Digital Commons Network^™

Endothelial Dysfunction Promotes Age-Related Reorganization Of Collagen Fibers And Alters Aortic Biomechanics In Mice, Liya Du, Jeffrey Rodgers, Nazli Gharraee, Olivia Gary, Tarek Shazly, John F. Eberth, Susan M. Lessner

Faculty Publications

Endothelial dysfunction, defined as a reduction in the bioavailability of nitric oxide (NO), is a risk factor for the occurrence and progression of various vascular diseases. This study investigates the effect of endothelial dysfunction on age-related changes in aortic extracellular matrix (ECM) microstructure and the relationship between microstructural adaptation and the mechanical response. Here, we used groups of NOS3 knockout (KO), NOS3 heterozygotes (Het), and wild-type (WT) B6 mice (controls) to study changes in hemodynamic parameters, collagen fiber organization, and both active and passive aortic mechanics using biaxial pressure myography over a time course from 1.5 to 12 mo. Our …

Introduction: The Future Of Global Journalism—Relationships, Tools, And Power, Ruth Moon, Lea Hellmueller, Herman Wasserman

Faculty Publications

No abstract provided.

Unveiling The Nexus Between Digital Monitoring And Experiences Of Intimate Partner Violence In Romantic Relationships, Caley Hewitt, Fanny A. Ramirez, Anna Gjika

Faculty Publications

Using survey data from a sample of 378 women who live in the United States and self-identify as either Black or Latinx, this study explores predictors of women’s digital monitoring practices in intimate relationships in the context of intimate partner violence (IPV). We use literature about surveillance, monitoring, and IPV to frame our study. Our results show three significant instances that influence the odds of monitoring a romantic partner: (1) past experiences with digital abuse, (2) past experiences with offline psychological abuse, and (3) age, with younger women having increased odds of engaging in digital monitoring compared to older women. …

Review: Chasing The Stars: How Astronomers Of Observatory Hill Transformed Our Understanding Of The Universe, By James Lattis And Kelly Tyrrell, Thomas Hockey

Faculty Publications

No abstract provided.

Adipocyte-Derived Cchamide-1, Eiger, Growth-Blocking Peptide 3, And Unpaired 2 Regulate Drosophila Melanogaster Oogenesis, Chad Simmons, Isaiah H. Williams, Tancia W. Bradshaw, Alissa R. Armstrong

Faculty Publications

In addition to energy storage, adipose tissue communication to other organs plays a key role in regulating organismal physiology. While the link between adipose tissue dysfunction and pathophysiology, including diabetes, chronic inflammation, and infertility, is clear, the molecular mechanisms that underlie these associations have not been fully described. We use Drosophila melanogaster as a model to better understand how adipose tissue communicates to the ovary. In this study, we utilized D. melanogaster’s robust genetic toolkit to examine the role of five adipokines known to control larval growth during development, CCHamide-1, CCHamide-2, eiger, Growth-blocking peptide 3, and unpaired 2 in regulating …

Illustrations Of Benevolent And Hostile Heterosexism In Lgbtq+ People’S Lives, Jes L. Matsick, Lindsay Palmer, Flora Oswald, Mary Kruk, Kenneth Ye

Faculty Publications

In this study, we aimed to define heterosexism—a form of sexual stigma that accounts for interpersonal attitudes and institutionalized ideology—in a multi-dimensional way, centering on LGBTQ+ people’s experiences. We draw from an ambivalent theory of prejudice and focus on heterosexism, or an ideology that stigmatizes nonheterosexual behaviors, identities, relationships, and communities. We aimed to learn how LGBTQ+ people would narrate their experiences of heterosexism within a benevolent and hostile framing. In a qualitative online study, LGBTQ+ participants (N = 77; 49% White) reviewed definitions of and recalled encounters with benevolent and hostile heterosexism, providing examples of how heterosexism manifests …

On Large Language Models In National Security Applications, William N. Caballero, Phillip R. Jenkins

Faculty Publications

The overwhelming success of GPT-4 in early 2023 highlighted the transformative potential of large language models (LLMs) across various sectors, including national security. This article explores the implications of LLM integration within national security contexts, analyzing their potential to revolutionize information processing, decision-making, and operational efficiency. Whereas LLMs offer substantial benefits, such as automating tasks and enhancing data analysis, they also pose significant risks, including hallucinations, data privacy concerns, and vulnerability to adversarial attacks. Through their coupling with decision-theoretic principles and Bayesian reasoning, LLMs can significantly improve decision-making processes within national security organizations. Namely, LLMs can facilitate the transition from …

