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The Role Of Ultrasound Cavitation In Liposome Size Reduction, William G. Pitt, Eric S. Richardson, Dixon J. Woodbury Mar 2007

The Role Of Ultrasound Cavitation In Liposome Size Reduction, William G. Pitt, Eric S. Richardson, Dixon J. Woodbury

Faculty Publications

Liposome size is a vital parameter of many quantitative biophysical studies. Sonication, or exposure to ultrasound, is used widely to manufacture artificial liposomes, yet little is known about the mechanism by which liposomes are affected by ultrasound. Cavitation, or the oscillation of small gas bubbles in a pressure-varying field, has been shown to be responsible for many biophysical effects of ultrasound on cells. Collapse cavitation is manifested in the acoustic spectrum by an f/2 subharmonic and an increase in broadband noise. In this study, we attempted to correlate the presence of cavitation with a decrease in liposome size. Lipid suspensions …

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Mathematics Library News 1, Aaron Lercher Mar 2007

Mathematics Library News 1, Aaron Lercher

Faculty Publications

No abstract provided.

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Precision In Imaging Multivariate Optical Computing, Michael N. Simcock, Michael L. Myrick Mar 2007

Precision In Imaging Multivariate Optical Computing, Michael N. Simcock, Michael L. Myrick

Faculty Publications

Multivariate optical computing (MOC) is a method of performing chemical analysis using a multilayer thin-film structure known as a multivariate optical element (MOE). Recently we have been advancing MOC for imaging problems by using an imaging MOE (IMOE) in a normal-incidence geometry and employing normalization by the 1-norm. There are several important differences between the previously described 45° and the normal-incidence imaging, one of which is the measurement precision due to photon counting. We compare this precision to 45° MOC. We also discuss how MOE models with similar values of standard errors of calibration and prediction and similar gain values …

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First Record Of A Sleeper Shark In The Western Gulf Of Mexico And Comments On Taxonomic Uncertainty Within Somniosus (Somniosus), George W. Benz, Eric R. Hoffmayer, William B. Driggers, Dan Allen, Lougan E. Bishop, David A. Brown Mar 2007

First Record Of A Sleeper Shark In The Western Gulf Of Mexico And Comments On Taxonomic Uncertainty Within Somniosus (Somniosus), George W. Benz, Eric R. Hoffmayer, William B. Driggers, Dan Allen, Lougan E. Bishop, David A. Brown

Faculty Publications

A sleeper shark, Somniosus (Somniosus) sp., is reported from Alaminos Canyon in the western Gulf of Mexico at a depth of about 2647 m based on observations made using a remotely operated vehicle. This is the first record of a sleeper shark (Somniosus, Somniosidae) from the western Gulf of Mexico and deepest record of any shark from the Gulf of Mexico. Despite claims to the contrary in the literature, no taxonomic character has been identified to date that can be used to unequivocally identify all representatives of Somniosus (Somniosus), and as a result, some species records must be considered dubious.

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Bounds And Conditions: A Kolob In Our Solar System?, David D. Allred Mar 2007

Bounds And Conditions: A Kolob In Our Solar System?, David D. Allred

Faculty Publications

In 2003, Dialogue ran adjacent essays by two scientists, David Tolman and David Allred. The two Davids had been students together at Princeton, attending the same student ward. Decades after Princeton, Tolman had left Mormonism and Allred had stayed. Their essays are a fascinating juxtaposition. In the course of his piece, David Allred ventured for a few paragraphs into a discussion of the planet Jupiter and its role as a governor and protector in our solar system—a type of Kolob. Although the other author dismissed the topic as “fanciful physics,” my own interest was piqued. I asked Dr. Allred, who …

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Trisodium Dicalcium Bismuth Hexaoxide, Irina V. Puzdrjakova, Rene B. Macquart, Mark D. Smith, Hans-Conrad Zur Loye Feb 2007

Trisodium Dicalcium Bismuth Hexaoxide, Irina V. Puzdrjakova, Rene B. Macquart, Mark D. Smith, Hans-Conrad Zur Loye

Faculty Publications

Single crystals of the title compound, Na3Ca2BiO6, were grown from a high-temperature reactive flux solution of Na2CO3. Na3Ca2BiO6 crystallizes as an ordered rock-salt structure (space group Fddd), in which the octahedral holes in the oxide array are filled by an ordered 3:2:1 arrangement of Na+, Ca2+ and Bi5+ cations. All atoms except for one O atom lie on special positions; site symmetries are as follows: Bi 222, Ca 2, Na 222 and 2, O 2.

