Digital Commons Network^™

Nucleoredoxin Regulates Wnt Signaling During Pituitary Stem Cell Differentiation, Michelle L. Brinkmeier, Leonard Y M Cheung, Sean P. O'Connell, Diana K. Gutierrez, Eve C. Rhoads, Sally A. Camper, Shannon W. Davis

Faculty Publications

Nucleoredoxin (Nxn) encodes a multi-functional enzyme with oxidoreductase activity that regulates many different signaling pathways and cellular processes in a redox-dependent manner. Rare NXN mutations are reported in individuals with recessive Robinow syndrome, which involves mesomelic skeletal dysplasia, short stature, craniofacial dysmorphisms, and incompletely penetrant heart and palate defects. Here we report that Nxn is expressed in the ventral diencephalon and developing pituitary gland, and that Nxn deficient mice have pituitary dysmorphology and craniofacial abnormalities that include defects in the skull base and cleft palate. Nxn mutant mice exhibit reduced WNT signaling and reduced differentiation of pituitary stem …

Pre-Exposure Prophylaxis Uptake Among Black/African American Men Who Have Sex With Other Men In Midwestern, United States: A Systematic Review, Oluwafemi Adeagbo, Oluwaseun Abdulganiyu Badru, Prince Addo, Amber Hawkins, Monique J. Brown Ph.D., Mph, Xiaoming Li, Rima Afifi

Faculty Publications

Introduction: Black/African American men who have sex with other men (BMSM) are disproportionately affected by HIV, experience significant disparities in HIV incidence, and face significant barriers to accessing HIV treatment and care services, including pre-exposure prophylaxis (PrEP). Despite evidence of individual and structural barriers to PrEP use in the Midwest, no review has synthesized this finding to have a holistic view of PrEP uptake and barriers. This review examines patterns of, barriers to, and facilitators of PrEP uptake among BMSM in the Midwest, United States (US).

Methods: Five databases (CINAHL Plus, PUBMED, PsycINFO, SCOPUS, and Web of Science) were searched …

Teaching Archival Silences With The New Hampshire Maps Collection, Kai H. Uchida

Faculty Publications

This conference presentation was given at the Annual Spring 2025 Meeting for New England Archivists.

For the past two years, the University Archivist at Milne Special Collections and Archives at the University of New Hampshire has partnered with an instructor in the Natural Resources and Environmental Studies Department to teach about its historic map collections. This presentation will discuss the planning, execution, and lessons learned from using a historic state maps collection to educate students on the concept of "archival silence," and to advocate for the use of historical map collections to develop critical archival and data literacies.

Understanding Ionic Transport In Perovskite Lithium-Ion Conductor Li3/8Sr7/16Ta3/4Hf1/4O3: A Neutron Diffraction And Molecular Dynamics Simulation Study †, Danyi Sun, Nan Wu, Yeting Wen, Shichen Sun, Yufang He, Ke Huang, Cheng Li, Bin Ouyang, Ralph E. White, Kevin Huang

Faculty Publications

Solid-state Li-ion electrolytes (SSEs) are essential for the development of next-generation solid-state Li-metal batteries and new Li-extraction electrochemical cells. Among these, the perovskite-type SSE Li3/8Sr7/16Ta3/4Hf1/4O3 (LSTH) has garnered attention for Li-extraction applications, owing to its outstanding chemical and thermal stability and high ionic conductivity. However, its precise crystal structure and Li-ion transport mechanisms remain insufficiently understood. This study addresses these gaps by employing neutron diffraction to resolve LSTH's crystallography and machine learning force field (MLFF) based MD simulations to elucidate ionic transport mechanisms. A single-phase LSTH, synthesized via the sol–gel method, exhibits a room-temperature bulk conductivity of 0.418 mS cm−1 …

Negotiating Home In The Long Poem: Amatoritsero Ede’S Transpatiality, Mathias Iroro Orhero