Family Risk Classes Predict Longitudinal Parent And Child Outcomes: Understanding The Implications Of Poverty-Related Adversity, Daniel K. Cooper, Benjamin L. Bayly, Brianna Tennie, Francesca Lupini, Martha E. Wadsworth

Faculty Publications

Experiencing poverty and associated risk factors can be detrimental to families’ mental health and well-being. However, it is unclear whether experiencing specific types or patterns of adversity leads to distinct outcomes. Guided by the Family Stress Model, the objective of this study was to (a) identify unique family risk classes based on exposure to various combinations of poverty-related adversity and (b) examine whether the family risk classes differed in their levels of parental coping strategies, couple relationship quality, parenting practices, and child behavior problems. The sample included 301 mother–father–child triads (602 adults and 301 children) with a combined income ≤ …

Exploring Emotion Classification Of Indonesian Tweets Using Large Scale Transfer Learning Via Indobert, Connor Shaw, Phillip M. Lacasse, Lance E. Champagne

Faculty Publications

Business, political, and other social structures create strong motivation to understand the attitudes, motivations, feelings, and emotions of a population of interest. Social media is a rich source of self-disclosed information by individuals from all walks of life about virtually every domain of the human experience, but the vast quantity of data is impossible to effectively analyze without advanced natural language processing algorithms. This research creates a transfer learning based emotion classification model for Indonesian language Twitter data. Transfer learning consists of two steps: pre-training and fine tuning. Three variations of Indonesian Bidirectional Encoder Representations from Transformers (IndoBERT) are tested …

Neurosymbolic Knowledge-Grounded Planning And Reasoning In Ai Systems, Amit Sheth, Vedant Khandelwal, Kaushik Roy, Vishal Pallagani, Megha Chakraborty

Faculty Publications

To build AI systems capable of decision-support assistance, such as AI-assisted healthcare, it is essential to develop user-centric decision-making processes that are robust, interpretable, and capable of effectively processing and acting on natural language interactions. Instruction-based prompting of large language models has demonstrated considerable success in supporting humans with information assistance tasks, including creative writing and content generation. However, recent studies reveal that language models exhibit limitations in performing complex reasoning and planning tasks, such as constructing compositional or hierarchical plans involving multiple reasoning steps. To address these challenges, we propose a neurosymbolic framework that integrates large language models with …

The Southern Miss Bower Academic Center: A Recent Academic Library-Athletics Partnership, Blake Denton

Faculty Publications

In 2019, A. Blake Denton published a literature review that identified and described 35 partnerships between academic libraries and athletics programs at higher education institutions in the United States, 20 of which were established for library marketing and development purposes. Recognizing that the literature documenting marketing and development partnerships was dated, he published a study in 2021 that provided updated, more comprehensive accounts for eight participating institutions and an analysis of the evolving nature of their relationships over time. This third article analyzes the partnership at the University of Southern Mississippi that resulted in the relocation of the athletics program’s …

Enhancing Mucus Flow And Clearance By Grafting Zwitterionic Hydrogel Films To Luminal Surfaces, Ryan Horne, Caleb Escudero, Morgan Ellerman, C. Allan Guymon, Marlan Hansen

Faculty Publications

Objective

To determine the effects of zwitterionic hydrogel films on mucus contact angles, flow, and stasis with respect to medical polymer surfaces, both flat and tubular.

Methods

A zwitterionic hydrogel thin film was photografted onto medical rubber surfaces and compared against non-zwitterionic hydrogel thin films and untreated surfaces to determine its impact on mucus contact angles, mucus flow on sheets and tubes, and mucus plugging.

Results

Zwitterionic and conventional hydrogel films significantly reduce the mucus contact angles and the tilt required to initiate mucus flow on sheets and in tubular systems. Preliminary experiments show that these films may also shorten …

Nucleoredoxin Regulates Wnt Signaling During Pituitary Stem Cell Differentiation, Michelle L. Brinkmeier, Leonard Y M Cheung, Sean P. O'Connell, Diana K. Gutierrez, Eve C. Rhoads, Sally A. Camper, Shannon W. Davis

Faculty Publications

Nucleoredoxin (Nxn) encodes a multi-functional enzyme with oxidoreductase activity that regulates many different signaling pathways and cellular processes in a redox-dependent manner. Rare NXN mutations are reported in individuals with recessive Robinow syndrome, which involves mesomelic skeletal dysplasia, short stature, craniofacial dysmorphisms, and incompletely penetrant heart and palate defects. Here we report that Nxn is expressed in the ventral diencephalon and developing pituitary gland, and that Nxn deficient mice have pituitary dysmorphology and craniofacial abnormalities that include defects in the skull base and cleft palate. Nxn mutant mice exhibit reduced WNT signaling and reduced differentiation of pituitary stem …