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A Coarse Grain Model For Dna, Thomas A. Knotts Iv, Nitin Rathore, David C. Schwartz, Juan J. De Pablo Feb 2007

A Coarse Grain Model For Dna, Thomas A. Knotts Iv, Nitin Rathore, David C. Schwartz, Juan J. De Pablo

Faculty Publications

Understanding the behavior of DNA at the molecular level is of considerable fundamental and engineering importance. While adequate representations of DNA exist at the atomic and continuum level, there is a relative lack of models capable of describing the behavior of DNA at mesoscopic length scales. We present a mesoscale model of DNA that reduces the complexity of a nucleotide to three interactions sites, one each for the phosphate, sugar, and base, thereby rendering the investigation of DNA up to a few microns in length computationally tractable. The charges on these sites are considered explicitly. The model is parametrized using …

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A Coarse Grain Model For Dna, Thomas A. Knotts, Nitin Rathore, David C. Schwartz, Juan J. De Pablo Feb 2007

A Coarse Grain Model For Dna, Thomas A. Knotts, Nitin Rathore, David C. Schwartz, Juan J. De Pablo

Faculty Publications

Understanding the behavior of DNA at the molecular level is of considerable fundamental and engineering importance. While adequate representations of DNA exist at the atomic and continuum level, there is a relative lack of models capable of describing the behavior of DNA at mesoscopic length scales. We present a mesoscale model of DNA that reduces the complexity of a nucleotide to three interactions sites, one each for the phosphate, sugar, and base, thereby rendering the investigation of DNA up to a few microns in length computationally tractable. The charges on these sites are considered explicitly. The model is parametrized using …

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Poly[Diaqua(Μ4-3-Fluorophthalato-Κ4O:O:O':O'')Cadmium(Ii)], Diana Rishmawi, Katie Lewis, Mark D. Smith, Leroy Peterson Jr., Hans-Conrad Zur Loye Feb 2007

Poly[Diaqua(Μ4-3-Fluorophthalato-Κ4O:O:O':O'')Cadmium(Ii)], Diana Rishmawi, Katie Lewis, Mark D. Smith, Leroy Peterson Jr., Hans-Conrad Zur Loye

Faculty Publications

The crystal structure of the title compound, [Cd(C8H3FO4)(H2O)2]n, consists of polymeric sheets formed by the bridging of octahedrally coordinated CdII by carboxylate O atoms of the 3-fluorophthalate (3-fpt2-) ligand. The layers exhibit hydrogen bonding between each of two coordinated water molecules and two O atoms of the ligand. Adjacent sheets are connected through - interactions.

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Evaluating The Impact On Users From Implementing A Course Management System, Charles R. Graham, Meghan M. Kennedy, Gregory L. Waddoups, Richard E. West Feb 2007

Evaluating The Impact On Users From Implementing A Course Management System, Charles R. Graham, Meghan M. Kennedy, Gregory L. Waddoups, Richard E. West

Faculty Publications

Nearly all colleges and universities are using some form of e-learning system, usually an expensive course management system (CMS), to create online course offerings or to enhance regular, classroom-oriented courses. Our university has invested a large amount of resources into purchasing and supporting one of the two most popular CMS vendors, and it has become imperative to understand what the effects from using this technology have been, as well as how we can improve the integration of this and other educational technologies into different instructional contexts. This project, through a combination of surveys, call-log analysis, and interviews, was used to …

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Two Sides Of The Same Coin? The Differing Roles Of Assets And Consumer Debt In Marriage, Jeffrey P. Dew Feb 2007

Two Sides Of The Same Coin? The Differing Roles Of Assets And Consumer Debt In Marriage, Jeffrey P. Dew

Faculty Publications

This study examines whether assets and consumer debts relate to change in marital satisfaction and conflict in opposing ways or in independent ways. It also tests whether these relationships are direct or mediated. Using a nationally representative longitudinal sample, the results indicate that assets and consumer debt influence change in marital outcomes in mostly independent rather than complementary ways. Consistent with prior literature, assets work indirectly by decreasing feelings of economic pressure. Consumer debt, however, directly predicts changes in marital conflict, even after controlling for variables in the family stress model. Debts also act indirectly by decreasing depression once economic …