Faculty Publications

In this paper, I argue that Amatoritsero Ede uses the long poem to negotiate the idea of home in an African diasporic context. As a form that carries the implications of length, time, and space, the long poem has been used by poets to interrogate the way we structure the world and to deconstruct grand narratives. The figure of the Black immigrant is one that destabilizes grand narratives of nationalism. This makes the form important in its capacity to ask important questions about nation and tradition even as it transgresses them. As a writer from the Niger Delta, a marginal …

Nanostructure Retention To 1100 °C In Soft-Templated Niobium Tungstates Using Dual-Carbon Strategy, Sean C. Wechsler, Alexander Gregg, Coby S. Collins, Santosh Kiran Balijepalli, Morgan Stefik

Faculty Publications

Mesoporous metal oxides (MMOs) have diverse applications including energy storage, catalysis, and separation membranes. Block polymer structure directing agents enable the control of morphology and pore size, however preservation of the nanostructure is often limited to a narrow range of heat treatment temperatures which constrains the tailoring of defect chemistries. High temperature treatments typically lead to collapse of the porous structure as surface area is reduced during crystal growth. Here, using a mesoporous niobium tungstate it is shown that neither in situ carbon generation nor ex situ carbon infiltration alone enable preservation of the ordered mesostructure at temperatures high enough …

Older Adults’ Health, Ethnicity, And Daily Life, Hyunsook Kang, Mihae Bae

Faculty Publications

Abstract

This study examines the relationship between ethnicity and daily functional disabilities among older adults, focusing on Activities of Daily Living (ADLs) and Instrumental Activities of Daily Living (IADLs). The analysis uses data from the 2020 National Social Life, Health, and Aging Project (NSHAP) survey, which included a sample of individuals aged 57-85 (n=3,005). Respondents provided information on their demographic background (e.g., income, gender, race, age, health, retirement, and marital status) and socioeconomic characteristics through telephone interviews.

The study hypothesized that ethnic differences would be evident in perceived difficulties with ADLs and IADLs in later life. To assess these relationships, …

Modelling The Effects Of Vegetation Distribution And Density On Hydrological Connectivity And Water Age In A River Delta, Madoche Jean Louis, Matthew Hiatt

Faculty Publications

Water transport timescales (WTTs) quantify how long it takes for water to travel through or remain in a system and are often cast as indicators of ecosystem function and health. Such timescales are known to be affected by vegetation in various environments. We quantify the impact of floodplain vegetation on WTTs within the Wax Lake Delta (WLD), a river delta system in Louisiana, USA, using a high-resolution Delft3D Flexible Mesh (DFM) model incorporating vegetation-induced flow resistance. We show that increased vegetation density leads to extended WTTs within vegetated sections of WLD while fostering flow localization and accelerating transport within distributary …

The Artificially Intelligent Rps Negotiation And Mediation Coach, John Lande

Faculty Publications

This document describes the artificially intelligent RPS Negotiation and Mediation Coach (“RPS Coach”) tool, which is an outgrowth of the Real Practice Systems (RPS) Project. It is designed to help many different users perform numerous tasks including (1) attorneys anticipating challenges, strategizing, and representing clients, (2) mediators enhancing preparation, communication, and decision-making, (3) disputing parties making better decisions, (4) ADR program administrators developing clear rules, policies, and materials, (5) educators and trainers teaching practical theory and skills, and (6) students and trainees learning practical theory and skills.

RPS theory and practice is designed to help attorneys and mediators help their …

Hd-Tacs Over The Left Frontal Aslant Tract Entrains Theta Activity Associated With Speech Motor Control, Karim Johari, Fatemeh Tabari

Faculty Publications

Transient disruption or permanent damage to the left Frontal Aslant Tract (FAT) is associated with deficits in speech production. The present study examined the application of theta (4 Hz) high-definition transcranial alternating current stimulation (HD-tACS) over the left SMA and IFG –as a part of FAT- as a potential multisite protocol to modulate neural and behavioral correlates of speech motor control. Twenty-one young adults participated in three counterbalanced sessions in which they received in-phase, anti-phase, and sham theta HD-tACS. In each session, 4 Hz stimulation was applied over the left IFG and SMA, and subsequently EEG data was recorded while …