Pre-Exposure Prophylaxis Uptake Among Black/African American Men Who Have Sex With Other Men In Midwestern, United States: A Systematic Review, Oluwafemi Adeagbo, Oluwaseun Abdulganiyu Badru, Prince Addo, Amber Hawkins, Monique J. Brown Ph.D., Mph, Xiaoming Li, Rima Afifi

Faculty Publications

Introduction: Black/African American men who have sex with other men (BMSM) are disproportionately affected by HIV, experience significant disparities in HIV incidence, and face significant barriers to accessing HIV treatment and care services, including pre-exposure prophylaxis (PrEP). Despite evidence of individual and structural barriers to PrEP use in the Midwest, no review has synthesized this finding to have a holistic view of PrEP uptake and barriers. This review examines patterns of, barriers to, and facilitators of PrEP uptake among BMSM in the Midwest, United States (US).

Methods: Five databases (CINAHL Plus, PUBMED, PsycINFO, SCOPUS, and Web of Science) were searched …

From The Mountains To The Beach: Water Purification Ecosystem Services And Recreational Beach Use In Puerto Rico, Maya Corridore, Rebeca De Jesús Crespo, Mariam Valladares-Castellanos, Thomas Douthat

Faculty Publications

Recreational beach use is important for coastal economies and is influenced by water clarity, a trait that may be maintained by water purification ecosystem services (ESs). However, few studies have addressed these linkages. In this study, we ask the following questions: (1) Do watershed-scale water purification ecosystem services influence coastal water quality? (2) Does coastal water quality help explain beach visitation rates? To address these questions, we focused on Puerto Rico (PR), where coastal tourism has economic and cultural importance. We estimated water purification ESs using the Integrated Valuation of Ecosystem Services and Tradeoffs (InVEST), coastal water quality using long-term …

A 3d Superposition Approximation For Gamma Knife Dose Calculation, Payton H. Stone, Lam M. Lay, Raymi Ramirez, Daniel Neck, Connel Chu, Joyoni Dey, David Solis

Faculty Publications

Effective dose calculation is essential for optimizing Gamma Knife (GK) stereotactic radiosurgery (SRS) treatment plans. Modern GK systems allow independent sector activation, enabling complex dose distributions per shot. This study presents a dose approximation method designed to account for shot flexibility and generate 3D doses external to GammaPlan. A treatment plan was created with the TMR10 calculation for individual sector activations using a Radiosurgery Head Phantom. The resulting dose arrays established a basis set of sector-specific distributions, which were then referenced by shot parameters from the plan, allowing dose accumulation through superposition. This superposition approximation (SA) was compared to the …

Religious Nationalism: Narendra Modi’S 2019 Election Victory Speech, Nihar Sreepada

Faculty Publications

The ideology of nationalism is permeating and ascending across societies, eventually manifesting materially in several nations across the world. In this essay, I analyze the religious manifestation of nationalism within the context of India’s Hindu nationalism. I argue that Modi, in his 2019 election victory speech, constructs a grand narrative of Hindu nationalistic unification by positioning himself as a Hindu sanyasi (ascetic) and by alluding to Hindu mythologies. First, I present the historical context of India’s Hindu nationalism (Hindutva). Second, I explicate the formation of an ideological discourse through Kenneth Burke’s focus on identification and the constitutive rhetoric of calling …

Rural–Urban Differences In Substance Use During Pregnancy, Emma Kathryn Boswell, Olivia M. Hinds, Cassie Odahowski Phd, Mph, Elizabeth L. Crouch, Peiyin Hung Ph.D, Christina M. Andrews Ph.D.

Faculty Publications

Purpose: Drug overdoses are now a leading cause of pregnancy-related deaths in the United States. Despite evidence of rural–urban disparities in substance use, there has not yet been a nationally representative examination of rural–urban differences in perinatal substance use. This study provides a comprehensive examination of rural–urban disparities in perinatal substance use. Methods: This study uses cross-sectional data to examine 3499 pregnant women from the 2015–2019 National Survey on Drug Use and Health (NSDUH). Rural (nonmetro)–urban (metro) differences in past-month tobacco use, alcohol use, binge drinking, illicit drug use, and marijuana use were examined using Rao–Scott chi-square tests and multivariable …

