hippocampus, but its role in memory consolidation is largely unknown. Using cell-type- and input-specific in vivo neural activity recordings, here we show that the temporoammonic pathway neurons in the EC, which directly innervate the output area of the hippocampus, exhibit potent oscillatory activities during anesthesia and sleep. Using in vivo individual and populational neuronal activity recordings, we demonstrate that a subpopulation of the …
Μconadapter: Reinforcement Learning-Based Fast Concurrency Adaptation For Microservices In Cloud, Jianshu Liu, Shungeng Zhang, Qingyang Wang
Μconadapter: Reinforcement Learning-Based Fast Concurrency Adaptation For Microservices In Cloud, Jianshu Liu, Shungeng Zhang, Qingyang Wang
Faculty Publications
Modern web-facing applications such as e-commerce comprise tens or hundreds of distributed and loosely coupled microservices that promise to facilitate high scalability. While hardware resource scaling approaches [28] have been proposed to address response time fluctuations in critical microservices, little attention has been given to the scaling of soft resources (e.g., threads or database connections), which control hardware resource concurrency. This paper demonstrates that optimal soft resource allocation for critical microservices significantly impacts overall system performance, particularly response time. This suggests the need for fast and intelligent runtime reallocation of soft resources as part of microservices scaling management. We introduce …
140 Characters To Justice? The Promise And Perils Of Using Social Media To Reveal Lay Punishment Perspectives, Itay Ravid, Rotem Dror
140 Characters To Justice? The Promise And Perils Of Using Social Media To Reveal Lay Punishment Perspectives, Itay Ravid, Rotem Dror
Faculty Publications
For centuries, penal theorists have debated two key criminal justice questions: justifying state punishment power and determining proper punishment levels. Moral philosophers offered several theories to address these questions. Over time, calls emerged to move beyond theories and to consider community views on punishment rationales in criminal law and policy design, an approach that gained support alongside meaningful critique. Concurrently, social science advancements enabled empirically deepening understanding of public attitudes about punishment, largely through surveys and experiments.
One domain, however, remained untouched by those calling to assess lay intuitions of justice: social media. Such oversight is puzzling in light of …
Virtual Criminal Law Dualism, Itay Ravid, Hadar Dancig-Rosenberg
Virtual Criminal Law Dualism, Itay Ravid, Hadar Dancig-Rosenberg
Faculty Publications
Since the start of the new millennium, technological and societal changes have initiated a transition from physical to virtual spaces. This farreaching phenomenon has extended to the law and legal institutions, including the criminal law domain. This essay coins the term “virtual criminal law dualism” to describe the dynamic relationship between the virtual and physical spaces in the criminal law sphere. We contend that the transition to virtual spaces has manifested in two distinct aspects. The first relates to formal doctrinal, procedural, and institutional changes that the mainstream criminal law and procedure have undergone due to the emergence of virtual …
Directing The Stereoselectivity Of The Claisen Rearrangement To Form Cyclic Ketones With Full Substitution At The Α-Positions, Fatimat O. Badmus, Raju S. Thombal, Satish Chandra Philkhana, Joshua A. Malone, Christian E. Bailey, Estefania Armendariz-Gonzalez, Edward W. Mureka, Cale M. Locicero, Frank R. Fronczek, Rendy Kartika
Directing The Stereoselectivity Of The Claisen Rearrangement To Form Cyclic Ketones With Full Substitution At The Α-Positions, Fatimat O. Badmus, Raju S. Thombal, Satish Chandra Philkhana, Joshua A. Malone, Christian E. Bailey, Estefania Armendariz-Gonzalez, Edward W. Mureka, Cale M. Locicero, Frank R. Fronczek, Rendy Kartika
Faculty Publications
We report an enantioselective synthesis of cyclic ketones with full substitutions at the α-positions in a highly diastereoselective manner. Our method is achieved by subjecting substrate motifs in 2-allyloxyenones to chiral organomagnesium reagents, which trigger the Claisen rearrangement upon direct 1,2-carbonyl addition. The observed diastereoselectivity of the allyl migration is proposed to originate from the intramolecular chelation of the magnesium alkoxide to the allyloxy moiety.
Creating An Inclusive Metadata Policy, Nicole Lewis, Jeremy Myntti
Creating An Inclusive Metadata Policy, Nicole Lewis, Jeremy Myntti
Faculty Publications
The BYU Library is creating an Inclusive Metadata Policy for metadata creators to use when creating and remediating descriptions to be more inclusive. Accompanying the policy is a companion document with recommendations and examples, including links to many external resources. In addition to working with stakeholders in the library to develop the policy, we consulted with the University’s Office of Belonging. This presentation describes the process we used to undertake the creation of the library policy and recommendations document.
