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Getting Back On Track: Why Some Young Men Stay In The Church And Not Others, S. Joseph Kidder, Natalie Dorland Apr 2021

Getting Back On Track: Why Some Young Men Stay In The Church And Not Others, S. Joseph Kidder, Natalie Dorland

Faculty Publications

No abstract provided.


Book Review: Social Media And Democracy: The State Of The Field And Prospects For Reform, Cynthia W. Bassett Apr 2021

Book Review: Social Media And Democracy: The State Of The Field And Prospects For Reform, Cynthia W. Bassett

Faculty Publications

Social Media and Democracy illuminates the empirical social science research done to date to tease apart the effects social media has had on representative democracies. It is a collection of essays by academic social scientists researching the intersection of social media and democracy from a variety of angles.


Effect Of Serving Plate Types And Color Cues On Liking And Purchase Intent Of Cheese-Flavored Tortilla Chips, Cristhiam Gurdian, Damir Torrico, Bin Li, Witoon Prinyawiwatkul Apr 2021

Effect Of Serving Plate Types And Color Cues On Liking And Purchase Intent Of Cheese-Flavored Tortilla Chips, Cristhiam Gurdian, Damir Torrico, Bin Li, Witoon Prinyawiwatkul

Faculty Publications

No abstract provided.


Stakeholder’S Risk Perceptions Ofwild Pigs: Is There A Gender Difference?, Maria Bampasidou, Michael D. Kaller, Shaun M. Tanger Apr 2021

Stakeholder’S Risk Perceptions Ofwild Pigs: Is There A Gender Difference?, Maria Bampasidou, Michael D. Kaller, Shaun M. Tanger

Faculty Publications

Substantial literature indicates that genders differ in terms of risk perception and values regarding wildlife management. Lack of equal stakeholder representation is also documented, which can also impact the effectiveness of human-wildlife conflict resolution interventions and education and outreach efforts. This paper investigates gender differences in perceptions about risks and potential adverse impacts on production, health, environment, safety, and population management posed by wild pigs. A survey was used to collect data from a random sample of adult residents (N = 1221) in Louisiana. We analyzed responses from 226 female and 832 male producers. We observed differences in how these …


A Generalized Approach For Sperm Cryopreservation In The Genus Pomoxis: Sperm Cryopreservation And Fertilization Efficiency Of Black-Stripe Black Crappie, Pomoxis Nigromaculatus, Christian A. Shirley, Michael E. Colvin, Terrence R. Tiersch, Peter J. Allen Apr 2021

A Generalized Approach For Sperm Cryopreservation In The Genus Pomoxis: Sperm Cryopreservation And Fertilization Efficiency Of Black-Stripe Black Crappie, Pomoxis Nigromaculatus, Christian A. Shirley, Michael E. Colvin, Terrence R. Tiersch, Peter J. Allen

Faculty Publications

Approaches for white crappie, Pomoxis annularis sperm cryopreservation have led to interest in applying similar methods to black-stripe black crappie, Pomoxis nigromaculatus. Their rarity in wild populations makes them a preferred phenotype for hatchery use. Sperm cryopreservation procedures were compared between black-stripe black crappie and white crappie for sperm motility and egg fertilization rate. There was no difference in black-stripe black crappie sperm motility after thawing between 5% dimethyl sulfoxide (DMSO, 45% motility) and 10% methanol (50% motility). However, fertilization rates were higher (p <.001) for sperm cryoprotected with 5% DMSO (38 ± 8%) than 10% methanol (22 ± 7%). Hatchery use requires sperm-to-egg ratios and fertilizing potential of single doses (i.e., 0.5 ml straw). Using black-stripe black crappie sperm (2.5 × 108 sperm/ml; 5% DMSO), the highest fertilization (27%) was found using single straws with 785 eggs (0.25 ml); total sperm:egg ratio: 159,000:1; motile sperm:egg ratio: 71,700:1. Therefore, sperm of two Pomoxis species could be cryopreserved using 350 mOsmol/kg Hanks' balanced salt solution as an extender, 5% DMSO as a cryoprotectant, cooling at 40°C/min, and thawing for 8 s at 40°C to maintain sperm motility and fertility. Basic protocols can be generalized within a genus if variables such as sperm concentration, process timing, and sample volumes are controlled.