The Application Of Non-Invasive Neuromodulation In Stuttering: Current Status And Future Directions, Mehdi Bakhtiar, Karim Johari

Faculty Publications

Non-invasive neuromodulation methods such as transcranial Direct Current Stimulation (tDCS) and Transcranial Magnetic Stimulation (TMS), have been extensively utilized to enhance treatment efficacy for various neurogenic communicative disorders. Recently, these methods have gained attention for their potential to reveal more about the underlying nature of stuttering and serve as adjunct therapeutic approaches for stuttering intervention. In this review, we present existing research and discuss critical factors that might influence the efficacy of these interventions, such as location, polarity, intensity, and duration of stimulation, as well as the impact of combined behavioral training. Additionally, we explore implications for future studies, including …

Modulators Of Energy Expenditure Accuracy In Adults With Overweight Or Obesity: E-Mechanic Secondary Analyses, Rachel Matthews, Christoph Höchsmann, Melissa L. Erickson, James L. Dorling, Guillaume Spielmann, Neil M. Johannsen, Timothy S. Church, Corby K. Martin

Faculty Publications

Purpose American College of Sports Medicine (ACSM) metabolic equations are used to estimate energy expenditure (EE) of physical activity and prescribe aerobic exercise to meet EE requirements. Limited evidence supports their accuracy in sedentary adults with overweight or obesity during controlled exercise interventions. The purpose of this study was to compare EE estimated by the ACSM walking equation versus EE measured by indirect calorimetry during a 24-wk aerobic exercise intervention, and identify potential modulators for their accuracy. Methods Data from the exercising groups (8 or 20 kcal·kg body weight-1·wk-1) of the E-MECHANIC study were utilized in this ancillary analysis (N …

Effect Of Training Status On Muscle Excitation And Neuromuscular Fatigue With Resistance Exercise With And Without Blood Flow Restriction In Young Men, Brett H. Davis, Guillaume Spielmann, Neil M. Johannsen, Victoria Fairchild, Timothy D. Allerton, Brian A. Irving

Faculty Publications

This study compared muscle (vastus lateralis) excitation, muscle activation, and neuromuscular fatigue in response to low-load resistance exercise with blood flow restriction (LLBFR), medium-load resistance exercise with blood flow restriction (MLBFR), and high-load resistance exercise (HLRE) in resistance-trained (RT; n = 15) and untrained (UT; n = 14) college-aged males. Muscle excitation and activation were measured using surface electromyography (sEMG) and defined as the maximal root mean square amplitudes (RMS AMP) and the integrated area under the sEMG curve (iEMG) per repetition. Neuromuscular fatigue was defined as the reduction in peak torque measured during the postexercise knee extensor maximal isometric …

Prompt Gamma-Ray Burst Recognition Through Waterfalls And Deep Learning, Michela Negro, Nicoló Cibrario, Eric Burns, Joshua Wood, Adam Goldstein, Tito Dal Canton

Faculty Publications

Gamma-ray bursts (GRBs) are one of the most energetic phenomena in the cosmos, whose study can probe physics extremes beyond the reach of laboratories on Earth. Our quest to unravel the origin of these events and understand their underlying physics is far from complete. Central to this pursuit is the rapid classification of GRBs to guide follow-up observations and analysis across the electromagnetic spectrum and beyond. Here, we introduce a compelling approach that can set a milestone toward a new and robust GRB prompt classification method. Leveraging self-supervised deep learning, we pioneer a previously unexplored data product to approach this …

Grb 221009a: The B.O.A.T. Burst That Shines In Gamma Rays, M. Axelsson, M. Ajello, M. Arimoto, L. Baldini, J. Ballet, M. G. Baring, C. Bartolini, D. Bastieri, J. Becerra Gonzalez, R. Bellazzini, B. Berenji, E. Bissaldi, R. D. Blandford, R. Bonino, P. Bruel, S. Buson, R. A. Cameron, R. Caputo, P. A. Caraveo, E. Cavazzuti, C. C. Cheung, G. Chiaro, N. Cibrario, S. Ciprini, G. Cozzolongo, P. Cristarella Orestano, M. Crnogorcevic, A. Cuoco, S. Cutini, F. D’Ammando, S. De Gaetano, N. Di Lalla, A. Dinesh