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Laguerre Functions On Symmetric Cones And Recursion Relations In The Real Case, Michael Aristidou, Mark Davidson, Gestur Ólafsson Feb 2007

Laguerre Functions On Symmetric Cones And Recursion Relations In The Real Case, Michael Aristidou, Mark Davidson, Gestur Ólafsson

Faculty Publications

In this article we derive differential recursion relations for the Laguerre functions on the cone Ω of positive definite real matrices. The highest weight representations of the group Sp (n, R) play a fundamental role. Each such representation acts on a Hilbert space of holomorphic functions on the tube domain Ω + i Sym (n, R). We then use the Laplace transform to carry the Lie algebra action over to L2 (Ω, d μν). The differential recursion relations result by restricting to a distinguished three-dimensional subalgebra, which is isomorphic to sl (2, R) . © 2005 Elsevier B.V. All rights …

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Further Results On Lyapunov Functions For Slowly Time-Varying Systems, Frédéric Mazenc, Michael Malisoff Feb 2007

Further Results On Lyapunov Functions For Slowly Time-Varying Systems, Frédéric Mazenc, Michael Malisoff

Faculty Publications

We provide general methods for explicitly constructing strict Lyapunov functions for fully nonlinear slowly time-varying systems. Our results apply to cases where the given dynamics and corresponding frozen dynamics are not necessarily exponentially stable. This complements our previous Lyapunov function constructions for rapidly time-varying dynamics. We also explicitly construct input-to-state stable Lyapunov functions for slowly time-varying control systems. We illustrate our findings by constructing explicit Lyapunov functions for a pendulum model, an example from identification theory, and a perturbed friction model. © Springer-Verlag London Limited 2006.

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Threshold Power Of Canonical Antennas For Inducing Sar At Compliance Limits In The 300-3000 Mhz Frequency Range, Mohammod Ali, Mark G. Douglas, Abu T.M. Sayem, Antonio Faraone, Chung-Kwang Chou Feb 2007

Threshold Power Of Canonical Antennas For Inducing Sar At Compliance Limits In The 300-3000 Mhz Frequency Range, Mohammod Ali, Mark G. Douglas, Abu T.M. Sayem, Antonio Faraone, Chung-Kwang Chou

Faculty Publications

A study of the specific absorption rate (SAR) in an exposed body induced by canonical antennas is presented, with the aim of determining an upper bound for the antenna transmit power that demonstrates that a product is inherently compliant with internationally accepted radio frequency (RF) exposure limits. Starting from the fundamental limits in antenna quality factor (Q) and the corresponding bandwidth, several antenna sizes are selected, and their SAR distributions are computed using the method of moments (MoM) and finite-difference time domain (FDTD) method in the frequency range 300-3000 MHz. The threshold powers are then determined, below which the peak …

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Parametrizations Of Inclusive Cross Sections For Pion Production In Proton-Proton Collisions. Ii. Comparison To New Data, John W. Norbury, Lawrence W. Townsend Feb 2007

Parametrizations Of Inclusive Cross Sections For Pion Production In Proton-Proton Collisions. Ii. Comparison To New Data, John W. Norbury, Lawrence W. Townsend

Faculty Publications

A set of new, precise data have recently been made available by the NA49 Collaboration for charged pion production in proton-proton and proton-Carbon reactions at 158 GeV. The current paper compares this new data to five currently available arithmetic parameterizations. Although a precise fit is not expected, two of the parameterizations do not work very well but the other three are able to provide a moderately good, but not precise fit to the proton-proton data. The best two of these three parameterizations are scaled to the proton-Carbon data and again provide a moderately good, but not precise fit.

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Modeling And Sensitivity Analysis Of Acoustic Release Of Doxorubicin From Unstabilized Pluronic P105 Using An Artificial Neural Network Model, Ghaleb A. Husseini, Nabil M. Abdel-Jabbar, Farouq S. Mjalli, William G. Pitt Feb 2007

Modeling And Sensitivity Analysis Of Acoustic Release Of Doxorubicin From Unstabilized Pluronic P105 Using An Artificial Neural Network Model, Ghaleb A. Husseini, Nabil M. Abdel-Jabbar, Farouq S. Mjalli, William G. Pitt