Hydrothermal Synthesis And Structural Investigation Of A Crystalline Uranyl Borosilicate, Kristen A. Pace, Vladislav V. Klepov, Mark D. Smith, Travis Williams, Gregory Morrison, Jochen A. Lauterbach, Scott T. Misture, Hans Conrad Zur Loye Apr 2021

Hydrothermal Synthesis And Structural Investigation Of A Crystalline Uranyl Borosilicate, Kristen A. Pace, Vladislav V. Klepov, Mark D. Smith, Travis Williams, Gregory Morrison, Jochen A. Lauterbach, Scott T. Misture, Hans Conrad Zur Loye

Faculty Publications

The relevance of multidimensional and porous crystalline materials to nuclear waste reme-diation and storage applications has motivated exploratory research focused on materials discovery of compounds, such as actinide mixed-oxoanion phases, which exhibit rich structural chemistry. The novel phase K1.8 Na1.2 [(UO2)BSi4 O12 ] has been synthesized using hydrothermal methods, rep-resenting the first example of a uranyl borosilicate. The three-dimensional structure crystallizes in the orthorhombic space group Cmce with lattice parameters a = 15.5471(19) Å, b = 14.3403(17) Å, c = 11.7315(15) Å, and V = 2615.5(6) Å3, and is composed of UO6 octahedra linked by [BSi4 O12 ]5− chains to …


Genes Related To Redox And Cell Curvature Facilitate Interactions Between Caulobacter Strains And Arabidopsis, Louis Berrios, Bert Ely Apr 2021

Genes Related To Redox And Cell Curvature Facilitate Interactions Between Caulobacter Strains And Arabidopsis, Louis Berrios, Bert Ely

Faculty Publications

Bacteria play an integral role in shaping plant growth and development. However, the genetic factors that facilitate plant-bacteria interactions remain largely unknown. Here, we demonstrated the importance of two bacterial genetic factors that facilitate the interactions between plant-growth-promoting (PGP) bacteria in the genus Caulobacter and the host plant Arabidopsis. Using homologous recombination, we disrupted the cytochrome ubiquinol oxidase (cyo) operon in both C. vibrioides CB13 and C. segnis TK0059 by knocking out the expression of cyoB (critical subunit of the cyo operon) and showed that the mutant strains were unable to enhance the growth of Arabidopsis. In addition, disruption of …


Fishing For Food: Values And Benefits Associated With Coastal Infrastructure, Cassandra M. Nieman, Alexie N. Rudman, Margaret L. Chory, Grant D. Murray, Luke Fairbanks, Lisa M. Campbell Apr 2021

Fishing For Food: Values And Benefits Associated With Coastal Infrastructure, Cassandra M. Nieman, Alexie N. Rudman, Margaret L. Chory, Grant D. Murray, Luke Fairbanks, Lisa M. Campbell

Faculty Publications

While there is substantial literature about the socio-cultural characteristics and values associated with recreational and commercial fisheries in the U.S., studies directed at those who ‘fish for food’—those who depend on consuming their catch to various degrees—are relatively sparse. Using qualitative data collected through 80 semi-structured interviews with fishers in the summer and fall of 2018 in Carteret County, North Carolina, this study aims to better understand the group of recreational fishers who consume their catch by describing social and cultural dimensions and values associated with fishing for food, examining the role of infrastructure in facilitating access to benefits associated …


Heterogeneous Co2And Ch4Content Of Glacial Meltwater From The Greenland Ice Sheet And Implications For Subglacial Carbon Processes, Andrea J. Pain, Jonathan B. Martin, Ellen E. Martin, Åsa K. Rennermalm, Shaily Rahman Apr 2021