Ready Worker One? High-Res Vr For The Home Office, Anastasia Ruvimova, Felipe Fronchetti, Boden A. Kahn, Luiz Henrique Susin, Zekeya Hurley, Thomas Fritz, Mark Hancock, David Shepherd
Ready Worker One? High-Res Vr For The Home Office, Anastasia Ruvimova, Felipe Fronchetti, Boden A. Kahn, Luiz Henrique Susin, Zekeya Hurley, Thomas Fritz, Mark Hancock, David Shepherd
Faculty Publications
Many employees prefer to work from home, yet struggle to squeeze their office into an already fully-utilized space. Virtual Reality (VR) seemingly offered a solution with its ability to transform even modest physical spaces into spacious, productive virtual offices, but hardware challenges - such as low resolution - have prevented this from becoming a reality. Now that hardware issues are being overcome, we are able to investigate the suitability of VR for daily work. To do so, we (1) studied the physical space that users typically dedicate to home offices and (2) conducted an exploratory study of users working in …
Noise In The Ligo Livingston Gravitational Wave Observatory Due To Trains, J. Glanzer, S. Soni, J. Spoon, A. Effler, G. González
Noise In The Ligo Livingston Gravitational Wave Observatory Due To Trains, J. Glanzer, S. Soni, J. Spoon, A. Effler, G. González
Faculty Publications
Environmental seismic disturbances limit the sensitivity of LIGO gravitational wave detectors. Trains near the LIGO Livingston detector produce low frequency (0.5- 10 H z ) ground noise that couples into the gravitational wave sensitive frequency band (10- 100 H z ) through light reflected in mirrors and other surfaces. We investigate the effect of trains during the Advanced LIGO third observing run, and propose a method to search for narrow band seismic frequencies responsible for contributing to increases in scattered light. Through the use of the linear regression tool Lasso (least absolute shrinkage and selection operator) and glitch correlations, we …
Class Size Determination And Decision Making In Lis Online Education, Lucy Santos Green, Kim M. Thompson, Nicole A. Cooke
Class Size Determination And Decision Making In Lis Online Education, Lucy Santos Green, Kim M. Thompson, Nicole A. Cooke
Faculty Publications
The purpose of this study was to develop a national landscape of the decisions made by LIS programs regarding online course enrollment caps. Online education expands learning opportunities for all students and is particularly attractive to nontraditional students who are more likely to have employment and family obligations that make attending traditional face-to-face classes difficult. At the same time, online learning can exacerbate existing opportunity gaps between certain student groups, depending on how well-prepared students are for online learning. This survey methodology study investigated course enrollment caps and the reasons behind the limits placed by Master of Library and Information …
Political Polarization In America: Its Impact On Industrial Democracy And Labor Law, Rafael Gely
Political Polarization In America: Its Impact On Industrial Democracy And Labor Law, Rafael Gely
Faculty Publications
This article explores the impact that political polarization is having in the social, legal, and regulatory space, particularly on American worker-management relations. Polarization is affecting decisions involving social relationships and market transactions, the ability of institutions built to generate debate and discussion to successfully complete these missions, and people's willingness to listen to and engage with views contrary to their own.
Message Or Messenger? Source And Labeling Effects In Authoritarian Response To Protest, Daniel Arnon, Pearce Edwards, Handi Li
Message Or Messenger? Source And Labeling Effects In Authoritarian Response To Protest, Daniel Arnon, Pearce Edwards, Handi Li
Faculty Publications
Authoritarian regimes in the 21st century have increasingly turned to using information control rather than kinetic force to respond to threats to their rule. This paper studies an often overlooked type of information control: strategic labeling and public statements by regime sources in response to protests. Labeling protesters as violent criminals may increase support for repression by signaling that protests are illegitimate and deviant. Regime sources, compared to more independent sources, could increase support for repression even more when paired with such an accusatory label. Accommodative labels should have opposing effects—decreasing support for repression. The argument is tested with a …
Qtls And Candidate Loci Associated With Drought Tolerance Traits Of Kaybonnet X Zhe733 Recombinant Inbred Lines Rice Population, Yheni Dwiningsih, Julie Thomas, Anuj Kumar, Chirag Gupta, Navdeep Gill, Charles Ruiz, Jawaher Alkahtani, Niranjan Baisakh, Andy Pereira
Qtls And Candidate Loci Associated With Drought Tolerance Traits Of Kaybonnet X Zhe733 Recombinant Inbred Lines Rice Population, Yheni Dwiningsih, Julie Thomas, Anuj Kumar, Chirag Gupta, Navdeep Gill, Charles Ruiz, Jawaher Alkahtani, Niranjan Baisakh, Andy Pereira
Faculty Publications
Rice is the most important staple crop for the sustenance of the world’s population, and drought is a major factor limiting rice production. Quantitative trait locus (QTL) analysis of drought-resistance-related traits was conducted on a recombinant inbred line (RIL) population derived from the self-fed progeny of a cross between the drought-resistant tropical japonica U.S. adapted cultivar Kaybonnet and the drought-sensitive indica cultivar ZHE733. K/Z RIL population of 198 lines was screened in the field at Fayetteville (AR) for three consecutive years under controlled drought stress (DS) and well-watered (WW) treatment during the reproductive stage. The effects of DS were quantified …