Faculty Publications

We present a complete analysis of Fermi Large Area Telescope (LAT) data of GRB 221009A, the brightest gamma-ray burst (GRB) ever detected. The burst emission above 30 MeV detected by the LAT preceded, by 1 s, the low-energy (< 10 MeV) pulse that triggered the Fermi Gamma-Ray Burst Monitor (GBM), as has been observed in other GRBs. The prompt phase of GRB 221009A lasted a few hundred seconds. It was so bright that we identify a bad time interval of 64 s caused by the extremely high flux of hard X-rays and soft gamma rays, during which the event reconstruction efficiency was poor and the dead time fraction quite high. The late-time emission decayed as a power law, but the extrapolation of the late-time emission during the first 450 s suggests that the afterglow started during the prompt emission. We also found that high-energy events observed by the LAT are incompatible with synchrotron origin, and, during the prompt emission, are more likely related to an extra component identified as synchrotron self-Compton (SSC). A remarkable 400 GeV photon, detected by the LAT 33 ks after the GBM trigger and directionally consistent with the location of GRB 221009A, is hard to explain as a product of SSC or TeV electromagnetic cascades, and the process responsible for its origin is uncertain. Because of its proximity and energetic nature, GRB 221009A is an extremely rare event.

Structural And Magnetic Properties Of Cotemo O6, Yu Li, Jared Coles, Xin Gui, Hyowon Park, Yan Wu, Xinglong Chen, Jing Han Chen, Xiaoping Wang, Huibo Cao, Shane Stadler, Omar Chmaissem, David P. Young, Stephan Rosenkranz, John F. Ditusa

Faculty Publications

We have conducted a comprehensive investigation into the magnetic properties of the chiral multiferroic material CoTeMoO6. In contrast with the previous claim of canted antiferromagnetic order with ferromagnetic components [Y. Doi, J. Solid State Chem. 182, 3232 (2009)10.1016/j.jssc.2009.09.008], our investigation reveals an antiferromagnetic ground state with compensated moments, providing an interesting platform for exploring exotic material properties. Through careful measurements of magnetization under a series of applied fields, we demonstrate that there exist two sequential field-induced magnetic transitions in CoTeMoO6, with one occurring at Hc1=460 Oe along the a axis, and the other at Hc2=1.16 T with the field along …

A Wounded Healer: Childhood Trauma’S Effects On Pastoral Ministry, David Sedlacek, René Drumm

Faculty Publications

No abstract provided.

A Wounded Healer: Childhood Trauma’S Eeffects On Pastoral Ministry, David Sedlacek, René Drumm

Faculty Publications

No abstract provided.

The Contemporary Distribution Of Scincine Lizards Does Not Reflect Their Biogeographic Origin, Aniruddha Datta-Roy, Matthew C. Brandley, Christopher C. Austin, Aaron M. Bauer, David James Harris, Salvador Carranza, Kanishka D.B. Ukuwela, Anslem De Silva, Krystal A. Tolley, K. Praveen Karanth, Maitreya Sil

Faculty Publications

Aim: We assess the systematic relationships and historical biogeographic patterns in the subfamily Scincinae, a group of lizards that primarily inhabits the Afro-Madagascan and Saharo-Arabian regions with isolated lineages in Europe, North America, East Asia, India and Sri Lanka. The contemporary distribution of these lineages on the historical Laurasian and Gondwanan landmasses make scincines an ideal system to study the roles of vicariance and dispersal on a geologic scale of tens of millions of years. Location: Global. Taxon: Subfamily Scincinae (Family Scincidae). Methods: We conducted biogeographic analyses on a reconstructed, time-calibrated species tree of scincine genera, including members of the …