Heterogeneous Co2And Ch4Content Of Glacial Meltwater From The Greenland Ice Sheet And Implications For Subglacial Carbon Processes, Andrea J. Pain, Jonathan B. Martin, Ellen E. Martin, Åsa K. Rennermalm, Shaily Rahman

Faculty Publications

Accelerated melting of the Greenland Ice Sheet has increased freshwater delivery to the Arctic Ocean and amplified the need to understand the impact of Greenland Ice Sheet meltwater on Arctic greenhouse gas budgets. We evaluate subglacial discharge from the Greenland Ice Sheet for carbon dioxide (CO2) and methane (CH4) concentrations and δ13C values and use geochemical models to evaluate subglacial CH4 and CO2 sources and sinks. We compare discharge from southwest (a sub-catchment of the Isunnguata Glacier, sub-Isunnguata, and the Russell Glacier) and southern Greenland (Kiattut Sermiat). Meltwater CH4 concentrations vary …


Temperature Dependence Of Density And Viscosity Of Biobutanol-Gasoline Blends, Daniel Trost, Adam Polcar, Dorin Boldor, Divine Bup Nde, Artur Wolak, Vojtĕch Kumbár Apr 2021

Temperature Dependence Of Density And Viscosity Of Biobutanol-Gasoline Blends, Daniel Trost, Adam Polcar, Dorin Boldor, Divine Bup Nde, Artur Wolak, Vojtĕch Kumbár

Faculty Publications

Butanol seems to be an eligible fuel for compensating for the increasing fuel consumption. Biobutanol could be produced from local sources in the place of use. Its properties show similar results to gasoline, so biobutanol could be added as a biocomponent into fuels. Important properties, in the case of blending biobutanol into gasoline, are its fluid properties and their dependence on the temperature. Therefore, in this paper, the volumetric mass density and viscosity of the selected ratios between biobutanol and gasoline (0, 5, 10, 85, 100 vol.%) were tested over the temperature range from -10 °C up to 40 °C. …


Microwave-Assisted Lignin Liquefaction In Hydrazine And Ethylene Glycol: Reaction Pathways Via Response Surface Methodology, Divine B. Nde, Mohamad Barekati-Goudarzi, Pranjali D. Muley, Lavrent Khachatryan, Dorin Boldor Apr 2021

Microwave-Assisted Lignin Liquefaction In Hydrazine And Ethylene Glycol: Reaction Pathways Via Response Surface Methodology, Divine B. Nde, Mohamad Barekati-Goudarzi, Pranjali D. Muley, Lavrent Khachatryan, Dorin Boldor

Faculty Publications

Microwave assisted liquefaction (MAL) of alkali lignin in ethylene glycol (EG) in the presence of hydrazine was carried out using response surface methodology. Dielectric properties of mixtures of lignin/EG at different hydrazine concentrations were determined to enhance the understanding of the MAL process. MAL parameters were hydrazine concentration (1–3%), temperature (100-180 °C), time (5-45 min) with the maximum microwave heating power limited to 750 W. Lignin/EG ratio was fixed at 1 g:10 ml. Dielectric properties were significantly influenced by hydrazine concentration and temperature. Major products from the liquefaction process (as % of peak areas) were grouped into guaiacol and derivatives …


Genes Related To Redox And Cell Curvature Facilitate Interactions Between Caulobacter Strains And Arabidopsis, Louis Berrios, Bert Ely Apr 2021

Genes Related To Redox And Cell Curvature Facilitate Interactions Between Caulobacter Strains And Arabidopsis, Louis Berrios, Bert Ely

Faculty Publications

Bacteria play an integral role in shaping plant growth and development. However, the genetic factors that facilitate plant-bacteria interactions remain largely unknown. Here, we demonstrated the importance of two bacterial genetic factors that facilitate the interactions between plant-growth-promoting (PGP) bacteria in the genus Caulobacter and the host plant Arabidopsis. Using homologous recombination, we disrupted the cytochrome ubiquinol oxidase (cyo) operon in both C. vibrioides CB13 and C. segnis TK0059 by knocking out the expression of cyoB (critical subunit of the cyo operon) and showed that the mutant strains were unable to enhance the growth of …