Faculty Publications

This paper models steady state acoustic release of Doxorubicin (Dox) from Pluronic P105micelles using Artificial Neural Networks (ANN). Previously collected release data werecompiled and used to train, validate, and test an ANN model. Sensitivity analysis was thenperformed on the following operating conditions: ultrasonic frequency, power density, Plu-ronic P105 concentration, and temperature. The model showed that drug release was mostefficient at lower frequencies. The analysis also demonstrated that release increases as thepower density increases. Sensitivity plots of ultrasound intensity revealed a drug releasethreshold of 0.015 W/cm2 and 0.38 W/cm2 at 20 and 70 kHz, respectively. The presence ofa power density threshold …

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Human–Robot Interaction: A Survey, Michael A. Goodrich, Alan C. Schultz Feb 2007

Human–Robot Interaction: A Survey, Michael A. Goodrich, Alan C. Schultz

Faculty Publications

Human–Robot Interaction (HRI) has recently received considerable attention in the academic community, in labs, in technology companies, and through the media. Because of this attention, it is desirable to present a survey of HRI to serve as a tutorial to people outside the field and to promote discussion of a unified vision of HRI within the field. The goal of this review is to present a unified treatment of HRI-related problems, to identify key themes, and discuss challenge problems that are likely to shape the field in the near future. Although the review follows a survey structure, the goal of …

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Interactive Image Repair With Assisted Structure And Texture Completion, Teryl Arnold, Bryan S. Morse Feb 2007

Interactive Image Repair With Assisted Structure And Texture Completion, Teryl Arnold, Bryan S. Morse

Faculty Publications

Removing image defects in an undetectable manner has been studied for its many useful and varied applications. In many cases the desired result may be ambiguous from the image data alone and needs to be guided by a user’s knowledge of the intended result. This paper presents a framework for interactively incorporating user guidance into the filling-in process, more effectively using user input to fill in damaged regions in an image. This framework contains five main steps: first, the scratch or defect is detected; second, the edges outside the defect are detected; third, curves are fit to the detected edges; …

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Performance Evaluation Of Vision-Based Navigation And Landing On A Rotorcraft Unmanned Aerial Vehicle, David Hubbard, Timothy W. Mclain, Bryan S. Morse, Colin Theodore, Mark Tischler Feb 2007

Performance Evaluation Of Vision-Based Navigation And Landing On A Rotorcraft Unmanned Aerial Vehicle, David Hubbard, Timothy W. Mclain, Bryan S. Morse, Colin Theodore, Mark Tischler

Faculty Publications

A Rotorcraft UAV provides an ideal experimental platform for vision-based navigation. This paper describes the flight tests of the US Army PALACE project, which implements Moravec’s pseudo-normalized correlation tracking algorithm. The tracker uses the movement of the landing site in the camera, a laser range, and the aircraft attitude from an IMU to estimate the relative motion of the UAV. The position estimate functions as a GPS equivalent to enable the rotorcraft to maneuver without the aid of GPS. With GPS data as a baseline, tests were performed in simulation and in flight that measure the accuracy of the position …

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Loop Quantum Cosmology Of K=1 Frw Models, Abhay Ashtekar, Tomasz Pawlowski, Parampreet Singh, Kevin Vandersloot Jan 2007

Loop Quantum Cosmology Of K=1 Frw Models, Abhay Ashtekar, Tomasz Pawlowski, Parampreet Singh, Kevin Vandersloot

Faculty Publications

The closed, k=1, FRW model coupled to a massless scalar field is investigated in the framework of loop quantum cosmology using analytical and numerical methods. As in the k=0 case, the scalar field can be again used as emergent time to construct the physical Hilbert space and introduce Dirac observables. The resulting framework is then used to address a major challenge of quantum cosmology: resolving the big-bang singularity while retaining agreement with general relativity at large scales. It is shown that the framework fulfills this task. In particular, for states which are semiclassical at some late time, the big bang …

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Model-Based Compartmental Analysis Indicates A Reduced Mobilization Of Hepatic Vitamin A During Inflammation In Rats, Sin Gieng, Michael Green, Joanne Green, Francisco Rosales Jan 2007

Model-Based Compartmental Analysis Indicates A Reduced Mobilization Of Hepatic Vitamin A During Inflammation In Rats, Sin Gieng, Michael Green, Joanne Green, Francisco Rosales