Time-Series Data-Driven Pm2.5 Forecasting: From Theoretical Framework To Empirical Analysis, Chunlai Wu, Ruiyang Wang, Siyu Lu, Jiawei Tian, Lirong Yin, Lei Wang, Wenfeng Zheng

Faculty Publications

PM2.5 in air pollution poses a significant threat to public health and the ecological environment. There is an urgent need to develop accurate PM2.5 prediction models to support decision-making and reduce risks. This review comprehensively explores the progress of PM2.5 concentration prediction, covering bibliometric trends, time series data characteristics, deep learning applications, and future development directions. This article obtained data on 2327 journal articles published from 2014 to 2024 from the WOS database. Bibliometric analysis shows that research output is growing rapidly, with China and the United States playing a leading role, and recent research is increasingly focusing on data-driven …

Modeling Machine Learning: A Cognitive Economic Approach, Andrew Caplin, Daniel Martin, Philip Marx

Faculty Publications

We investigate whether the predictions of modern machine learning algorithms are consistent with economic models of human cognition. To test these models we run an experiment in which we vary the loss function used in training a leading deep learning convolutional neural network to predict pneumonia from chest X-rays. The first cognitive economic model we test, capacity-constrained learning, corresponds with an intuitive notion of machine learning: that an algorithm chooses among a feasible set of learning strategies in order to minimize the loss function used in training. Our experiment shows systematic deviations from the testable implications of this model. Instead, …

Religious Nationalism: Narendra Modi’S 2019 Election Victory Speech, Nihar Sreepada

Faculty Publications

The ideology of nationalism is permeating and ascending across societies, eventually manifesting materially in several nations across the world. In this essay, I analyze the religious manifestation of nationalism within the context of India’s Hindu nationalism. I argue that Modi, in his 2019 election victory speech, constructs a grand narrative of Hindu nationalistic unification by positioning himself as a Hindu sanyasi (ascetic) and by alluding to Hindu mythologies. First, I present the historical context of India’s Hindu nationalism (Hindutva). Second, I explicate the formation of an ideological discourse through Kenneth Burke’s focus on identification and the constitutive rhetoric of calling …

Church Leaders’ Health Behaviors And Program Implementation In The Faith, Activity, And Nutrition Program In The United States, Kelsey R. Day, Sara Wilcox Phd, Lindsay Decker, John Bernhart Ph.D., Mph, Ches, Meghan Baruth, Andrew T. Kaczynski Ph.D., Christine A. Pellegrini Ph.D.

Faculty Publications

Objectives: Church leaders are important to the success of faith-based health promotion interventions through the role modeling of health behaviors. However, clergy may be at a higher risk of chronic disease than their congregants and their health is understudied. This study examined church leaders’ health-related behaviors, differences in health behaviors by socio-demographic characteristics, and associations between health behaviors and church-level implementation of an ecological intervention. Methods: Pastors (n = 93) and church coordinators (n = 92) reported body mass index (BMI), self-rated health, fruit and vegetable consumption (F&V), and physical activity (PA) at baseline and 12 months post-training in the …

Increasing A-Type Co32− Substitution Decreases The Modulus Of Apatite Nanocrystals, Stephanie Wong, Abigail Eaton, Christina Krywka, Arun Nair, Christophe Drouet, Alix Deymier

Faculty Publications

Biological apatite mineral is highly substituted with carbonate (CO₃²⁻). CO₃²⁻ can exchange for either phosphate, known as B-type, or hydroxyl groups, known as A-type. Although the former has been extensively studied, A-type CO₃²⁻ substituted apatites are poorly understood. Therefore, A-type CO₃²⁻ apatites with biologically relevant levels of CO32− (1.7–5.8 wt%) were prepared and characterized. The addition of A-type CO₃²⁻ into the apatite structure caused the predicted expansion of the a-axis and contraction of the c-axis in the unit cell. This was accompanied by a significant modification in the atomic …