Twisted Spatiotemporal Optical Vortex Random Fields, Milo W. Hyde Iv Apr 2021

Twisted Spatiotemporal Optical Vortex Random Fields, Milo W. Hyde Iv

Faculty Publications

We present twisted spatiotemporal optical vortex (STOV) beams, which are partially coherent light sources that possess a coherent optical vortex and a random twist coupling their space and time dimensions. These beams have controllable partial coherence and transverse orbital angular momentum (OAM), which distinguishes them from the more common spatial vortex and twisted beams (known to carry longitudinal OAM) in the literature and should ultimately make them useful in applications such as optical communications and optical tweezing. We present the mathematical analysis of twisted STOV beams, deriving the mutual coherence function and linear and angular momentum densities. We simulate the …


Discursive Power And Resistance In The Information Worlds Maps Of Lgbtqia+ Community Leaders, Vanessa Kitzie, Travis L. Wagner, Alexander N. Vera Apr 2021

Discursive Power And Resistance In The Information Worlds Maps Of Lgbtqia+ Community Leaders, Vanessa Kitzie, Travis L. Wagner, Alexander N. Vera

Faculty Publications

Purpose: This qualitative study explores how discursive power shapes South Carolina LGBTQIA+ communities' health information practices and how participants resist this power. Design/methodology/approach: Twenty-eight LGBTQIA+ community leaders from South Carolina engaged in semi-structured interviews and information worlds mapping – a participatory arts-based elicitation technique – to capture the context underlying how they and their communities create, seek, use, and share health information. We focus on the information worlds maps for this paper, employing situational analysis – a discourse analytic method for visual data – to analyze them. Findings: Six themes emerged describing how discursive power operates both within and outside …


Tax Administration And Racial Justice: The Illegal Denial Of Tax Based Pandemic Relief To The Nation's Incarcerated, Leslie Book Apr 2021

Tax Administration And Racial Justice: The Illegal Denial Of Tax Based Pandemic Relief To The Nation's Incarcerated, Leslie Book

Faculty Publications

No abstract provided.


“When They Say Weed Causes Depression, But It’S Your Fav Antidepressant”: Knowledge-Aware Attention Framework For Relationship Extraction, Shweta Yadav, Usha Lokala, Raminta Daniulaityte, Krishnaprasad Thirunarayan, Francois Lamy, Amit P. Sheth Mar 2021

“When They Say Weed Causes Depression, But It’S Your Fav Antidepressant”: Knowledge-Aware Attention Framework For Relationship Extraction, Shweta Yadav, Usha Lokala, Raminta Daniulaityte, Krishnaprasad Thirunarayan, Francois Lamy, Amit P. Sheth

Faculty Publications

With the increasing legalization of medical and recreational use of cannabis, more research is needed to understand the association between depression and consumer behavior related to cannabis consumption. Big social media data has potential to provide deeper insights about these associations to public health analysts. In this interdisciplinary study, we demonstrate the value of incorporating domain-specific knowledge in the learning process to identify the relationships between cannabis use and depression. We develop an end-to-end knowledge infused deep learning framework (Gated-K-BERT) that leverages the pre-trained BERT language representation model and domain-specific declarative knowledge source (Drug Abuse Ontology) to jointly extract entities …


Characterization, Bio-Uptake And Toxicity Of Polymer-Coated Silver Nanoparticles And Their Interaction With Human Peripheral Blood Mononuclear Cells, Sahar Pourhoseini, Reilly T. Enos, Angela E. Murphy, Bo Cai Ph.D., Jamie Lead Mar 2021

Characterization, Bio-Uptake And Toxicity Of Polymer-Coated Silver Nanoparticles And Their Interaction With Human Peripheral Blood Mononuclear Cells, Sahar Pourhoseini, Reilly T. Enos, Angela E. Murphy, Bo Cai Ph.D., Jamie Lead