Faculty Publications

Vitamin A (VA) kinetics was studied in rats with marginal VA stores before, during, and after inflammation. Rats received orally [11,12-3H(N)]retinol ([3H]VA; day 0), and inflammation was induced on day 21 with lipopolysacchride (LPS) for 3 days (n = 5) or recombinant human interleukin-6 (rhIL-6) for 7 days (n = 5). Both the fraction of [3H]VA and retinol concentrations in plasma were reduced significantly by LPS or rhIL-6. Compartmental analysis using the Windows version of Simulation, Analysis, and Modeling software was applied to group mean data, and non-steady-state models were developed. After absorption, VA kinetics was described by a three-compartment …

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The Segal-Bargmann Transform For The Heat Equation Associated With Root Systems, Gestur Ólafsson, Henrik Schlichtkrull Jan 2007

The Segal-Bargmann Transform For The Heat Equation Associated With Root Systems, Gestur Ólafsson, Henrik Schlichtkrull

Faculty Publications

We study the heat equation associated to a multiplicity function on a root system, where the corresponding Laplace operator has been defined by Heckman and Opdam. In particular, we describe the image of the associated Segal-Bargmann transform as a space of holomorphic functions. In the case where the multiplicity function corresponds to a Riemannian symmetric space G / K of non-compact type, we obtain a description of the image of the space of K-invariant L2-function on G / K under the Segal-Bargmann transform associated to the heat equation on G / K, thus generalizing (and reproving) a result of B. …

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Radiation-Induced Current In Quantum Wires With Side-Coupled Nanorings, Yuriy V. Pershin Dr, Carlo Piermarocchi Jan 2007

Radiation-Induced Current In Quantum Wires With Side-Coupled Nanorings, Yuriy V. Pershin Dr, Carlo Piermarocchi

Faculty Publications

Photocurrent generation is studied in a system composed of a quantum wire with side-coupled quantum rings. The current generation results from the interplay of the particular geometry of the system and the use of circularly polarized radiation. We study the energy-momentum conservation for optical transitions involving electrons moving forward and backwards in the wire. Due to the lack of time-reversal symmetry in the radiation, the optical transitions depend on the direction of motion of the electrons, leading to a current at zero bias voltage. The photocurrent increases with the number of rings within a wide range of physical parameters. A …

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Integral And Nonnegativity Preserving Approximations Of Functions, Jiu Ding, Larry Eifler, N. H. Rhee Jan 2007

Integral And Nonnegativity Preserving Approximations Of Functions, Jiu Ding, Larry Eifler, N. H. Rhee

Faculty Publications

In this paper we consider the problem of approximating a function by continuous piecewise linear functions that preserve the integral and nonnegativity of the original function. (c) 2006 Elsevier Inc. All rights reserved.

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Catena-Poly[[Diaquadinitratozinc(Ii)]Bis(Μ-1,4-Di-3-Pyridyl-2,3-Diaza-1,3-Butadiene)], Shakoya Paulin, Pierre Kelly, Kenneth B. Williams, Andrea M. Goforth, Mark D. Smith, Leroy Peterson Jr., Hans-Conrad Zur Loye Jan 2007

Catena-Poly[[Diaquadinitratozinc(Ii)]Bis(Μ-1,4-Di-3-Pyridyl-2,3-Diaza-1,3-Butadiene)], Shakoya Paulin, Pierre Kelly, Kenneth B. Williams, Andrea M. Goforth, Mark D. Smith, Leroy Peterson Jr., Hans-Conrad Zur Loye

Faculty Publications

The polymeric title complex, [Zn(NO3)2(C24H20N8)(H2O)2]n, features distorted ZnN2O4 octahedra with each ZnII atom being located on an inversion center. Adjacent Zn ions are doubly bridged by two equivalent 1,4-di-3-pyridyl-2,3-diaza-1,3-butadiene ligands to form linear chains.