Is Bullying Associated With Health Risk And Quality Of Life Behaviors In Adolescents?, Ana Beatriz Pacífico, Eliane Denise Araújo Bacil, Thiago Silva Piola, Michael Pereira Da Silva, Fabio Fontana, Jhonatan Gritten Campos, Ademar Avelar, Wagner De Campos

Faculty Publications

This study assessed the practice of bullying, health risk behavior and quality of life in adolescent boys and girls from the city of Maringá, Paraná. A representative sample of 1,020 adolescents participated in the study to assess the association between bullying, health-risk behavior, and quality of life factors through self-reported questionnaires. Odds ratios with 95% confidence intervals (95%CI) were obtained using both crude and adjusted binary and ordinal logistic regression, with a significance level of p< 0.05. Male bullying perpetrators were 2.2 (95%CI=1.4-3.4) and 2.0 (95%CI=1.2-3.2) times more likely to consume alcohol and engage in physical activity compared to non-bullying males. Female bullying perpetrators were 2.1 (95%CI=1.3-3.5), 3.6 (95%CI=1.3-10.1), 1.8 (95%CI=1.1-2.9), and 2.7 (95%CI=1.1-6.3) times more likely to smoke, use illicit drugs, be addicted to smartphones, and have poorer sleep quality. These girls also had a 60% higher chance of having a worse perception of quality of life, respectively, compared to non-bullying females. The conclusion drawn is that bullying may be associated with health risk behaviors for both boys and girls.

Geographic Disparities In Unpaid Caregiving, Emma Kathryn Boswell, Monique J. Brown Ph.D., Mph, Lorie Donelle Phd, Rn, Fcan, Nicholas Yell, Taryn Farrell, Peiyin Hung Ph.D., Elizabeth Crouch Ph.D.

Faculty Publications

Purpose: An updated, nationally representative examination of rural–urban differences in the experiences, health, and well-being of caregivers is needed; previous research on this topic uses older data or has limited generalizability. This study examines rural–urban differences in the characteristics, experiences, and health of caregivers. Methods: The 2021–2022 Behavioral Risk Factor Surveillance System (n = 44,274 unpaid caregivers) was used, with rurality defined according to the 2013 National Center for Health Statistics (NCHS) Urban-Rural Classification Scheme. Chi-square tests compared rural–urban differences in these caregivers’ characteristics, including demographic factors, caregiving intensity (e.g., weekly hours spent caregiving, reason for caregiving, past-month ADL/IADL assistance), …

Race, The Academy, And The Constitution Of The War On Drugs, Bennett Capers, Jeffrey Bellin

Faculty Publications

The war on drugs is widely viewed as a policy failure. Despite massive government intrusions on personal liberty, drug addiction, overdoses, and drug-related violence have only increased since the war was declared in 1971. David Pozen’s new book, The Constitution of the War on Drugs, reveals a constitutional failure as well. Pozen chronicles a host of constitutional arguments that American litigants deployed to protect a “right” to use drugs with surprising, if fleeting, success. Pozen asks what might have been, exploring why the courts backtracked and effectively removed the Constitution as a meaningful obstacle to drug prohibitions.

This Review …

Trends In Scholarly Communication, Eleta Exline

Faculty Publications

Slides from a presentation on scholarly communication developments to the UNH Retired Faculty Association.

Modulating The Aqueous Micellar Reorganization Of Sequence-Defined Ionic Peptoid Block Copolymers By Ionizable Monomer Position And Solution Ph, Bailee N. Barrett, Pedram Azizihariri, Vijay T. John, Donghui Zhang

Faculty Publications

The micellar aggregation of singly charged sequence-defined ionic peptoid block copolymers can be finely tuned by adjusting the position of the ionizable monomer along the chain and varying the solution pH. The pH-induced structural reorganization of these micelles was found to depend on the position of the ionizable monomer along the chain, influencing the balance of the hydrophobic interactions, excluded volume effect, and electrostatic forces (i.e., charge repulsion, solvation of the ionic monomers, counterion association) that govern the micellar structure. As the solution pH increases, positioning the ionizable monomer closer to the junction of the hydrophobic and hydrophilic blocks causes …

Materiality In The Csr-Investor Reaction Relationship: A Replication And Extension Of Flammer (2013), Steven D. Kofford, Myles Melancon, Ben W. Lewis

Faculty Publications

We replicate and extend Flammer’s (2013) event study of investor reaction to environmental corporate social responsibility (CSR). Flammer found that investors reacted positively to eco-friendly events and negatively to eco-harmful events from 1980-2009 and that reaction to positive events decreased while reaction to negative events increased over time. We find similar results for Flamer’s original sample and an expanded sample including the same type of firms (U.S.-listed public firms) from 1980-2019. We then extend Flammer’s results by examining how materiality affects investor reaction over time. We find that investors only react to material events and that positive reaction to material …