Faculty Publications

Silver nanoparticles (AgNPs) are widely used in medical applications due to their antibacterial and antiviral properties. Despite the extensive study of AgNPs, their toxicity and their effect on human health is poorly understood, as a result of issues such as poor control of NP properties and lack of proper characterization. The aim of this study was to investigate the combined characterization, bio-uptake, and toxicity of well-characterized polyvinylpyrrolidone (PVP)-coated AgNPs in exposure media during exposure time using primary human cells (peripheral blood mononuclear cells (PBMCs)). AgNPs were synthesized in-house and characterized using a multimethod approach. Results indicated the transformation of NPs …


Living Our Mission Together, Andrea Luxton Mar 2021

Living Our Mission Together, Andrea Luxton

Faculty Publications

No abstract provided.


Pathways To Adventist Education, Ariel Solis, Kimberly Pichot, Kim Ferreira Mar 2021

Pathways To Adventist Education, Ariel Solis, Kimberly Pichot, Kim Ferreira

Faculty Publications

No abstract provided.


The 2022-2023 Global Church Member Survey: Developing The Questionnaire, Karl G. D. Bailey, Duane C. Mcbride, Shannon Trecartin Mar 2021

The 2022-2023 Global Church Member Survey: Developing The Questionnaire, Karl G. D. Bailey, Duane C. Mcbride, Shannon Trecartin

Faculty Publications

No abstract provided.


Mining Open Government Data For Business Intelligence Using Data Visualization: A Two-Industry Case Study, Anne Gottfried, Caroline Hartmann, Donald Yates Mar 2021

Mining Open Government Data For Business Intelligence Using Data Visualization: A Two-Industry Case Study, Anne Gottfried, Caroline Hartmann, Donald Yates

Faculty Publications

The business intelligence (BI) market has grown at a tremendous rate in the past decade due to technological advancements, big data and the availability of open source content. Despite this growth, the use of open government data (OGD) as a source of information is very limited among the private sector due to a lack of knowledge as to its benefits. Scant evidence on the use of OGD by private organizations suggests that it can lead to the creation of innovative ideas as well as assist in making better informed decisions. Given the benefits but lack of use of OGD to …


Public Opinion Regarding Government Response To Covid-19: Case Study Of A Large Commercial City In Nigeria, Ismaeel Yunusa Ph.D., Sorochi Iloanusi, Osaro Mgbere, Nchebe-Jah Raymond Iloanusi, Anthony Idowu Ajayi, Ekere James Essien Mar 2021

Public Opinion Regarding Government Response To Covid-19: Case Study Of A Large Commercial City In Nigeria, Ismaeel Yunusa Ph.D., Sorochi Iloanusi, Osaro Mgbere, Nchebe-Jah Raymond Iloanusi, Anthony Idowu Ajayi, Ekere James Essien

Faculty Publications

Introduction: government measures to contain the COVID-19 pandemic cannot be effective without widespread compliance by the public. A greater understanding of citizens' perceptions of these measures can help government agencies adapt their strategies to boost compliance. We examined citizens' perceptions of government's measures to contain the COVID-19 pandemic and its implications on compliance using data from Onitsha city, Anambra State Nigeria.

Methods: data was obtained through in-person interviews of 140 consenting adults in March 2020. Descriptive and inferential statistics were used to summarize the data.

Results: most participants (84.7%) doubted government's ability to manage the COVID-19 outbreak, raising concerns about …


Coastlines, Coastal Cities, And Climate Change: A Perspective On Urgent Research Needs In The United States, Paul A. Sandifer, Geoffrey I. Scott Ph.D. Mar 2021

Coastlines, Coastal Cities, And Climate Change: A Perspective On Urgent Research Needs In The United States, Paul A. Sandifer, Geoffrey I. Scott Ph.D.