Modifiable And Non-Modifiable Risk Factors For Dementia Among Non-Hispanic White And Black Populations Aged 50-64 In The United States, 2006-2016, Jingkai Wei, Matthew C. Lohman Ph.D., Monique J. Brown, James W. Hardin, Chih-Hsiang Yang, Anwar T. Nerchant, Daniela B. Friedman

Faculty Publications

Background and Objectives

Research Design and Methods

Geographic Disparities In Unpaid Caregiving, Emma Kathryn Boswell, Monique J. Brown Ph.D., Mph, Lorie Donelle Phd, Rn, Fcan, Nicholas Yell, Taryn Farrell, Peiyin Hung Ph.D., Elizabeth Crouch Ph.D.

Faculty Publications

Purpose: An updated, nationally representative examination of rural–urban differences in the experiences, health, and well-being of caregivers is needed; previous research on this topic uses older data or has limited generalizability. This study examines rural–urban differences in the characteristics, experiences, and health of caregivers. Methods: The 2021–2022 Behavioral Risk Factor Surveillance System (n = 44,274 unpaid caregivers) was used, with rurality defined according to the 2013 National Center for Health Statistics (NCHS) Urban-Rural Classification Scheme. Chi-square tests compared rural–urban differences in these caregivers’ characteristics, including demographic factors, caregiving intensity (e.g., weekly hours spent caregiving, reason for caregiving, past-month ADL/IADL assistance), …

Race, The Academy, And The Constitution Of The War On Drugs, Bennett Capers, Jeffrey Bellin

Faculty Publications

The war on drugs is widely viewed as a policy failure. Despite massive government intrusions on personal liberty, drug addiction, overdoses, and drug-related violence have only increased since the war was declared in 1971. David Pozen’s new book, The Constitution of the War on Drugs, reveals a constitutional failure as well. Pozen chronicles a host of constitutional arguments that American litigants deployed to protect a “right” to use drugs with surprising, if fleeting, success. Pozen asks what might have been, exploring why the courts backtracked and effectively removed the Constitution as a meaningful obstacle to drug prohibitions.

This Review …

Rural–Urban Differences In Substance Use During Pregnancy, Emma Kathryn Boswell, Olivia M. Hinds, Cassie Odahowski Phd, Mph, Elizabeth L. Crouch, Peiyin Hung Ph.D, Christina M. Andrews Ph.D.

Faculty Publications

Purpose: Drug overdoses are now a leading cause of pregnancy-related deaths in the United States. Despite evidence of rural–urban disparities in substance use, there has not yet been a nationally representative examination of rural–urban differences in perinatal substance use. This study provides a comprehensive examination of rural–urban disparities in perinatal substance use. Methods: This study uses cross-sectional data to examine 3499 pregnant women from the 2015–2019 National Survey on Drug Use and Health (NSDUH). Rural (nonmetro)–urban (metro) differences in past-month tobacco use, alcohol use, binge drinking, illicit drug use, and marijuana use were examined using Rao–Scott chi-square tests and multivariable …

Trends In Scholarly Communication, Eleta Exline

Faculty Publications

Slides from a presentation on scholarly communication developments to the UNH Retired Faculty Association.

Effects Of Carbon Substitution On Magnetic Properties And Magnetocaloric Effects In Mn65-Xga17c18+X Compounds, A. Oli, I. Dubenko, A. Granovsky, R. Razhabov, M. Hill, Yu Koshkid'ko, S. Stadler, N. Ali, S. Talapatra

Faculty Publications

We present an investigation involving the tuning of the magnetic, magnetocaloric, and room-temperature structural properties of Mn65-xGa17C18+x (0 ≤ x ≤ 4) compounds prepared using a high-energy ball milling (HEBM) technique. This study indicates that the crystal structure of all the compounds can be described as an anti-perovskite cubic structure with the Pm-3m space group and the crystal cell volume decreases with increasing carbon concentration. The system shows a first-order structural phase transition at a temperature T = TM between two cubic phases having different magnetic structures. The phases are characterized by antiferromagnetic (AFM) and ferromagnetic (FM) -like behavior at …