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Catena-Poly[[Bis(Α-Thenoyltrifluoroacetonato-Κ2O,O')Copper(Ii)]-Μ-1,4-Di-3-Pyridyl-2,3-Diaza-1,3-Butadiene-Κ2N:N'], William J. Perkins, Tamar Maxwell, Ken B. Williams, Andrea M. Goforth, Mark D. Smith, Leroy Peterson Jr., Hans-Conrad Zur Loye Jan 2007

Catena-Poly[[Bis(Α-Thenoyltrifluoroacetonato-Κ2O,O')Copper(Ii)]-Μ-1,4-Di-3-Pyridyl-2,3-Diaza-1,3-Butadiene-Κ2N:N'], William J. Perkins, Tamar Maxwell, Ken B. Williams, Andrea M. Goforth, Mark D. Smith, Leroy Peterson Jr., Hans-Conrad Zur Loye

Faculty Publications

The title compound, [Cu(C8H4F3O2S)2(C12H10N4)]n or [Cu(tta)2(L2)2]n (L2 = 1,4-di-3-pyridyl-2,3-diaza-1,3-butadiene and tta = -thenoyltrifluoroacetonate), consists of undulating chains containing two crystallographically distinct CuII centers that are each located on inversion centers. Each CuII center exhibits distorted octahedral coordination provided by two pyridyl N atoms from two equivalent L2 ligands and four O atoms from two equivalent tta ligands. The chains interact through weak C-FH-C contacts.

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Strain-Based Electrical Properties Of Systems Of Carbon Nanotubes Embedded In Parylene, David D. Allred, Jon Brame, Johnathan Goodsell, Stephanie Getty Jan 2007

Strain-Based Electrical Properties Of Systems Of Carbon Nanotubes Embedded In Parylene, David D. Allred, Jon Brame, Johnathan Goodsell, Stephanie Getty

Faculty Publications

We have fabricated flexible electronic devices to test the strain-based change in resistance of a network of single-walled carbon nanotubes (SWCNTs) for use in microscale, high resolution magnetometry. To do this, we first develop a simple, reliable method to obtain catalyst nanoparticles for carbon nanotube growth through indirect, thin-film evaporation. Next we fabricate a two-terminal SWCNT device on a rigid substrate. We then transfer the device, intact, to a flexible substrate for strain testing. Herein, we report progress in growth and measurement techniques.

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Neutron Interferometric Method To Provide Improved Constraints On Non-Newtonian Gravity At The Nanometer Scale, Geoffrey L. Greene, Vladimir Gudkov Jan 2007

Neutron Interferometric Method To Provide Improved Constraints On Non-Newtonian Gravity At The Nanometer Scale, Geoffrey L. Greene, Vladimir Gudkov

Faculty Publications

In recent years, an energetic experimental program has set quite stringent limits on a possible “non-1/r2” dependence on gravity at short length scales. This effort has been largely driven by the predictions of theories based on compactification of extra spatial dimensions. It is characteristic of many such theories that the strength and length scales of such anomalous gravity are not clearly determined from first principles. As a result, it is productive to extend the current limits the range and strength of such hypothetical interactions. As a heavy, neutral, and (almost) stable particle, the neutron provides an ideal probe …

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Algorithm Refinement For Fluctuating Hydrodynamics, Alejandro Garcia, S. Williams, J. B. Bell Jan 2007

Algorithm Refinement For Fluctuating Hydrodynamics, Alejandro Garcia, S. Williams, J. B. Bell

Faculty Publications

This paper introduces an adaptive mesh and algorithm refinement method for fluctuating hydrodynamics. This particle-continuum hybrid simulates the dynamics of a compressible fluid with thermal fluctuations. The particle algorithm is direct simulation Monte Carlo (DSMC), a molecular-level scheme based on the Boltzmann equation. The continuum algorithm is based on the Landau–Lifshitz Navier–Stokes (LLNS) equations, which incorporate thermal fluctuations into macroscopic hydrodynamics by using stochastic fluxes. It uses a recently developed solver for the LLNS equations based on third-order Runge–Kutta. We present numerical tests of systems in and out of equilibrium, including time-dependent systems, and demonstrate dynamic adaptive refinement by the …

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Outsourcing In Biopharmaceutical Industry: India's Value Propositions, S. Dhar, Mahesh N. Rajan Jan 2007

Outsourcing In Biopharmaceutical Industry: India's Value Propositions, S. Dhar, Mahesh N. Rajan

Faculty Publications

In this paper we discuss the rationale behind biopharmaceutical outsourcing. We then discuss the benefits, challenges, current trends and market opportunities. From January 2005, India has agreed to comply with the product patent protection in accordance with the obligation under the TRIPS Agreement of the WTO. This has created new opportunities as well as challenges for the Indian biopharmaceutical companies. We analyze the value proposition of India as a suitable destination for outsourcing in biopharmaceutical industry in this new business environment. This research will help managers to understand the benefits of biopharmaceutical outsourcing along with its challenges under the current …

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