Faculty Publications

This paper builds upon Friedman et al. (2020) and other reviews and statements but provides an explicit focus on research needed to improve the resilience and survivability of coastal communities as they face existential threats from climate change. It does not attempt a prescriptive analysis of potential research emphases, but instead recommends some key research areas that we believe will help provide a solid foundation for community adaptation. Our perspective is based on our experiences over a combined nearly 95 years of work in research, management, and policy, much of it related to coastal environments and their communities, rather than …


Hearing Loss Prevalence And Years Lived With Disability, 1990–2019: Findings From The Global Burden Of Disease Study 2019, Ismaeel Yunusa, Lydia M. Haile, Kaloyan Kamenov, Paul Svitil Briant, Aislyn U. Orji, Jaimie D. Steinmetz, Et. Al. Mar 2021

Hearing Loss Prevalence And Years Lived With Disability, 1990–2019: Findings From The Global Burden Of Disease Study 2019, Ismaeel Yunusa, Lydia M. Haile, Kaloyan Kamenov, Paul Svitil Briant, Aislyn U. Orji, Jaimie D. Steinmetz, Et. Al.

Faculty Publications

Background

Hearing loss affects access to spoken language, which can affect cognition and development, and can negatively affect social wellbeing. We present updated estimates from the Global Burden of Disease (GBD) study on the prevalence of hearing loss in 2019, as well as the condition's associated disability.

Methods

We did systematic reviews of population-representative surveys on hearing loss prevalence from 1990 to 2019. We fitted nested meta-regression models for severity-specific prevalence, accounting for hearing aid coverage, cause, and the presence of tinnitus. We also forecasted the prevalence of hearing loss until 2050.

Findings

An estimated 1.57 billion (95% uncertainty interval …


Examination Of Eating Disorder Risk Among University Marching Band Artists, Nancy A. Uriegas, Dawn M. Emerson, Allison B. Smith, Melani R. Kelly, Toni M. Torres-Mcgehee Mar 2021

Examination Of Eating Disorder Risk Among University Marching Band Artists, Nancy A. Uriegas, Dawn M. Emerson, Allison B. Smith, Melani R. Kelly, Toni M. Torres-Mcgehee

Faculty Publications

BACKGROUND: Marching band artists are a physically active population, composed of approximately 27,000 people in the United States. University marching band artists face many of the same physically active demands and mental stressors as student athletes, potentially predisposing them to injury, illness, and risk for eating disorders (EDs). The purpose of this study was to examine ED risk across sex in university marching band artists, and to determine the type of risk based on the Eating Disorder Inventory-3 (EDI-3) and Eating Disorder Inventory-3 Symptom Check List (EDI-3 SC). A secondary aim examined marching band artists and pathogenic weight control behavior …


The Connecticut Second Chance​ ​Pardon​ ​Gap, Colleen Chien, Hithesh Bathala, Prajakta Pingale, Evan Hastings, Adam Osmond Mar 2021

The Connecticut Second Chance​ ​Pardon​ ​Gap, Colleen Chien, Hithesh Bathala, Prajakta Pingale, Evan Hastings, Adam Osmond

Faculty Publications

Connecticut Law Chapter 961a Section 54-142a, Chapter 960a Sections 54-76o and 54-130a allows individuals whose criminal records meet certain conditions to apply for pardons of their past criminal convictions. Proposed Bill SB 403,2 Connecticut’s “Clean Slate” Act, likewise would provide for automatic erasure of the records of a subset of individuals who can apply for pardons. Ascertaining, then applying existing pardons law and proposed “Clean Slate” law to a sample of 309,827 criminal histories of individuals with Connecticut convictions records, and then extrapolating to the estimated population of 450K individuals in the state with convictions,3 we estimate the share and …


The More Things Change, The More They Stay The Same: The Queensland Police Service As A Model For Sustainable Policing Reform, Geoffrey P. Alpert, Kyle Mclean Mar 2021

The More Things Change, The More They Stay The Same: The Queensland Police Service As A Model For Sustainable Policing Reform, Geoffrey P. Alpert, Kyle Mclean