Deconstructing The Software Factory: A Practical Application Of Interorganizational Network Analysis, Zachary O. Ryan, Mark Reith, Clay Koschnick
Deconstructing The Software Factory: A Practical Application Of Interorganizational Network Analysis, Zachary O. Ryan, Mark Reith, Clay Koschnick
Faculty Publications
Over the past 5 years, the number of DoD software organizations that employ nontraditional organizational structures has increased. These organizations, commonly referred to as software factories, often employ the network-based organizational structures found within high-technology industries. This article details ways in which network analysis techniques can be used to create a big picture view of these nontraditional organizations. Drawing on methodologies employed by network researchers, the authors develop and present an interorganizational analysis process that highlights a program's social and economic structures. Following the case history approach, they demonstrate the applicability of this approach by analyzing an emergent DoD software …
Integrating Clinical Cancer And Ptm Proteomics Data Identifies A Mechanism Of Ack1 Kinase Activation, Eranga R. Balasooriya, Deshan Madhusanka, Tania P. López-Palacios, Riley J. Eastmond, Dasun Jayatunge, Jake J. Owen, Jack S. Gashler, Christina M. Egbert, Chanaka Bulathsinghalage, Lu Liu, Stephen R. Piccolo, Joshua L. Andersen
Integrating Clinical Cancer And Ptm Proteomics Data Identifies A Mechanism Of Ack1 Kinase Activation, Eranga R. Balasooriya, Deshan Madhusanka, Tania P. López-Palacios, Riley J. Eastmond, Dasun Jayatunge, Jake J. Owen, Jack S. Gashler, Christina M. Egbert, Chanaka Bulathsinghalage, Lu Liu, Stephen R. Piccolo, Joshua L. Andersen
Faculty Publications
Beyond the most common oncogenes activated by mutation (mut-drivers), there likely exists a variety of low-frequency mut-drivers, each of which is a possible frontier for targeted therapy. To identify new and understudied mut-drivers, we developed a machine learning (ML) model that integrates curated clinical cancer data and posttranslational modification (PTM) proteomics databases. We applied the approach to 62,746 patient cancers spanning 84 cancer types and predicted 3,964 oncogenic mutations across 1,148 genes, many of which disrupt PTMs of known and unknown function. The list of putative mut-drivers includes established drivers and others with poorly understood roles in cancer. This ML …
Friction-In-Design Regulation As 21st Century Time, Place, And Manner Restriction, Brett Frischmann, Susan Benesch
Friction-In-Design Regulation As 21st Century Time, Place, And Manner Restriction, Brett Frischmann, Susan Benesch
Faculty Publications
Digital networked society needs friction-in-design regulation that targets the digital architectures, supposedly smart (data-driven, algorithmic) systems, and interfaces that shape human interactions, behavior, and will (beliefs, preferences, values, intentions). The relentless push to eliminate friction for the sake of efficiency has hidden social costs that affect basic human capabilities and society. A general course correction is needed.
Friction in the digital networked environment can come in many forms. It can be as simple as a time delay prior to publishing a social media post, a notice that provides salient information coupled with a nudge toward actual deliberation, or a query …
Need-Oriented Evangelism: Encountering, Embracing, And Experiencing God, Petr Cincala, Allison Sauceda
Need-Oriented Evangelism: Encountering, Embracing, And Experiencing God, Petr Cincala, Allison Sauceda
Faculty Publications
This article provides a fresh perspective on evangelism by reflecting a belief in the Triune God--the source of saving truth and loving community. Mission is part of God’s nature; he is the ultimate Missionary. Mission happens naturally whenever children of God intentionally invite and facilitate God’s presence. Over time, the word “evangelism" has become contaminated by myths, a false understanding of God, and unpleasant religious experiences and practices. Genuine evangelism addresses the most burning issues of people’s lives and should be treated as such. True evangelism involves caring about, praying for, and sharing with people. The practical part of this …
Conservative Estimation Of Inertial Sensor Errors Using Allan Variance Data, Kyle A. Lethander, Clark N. Taylor
Conservative Estimation Of Inertial Sensor Errors Using Allan Variance Data, Kyle A. Lethander, Clark N. Taylor
Faculty Publications
To understand the error sources present in inertial sensors, both the white (time-invariant) and correlated noise sources must be properly characterized. To understand both sources, the standard approach (IEEE standards 647-2006, 952-2020) is to compute the Allan variance of the noise and then use human-based interpretation of linear trends to estimate the separate noise sources present in a sensor. Recent work has sought to overcome the graphical nature and visual-inspection basis of this approach leading to more accurate noise estimates. However, when using noise characterization in a filter, it is important that the noise estimates be not only accurate but …
Lightning Forecast From Chaotic And Incomplete Time Series Using Wavelet De-Noising And Spatiotemporal Kriging, Jared K. Nystrom, Raymond Hill, Andrew J. Geyer, Joseph J. Pignatiello Jr., Eric Chicken
Lightning Forecast From Chaotic And Incomplete Time Series Using Wavelet De-Noising And Spatiotemporal Kriging, Jared K. Nystrom, Raymond Hill, Andrew J. Geyer, Joseph J. Pignatiello Jr., Eric Chicken
Faculty Publications
Purpose: Present a method to impute missing data from a chaotic time series, in this case lightning prediction data, and then use that completed dataset to create lightning prediction forecasts.