Million-Dollar Mysteries: Recent Complex Patent Cases Lost To Rule 36, Dennis D. Crouch

Faculty Publications

This article examines the Federal Circuit's continued use of Rule 36 summary affirmances to dispose of complex patent cases without written opinions. Through analysis of eight recent Rule 36 cases decided in early 2025, the author demonstrates that sophisticated legal issues involving millions of dollars are being summarily affirmed despite presenting novel and important questions of patent law. The cases discussed involve design patent evidentiary standards, jury trial rights for hybrid legal-equitable claims, analogous art determinations, claim construction, written description requirements, and PTAB procedural issues. The author argues that while the court may be avoiding difficult cases with complex factual …

Streamlined Production, Protection, And Purification Of Enzyme Biocatalysts Using Virus-Like Particles And A Cell-Free Protein Synthesis System, Seung O. Yang, Joseph P. Talley, Gregory H. Nielsen, Kristen M. Wilding, Bradley Charles Bundy

Faculty Publications

Enzymes play an essential role in many different industries; however, their operating conditions are limited due to the loss of enzyme activity in the presence of proteases and at temperatures significantly above physiological conditions. One way to improve the stability of these enzymes against high temperatures and proteases is to encapsulate them in protective shells or virus-like particles. This work presents a streamlined, three-step, cell-free protein synthesis (CFPS) procedure that enables rapid in vitro enzyme production, targeted encapsulation in protective virus-like particles (VLPs), and facile purification using a 6× His-tag fused to the VLP coat protein. This process is performed …

What's The Matter With Batna? It's Misleading And Doesn't Help Advance Parties' Important Interests, John Lande

Faculty Publications

Many dispute resolution experts misunderstand the concept of BATNA (the best alternative to a negotiated agreement), believing that it is the most favorable possible outcome if the parties don’t settle. In fact, BATNA isn’t an expected result. It’s a course of action, not the value resulting from the course of action.

Attorneys often make unrealistic predictions of court outcomes because of inherent uncertainty and cognitive biases. Moreover, parties have many intangible interests that aren’t included in estimates of BATNA values.

This article offers suggestions for attorneys and mediators to advance clients’ interests by better understanding and valuing non-settlement outcomes.

Threat Perceptions, Defensive Behaviors, And The Perceived Suicide Prevention Value Of Specific Firearm Storage Practices, Michael D. Anestis, Craig J. Bryan, Anna Belle O. Bryan, Daniel W. Capron

Faculty Publications

Introduction: Secure firearm storage has been proposed as a suicide prevention method within the military; however, secure storage practices are uncommon. Service members may perceive limited value in secure storage as a suicide prevention tool and threat-related factors may influence such perceptions. Method: A nationally representative sample of firearm-owning military service members (n = 719) was recruited between December 3, 2021 and January 4, 2022 to complete a self-report survey by Ipsos using their KnowledgePanel calibration approach to optimize representativeness. Results: Threat sensitivity was associated with less perceived suicide prevention value across all within-home storage practices as well as out-of-home …

Butterfly Species Vary In Sex-Specific Sodium Accumulation From Larval Diets, Luis Y. Santiago-Rosario, Alexander M. Shephard, Emilie Snell-Rood, Achim D. Herrmann, Kyle E. Harms

Faculty Publications

Sodium is essential for animals, and its heterogeneous distribution can cause a range of phenomena, from sodium-seeking behaviours to impacting their performance. Although sodium content in soils and plants is relatively well documented, data for higher trophic levels are limited. Knowledge of the variation in sodium in lower trophic levels could have implications for understanding the behaviour and physiology of species at higher levels. We investigated the variation in tissue sodium concentration between males and females of four butterfly species. Puddling behaviour of Lepidoptera suggests sodium needs of males are generally greater than females, thus, we predicted males would accumulate …

Counseling Students’ Perceptions Of Support During The Covid-19 Crisis: A Qualitative Study., Breahannah Hilarie, Galaxina G. Wright, Lea H., Laurie O. Campbell

Faculty Publications

The COVID-19 pandemic changed the counseling programs in clinical instruction, mentorship, and student’s perception of the university. The qualitative data presented in this paper identifies eight counseling students’ beliefs of support during their time in counseling program during the COVID-19 pandemic. Data was obtained through semi-structured interviews. An interpretive phenomenological analysis resulted in four themes: including higher education response, personal resources, emotions in crisis, and transitions in crisis.