Faculty Publications

Police departments are consistently challenged to serve their communities by reducing misconduct and being held accountable. In the United States, policing reform is best described as déjà vu or Groundhog Day, with high-profile groups organising every few years to list the same recommendations for improving the police. Additionally, reform suggestions are too often countered by the comment, “we have always done it this way.” By stark contrast, through the Fitzgerald Inquiry and the work of scholars such as David Bayley, the Queensland Police Service stands as a model for creating sustainable change in policing. In this paper, we compare the …


The Epigenetics Of Gametes And Early Embryos And Potential Long-Range Consequences In Livestock Species—Filling In The Picture With Epigenomic Analyses, Linkai Zhu, Sadie L. Marjani, Zongliang Jiang Mar 2021

The Epigenetics Of Gametes And Early Embryos And Potential Long-Range Consequences In Livestock Species—Filling In The Picture With Epigenomic Analyses, Linkai Zhu, Sadie L. Marjani, Zongliang Jiang

Faculty Publications

The epigenome is dynamic and forged by epigenetic mechanisms, such as DNA methylation, histone modifications, chromatin remodeling, and non-coding RNA species. Increasing lines of evidence support the concept that certain acquired traits are derived from environmental exposure during early embryonic and fetal development, i.e., fetal programming, and can even be “memorized” in the germline as epigenetic information and transmitted to future generations. Advances in technology are now driving the global profiling and precise editing of germline and embryonic epigenomes, thereby improving our understanding of epigenetic regulation and inheritance. These achievements open new avenues for the development of technologies or potential …


A Single-Well Gas-Assisted Gravity Drainage Enhanced Oil Recovery Process For U.S. Deepwater Gulf Of Mexico Operations, Bikash D. Saikia, Dandina N. Rao Mar 2021

A Single-Well Gas-Assisted Gravity Drainage Enhanced Oil Recovery Process For U.S. Deepwater Gulf Of Mexico Operations, Bikash D. Saikia, Dandina N. Rao

Faculty Publications

The U.S. Deepwater Gulf of Mexico (DGOM) area that has some of the most prolific oil reservoirs is still awaiting the development of a viable enhanced oil recovery (EOR) process. Without it, DGOM will remain severely untapped. Exorbitant well costs, in excess of $200 million, preclude having extensive injection patterns, commonly used in EOR design frameworks. Aside from injection patterns, even operationally waterflooding has met with significant challenges because of injectivity issues in these over pressurized turbidities. The gas-assisted gravity drainage (GAGD) EOR process, that holds promise for deepwater environments because of lesser injectivity issues, among others, has been adapted …


Discovery Of Clioquinol And Analogues As Novel Inhibitors Of Severe Acute Respiratory Syndrome Coronavirus 2 Infection, Ace2 And Ace2 - Spike Protein Interaction In Vitro, Omonike A. Olaleye, Manvir Kaur, Collins Onyenaka, Tolulope Adebusuyi Mar 2021

Discovery Of Clioquinol And Analogues As Novel Inhibitors Of Severe Acute Respiratory Syndrome Coronavirus 2 Infection, Ace2 And Ace2 - Spike Protein Interaction In Vitro, Omonike A. Olaleye, Manvir Kaur, Collins Onyenaka, Tolulope Adebusuyi

Faculty Publications

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the etiological agent for coronavirus disease 2019 (COVID-19), has resulted in an ongoing pandemic. Presently, there are no clinically approved drugs for COVID-19. Hence, there is an urgent need to accelerate the development of effective antivirals. Herein, we discovered Clioquinol (5-chloro-7-iodo-8-quinolinol (CLQ)), a Food and Drug Administration (FDA) approved drug, and two of its analogues (7-bromo-5-chloro-8-hydroxyquinoline (CLBQ14); and 5, 7-Dichloro-8-hydroxyquinoline (CLCQ)) as potent inhibitors of SARS-CoV-2 infection-induced cytopathic effect in vitro. In addition, all three compounds showed potent anti-exopeptidase activity against recombinant human angiotensin-converting enzyme 2 (rhACE2) and inhibited the binding of rhACE2 …