Design/Methodology/Approach: Using the technique of spatiotemporal kriging to estimate data that is autocorrelated but in space and time. Using the estimated data in an imputation methodology completes a dataset used in lighting prediction.
Findings: The techniques provided prove robust to the chaotic nature of the data, and the resulting time series displays evidence of smoothing while also preserving the signal of interest for lightning prediction.
Abstract © Emerald Publishing …
Evaluating A Large Language Model’S Ability To Solve Programming Exercises From An Introductory Bioinformatics Course, Stephen R. Piccolo, Paul Denny, Andrew Luxton-Reilly, Samuel H. Payne, Perry G. Ridge
Evaluating A Large Language Model’S Ability To Solve Programming Exercises From An Introductory Bioinformatics Course, Stephen R. Piccolo, Paul Denny, Andrew Luxton-Reilly, Samuel H. Payne, Perry G. Ridge
Faculty Publications
Life scientists frequently write computer code when doing research. Computer programming can aid researchers in performing tasks that are not supported by existing tools. Programming can also help researchers to implement analytical logic in a way that documents their steps and thus enables others to repeat those steps. Many educational resources are available to teach computer programming, but this skill remains challenging for many researchers and students to master. Artificial-intelligence tools like OpenAI’s ChatGPT are able to interpret human-language requests to generate code. Accordingly, we evaluated the extent to which this technology might be used to perform programming tasks described …
Streamlining The Detection Of Human Thyroid Receptor Ligand Interactions With Xl1-Blue Cell-Free Protein Synthesis And Beta-Galactosidase Fusion Protein Biosensors, J. Porter Hunt, Tyler J. Free, Jackelyn Galiardi, Kevin M. Watt, David W. Wood, Bradley Charles Bundy
Streamlining The Detection Of Human Thyroid Receptor Ligand Interactions With Xl1-Blue Cell-Free Protein Synthesis And Beta-Galactosidase Fusion Protein Biosensors, J. Porter Hunt, Tyler J. Free, Jackelyn Galiardi, Kevin M. Watt, David W. Wood, Bradley Charles Bundy
Faculty Publications
Thyroid receptor signaling controls major physiological processes and disrupted signaling can cause severe disorders that negatively impact human life. Consequently, methods to detect thyroid receptor ligands are of great toxicologic and pharmacologic importance. Previously, we reported thyroid receptor ligand detection with cell-free protein synthesis of a chimeric fusion protein composed of the human thyroid receptor beta (hTRβ) receptor activator and a β-lactamase reporter. Here, we report a 60% reduction in sensing cost by reengineering the chimeric fusion protein biosensor to include a reporter system composed of either the full-length beta galactosidase (β-gal), the alpha fragment of β-gal (β-gal-α), or a …
Learning Experience Design As An Orienting Guide For Practice: Insights From Designing For Expertise, Jason K. Mcdonald, Tyler J. Westerberg
Learning Experience Design As An Orienting Guide For Practice: Insights From Designing For Expertise, Jason K. Mcdonald, Tyler J. Westerberg
Faculty Publications
In this paper we consider how learning experience design (LXD) improves designers’ capacities to influence learning. We do this by exploring what LXD offers the design of learning environments that help develop learners’ expertise. We discuss how LXD (a) attunes designers to different learning affordances than are emphasized in traditional ID; (b) challenges the universal applicability of common ID techniques; and (c) expands designers’ views of the outcomes for which they can design. These insights suggest that LXD is useful because it refocuses and reframes designers' work around flexible design approaches that are often deemphasized in traditional ID.